WO2024085547A2 - Bloc de buse d'électrofilage comportant des moyens d'éjection de gaz et dispositif d'électrofilage comprenant ce bloc - Google Patents

Bloc de buse d'électrofilage comportant des moyens d'éjection de gaz et dispositif d'électrofilage comprenant ce bloc Download PDF

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Publication number
WO2024085547A2
WO2024085547A2 PCT/KR2023/015858 KR2023015858W WO2024085547A2 WO 2024085547 A2 WO2024085547 A2 WO 2024085547A2 KR 2023015858 W KR2023015858 W KR 2023015858W WO 2024085547 A2 WO2024085547 A2 WO 2024085547A2
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WIPO (PCT)
Prior art keywords
needle
nozzle
electrospinning
high voltage
air
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PCT/KR2023/015858
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English (en)
Korean (ko)
Inventor
박종수
임채근
황웅준
노용래
허웅
이천수
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박종수
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Publication of WO2024085547A2 publication Critical patent/WO2024085547A2/fr

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    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
    • D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
    • D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning

Definitions

  • the present invention relates to an electrospinning device, and more specifically, to an electrospinning device, comprising a gas ejection means for forming an air flow layer that surrounds the spinning filament discharged from a spinning nozzle at a distance from the discharge port and causes it to proceed in a straight line. It relates to a nozzle block for electrospinning and an electrospinning device equipped with this nozzle block.
  • the electrospinning process is a process of manufacturing nanofibers in an environment where an electric field is created by applying a direct current high voltage of thousands to tens of thousands of volts to a solution and connecting a ground or negative voltage to a collector.
  • a droplet of the charged spinning solution discharged from the spinning nozzle is formed in a cone shape at the nozzle tip, and the cone-shaped protrusion is stretched in the longitudinal direction toward the integrated plate, forming a charged filament.
  • the conical part of the droplet is called a Taylor cone, and the charged filament stretched in the longitudinal direction is called a jet.
  • the jet which is created by stretching from the protruding part of the Taylor cone, is manufactured into nanofibers with a very small diameter as the solvent is volatilized while going through a whipping mode that fluctuates rapidly from an arbitrary point above a critical high voltage. .
  • the higher the concentration of the spinning solution the smaller the size of the Taylor cone, the longer the length of the straight jet, and the fewer occurrences of the whipping mode.
  • Patent Document 1 Korean Registered Patent Publication No. 10-16011659 discloses a spinning nozzle equipped with a plurality of needles for spinning nanofibers, and a spinning nozzle with constant temperature and humidity air directly on the nanofibers spun between the spinning nozzles arranged in multiple rows. Disclosed is an electrospinning device equipped with a constant temperature and humidity unit that sprays. However, Patent Document 1 is intended to prevent temperature and humidity from changing depending on the location by spraying air with constant temperature and humidity on the nanofiber web accumulating in the collector, and cannot prevent fine droplets generated from the discharged spinning solution.
  • Patent Document 2 (Korean Patent Registration No. 10-1440448) includes a housing with an exhaust hole formed at one end through which nitrogen gas supplied from the outside is sprayed to the outside through the exhaust hole; It includes a nozzle unit, one end of which is inserted into the discharge hole to spray the drug to the outside, and the other end of which is supplied with electricity, wherein the discharge hole is disposed around one end of the nozzle unit, and the drug passes through one end of the nozzle unit.
  • an electrospinning nozzle module in which a drug is sprayed and coated on an object to which nitrogen gas is also sprayed through one end of the nozzle portion when spraying.
  • the configuration of arranging the nitrogen gas discharge hole around one end of the nozzle portion of Patent Document 2 is to prevent the drug from being exposed to general air and causing infection when the drug is sprayed and coated.
  • Patent Document 3 (Republic of Korea Patent Publication No. 10-1478184) discloses a body having a solution receiving space for receiving a supplied solution; A plurality of solution spray nozzles installed on the body along the longitudinal direction to communicate with the solution receiving space; and an electrospinning nozzle pack including a gas injection nozzle disposed surrounding the solution injection nozzle so that it penetrates the center. Patent Document 3 also has a problem in that the gas injection nozzle is arranged to surround the solution injection nozzle, so the inlet of the injection nozzle is blocked due to solidification of the solution discharged from the solution injection nozzle.
  • Patent Document 2 a solution spray nozzle, which is a solution discharge port, is disposed at the center of the nozzle, and a cap having a center hole larger than the outer diameter of the solution spray nozzle is disposed around the nozzle.
  • the spinning solution is atomized by blowing air or gas into the space formed between the cap and the cap.
  • the first technical task of the present invention is to suppress the generation of fine droplets by rapidly converting discharged droplets into spinning filaments by increasing the spinning speed by vertically jetting air currents around the spinning filament flying in the air layer. .
  • the second technical problem of the present invention is to vertically eject an air stream to the periphery of the spinning filament flying in the air layer without affecting the tip of the spinning nozzle.
  • the electrospinning nozzle block according to the first aspect of the present invention for achieving the above-described technical problem includes a nozzle body including an internal space accommodating a spinning solution transferred from a solution storage tank and injected, and a plurality of solution distribution ports; An electrospinning nozzle including an airflow ejection means, a nozzle adapter for attaching and detachably coupling the electrospinning nozzle to the nozzle body, and a spinning solution accommodated in the inner space of the nozzle body for high-voltage electricity from a high-voltage generator.
  • the electrospinning nozzle includes: an internal nozzle body into which a spinning solution, which is a first fluid, is injected; an internal needle unit connected to the internal nozzle unit body and having an internal needle in the form of a hollow tube that is a discharge port of the first fluid; An external nozzle body into which air, a second fluid, is injected; and a gas ejection means coupled to the end of the external nozzle body and generating a flow of air, which is the second fluid, flowing straight while surrounding the spinning filament discharged from the internal needle at a distance from the discharge hole;
  • the gas ejection means includes a central hole penetrating the internal needle and a plurality of gas ejection ports arranged radially surrounding the central hole at a constant distance apart;
  • the high-voltage application means includes high-conductivity, high-voltage application needles corresponding one-to-one to the electrospinning nozzle; It includes a high-voltage body that fixes and arranges the high
  • the gas jets are at least two in a plurality of circumferential areas consisting of at least one circular line around the central hole. It is characterized by being arranged at regular intervals and consisting of a plurality of air holes that discharge the air, which is the second fluid, to the outside.
  • Another third aspect of the present invention is that in the electrospinning nozzle block of the second aspect, the gas jet is spaced apart from the central hole by a radius r 1 and is located in a first circumferential area, which is the first circular line surrounding the central hole.
  • a first gas outlet in which at least two or more air holes are arranged, and a second in which at least two or more air holes are arranged in a second circumferential area, which is a second circular line spaced apart from the central hole by a radius r 2 and surrounding the central hole. It includes a gas outlet, and the radius r 2 of the second circumferential region is larger than the radius r 1 of the first circumferential region.
  • Another fourth aspect of the present invention is the electrospinning nozzle block of the third aspect, wherein a plurality of n-th circumferential regions surround the second circumferential region outside the second circumferential region (where n is 3 or more). place more natural numbers); At least two air holes are disposed in the nth circumferential region.
