WO2024090875A1

WO2024090875A1 - System, apparatus, and method for adaptive brain stimulation control based on neural signal analysis

Info

Publication number: WO2024090875A1
Application number: PCT/KR2023/016007
Authority: WO
Inventors: 김기현; 최영진; 김철
Original assignee: 한국전기연구원
Priority date: 2022-10-27
Filing date: 2023-10-17
Publication date: 2024-05-02
Also published as: KR20240059466A

Abstract

The present invention relates to a system, apparatus, and method for brain stimulation control, and more specifically, to a system, apparatus, and method for adaptive brain stimulation control based on neural signal analysis, wherein neural stimulation signals are adaptively applied on the basis of the analyses of neural signals of a patient, and thus a reduction in treatment effect and damage to neural tissues caused by regular neural stimulation can be suppressed and the interval for battery replacement can be increased. Disclosed is a neural stimulation system characterized by comprising: a neural signal detection apparatus comprising a neural signal detection unit partially or fully inserted into the patient's brain to detect neural signals, and a first wireless communication unit which wirelessly transmits neural stimulation data, calculated on the basis of the neural signals, for neural stimulation of the patient; and a neural stimulation apparatus comprising a second wireless communication unit which receives the neural stimulation data from the neural signal detection apparatus, and a neural stimulation performance unit which performs neural stimulation by applying neural stimulation signals calculated on the basis of the neural stimulation data to the patient's brain.

Description

Adaptive brain stimulation control system, device and method based on neural signal analysis

The present invention relates to a brain stimulation control system, device, and method. More specifically, the present invention relates to a brain stimulation control system, device, and method, and more specifically, to adaptively apply a nerve stimulation signal based on analysis of the patient's nerve signal, thereby reducing the therapeutic effect and damaging the nerve tissue due to constant nerve stimulation. It relates to an adaptive brain stimulation control system, device, and method based on neural signal analysis that can suppress and extend the battery replacement cycle.

Recently, social interest in neurological diseases such as dementia has been increasing, and in relation to this, treatment techniques have been attempted to improve conditions by stimulating specific optic nerves for Parkinson's disease, epilepsy, etc.

For example, in the case of Parkinson's disease, as can be seen in Figure 1, a needle for nerve stimulation is inserted into the patient's sub-thalamic nucleus (STN), and the needle and wire for nerve stimulation ( A treatment technique is being used to alleviate the condition and enable daily life by applying an electrical stimulation signal of about 130 Hz from an implantable body connected through a wire.

However, in the case of this prior art, a significant effect is shown immediately after the procedure, but not only does the treatment effect by electrical stimulation decrease over time, but there is a problem that tissue damage and necrosis may occur due to constant nerve stimulation. It is becoming.

In addition, in the prior art, the inconvenience of having to repeatedly undergo reoperation to replace the battery as the battery of the implantable body is consumed is consumed.

Furthermore, in the above-described prior art, there is also a need for a method to continuously improve the treatment effect through upgrading the treatment algorithm of the implantable body.

Accordingly, the treatment effect can be maintained continuously even after the procedure, tissue damage and necrosis due to constant nerve stimulation can be prevented, repeated reoperations for battery replacement can be reduced, and further upgrades to treatment algorithms, etc. There is a continuous need for measures to continuously improve treatment effectiveness, but an appropriate solution has not yet been proposed.

The present invention was developed to solve the above problems, and can continuously maintain the treatment effect even after the procedure, prevent tissue damage and necrosis due to constant nerve stimulation, and also enable repeated reoperation for battery replacement. The purpose is to disclose a brain stimulation control system, device, and method that can reduce and continuously improve treatment effects through upgrades to treatment algorithms, etc.

Other detailed purposes of the present invention will be clearly understood and understood by experts or researchers in this technical field through the detailed contents described below.

A nerve stimulation system according to an embodiment of the present invention to solve the above problems includes a nerve signal detection unit that is partially or fully inserted into the patient's brain to detect nerve signals, and a nerve signal detection unit that detects nerve signals, and A nerve signal detection device including a first wireless communication unit that wirelessly transmits nerve stimulation data for nerve stimulation to a patient; And, a second wireless communication unit that receives the nerve stimulation data from the nerve signal detection device, and a nerve stimulation performing unit that applies a nerve stimulation signal calculated based on the nerve stimulation data to the brain of the patient to perform nerve stimulation. It is characterized in that it includes a nerve stimulator.

Here, the nerve signal detection unit may include a needle-shaped electrode that senses the patient's nerve signal, and a nerve signal processor that calculates the nerve stimulation data based on the nerve signal sensed by the needle-shaped electrode.

At this time, the nerve signal processing unit applies a predetermined first algorithm to the nerve signal to adaptively calculate the nerve stimulation data, and the nerve stimulation performing unit generates the nerve stimulation signal based on the nerve stimulation data. Nerve stimulation can be performed by applying it to the patient's brain.

Additionally, in the neural signal detection device, the first algorithm can be updated and applied with the second algorithm transmitted through the first wireless communication unit.

In addition, the nerve stimulation performing unit includes a nerve stimulation signal calculation unit that adaptively calculates the nerve stimulation signal based on the nerve stimulation data, and a nerve stimulation signal to apply the nerve stimulation signal to perform nerve stimulation on the patient's brain. It may include a nerve stimulation application unit.

Additionally, the nerve stimulation performing unit may generate ultrasound based on the nerve stimulation data and apply it to the patient's brain to perform nerve stimulation.

At this time, a plurality of ultrasound generators are arranged in the nerve stimulation performing unit to focus and apply the ultrasound to a specific area of the patient's brain.

Additionally, the nerve stimulation signal calculation unit may adaptively calculate the nerve stimulation signal by applying a predetermined first algorithm to the nerve stimulation data.

Additionally, in the neurostimulation device, the first algorithm can be updated and applied with the second algorithm transmitted through the second wireless communication unit.

Additionally, the nerve stimulation performing unit may generate an electrical signal based on the nerve stimulation data and apply it to the patient's brain through the needle-shaped electrode to perform nerve stimulation.

At this time, the needle-shaped electrode is provided with a plurality of channels arranged at predetermined intervals, some channels among the plurality of channels are assigned as channels for sensing nerve signals, and some channels among the plurality of channels are nerve signals. It can be assigned to a channel for performing stimulation.

Additionally, the needle-shaped electrode can time-divide the operation section to sense the nerve signal in the first section and perform nerve stimulation for the patient in the second section.

Additionally, the nerve stimulation signal may be generated by analyzing the morphology of a nerve firing signal among the nerve signals and adjusting nerve stimulation parameters for the patient.

In addition, the nerve stimulation method according to another aspect of the present invention includes the steps of wirelessly receiving, by a nerve stimulation device, nerve stimulation data for nerve stimulation for the patient calculated based on the patient's nerve signals; and performing nerve stimulation by applying a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain.

Accordingly, in the adaptive brain stimulation control system, device, and method based on nerve signal analysis according to an embodiment of the present invention, the treatment effect can be continuously maintained even after the procedure, and tissue damage and necrosis due to constant nerve stimulation can be prevented. can be prevented, and repeated reoperations for battery replacement can be reduced, and furthermore, the treatment effect can be continuously improved through upgrades to the treatment algorithm.

The accompanying drawings, which are included as part of the detailed description to aid understanding of the present invention, provide embodiments of the present invention, and together with the detailed description, explain the technical idea of the present invention.

1 is an exemplary diagram of a nerve stimulation device according to the prior art.

Figure 2 is a block diagram of a nerve stimulation system according to an embodiment of the present invention.

3 to 6 are diagrams illustrating the specific configuration and operation of a nerve stimulation system according to an embodiment of the present invention.

Figures 7 and 8 are diagrams illustrating a configuration for performing nerve stimulation using ultrasound in a nerve stimulation system according to an embodiment of the present invention.

Figure 9 is a diagram illustrating a neural firing signal according to an embodiment of the present invention.

10 to 12 are diagrams illustrating adjustment of nerve stimulation parameters based on nerve firing signals according to an embodiment of the invention.

Figure 13 is a diagram illustrating adjustment of nerve stimulation parameters based on the frequency characteristics of a nerve signal according to an embodiment of the invention.

Figure 14 is a diagram illustrating adjustment of nerve stimulation parameters based on pattern classification of nerve signals according to an embodiment of the invention.

Figure 15 is a flowchart of a nerve stimulation method according to an embodiment of the present invention.

The present invention can be modified in various ways and can have various embodiments. Hereinafter, specific embodiments will be described in detail based on the accompanying drawings.

The following examples are provided to provide a comprehensive understanding of the methods, devices and/or systems described herein. However, this is only an example and the present invention is not limited thereto.

In describing the embodiments of the present invention, if it is determined that a detailed description of the known technology related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description will be omitted. In addition, the terms described below are terms defined in consideration of functions in the present invention, and may vary depending on the intention or custom of the user or operator. Therefore, the definition should be made based on the contents throughout this specification. The terminology used in the detailed description is only for describing embodiments of the present invention and should in no way be limiting. Unless explicitly stated otherwise, singular forms include plural meanings. In this description, expressions such as “comprising” or “including” are intended to indicate certain features, numbers, steps, operations, elements, parts or combinations thereof, and one or more than those described. It should not be construed to exclude the existence or possibility of any other characteristic, number, step, operation, element, or part or combination thereof.

In addition, terms such as first, second, etc. may be used to describe various components, but the components are not limited by the terms, and the terms are used for the purpose of distinguishing one component from another component. It is used only as

Below, exemplary embodiments of an adaptive brain stimulation control system, device, and method based on neural signal analysis according to the present invention will be described in detail with reference to the accompanying drawings.

First, Figure 2 illustrates a block diagram of the nerve stimulation system 100 according to an embodiment of the present invention. As can be seen in Figure 2, the nerve stimulation system 100 according to an embodiment of the present invention includes a nerve signal detection unit 111 that is partially or fully inserted into the patient's brain to detect nerve signals and the nerve A nerve signal detection device 110 including a first wireless communication unit 112 for wirelessly transmitting nerve stimulation data for nerve stimulation for the patient calculated based on the signal, and the nerve signal detection device 110 from the nerve signal detection device 110. A nerve stimulation device including a second wireless communication unit 121 that receives stimulation data and a nerve stimulation performing unit 122 that performs nerve stimulation by applying a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain. It may be configured to include (120).

Here, the nerve signal detection unit 111 includes a needle-shaped electrode 111a that senses the patient's nerve signal, and a device that calculates the nerve stimulation data based on the nerve signal sensed by the needle-shaped electrode 111a. It may include a neural signal processing unit 111b.

At this time, the nerve signal processing unit 111b applies a predetermined first algorithm to the nerve signal to adaptively calculate the nerve stimulation data, and the nerve stimulation performing unit 122 calculates the nerve stimulation data based on the nerve stimulation data. Nerve stimulation can be performed by generating a nerve stimulation signal and applying it to the patient's brain.

Additionally, the neural signal detection device 110 may update and apply the first algorithm with the second algorithm transmitted through the first wireless communication unit 112.

In addition, the nerve stimulation performing unit 122 includes a nerve stimulation signal calculation unit 122a that adaptively calculates the nerve stimulation signal based on the nerve stimulation data, and applies the nerve stimulation signal to the patient's brain. It may include a nerve stimulation application unit 122b that performs nerve stimulation.

Additionally, the nerve stimulation performing unit 122 may generate ultrasound based on the nerve stimulation data and apply it to the patient's brain to perform nerve stimulation.

At this time, a plurality of ultrasound generators are arranged in the nerve stimulation performing unit 122 to focus and apply the ultrasound to a specific area of the patient's brain.

Additionally, the nerve stimulation signal calculation unit 122a may adaptively calculate the nerve stimulation signal by applying a predetermined first algorithm to the nerve stimulation data.

Additionally, in the nerve stimulator 120, the first algorithm can be updated and applied with the second algorithm transmitted through the second wireless communication unit 121.

Additionally, the nerve stimulation performing unit 122 may generate an electrical signal based on the nerve stimulation data and apply it to the patient's brain through the needle-shaped electrode 111a to perform nerve stimulation.

At this time, the needle-shaped electrode 111a is provided with a plurality of channels arranged at predetermined intervals, some channels among the plurality of channels are assigned as channels for sensing nerve signals, and some of the plurality of channels A channel may be assigned as a channel for performing nerve stimulation.

In addition, the needle-shaped electrode 111a can time-divide the operation section to sense the nerve signal in the first section and perform nerve stimulation for the patient in the second section.

Below, the nerve stimulation system 100 according to an embodiment of the present invention will be described in more detail by dividing it into each component with reference to each drawing.

First, as can be seen in FIGS. 2 and 3, the nerve signal detection unit 111 of the nerve signal detection device 110 is partially or fully inserted into the patient's brain to detect nerve signals.

At this time, as can be seen in FIG. 4, the nerve signal detection unit 111 includes a needle-shaped electrode 111a that is inserted into the nervous tissue of the brain, such as the patient's subthalamic nucleus (STN), and senses the patient's nerve signals; Including a nerve signal processing unit 111b that calculates nerve stimulation data for the patient based on the nerve signal sensed by the needle-shaped electrode 111a, detecting nerve signals occurring in the patient's nerve tissue and performing nerve stimulation Data can be calculated.

However, detecting nerve signals from the subthalamic nucleus (STN) of a patient as described above is only an example of the present invention, and the present invention is not limited thereto.

In addition, the nerve signal processing unit 111b calculates the nerve stimulation data based on the nerve signal. At this time, the nerve stimulation data may be data representing the characteristics of the nerve signal (for example, in FIG. 9 amplitude of the first peak signal in the neural firing signal, time interval between the first peak signal and the subsequent second peak signal, slew rate of the second peak signal, etc.), the present invention is not necessarily limited thereto. In addition, the specific content or format of the nerve stimulation data can be configured so that a nerve stimulation signal for stimulating the patient's brain can be effectively calculated based on the nerve stimulation data.

Furthermore, in the present invention, the nerve stimulation data is data indicating whether nerve stimulation is required for the patient, or the nerve stimulation data can be used in various ways, such as using the nerve signal itself as the nerve stimulation data or digitally converting and transmitting the nerve stimulation data. It is also possible to organize data.

Subsequently, the first wireless communication unit 112 wirelessly transmits nerve stimulation data for nerve stimulation for the patient calculated based on the nerve signal.

At this time, the first wireless communication unit 112 can transmit the nerve stimulation data using various types of wireless communication technologies such as mobile communication such as Bluetooth, Wi-Fi, LTE, and NFC, and further, some Wired communication may be used in the section.

Accordingly, the nerve signal detection device 110 detects nerve signals from the patient's brain using the nerve signal detection unit 111 and calculates nerve stimulation data through the first wireless communication unit 112. Nerve stimulation data can be wirelessly transmitted to the nerve stimulation device 120 to perform nerve stimulation on the patient.

More specifically, in the nerve signal detection device 110, a needle-shaped electrode 111a is inserted into the patient's brain to detect nerve signals or perform nerve stimulation through a plurality of channels. In this case, the nerve signal detection device 110 (110) can control nerve stimulation in the nerve stimulator 120 while performing wireless communication with the nerve stimulator 120 through the first wireless communication unit 112, and process an algorithm for nerve stimulation through this. Significant power consumption consumed in the process can be effectively reduced.

In addition, as can be seen in Figure 1, in conventional deep brain stimulation (DBS), a stimulating device is inserted under the skin of the patient's chest, and the wire connected to the needle electrode is also inserted under the scalp along the subcutaneous layer of the neck. This must result in the complexity of the surgery and inconvenience in the patient's daily life. However, the present invention can effectively solve these problems, and furthermore, the nerve signals recorded in the external nerve stimulator 120 and Through artificial intelligence learning or a series of analysis processes through stimulation events, the stimulation control algorithm can be optimized for each individual and continuously upgraded, thereby reducing the side effects of nerve stimulation treatment and improving the treatment effect.

Furthermore, in the present invention, it is possible to monitor deep brain nerve activity signals as if monitoring the patient's vital signals (e.g., heart rate, blood oxygen saturation, blood pressure, respiratory rate, ECG, etc.), which can be used in hospitals. In addition, various uses are possible, such as use as a personal healthcare device.

In addition, in Figure 3, the nerve stimulation device 120 can perform nerve stimulation for the patient using ultrasound, but the present invention is not necessarily limited thereto, and the nerve signal is detected without performing nerve stimulation using ultrasound. When the nerve signal sensed by the needle-shaped electrode 111a of the device 110 is wirelessly transmitted, a stimulation control algorithm is performed, the nerve stimulation parameters are adjusted and wirelessly transmitted back to the nerve signal detection device 110, the nerve The signal detection device 110 can use this to perform electrical stimulation on the patient.

On the other hand, when ultrasonic stimulation is performed using the nerve stimulator 120, the nerve signal detection device 110 is used only for sensing nerve signals, and nerve stimulation can be performed through the nerve stimulator 120.

At this time, when the nerve signal detection device 110 senses a nerve signal and sends a signal to the nerve stimulator 120 through wireless communication, the nerve stimulator 120 performs a stimulation control algorithm, and according to the results, It is also possible to perform nerve stimulation using ultrasound by adjusting nerve stimulation parameters.

Furthermore, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve signal detection device 110 adaptively calculates the nerve stimulation data using a predetermined first algorithm and wirelessly transmits the nerve stimulation data, The nerve stimulation device 120 may generate the nerve stimulation signal based on the nerve stimulation data and apply it to the patient's brain to perform nerve stimulation. At this time, the first algorithm will be described later with reference to FIG. 9 and below.

At this time, as can be seen in FIG. 4, the neural signal detection device 110 may update and apply the first algorithm with the second algorithm transmitted through the first wireless communication unit 112, but the present invention This is not necessarily limited to this, and it is also possible to update the first algorithm in the neural signal detection device 110 through wired communication or direct connection.

In addition, as can be seen in FIG. 4, the nerve signal detection device 110 is equipped with a power supply unit 113, such as a battery, to supply power for driving the nerve signal detection device 110. In the present invention, The nerve signal detection device 110 senses the nerve signal or processes it and transmits it wirelessly, and the configuration for nerve stimulation for the patient is provided in a separate nerve stimulation device 120, so the nerve signal detection device 110 ), it is possible to effectively extend the life of batteries, etc. by reducing the power consumed.

Subsequently, the nerve stimulation device 120 receives the nerve stimulation data from the nerve signal detection device 110 through the second wireless communication unit 121.

Accordingly, as can be seen in FIG. 5, the nerve stimulation performing unit 122 applies a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain to perform nerve stimulation.

More specifically, a user of the nerve stimulation system 100, such as a patient, the patient's guardian, or a medical staff member, performs nerve stimulation on the patient included in the nerve stimulation data wirelessly transmitted from the nerve signal detection unit 110. By receiving an alarm, etc., nerve stimulation for the patient can be performed using the nerve stimulation device 120.

At this time, as can be seen in FIG. 6, the nerve stimulation performing unit 122 includes a nerve stimulation signal calculating unit 122a that adaptively calculates the nerve stimulation signal based on the nerve stimulation data, and the nerve stimulation It may include a nerve stimulation application unit 122b that applies a signal to perform nerve stimulation to the patient's brain.

More specifically, the nerve stimulation performing unit 122 may generate ultrasound based on the nerve stimulation data and apply it to the patient's brain to perform nerve stimulation.

In this case, as can be seen in FIG. 5, the nerve stimulation performing unit 122 can perform nerve stimulation by applying ultrasound to the patient's brain without passing through the needle-shaped electrode 111a inserted into the patient's brain. .

Furthermore, as can be seen in FIGS. 7A and 7B, a plurality of ultrasound generators are arranged in the nerve stimulation performing unit 122 to focus and apply the ultrasound to a specific area of the patient's brain.

More specifically, as can be seen in FIGS. 7A and 7B, the nerve stimulation performing unit 122 can convert an electrical signal into ultrasound using a plurality of PZT elements and apply it to the patient's head. By adjusting the delay in the plurality of PZT elements, the ultrasound applied from the plurality of PZT elements can be controlled to focus on a specific area, thereby efficiently performing nerve stimulation.

In addition, as can be seen in FIGS. 8A to 8C, the nerve stimulation performing unit 122 includes classification by mode of ultrasound (FIG. 8A), electronic beamforming (FIG. 8B), and ultrasound transmission apodization (FIG. 8B). Using Figure 8c), ultrasound can be applied by effectively focusing it on a specific part of the patient's brain while suppressing secondary and higher order lobes.

Furthermore, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve stimulation device 120 adaptively generates the nerve stimulation signal using a predetermined first algorithm and applies it to the patient's brain. Nerve stimulation can be performed. At this time, the first algorithm will be described later with reference to FIGS. 9 to 14.

At this time, as can be seen in FIG. 6, the nerve stimulator 120 may update and apply the first algorithm with the second algorithm transmitted through the second wireless communication unit 121, but the present invention It is not necessarily limited to this, and it is also possible to update the first algorithm in the neurostimulation device 120 through wired communication or direct connection.

Additionally, the nerve stimulation performing unit 120 may generate an electrical signal based on the nerve stimulation data and apply it to the patient's brain through the needle-shaped electrode 111a to perform nerve stimulation.

In this case, the user contacts the nerve stimulation performing unit 120 with the nerve signal detecting unit 110 to connect the electrode provided in the nerve stimulation performing unit 120 and the nerve signal detecting unit 110. By connecting the electrodes, the nerve stimulation signal generated by the nerve stimulation performing unit 120 is transmitted to the needle-shaped electrode 111a and applied to the patient's brain to perform nerve stimulation.

Furthermore, the needle-shaped electrode 111a is provided with a plurality of channels arranged at predetermined intervals, and some channels among the plurality of channels are assigned as channels for sensing nerve signals, and some of the plurality of channels A channel may be assigned as a channel for performing nerve stimulation.

At this time, it is possible to time-divide the operation section for the needle-shaped electrode 111a so that the nerve signal is sensed in the first section and nerve stimulation of the patient is performed in the second section.

Additionally, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve stimulation signal is generated by analyzing the morphology of the nerve firing signal among the nerve signals and adjusting the nerve stimulation parameters for the patient. You can.

Additionally, the nerve stimulation system 100 analyzes the morphology of nerve firing signals among the nerve signals detected by the nerve signal detection unit 110 to adjust nerve stimulation parameters for the patient.

More specifically, in the nerve stimulation system 100, as can be seen in FIG. 9, the amplitude of the first peak signal among the nerve firing signals (Amplitude in FIG. 9), the second peak following the first peak signal The nerve stimulation parameters for the patient can be adjusted by considering one or more of the time interval between signals (Width in FIG. 9) and the rise rate (Slew Rate in FIG. 9) of the second peak signal.

More specifically, the nerve stimulation system 100 can adjust one or more of the current level, voltage level, stimulation time, and stimulation frequency of the nerve stimulation.

Accordingly, in the prior art, a significant effect is shown immediately after the procedure, but not only does the therapeutic effect of electrical stimulation decrease over time, but tissue damage and necrosis may occur due to constant nerve stimulation, and further battery consumption may occur. Accordingly, there was a problem that reoperations for battery replacement had to be performed repeatedly. However, the adaptive nerve stimulation system 100 according to an embodiment of the present invention adjusts nerve stimulation parameters adaptively based on the patient's nerve firing signal. , it suppresses the reduction in treatment effect and damage to nerve tissue caused by constant nerve stimulation, reduces battery consumption, and extends the battery replacement cycle.

More specifically, in the nerve stimulation system 100 according to an embodiment of the present invention, as can be seen in FIG. 10, when the amplitude of the first peak signal is greater than a predetermined first reference value, the nerve for the patient Stimulation parameters can be adjusted.

For example, as can be seen in Figure 10, when a nerve signal is detected in the nerve stimulation system 100 according to an embodiment of the present invention ((a) of Figure 10), the nerve signal is processed through processing. Calculate the amplitude of the first peak signal from the nerve firing signal (Figure 10(b)), and if the amplitude of the first peak signal is greater than the first predetermined reference value, the nerve for the patient Stimulation parameters are adjusted (Figure 10(c)).

Additionally, in the nerve stimulation system 100 according to an embodiment of the present invention, as can be seen in FIG. 11, the time interval between the first peak signal and the subsequent second peak signal is less than a predetermined second reference value. If so, nerve stimulation parameters can be adjusted for the patient.

For example, as can be seen in Figure 11, in the adaptive nerve stimulation system 100 according to an embodiment of the present invention, when a nerve signal is detected ((a) of Figure 11), the nerve signal is processed. Calculate the time interval (Width) between the first peak signal and the subsequent second peak signal in the neural firing signal ((b) of FIG. 11), and the time between the first peak signal and the subsequent second peak signal If the width is smaller than the predetermined second reference value, the nerve stimulation parameters for the patient are adjusted (Figure 11(c)).

In addition, in the nerve stimulation system 100 according to an embodiment of the present invention, as can be seen in FIG. 12, when the slew rate of the second peak signal is greater than a predetermined third reference value, Nerve stimulation parameters can be adjusted.

For example, as can be seen in Figure 12, in the adaptive nerve stimulation system 100 according to an embodiment of the present invention, when a nerve signal is detected ((a) of Figure 12), the nerve signal is processed. Calculate the slew rate of the second peak signal from the neural firing signal ((b) of FIG. 12), and when the slew rate of the second peak signal is greater than a predetermined third reference value Nerve stimulation parameters for the patient are adjusted (Figure 12(c)).

Furthermore, in the nerve stimulation system 100 according to an embodiment of the present invention, the amplitude of the first peak signal among the nerve firing signals, the time interval between the first peak signal and the subsequent second peak signal, and the If two or more of the slew rates of the two peak signals are outside the standard value, the nerve stimulation parameters can be adjusted using the sum of the plurality of nerve stimulation parameter adjustment values multiplied by each weight.

Additionally, in the nerve stimulation system 100 according to an embodiment of the present invention, nerve stimulation parameters for the patient can be adjusted by analyzing the frequency characteristics of the nerve signal along with analyzing the morphology of the nerve firing signal. there is.

More specifically, as can be seen in Figure 13, when a nerve signal is detected in the nerve stimulation system 100 according to an embodiment of the present invention ((a) of Figure 13), Fourier transform, etc. for the nerve signal is performed. By analyzing the frequency characteristics of the nerve signal through processing, nerve stimulation parameters for the patient can be adjusted (FIG. 13(b)).

Additionally, in the adaptive nerve stimulation system 100 according to an embodiment of the present invention, the nerve stimulation parameter adjustment unit 120 analyzes the morphology of the nerve firing signal and configures the nerve signal in advance. Nerve stimulation parameters for the patient can be adjusted by categorizing them into a plurality of predetermined patterns.

More specifically, as can be seen in Figure 14, when the nerve stimulation system 100 according to an embodiment of the present invention detects a nerve signal ((a) of Figure 14), the nerve signal is analyzed and a predetermined Classify into patterns (e.g., tonic patterns, random patterns, bursting patterns, etc. in Figure 14 (b)), calculate the ratio of each pattern constituting the neural signal, etc. The nerve stimulation parameters for the patient can be adjusted by determining whether the ratio of a specific pattern exceeds a predetermined standard value (Figure 14(c)).

Accordingly, the nerve stimulation system 100 according to an embodiment of the present invention considers the frequency characteristic analysis or pattern analysis of the nerve signal along with the morphology analysis of the nerve firing signal to determine the nerve response to the patient. By adjusting the stimulation parameters, it is possible to calculate more accurate nerve stimulation parameters.

Furthermore, in the nerve stimulation system 100 according to an embodiment of the present invention, when two or more of the morphology analysis, frequency characteristic analysis, and pattern analysis are considered together, a plurality of nerve stimulation parameters according to each analysis Nerve stimulation parameters can be adjusted using the sum of the adjustment values multiplied by the weights.

Accordingly, the nerve stimulation system 100 according to an embodiment of the present invention performs nerve stimulation on the patient according to the adjusted nerve stimulation parameters.

At this time, in the nerve stimulation system 100, a needle-shaped electrode 111a inserted into the nerve tissue is connected to the nerve tissue through a wire or the like to apply an electric signal to the nerve tissue to perform nerve stimulation or generate ultrasound. Thus, nerve stimulation can be performed by applying it to the patient's nervous tissue.

Furthermore, the nerve stimulation system 100 can perform nerve stimulation on the patient only when the nerve signal is determined to be abnormal, thereby preventing damage and necrosis of nerve tissue due to constant nerve stimulation. In addition, battery consumption can be reduced and the battery replacement cycle can be extended.

In addition, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve signal detection unit 111 and the nerve stimulation performance unit 122 may be connected to the same needle-shaped electrode 111a. The nerve signal detection unit 111 and the nerve stimulation performance unit 122 time divide the operation section, so that in the first section, the nerve signal detection section 111 detects the patient's nerve signal, and in the second section, the nerve signal detection unit 111 detects the patient's nerve signal. By allowing the nerve stimulation performing unit 122 to perform nerve stimulation for the patient, interference in mutual movements can be prevented and stable operation can be performed.

For a more specific example, the needle-shaped electrode 111a may be provided with a structure of a plurality of channels (e.g., a minimum of 4 channels to a maximum of 64 channels), where the plurality of channels are provided with a predetermined physical gap. It is possible for the user or control system to remotely set the location for optimal neural signal recording.

Furthermore, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve signal processing and stimulation control process using an adaptive stimulation control algorithm takes into account the clinical environment and a direction advantageous for treatment, and the needle-shaped electrode ( It is also possible to perform nerve stimulation on a patient by using 111a), by generating ultrasound in the nerve stimulation performing unit 122, or by using both together.

Furthermore, the nerve stimulation system 100 according to an embodiment of the present invention may further include a wireless setting unit (not shown) that allows manually setting nerve stimulation parameters for the patient.

At this time, the wireless setting unit (not shown) can manually set nerve stimulation parameters for the patient through wireless communication such as Bluetooth or Wi-Fi.

Accordingly, the nerve stimulation system 100 according to an embodiment of the present invention allows users, such as medical staff, to manually set the nerve stimulation parameters in consideration of the patient's condition, etc., to a setting value suitable for the patient without requiring reoperation. can be set.

Additionally, in the nerve stimulation system 100 according to an embodiment of the present invention, the nerve signal detection device 110 transmits the nerve signal to a user's terminal such as a smartphone, or transmits a message for performing nerve stimulation. Thus, predetermined processing can be performed or provided to the user to perform nerve stimulation using the portable nerve stimulation performing unit 122.

Additionally, Figure 15 shows a flowchart of a nerve stimulation method according to an embodiment of the present invention.

As can be seen in Figure 15, in the nerve stimulation method according to an embodiment of the present invention, the nerve stimulation device 120 uses nerve stimulation data for nerve stimulation for the patient calculated based on the patient's nerve signals. It may include a step of wirelessly receiving (S110) and applying a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain to perform nerve stimulation (S120).

The nerve stimulation method according to an embodiment of the present invention is similar in its operating principle and operation to the nerve stimulation system 100 described above and can be easily implemented and performed by a person skilled in the art. Therefore, a detailed description will be omitted and the nerve stimulation method described above will be omitted. Reference may be made to a series of descriptions of the stimulation system 100.

The above description is merely an illustrative explanation of the technical idea of the present invention, and those skilled in the art will be able to make various modifications, changes, and substitutions without departing from the essential characteristics of the present invention. It would be possible. Accordingly, the embodiments disclosed in the present invention and the attached drawings are not intended to limit the technical idea of the present invention, but are for illustrative purposes, and the scope of the technical idea of the present invention is not limited by these embodiments and the attached drawings. . The scope of protection of the present invention should be interpreted in accordance with the claims below, and all technical ideas within the equivalent scope should be construed as being included in the scope of rights of the present invention.

Claims

A nerve signal detection unit partially or fully inserted into the patient's brain to detect nerve signals,

a nerve signal detection device including a first wireless communication unit that wirelessly transmits nerve stimulation data for nerve stimulation of the patient calculated based on the nerve signal; and,

a second wireless communication unit that receives the nerve stimulation data from the nerve signal detection device;

A nerve stimulation device comprising a nerve stimulation performing unit that applies a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain to perform nerve stimulation;

A neurostimulation system comprising:
According to paragraph 1,

The nerve signal detection unit,

A needle-shaped electrode that senses nerve signals from the patient,

A nerve stimulation system comprising a nerve signal processing unit that calculates the nerve stimulation data based on the nerve signal sensed by the needle-shaped electrode.
According to paragraph 2,

The nerve signal processing unit adaptively calculates the nerve stimulation data by applying a first predetermined algorithm to the nerve signal,

A nerve stimulation system, wherein the nerve stimulation performing unit generates the nerve stimulation signal based on the nerve stimulation data and applies it to the patient's brain to perform nerve stimulation.
According to paragraph 3,

In the neural signal detection device,

A nerve stimulation system characterized in that the first algorithm is updated and applied with a second algorithm transmitted through the first wireless communication unit.
According to paragraph 1,

The nerve stimulation performing unit,

a nerve stimulation signal calculation unit adaptively calculating the nerve stimulation signal based on the nerve stimulation data;

A nerve stimulation system comprising a nerve stimulation application unit that applies the nerve stimulation signal to perform nerve stimulation to the patient's brain.
According to paragraph 1,

In the nerve stimulation performing unit,

A nerve stimulation system that generates ultrasound based on the nerve stimulation data and applies it to the patient's brain to perform nerve stimulation.
According to clause 6,

In the nerve stimulation performing unit,

A nerve stimulation system characterized in that a plurality of ultrasound generators are arranged to focus and apply the ultrasound to a specific area of the patient's brain.
According to clause 5,

A nerve stimulation system, wherein the nerve stimulation signal calculation unit adaptively calculates the nerve stimulation signal by applying a first predetermined algorithm to the nerve stimulation data.
According to clause 8,

In the nerve stimulator,

A nerve stimulation system characterized in that the first algorithm is updated and applied with a second algorithm transmitted through the second wireless communication unit.
According to paragraph 2,

In the nerve stimulation performing unit,

A nerve stimulation system that generates an electrical signal based on the nerve stimulation data and applies it to the patient's brain through the needle-shaped electrode to perform nerve stimulation.
According to clause 10,

The needle-shaped electrode is provided with a plurality of channels arranged at predetermined intervals,

Some channels among the plurality of channels are allocated as channels for sensing nerve signals,

A nerve stimulation system, characterized in that some channels among the plurality of channels are allocated as channels for performing nerve stimulation.
According to clause 10,

The needle-shaped electrode is a nerve stimulation system characterized in that it senses the nerve signal in a first section by time dividing the operation section, and performs nerve stimulation for the patient in a second section.
According to paragraph 1,

The nerve stimulation signal is,

A nerve stimulation system, characterized in that it is generated by analyzing the morphology of nerve firing signals among the nerve signals and adjusting nerve stimulation parameters for the patient.
A nerve stimulation device, wirelessly receiving nerve stimulation data for nerve stimulation for the patient calculated based on the patient's nerve signals; and

performing nerve stimulation by applying a nerve stimulation signal calculated based on the nerve stimulation data to the patient's brain;

A nerve stimulation method comprising: