WO2024084471A1 - Saflufenacil microemulsion composition, method for the preparation thereof and use of same - Google Patents

Saflufenacil microemulsion composition, method for the preparation thereof and use of same Download PDF

Info

Publication number
WO2024084471A1
WO2024084471A1 PCT/IB2023/060736 IB2023060736W WO2024084471A1 WO 2024084471 A1 WO2024084471 A1 WO 2024084471A1 IB 2023060736 W IB2023060736 W IB 2023060736W WO 2024084471 A1 WO2024084471 A1 WO 2024084471A1
Authority
WO
WIPO (PCT)
Prior art keywords
mixtures
derivatives
oxide
composition
salts
Prior art date
Application number
PCT/IB2023/060736
Other languages
French (fr)
Portuguese (pt)
Inventor
Natália GONÇALVES
Rafaela Cristina FEITOSA CORSI
Felipe Augusto SOARES DA SILVA
Joseph Alberto HERNÁNDEZ NAVARRO
João Paulo ALEIXO
Original Assignee
Dva Agro Gmbh
Dva Brasil Produtos Agrícolas Ltda.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BR102022021378A external-priority patent/BR102022021378A2/en
Priority claimed from BR102023020981-5A external-priority patent/BR102023020981A2/en
Application filed by Dva Agro Gmbh, Dva Brasil Produtos Agrícolas Ltda. filed Critical Dva Agro Gmbh
Publication of WO2024084471A1 publication Critical patent/WO2024084471A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines

Definitions

  • the present invention relates to a new microemulsion composition (ME) comprising saflufenacil. Additionally, the present invention relates to a process for preparing the ME composition, as well as its use as a herbicide. Finally, the present invention relates to a process for controlling the growth of undesirable plants. BACKGROUND OF THE INVENTION [002] Agribusiness represents an important sector for the economy of several countries, such as Brazil and the United States. However, this area faces some problems related to its production, especially due to the resistance created to the most common pesticides and the difficulty in obtaining new stable formulations.
  • Saflufenacil is an example of a herbicide usually used in crops resistant to glyphosate and/or ALS-inhibiting herbicides. [006] Saflufenacil belongs to agrochemicals with high efficiency, but low solubility in liquid media, including water, making it a challenge to obtain stable formulations that contain this active ingredient.
  • WO2021038439 presents a concentrated solution (SL) formulation of saflufenacil and an organic base.
  • the formulations of WO2021038439 that contain only saflufenacil as the active ingredient have a high load of surfactants, making this product more expensive, which may make it commercially unviable.
  • SL formulations are commonly recognized for having low spreading and poor resistance to rain in the field.
  • WO2017037210 presents a composition of microcapsules comprising saflufenacil.
  • MEs microemulsions
  • BR 11 2020 017457 2 presents a herbicidal composition comprising a herbicidally active compound comprising a pyrimidinedione-based compound, and an efficacy enhancer, such as, for example, castor oil-based surfactants, ethoxylates or polyoxyethylene sorbitan monolaurate.
  • an efficacy enhancer such as, for example, castor oil-based surfactants, ethoxylates or polyoxyethylene sorbitan monolaurate.
  • said efficacy enhancers are not suitable for the preparation of ME formulations comprising saflufenacil, as they cause crystallization of the active ingredient.
  • the present invention reduces the contamination of soil, groundwater, rivers, among other environments that came into contact with said agricultural pesticide, since said invention reduces the necessary amount of agricultural pesticides in the field, as it increases efficiency of the active ingredients of the formulation.
  • the present invention relates to a microemulsion composition comprising saflufenacil, its salts or its N-oxides, and nitrogenous non-ionic surfactants.
  • the present invention refers to a process for preparing said composition, which is capable of obtaining a stable formulation, without the formation of crystals or phase separation.
  • the present invention relates to a process for controlling agricultural pests, such as Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp.
  • agricultural pests such as Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L.
  • Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., and Xanthium strumarium L. including biotypes resistant to triazine and ALS, and other agricultural pests, especially in soybean crops, vegetables, fruits, citrus, legumes, vegetables, broad beans, tubers, crucifers, vegetables, nuts, trees, herbaceous plants, herbs, roses, ornamental plants, pastures, or any other crop affected by such undesirable plants.
  • the present invention relates to the use of said composition as a herbicide.
  • FIG. 1 microemulsion composition comprising fully translucent saflufenacil.
  • FIG. 2 Chromatogram of the primary saflufenacil repeat 1 solution.
  • Fig. 3 Chromatogram of the saflufenacil repeat 2 primary solution.
  • Fig. 4 Chromatogram of the saflufenacil repeat 3 primary solution.
  • the present invention relates to a microemulsion composition comprising saflufenacil, its salts or its N-oxides, and nitrogenous non-ionic surfactants.
  • the present invention relates to a microemulsion composition
  • a microemulsion composition comprising (i) saflufenacil, its salts or its N-oxides, (ii) at least one organic polar solvent, (iii) at least one nitrogenous non-ionic surfactant and (iv) at least one amphoteric co-surfactant.
  • Said saflufenacil is present in a range of 15% to 35% of the total weight of the composition.
  • Said at least one organic polar solvent is selected from aldehydes, alkylnitriles, alkanes, amides, amines, ketones, esters, nitriles, aromatic substituted hydrocarbons, aliphatic substituted hydrocarbons, cycloaliphatic substituted hydrocarbons, halogenated hydrocarbons, nitroalkanes, sulfoxides, sulfones , their derivatives or their mixtures.
  • said at least one organic polar solvent is selected from formylmorpholine, N-formylmorpholine, dimethylacetamide, N,N-dimethylacetamide, dimethylformamide, N,N′-dimethylpropyleneourea, formamide, methylformamide, N-methylformamide, N,N -dimethylformamide, tetramethylurea, N-vinylacetamide, octanamide, N,N-dimethyl + decanamide, N,N-dimethyl, 2-pyrrolidone, N-methylpyrrolidone, N-vinylpyrrolidone, dimethylsulfoxide, diethylsulfoxide, propylene carbonate, 4-ethyl-1 ,3-dioxolan-2-one, 4-(methoxymethyl)-1,3-dioxolan-2-one, derivatives thereof or mixtures thereof.
  • Said at least one nitrogenous non-ionic surfactant is selected from oxidized amines, alkylamides, amine ethoxylated fatty alcohols, amine ethoxylates, polymers of propylene oxide and amine ethylene oxide, imidazoline, ethoxylated fatty acid amides, mixtures thereof or derivatives thereof.
  • said nitrogenous non-ionic surfactants are selected from tallow amine 10 EO, laurylamine N-oxide, cocamide DEA, ethoxylated laurylamine, ethoxylated thalamus oil amine, lauramide DEA, ethoxylated lauryl amine, soy amine ethoxylated, ethoxylated oleyl amine, ethoxylated stearic amine, dimethyldodecylamine oxide, oleyldi(2-hydroxyethyl)amine oxide, dimethyltetradecylamine oxide, di(2-hydroxyethyl)tetradecylamine oxide, dimethylhexadecylamine oxide, behenamine oxide, oxide cocamine, decyltetradecylamine oxide, dihydroxyethyl C12-C15 alkoxypropylamine oxide, dihydroxyethyl cocamine oxide, dihydroxyethyl la
  • Said at least one amphoteric co-surfactant is selected from betaines, amphoacetate, sulfobetaine, imidazoline, propianate, acetate, quaternary ammonium, its derivatives and mixtures.
  • said at least one amphoteric co-surfactant is selected from cocoamidobetaine, lauramidopropyl betaine, coco-betaine, cocoamfoacetate acid, lauramfoacetate acid, sulfobetaine and imidazoline, their derivatives or mixtures thereof.
  • This compound is present in a range of 1% to 15% of the total weight of the composition.
  • water must be present in the formulation in a concentration between 0.1% to 25% of the total weight of the composition. The presence of water not only avoids the excessive use of other solvents that are more aggressive to the environment, it also reduces the production costs of the formulation, in addition to allowing the formation of the microemulsion.
  • the formulation of the present invention can be used in conjunction with other additional agricultural pesticides.
  • Said additional pesticides are selected from among herbicides belonging to classes of acetyl CoA carboxylase (ACCase) inhibitors, HPPD inhibitors, glutamate synthase inhibitors, acetolactate synthase (ALS) inhibitors, EPSP synthase inhibitors, synthesis inhibitors of lipids, auxin transport inhibitors, very long chain fatty acid inhibitors, carotenoid biosynthesis inhibitors, microtubule inhibitors, photosystem inhibitors, PPO inhibitors, mixtures or derivatives thereof.
  • ACCase acetyl CoA carboxylase
  • HPPD acetyl CoA carboxylase
  • glutamate synthase inhibitors glutamate synthase inhibitors
  • ALS acetolactate synthase
  • EPSP synthase inhibitors synthesis inhibitors of lipids
  • auxin transport inhibitors very long chain fatty acid inhibitors
  • the ACCase inhibitor is selected from aloxidime, clethodime, cialofop, clodinafop, diclofop, fenoxaprop, fluazifop, fenoxaprop-P, haloxyfop, metamifop, propaquizafop, quizalofop, sethoxydime, tepraloxidime, tralkoxidime and pinoxaden, their derivatives, salts and N-oxides, or mixtures thereof.
  • the ALS inhibitor is selected from amidosulfuron, azimsulfuron, bensulfurone, bencarbazone, bispiribaque, chlorimurone, cloransulam, cyclosulfamurone, ethoxysulfuron, diclosulam, florasulam, flumetsulam, flazasulfuron, flucarbazone, flucetosulfuron, flupirsulfuron, foramsulfuron, imazosulfuron, ipfencarbazone, mesosulfuron, metazosulfuron, nicosulfuron, orthosulfamurone, oxasulfuron, primisulfuron, propyrisulfuron, pyrazosulfuron, rimsulfuron, sulfomeclomazoturone, sulfometurone-methyl, sulfosulfuron, trifloxysulfuron, chlorsulfur
  • the EPSP synthase inhibitor is selected from glyphosate, sulfosate, their derivatives, salts and N-oxides, or mixtures thereof.
  • the auxin transport inhibitor is selected from diflufenzopyr and naptalam, their derivatives, salts and N-oxides, or mixtures thereof.
  • the glutamate synthase inhibitor is selected from glufosinate and bialaphos, their derivatives, salts and N-oxides, or mixtures thereof.
  • the HPPD inhibitor is selected from benzobicyclone, benzofenape, biciclopyrone, phenquinotrione, isoxachlorotol, isoxaflutole, mesotrione, sulcotrione, pyrasulfotol, pyrazolinate, pyrazoxifene, tefuryltrione, tembotrione, tolpiralate and topramezone, their derivatives, salts and N-oxides, or mixtures thereof.
  • the lipid synthesis inhibitor is selected from butylate, cycloate, eptc, eptam, thiobencarb, triallate, their derivatives, salts and N-oxides, or mixtures thereof.
  • the carotenoid biosynthesis inhibitor is selected from beflubutamide, diflufenican, fluridone, fluorochloridone, flutamone picolinaphene, norflurazone, their derivatives, salts and N-oxides, or mixtures thereof.
  • the long-chain fatty acid inhibitor is selected from alachlor, acetochlor, anilophos butachlor, cafenstrola, dimethenamid, dimethenamid-P, fenoxasulfone, fentrazamide, flufenacet, indanophane, metazachlor, metolachlor, mefenacet, naproanilide, pretylachlor, pyroxasulfone, propachlor , S-metolachlor, and tenylchlor, their derivatives, salts and N-oxides, or mixtures thereof.
  • the photosystem inhibitor is selected from ioxynyl, ioxynyl octanoate, bentazone, pyridate, bromoxynyl, bromoxynyl octanoate, chlorotolurone, dimefurone, diuron, linurone, fluometurone, isoproturone, isourone, tebuthiurone, benzthiazurone, metabenzthiazurone, propanyl, metobromurone, methoxurone, monolinuron, sidurone, simazine, atrazine, propazine, cyanazine, ametrine, simethrin, dimethethrin, promethrin, terbumetone, terbuthylazine, terbutrin, triethazine, hexazinone, metamitrone, metribuzin, amicarbazone, bromacil, lenacil, terbaccil, chlor
  • the amount of additional pesticide in the composition or to be applied in the field will depend on the type of pesticide to be used and its manufacturer. Said quantities are known in the prior art, especially because the pesticides mentioned here are widely used in the field of this invention. Each additional state-of-the-art pesticide is accompanied by a leaflet, which will indicate the appropriate dosage for application in the field. That being said, the quantities mentioned here are not intended to limit the present invention, but only to better define the subject matter of protection.
  • the composition of the present invention also comprises other adjuvants or compounds capable of improving a specific property of the composition such as, for example, its solubility or pesticidal effect.
  • Said adjuvants or other compounds capable of improving a specific property of the composition comprise phosphoric acid ethoxylated alkyl ester compounds, methyl esters or fatty acid methyl esters, metal complexes, complexes of inorganic or organic compounds, aromatic hydrocarbons, fatty acids unsaturated or saturated, one or more basic compounds, one or more acids, salts, macro or micronutrients, diluents, organic or inorganic solids, fillers, preservative agents, antioxidant agents, humectants, dispersing agents, solid carriers, suspending or anti-sedimentation agents, absorption or adsorption aids, adhesive agents, disintegrating agents, stabilizers, antifreezes, anticrystallizers, polymers or copolymers, mineral, vegetable, organosilicon oils, soluble or insoluble in water, organic or inorganic substances, or mixtures thereof, and any other components present in state-of-the-art formulations widely used in the field of application of the invention.
  • said composition comprises (v) at least one anticrystallizing agent and (vi) at least one preservative agent.
  • Said at least one anticrystallizing agent is selected from copolymers, polymers, glycols, phosphoric esters, fatty acids and their salts, soluble salts, saccharides, polysaccharides, fatty acid esters, amines, silicones, polyoxyethylene esters, chelating agents , temponating agents, their derivatives and mixtures thereof.
  • said at least one anticrystallizing agent is selected from block copolymer of polyalkylene oxide, polyethylene glycol, polyvinylpyrrolidone, ethanol, propylene glycol, derivatives thereof and mixtures thereof.
  • Said at least one preservative agent is selected from phenolics, aromatic organic compounds, thiazolines and isothiazolinones, parabens, formaldehydes, alcohols, diols, acids, oxidants, pyridine derivatives, organic acids, quaternary ammonium salts, aldehydes, their derivatives and their mixtures.
  • said at least one preservative agent is selected from di-tert-butyl methyl phenol (BHT), benzimidazole, methylisothiazolinone, methylchloroisothiazolinone, methylparaben, propylparaben, thiabendazole, phenoxyethanol, benzisothiazolinone, chloromethylisothiazolinone, bronopol (2-bromo- 2-nitropropane-1,3-diol), benzoic acid, sorbic acid and their salts, their derivatives and mixtures thereof.
  • BHT di-tert-butyl methyl phenol
  • benzimidazole benzimidazole
  • methylisothiazolinone methylchloroisothiazolinone
  • methylparaben methylparaben
  • propylparaben propylparaben
  • thiabendazole phenoxyethanol
  • benzisothiazolinone chloromethyliso
  • the composition now described may be in the form of “ready mix” or “in can” formulations.
  • the present invention refers to a process for preparing the composition as described herein, which comprises the steps of: a) adding at least one organic polar solvent; b) add at least one nitrogenous non-ionic surfactant; c) adding at least one amphoteric co-surfactant; d) add saflufenacil; in which the compounds from steps a) to d) remain in constant agitation.
  • the process comprises the steps of: a) adding at least one organic polar solvent; b) add at least one non-ionic surfactant nitrogenous; c) adding at least one amphoteric co-surfactant; d) adding at least one preservative agent; e) add saflufenacil; and f) adding at least one anticrystallizing agent, whereby the compounds from steps a) to f) remain in constant agitation.
  • the agitation of this mixture must be maintained at between 250 and 1000 rpm, preferably between 700 and 800 rpm, in order to keep the mixture homogenized throughout the process.
  • step a) at least two organic polar solvents are added, in which one of the organic polar solvents is selected from an amine or aldehyde, and the other polar organic solvent is selected from amides, in a proportion to each other of 1:1 to 1:2.5, respectively.
  • the at least one anticrystallizing agent must be previously melted.
  • water can be added to the mixture.
  • the pH of the formulation must be between 5.5 and 8.0, preferably between 6.0 and 8.0, since in different pH ranges saflufenacil can degrade.
  • weak acids or bases must be added, depending on the final pH of the formulation, such as citric acid, hydrochloric acid, sulfuric acid, sodium hydroxide, ammonium hydroxide, potassium hydroxide, or any other weak acid or base known in the art. [0066] The preparation process must be carried out at temperatures between 5oC and 40oC.
  • the present invention relates to a process for controlling the growth of undesirable plants, such as Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea , Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., and X
  • the process of controlling undesirable plants comprises the application of the microemulsion (ME) composition comprising saflufenacil of this invention, especially in crops of soybeans, vegetables, fruits, citrus, legumes, vegetables, broad beans, tubers, crucifers, vegetables, nuts , trees, herbs, herbaceous plants, roses, ornamental plants, pastures, preferably, crops are selected from onion, pineapple, peanuts, asparagus, sugar beet, turnip, canola, turnip, Chinese cabbage, Camellia sinensis, safflower, walnut pecan, lemon, orange, coffee, cucumber, grass, carrot, oil palm, strawberry, cotton, sunflower, rubber tree, barley, hops, potato, sweet potato, common walnut, lentil, flax, tomato, apple, cassava, alfalfa, banana, tobacco, olive tree, rice, lima beans, broad beans, beans, Norway pine, pine, pea, apricot, sweet cherry, sour cherry, almond, plum, peach, pear, currant,
  • crops
  • Controlling the growth of undesirable plants includes preventing, killing, reducing or retarding their growth.
  • the formulations of the present invention can be applied by the pre- or post-emergence method, and pre-planting incorporated depending on the undesirable plant to be eliminated. Particularly, saflufenacil is commonly used for post-treatment.
  • the application rates of the combination may vary depending on several factors, which are widely known in the area of application of this invention, such as, for example, the nature of the soil, the method of application (post-emergence; foliar treatment; of seeds; application in the seed furrow; etc.), the crop plant, the undesirable agricultural pests to be controlled, the climatic conditions at the time of application and other factors.
  • the application rate of saflufenacil can be from 15 to 500, preferably from 30 to 150 g/ha.
  • Field application can be carried out by spraying the combination, dusting, dripping, irrigation, or injection into the soil, depending on the structure that the applicator presents, as well as the form of the combination.
  • the present invention relates to the use of this composition as a herbicidal composition, to eliminate or reduce the growth of undesirable plants.
  • the examples now described are not intended to limit the scope of this invention, but are intended to prove that additional experiments needed to be developed to achieve the correct production process of the composition now claimed.
  • EXAMPLE 1 [0076] To prepare a first ME composition, formylmorpholine >99% and propylene carbonate >99.5% were added in a mixer, subsequently butylated hydroxytoluene (BHT) was added, subsequently saflufenacil 96% powder, then a solution of 10EO tallow amine (Ethomeen® T/20), cocoamidopropylbetaine (Adsee® C80W) and finally water (Table 1). Table 1 – Components of the first ME composition [0077] After preparing the formulation in Table 1, its physicochemical parameters were evaluated, as shown in Table 2.
  • composition as in the previous example, underwent stability analyzes that proved it to be a stable microemulsion, without the formation of crystals or cloudiness, after 14 days at temperatures of 5 and 54°C.
  • the saflufenacil sample was analyzed by the CL6222065 method, using a DAD detector, in a wavelength 260.4 nm, using a Phenomenex Gemini column (150 mm x 4.5 mm x 5 ⁇ m) LFQ 023, with an HPLC grade filtered and degassed acetonitrile mobile phase and water 0.1% phosphoric acid (70:30 ), using a flow rate of 1.0 mL/min, an injection volume of 5 ⁇ L, temperature 40oC, retention time ⁇ 2.4 minutes and run time 5 minutes.
  • the composition according to this invention is a stable microemulsion of saflufenacil, as it has reached very low levels of degradation, according to the analysis carried out in HPLC.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to a new microemulsion (ME) composition comprising saflufenacil and comprising at least one nitrogen non-ionic surfactant. In addition, the present invention relates to a process for preparing the ME composition, as well as to the use thereof as a herbicide. Finally, the present invention relates to a process for controlling the growth of undesirable plants.

Description

COMPOSIÇÃO DE MICROEMULSÃO DE SAFLUFENACIL, SEU PROCESSO DE PREPARAÇÃO E USO CAMPO DA INVENÇÃO [001] A presente invenção se refere a uma nova composição de microemulsão (ME) compreendendo saflufenacil. Adicionalmente, a presente invenção se refere a um processo para a preparação da composição ME, bem como seu uso como um herbicida. Finalmente, a presente invenção se refere a um processo para o controle de crescimento de plantas indesejáveis. ANTECEDENTES DA INVENÇÃO [002] O agronegócio representa um importante setor para a economia de diversos países, como é o caso do Brasil e Estados Unidos. Não obstante, essa área enfrenta alguns problemas relacionados à sua produção, especialmente devido à resistência criada aos pesticidas mais comuns e dificuldade em se obter novas formulações estáveis. [003] As pragas agrícolas vegetais causam danos significativos aos cultivos, comprometendo tanto sua quantidade quanto sua qualidade. Nesse sentido, é crescente a busca pelo controle do número de pragas, a fim de impedir que a interferência sobre as plantas cultivadas cause impactos negativos na produção econômica (PATEL, 2018). [004] Particularmente, os ingredientes ativos insolúveis em água representam um gargalo tecnológico quando se tratada da preparação de novas composições agroquímicas. As soluções existentes apresentam problemas de instabilidade, devido a criação de cristais ou separação de fase, além de problemas relacionados ao seu rendimento, prejudicado por situações que ocorrem no campo, como por exemplo, calor excessivo. [005] Os custos de produção de plantas cultivadas, associados à presença de pragas que ganham resistência aos atuais pesticidas, vêm aumentado a cada ano. Por esse motivo, estratégias antirresistência são amplamente empregadas no campo, a fim de se diminuir os prejuízos. O uso de pesticidas com diferentes mecanismos de ação (aplicados em associação ou isoladamente) e estratégias de uso dos mesmos, se destacam dentre tais estratégias (GEMELLI et al., 2012). Saflufenacil é um exemplo de herbicida usualmente empregado em culturas resistente ao glifosato e/ou herbicidas inibidores de ALS. [006] O saflufenacil se enquadra nos agroquímicos de alta eficiência, porém baixa solubilidade em meios líquidos, incluindo água, tornando-se um desafio conseguir formulações estáveis que contenham esse ingrediente ativo. Apesar da baixa solubilidade do saflufenacil, formulações contendo água como solvente são altamente interessantes, pois evitam ou diminuem o uso de solventes agressivos ao meio ambiente, mais custosos e menos seguros para o uso humano. [007] WO2021038439 apresenta uma formulação de solução concentrada (SL) de saflufenacil e uma base orgânica. As formulações de WO2021038439 que contém apenas saflufenacil como o ingrediente ativo apresentam uma alta carga de tensoativos, encarecendo esse produto, o que pode torná-lo comercialmente inviável. Além disso, formulações SL são comumente reconhecidas por terem baixo espalhamento e baixa resistência à chuva no campo. [008] WO2017037210 apresenta uma composição de microcápsulas compreendendo saflufenacil. Apesar das conhecidas vantagens do microencapsulamento de ingredientes ativos, esses produtos são difíceis de se obter e seus processos de produção custosos. [009] Portanto, existe uma necessidade em se desenvolver formulações aquosas contendo saflufenacil que sejam mais estáveis e comercialmente viáveis. Diante desse cenário, as formulações na forma de microemulsões (ME) se mostraram promissoras. [0010] As MEs são formulações transparentes e termodinamicamente estáveis em uma ampla faixa de temperatura, com gotas emulsificadas de aproximadamente 0,01 e 0,05 µm, à base de água. Ao contrário de outros sistemas, as MEs não apresentam facilmente separação de fase. Consequentemente, esse tipo de formulação tem uma vida de prateleira maior, vantajosamente emprega água como um dos seus solventes, é fácil de transportar e armazenar e, mais importante ainda, entrega um efeito de defensivo agrícola melhorado devido à solubilização do ingrediente ativo nas microgotas. [0011] BR 11 2020 017457 2 apresenta uma composição herbicida compreendendo um composto herbicidamente ativo compreendendo um composto à base de pirimidinadiona, e um melhorador de eficácia, como por exemplo, tensoativos à base de óleo de mamona, etoxilados ou polioxietileno monolaurato de sorbitana. Não obstante, os referidos melhorados de eficácia não são adequados para a preparação de formulações ME compreendendo saflufenacil, pois causam a cristalização do ingrediente ativo. [0012] Assim, pode-se notar que para alcançar formulações ME estáveis existe um extenso caminho de experimentações que precisam ser realizadas. Não se configura tarefa fácil a obtenção dos componentes e processos adequados de produção de uma composição de microemulsão, especialmente microemulsão compreendendo saflufenacil como ingrediente ativo. [0013] A presente invenção reduz a contaminação do solo, lençóis freáticos, rios, entre outros ambientes que entraram em contato com o referido defensivo agrícola, uma vez que a referida invenção diminuí a quantidade necessária de defensivos agrícolas no campo, pois aumenta a eficiência dos ingredientes ativos da formulação. SUMÁRIO DA INVENÇÃO [0014] A presente invenção se refere a uma composição de microemulsão compreendendo saflufenacil, seus sais ou seus N-óxidos, e tensoativos não-iônicos nitrogenados. [0015] Ainda, a presente invenção se refere a um processo de preparação da referida composição, o qual é capaz de obter uma formulação estável, sem formação de cristais ou separação de fases. [0016] Adicionalmente, a presente invenção se refere a um processo para o controle de pragas agrícolas, como por exemplo, Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., e Xanthium strumarium L., incluindo biótipos resistentes a triazina e ALS, e outras pragas agrícolas, especialmente em culturas de soja, legumes, frutas, citros, leguminosas, vegetais, favas, tubérculos, crucíferas, hortaliças, nozes, árvores, herbáceas, ervas, rosas, plantas ornamentais, pastagens, ou qualquer outro cultivo afetado por tais plantas indesejáveis. [0017] Ademais, a presente invenção se refere ao uso da referida composição como um herbicida. [0018] A invenção ora descrita alcança melhores resultados de rendimento de produção de plantas de cultivo, pois aumenta a eficácia do ingrediente ativo ao entregar uma composição mais estável e com uma quantidade adequada do defensivo agrícola em sua formulação. DESCRIÇÃO DAS FIGURAS [0019] FIG. 1 – composição de microemulsão compreendendo saflufenacil totalmente translúcida. [0020] FIG. 2 - Cromatograma da solução primária repetição 1 de saflufenacil. [0021] Fig. 3 - Cromatograma da solução primária repetição 2 de saflufenacil. [0022] Fig. 4 - Cromatograma da solução primária repetição 3 de saflufenacil. [0023] FIG. 5 - Cromatograma da solução B de saflufenacil. [0024] Fig. 6 - Cromatograma da solução C de saflufenacil. [0025] Fig. 7 - Cromatograma da solução D de saflufenacil. DESCRIÇÃO DETALHADA DA INVENÇÃO [0026] A presente invenção se refere a uma composição de microemulsão compreendendo saflufenacil, seus sais ou seus N-óxidos, e tensoativos não-iônicos nitrogenados. [0027] Preferencialmente, a presente invenção se refere a uma composição de microemulsão compreendendo (i) saflufenacil, seus sais ou seus N-óxidos, (ii) pelo menos um solvente polar orgânico, (iii) pelo menos um tensoativo não- iônico nitrogenado e (iv) pelo menos um co-tensoativo anfotérico. [0028] O referido saflufenacil está presente em uma faixa de 15% a 35% do peso total da composição. [0029] O referido pelo menos um solvente polar orgânico é selecionado entre aldeídos, alquilnitrilas, alcanos, amidas, aminas, cetonas, ésteres, nitrilas, hidrocarbonetos substituídos aromáticos, hidrocarbonetos substituídos alifáticos, hidrocarbonetos substituídos cicloalifáticos, hidrocarbonetos halogenados, nitroalcanos, sulfóxidos, sulfonas, seus derivados ou suas misturas. [0030] Preferencialmente, o referido pelo menos um solvente polar orgânico é selecionado entre formilmorfolina, N-formilmorfolina, dimetilacetamida, N,N-dimetilacetamida, dimetilformamida, N,N′-dimetilpropilenoureia, formamida, metilformamida, N-metilformamida, N,N-dimetilformamida, tetrametilureia, N-vinilacetamida, octanamida, N,N-dimetil + decanamida, N,N-dimetil, 2-pirrolidona, N- metilpirrolidona, N-vinilpirrolidona, dimetilsulfóxido, dietilsulfóxido, carbonato de propileno, 4-etil-1,3- dioxolan-2-ona, 4-(metoximetil)-1,3-dioxolan-2-ona, seus derivados ou suas misturas. Esse composto está presente em uma faixa de 10% a 65% do peso total da composição. [0031] O referido pelo menos um tensoativo não- iônico nitrogenado é selecionado entre aminas oxidadas, alquilamidas, alcoóis graxos etoxilados com amina, etoxilados de amina, polímeros de óxido de propileno e óxido de etileno com amina, imidazolina, amidas de ácidos graxos etoxilados, suas misturas ou seus derivados. [0032] Preferencialmente, os referidos tensoativos não-iônicos nitrogenados são selecionados entre amina de sebo 10 EO, N-óxido de laurilamina, cocamida DEA, laurilamina etoxilada, amina etoxilada de óleo de tálamo, lauramida DEA, amina laurílica etoxilada, amina de soja etoxilada, amina oleílica etoxilada, amina esteárica etoxilada, óxido de dimetil-dodecilamina, óxido de oleildi(2-hidroxietil)amina, óxido de dimetiltetradecilamina, óxido de di(2-hidroxietil)- tetradecilamina, óxido de dimetilhexadecilamina, óxido de beenamina, óxido de cocamina, óxido de deciltetradecilamina, óxido de dihidroxietil C12-C15 alcoxipropilamina, óxido de dihidroxietil cocamina, óxido de di-hidroxietil lauramina, óxido de di-hidroxietil estearamina, óxido de di-hidroxietil lauramina, óxido de amina de palmiste hidrogenado, óxido de sebo de palma hidrogenado, óxido de hidroxietil hidroxipropil C12-C15 alcoxipropilamina, óxido de miristamina, seus derivados ou suas misturas. Esse composto está presente em uma faixa de 5% a 50% do peso total da composição. [0033] De maneira surpreendente, foi descoberto que na ausência de tensoativos não-iônicos nitrogenados, a composição de microemulsão de saflufenacil inicia a formação de cristais. [0034] O referido pelo menos um co-tensoativo anfotérico é selecionado entre betaínas, anfoacetato, sulfobetaína, imidazolina, propianato, acetato, quartenário de amônio, seus derivados e suas misturas. [0035] Preferencialmente, o referido pelo menos um co-tensoativo anfotérico é selecionado entre cocoamidobetaína, lauramidopropil betaína, coco-betaína, ácido de cocoamfoacetato, ácido lauramfoacetato, sulfobetaína e imidazolina, seus derivados ou suas misturas. Esse composto está presente em uma faixa de 1% a 15% do peso total da composição. [0036] Finalmente, água deve estar presente na formulação em uma concentração entre 0,1% a 25% do peso total da composição. A presença de água não apenas evita o uso excessivo de outros solventes mais agressivos para o meio ambiente, como também diminui os custos de produção da formulação, além de permitir a formação da microemulsão. [0037] Ainda, a formulação da presente invenção pode ser empregada conjuntamente com outros defensivos agrícolas adicionais. [0038] Os referidos defensivos adicionais são selecionados entre herbicidas pertencentes a classes de inibidores de acetil CoA carboxilase (ACCase), inibidores de HPPD, inibidores de glutamato sintase, inibidores de ácido acetolactato sintase (ALS), inibidores de EPSP sintase, inibidores de síntese de lipídios, inibidores de transporte de auxina, inibidores de ácido graxo de cadeia muito longa, inibidores de biossíntese de carotenoides, inibidores de microtúbulo, inibidores de fotossistema, inibidores de PPO, suas misturas ou derivados. [0039] O inibidor de ACCase é selecionado entre aloxidima, cletodima, cialofope, clodinafope, diclofope, fenoxaprope, fluazifope, fenoxaprope-P, haloxifope, metamifope, propaquizafope, quizalofope, setoxidima, tepraloxidima, tralcoxidima e pinoxadeno, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0040] O inibidor de ALS é selecionado entre amidossulfurona, azimsulfurona, bensulfurona, bencarbazona, bispiribaque, clorimurona, cloransulam, ciclossulfamurona, etoxissulfurona, diclosulam, florasulam, flumetsulam, flazassulfurona, flucarbazona, flucetossulfurona, flupirsulfurona, foramsulfurona, halossulfurona, imazossulfurona, ipfencarbazona, mesossulfurona, metazossulfurona, nicossulfurona, ortossulfamurona, oxassulfurona, primissulfurona, propirissulfurona, pirazossulfurona, rimsulfurona, sulfomeclomazoturona, sulfometurona-metila, sulfossulfurona, trifloxissulfurona, clorsulfurona, cinossulfurona, etametsulfurona, iodossulfurona, imazametabenzo, imazamox, imazapique, imazapir, imazaquina, imazetapir, iofensulfurona, metosulam, metsulfurona, penoxsulam, piroxsulam, piritiobaque, piriminobaque, piribenzoxim, pirimissulfano, piriftalida, propoxicarbazona, prossulfurona, tiencarbazona, tifensulfurona, triassulfurona, tribenuron, triflussulfurona, triflussulfurona-metila, tritossulfurona, tiencarbazona, e triafamona, seus derivados, sais e N- óxidos, ou misturas dos mesmos. [0041] O inibidor de EPSP sintase é selecionado entre glifosato, sulfosato, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0042] O inibidor de transporte de auxina é selecionado entre diflufenzopir e naptalam, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0043] O inibidor de glutamato sintase é selecionado entre glufosinato e bialafós, seus derivados, sais e N- óxidos, ou misturas dos mesmos. [0044] O inibidor de HPPD é selecionado entre benzobiciclona, benzofenape, biciclopirona, fenquinotriona, isoxaclorotol, isoxaflutol, mesotriona, sulcotriona, pirassulfotol, pirazolinato, pirazoxifeno, tefuriltriona, tembotriona, tolpiralato e topramezona, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0045] O inibidor de síntese de lipídios é selecionado entre butilato, cicloato, eptc, eptam, tiobencarbe, trialato, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0046] O inibidor de biossíntese de carotenoide é selecionado entre beflubutamida, diflufenicano, fluridona, fluorocloridona, flurtamona picolinafeno, norflurazona, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0047] O inibidor de ácido graxo de cadeia longa é selecionado entre alacloro, acetocloro, anilofós butacloro, cafenstrola, dimetenamida, dimetenamida-P, fenoxassulfona, fentrazamida, flufenaceto, indanofano, metazacloro, metolacloro, mefenaceto, naproanilida, pretilacloro, piroxassulfona, propacloro, S-metolacloro, e tenilcloro, seus derivados, sais e N-óxidos, ou misturas dos mesmos. [0048] O inibidor de fotossistema é selecionado entre ioxinila, octanoato de ioxinila, bentazona, piridato, bromoxinila, octanoato de bromoxinila, clorotolurona, dimefurona, diurona, linurona, fluometurona, isoproturona, isourona, tebutiurona, benztiazurona, metabenztiazurona, propanila, metobromurona, metoxurona, monolinurona, sidurona, simazina, atrazina, propazina, cianazina, ametrina, simetrina, dimetametrina, prometrina, terbumetona, terbutilazina, terbutrina, trietazina, hexazinona, metamitrona, metribuzina, amicarbazona, bromacila, lenacila, terbacila, cloridazona, desmedifame e fenmedifame. [0049] A quantidade do pesticida adicional na composição ou a ser aplicado no campo irá depender do tipo de pesticida a ser utilizado e seu fabricante. As referidas quantidades são conhecidas do estado da técnica, especialmente porque os pesticidas ora mencionados são amplamente empregados no campo dessa invenção. Cada pesticida adicional do estado da técnica é acompanhado de uma bula, a qual indicará a dosagem adequada de aplicação no campo. Posto isto, as quantidades ora mencionadas não têm o intuito de limitar a presente invenção, mas apenas melhor definir a matéria objeto de proteção. [0050] Opcionalmente, a composição da presente invenção compreende ainda outros adjuvantes ou compostos capazes de melhorar uma propriedade especifica da composição como, por exemplo, sua solubilidade ou efeito pesticida. [0051] Os referidos adjuvantes ou outros compostos capazes de melhorar uma propriedade especifica da composição compreendem compostos alquil éster etoxilado do ácido fosfórico, ésteres metílicos ou ésteres metílicos de ácido graxo, complexos metálicos, complexos de compostos inorgânicos ou orgânicos, hidrocarbonetos aromáticos, ácidos graxos insaturados ou saturados, um ou mais compostos básicos, um ou mais ácidos, sais, macro ou micronutrientes, diluentes, sólidos orgânicos ou inorgânicos, agentes de carga, agentes conservantes, agentes antioxidantes, agentes umectantes, agentes dispersantes, transportadores sólidos, agentes de suspensão ou antisedimentação, auxiliadores de absorção ou adsorção, agentes adesivos, agentes desintegrantes, estabilizantes, anticongelantes, anticristalizantes, polímeros ou copolímeros, óleos minerais, vegetais, organosiliconados, solúveis ou insolúveis em água, orgânicos ou inorgânicos, ou suas misturas, e quaisquer outros componentes presentes em formulações do estado da técnica e amplamente empregadas no campo de aplicação da invenção. [0052] Preferencialmente, a referida composição compreende (v) pelo menos um agente anticristalizante e (vi) pelo menos um agente conservante. [0053] O referido pelo menos um agente anticristalizante é selecionado entre copolímeros, polímeros, glicóis, ésteres fosfóricos, ácidos graxos e seus sais, sais solúveis, sacarídeos, polissacarídeos, ésteres de ácidos graxos, aminas, silicones, ésteres de polioxietileno, agentes quelantes, agentes temponantes, seus derivados e suas misturas. [0054] Preferencialmente, o referido pelo menos um agente anticristalizante é selecionado entre copolímero em bloco de óxido de polialquileno, polietilenoglicol, polivinilpirrolidona, etanol, propileno glicol, seus derivados e suas misturas. [0055] O referido pelo menos um agente conservante é selecionado entre fenólicos, compostos orgânicos aromáticos, tiazolinas e isotiazolinonas, parabenos, formaldeídos, alcóois, dióis, ácidos, oxidantes, derivados de piridina, ácidos orgânicos, sais de amônio quaternário, aldeídos, seus derivados e suas misturas. [0056] Preferencialmente, o referido pelo menos um agente conservante é selecionado entre di-terc-butil metil fenol (BHT), benzimidazol, metilisotiazolinona, metilcloroisotiazolinona, metilparabeno, propilparabeno, tiabendazol, fenoxietanol, benzisotiazolinona, clorometilisotiazolinona, bronopol (2-bromo-2-nitropropano- 1,3-diol), ácido benzoico, ácido sórbico e seus sais, seus derivados e suas misturas. [0057] Os referidos compostos adicionais estão presentes em uma faixa de 0,01 a 10%, preferencialmente em uma concentração de 0,5% a 5% do peso total da composição. [0058] Opcionalmente, dentro das modalidades acima descritas, a composição ora descrita pode estar na forma de formulações “ready mix” ou “in can”. [0059] Ainda, a presente invenção se refere a um processo de preparação da composição como ora descrita, que compreende as etapas de: a) adicionar o pelo menos um solvente polar orgânico; b) adicionar o pelo menos um tensoativo não-iônico nitrogenado; c) adicionar o pelo menos um co-tensoativo anfotérico; d) adicionar saflufenacil; em que os compostos das etapas a) até d) permanecem em constante agitação. [0060] Opcionalmente, o processo compreende as etapas de: a) adicionar o pelo menos um solvente polar orgânico; b) adicionar o pelo menos um tensoativo não-iônico nitrogenado; c) adicionar o pelo menos um co-tensoativo anfotérico; d) adicionar o pelo menos um agente conservante; e) adicionar saflufenacil; e f) adicionar o pelo menos um agente anticristalizante, em que os compostos das etapas a) até f) permanecem em constante agitação. [0061] A agitação dessa mistura deve ser mantida em uma agitação entre 250 a 1000rpm, preferencialmente entre 700 e 800 rpm, com o intuito de manter a mistura homogeneizada durante todo o processo. [0062] Preferencialmente, na etapa a), são adicionados pelo menos dois solventes polares orgânicos, em que um dos solventes polares orgânicos é selecionado entre uma amina ou aldeído, e o outro solvente orgânico polar é selecionado entre amidas, numa proporção entre si de 1:1 até 1:2,5, respectivamente. [0063] Preferencialmente, o pelo menos um agente anticristalizante deve ser previamente fundido. [0064] Após adição de todos os ingredientes acima, água pode ser adicionado à mistura. [0065] O pH da formulação deve estar entre 5,5 a 8,0, preferencialmente entre 6,0 e 8,0, uma vez que em faixas diferentes de pH o saflufenacil pode degradar. Para o ajuste do referido pH devem ser adicionados ácidos ou bases fracos, a depende do pH final da formulação, como ácido cítrico, ácido clorídrico, ácido sulfúrico, hidróxido de sódio, hidróxido de amônio, hidróxido de potássio, ou qualquer outro ácido ou base fracos conhecidos do estado da técnica. [0066] O processo de preparação deve ser realizado em temperaturas entre 5ºC até 40ºC. [0067] Adicionalmente, a presente invenção se refere a um processo para o controle de crescimento de plantas indesejáveis, como por exemplo, Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., e Xanthium strumarium L., incluindo biótipos resistentes a triazina e ALS, e outras pragas agrícolas. [0068] O processo de controle de plantas indesejáveis compreende a aplicação da composição de microemulsão (ME) compreendendo saflufenacil dessa invenção, especialmente em culturas de soja, legumes, frutas, citros, leguminosas, vegetais, favas, tubérculos, crucíferas, hortaliças, nozes, árvores, ervas, herbáceas, rosas, plantas ornamentais, pastagens, preferencialmente, os cultivos são selecionados entre cebola, abacaxi, amendoim, aspargo, beterraba sacarina, nabo, canola nabo-sueco, couve-chinesa, Camellia sinensis, cártamo, noz-pecã, limão, laranja, café, pepino, capim, cenoura, palma de óleo, morango, algodão, girassol, seringueira, cevada, lúpulo, batata, batata-doce, noz-comum, lentilha, linho, tomate, maçã, mandioca, alfafa, banana, tabaco, oliveira, arroz, feijão-lima, fava, feijão, pinheiro da Noruega, pinheiro, ervilha, damasco, cereja- doce, cereja-ácida, amêndoa, ameixa, pêssego, pera, groselha, mamona, cana-de-açúcar, centeio, sorgo, cacau, trevo-vermelho, trigo (comum), trigo duro, uva, milho, ou qualquer outro cultivo que seja afetado por tais plantas indesejáveis, por meio da aplicação da composição dessa invenção à planta e/ou seu habitat. [0069] O controle do crescimento plantas indesejáveis incluí a prevenção, morte, redução ou retardamento do seu crescimento. [0070] Ademais, as formulações da presente invenção podem ser aplicadas pelo método de pré- ou pós-emergência, e pré-plantio incorporado a depender da planta indesejável a ser eliminada. Particularmente, saflufenacil é comumente empregado para o controle pós. [0071] As taxas de aplicação da combinação podem variar a depender de diversos fatores, que são amplamente conhecidos na área de aplicação dessa invenção, como por exemplo, da natureza do solo, do método de aplicação (pós- emergência; tratamento foliar; tratamento de sementes; aplicação no sulco da semente; etc.), da planta de cultivo, das pragas agrícolas indesejáveis a serem controladas, das condições climáticas no momento da aplicação e de outros fatores. [0072] No entanto, sem o intuito de limitar as formas de concretização dessa invenção, a vazão de aplicação de saflufenacil pode ser de 15 a 500, preferencialmente de 30 a 150 g/ha. [0073] A aplicação no campo pode ser realizada por pulverização da combinação, polvilhamento, gotejamento, rega, ou injeção ao solo, a depender da estrutura que o aplicador apresenta, bem como a forma da combinação. [0074] Ainda, a presente invenção se refere ao uso dessa composição como uma composição herbicida, para eliminar ou reduzir o crescimento de plantas indesejáveis. [0075] Os exemplos ora descritos não têm o intuito de limitar o escopo dessa invenção, mas pretendem comprovar que experimentações adicionais precisaram ser desenvolvidas para alcançar o processo de produção correto da composição ora reivindicada. EXEMPLO 1 [0076] Para a preparação de uma primeira composição ME foram adicionados, em um misturador, formilmorfolina >99% e carbonato de propileno >99,5%, posteriormente foi adicionado hidroxitolueno butilado (BHT), subsequentemente saflufenacil 96% em pó, em seguida uma solução de amina de sebo 10EO (Ethomeen® T/20), de cocoamidopropilbetaína (Adsee® C80W) e finalmente água (Tabela 1). Tabela 1 – Componentes da primeira composição ME
Figure imgf000019_0001
[0077] Após a preparação da formulação da Tabela 1, seus parâmetros físico-químicos foram avaliados, conforme mostrado na Tabela 2. Tabela 2 – Parâmetros físico-químicos de estabilidade
Figure imgf000020_0001
[0078] A partir dos resultados acima, comprovou-se que a composição de acordo com a invenção foi efetiva na preparação de uma composição ME estável (FIG. 1). Isto porque mesmo após 14 dias em temperaturas de 5 e 54ºC, as formulações continuaram límpidas, e a formulação se manteve como uma microemulsão. EXEMPLO 2 [0079] Para a preparação de uma segunda composição ME (Tabela 3) foram adicionados, em um misturador, formilmorfolina >99% e octanamida, N,N-dimetil + decanamida, N,N-dimetil (Armid® 810), em velocidade de agitação de 800 rpm. Posteriormente, foram adicionados amina de sebo 10 EO (Ethomeen® T/20), cocoamidopropilbetaína (Adsee® C80W) e hidroxitolueno butilado (BHT), nessa ordem. Em sequência, saflufenacil 97% em pó foi incluído, e mantido sob agitação para completa solubilização. Em seguida, copolímero em bloco EO/PO (Atlas® G5000), previamente fundido, foi adicionado e mantido sob agitação até completa solubilização. Por fim, água completou o volume da mistura e concluiu a sua homogeneização. Tabela 3 – Componentes da segunda composição ME
Figure imgf000020_0002
Figure imgf000021_0001
SAFLUFENACIL MICROEMULSION COMPOSITION, ITS PREPARATION PROCESS AND USE FIELD OF THE INVENTION [001] The present invention relates to a new microemulsion composition (ME) comprising saflufenacil. Additionally, the present invention relates to a process for preparing the ME composition, as well as its use as a herbicide. Finally, the present invention relates to a process for controlling the growth of undesirable plants. BACKGROUND OF THE INVENTION [002] Agribusiness represents an important sector for the economy of several countries, such as Brazil and the United States. However, this area faces some problems related to its production, especially due to the resistance created to the most common pesticides and the difficulty in obtaining new stable formulations. [003] Agricultural plant pests cause significant damage to crops, compromising both their quantity and quality. In this sense, there is a growing search for controlling the number of pests, in order to prevent interference with cultivated plants from causing negative impacts on economic production (PATEL, 2018). [004] In particular, water-insoluble active ingredients represent a technological bottleneck when it comes to preparing new agrochemical compositions. Existing solutions present instability problems, due to the creation of crystals or phase separation, in addition to problems related to their performance, which is hampered by situations that occur in the field, such as excessive heat. [005] The production costs of cultivated plants, associated with the presence of pests that gain resistance to current pesticides, have been increasing every year. For this reason, anti-resistance strategies are widely used in the field, in order to reduce losses. The use of pesticides with different mechanisms of action (applied in combination or alone) and strategies for using them stand out among such strategies (GEMELLI et al., 2012). Saflufenacil is an example of a herbicide usually used in crops resistant to glyphosate and/or ALS-inhibiting herbicides. [006] Saflufenacil belongs to agrochemicals with high efficiency, but low solubility in liquid media, including water, making it a challenge to obtain stable formulations that contain this active ingredient. Despite the low solubility of saflufenacil, formulations containing water as a solvent are highly interesting, as they avoid or reduce the use of solvents that are harmful to the environment, more expensive and less safe for human use. [007] WO2021038439 presents a concentrated solution (SL) formulation of saflufenacil and an organic base. The formulations of WO2021038439 that contain only saflufenacil as the active ingredient have a high load of surfactants, making this product more expensive, which may make it commercially unviable. Furthermore, SL formulations are commonly recognized for having low spreading and poor resistance to rain in the field. [008] WO2017037210 presents a composition of microcapsules comprising saflufenacil. Despite the known advantages of microencapsulation of active ingredients, these products are difficult to obtain and their costly production processes. [009] Therefore, there is a need to develop aqueous formulations containing saflufenacil that are more stable and commercially viable. Given this scenario, formulations in the form of microemulsions (ME) have shown promise. [0010] MEs are transparent and thermodynamically stable formulations over a wide temperature range, with emulsified droplets of approximately 0.01 and 0.05 µm, based on water. Unlike other systems, MEs do not readily exhibit phase separation. Consequently, this type of formulation has a longer shelf life, advantageously uses water as one of its solvents, is easy to transport and store and, most importantly, delivers an improved agricultural pesticide effect due to the solubilization of the active ingredient in the microdroplets. [0011] BR 11 2020 017457 2 presents a herbicidal composition comprising a herbicidally active compound comprising a pyrimidinedione-based compound, and an efficacy enhancer, such as, for example, castor oil-based surfactants, ethoxylates or polyoxyethylene sorbitan monolaurate. However, said efficacy enhancers are not suitable for the preparation of ME formulations comprising saflufenacil, as they cause crystallization of the active ingredient. [0012] Thus, it can be noted that to achieve stable ME formulations there is an extensive path of experimentation that needs to be carried out. It is not an easy task to obtain the components and processes suitable for producing a microemulsion composition, especially a microemulsion comprising saflufenacil as an active ingredient. [0013] The present invention reduces the contamination of soil, groundwater, rivers, among other environments that came into contact with said agricultural pesticide, since said invention reduces the necessary amount of agricultural pesticides in the field, as it increases efficiency of the active ingredients of the formulation. SUMMARY OF THE INVENTION [0014] The present invention relates to a microemulsion composition comprising saflufenacil, its salts or its N-oxides, and nitrogenous non-ionic surfactants. [0015] Furthermore, the present invention refers to a process for preparing said composition, which is capable of obtaining a stable formulation, without the formation of crystals or phase separation. [0016] Additionally, the present invention relates to a process for controlling agricultural pests, such as Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp. , Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., and Xanthium strumarium L., including biotypes resistant to triazine and ALS, and other agricultural pests, especially in soybean crops, vegetables, fruits, citrus, legumes, vegetables, broad beans, tubers, crucifers, vegetables, nuts, trees, herbaceous plants, herbs, roses, ornamental plants, pastures, or any other crop affected by such undesirable plants. [0017] Furthermore, the present invention relates to the use of said composition as a herbicide. [0018] The invention now described achieves better results in the production yield of crop plants, as it increases the effectiveness of the active ingredient by delivering a more stable composition and with an adequate amount of the agricultural pesticide in its formulation. DESCRIPTION OF FIGURES [0019] FIG. 1 – microemulsion composition comprising fully translucent saflufenacil. [0020] FIG. 2 - Chromatogram of the primary saflufenacil repeat 1 solution. [0021] Fig. 3 - Chromatogram of the saflufenacil repeat 2 primary solution. [0022] Fig. 4 - Chromatogram of the saflufenacil repeat 3 primary solution. [0023] FIG. 5 - Chromatogram of saflufenacil solution B. [0024] Fig. 6 - Chromatogram of saflufenacil solution C. [0025] Fig. 7 - Chromatogram of saflufenacil solution D. DETAILED DESCRIPTION OF THE INVENTION [0026] The present invention relates to a microemulsion composition comprising saflufenacil, its salts or its N-oxides, and nitrogenous non-ionic surfactants. [0027] Preferably, the present invention relates to a microemulsion composition comprising (i) saflufenacil, its salts or its N-oxides, (ii) at least one organic polar solvent, (iii) at least one nitrogenous non-ionic surfactant and (iv) at least one amphoteric co-surfactant. [0028] Said saflufenacil is present in a range of 15% to 35% of the total weight of the composition. [0029] Said at least one organic polar solvent is selected from aldehydes, alkylnitriles, alkanes, amides, amines, ketones, esters, nitriles, aromatic substituted hydrocarbons, aliphatic substituted hydrocarbons, cycloaliphatic substituted hydrocarbons, halogenated hydrocarbons, nitroalkanes, sulfoxides, sulfones , their derivatives or their mixtures. [0030] Preferably, said at least one organic polar solvent is selected from formylmorpholine, N-formylmorpholine, dimethylacetamide, N,N-dimethylacetamide, dimethylformamide, N,N′-dimethylpropyleneourea, formamide, methylformamide, N-methylformamide, N,N -dimethylformamide, tetramethylurea, N-vinylacetamide, octanamide, N,N-dimethyl + decanamide, N,N-dimethyl, 2-pyrrolidone, N-methylpyrrolidone, N-vinylpyrrolidone, dimethylsulfoxide, diethylsulfoxide, propylene carbonate, 4-ethyl-1 ,3-dioxolan-2-one, 4-(methoxymethyl)-1,3-dioxolan-2-one, derivatives thereof or mixtures thereof. This compound is present in a range of 10% to 65% of the total weight of the composition. [0031] Said at least one nitrogenous non-ionic surfactant is selected from oxidized amines, alkylamides, amine ethoxylated fatty alcohols, amine ethoxylates, polymers of propylene oxide and amine ethylene oxide, imidazoline, ethoxylated fatty acid amides, mixtures thereof or derivatives thereof. [0032] Preferably, said nitrogenous non-ionic surfactants are selected from tallow amine 10 EO, laurylamine N-oxide, cocamide DEA, ethoxylated laurylamine, ethoxylated thalamus oil amine, lauramide DEA, ethoxylated lauryl amine, soy amine ethoxylated, ethoxylated oleyl amine, ethoxylated stearic amine, dimethyldodecylamine oxide, oleyldi(2-hydroxyethyl)amine oxide, dimethyltetradecylamine oxide, di(2-hydroxyethyl)tetradecylamine oxide, dimethylhexadecylamine oxide, behenamine oxide, oxide cocamine, decyltetradecylamine oxide, dihydroxyethyl C12-C15 alkoxypropylamine oxide, dihydroxyethyl cocamine oxide, dihydroxyethyl lauramine oxide, dihydroxyethyl stearamine oxide, dihydroxyethyl lauramine oxide, hydrogenated palm kernel amine oxide, hydrogenated palm tallow, hydroxyethyl hydroxypropyl C 12 -C 15 alkoxypropylamine oxide, myristamine oxide, their derivatives or mixtures thereof. This compound is present in a range of 5% to 50% of the total weight of the composition. [0033] Surprisingly, it was discovered that in the absence of nitrogenous non-ionic surfactants, the saflufenacil microemulsion composition initiates the formation of crystals. [0034] Said at least one amphoteric co-surfactant is selected from betaines, amphoacetate, sulfobetaine, imidazoline, propianate, acetate, quaternary ammonium, its derivatives and mixtures. [0035] Preferably, said at least one amphoteric co-surfactant is selected from cocoamidobetaine, lauramidopropyl betaine, coco-betaine, cocoamfoacetate acid, lauramfoacetate acid, sulfobetaine and imidazoline, their derivatives or mixtures thereof. This compound is present in a range of 1% to 15% of the total weight of the composition. [0036] Finally, water must be present in the formulation in a concentration between 0.1% to 25% of the total weight of the composition. The presence of water not only avoids the excessive use of other solvents that are more aggressive to the environment, it also reduces the production costs of the formulation, in addition to allowing the formation of the microemulsion. [0037] Furthermore, the formulation of the present invention can be used in conjunction with other additional agricultural pesticides. [0038] Said additional pesticides are selected from among herbicides belonging to classes of acetyl CoA carboxylase (ACCase) inhibitors, HPPD inhibitors, glutamate synthase inhibitors, acetolactate synthase (ALS) inhibitors, EPSP synthase inhibitors, synthesis inhibitors of lipids, auxin transport inhibitors, very long chain fatty acid inhibitors, carotenoid biosynthesis inhibitors, microtubule inhibitors, photosystem inhibitors, PPO inhibitors, mixtures or derivatives thereof. [0039] The ACCase inhibitor is selected from aloxidime, clethodime, cialofop, clodinafop, diclofop, fenoxaprop, fluazifop, fenoxaprop-P, haloxyfop, metamifop, propaquizafop, quizalofop, sethoxydime, tepraloxidime, tralkoxidime and pinoxaden, their derivatives, salts and N-oxides, or mixtures thereof. [0040] The ALS inhibitor is selected from amidosulfuron, azimsulfuron, bensulfurone, bencarbazone, bispiribaque, chlorimurone, cloransulam, cyclosulfamurone, ethoxysulfuron, diclosulam, florasulam, flumetsulam, flazasulfuron, flucarbazone, flucetosulfuron, flupirsulfuron, foramsulfuron, imazosulfuron, ipfencarbazone, mesosulfuron, metazosulfuron, nicosulfuron, orthosulfamurone, oxasulfuron, primisulfuron, propyrisulfuron, pyrazosulfuron, rimsulfuron, sulfomeclomazoturone, sulfometurone-methyl, sulfosulfuron, trifloxysulfuron, chlorsulfuron, cynosulfuron, etametsulfuron, iodosulfuron, metabenzo, imazamox, imazapique, imazapyr, imazaquine, imazetapyr, iofensulfuron, metosulam, metsulfuron, penoxsulam, piroxsulam, pyritiobaque, piriminobaque, pyribenzoxim, pyrimisulfan, pyrifthalide, propoxycarbazone, prosulfuron, thiencarbazone, thifensulfuron, triasulfuron, tribenuron, triflusulfuron, triflusulfuron-methyl, tritosulfuron, thiencarbazone, and its derivatives, salts and N- oxides, or mixtures thereof. [0041] The EPSP synthase inhibitor is selected from glyphosate, sulfosate, their derivatives, salts and N-oxides, or mixtures thereof. [0042] The auxin transport inhibitor is selected from diflufenzopyr and naptalam, their derivatives, salts and N-oxides, or mixtures thereof. [0043] The glutamate synthase inhibitor is selected from glufosinate and bialaphos, their derivatives, salts and N-oxides, or mixtures thereof. [0044] The HPPD inhibitor is selected from benzobicyclone, benzofenape, biciclopyrone, phenquinotrione, isoxachlorotol, isoxaflutole, mesotrione, sulcotrione, pyrasulfotol, pyrazolinate, pyrazoxifene, tefuryltrione, tembotrione, tolpiralate and topramezone, their derivatives, salts and N-oxides, or mixtures thereof. [0045] The lipid synthesis inhibitor is selected from butylate, cycloate, eptc, eptam, thiobencarb, triallate, their derivatives, salts and N-oxides, or mixtures thereof. [0046] The carotenoid biosynthesis inhibitor is selected from beflubutamide, diflufenican, fluridone, fluorochloridone, flutamone picolinaphene, norflurazone, their derivatives, salts and N-oxides, or mixtures thereof. [0047] The long-chain fatty acid inhibitor is selected from alachlor, acetochlor, anilophos butachlor, cafenstrola, dimethenamid, dimethenamid-P, fenoxasulfone, fentrazamide, flufenacet, indanophane, metazachlor, metolachlor, mefenacet, naproanilide, pretylachlor, pyroxasulfone, propachlor , S-metolachlor, and tenylchlor, their derivatives, salts and N-oxides, or mixtures thereof. [0048] The photosystem inhibitor is selected from ioxynyl, ioxynyl octanoate, bentazone, pyridate, bromoxynyl, bromoxynyl octanoate, chlorotolurone, dimefurone, diuron, linurone, fluometurone, isoproturone, isourone, tebuthiurone, benzthiazurone, metabenzthiazurone, propanyl, metobromurone, methoxurone, monolinuron, sidurone, simazine, atrazine, propazine, cyanazine, ametrine, simethrin, dimethethrin, promethrin, terbumetone, terbuthylazine, terbutrin, triethazine, hexazinone, metamitrone, metribuzin, amicarbazone, bromacil, lenacil, terbaccil, chloridazone, desmedipham and phenmedipham. [0049] The amount of additional pesticide in the composition or to be applied in the field will depend on the type of pesticide to be used and its manufacturer. Said quantities are known in the prior art, especially because the pesticides mentioned here are widely used in the field of this invention. Each additional state-of-the-art pesticide is accompanied by a leaflet, which will indicate the appropriate dosage for application in the field. That being said, the quantities mentioned here are not intended to limit the present invention, but only to better define the subject matter of protection. [0050] Optionally, the composition of the present invention also comprises other adjuvants or compounds capable of improving a specific property of the composition such as, for example, its solubility or pesticidal effect. [0051] Said adjuvants or other compounds capable of improving a specific property of the composition comprise phosphoric acid ethoxylated alkyl ester compounds, methyl esters or fatty acid methyl esters, metal complexes, complexes of inorganic or organic compounds, aromatic hydrocarbons, fatty acids unsaturated or saturated, one or more basic compounds, one or more acids, salts, macro or micronutrients, diluents, organic or inorganic solids, fillers, preservative agents, antioxidant agents, humectants, dispersing agents, solid carriers, suspending or anti-sedimentation agents, absorption or adsorption aids, adhesive agents, disintegrating agents, stabilizers, antifreezes, anticrystallizers, polymers or copolymers, mineral, vegetable, organosilicon oils, soluble or insoluble in water, organic or inorganic substances, or mixtures thereof, and any other components present in state-of-the-art formulations widely used in the field of application of the invention. [0052] Preferably, said composition comprises (v) at least one anticrystallizing agent and (vi) at least one preservative agent. [0053] Said at least one anticrystallizing agent is selected from copolymers, polymers, glycols, phosphoric esters, fatty acids and their salts, soluble salts, saccharides, polysaccharides, fatty acid esters, amines, silicones, polyoxyethylene esters, chelating agents , temponating agents, their derivatives and mixtures thereof. [0054] Preferably, said at least one anticrystallizing agent is selected from block copolymer of polyalkylene oxide, polyethylene glycol, polyvinylpyrrolidone, ethanol, propylene glycol, derivatives thereof and mixtures thereof. [0055] Said at least one preservative agent is selected from phenolics, aromatic organic compounds, thiazolines and isothiazolinones, parabens, formaldehydes, alcohols, diols, acids, oxidants, pyridine derivatives, organic acids, quaternary ammonium salts, aldehydes, their derivatives and their mixtures. [0056] Preferably, said at least one preservative agent is selected from di-tert-butyl methyl phenol (BHT), benzimidazole, methylisothiazolinone, methylchloroisothiazolinone, methylparaben, propylparaben, thiabendazole, phenoxyethanol, benzisothiazolinone, chloromethylisothiazolinone, bronopol (2-bromo- 2-nitropropane-1,3-diol), benzoic acid, sorbic acid and their salts, their derivatives and mixtures thereof. [0057] Said additional compounds are present in a range of 0.01 to 10%, preferably in a concentration of 0.5% to 5% of the total weight of the composition. [0058] Optionally, within the modalities described above, the composition now described may be in the form of “ready mix” or “in can” formulations. [0059] Furthermore, the present invention refers to a process for preparing the composition as described herein, which comprises the steps of: a) adding at least one organic polar solvent; b) add at least one nitrogenous non-ionic surfactant; c) adding at least one amphoteric co-surfactant; d) add saflufenacil; in which the compounds from steps a) to d) remain in constant agitation. [0060] Optionally, the process comprises the steps of: a) adding at least one organic polar solvent; b) add at least one non-ionic surfactant nitrogenous; c) adding at least one amphoteric co-surfactant; d) adding at least one preservative agent; e) add saflufenacil; and f) adding at least one anticrystallizing agent, whereby the compounds from steps a) to f) remain in constant agitation. [0061] The agitation of this mixture must be maintained at between 250 and 1000 rpm, preferably between 700 and 800 rpm, in order to keep the mixture homogenized throughout the process. [0062] Preferably, in step a), at least two organic polar solvents are added, in which one of the organic polar solvents is selected from an amine or aldehyde, and the other polar organic solvent is selected from amides, in a proportion to each other of 1:1 to 1:2.5, respectively. [0063] Preferably, the at least one anticrystallizing agent must be previously melted. [0064] After adding all of the above ingredients, water can be added to the mixture. [0065] The pH of the formulation must be between 5.5 and 8.0, preferably between 6.0 and 8.0, since in different pH ranges saflufenacil can degrade. To adjust this pH, weak acids or bases must be added, depending on the final pH of the formulation, such as citric acid, hydrochloric acid, sulfuric acid, sodium hydroxide, ammonium hydroxide, potassium hydroxide, or any other weak acid or base known in the art. [0066] The preparation process must be carried out at temperatures between 5ºC and 40ºC. [0067] Additionally, the present invention relates to a process for controlling the growth of undesirable plants, such as Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea , Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., and Xanthium strumarium L., including biotypes resistant to triazine and ALS, and other agricultural pests. [0068] The process of controlling undesirable plants comprises the application of the microemulsion (ME) composition comprising saflufenacil of this invention, especially in crops of soybeans, vegetables, fruits, citrus, legumes, vegetables, broad beans, tubers, crucifers, vegetables, nuts , trees, herbs, herbaceous plants, roses, ornamental plants, pastures, preferably, crops are selected from onion, pineapple, peanuts, asparagus, sugar beet, turnip, canola, turnip, Chinese cabbage, Camellia sinensis, safflower, walnut pecan, lemon, orange, coffee, cucumber, grass, carrot, oil palm, strawberry, cotton, sunflower, rubber tree, barley, hops, potato, sweet potato, common walnut, lentil, flax, tomato, apple, cassava, alfalfa, banana, tobacco, olive tree, rice, lima beans, broad beans, beans, Norway pine, pine, pea, apricot, sweet cherry, sour cherry, almond, plum, peach, pear, currant, castor, sugar cane, rye, sorghum, cocoa, red clover, wheat (common) , durum wheat, grapes, corn, or any other crop that is affected by such undesirable plants, through application of the composition of this invention to the plant and/or its habitat. [0069] Controlling the growth of undesirable plants includes preventing, killing, reducing or retarding their growth. [0070] Furthermore, the formulations of the present invention can be applied by the pre- or post-emergence method, and pre-planting incorporated depending on the undesirable plant to be eliminated. Particularly, saflufenacil is commonly used for post-treatment. [0071] The application rates of the combination may vary depending on several factors, which are widely known in the area of application of this invention, such as, for example, the nature of the soil, the method of application (post-emergence; foliar treatment; of seeds; application in the seed furrow; etc.), the crop plant, the undesirable agricultural pests to be controlled, the climatic conditions at the time of application and other factors. [0072] However, without the intention of limiting the forms of embodiment of this invention, the application rate of saflufenacil can be from 15 to 500, preferably from 30 to 150 g/ha. [0073] Field application can be carried out by spraying the combination, dusting, dripping, irrigation, or injection into the soil, depending on the structure that the applicator presents, as well as the form of the combination. [0074] Furthermore, the present invention relates to the use of this composition as a herbicidal composition, to eliminate or reduce the growth of undesirable plants. [0075] The examples now described are not intended to limit the scope of this invention, but are intended to prove that additional experiments needed to be developed to achieve the correct production process of the composition now claimed. EXAMPLE 1 [0076] To prepare a first ME composition, formylmorpholine >99% and propylene carbonate >99.5% were added in a mixer, subsequently butylated hydroxytoluene (BHT) was added, subsequently saflufenacil 96% powder, then a solution of 10EO tallow amine (Ethomeen® T/20), cocoamidopropylbetaine (Adsee® C80W) and finally water (Table 1). Table 1 – Components of the first ME composition
Figure imgf000019_0001
[0077] After preparing the formulation in Table 1, its physicochemical parameters were evaluated, as shown in Table 2. Table 2 – Physicochemical stability parameters
Figure imgf000020_0001
[0078] From the above results, it was proven that the composition according to the invention was effective in preparing a stable ME composition (FIG. 1). This is because even after 14 days at temperatures of 5 and 54ºC, the formulations remained clear, and the formulation remained as a microemulsion. EXAMPLE 2 [0079] For the preparation of a second ME composition (Table 3), formylmorpholine >99% and octanamide, N,N-dimethyl + decanamide, N,N-dimethyl (Armid® 810) were added to a mixer. at a stirring speed of 800 rpm. Subsequently, tallow amine 10 EO (Ethomeen® T/20), cocoamidopropylbetaine (Adsee® C80W) and butylated hydroxytoluene (BHT) were added, in that order. Next, saflufenacil 97% powder was included and kept under agitation for complete solubilization. Then, previously melted EO/PO block copolymer (Atlas® G5000) was added and kept under stirring until complete solubilization. Finally, water filled the volume of the mixture and completed its homogenization. Table 3 – Components of the second ME composition
Figure imgf000020_0002
Figure imgf000021_0001
[0080] A referida composição, assim como no exemplo anterior, passou por análises de estabilidade que comprovaram ser uma microemulsão estável, sem formação de cristais ou turvamentos, após 14 dias em temperaturas de 5 e 54°C. [0080] Said composition, as in the previous example, underwent stability analyzes that proved it to be a stable microemulsion, without the formation of crystals or cloudiness, after 14 days at temperatures of 5 and 54°C.
EXEMPLO 3 EXAMPLE 3
[0081] As formulações dos exemplos a seguir foram preparadas da mesma maneira que a formulação do Exemplo 1, apenas variando a quantidade e/ou seus componentes (Tabela 4) . [0081] The formulations in the following examples were prepared in the same way as the formulation in Example 1, only varying the quantity and/or its components (Table 4).
Tabela 4 Formulações alternativas de acordo com a invenção
Figure imgf000021_0002
Figure imgf000022_0001
Table 4 Alternative formulations according to the invention
Figure imgf000021_0002
Figure imgf000022_0001
[0082] As formulações ora descritas são efetivas na preparação de composições ME, uma vez que não foi observada a formação de cristais . Adicionalmente, ressalta-se que a aparência de todas as composições se manteve como um líquido límpido mesmo quando mantidas durante 14 dias em repouso a[0082] The formulations described here are effective in the preparation of ME compositions, since the formation of crystals was not observed. Additionally, it is noteworthy that the appearance of all compositions remained as a clear liquid even when kept for 14 days at rest at
54°C. 54°C.
EXEMPLO 4 EXAMPLE 4
Tabela 5 Formulações alternativas que compreendem tensoativos não-iônicos não nitrogenados
Figure imgf000022_0002
Table 5 Alternative formulations comprising non-nitrogenized nonionic surfactants
Figure imgf000022_0002
[0083] As formulações acima (Tabela 5) , que não contém os tensoativos não-iônicos nit rogenados dessa invenção, não foram capazes de formar microemulsões , posto que houve formação de cristais, observados pelo turvamento das formulações. [0083] The formulations above (Table 5), which do not contain the nitrogenated non-ionic surfactants of this invention, were not capable of forming microemulsions, as crystals were formed, observed by the cloudiness of the formulations.
EXEMPLO 5 EXAMPLE 5
[0084] O estado de degradação dos ingredientes ativos da composição do EXEMPLO 1 foi analisado a partir de um experimento com HPLC. [0084] The degradation state of the active ingredients in the composition of EXAMPLE 1 was analyzed from an HPLC experiment.
[0085] A amostra de saflufenacil foi analisada pelo método CL6222065, por meio de um detector DAD, em um comprimento de onda 260,4 nm, usando uma coluna Phenomenex Gemini (150 mm x 4,5 mm x 5 µm) LFQ 023, com uma fase móvel acetonitrila filtrada e desgaseificada grau HPLC e água 0,1% ácido fosfórico (70:30), usando um fluxo de 1,0 mL/min, um volume de injeção 5µL, temperatura 40ºC, tempo de retenção ± 2,4 minutos e tempo de corrida 5 minutos. [0086]Para a preparação da solução primária de saflufenacil densidade 1,1524 com concentração de 16,96%, 85,30 mg da solução de saflufenacil foram pesados em um frasco volumétrico de 50 mL. Em seguida, adicionou-se 5 mL de água e acetonitrila foi adicionada até completar 50mL, obtendo-se uma solução com concentração de 1706 mg/L. A solução foi mantida sob agitação até completa dissolução. As soluções foram preparadas em triplicata (Tabela 6). [0087] Para a preparação da solução estoque de saflufenacil 94,19% com concentração de 1076,59 mg/L, 11,43 mg da solução primária foram dissolvidas em acetonitrila até completar 10 mL. [0088] A partir da solução estoque foram preparadas três soluções com 107,66, 301,45 e 506,00 mg/L de saflufenacil, em acetonitrila, as quais foram injetadas no HPLC, de acordo com os parâmetros acima mencionados. [0089] Os resultados demonstraram que a solução inicial com 195,47 g/L de ingrediente ativo, mantido a 25ºC, obteve uma degradação de 2,17%, após ser incubada a 54ºC por 14 dias (FIG. 2 a 7). [0090] Para o cálculo das concentrações das soluções, os seguintes dados foram utilizados (Tabela 6): Tabela 6 – Dados utilizados para o cálculo das concentrações
Figure imgf000023_0001
Figure imgf000024_0001
Concentração % = (CSHPLC / M) * 1000 = 16,96 Concentração g/L = 16,96 * Densidade * 10 = 195,47 [0091] Assim, conforme claramente observado, a composição de acordo com essa invenção, de fato, é uma microemulsão estável de saflufenacil, pois atingiu níveis bastante baixos de degradação, de acordo com a análise realizada no HPLC. [0085] The saflufenacil sample was analyzed by the CL6222065 method, using a DAD detector, in a wavelength 260.4 nm, using a Phenomenex Gemini column (150 mm x 4.5 mm x 5 µm) LFQ 023, with an HPLC grade filtered and degassed acetonitrile mobile phase and water 0.1% phosphoric acid (70:30 ), using a flow rate of 1.0 mL/min, an injection volume of 5µL, temperature 40ºC, retention time ± 2.4 minutes and run time 5 minutes. [0086] To prepare the primary saflufenacil solution density 1.1524 with a concentration of 16.96%, 85.30 mg of the saflufenacil solution were weighed into a 50 mL volumetric flask. Then, 5 mL of water was added and acetonitrile was added until 50 mL, obtaining a solution with a concentration of 1706 mg/L. The solution was kept under stirring until complete dissolution. Solutions were prepared in triplicate (Table 6). [0087] To prepare the stock solution of saflufenacil 94.19% with a concentration of 1076.59 mg/L, 11.43 mg of the primary solution were dissolved in acetonitrile until reaching 10 mL. [0088] From the stock solution, three solutions were prepared with 107.66, 301.45 and 506.00 mg/L of saflufenacil, in acetonitrile, which were injected into the HPLC, according to the parameters mentioned above. [0089] The results demonstrated that the initial solution with 195.47 g/L of active ingredient, kept at 25ºC, achieved a degradation of 2.17%, after being incubated at 54ºC for 14 days (FIG. 2 to 7). [0090] To calculate the concentrations of the solutions, the following data were used (Table 6): Table 6 – Data used to calculate the concentrations
Figure imgf000023_0001
Figure imgf000024_0001
Concentration % = (CS HPLC / M) * 1000 = 16.96 Concentration g/L = 16.96 * Density * 10 = 195.47 [0091] Thus, as clearly observed, the composition according to this invention, in fact , is a stable microemulsion of saflufenacil, as it has reached very low levels of degradation, according to the analysis carried out in HPLC.

Claims

REIVINDICAÇÕES 1. Composição de microemulsão compreendendo saflufenacil, seus sais ou seus N-óxidos, caracterizada por compreender pelo menos um tensoativo não-iônico nitrogenado. 2. Composição, de acordo com a reivindicação 1, caracterizada por compreender (i) saflufenacil, seus sais ou seus N-óxidos, (ii) pelo menos um solvente polar orgânico, (iii) pelo menos um tensoativo não-iônico nitrogenado e (iv) pelo menos um co-tensoativo anfotérico. 3. Composição, de acordo com a reivindicação 1 ou 2, caracterizada por compreender de 15% a 35% do peso total da composição de saflufenacil. 4. Composição, de acordo com qualquer uma das reivindicações 1 a 3, caracterizada pelo referido solvente polar orgânico ser selecionado entre aldeídos, alquilnitrilas, alcanos, amidas, aminas, cetonas, ésteres, nitrilas, hidrocarbonetos substituídos aromáticos, hidrocarbonetos substituídos alifáticos, hidrocarbonetos substituídos cicloalifáticos, hidrocarbonetos halogenados, nitroalcanos, sulfóxidos, sulfonas, seus derivados ou suas misturas; em que preferencialmente o solvente é selecionado entre formilmorfolina, N-formilmorfolina, dimetilacetamida, N,N- dimetilacetamida, dimetilformamida, N,N′- dimetilpropilenoureia, formamida, metilformamida, N- metilformamida, N,N-dimetilformamida, tetrametilureia, N- vinilacetamida, octanamida, N,N-dimetil + decanamida, N,N- dimetil, 2-pirrolidona, N-metilpirrolidona, N- vinilpirrolidona, dimetilsulfóxido, dietilsulfóxido, carbonato de propileno, 4-etil-1,3-dioxolan-2-ona, 4- (metoximetil)-1,3-dioxolan-2-ona, seus derivados ou suas misturas; em que o solvente polar orgânico está presente em uma faixa de 10% a 65% do peso total da composição. 5. Composição, de acordo com qualquer uma das reivindicações 1 a 4, caracterizada pelo referido tensoativo não-iônico nitrogenado ser selecionado entre aminas oxidadas, alquilamidas, alcoóis graxos etoxilados com amina, etoxilados de amina, polímeros de óxido de propileno e óxido de etileno com amina, imidazolina, amidas de ácidos graxos etoxilados, suas misturas ou seus derivados; em que preferencialmente o tensoativo não-iônico nitrogenado é selecionado entre amina de sebo 10 EO, N-óxido de laurilamina, cocamida DEA, laurilamina etoxilada, amina etoxilada de óleo de tálamo, lauramida DEA, amina laurílica etoxilada, amina de soja etoxilada, amina oleílica etoxilada, amina esteárica etoxilada, óxido de dimetil- dodecilamina, óxido de oleildi(2-hidroxietil)amina, óxido de dimetiltetradecilamina, óxido de di(2-hidroxietil)- tetradecilamina, óxido de dimetilhexadecilamina, óxido de beenamina, óxido de cocamina, óxido de deciltetradecilamina, óxido de dihidroxietil C12-C15 alcoxipropilamina, óxido de dihidroxietil cocamina, óxido de di-hidroxietil lauramina, óxido de di-hidroxietil estearamina, óxido de di-hidroxietil lauramina, óxido de amina de palmiste hidrogenado, óxido de sebo de palma hidrogenado, óxido de hidroxietil hidroxipropil C12-C15 alcoxipropilamina, óxido de miristamina, seus derivados ou suas misturas; em que o tensoativo não-iônico nitrogenado está presente em uma faixa de 5% a 50% do peso total da composição. 6. Composição, de acordo com qualquer uma das reivindicações 1 a 5, caracterizada pelo co-tensoativo anfotérico ser selecionado entre betaínas, anfoacetato, sulfobetaína, imidazolina, propianato, acetato, quartenário de amônio, seus derivados e suas misturas; em que preferencialmente o co-tensoativo anfotérico é selecionado entre cocoamidobetaína, lauramidopropil betaína, coco-betaína, ácido de cocoamfoacetato, ácido lauramfoacetato, sulfobetaína e imidazolina, seus derivados ou suas misturas; em que o co-tensoativo anfotérico está presente em uma faixa de 1% a 15% do peso total da composição. 7. Composição, de acordo com qualquer uma das reivindicações 1 a 6, caracterizada por compreender de 0,1% a 25% do peso total da composição de água. 8. Composição, de acordo com qualquer uma das reivindicações 1 a 7, caracterizada por ainda compreender pesticidas adicionais selecionados entre herbicidas pertencentes a classes de inibidores de acetil CoA carboxilase (ACCase), inibidores de HPPD, inibidores de glutamato sintase, inibidores de ácido acetolactato sintase (ALS), inibidores de EPSP sintase, inibidores de síntese de lipídios, inibidores de transporte de auxina, inibidores de ácido graxo de cadeia muito longa, inibidores de biossíntese de carotenoides, inibidores de microtúbulo, inibidores de fotossistema, inibidores de PPO, suas misturas ou derivados; em que preferencialmente o inibidor de ACCase é selecionado entre aloxidima, cletodima, cialofope, clodinafope, diclofope, fenoxaprope, fluazifope, fenoxaprope-P, haloxifope, metamifope, propaquizafope, quizalofope, setoxidima, tepraloxidima, tralcoxidima e pinoxadeno, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de ALS é selecionado entre amidossulfurona, azimsulfurona, bensulfurona, bencarbazona, bispiribaque, clorimurona, cloransulam, ciclossulfamurona, etoxissulfurona, diclosulam, florasulam, flumetsulam, flazassulfurona, flucarbazona, flucetossulfurona, flupirsulfurona, foramsulfurona, halossulfurona, imazossulfurona, ipfencarbazona, mesossulfurona, metazossulfurona, nicossulfurona, ortossulfamurona, oxassulfurona, primissulfurona, propirissulfurona, pirazossulfurona, rimsulfurona, sulfomeclomazoturona, sulfometurona-metila, sulfossulfurona, trifloxissulfurona, clorsulfurona, cinossulfurona, etametsulfurona, iodossulfurona, imazametabenzo, imazamox, imazapique, imazapir, imazaquina, imazetapir, iofensulfurona, metosulam, metsulfurona, penoxsulam, piroxsulam, piritiobaque, piriminobaque, piribenzoxim, pirimissulfano, piriftalida, propoxicarbazona, prossulfurona, tiencarbazona, tifensulfurona, triassulfurona, tribenuron, triflussulfurona, triflussulfurona-metila, tritossulfurona, tiencarbazona, e triafamona, seus derivados, sais e N- óxidos, ou misturas dos mesmos; o inibidor de EPSP sintase é selecionado entre glifosato, sulfosato, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de transporte de auxina é selecionado entre diflufenzopir e naptalam, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de glutamato sintase é selecionado entre glufosinato e bialafós, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de HPPD é selecionado entre benzobiciclona, benzofenape, biciclopirona, fenquinotriona, isoxaclorotol, isoxaflutol, mesotriona, sulcotriona, pirassulfotol, pirazolinato, pirazoxifeno, tefuriltriona, tembotriona, tolpiralato e topramezona, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de síntese de lipídios é selecionado entre butilato, cicloato, eptc, eptam, tiobencarbe, trialato, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de biossíntese de carotenoide é selecionado entre beflubutamida, diflufenicano, fluridona, fluorocloridona, flurtamona picolinafeno, norflurazona, seus derivados, sais e N-óxidos, ou misturas dos mesmos; o inibidor de ácido graxo de cadeia longa é selecionado entre alacloro, acetocloro, anilofós butacloro, cafenstrola, dimetenamida, dimetenamida-P, fenoxassulfona, fentrazamida, flufenaceto, indanofano, metazacloro, metolacloro, mefenaceto, naproanilida, pretilacloro, piroxassulfona, propacloro, S-metolacloro, e tenilcloro, seus derivados, sais e N-óxidos, ou misturas dos mesmos; inibidor de fotossistema é selecionado entre ioxinila, octanoato de ioxinila, bentazona, piridato, bromoxinila, octanoato de bromoxinila, clorotolurona, dimefurona, diurona, linurona, fluometurona, isoproturona, isourona, tebutiurona, benztiazurona, metabenztiazurona, propanila, metobromurona, metoxurona, monolinurona, sidurona, simazina, atrazina, propazina, cianazina, ametrina, simetrina, dimetametrina, prometrina, terbumetona, terbutilazina, terbutrina, trietazina, hexazinona, metamitrona, metribuzina, amicarbazona, bromacila, lenacila, terbacila, cloridazona, desmedifame e fenmedifame. 9. Composição, de acordo com qualquer uma das reivindicações 1 a 8, caracterizada por ainda compreender compostos alquil éster etoxilado do ácido fosfórico, ésteres metílicos ou ésteres metílicos de ácido graxo, complexos metálicos, complexos de compostos inorgânicos ou orgânicos, hidrocarbonetos aromáticos, ácidos graxos insaturados ou saturados, um ou mais compostos básicos, um ou mais ácidos, sais, macro ou micronutrientes, diluentes, sólidos orgânicos ou inorgânicos, agentes de carga, agentes conservantes, agentes antioxidantes, agentes umectantes, agentes dispersantes, transportadores sólidos, agentes de suspensão ou antisedimentação, auxiliadores de absorção ou adsorção, agentes adesivos, agentes desintegrantes, estabilizantes, anticongelantes, anticristalizantes, polímeros ou copolímeros, óleos minerais, vegetais, organosiliconados, solúveis ou insolúveis em água, orgânicos ou inorgânicos, ou suas misturas, em que os referidos componentes estão presentes em uma faixa de 0,01 a 10%, preferencialmente em uma concentração de 0,5% a 5% do peso total da composição. 10. Composição, de acordo com qualquer uma das reivindicações 1 a 9, caracterizada por ainda compreender (v) pelo menos um agente anticristalizante e (vi) pelo menos um agente conservante; em que preferencialmente o pelo menos um agente anticristalizante é selecionado entre copolímeros, polímeros, glicóis, ésteres fosfóricos, ácidos graxos e seus sais, sais solúveis, sacarídeos, polissacarídeos, ésteres de ácidos graxos, aminas, silicones, ésteres de polioxietileno, agentes quelantes, agentes temponantes, seus derivados e suas misturas; mais preferencialmente ainda, o referido pelo menos um agente anticristalizante é selecionado entre copolímero em bloco de óxido de polialquileno, polietilenoglicol, polivinilpirrolidona, etanol, propileno glicol, seus derivados e suas misturas; preferencialmente o referido pelo menos um agente conservante é selecionado entre fenólicos, compostos orgânicos aromáticos, tiazolinas e isotiazolinonas, parabenos, formaldeídos, alcóois, dióis, ácidos, oxidantes, derivados de piridina, ácidos orgânicos, sais de amônio quaternário, aldeídos, seus derivados e suas misturas; mais preferencialmente ainda, o referido pelo menos um agente conservante é selecionado entre di-terc-butil metil fenol (BHT), benzimidazol, metilisotiazolinona, metilcloroisotiazolinona, metilparabeno, propilparabeno, tiabendazol, fenoxietanol, benzisotiazolinona, clorometilisotiazolinona, bronopol (2-bromo-2-nitropropano- 1,3-diol), ácido benzoico, ácido sórbico e seus sais, seus derivados e suas misturas; em que o agente anticristalizante e agente conservante estão presentes na faixa de 0,01 a 10%, preferencialmente de 0,5% a 5% do peso total da composição. 11. Processo de preparação de uma composição, conforme definida na reivindicação 1, caracterizado por compreender as etapas de: a) adicionar o pelo menos um solvente polar orgânico; b) adicionar o pelo menos um tensoativo não-iônico nitrogenado; c) adicionar o pelo menos um co-tensoativo anfotérico; e d) adicionar saflufenacil. 12. Processo, de acordo com a reivindicação 11, caracterizado por ainda compreender as etapas de: a) adicionar o pelo menos um solvente polar orgânico; b) adicionar o pelo menos um tensoativo não-iônico nitrogenado; c) adicionar o pelo menos um co-tensoativo anfotérico; d) adicionar o pelo menos um agente conservante; e) adicionar saflufenacil; e f) adicionar o pelo menos um agente anticristalizante. 13. Processo, de acordo com a reivindicação 11 ou 12, caracterizado por a mistura ser mantida em uma agitação entre 250 a 1000rpm, preferencialmente entre 700 e 800 rpm; o pH da formulação ser mantido entre 5,5 até 8,0; e a temperatura ser mantida entre 5ºC até 40ºC. 14. Processo, de acordo com qualquer uma das reivindicações 11 a 13, caracterizado por na etapa a) serem adicionados pelo menos dois solventes polares orgânicos, em que um solvente orgânico polar é selecionado entre uma amina ou aldeído, e o outro solvente orgânico polar é selecionado entre amidas, numa proporção entre si de 1:1 até 1:2,5; antes da etapa de adição do pelo menos um agente anticristalizante, o referido composto ser previamente fundido; após a adição dos referidos ingredientes a) até d) ou a) até f) ser adicionada água. 15. Processo para o controle de crescimento de plantas indesejáveis, caracterizado por compreender a aplicação da composição, conforme definida na reivindicação 1, às plantas e/ou ao seu habitat, em que o processo compreende o controle de Abutilon theophrasti Medik., Amaranthus ssp., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., e Xanthium strumarium L., incluindo biótipos resistentes a triazina e ALS, e outras pragas agrícolas, especialmente em culturas de soja, legumes, frutas, citros, leguminosas, vegetais, favas, tubérculos, crucíferas, hortaliças, nozes, árvores, ervas, herbáceas, rosas, plantas ornamentais, pastagens, preferencialmente, os cultivos são selecionados entre cebola, abacaxi, amendoim, aspargo, beterraba sacarina, nabo, canola nabo-sueco, couve-chinesa, Camellia sinensis, cártamo, noz-pecã, limão, laranja, café, pepino, capim, cenoura, palma de óleo, morango, algodão, girassol, seringueira, cevada, lúpulo, batata, batata-doce, noz-comum, lentilha, linho, tomate, maçã, mandioca, alfafa, banana, tabaco, oliveira, arroz, feijão-lima, fava, feijão, pinheiro da Noruega, pinheiro, ervilha, damasco, cereja-doce, cereja- ácida, amêndoa, ameixa, pêssego, pera, groselha, mamona, cana-de-açúcar, centeio, sorgo, cacau, trevo-vermelho, trigo comum, trigo duro, uva, milho, ou qualquer outro cultivo que seja afetado por tais plantas indesejáveis. 16. Processo, de acordo com a reivindicação 15, caracterizado pela aplicação ser uma aplicação pré- ou pós- emergência, e pré-plantio incorporado. 17. Uso da composição, conforme definida na reivindicação 1, caracterizado por ser como um herbicida para controlar o crescimento de plantas indesejáveis. CLAIMS 1. Microemulsion composition comprising saflufenacil, its salts or its N-oxides, characterized by comprising at least one nitrogenous non-ionic surfactant. 2. Composition, according to claim 1, characterized by comprising (i) saflufenacil, its salts or its N-oxides, (ii) at least one organic polar solvent, (iii) at least one nitrogenous non-ionic surfactant and ( iv) at least one amphoteric co-surfactant. 3. Composition, according to claim 1 or 2, characterized in that it comprises from 15% to 35% of the total weight of the saflufenacil composition. 4. Composition according to any one of claims 1 to 3, characterized in that said organic polar solvent is selected from aldehydes, alkylnitriles, alkanes, amides, amines, ketones, esters, nitriles, aromatic substituted hydrocarbons, aliphatic substituted hydrocarbons, substituted hydrocarbons cycloaliphatics, halogenated hydrocarbons, nitroalkanes, sulfoxides, sulfones, their derivatives or mixtures thereof; wherein preferably the solvent is selected from formylmorpholine, N-formylmorpholine, dimethylacetamide, N,N-dimethylacetamide, dimethylformamide, N,N′-dimethylpropyleneourea, formamide, methylformamide, N-methylformamide, N,N-dimethylformamide, tetramethylurea, N-vinylacetamide , octanamide, N,N-dimethyl + decanamide, N,N-dimethyl, 2-pyrrolidone, N-methylpyrrolidone, N-vinylpyrrolidone, dimethylsulfoxide, diethylsulfoxide, propylene carbonate, 4-ethyl-1,3-dioxolan-2-one , 4- (methoxymethyl)-1,3-dioxolan-2-one, derivatives thereof or mixtures thereof; wherein the organic polar solvent is present in a range of 10% to 65% of the total weight of the composition. 5. Composition according to any one of claims 1 to 4, characterized in that said nitrogenous non-ionic surfactant is selected from oxidized amines, alkylamides, amine ethoxylated fatty alcohols, amine ethoxylates, propylene oxide polymers and ethylene oxide with amine, imidazoline, ethoxylated fatty acid amides, mixtures thereof or derivatives thereof; wherein preferably the nitrogenous non-ionic surfactant is selected from tallow amine 10 EO, laurylamine N-oxide, cocamide DEA, ethoxylated laurylamine, ethoxylated thalamus oil amine, lauramide DEA, ethoxylated lauryl amine, ethoxylated soy amine, amine ethoxylated oleyl, ethoxylated stearic amine, dimethyldodecylamine oxide, oleyldi(2-hydroxyethyl)amine oxide, dimethyltetradecylamine oxide, di(2-hydroxyethyl)tetradecylamine oxide, dimethylhexadecylamine oxide, behenamine oxide, cocamine oxide, decyltetradecylamine oxide, dihydroxyethyl C 12 -C 15 alkoxypropylamine oxide, dihydroxyethyl cocamine oxide, dihydroxyethyl lauramine oxide, dihydroxyethyl stearamine oxide, dihydroxyethyl lauramine oxide, hydrogenated palm kernel amine oxide, tallow oxide hydrogenated palm oil, hydroxyethyl hydroxypropyl C12-C15 alkoxypropylamine oxide, myristamine oxide, their derivatives or mixtures thereof; wherein the nitrogenous non-ionic surfactant is present in a range of 5% to 50% of the total weight of the composition. 6. Composition, according to any one of claims 1 to 5, characterized in that the amphoteric co-surfactant is selected from betaines, amphoacetate, sulfobetaine, imidazoline, propianate, acetate, ammonium quaternary, their derivatives and their mixtures; wherein preferably the amphoteric co-surfactant is selected from cocoamidobetaine, lauramidopropyl betaine, coco-betaine, cocoamfoacetate acid, lauramfoacetate acid, sulfobetaine and imidazoline, their derivatives or mixtures thereof; wherein the amphoteric co-surfactant is present in a range of 1% to 15% of the total weight of the composition. 7. Composition according to any one of claims 1 to 6, characterized in that it comprises from 0.1% to 25% of the total weight of the composition of water. 8. Composition according to any one of claims 1 to 7, characterized by further comprising additional pesticides selected from herbicides belonging to classes of acetyl CoA carboxylase (ACCase) inhibitors, HPPD inhibitors, glutamate synthase inhibitors, acetolactate acid inhibitors synthase (ALS), EPSP synthase inhibitors, lipid synthesis inhibitors, auxin transport inhibitors, very long chain fatty acid inhibitors, carotenoid biosynthesis inhibitors, microtubule inhibitors, photosystem inhibitors, PPO inhibitors, their mixtures or derivatives; wherein preferably the ACCase inhibitor is selected from aloxidime, clethodime, cialofop, clodinafop, diclofop, fenoxaprop, fluazifop, fenoxaprop-P, haloxyfop, metamifop, propaquizafop, quizalofope, sethoxydime, tepraloxidime, tralkoxidime and pinoxaden, their derivatives, salts and N-oxides, or mixtures thereof; the ALS inhibitor is selected from amidosulfuron, azimsulfuron, bensulfurone, bencarbazone, bispiribaque, chlorimurone, cloransulam, cyclosulfamurone, ethoxysulfuron, diclosulam, florasulam, flumetsulam, flazasulfuron, flucarbazone, flucetosulfuron, flupirsulfuron, foramsulfuron, halosulfuron, , ipfencarbazone, mesosulfuron, metazosulfuron , nicosulfuron, orthosulfamurone, oxasulfuron, primisulfuron, propyrisulfuron, pyrazosulfuron, rimsulfuron, sulfomeclomazoturone, sulfometurone-methyl, sulfosulfuron, trifloxysulfuron, chlorsulfuron, cynosulfuron, etametsulfuron, iodosulfuron, imazamethabenzo, imazamox, ique, imazapyr, imazaquine, imazethapyr, iofensulfuron, metosulam, metsulfuron , penoxsulam, piroxsulam, pyrithiobak, pyriminobaque, pyribenzoxim, pyrimisulfan, pyrifthalide, propoxycarbazone, prosulfuron, thiencarbazone, thifensulfuron, triasulfuron, tribenuron, triflusulfuron, triflusulfuron-methyl, tritosulfuron, thiencarbazone, and triafamone, its derivatives, salts and oxides, or mixtures thereof; the EPSP synthase inhibitor is selected from glyphosate, sulfosate, their derivatives, salts and N-oxides, or mixtures thereof; the auxin transport inhibitor is selected from diflufenzopyr and naptalam, their derivatives, salts and N-oxides, or mixtures thereof; the glutamate synthase inhibitor is selected from glufosinate and bialaphos, their derivatives, salts and N-oxides, or mixtures thereof; the HPPD inhibitor is selected from benzobicyclone, benzofenape, biciclopyrone, phenquinotrione, isoxachlorotol, isoxaflutole, mesotrione, sulcotrione, pyrasulfotol, pyrazolinate, pyrazoxifene, tefuryltrione, tembotrione, tolpiralate and topramezone, their derivatives, salts and N-oxides, or mixtures thereof ; the lipid synthesis inhibitor is selected from butylate, cycloate, eptc, eptam, thiobencarb, triallate, their derivatives, salts and N-oxides, or mixtures thereof; the carotenoid biosynthesis inhibitor is selected from beflubutamide, diflufenican, fluridone, fluorochloridone, flurtamon picolinaphene, norflurazone, their derivatives, salts and N-oxides, or mixtures thereof; the long chain fatty acid inhibitor is selected from alachlor, acetochlor, anilophos butachlor, cafenstrola, dimethenamid, dimethenamid-P, fenoxasulfone, fentrazamide, flufenacet, indanophane, metazachlor, metolachlor, mefenacet, naproanilide, pretylachlor, pyroxasulfone, propachlor, S- metolachlor, and tenylchlor, their derivatives, salts and N-oxides, or mixtures thereof; photosystem inhibitor is selected from ioxynyl, ioxynyl octanoate, bentazone, pyridate, bromoxynyl, bromoxynyl octanoate, chlorotolurone, dimefurone, diuron, linurone, fluometurone, isoproturone, isourone, tebuthiurone, benzthiazurone, metabenzthiazurone, propanyl, metobromurone, methoxurone, monolinurone, sidurone, simazine, atrazine, propazine, cyanazine, ametrine, symethrin, dimethamethrin, promethrin, terbumetone, terbuthylazine, terbutrin, triethazine, hexazinone, metamitrone, metribuzin, amicarbazone, bromacil, lenacil, terbacil, chloridazone, desmedipham and phenmedipham. 9. Composition according to any one of claims 1 to 8, characterized in that it further comprises phosphoric acid ethoxylated alkyl ester compounds, methyl esters or fatty acid methyl esters, metal complexes, complexes of inorganic or organic compounds, aromatic hydrocarbons, acids unsaturated or saturated fatty acids, one or more basic compounds, one or more acids, salts, macro or micronutrients, diluents, organic or inorganic solids, loading agents, preservative agents, antioxidant agents, wetting agents, dispersing agents, solid carriers, suspension or anti-sedimentation agents, absorption or adsorption aids, adhesive agents, disintegrating agents, stabilizers, antifreezes, anticrystallizers, polymers or copolymers, mineral, vegetable, organosilicon oils, soluble or insoluble in water, organic or inorganic, or mixtures thereof, in which the said components are present in a range of 0.01 to 10%, preferably in a concentration of 0.5% to 5% of the total weight of the composition. 10. Composition, according to any one of claims 1 to 9, characterized in that it further comprises (v) at least one anti-crystallizing agent and (vi) at least one preservative agent; wherein preferably the at least one anticrystallizing agent is selected from copolymers, polymers, glycols, phosphoric esters, fatty acids and their salts, soluble salts, saccharides, polysaccharides, fatty acid esters, amines, silicones, polyoxyethylene esters, chelating agents, temponating agents, derivatives thereof and mixtures thereof; more preferably, said at least one anticrystallizing agent is selected from block copolymer of polyalkylene oxide, polyethylene glycol, polyvinylpyrrolidone, ethanol, propylene glycol, derivatives thereof and mixtures thereof; preferably said at least one preservative agent is selected from phenolics, aromatic organic compounds, thiazolines and isothiazolinones, parabens, formaldehydes, alcohols, diols, acids, oxidants, pyridine derivatives, organic acids, quaternary ammonium salts, aldehydes, their derivatives and its mixtures; more preferably, said at least one preservative agent is selected from di-tert-butyl methyl phenol (BHT), benzimidazole, methylisothiazolinone, methylchloroisothiazolinone, methylparaben, propylparaben, thiabendazole, phenoxyethanol, benzisothiazolinone, chloromethylisothiazolinone, bronopol (2-bromo-2 -nitropropane- 1,3-diol), benzoic acid, sorbic acid and their salts, their derivatives and mixtures thereof; wherein the anticrystallizing agent and preservative agent are present in the range of 0.01 to 10%, preferably 0.5% to 5% of the total weight of the composition. 11. Process for preparing a composition, as defined in claim 1, characterized in that it comprises the steps of: a) adding at least one organic polar solvent; b) add at least one nitrogenous non-ionic surfactant; c) adding at least one amphoteric co-surfactant; and d) add saflufenacil. 12. Process, according to claim 11, characterized by further comprising the steps of: a) adding at least one organic polar solvent; b) add at least one nitrogenous non-ionic surfactant; c) adding at least one amphoteric co-surfactant; d) adding at least one preservative agent; e) add saflufenacil; and f) adding the at least one anticrystallizing agent. 13. Process, according to claim 11 or 12, characterized in that the mixture is maintained in agitation between 250 and 1000 rpm, preferably between 700 and 800 rpm; the pH of the formulation is maintained between 5.5 and 8.0; and the temperature is maintained between 5ºC and 40ºC. 14. Process according to any one of claims 11 to 13, characterized in that in step a) at least two polar organic solvents are added, wherein one polar organic solvent is selected from an amine or aldehyde, and the other polar organic solvent is selected from amides, in a ratio of 1:1 to 1:2.5; before the step of adding at least one agent anticrystallizing, said compound being previously melted; after the addition of said ingredients a) to d) or a) to f) water is added. 15. Process for controlling the growth of undesirable plants, characterized in that it comprises applying the composition, as defined in claim 1, to plants and/or their habitat, wherein the process comprises controlling Abutilon theophrasti Medik., Amaranthus ssp ., Ambrosia artemisiifolia L., Ambrosia trifida L., Borreria verticilata, Brachiaria plantaginea, Chamaesyce spp., Capsella bursa-pastoris, Chenopodium album L., Commelina spp., Conyza spp., Digitaria spp., Echinochloa crus-galli, Euphorbia heterophylla, Galinsoga parviflora, Ipomoea spp., Lamium spp., Nicandra physalodes, Polygonum spp., Raphanus raphanistrum, Richardia brasiliensis, Sinapis arvensis, Solanum nigrum, Spermacoce spp., and Xanthium strumarium L., including biotypes resistant to triazine and ALS, and other agricultural pests, especially in soybean crops, legumes, fruits, citrus, legumes, vegetables, broad beans, tubers, crucifers, vegetables, nuts, trees, herbs, herbaceous plants, roses, ornamental plants, pastures, preferably, the crops are selected among onion, pineapple, peanut, asparagus, sugar beet, turnip, canola, Chinese cabbage, Camellia sinensis, safflower, pecan, lemon, orange, coffee, cucumber, grass, carrot, oil palm, strawberry, cotton, sunflower, rubber tree, barley, hops, potato, sweet potato, walnut, lentil, flax, tomato, apple, cassava, alfalfa, banana, tobacco, olive tree, rice, lima bean, broad bean, bean, pine Norwegian, pine, pea, apricot, sweet cherry, sour cherry, almond, plum, peach, pear, currant, castor, sugar cane, rye, sorghum, cocoa, red clover, common wheat, durum wheat , grapes, corn, or any other crop that is affected by such undesirable plants. 16. Process, according to claim 15, characterized in that the application is a pre- or post-emergence application, and pre-planting incorporated. 17. Use of the composition as defined in claim 1, characterized in that it is as a herbicide to control the growth of undesirable plants.
PCT/IB2023/060736 2022-10-20 2023-10-24 Saflufenacil microemulsion composition, method for the preparation thereof and use of same WO2024084471A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BR1020220213780 2022-10-20
BR102022021378A BR102022021378A2 (en) 2022-10-20 2022-10-20 Composition of saflufenacil microemulsion, its preparation process and use
BR1020230209815 2023-10-09
BR102023020981-5A BR102023020981A2 (en) 2023-10-09 2023-10-09 SAFLUFENACIL MICROEMULSION COMPOSITION, ITS PREPARATION PROCESS AND USE

Publications (1)

Publication Number Publication Date
WO2024084471A1 true WO2024084471A1 (en) 2024-04-25

Family

ID=90737233

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2023/060736 WO2024084471A1 (en) 2022-10-20 2023-10-24 Saflufenacil microemulsion composition, method for the preparation thereof and use of same

Country Status (1)

Country Link
WO (1) WO2024084471A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016153913A1 (en) * 2015-03-25 2016-09-29 Huntsman Petrochemical Llc Maleated natural oil derivatives as agrochemical inert ingredients
US20210261494A1 (en) * 2018-06-22 2021-08-26 Basf Se Amino acid based surfactants as formulants for biocides
EP4008185A1 (en) * 2020-12-03 2022-06-08 BASF Agro B.V. Herbicidal composition comprising a saflufenacil microparticles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016153913A1 (en) * 2015-03-25 2016-09-29 Huntsman Petrochemical Llc Maleated natural oil derivatives as agrochemical inert ingredients
US20210261494A1 (en) * 2018-06-22 2021-08-26 Basf Se Amino acid based surfactants as formulants for biocides
EP4008185A1 (en) * 2020-12-03 2022-06-08 BASF Agro B.V. Herbicidal composition comprising a saflufenacil microparticles

Similar Documents

Publication Publication Date Title
JP7358521B2 (en) Use of 3-isoxazolidinone compounds as selective herbicides
JP6906658B2 (en) A herbicidal composition containing 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridin-2-carboxylic acid.
KR102102423B1 (en) Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and certain ps ii inhibitors
RU2632942C2 (en) Herbicidal compositions containing 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-metoxyphenyl) pyridine-2-carboxylic acid or its derivative and dimethoxypirimidine and its derivatives
KR102089384B1 (en) Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid
KR102120793B1 (en) Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid
ES2717034T3 (en) Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid
RU2629256C2 (en) Herbicidal compositions containing 4-amino-3-chloro-5-fluorine-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carbonic acid
RU2632970C2 (en) Herbicidal compositions containing 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-metoxyphenyl)pyridine-2-carboxylic acid
RU2632969C2 (en) Herbicidal compositions containing 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-metoxyphenyl) pyridine-2-carboxylic acid
JP7097366B2 (en) Beflubutamide or a mixture of its optically concentrated form and a second herbicide
UA123991C2 (en) Ternary herbicidal combination comprising saflufenacil
RU2662284C2 (en) Herbicide composition containing 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid, fluoroxypyr and phenoxyauxins
TW201406299A (en) Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and VLCFA synthesis and fatty acid/lipid synthesis inhibiting herbicides
BR102014001759B1 (en) HERBICIDE COMPOSITIONS UNDERSTANDING COMBINATIONS OF 4-AMINO-3-CHLORINE-6- (4-CHLORINE-2-FLUORO-3-METOXYPHENYL) ACID PYRIDINE-2-CARBOXYLIC OR A DERIVATIVE FROM THE SAME AND AN ARYBYLIDE PROPIONATE HYBICIDE METHOD FOR INDESEJABLE VEGETATION CONTROL
RU2720981C2 (en) Complexes based on cloquintocet and amine-based polymers or oligomers
BR102014005580A2 (en) herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or its derivative and insecticides
BR102018016299A2 (en) HERBICIDE COMPOSITIONS UNDERSTANDING 4-AMINO-3-CHLOR-5-FLUORO-6- (4-CHLOR-2-FLUOR-3-METOXYPHENYL) PYRIDINE-2-CARBOXYLIC ACID OR A DERIVATIVE OF THE SAME AND TEMBOTRION AND / OR TOPRAME
WO2024084471A1 (en) Saflufenacil microemulsion composition, method for the preparation thereof and use of same
BR102023020981A2 (en) SAFLUFENACIL MICROEMULSION COMPOSITION, ITS PREPARATION PROCESS AND USE
BR102013032769A2 (en) HERBICIDE COMPOSITIONS UNDERSTANDING OXIFLUORPHEN AND HALOXIFOP
JP6830487B2 (en) A herbicidal composition containing 4-amino-3-chloro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridin-2-carboxylic acid, floraslam and pyroxslam or derivatives thereof.
WO2001085907A2 (en) Herbicidal or plant growth regulatory compositions
WO2024083834A1 (en) A method of controlling weeds
BR112021008350A2 (en) compositions comprising halauxifene and other herbicides and methods thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23879332

Country of ref document: EP

Kind code of ref document: A1