  • Another fifth aspect of the present invention is the electrospinning nozzle block of the fourth aspect, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region and the nth circumferential region. It is characterized by
  • the gas ejection means includes a side fastening part coupled to an extended end of the external nozzle body, the central hole, and the central hole. It includes a cover portion formed with a plurality of gas discharge ports disposed surrounding the hole; It is characterized as an air cap in which a residence space for air, which is the second fluid, is formed by the side fastening portion and the cover portion.
  • Another seventh aspect of the present invention in the electrospinning nozzle block of the sixth aspect, further includes a guide needle in the form of a hollow tube for guiding the high voltage application needle to stably enter the hole;
  • the guide needle is disposed between the high voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high voltage application needle.
  • Another eighth aspect of the present invention is that in the electrospinning nozzle block of the sixth aspect, the high voltage application needle is disposed on the same side inside the inner needle of the electrospinning nozzle or inside the solution storage space of the inner nozzle body. It is characterized in that it is arranged coaxially.
  • Another ninth aspect of the present invention is that the electrospinning nozzle block of the sixth aspect further includes a linear reciprocating mechanism for reciprocating the high voltage application means up and down in the longitudinal direction of the nozzle. .
  • Another tenth aspect of the present invention is characterized in that, in the electrospinning nozzle block of the sixth aspect, the arrangement spacing of the electrospinning nozzles attached to the nozzle body is 20 mm to 70 mm.
  • Another 11th aspect of the present invention is the electrospinning nozzle block of the 6th aspect, wherein the high voltage body is composed of a circular rod or square rod made of metal that is energized inside an insulating cylindrical pipe or square pipe, and this metal rod It is characterized in that the high voltage application needles are combined one-to-one.
  • the high voltage application needle is a hollow metal needle or a metal wire.
  • the electrospinning nozzle block includes an internal space accommodating a spinning solution transferred and injected from a solution storage tank, a nozzle body including a plurality of solution distribution ports, and an airflow ejection means.
  • the electrospinning nozzle includes: an internal nozzle body into which a first fluid is injected; an internal needle unit connected to the internal nozzle unit body and having an internal needle in the form of a hollow tube that is a discharge port of the first fluid; an external nozzle body into which the second fluid is injected; an external needle unit connected to the external nozzle body and having an external needle in the form of a hollow tube, which is a discharge port of the second fluid, and arranged to coaxially surround the internal needle; an external needle position adjusting unit that adjusts the central axis position of the external needle; A gas inlet for injecting air, which is a gas; And a gas ejection means that generates a straight air flow while surrounding the spinning filament discharged from the double needle, which is coupled to the end of the outer needle position control unit and consists of an outer needle coaxially surrounding the inner needle, at a distance away from the discharge port.
  • the gas ejection means includes a central hole penetrating the double needle and a plurality of gas ejection ports arranged radially surrounding the central hole at a constant distance apart;
  • the high-voltage application means includes high-conductivity, high-voltage application needles corresponding one-to-one to the electrospinning nozzle; It includes a high-voltage body that fixes and arranges the high-voltage application needles in the width direction;
  • the nozzle body is characterized in that a plurality of holes for passing the high voltage application needles are formed opposite to where the electrospinning nozzle is coupled.
  • the external needle position adjusting part is disposed between the external needle part and the gas ejection means and has a cylindrical cylinder shape to form a gas flow path. It is characterized in that it includes a position adjusting unit body and a plurality of screw pins installed on a portion of the position adjusting unit body to adjust the central axis of the external needle.
  • the gas inlet is formed at one end of the position adjusting unit body, and air injected through the gas inlet is directed to the gas ejection means. It is characterized by discharge.
  • Another 16th aspect of the present invention is the electrospinning nozzle block of the 15th aspect, wherein the plurality of screw pins are spaced apart from each other at a predetermined angle around a portion of the position adjusting unit body and extend around the external needle. It is characterized in that it is arranged to surround the.
  • the inner diameter of the external needle is configured to be 5 ⁇ m to 1,000 ⁇ m larger than the outer diameter of the internal needle, and the internal needle and the external needle The distance between central axes is characterized by being within 0.1 mm.
  • Another 18th aspect of the present invention is the electrospinning nozzle block of the 16th aspect, wherein the gas jet is at least 2 in a plurality of circumferential areas consisting of at least one circular line around the central hole. It is characterized in that it consists of a plurality of air holes arranged at regular intervals to discharge the air, which is the second fluid, to the outside.
  • Another 19th aspect of the present invention is the electrospinning nozzle block of the 18th aspect, wherein the gas jet is spaced apart from the central hole by a radius r 1 and is located in a first circumferential area, which is the first circular line surrounding the central hole.
  • a first gas outlet in which at least two or more air holes are arranged, and a second in which at least two or more air holes are arranged in a second circumferential area, which is a second circular line spaced apart from the central hole by a radius r 2 and surrounding the central hole. It includes a gas outlet, and the radius r 2 of the second circumferential region is larger than the radius r 1 of the first circumferential region.
  • Another 20th aspect of the present invention is the electrospinning nozzle block of the 19th aspect, wherein a plurality of n-th circumferential regions surround the second circumferential region outside the second circumferential region (where n is 3 or more). place more natural numbers); At least two air holes are disposed in the nth circumferential region.
  • Another 21st aspect of the present invention is the electrospinning nozzle block of the 20th aspect, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region and the nth circumferential region. It is characterized by
  • Another 22nd aspect of the present invention is the electrospinning nozzle block of the 21st aspect, wherein the gas ejection means includes a side fastening part coupled to the extending end of the external needle position adjusting part, the center hole and the center It includes a cover portion formed with a plurality of gas discharge ports disposed surrounding the hole; It is characterized as an air cap in which a space for the air to remain inside is formed by the side fastening part and the cover part.
  • Another 23rd aspect of the present invention is that, in the electrospinning nozzle block of the 22nd aspect, it further includes a guide needle in the form of a hollow tube for guiding the high voltage application needle to stably enter the hole;
  • the guide needle is disposed between the high voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high voltage application needle.
  • Another 24th aspect of the present invention is that in the electrospinning nozzle block of the 22nd aspect, the high voltage application needle is disposed on the same side inside the inner needle of the electrospinning nozzle or inside the solution storage space of the inner nozzle body. It is characterized in that it is arranged coaxially.
  • the electrospinning nozzle block includes an internal space accommodating a spinning solution transferred and injected from a solution storage tank, a nozzle body including a plurality of solution distribution ports, and an airflow ejection means.
  • the electrospinning nozzle includes: an internal nozzle body including a first fluid injection port through which a first fluid is injected; an internal needle unit connected to the internal nozzle unit body and having an internal needle in the form of a hollow tube that is a discharge port of the first fluid; an external nozzle body including a second fluid inlet through which air, a second fluid, is injected;
  • a pneumatic control unit body including a needle shaft for controlling and blocking the flow of the first fluid transferred to the internal needle unit, and a needle shaft sealing unit for preventing the first fluid from flowing back and leaking into the upper part of the needle shaft; and a gas ejection means coupled to the end of the external nozzle body and generating a flow of air, which is the second fluid, flowing straight while surrounding the spinning filament discharged from the internal needle at a distance from the discharge hole;
  • the gas ejection means includes a central hole penetrating the internal needle and a plurality of gas ejection ports arranged radially surrounding the central hole at a constant distance apart;
  • the pneumatic control unit body further includes an air inlet for injecting air into the needle shaft;
  • the needle shaft includes a spring wound around the needle shaft and having elastic restoring force, a tapered blocking portion formed at the end of the needle shaft to block a fluid passage toward the inner needle portion to block the flow of the first fluid, and It is connected to the tapered blocking part and includes a shaft needle with a sharp end that penetrates the inner needle and protrudes through its distal end.
  • Another twenty-seventh aspect of the present invention is the electrospinning nozzle block of the twenty-sixth aspect, wherein the gas jet is at least two in a plurality of circumferential areas consisting of at least one circular line around the central hole. It is characterized in that it consists of a plurality of air holes arranged at regular intervals to discharge the air, which is the second fluid, to the outside.
  • Another 28th aspect of the present invention is the electrospinning nozzle block of the 27th aspect, wherein the gas jet is spaced apart from the center hole by a radius r 1 and is located in a first circumferential area, which is the first circular line surrounding the center hole.
  • a first gas outlet in which at least two or more air holes are arranged, and a second in which at least two or more air holes are arranged in a second circumferential area, which is a second circular line spaced apart from the central hole by a radius r 2 and surrounding the central hole. It includes a gas outlet, and the radius r 2 of the second circumferential region is larger than the radius r 1 of the first circumferential region.
  • Another twenty-ninth aspect of the present invention is the electrospinning nozzle block of the twenty-eighth aspect, wherein a plurality of n-th circumferential regions (where n is 3 or more) surround the second circumferential region on the outside of the second circumferential region. place more natural numbers); At least two air holes are disposed in the nth circumferential region.
  • Another 30th aspect of the present invention is the electrospinning nozzle block of the 29th aspect, wherein six air holes are arranged at an angle of 60° to each other in the first circumferential region, the second circumferential region and the nth circumferential region. It is characterized by
  • the gas ejection means includes a side fastening part coupled to an extended end of the external nozzle body, the center hole, and the center It includes a cover portion formed with a plurality of gas discharge ports disposed surrounding the hole; It is characterized as an air cap in which a residence space for air, which is the second fluid, is formed by the side fastening portion and the cover portion.
  • Another 32nd aspect of the present invention is that, in the electrospinning nozzle block of the 31st aspect, it further includes a guide needle in the form of a hollow tube for guiding the high voltage application needle to stably enter the hole;
  • the guide needle is disposed between the high voltage body and the nozzle body, and the inner diameter of the guide needle is larger than the diameter of the high voltage application needle.
  • Another 33rd aspect of the present invention is that in the electrospinning nozzle block of the 31st aspect, the high voltage application needle is disposed on the same side inside the inner needle of the electrospinning nozzle or inside the solution storage space of the inner nozzle body. It is characterized in that it is arranged coaxially.
  • the electrospinning device includes an unwinder unit serving as an unwinding unit for unwinding a roll on which a base material for laminating nanofibers by spinning a spinning solution is wound, and nanofibers are laminated.
  • a winder unit serving as a winding unit for winding the base material
  • At least one nozzle block array formed by connecting at least one electrospinning nozzle block selected from the first to thirty-third aspects in the width direction of the substrate, and the at least one nozzle block array while transporting the substrate a collector for laminating nanofibers radiated from; a solution storage tank for storing the spinning solution; a solution transfer mechanism for transferring the spinning solution from the solution reservoir to the spinning nozzle of the modular electrospinning nozzle block; and a high-voltage power supply for applying high direct current voltage to the spinning solution.
  • Another thirty-fifth aspect of the present invention is the electrospinning device of the thirty-fourth aspect, comprising: a robot drive unit for reciprocating the nozzle block array in the width direction of the substrate; a radiation distance control unit that moves the nozzle block array up and down to adjust the distance between the collector and the tip of the radiation needle; It is characterized by further comprising a collection guide portion disposed on the left and right sides of the nozzle block array in the direction in which the substrate is transported and stacking the radiated nanofibers into a limited area of the collector.
  • Another thirty-sixth aspect of the present invention is the electrospinning device of the thirty-fifth aspect, comprising a hot air generator for producing fine nanofibers by volatilizing a solvent from a large amount of spinning filaments spun from spinning needles on the nozzle block array; ; A humidity control device for controlling the solvent volatilization rate by controlling the internal humidity of the electrospinning device; And it is characterized by further comprising a lamination device for controlling the bonding state of the nanofibers configured to the substrate.
  • an electrospinning nozzle block and an electrospinning device including an electrospinning nozzle provided with a porous gas jet at a certain distance away from the center hole through which the spinning needle passes.
  • nanofibers can be manufactured more efficiently without generating fine droplets from discharged droplets, and a uniform nanofiber web can be manufactured.
  • the production rate of nanofibers can be increased by increasing the volatilization rate of the solvent and increasing the discharge amount of the solution.
  • FIG. 1 is a cross-sectional view of an electrospinning nozzle according to a first preferred embodiment of the present invention.
  • Figure 2 is a transverse cross-sectional view taken along line A-A of the gas ejection means of the electrospinning nozzle of Figure 1.
  • Figure 3 is a longitudinal cross-sectional view of the gas ejection means of Figure 2 taken along line B-B.
  • Figure 4 is a cross-sectional view of an electrospinning nozzle according to another second embodiment of the present invention.
  • Figure 5 is a cross-sectional view of an electrospinning nozzle according to another third embodiment of the present invention.
  • Figure 6 is a schematic perspective view showing the configuration of an electrospinning nozzle block to which an electrospinning nozzle according to the present invention is applied.
  • Figure 7 is a perspective view of a downward roll-to-roll electrospinning device in which a plurality of electrospinning nozzle blocks of Figure 6 are arranged in succession.
  • Figure 1 is a cross-sectional view showing the configuration of an electrospinning nozzle equipped with a gas ejection means according to a first embodiment of the present invention.
  • the electrospinning nozzle 100 includes an internal nozzle body 101 into which a spinning solution, which is a first fluid, is injected, and an external nozzle body 102 into which air, a second fluid, is injected. ) and an internal needle unit 103 having a hollow needle 103a, which is the discharge port of the first fluid, and a spinning solution coupled to the end of the external nozzle unit body 102 and discharged from the hollow needle 103a.
  • a gas ejection means 104 that generates a flow of air, which is the second fluid, flowing straight while surrounding the charged filament at a distance from the discharge port, and a high voltage application means connected to the internal nozzle body 101. Includes (106).
  • the internal nozzle body 101 has a first fluid inlet (101a), which is an inlet through which the spinning solution, which is the first fluid, is injected, a solution storage space (101b) where the spinning solution flows and stays, and the spinning solution is supplied through the internal needle ( It consists of a tapered outlet (101c) that delivers to 103a).
  • the internal needle unit 103 is detachably coupled to the internal nozzle unit body 101 through an internal needle unit fastening cap 105.
  • the outer surface of the inner nozzle body 101 may be provided with threads for fixing to a specific external fixing part (not shown).
  • a syringe or male fitting having an outlet of a Luer lock structure in the shape of a two-line screw is coupled to the first fluid inlet (101a) of the internal nozzle body (101), or is used for fastening tubing. Fittings may be configured in combination.
  • the outlet 101c of the internal nozzle body 101 is formed in a Luer taper shape so that it comes into contact with the socket portion of the internal needle unit 103 and is tightly coupled.
  • the solution storage space 101b of the internal nozzle body 101 may be used as a flow path through which the spinning solution is transferred or may be used as a storage space where the solution temporarily resides.
  • connection standard of the Luer taper of the outlet 101c of the internal nozzle body 101 is ISO 594 standards ⁇ ISO 594-1:1986"Conical fittings with a 6%(Luer) taper for syringes, needles and certain other medical equipment. ".[1](https:/www.iso.org/standard/4693.html) ⁇ .
  • the material of the internal nozzle body 101 is preferably a metal that can conduct electricity, such as stainless steel (SUS), aluminum, copper plated with nickel or chrome, or new stock plated with nickel or chrome. Meanwhile, when the spinning solution, which is the first fluid, is a biopolymer solution containing cells, the material of the internal nozzle body 101 is a fluorine-based polymer such as Teflon, PEEK (polyetheretherketone), carbide, or quartz. Non-metallic materials may be used.
  • a high voltage application means 106 for applying a direct current high voltage of tens to tens of thousands of volts is connected to the inner nozzle body 101. Therefore, when a high voltage is applied to the internal nozzle body 101, the spinning solution discharged from the tip of the internal needle 103a is charged by the high voltage.
  • the internal needle unit 103 which is detachably coupled to the internal nozzle unit body 101 through the internal needle unit fastening cap 105, has an internal hollow tube shape for discharging the spinning solution to the outside. It is provided with a needle (103a). This inner needle (103a) is coupled to the inner needle portion (103) by placing a hub or sleeve.
  • the sleeve may be a hollow tube or may be made of a hollow screw with threads on the outside.
  • the sleeve is made of a polymer system with ductility and elasticity, it becomes easier to replace the hollow needle (103a) from the inner needle portion (103).
  • the hollow tube-shaped sleeve is made of a flexible material with chemical resistance such as fluorinated ethylene propylene (FEP), perfluoroalkoxyalkane (PFA), and polytetrafluoroethylene (PTFE). It is desirable.
  • the sleeve may be made of a conductive polymer material containing carbon or a metal component.
  • the inner diameter of the hollow tube-shaped sleeve is preferably approximately the same as the outer diameter of the inner needle (103a) or smaller than the outer diameter of the inner needle (103a) to ensure excellent adhesion to the inner needle (103a). That is, the hollow tube-shaped sleeve preferably has an inner diameter of 0.05 to 4 mm and an outer diameter of 1 to 5 mm.
  • the sleeve may be copper-based or a non-metallic sleeve containing copper may be used. More preferably, the material of the sleeve may be a new cast, a nickel-plated cast, a non-ferrous metal containing copper, an aluminum base, or a moldable polymer such as SUS metal or PEEK.
  • the internal needle 103a preferably has an inner diameter of 0.005 mm to 2 mm, an outer diameter of 0.02 mm to 3 mm, and a length of 2 mm to 200 mm.
  • the material of the internal needle 103a is preferably stainless steel (SUS), silica, quartz, superboundary, fluorine, or PEEK-coated SUS.
  • the tip of the internal needle 103a may have a blunt end or a sharp end.
  • the corner angle of the blunt smooth end may be a 90-degree angled tip, a chamfered tip with rounded edges, or a tapered tip with a gradually tapered end.
  • a cap 105 for fastening the internal needle unit When coupling the internal needle unit 103 to the internal nozzle unit body 101, a cap 105 for fastening the internal needle unit is used.
  • the cap 105 for fastening the inner needle portion has a semicircular groove structure in which the hub of the inner needle portion 103 is seated, or has a luer lock structure.
  • the inner needle part fastening cap 105 is configured with a semicircular groove structure, the inner needle part 103 is seated in the groove of the inner needle part fastening cap 105, and then the cap 105 is installed. When turned, the socket portion of the hub of the inner needle portion 103 is pushed up to the top of the taper and comes into contact with it. On the other hand, if the inner needle part fastening cap 105 has a luer lock structure with a double-threaded screw thread on the inside, when the hub of the inner needle part 103 is turned, it is pushed up and coupled to the top of the tapered part. .
  • the external nozzle unit body 102 surrounds the internal needle unit 103 and at least a portion of the internal nozzle unit body 101 and is coupled to the internal nozzle unit body 101.
  • This external nozzle body 102 includes a second fluid inlet 102a for injecting air, which is a second fluid, and a seating space for seating the internal needle unit 103.
  • the second fluid inlet 102a is formed by attaching a female fitting or a tubing fitting to the side surface.
  • the female fitting material is preferably made of an insulating material so as not to be affected by an electric field even when a high voltage is applied.
  • the gas ejection means 104 is fastened to the lower end of the external nozzle body 102. That is, a fastening tubing 102b extending in the longitudinal direction of the nozzle is formed at the lower end of the external nozzle body 102.
  • This fastening tubing (102b) preferably has an outer diameter smaller than that of the outer nozzle body (102).
  • threads may be formed on the outer surface of the fastening tubing (102b) for attachment and detachment from the gas ejection means (104).
  • the gas ejection means 104 is fastened to the fastening tubing 102b of the external nozzle body 102 to cover the seating space of the external nozzle body 102 to form a space in which air, which is the second fluid, stays. It is a type of air cover or air cap for this purpose.
  • the gas ejection means 104 is composed of a side fastening part 104b that is screwed to the fastening tubing 102b and a cover part 104a that covers the seating space and forms an air retention space.
  • the cover portion 104a is formed with a central hole 114 penetrating the internal needle 103a and a plurality of gas discharge ports 115 surrounding the central hole 114.
  • FIG. 2 is a transverse cross-sectional view of the gas ejection means 104 according to the first embodiment of the present invention taken along the line A-A
  • FIG. 3 is a longitudinal cross-sectional view of the gas ejection means 104 of FIG. 2 taken along the line B-B.
  • the gas ejection means 104 has a central hole 114 penetrating the internal needle 103a, and several to dozens of circular lines arranged to surround the central hole 114 with at least two circular lines. It consists of a type of air cap including a gas outlet 115.
  • the gas outlet 115 is an air hole that discharges air, which is the second fluid injected from the second fluid inlet 102a, to the outside.
  • several layers of air flow layers 116 are formed around the inner needle 103a penetrating through the central hole 114, extending in parallel with the inner needle 103a.
  • the gas outlet 115 may be arranged at regular intervals or at random in a plurality of circumferential areas consisting of at least one circular line around the central hole 114.
  • the first circular area 111 which is the first circular line spaced apart from the central hole 114 by a radius r 1 and surrounding the central hole 114, has six first gas jets ( 115a) are arranged to have an angle of 60° to each other.
  • the second circumferential area 112 which is the second circular line spaced apart from the central hole 114 by a radius r 2 and surrounding the central hole 114, six second gas jets 115b are formed at an angle of 60° to each other.
  • the radius r 2 of the second circumferential region 112 is larger than the radius r 1 of the first circumferential region 111 . That is, the radius r 1 is 2 to 10 mm, more preferably 3 to 5 mm, and the radius r 2 is 4 to 20 mm, more preferably 4 to 10 mm.
  • the gas outlet 115 may be configured as a circular or rectangular hole, but is preferably configured as a circular hole. At this time, when the gas outlet 115 is composed of a circular hole, the diameter of the circular hole is preferably 0.1 mm to 2 mm.
  • the gas ejection port 115 may be formed by press-fitting a hollow needle with an inner diameter of 0.1 mm to 1 mm into the cover portion 104a of the gas ejection means 104 instead of a circular hole.
  • first and second gas jets 115a and 115b are arranged to surround the central hole 114 with two circular lines.
  • the gas ejection means 104 of the present invention is not necessarily limited to this arrangement or configuration.
  • a plurality of nth circumferential regions (where n is a natural number of 3 or more) surrounding the second circumferential region 112 may be further disposed outside the second circumferential region 112 .
  • more than 6 gas outlets and fewer than 6 gas outlets are arranged in the first circumferential area 111, the second circumferential area 112, and the nth circumferential area (where n is a natural number of 3 or more). can do.
  • the plurality of gas jets 115 disposed in one circumferential area may be arranged to have a constant angle (for example, 60°) to each other, or may be arranged randomly without angle rules.
  • the diameter of the central hole 114a is approximately the same size or slightly larger than the outer diameter of the hollow needle 103a passing through the central hole 114.
  • the diameter of the central hole 114 is preferably 0.001 mm to 0.5 mm larger than the outer diameter of the hollow needle 103a. More preferably, the diameter of the central hole 114 is set to be larger than the outer diameter of the hollow needle 103a by about 0.001 mm to 0.1 mm so that there is no gap between the central hole 114 and the hollow needle 103a, thereby forming a gap. It is best to prevent the second fluid, air, from leaking.
  • the thickness (h 1 ) of the cover portion 104a which is the bottom surface of the air cap as the gas ejection means 104, is preferably 0.1 mm to 5 mm. More preferably, the thickness (h 1 ) of the cover portion 104a is 0.5 mm to 2 mm. At this time, if the thickness (h 1 ) of the cover portion 104a exceeds 5 mm, it is difficult to machine a small diameter hole.
  • an O-ring (O -ring) can be installed.
  • the material of the O-ring may be fluorine-based, Viton, olefin-based of ethylene-propylene, or silicon-based.
  • the hollow needle 103a protrudes through the central hole 114 of the air cap 104, and the protrusion length at this time is preferably 1 to 10 mm.
  • the spinning solution which is the first fluid
  • the spinning solution is injected through the first fluid injection port 101a, and the spinning solution is discharged through the tip of the internal needle 103a.
  • air which is the second fluid
  • the air is ejected through a plurality of gas ejection ports 115 provided in the air cap, which is the gas ejection means 104.
  • the spinning solution discharged from the internal needle 103a is generated as a filament jet of a certain length through a conical Taylor cone, and then goes through a whipping mode in which the filament jet is rapidly whipped at a specific location, and the solvent is volatilized and flows into the collecting area. Laminated with nanofibers.
  • the filament jet flies within a certain area of the air layer, and the air flow ejected from the gas outlet 115 and moving straight forward pushes the filament jet toward the collecting unit within a range spaced a certain distance apart. Because it forms an airflow layer, it can suppress the filament jet from spreading or dispersing excessively to the outside in whipping mode.
  • the straight air flow is concentrated on the charged filament in the whipping mode section. Due to this, the charged filaments by the spinning solution are stably formed and concentrated and laminated within the desired lamination area of the integration portion.
  • Figure 4 is a cross-sectional view showing the configuration of an electrospinning nozzle according to another second embodiment of the present invention.
  • the electrospinning nozzle 300 according to the second embodiment of the present invention in the electrospinning nozzle 100 of the first embodiment, has an external needle disposed while coaxially surrounding the internal needle and a central axis position of the external needle. It is characterized in that it further includes an external needle position adjustment part for adjusting. That is, the electrospinning nozzle 300 according to the present embodiment further includes an external needle portion 304 and an external needle position adjusting portion 306 in addition to the configuration of the electrospinning nozzle 100 of the first embodiment. Except for this, it is substantially the same as the electrospinning nozzle 100 of the first embodiment. Therefore, a detailed description of the configuration of the electrospinning nozzle 300 of this embodiment that is the same as that of the electrospinning nozzle 100 of the first embodiment will be omitted.
  • the electrospinning nozzle 300 includes an internal nozzle body 301 into which the first fluid is injected, an external nozzle body 302 into which the second fluid is injected, and the It is connected to the internal nozzle body 301 and has an internal needle 303a in the form of a hollow tube, which is the discharge port of the first fluid, and is connected to the external nozzle body 302,
  • An external needle portion 304 arranged to coaxially surround the internal needle 303a and having an external needle 304c in the form of a hollow tube, which is the discharge port of the second fluid, and the central axis position of the external needle 304c Gas is ejected around a double needle consisting of an external needle position control unit 306 that adjusts and an external needle 304c that is coupled to the external needle position control unit 306 and coaxially surrounds the internal needle 303a. It includes a gas ejection means 307 for this purpose and a high voltage application means 308 connected to the internal nozzle body 301.
  • the second fluid injected into the external needle part 304 is injected into the second fluid inlet 302a, and gas (eg, air) is injected into the gas inlet 306d.
  • gas eg, air
  • the external needle portion 304 includes a holder 304a into which an external needle 304c equipped with a sleeve 304b is press-fitted.
  • a hole or thread for press-fitting the sleeve 304b is formed in the holder 304a of the external needle portion 304.
  • the hole of the holder 304a is preferably machined to have a diameter somewhat smaller than the outer diameter of the sleeve 304b to prevent liquid leakage after the sleeve 304b of the external needle 304c is pressed in.
  • the entrance to the hole of the holder 304a be slightly grooved (R-machined) to facilitate insertion of the sleeve 304b.
  • R-machined slightly grooved
  • M2 to M5 preferably M3
  • the external needle position adjusting unit 306 includes a cylindrical position adjusting unit body 306a disposed between the external needle unit 304 and the gas ejection means 307 to form a gas flow path, and the position adjusting unit. It is installed on a portion of the body 306a and includes a plurality of screw pins 306b for adjusting the central axis of the external needle 304c.
  • a gas inlet (306d) is coupled to one end of the position adjusting unit body (306a), and the gas (air) injected through the gas inlet (306d) is supplied to a plurality of gases formed in the gas ejection means (307) through the gas flow path. It is discharged through the outlet (307a).
  • a fastening tubing 306c is formed at the lower end of the position adjusting unit body 306a and is coupled to the side fastening portion of the gas ejection means 307. That is, a fastening tubing 306c extending in the longitudinal direction of the nozzle is formed at the lower end of the external adjusting body 360a.
  • This fastening tubing (306c) preferably has an outer diameter smaller than that of the position adjusting unit body (306a).
  • threads may be formed on the outer surface of the fastening tubing 306c to enable attachment and detachment from the gas ejection means 307.
  • the plurality of screw pins (306b) are arranged to surround a portion of the position adjusting unit body (306a) and surround the outer needle (304c) while being spaced apart from each other at a certain angle (e.g., 60 degrees apart). do. At this time, the plurality of screw pins 306b may be arranged in a line or zigzag up and down while surrounding the outer needle 304c.
  • At least one screw pin (306b), preferably six, is arranged at 60-degree intervals to adjust the central axis of the external needle (304c).
  • the central position of the outer needle (304c) is adjusted to match the central position of the inner needle (303a) disposed inside the coaxial axis.
  • the diameter of the screw pin 306b is preferably 0.5 mm to 5 mm.
  • the end of the screw pin 306b is preferably sharp or U-shaped. If the inner needle (303a) and the outer needle (304c) are arranged coaxially with each other, the distance between the central axes of the inner needle (303a) and the outer needle (304c) is preferably adjusted to within 0.1 mm.
  • the outer diameter of the position control body 306a is preferably 5 mm to 50 mm, and the inner diameter is 2 mm to 45 mm.
  • the position control body 306a may be made of any one of SUS metal, aluminum, brass, PEEK, acetal, and nylon.
  • the position adjusting unit body 306a is made of a conductive metal material, spinning stability can be achieved at the tip of the internal needle 303a by applying high voltage to the external needle position adjusting unit 306.
  • the inner diameter of the external needle 304c is 5 ⁇ m to 1,000 ⁇ m larger than the outer diameter of the internal needle 303a.
  • the inner needle 303a and the outer needle 304c are 17G-23G [17G (OD: 1.47mm, ID: 1.07mm)], 23G (OD: 0.63 mm, ID:0.33mm)], 17G-25G[17G(OD:1.47mm, ID:1.07mm), 25G(OD:0.50mm, ID:0.25mm)], 18G-25G[18G(OD:1.27mm) , ID:0.85mm), 25G(OD:0.50mm, ID:0.25mm), 21G-27G[21G(OD:0.80mm, ID:0.50mm), 27G(OD:0.40mm, ID:0.20mm)] and 22G-30G [22G(OD:0.70mm, ID:0.40mm), 30G(OD:0.30mm, ID
  • the gas ejection means 307 including a central hole 307d through which the outer needle 304c coaxially (or non-coaxially) surrounds the inner needle 303a and a plurality of gas ejection ports 307a is provided by the position adjusting unit. It is coupled to the fastening tubing 360c formed at the lower end of the body 306a.
  • the center hole (307d) is sealed by installing a thin silicon plate (307d) or an O-ring and tightening the hollow screw (307b).
  • the length at which the external needle 304c protrudes outward through the central hole 307d is preferably 1 to 10 mm from the bottom of the gas ejection means 307.
  • the gas ejection means 307 according to this embodiment is completely identical in structure and function to the gas ejection means 104 shown in FIGS. 2 and 3 of the first embodiment.
  • the first spinning solution which is the first fluid
  • the spinning solution is discharged through the tip of the internal needle 303a.
  • a second spinning solution which is a second fluid
  • the air is ejected through a plurality of gas ejection ports 307a provided in the air cap, which is the gas ejection means 307.
  • the first spinning solution discharged from the internal needle 303a and the second spinning solution discharged from the external needle 304c are generated as a filament jet of a certain length through a conical Taylor cone, and then the filament jet rapidly fluctuates at a specific position.
  • the solvent is volatilized and deposited as nanofibers in the integrated area.
  • the filament jet flies within a certain area of the air layer, and the air flow ejected from the gas outlet 307a and moving straight forward pushes the filament jet toward the collecting unit within a range spaced a certain distance away from the filament jet. Because it forms an airflow layer, it can suppress the filament jet from spreading or dispersing excessively to the outside in whipping mode. Due to this, the spinning filaments are laminated into a core-cell structured nanofiber web within the desired lamination area of the integration portion.
  • Figure 5 is a cross-sectional view showing the configuration of an electrospinning nozzle 400 according to another third embodiment of the present invention.
  • the electrospinning nozzle 400 according to the third embodiment of the present invention in the electrospinning nozzle 100 of the first embodiment, includes a needle shaft 411 capable of controlling and blocking the flow of the spinning solution during the electrospinning process. It is characterized in that it further includes. That is, the electrospinning nozzle 400 according to the present embodiment has the electrospinning nozzle 100 of the first embodiment except that it additionally includes a needle shaft 411. It is substantially the same as the nozzle 100. Accordingly, a detailed description of the configuration of the electrospinning nozzle 400 of this embodiment that is the same as that of the electrospinning nozzle 100 of the first embodiment will be omitted.
  • the electrospinning nozzle 400 includes an internal nozzle body 401 including a first fluid injection port 401a through which the first fluid is injected, and the internal nozzle body ( 401), and includes an internal needle portion 403 having an internal needle 403b in the form of a hollow tube, which is the discharge port of the first fluid, and a second fluid inlet 402a, through which gas, which is the second fluid, is injected.
  • an external nozzle body 402 an air inlet 410a through which air is injected, a needle shaft 411 for controlling and blocking the flow of the first fluid transferred to the internal needle part 403, and a needle shaft ( 411), a pneumatic control unit body 410 including a needle shaft sealing part 412 to prevent the first fluid from flowing back and leaking into the upper part, a central hole 404a through which the internal needle 403b passes, and A gas ejection means 404 including a plurality of gas ejection ports 404b for ejecting gas (air), which is a second fluid, to the outside around the central hole 404a, and connected to the internal nozzle body 101. It includes high voltage applying means (406).
  • the electrospinning nozzle 400 of this embodiment is connected to the external nozzle body 302 as in the second embodiment, and has an external needle in the form of a hollow tube arranged to coaxially surround the internal needle 403b. It may further include an external needle position adjustment part including an external needle unit provided with a plurality of screw pins for adjusting the central axis position of the external needle.
  • the needle shaft 411 has a tapered blocking portion 411a that blocks the fluid passage toward the inner needle portion 403 to block the flow of the first fluid, and penetrates the inner needle 403b and protrudes through its distal end. It includes a shaft needle 411b with a sharp end.
  • the needle shaft 411 is normally maintained in an upwardly raised state by the elastic restoring force of the spring 413 wound around the shaft. Accordingly, the fluid passage leading to the internal needle part 403 is opened (ON state) and sends the first fluid to the internal needle part 403. And, when air is injected through the air injection port 410a, the spring 413 of the needle shaft 411 is compressed by pneumatic pressure, and the tapered blocking portion 411a at the tip of the needle shaft 411 is exposed to the first fluid. At the same time as blocking the fluid passage, the shaft needle (411b) protrudes through the inner needle (403b) to block the hollow of the inner needle (403b).
  • the spinning solution which is the first fluid
  • the spinning solution is injected through the first fluid injection port 401a, and the spinning solution is discharged through the tip of the internal needle 403b.
  • the air is ejected through a plurality of gas ejection ports 404b provided in the air cap, which is the gas ejection means 404.
  • the spinning solution discharged from the internal needle 403b is generated as a filament jet of a certain length through a conical Taylor cone, and then goes through a whipping mode in which the filament jet is rapidly whipped at a specific position, and the solvent is volatilized and the collecting part is laminated with nanofibers.
  • the first fluid injected through the first injection port 401a is transferred to the inner needle part 403, it flows back to the upper part of the inner needle part 403 and leaks through the sealing part 412 of the needle shaft 411. ) is blocked.
  • the filament jet flies within a certain area of the air layer, and the air flow ejected from the gas outlet 404b and moving straight forward pushes the filament jet toward the collecting unit within a range spaced at a certain distance. This prevents the filament jet from spreading or dispersing excessively to the outside in whipping mode. Because of this, the spinning filaments can be concentrated and laminated within the desired lamination area of the integration portion.
  • the spring 413 of the needle shaft 411 is compressed by pneumatic pressure, and the tapered blocking portion 411a at the tip of the needle shaft 411 is connected to the first fluid.
  • the passage is blocked, and at the same time, the shaft needle 411b penetrates the inner needle 403b and blocks the passage of the inner needle 403b, thereby blocking the flow of the spinning solution, which is the first fluid, and the electrospinning process is stopped.
  • the air injected into the air inlet 410a is blocked and air is injected into the second fluid inlet 402a.
  • the spring 413 of the needle shaft 411 returns to its original position by elastic restoring force, and the fluid passage of the internal needle portion 403 is converted to an open state. and the electrospinning process is resumed.
  • the needle shaft 411 can simply ON/OFF control the flow of the spinning solution injected into the first fluid inlet 401a.
  • the electrospinning nozzle 400 of this embodiment when it further includes an external needle coaxially surrounding the internal needle 403b, another spinning solution is injected into the second fluid inlet 402a, and the gas outlet 404b ) may further include a separate gas inlet for injecting air to be ejected through.
  • Figure 6 is a schematic perspective view showing the configuration of an electrospinning nozzle block to which an electrospinning nozzle according to the present invention is applied.
  • the electrospinning nozzle block 200 of a preferred embodiment according to the present invention includes an internal space for receiving a spinning solution transferred and injected from a solution storage tank (not shown), and a plurality of solution distribution ports.
  • a nozzle body 230 an electrospinning nozzle 210 selected from the first, second, and third embodiments, and the electrospinning nozzle 210 to the nozzle body 230.
  • a nozzle adapter 220 that is detachably coupled to the high voltage generator 250 and a high voltage application means 240 for applying high voltage electricity from the high voltage generator 250 to the spinning solution contained in the inner space of the nozzle body 230. Includes.
  • the nozzle body 230 is a cylindrical pipe or square pipe with an internal space for accommodating the spinning solution flowing from a solution storage tank (not shown). Additionally, the nozzle body 230 may be composed of a square container composed of an upper body and a lower body that can be separated from and combined with each other.
  • the internal space of the nozzle body 230 is used to temporarily retain the spinning solution flowing from the solution storage tank while delivering it to the electrospinning nozzle 210, or to temporarily store the spinning solution when the electrospinning process is temporarily stopped. It is used as space.
  • the height of the internal space may be 1 mm to 30 mm, more preferably 3 mm to 10 mm when used as a residence space, and 20 mm to 500 mm when used as a storage space.
  • the nozzle body 230 is preferably made of an insulating material such as PEEK or fluorine-based polymer (Teflon).
  • the electrospinning nozzle 210 is detachably coupled to the nozzle body 230 through the nozzle adapter 220.
  • the electrospinning nozzle 210 can be pushed up to the top of the nozzle adapter 220 and then tightened by turning it 45 to 360 degrees using a thin screw or a double-threaded screw, or it can be fixed by pushing it up and press-fitting it.
  • the nozzle adapter 220 may be equipped with an ON/OFF valve that can block and control the flow of the solution to prevent the spinning solution from leaking from the nozzle body 230 after the electrospinning nozzle 210 is separated. there is.
  • the arrangement spacing (distance between neighboring electrospinning nozzles) of the electrospinning nozzles 210 attached to the nozzle body 230 is 20 mm to 70 mm. More preferably, when the electrospinning nozzles 210 are arranged at high density to mass-produce nanofibers, the spacing between the electrospinning nozzles 210 is preferably 10 mm to 40 mm.
  • the material of the nozzle adapter 220 is preferably fluorine-based polyetheretherketone (PEEK), polytetrafluoroethylene (PTFE), or metal-based stainless steel (SUS).
  • PEEK fluorine-based polyetheretherketone
  • PTFE polytetrafluoroethylene
  • SUS metal-based stainless steel
  • the high voltage application means 240 is a means for transmitting the high voltage from the high voltage generator 250 to the spinning solution of the nozzle body 230, and the high voltage application needles 241 correspond one to one to the electrospinning nozzle 210. ) and a high voltage body 242 that fixes and arranges the high voltage application needles 241 at a constant width in the width direction (direction perpendicular to the nozzle direction).
  • These high-voltage application needles 241 are made of metal with excellent electrical conductivity.
  • a plurality of holes 233 for passing the high voltage application needles 241 are formed opposite to where the electrospinning nozzle 210 is coupled.
  • the high voltage application needles 241 penetrate the hole 233 and enter the inner space of the nozzle body 230, and charge the spinning solution remaining or stored in the inner space with high voltage.
  • a guide needle in the form of a hollow tube may be further included to guide the high voltage application needle 241 so that it can stably enter the hole 233.
  • This guide needle is disposed between the high voltage body 242 and the nozzle body 230 so that the high voltage application needles 241 can accurately enter the hole 233 of the nozzle body 230.
  • Guide (241) Therefore, the inner diameter of the guide needle must be at least larger than the diameter (or outer diameter) of the high voltage application needles 241.
  • the high-voltage body 242 may be composed of a circular rod or square rod (hereinafter abbreviated as 'metal rod') made of SUS metal that conducts electricity inside an insulating cylindrical pipe or square pipe made of PEEK or PTFE fluorine.
  • the high voltage application needles 241 are coupled one to one to this metal rod.
  • the high voltage body 242 is composed of a cylindrical pipe or a square pipe made of metal that can conduct electricity, and a plurality of high voltage application needles 241 may be press-fitted into the high voltage body 242.
  • an adapter can be installed, and the high-voltage application needle 241 can be configured as a hub-type energizing needle so that it can be attached to or detached from the adapter.
  • the high voltage application needle 241 is made of a conductive material with high electrical conductivity, such as a hollow metal needle or a metal wire.
  • the high-voltage application needles 241 are disposed ipsilaterally inside the inner needles 103a, 303a, and 403b of the electrospinning nozzle 210 or coaxially within the solution storage space 101b of the inner nozzle body 101, 301, and 401. It can be placed as .
  • the tip of the high voltage application needle 241 is preferably located within 0 mm to 50 mm from the tip of the internal needles 103a, 303a, and 403b.
  • the high voltage applying means 240 can reciprocate up and down in the nozzle direction by the linear reciprocating mechanism 245.
  • FIG. 7 is a perspective view of a downward roll-to-roll electrospinning device 500 in which a plurality of electrospinning nozzle blocks 200 of FIG. 6 are sequentially arranged.
  • the top-down roll-to-roll electrospinning device 500 uses the electrospinning nozzle block 200 4 of FIG. 6 with a unit length of 500 mm to produce a wide nanofiber web with a width of at least 1,000 mm. It can be configured by continuously arranging the pieces in the width direction of the substrate (arrow A).
  • the top-down roll-to-roll electrospinning device 500 includes an unwinder unit 501 as an unwinding unit that unwinds a roll on which a substrate for laminating nanofibers is wound by spinning a spinning solution. ), a winder portion 502 as a winding portion for winding a substrate on which nanofibers are laminated, and a plurality of (e.g., four) electrospinning nozzle blocks 200 of FIG. 6 of the substrate. At least one or more (e.g., three) nozzle block arrays 506 formed by continuously connecting in the width direction (direction of arrow A), and from the at least one or more nozzle block arrays 506 while transferring the substrate. It includes a collector 503 for laminating the spun nanofibers and a solution storage tank (not shown) for storing the spinning solution.
  • an unwinder unit 501 as an unwinding unit that unwinds a roll on which a substrate for laminating nanofibers is wound by spinning a spinning solution.
  • the downward roll-to-roll electrospinning device 500 of the present invention includes a plunger for pushing the solution in the solution storage tank and a solution transfer pump for operating the plunger to precisely transfer the spinning solution to the spinning nozzle.
  • a solution transfer pump for operating the plunger to precisely transfer the spinning solution to the spinning nozzle.
  • a high-voltage power supply 507 that applies a charge of (+) or (-) polarity, a robot drive unit 508 for reciprocating the nozzle block array 506 in the width direction of the substrate, and the collector 503 ) and a radiation distance control unit 509 that moves the nozzle block array 506 up and down to adjust the distance between the tips of the radiation needles, and a left side of the nozzle block array 506 in the direction in which the substrate is transferred.
  • the collection guide unit controls the nanofibers spun from both ends of the spinning nozzle so that they are not pushed outward and spread out, so that they are integrated into the limited inner area of the collector 503.
  • a high voltage of the same polarity as the high voltage applied to the spinning solution may be applied to the collection guide unit, or a pneumatic air current may be used.
  • the top-down roll-to-roll electrospinning device 400 of the present invention includes a hot air generator for making fine nanofibers by volatilizing a solvent from a large amount of spinning filaments spun from the spinning needles of the nozzle block array 506, and an electric It may further include a humidity control device for controlling the solvent volatilization rate by adjusting the internal humidity of the spinning device 500 and a lamination device for controlling the bonding state of the nanofibers formed on the substrate.
  • the downward roll-to-roll electrospinning device 500 of the present invention monitors in real time the solidified or blocked state of the spinning solution formed at the tip of the spinning needle or the liquid droplet state of the Taylor cone formed at the tip of the spinning needle to create a video or image. It may further include a video camera capable of recording. This video camera is located at the bottom of the side of the nozzle block array 506 and moves back and forth to check the state of the tip of the radiation needle in real time or take images.
  • the solution storage tank and the solution transfer pump according to the present invention may be configured to be combined with each other to push the solution in the solution storage tank.
  • the solution storage tank preferably has a double structure in which the inside is made of SUS metal, and the outside of the SUS metal is coated with fluorine-based polymer, polyethylene (PE), or polypropylene (PP) as an exterior material.
  • the solution storage tank may be made of insulating materials such as polypropylene (PP), polyethylene (PE), polyether ether ketone (PEEK), MC nylon, and acetal with excellent voltage resistance.
  • the capacity of the syringe-type solution storage tank is preferably 10ml to 3,000ml. Meanwhile, it is desirable to install a Teflon cover on the tip of the plunger or a Teflon seal such as an omni seal to prevent the solution from leaking out of the back of the plunger when pushing the solution with the plunger.
  • the solution transfer pump consists of a motor unit, a screw connected to the axis of the motor, a pusher fastened to the screw to push the plunger located inside the reservoir, a guide rod connecting the plunger and the pusher, and a linear motion (hereinafter referred to as , LM) It consists of a guide part and a support part for fastening and fixing the solution storage tank.
  • the lead of the screw is 0.5 to 2 mm. Preferably it is 1mm.
  • the minimum movement speed of the pusher according to the screw rotation is preferably 1 ⁇ m/hour to 100 ⁇ m/hour, and the maximum speed is 1cm/minute to 20cm/minute.
  • the plunger moves forward inside the barrel by operating a motor from the outside and extrudes the solution.
  • the plunger of the solution transfer pump can push the solution using air pressure without external motor operation.
  • two solution transfer pumps can be placed in parallel and a three-way valve can be configured to transfer the solution.
  • the flow direction of the valve opens from the first solution pump to the spinning nozzle, and the second solution pump remains closed.
  • the direction of the valve is configured such that the first transfer pump is closed and the spinning nozzle in the second transfer pump is switched to an open state. At this time, the completely exhausted solution transfer pump is filled separately.
  • nanofibers In the spinning process, it is desirable to produce nanofibers with a solution discharge rate of 0.5 ⁇ l/min to 1,000 ⁇ l/min per spinning needle.
  • the preferred discharge amount of the solution is 5 ⁇ l/min to 300 ⁇ l/min.
  • the intensity of the applied high voltage is 0.01 kV/cm to 10 kV/cm based on the distance (cm) between the tip of the spinning needle 111b and the collector 503.
  • a more desirable high voltage intensity is 0.5kV/cm to 25kV/cm.
  • the collector 503 which is a nanofiber integrated part, can rotate together when the substrate moves, and is composed of a plurality of rod rolls, multiple wire rolls, or conveyor-type rolls whose surfaces are electrically conductive, and the rolls are grounded or connected to the polarity of the charged solution. Direct current power with opposite polarity may be applied. At this time, the intensity of the applied voltage, which has a polarity opposite to that of the solution, is 1kV to 20kV.
  • the transfer speed of the substrate is preferably 10 cm per minute to 50 m per minute.
  • the hot air coming from the hot air generator is set within the wind speed of 0.1 m/sec to 10 m/sec and the temperature range of 20°C to 150°C.
  • the hot air temperature is preferably 30°C to 80°C.
  • a nanofiber web with micropores can be manufactured by using an electrospinning device using the electrospinning nozzle block according to the present invention, and this nanofiber web can be used as a membrane for waterproofing and moisture permeability, a filter medium for filtration of ultrafine dust particles, and a cell culture material. It is used as a scaffold, a drug-carrying patch, a sensor material with a high specific surface area, and a flexible electronic material.

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Abstract

La présente invention concerne un bloc de buse d'électrofilage comprenant : un espace interne pour loger une solution de filage transférée et injectée à partir d'un réservoir de stockage de solution ; un corps de buse comprenant une pluralité d'orifices de distribution de solution ; une buse d'électrofilage comprenant un moyen d'éjection de flux d'air ; un adaptateur de buse pour coupler de manière amovible la buse d'électrofilage au corps de buse ; et un moyen d'application de haute tension pour appliquer de l'électricité haute tension à partir d'un générateur de haute tension à la solution de filage logée dans l'espace interne du corps de buse.
PCT/KR2023/015858 2022-10-20 2023-10-13 Bloc de buse d'électrofilage comportant des moyens d'éjection de gaz et dispositif d'électrofilage comprenant ce bloc WO2024085547A2 (fr)

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KR101478184B1 (ko) 2012-09-21 2014-12-31 (주)우리나노필 전기방사 노즐 팩 및 이를 포함하는 전기방사 시스템
KR101440448B1 (ko) 2013-02-20 2014-09-17 전북대학교산학협력단 약물 코팅용 전기방사 노즐모듈
KR101601169B1 (ko) 2013-07-02 2016-03-08 주식회사 아모그린텍 전기 방사장치

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