WO2024255152A1 - 可驱动的释药取样一体胶囊 - Google Patents

可驱动的释药取样一体胶囊 Download PDF

Info

Publication number
WO2024255152A1
WO2024255152A1 PCT/CN2023/136582 CN2023136582W WO2024255152A1 WO 2024255152 A1 WO2024255152 A1 WO 2024255152A1 CN 2023136582 W CN2023136582 W CN 2023136582W WO 2024255152 A1 WO2024255152 A1 WO 2024255152A1
Authority
WO
WIPO (PCT)
Prior art keywords
sleeve
shell
drug
side wall
external thread
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2023/136582
Other languages
English (en)
French (fr)
Inventor
徐海峰
刘祥超
刘源
刘楚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Publication of WO2024255152A1 publication Critical patent/WO2024255152A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present application relates to the technical field of medical devices, and in particular to a drivable integrated drug-releasing and sampling capsule.
  • capsule endoscopes For example, many hospitals have begun to use capsule endoscopes. Patients swallow a capsule-sized endoscope, which follows the circulation of the stomach and intestines to complete a complete picture of the entire length of the stomach and intestines, and then the doctor examines the contents of the picture. This capsule endoscope can complete the examination without the patient's perception, greatly reducing the patient's pain. However, the existing capsule endoscope can only be used for detection, not for treatment, and cannot achieve precise positioning.
  • the embodiments of the present application provide a driveable integrated drug release and sampling capsule, which can achieve targeted release of drugs at precise locations and precise dosages in the human intestine and almost non-invasive tissue sampling.
  • an embodiment of the present application provides a drivable integrated drug-releasing and sampling capsule, comprising a shell; a first external thread is provided on the outer wall of the shell, and an internal thread is provided on the inner wall; the first external thread and the internal thread have the same rotation direction; a first drug outlet is provided at the tail of the shell, and a sampling needle is provided at the head; a sleeve and a plunger are provided in the shell; the sleeve is a cylinder with an opening at one end; the sleeve is slidably connected to the shell; the plunger comprises a threaded section and an optical axis section; a second external thread matching the internal thread is provided on the threaded section, the optical axis section extends into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of
  • the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the shell; the plurality of first radial holes are evenly distributed along the circumference of the shell; the second drug outlet is a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the bottom of the shell, the positions of the second radial holes correspond one-to-one to those of the first radial holes.
  • a convex ridge extending in the axial direction is provided on the outer side wall of the sleeve, and a sliding groove matched with the convex ridge is provided on the inner side wall of the shell.
  • micro-thorns are provided on the tail end surface of the shell.
  • annular groove is provided on the inner side wall of the shell, and a boss matched with the annular groove is provided on the head of the sleeve, and the boss can slide along the axial direction of the annular groove.
  • the embodiment of the present application also provides a second drivable integrated drug-releasing and sampling capsule, comprising an outer shell; a first external thread is provided on the outer wall of the outer shell, and an internal thread is provided on the inner wall; the first external thread and the internal thread have the same rotation direction; a first drug outlet is provided at the tail of the outer shell; a sleeve and a plunger are provided in the outer shell; the sleeve is a cylinder with an opening at one end; the sleeve is slidably connected to the outer shell; the plunger comprises a threaded section and an optical axis section; the threaded section is provided with a second external thread that matches the internal thread, and the optical axis section extends into the sleeve
  • the outer shell has a bottom surface and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve
  • the first drug outlet is a plurality of first radial holes arranged at the bottom of the side wall of the shell; the plurality of first radial holes are evenly distributed along the circumference of the shell; the second drug outlet is a plurality of second radial holes arranged on the side wall of the sleeve; when the sleeve runs to the bottom of the shell, the positions of the second radial holes correspond one-to-one to those of the first radial holes.
  • a convex ridge extending in the axial direction is provided on the outer side wall of the sleeve, and a sliding groove matched with the convex ridge is provided on the inner side wall of the shell.
  • micro-thorns are provided on the tail end surface of the shell.
  • annular groove is provided on the inner side wall of the shell, and a boss matched with the annular groove is provided on the head of the sleeve, and the boss can slide along the axial direction of the annular groove.
  • the drivable integrated drug-releasing and sampling capsule of the embodiment of the present application is aimed at the affected part of the gastrointestinal tract.
  • targeted and point-fixed drug release can be achieved, thereby accurately controlling the amount of drug used, reducing side effects, and ensuring that the affected part receives adequate drug treatment.
  • the drivable integrated drug-releasing and sampling capsule of the embodiment of the present application has both drug-releasing and sampling functions, and can complete both drug-releasing and tissue sampling functions by being inserted once.
  • the embodiment of the present application can drive the integrated drug-releasing and sampling capsule to perform tissue sampling, which helps doctors better understand the condition of the affected area and can save patients from surgery, catheterization, guidewire insertion, etc., thereby alleviating patients' pain.
  • FIG1 is a schematic structural diagram of a drivable integrated drug-releasing and sampling capsule according to an embodiment of the present application
  • FIG2 is a schematic diagram of the structure of a drivable integrated drug-releasing and sampling capsule according to another embodiment of the present application.
  • first and second are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as “first” or “second” may explicitly or implicitly include one or more of the features. In the description of this application, unless otherwise specified, “plurality” means two or more.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • an embodiment of the present application provides a drivable integrated drug release and sampling capsule. Its working environment is an intestinal environment.
  • the drivable integrated drug release and sampling capsule specifically includes a shell 1 , a sleeve 2 , a plunger 3 and a sampling needle 4 .
  • the shell 1 is a hollow cylindrical structure with a closed head and a bottom cover at the tail. Specifically, a first external thread 11 is provided on the outer wall of the shell 1, and an internal thread 12 is provided on the inner wall; the first external thread 11 and the internal thread 12 have the same rotation direction; the first external thread 11 covers the entire outer wall of the shell 1, and the internal thread 12 has only one section and is arranged near the head of the shell 1. Both the first external thread 11 and the internal thread 12 are magnetic.
  • the body of the shell 1 can be processed by plastic, and then the nesting with the first external thread 11 and the internal thread 12 processed by magnetic material can be nested on the outside and inside of the plastic, so that the first external thread 11 and the internal thread 12 are both magnetic.
  • the shell 1 can also be directly processed by magnetic material to ensure that the first external thread 11 and the internal thread 12 are both magnetic.
  • the specific processing method is selected according to the actual situation and is not limited here.
  • the tail end surface of the shell 1 is provided with a micro-thorn 13, and the top cover is provided with a through hole, and a sampling needle 4 is provided at the through hole, and the inner cavity of the sampling needle 4 is connected with the inner cavity of the shell 1.
  • the sampling needle 4 is integrally formed with the shell 1.
  • the bottom of the side wall is provided with a first drug outlet.
  • the first drug outlet is a plurality of first radial holes 14 uniformly distributed along the circumference of the shell 1.
  • a sleeve 2 and a plunger 3 are provided in the housing 1.
  • the sleeve 2 is a cylinder with an opening at one end.
  • the sleeve 2 is slidably connected to the housing 1.
  • a convex ridge extending in the axial direction is provided on the outer wall of the sleeve 2
  • a sliding groove 15 matched with the convex ridge is provided on the inner wall of the housing 1.
  • An annular groove 16 is also provided on the inner wall of the housing 1, and a boss 21 matched with the annular groove 16 is provided on the head of the sleeve 2, and the boss 21 can slide along the axial direction of the annular groove 16. In this way, the guiding property can be enhanced.
  • the annular groove 16 here can also be a tool-retracting groove.
  • the plunger 3 includes a threaded section 31 and an optical axis section 32.
  • the threaded section 31 is provided with a second external thread 33 that is compatible with the internal thread 12, and the second external thread 33 is also magnetic.
  • the optical axis section 32 extends into the interior of the sleeve 2 and can slide along the axial direction of the sleeve 2, and the bottom surface of the optical axis section 32, the bottom surface of the sleeve 2 and the inner side wall of the sleeve 2 form a drug storage chamber 5.
  • the drug storage chamber 5 functions as a drug warehouse, and liquid drugs are stored therein.
  • a second drug outlet is provided on the side wall of the drug storage chamber 5.
  • the second drug outlet is a plurality of second radial holes 51. The number of the second radial holes 51 is equal to the number of the first radial holes 14.
  • the plunger 3 can push the sleeve 2 to move axially along the shell 1.
  • the second radial hole 51 and the first radial hole 14 are staggered, and the second radial hole 51 is blocked by the side wall of the shell 1, and the medicine in the medicine storage cavity 55 cannot flow out.
  • the sleeve 2 moves to the bottom of the shell 1, the positions of the second radial hole 51 and the first radial hole 14 correspond one by one.
  • the medicine storage cavity 5 is connected to the outside, and the plunger 3 pushes the liquid medicine in the medicine storage cavity 5 to flow out. It should be noted that the capsule is closed after installation.
  • Example 1 The working principle of Example 1 of the present application is as follows:
  • the drug sampling integrated capsule that can be driven to release in the embodiment of the present application is controlled by an external magnetic drive system, and the external magnetic drive system can apply a positive and reverse rotating magnetic field.
  • the external magnetic drive system is a prior art and will not be described in detail here.
  • the external magnetic control system applies a positive rotating magnetic field, and the capsule rotates as a whole, and screws forward under the action of the first external thread 11 on the surface of the shell 1.
  • the forward trend of the plunger 3 in the shell 1 is also close to the sampling needle 4, so the medicine will not be squeezed at this time.
  • tissue sampling or drug release can be selected. It should be noted that the tissue sampling and drug release operations can be completed in sequence, and the two can be completed in no particular order, or only the tissue sampling or drug release operation can be completed.
  • the external magnetic drive system is controlled to adjust the direction of rotation of the magnetic field so that the sampling needle 4 faces the sampling area, and then the capsule is rotated forward until the sampling needle 4 penetrates the tissue, and then the magnetic field is rotated in the opposite direction, and the capsule rotates in the opposite direction so that the sampling needle 4 withdraws, and part of the tissue will remain in the sampling needle 4, thereby completing the sampling operation.
  • the magnetic field needs to rotate in the opposite direction.
  • the capsule retreats to the nearby tissue wall, and the micro-thorns 13 at the bottom of the capsule penetrate into the tissue, fixing the shell 1.
  • the magnetic field continues to rotate in the opposite direction, and the plunger 3 inside the capsule screws in toward the bottom. Due to the incompressibility of the liquid in the drug storage chamber 5, the sleeve 2 will be pushed out first, and the second radial hole 51 on the sleeve 2 will be aligned with the first radial hole 14 on the shell 1.
  • the plunger 3 continues to screw in toward the bottom, slowly pushing the liquid medicine inside the drug storage chamber 55 out of the capsule, completing the drug release.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the embodiment of the present application also provides a drivable integrated drug-releasing and sampling capsule.
  • Its working environment is an intestinal environment.
  • the sampling forceps 6 are used instead of the sampling needle 4 in Example 2.
  • the head of the plunger 3 is provided with a driving rod 7, and the head of the housing 1 is provided with a limiting sleeve 8.
  • the driving rod 7 extends out of the limiting sleeve 8 at one end away from the plunger 3 and is connected to the sampling forceps 6.
  • the plunger 3 moves axially, it drives the driving rod 7, and then drives the sampling forceps 6 to close to complete the sampling.
  • the limiting sleeve 8 is integrally formed with the housing 1.
  • Example 2 The working principle of Example 2 of the present application is as follows:
  • the drug sampling integrated capsule that can be driven and released in the embodiment of the present application is also controlled by an external magnetic drive system. Its driving principle and drug release principle are the same as those in embodiment 1, and will not be described in detail here.
  • the external magnetic drive system is controlled to adjust the rotation direction of the magnetic field so that the sampling clamp 6 is opened and fully embedded in the tissue.
  • the sampling clamp 6 contains tissue blocks inside and is wrapped by tissue outside.
  • the magnetic field is rotated in the opposite direction.
  • the traction force transmitted to the sampling clamp 6 by the plunger 3 will cause the sampling clamp 6 to close first.
  • the capsule is driven in the opposite direction, and the sampling clamp 6 will be separated from the tissue, completing the sampling process.

Landscapes

  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

医疗器械技术领域的一种可驱动的释药取样一体胶囊，可以实现人体肠道内精准位置、精确用量的药物靶向释放以及几乎无创的组织取样。该胶囊包括外壳（1）；外壳（1）上设有旋向相同的第一外螺纹（11）和内螺纹（12）；其尾部设有第一出药口，头部设有取样针（4）；外壳（1）内设有套筒（2）和柱塞（3）；套筒（2）为一端具有开口的圆筒，柱塞（3）包括螺纹段（31）和光轴段（32）；螺纹段（31）上设有与内螺纹（12）相适配的第二外螺纹（33），光轴段（32）伸入套筒（2）内部并能够在套筒（2）内沿轴向滑动，且光轴段（32）的底面、套筒（2）的底面和套筒（2）的内侧壁围成储药腔（5）；储药腔（5）的侧壁上设有第二出药口；柱塞（3）能够推动套筒（2）沿外壳（1）的轴向运动；当套筒（2）运行至外壳（1）的底部时，第一出药口和第二出药口连通；第一外螺纹（11）和第二外螺纹（33）均具有磁性。

Description

可驱动的释药取样一体胶囊 技术领域
本申请涉及医疗器械技术领域，尤其涉及一种可驱动的释药取样一体胶囊。
 背景技术
传统的治疗手段，比如手术和药物治疗，在长期的使用中都逐渐暴露了一些缺点。按现代医疗技术的观点，这些都属于比较粗糙的治疗方式。比如手术必须在皮肤上打开一个创口，也会伤及沿途的组织。传统用药也是使药物进入血液循环作用于全身，因此都属于效率比较低的治疗方法。
另外，传统的通过吞服药丸或者胶囊的方式摄入的药物大部分被肠胃、肝脏处理掉了，只有剩余的一小部分进入血液循环，而这一小部分最终只有更少的部分到达患处。因此医生给病人安排的药物量都远高于病人最终起效的药量。多余的药物量不可避免的给病人带去各种副作用，尤其是一些副作用较大的药物。
随着技术的发展，人们开始追求更加精细的治疗手段。比如使创口尽量小的微创手术，甚至是无创手术；又比如精确作用的靶向药物，靶向投递等。胶囊正是在这样的需求下诞生的。得益于其整体尺寸足够小，可以做到靶向药物投递。给胶囊装配上一些操控机构，比如微型相机、取样针、微型取样抓等，则可以完成一些精细操作。
比如在很多医院中已经开始使用的胶囊内窥镜，病人吞下一枚胶囊大小的内窥镜，胶囊内窥镜随肠胃的循环完成肠胃全长的一个完整拍摄，随后由医生对拍摄内容进行检查。这种胶囊内窥镜可以在病人几乎无感知的情况下完成检查，极大地减轻了病人的痛苦。但是现有的胶囊内窥镜的只能用于检测，无法完成治疗，而且不能实现精确定位。
 技术问题
本申请的实施例提供一种可驱动的释药取样一体胶囊，可以实现人体肠道内精准位置、精确用量的药物靶向释放以及几乎无创的组织取样。
 技术解决方案
为达到上述目的，一方面，本申请的实施例提供了一种可驱动的释药取样一体胶囊，包括外壳；所述外壳的外侧壁上设有第一外螺纹，内侧壁上设有内螺纹；所述第一外螺纹和所述内螺纹的旋向相同；所述外壳的尾部设有第一出药口，头部设有取样针；所述外壳内设有套筒和柱塞；所述套筒为一端具有开口的圆筒；所述套筒与所述外壳滑动连接；所述柱塞包括螺纹段和光轴段；所述螺纹段上设有与所述内螺纹相适配的第二外螺纹，所述光轴段伸入套筒内部并能够沿套筒的轴向滑动，且所述光轴段的底面、所述套筒的底面和所述套筒的内侧壁围成储药腔；所述储药腔的侧壁上设有第二出药口；所述柱塞能够推动所述套筒沿外壳的轴向运动；当所述套筒运行至所述外壳的底部时，所述第一出药口和所述第二出药口连通；所述第一外螺纹和所述第二外螺纹均具有磁性。
进一步地，所述第一出药口为设置在所述外壳的侧壁底部的多个第一径向孔；多个所述第一径向孔沿所述外壳的周向均布；所述第二出药口为设置在所述套筒的侧壁上的多个第二径向孔；当所述套筒运行至所述外壳的底部时，所述第二径向孔与所述第一径向孔的位置一一对应。
进一步地，所述套筒的外侧壁上设有沿轴向延伸的凸棱，所述外壳的内侧壁上设有与所述凸棱相适配的滑槽。
进一步地，所述外壳的尾部端面上设有微刺。
进一步地，所述外壳的内侧壁上还设有环槽，所述套筒的头部设有与所述环槽相适配的凸台，所述凸台能够沿所述环槽的轴向滑动。
另一方面，本申请的实施例还提供了第二种可驱动的释药取样一体胶囊，包括外壳；所述外壳的外侧壁上设有第一外螺纹，内侧壁上设有内螺纹；所述第一外螺纹和所述内螺纹的旋向相同；所述外壳的尾部设有第一出药口；所述外壳内设有套筒和柱塞；所述套筒为一端具有开口的圆筒；所述套筒与所述外壳滑动连接；所述柱塞包括螺纹段和光轴段；所述螺纹段上设有与所述内螺纹相适配的第二外螺纹，所述光轴段伸入套筒内部并能够沿套筒的轴向滑动，且所述光轴段的底面、所述套筒的底面和所述套筒的内侧壁围成储药腔；所述储药腔的侧壁上设有第二出药口；所述柱塞能够推动所述套筒沿外壳的轴向运动；当所述套筒运行至所述外壳的底部时，所述第一出药口和所述第二出药口连通；所述柱塞的头部设有驱动杆；外壳的头部设有限位套；所述驱动杆远离所述柱塞的一端伸出所述限位套后连接取样钳；所述第一外螺纹和第二外螺纹均具有磁性。
进一步地，所述第一出药口为设置在所述外壳的侧壁底部的多个第一径向孔；多个所述第一径向孔沿所述外壳的周向均布；所述第二出药口为设置在所述套筒的侧壁上的多个第二径向孔；当所述套筒运行至所述外壳的底部时，所述第二径向孔与所述第一径向孔的位置一一对应。
进一步地，所述套筒的外侧壁上设有沿轴向延伸的凸棱，所述外壳的内侧壁上设有与所述凸棱相适配的滑槽。
进一步地，所述外壳的尾部端面上设有微刺。
进一步地，所述外壳的内侧壁上还设有环槽，所述套筒的头部设有与所述环槽相适配的凸台，所述凸台能够沿所述环槽的轴向滑动。
 有益效果
本申请相比现有技术具有以下有益效果：
1、本申请实施例可驱动的释药取样一体胶囊针对肠胃处的患处，通过操控外部磁驱系统，可以实现靶向定点释药，从而精确控制药物的使用量、减小副作用，同时保证患处得到充分的药物治疗。
2、本申请实施例可驱动的释药取样一体胶囊兼具释药和采样功能，一次放入即可完成释药和组织取样两种功能。
3、本申请实施例可驱动的释药取样一体胶囊进行组织取样，帮助医生更好的了解患处的病情，并可以使病人免于手术开刀，插导管导丝等，减轻病人的痛苦。
 附图说明
为了更清楚地说明本申请实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为本申请一个实施例可驱动的释药取样一体胶囊的结构示意图；
图2为本申请另一个实施例可驱动的释药取样一体胶囊的结构示意图。
 本发明的实施方式
下面将结合本申请实施例中的附图，对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本申请一部分实施例，而不是全部的实施例。基于本申请中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本申请保护的范围。
在本申请的描述中，需要理解的是，术语“中心”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本申请和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本申请的限制。
在本申请的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；对于本领域的普通技术人员而言，可以具体情况理解上述术语在本申请中的具体含义。
术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本申请的描述中，除非另有说明，“多个”的含义是两个或两个以上。
实施例1：
参照图1，本申请的实施例提供了一种可驱动的释药取样一体胶囊。其工作环境为肠道环境。该可驱动的释药取样一体胶囊具体包括外壳1、套筒2、柱塞3和取样针4。
外壳1为头部封闭、尾部设有底盖的中空圆柱体结构。具体的，外壳1的外侧壁上设有第一外螺纹11，内侧壁上设有内螺纹12；第一外螺纹11和内螺纹12的旋向相同；第一外螺纹11布满外壳1的外侧壁，内螺纹12只有一段，且靠近外壳1的头部设置。第一外螺纹11和内螺纹12均具有磁性。为了减轻整个胶囊的重量，在加工过程中，可以采用塑料加工外壳1的本体，然后在塑料的外部和内部嵌套磁性材料加工的具有第一外螺纹11和内螺纹12的嵌套，从而使第一外螺纹11和内螺纹12均具有磁性。需要说明的是，还可以直接采用磁性材料加工外壳1，从而保证第一外螺纹11和内螺纹12均具有磁性，具体的加工方法根据实际进行选择，此处不做限定。
外壳1的尾部端面设有微刺13，顶盖上设有通孔，通孔处设有取样针4，取样针4的内腔与外壳1的内腔连通。为了减少零部件，取样针4与外壳1一体成型。侧壁的底部设有第一出药口。第一出药口为沿外壳1的周向均布的多个第一径向孔14。
外壳1内设有套筒2和柱塞3。其中，套筒2为一端具有开口的圆筒。套筒2与外壳1滑动连接。具体的，套筒2的外侧壁上设有沿轴向延伸的凸棱，外壳1的内侧壁上设有与凸棱相适配的滑槽15。由此，可以防止套筒2滑动时转动。外壳1的内侧壁上还设有环槽16，套筒2的头部设有与环槽16相适配的凸台21，凸台21能够沿环槽16的轴向滑动。由此，可以增强导向性。需要说明的是，此处的环槽16也可以为退刀槽。
柱塞3包括螺纹段31和光轴段32，螺纹段31上设有与内螺纹12相适配的第二外螺纹33，第二外螺纹33也具有磁性。光轴段32伸入套筒2内部并能够沿套筒2的轴向滑动，且光轴段32的底面、套筒2的底面和套筒2的内侧壁围成储药腔5。储药腔5的作用相当于药仓，液态药物储存在其内。储药腔5的侧壁上设有第二出药口。第二出药口为多个第二径向孔51。第二径向孔51的数量与第一径向孔14的数量相等。
柱塞3能够推动套筒2沿外壳1的轴向运动，当套筒2未被推向外壳1底部时，第二径向孔51与第一径向孔14相互错开，第二径向孔51被外壳1的侧壁遮挡，储药腔55的药物无法流出。当套筒2运行至外壳1的底部时，第二径向孔51与第一径向孔14的位置一一对应，此时储药腔5与外部连通，柱塞3推动储药腔5内的液态药物流出。需要说明的是，安装完成后的胶囊是封闭的。
本申请实施例1的工作原理如下：
本申请实施例可驱动释的药取样一体胶囊，由外部磁驱系统操控，外部磁驱系统可以施加正向和反向的旋转磁场。外部磁驱系统为现有技术此处不再详述。
为了到达目标位置，外部磁控系统施加正向旋转磁场，胶囊整体旋转，在外壳1表面的第一外螺纹11的作用下向前旋进，此时，外壳1内的柱塞3的前进趋势也是靠近取样针4的方向，因而此时不会挤压药水。当胶囊整体运动到目标位置后，可以选择进行组织采样或者药物释放。需要说明的是，可以依次完成组织采样和释药操作，两者不分先后，也可以仅完成组织采样或释药操作。
若进行组织采样，则控制外部磁驱系统调整磁场旋转方向，使取样针4朝向取样区域，然后使胶囊向前旋进，直至取样针4刺入组织，然后使磁场反向旋转，胶囊反向旋转取样针4退出，部分组织将残留在取样针4内，从而完成取样操作。
若进行释药操作，则需要磁场反向旋转。胶囊倒退到附近组织壁面上，胶囊底部的微刺13扎入组织，使外壳1固定。然后使磁场继续反向旋转，胶囊内部的柱塞3向底部旋进。由于储药腔5内的液体的不可压缩性，套筒2会先被推出，套筒2上的第二径向孔51与外壳1上的第一径向孔14对齐。然后，柱塞3继续向底部旋进，慢慢将储药腔55内部的药水推出胶囊，完成药物释放。
实施例2：
参照图2，本申请的实施例还提供了一种可驱动的释药取样一体胶囊。其工作环境为肠道环境。实施例2和实施例的区别仅在于：实施例2中采用取样钳6替代了取样针4。具体的，柱塞3的头部设有驱动杆7，外壳1的头部设有限位套8，驱动杆7远离柱塞3的一端伸出限位套8后连接取样钳6，当柱塞3轴向运动时，带动驱动杆7，进而驱动取样钳6闭合完成取样。需要说明的是，为了减少零部件，限位套8与外壳1一体成型。
本申请实施例2的工作原理如下：
本申请实施例可驱动释的药取样一体胶囊，也由外部磁驱系统操控。其驱动原理和释药原理均与实施例1相同，此处不再详述。
进行组织采样时，控制外部磁驱系统调整磁场旋转方向，使取样钳6张开并充分嵌入组织，此时取样钳6内部含有组织块，外部被组织包裹，然后使磁场反向旋转，柱塞3传递给取样钳6的牵引力会使取样钳6先闭合，然后，由于取样钳6与组织之间的阻力减小，继续反向驱动胶囊，取样钳6会从组织中脱离，完成取样过程。
以上，仅为本申请的具体实施方式，但本申请的保护范围并不局限于此，任何在本申请揭露的技术范围内的变化或替换，都应涵盖在本申请的保护范围之内。因此，本申请的保护范围应该以权利要求的保护范围为准。

Claims (10)

  1. 一种可驱动的释药取样一体胶囊，其特征在于，包括外壳；所述外壳的外侧壁上设有第一外螺纹，内侧壁上设有内螺纹；所述第一外螺纹和所述内螺纹的旋向相同；所述外壳的尾部设有第一出药口，头部设有取样针；所述外壳内设有套筒和柱塞；所述套筒为一端具有开口的圆筒；所述套筒与所述外壳滑动连接；所述柱塞包括螺纹段和光轴段；所述螺纹段上设有与所述内螺纹相适配的第二外螺纹，所述光轴段伸入套筒内部并能够沿套筒的轴向滑动，且所述光轴段的底面、所述套筒的底面和所述套筒的内侧壁围成储药腔；所述储药腔的侧壁上设有第二出药口；所述柱塞能够推动所述套筒沿外壳的轴向运动；当所述套筒运行至所述外壳的底部时，所述第一出药口和所述第二出药口连通；所述第一外螺纹和第二外螺纹均具有磁性。
  2. 根据权利要求1所述的可驱动的释药取样一体胶囊，其特征在于，所述第一出药口为设置在所述外壳的侧壁底部的多个第一径向孔；多个所述第一径向孔沿所述外壳的周向均布；所述第二出药口为设置在所述套筒的侧壁上的多个第二径向孔；当所述套筒运行至所述外壳的底部时，所述第二径向孔与所述第一径向孔的位置一一对应。
  3. 根据权利要求1所述的可驱动的释药取样一体胶囊，其特征在于，所述套筒的外侧壁上设有沿轴向延伸的凸棱，所述外壳的内侧壁上设有与所述凸棱相适配的滑槽。
  4. 根据权利要求1所述的可驱动的释药取样一体胶囊，其特征在于，所述外壳的尾部端面上设有微刺。
  5. 根据权利要求1所述的可驱动的释药取样一体胶囊，其特征在于，所述外壳的内侧壁上还设有环槽，所述套筒的头部设有与所述环槽相适配的凸台，所述凸台能够沿所述环槽的轴向滑动。
  6. 一种可驱动的释药取样一体胶囊，其特征在于，包括外壳；所述外壳的外侧壁上设有第一外螺纹，内侧壁上设有内螺纹；所述第一外螺纹和所述内螺纹的旋向相同；所述外壳的尾部设有第一出药口；所述外壳内设有套筒和柱塞；所述套筒为一端具有开口的圆筒；所述套筒与所述外壳滑动连接；所述柱塞包括螺纹段和光轴段；所述螺纹段上设有与所述内螺纹相适配的第二外螺纹，所述光轴段伸入套筒内部并能够沿套筒的轴向滑动，且所述光轴段的底面、所述套筒的底面和所述套筒的内侧壁围成储药腔；所述储药腔的侧壁上设有第二出药口；所述柱塞能够推动所述套筒沿外壳的轴向运动；当所述套筒运行至所述外壳的底部时，所述第一出药口和所述第二出药口连通；所述柱塞的头部设有驱动杆；外壳的头部设有限位套；所述驱动杆远离所述柱塞的一端伸出所述限位套后连接取样钳；所述第一外螺纹和第二外螺纹均具有磁性。
  7. 根据权利要求6所述的可驱动的释药取样一体胶囊，其特征在于，所述第一出药口为设置在所述外壳的侧壁底部的多个第一径向孔；多个所述第一径向孔沿所述外壳的周向均布；所述第二出药口为设置在所述套筒的侧壁上的多个第二径向孔；当所述套筒运行至所述外壳的底部时，所述第二径向孔与所述第一径向孔的位置一一对应。
  8. 根据权利要求6所述的可驱动的释药取样一体胶囊，其特征在于，所述套筒的外侧壁上设有沿轴向延伸的凸棱，所述外壳的内侧壁上设有与所述凸棱相适配的滑槽。
  9. 根据权利要求6所述的可驱动的释药取样一体胶囊，其特征在于，所述外壳的尾部端面上设有微刺。
  10. 根据权利要求6所述的可驱动的释药取样一体胶囊，其特征在于，所述外壳的内侧壁上还设有环槽，所述套筒的头部设有与所述环槽相适配的凸台，所述凸台能够沿所述环槽的轴向滑动。
PCT/CN2023/136582 2023-06-16 2023-12-05 可驱动的释药取样一体胶囊 Ceased WO2024255152A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202310715548.3A CN116688335B (zh) 2023-06-16 2023-06-16 可驱动的释药取样一体胶囊
CN202310715548.3 2023-06-16

Publications (1)

Publication Number Publication Date
WO2024255152A1 true WO2024255152A1 (zh) 2024-12-19

Family

ID=87827328

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/136582 Ceased WO2024255152A1 (zh) 2023-06-16 2023-12-05 可驱动的释药取样一体胶囊

Country Status (2)

Country Link
CN (1) CN116688335B (zh)
WO (1) WO2024255152A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120938503A (zh) * 2025-10-15 2025-11-14 山东万海生物科技有限公司 一种取样检测装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116688335B (zh) * 2023-06-16 2025-09-30 深圳先进技术研究院 可驱动的释药取样一体胶囊

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0460327A1 (en) * 1990-07-06 1991-12-11 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
CN1820798A (zh) * 2006-01-28 2006-08-23 重庆大学 胶囊式消化道药物释放及采样装置
CN110038211A (zh) * 2018-01-16 2019-07-23 上海安翰医疗技术有限公司 消化道施药装置及其施药胶囊
CN111685715A (zh) * 2020-06-13 2020-09-22 西安交通大学 一种可视化消化道采样释药胶囊
CN113081075A (zh) * 2021-03-09 2021-07-09 武汉大学 一种具有主动式活检与施药功能的磁控胶囊
CN113545812A (zh) * 2021-07-21 2021-10-26 湖北汽车工业学院 一种肠道用凸轮式定点操作装置
CN113576551A (zh) * 2021-07-21 2021-11-02 湖北汽车工业学院 一种肠道用螺旋式定点操作机构
CN114938938A (zh) * 2022-04-29 2022-08-26 上海理工大学 基于多轴连杆机构的非同迹式胶囊状活检机器人
CN116688335A (zh) * 2023-06-16 2023-09-05 深圳先进技术研究院 可驱动的释药取样一体胶囊

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9445711B2 (en) * 2012-05-09 2016-09-20 Carnegie Mellon University System and method to magnetically actuate a capsule endoscopic robot for diagnosis and treatment
CN110037746B (zh) * 2018-01-16 2024-01-09 上海安翰医疗技术有限公司 外磁场控制的胶囊式消化道取液装置及其胶囊本体
CN109330627B (zh) * 2018-10-09 2021-02-09 安翰科技(武汉)股份有限公司 可同步或异步完成采样和释药的胶囊系统

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0460327A1 (en) * 1990-07-06 1991-12-11 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
CN1820798A (zh) * 2006-01-28 2006-08-23 重庆大学 胶囊式消化道药物释放及采样装置
CN110038211A (zh) * 2018-01-16 2019-07-23 上海安翰医疗技术有限公司 消化道施药装置及其施药胶囊
CN111685715A (zh) * 2020-06-13 2020-09-22 西安交通大学 一种可视化消化道采样释药胶囊
CN113081075A (zh) * 2021-03-09 2021-07-09 武汉大学 一种具有主动式活检与施药功能的磁控胶囊
CN113545812A (zh) * 2021-07-21 2021-10-26 湖北汽车工业学院 一种肠道用凸轮式定点操作装置
CN113576551A (zh) * 2021-07-21 2021-11-02 湖北汽车工业学院 一种肠道用螺旋式定点操作机构
CN114938938A (zh) * 2022-04-29 2022-08-26 上海理工大学 基于多轴连杆机构的非同迹式胶囊状活检机器人
CN116688335A (zh) * 2023-06-16 2023-09-05 深圳先进技术研究院 可驱动的释药取样一体胶囊

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120938503A (zh) * 2025-10-15 2025-11-14 山东万海生物科技有限公司 一种取样检测装置
CN120938503B (zh) * 2025-10-15 2026-01-30 山东万海生物科技有限公司 一种取样检测装置

Also Published As

Publication number Publication date
CN116688335B (zh) 2025-09-30
CN116688335A (zh) 2023-09-05

Similar Documents

Publication Publication Date Title
WO2024255152A1 (zh) 可驱动的释药取样一体胶囊
KR101619931B1 (ko) 캡슐형 마이크로 로봇 및 사용방법
EP1765158B1 (en) Delivery device
CN107374792B (zh) 一种一体式分层支架植入器
MXPA03010227A (es) Aguja combinada y dispositivo dilatador para la cateterizacion arterial y de la vena central.
US7678088B2 (en) Portkatheter
CN109173027A (zh) 一种内窥镜下的一次性远程注射针
EP3789003B1 (en) Duodenum implanted jejunum cannula releasing system
CN118593089A (zh) 一种远程心腔内可调弯鞘管装置及系统
US10667842B2 (en) Pericardial needle mechanism
US12251162B2 (en) Bending mechanism and surgical robotic arm including the same
JP2024533723A (ja) 医療用スネア装置
CN111973237A (zh) 一种具有组织样本采集回收功能的切割机器人
CN118141306A (zh) 施药胶囊机器人及其控制方法
CN111772558B (zh) 一种消化道病变内镜用定位装置
WO2022236263A1 (en) Multi-lumen catheters
RU2260448C1 (ru) Устройство для введения лекарственных веществ
CN209221308U (zh) 一种内窥镜下的一次性远程注射针
WO2023077913A1 (zh) 蛇骨单元、蛇骨管、插入导管及电子内窥镜
CN119367667B (zh) 用于结直肠肛门的机械减压式送药及微创手术操作的装置
JP2019509815A (ja) 導入器及びその使用方法
CN207575509U (zh) 预充式注射器及套筒
CN207734419U (zh) 自带阻菌功能的保护帽及使用该保护帽的预充式注射器
CN217186056U (zh) 胶囊型医疗器械
CN115444524B (zh) 穿刺器及手术机器人系统

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23941373

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE