WO2024080457A1 - Dispositif de biocapteur implantable évolutif - Google Patents

Dispositif de biocapteur implantable évolutif Download PDF

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Publication number
WO2024080457A1
WO2024080457A1 PCT/KR2023/001010 KR2023001010W WO2024080457A1 WO 2024080457 A1 WO2024080457 A1 WO 2024080457A1 KR 2023001010 W KR2023001010 W KR 2023001010W WO 2024080457 A1 WO2024080457 A1 WO 2024080457A1
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WO
WIPO (PCT)
Prior art keywords
wireless power
processor
sensor
scalable
biosensor device
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Application number
PCT/KR2023/001010
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English (en)
Korean (ko)
Inventor
이승민
도영락
김서현
진정이
유혜지
Original Assignee
국민대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from KR1020230006896A external-priority patent/KR20240052602A/ko
Application filed by 국민대학교산학협력단 filed Critical 국민대학교산학협력단
Publication of WO2024080457A1 publication Critical patent/WO2024080457A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue

Definitions

  • the present invention relates to an implant chip for sensing biosignals, and more specifically, to a sensor-adaptive biosensor device that includes a general sensor interface and can expand the sensor according to the type of biosignal to be measured.
  • biosensor technology has been developed that can be inserted into animals or the human body to acquire biometric information such as body temperature of animals or people.
  • biometric information such as body temperature of animals or people.
  • technologies are being introduced that can measure biometric information such as body temperature by implanting it directly under the skin tissue of the body, and collect biometric information measured by a bioimplantable sensor through a separate reader or wireless signal.
  • these bioimplantable sensors can be supplied with power for operation through wireless power without a separate battery, and by being implanted in a minimized size, side effects due to implantation can be reduced, and they can also be used for simple biosignal measurement or drug injection. It can be used effectively.
  • One embodiment of the present invention seeks to provide a sensor-adaptive biosensor device that includes a general sensor interface and can expand the sensor according to the type of biosignal to be measured.
  • a scalable implant biosensor device includes an implantable substrate implemented to be implantable into a living body; a memory disposed on the implant substrate and storing the state of sensors in the body; a processor disposed on the implant substrate and generating a wireless power utilization schedule based on the state of the sensor in the body; first and second type sockets disposed on the implant substrate and configured with different physical connection terminals to provide scalable electrical coupling to the processor; and a wireless power controller disposed on the implant substrate and controlling transmission and reception of wireless power so that the processor performs electrical and data communication with a specific body sensor via a specific type of socket according to the wireless power utilization schedule.
  • the implant substrate may be made of a flexible material or a biocompatible material.
  • the processor may detect the release of physical coupling between the first and second type sockets and the body sensor and update the state of the body sensor in conjunction with the memory according to the detection.
  • the processor may regenerate the wireless power utilization schedule when a change in the state of the sensor in the body is detected.
  • the processor sets a virtual communication path through the specific type of socket based on the wireless power utilization schedule, and when the wireless power is received through the wireless power controller, it activates the communication path to communicate with the specific body sensor. It can form a communication channel for electrical and data communication.
  • the processor sets up a virtual preliminary path to connect with other body sensors through a socket of a different type than the specific type socket along with the virtual communication path, and when the amount of wireless power exceeds a preset threshold, the processor
  • the communication channel can be expanded by activating a spare path.
  • the processor collects the minimum power for activating the path based on the activation time and electrically couples with the body sensor coupled to each type of socket. During the ring, average power can be collected for expansion of the communication channel.
  • the wireless power controller When the wireless power controller receives the wireless power from an external power transmission device, it can transmit the wireless power through the communication path.
  • the disclosed technology can have the following effects. However, since it does not mean that a specific embodiment must include all of the following effects or only the following effects, the scope of rights of the disclosed technology should not be understood as being limited thereby.
  • a scalable implant biosensor device can provide a sensor-adaptive biosensor device that includes a general sensor interface and can expand the sensor according to the type of biosignal to be measured.
  • FIG. 1 is a diagram explaining a biosensor system according to the present invention.
  • FIG. 2 is a diagram explaining the functional configuration of the biosensor device of FIG. 1.
  • Figure 3 is a flowchart explaining the process of regenerating the wireless power utilization schedule according to the present invention.
  • Figure 4 is a flowchart explaining the process of forming a communication channel to expand the sensor according to the type of biosignal according to the present invention.
  • Figure 5 is a diagram explaining the architecture of the biosensor device according to the present invention.
  • first and second are used to distinguish one component from another component, and the scope of rights should not be limited by these terms.
  • a first component may be named a second component, and similarly, the second component may also be named a first component.
  • identification codes e.g., a, b, c, etc.
  • the identification codes do not explain the order of each step, and each step clearly follows a specific order in context. Unless specified, events may occur differently from the specified order. That is, each step may occur in the same order as specified, may be performed substantially simultaneously, or may be performed in the opposite order.
  • the present invention can be implemented as computer-readable code on a computer-readable recording medium
  • the computer-readable recording medium includes all types of recording devices that store data that can be read by a computer system.
  • Examples of computer-readable recording media include ROM, RAM, CD-ROM, magnetic tape, floppy disk, and optical data storage devices. Additionally, the computer-readable recording medium can be distributed across computer systems connected to a network, so that computer-readable code can be stored and executed in a distributed manner.
  • FIG. 1 is a diagram explaining a biosensor system according to the present invention.
  • the biosensor system 100 may include a biosensor device 110, a biosignal processing device 130, and a database 150.
  • the biosensor device 110 may correspond to a scalable implant biosensor (bio-sensor) according to the present invention.
  • the biosensor device 110 may be implemented by including an implantable substrate, and main components may be disposed and supported by the implantable substrate.
  • the implant substrate may be made of a flexible material or a biocompatible material, and may be adaptively coupled to changes in biological tissue when implanted in vivo.
  • the biosensor device 110 may be implemented as a terminal device that can be operated by being attached to the user's body or implanted within the body. In one embodiment of the present invention, as shown in FIG. 1, it may be implemented as a single biosensor device 110, but of course, it may be implemented as a plurality of biosensor devices 110 as needed. In this case, each biosensor device 110 may be attached or implanted to different users, and multiple biosensor devices 110 may be attached or implanted to the same user at the same time.
  • biosensor device 110 can be implemented as a device constituting the biosensor system 100 according to the present invention, and the biosensor system 100 can be taken in various forms depending on the purpose of collection according to the type of biosignal. It can be modified and implemented.
  • the biosensor device 110 may be implemented to operate by being wirelessly connected to the biosignal processing device 130, but is not necessarily limited thereto and may be implemented by selectively including various types of sensors.
  • the biosensor device 110 may be implemented including at least one Micro Controller Unit (MCU) to perform independent operations.
  • MCU Micro Controller Unit
  • the bio sensor device 110 can be connected to the bio-signal processing device 130 through a short-range wireless network such as NFC (Near Field Communication) or BT (BlueTooth), and receives a wireless power signal to operate without a separate power device. Can operate independently. Accordingly, when a plurality of biosensor devices 110 are implemented, each biosensor can perform 1:N multi-channel wireless communication with the biosignal processing device 130.
  • a short-range wireless network such as NFC (Near Field Communication) or BT (BlueTooth)
  • BT Bluetooth
  • each biosensor can perform 1:N multi-channel wireless communication with the biosignal processing device 130.
  • the bio-signal processing device 130 may be implemented as a server corresponding to a computer or program that receives bio-signals collected from the user and analyzes them in conjunction with the bio-sensor device 110 according to the present invention. Additionally, the biosignal processing device 130 can be connected to the biosensor device 110 through a wireless network and can transmit and receive data with the biosensor device 110 through the network. Additionally, the biosignal processing device 130 may be implemented to operate in connection with an independent external system (not shown in FIG. 1).
  • the biosignal processing device 130 may be implemented by including a wireless power transfer (WPT) module capable of wirelessly transmitting power to the biosensor device 110.
  • WPT wireless power transfer
  • the wireless power transmission module may be implemented including an antenna to transmit power wirelessly.
  • the wireless power transmission module may include a loop antenna and may further include a reader connected to the loop antenna.
  • the database 150 may correspond to a storage device that stores various information required during the operation of the biosignal processing device 130.
  • the database 150 may store bio-signal information collected from the user, or may store algorithms for bio-signal analysis and information for wireless communication and power, but is not necessarily limited thereto, and is not limited to this, and includes a bio-signal processing device ( 130) can store the collected or processed information in various forms during the process of collecting biological signals through the implant biosensor according to the present invention.
  • the database 150 is shown as a device independent of the biosignal processing device 130, but is not necessarily limited thereto, and may be implemented as a logical storage device included in the biosignal processing device 130. Of course it is possible.
  • FIG. 2 is a diagram explaining the functional configuration of the biosensor device of FIG. 1.
  • the biosensor device 110 may include a socket module 210, a processor 230, a memory 250, and a wireless power controller 270.
  • the socket module 210 may include various types of sockets disposed on an implant substrate and composed of different physical connection terminals to provide scalable electrical coupling to the processor 230. That is, the socket module 210 may include connection terminals for physically connecting various types of sensors, and each connection terminal may be implemented according to the sensor type. Accordingly, multiple sockets can be placed on one implant board.
  • the socket module 210 may include sockets that can be connected to a temperature sensor, PPG sensor, ECG sensor, ECOG sensor, etc.
  • the socket module 210 can provide electrical coupling with various types of sensors in the body, allowing the biosensor device 110 to operate adaptively with various types of sensors.
  • each type of socket constituting the socket module 210 may be placed in different positions depending on the shape or arrangement structure of the substrate.
  • the processor 230 is placed on an implantable substrate and can generate a wireless power utilization schedule based on the state of sensors in the body.
  • the wireless power utilization schedule may correspond to a power usage plan for utilizing the wireless power received by the wireless power controller 270 in the process of collecting and transmitting biological signals through linkage with sensors in the body.
  • the processor 230 can establish and apply a plan in advance to effectively use limited wireless power to expand sensors according to various types of biosignals.
  • the processor 230 can identify in-body sensors connected to each type of socket of the socket module 210 and dynamically adjust the wireless power utilization schedule according to the state of the in-body sensors stored in the memory 250.
  • the processor 230 may detect the release of physical coupling between the first and second type sockets and the body sensor and update the body sensor state in conjunction with the memory 250 according to the detection.
  • the state of the sensor in the body can be classified into an active state and an inactive state based on the connection with each type of socket of the socket module 210, and when the physical connection with the socket module 210 is released, the state of the sensor in the body The sensor state may be updated to a disconnected state.
  • the processor 230 may monitor whether the first and second type sockets are physically coupled to the body sensor in conjunction with the socket module 210. Specifically, the processor 230 can detect the connection or disconnection of physical coupling based on changes in electrical signals transmitted between each type of socket and the sensor in the body.
  • the processor 230 may regenerate the wireless power utilization schedule when a change in the state of a sensor in the body is detected.
  • the processor 230 can detect changes in the body sensor connected to the first and second type sockets of the socket module 210, and schedules wireless power utilization based on the changed body sensor and status information. can be updated.
  • the wireless power utilization schedule updated by the processor 230 can then be loaded by the processor 230 when wireless power is supplied and used in the process of forming a channel for electrical and data communication with a specific body sensor.
  • the processor 230 sets a virtual communication path through a specific type of socket based on the wireless power utilization schedule, and when wireless power is received through the wireless power controller 270, it activates the communication path to communicate with a specific body device.
  • a communication channel can be formed for electrical and data communication with the sensor.
  • the virtual communication path may correspond to the wireless power transmission path, and the electric source of the transmission path may correspond to the wireless power controller 270. That is, the processor 230 can control the wireless power supplied by the wireless power controller 270 to proceed along a communication path formed according to the wireless power utilization schedule.
  • the processor 230 may set up a plurality of communication paths independent of each other according to the wireless power utilization schedule. In this case, the processor 230 may selectively activate any one of the plurality of communication paths. That is, wireless power supplied by the wireless power controller 270 may be transmitted along a currently active communication path among a plurality of communication paths.
  • the processor 230 sets up a virtual preliminary path to connect with other body sensors via a socket of a different type than a specific type socket along with a virtual communication path, and sets the amount of wireless power to a preset threshold. If this is exceeded, the communication channel can be expanded by activating spare paths.
  • the processor 230 may create a plurality of communication paths based on the same wireless power utilization schedule as needed and may assign priority among the plurality of communication paths. Additionally, the processor 230 can create different communication paths that independently pass through each sensor in the body, and can divide a plurality of communication paths into a main path and a spare path according to priority.
  • the processor 230 can control wireless power to be preferentially transmitted along the main path, and if the amount of wireless power provided through the wireless power controller 270 exceeds a preset threshold, reserve power along with the main path. Paths can be activated simultaneously. Accordingly, wireless power can be transmitted simultaneously along the main path and the spare path, and through this, the operation of sensors in the body connected to each path can be controlled.
  • the processor 230 collects the minimum power for activation of the path based on the activation time and connects the virtual path through the first and second type sockets.
  • average power can be collected for expansion of communication channels.
  • the processor 230 can monitor wireless power transmitted along the activated path and collect power information during activation to determine the minimum activated power and average power consumption of each path. That is, the minimum activation power may correspond to the minimum power required for activation of the corresponding path, and the average power consumption may correspond to the average power consumed by the corresponding path during activation.
  • the processor 230 can dynamically adjust whether or not to expand the communication channel according to wireless power based on the minimum power and average power collected for each sensor in the body.
  • the memory 250 is disposed on the implant substrate and can store the state of the sensor in the body. To this end, the memory 250 may be implemented as a built-in memory of the MCU included in the bio sensor device 110. Additionally, data stored in the memory 250 can be accessed by the electrically connected processor 230 and used in the bio-signal processing process according to the present invention.
  • the wireless power controller 270 is placed on the implant board and can control the transmission and reception of wireless power so that the processor 230 performs electrical and data communication with a specific body sensor via a specific type of socket according to the wireless power utilization schedule.
  • the wireless power controller 270 may be implemented including an antenna that transmits and receives wireless power.
  • the antenna may be implemented as a loop-type or coil-type structure considering the size of the biosensor device 110.
  • the wireless power controller 270 may transmit wireless power through a communication path when receiving wireless power from an external power transmission device. That is, the wireless power controller 270 can supply wireless power supplied from the outside along the communication path in conjunction with the processor 230.
  • the external power transmission device may be implemented including a loop antenna of a specific size and may transmit wireless power to the biosensor device 110 through the antenna. That is, the biosensor device 110 can receive wireless power supplied from the outside through the wireless power controller 270 and use it as a power source for sensing biological signals.
  • Figure 3 is a flowchart explaining the process of regenerating the wireless power utilization schedule according to the present invention.
  • the biosensor device 110 can detect the coupling between the socket and the sensor through the processor 230 (step S310). That is, the processor 230 can detect connection and disconnection of physical coupling based on changes in electrical signals between the socket module 210 and the body sensor. If the physical disconnection between the first and second type sockets and the sensor in the body is detected, the processor 230 may update the state of the sensor in the body in conjunction with the memory 250 according to the detection (step S330). .
  • the processor 230 may regenerate the wireless power use schedule according to the change in the state of the sensor in the body (step S350). For example, when the in-body sensor connected to each type of socket of the socket module 210 is changed, the processor 230 can identify the changed in-body sensor and activate the communication channel via the corresponding in-body sensor based on this. For this purpose, a new wireless power utilization schedule can be created. The wireless power utilization schedule can be stored and managed in the memory 250, and the processor 230 can store the newly created wireless power utilization schedule in the memory 250.
  • Figure 4 is a flowchart explaining the process of forming a communication channel to expand the sensor according to the type of biosignal according to the present invention.
  • the biosensor device 110 may set a virtual communication path through a specific type of socket according to the wireless power utilization schedule through the processor 230 (step S410).
  • the processor 230 may independently set a plurality of communication paths according to the same wireless power utilization schedule. That is, an independent communication path can be established for each type of socket included in the socket module 210.
  • the biosensor device 110 can control the transmission and reception of wireless power for electrical and data communication with a specific body sensor through the wireless power controller 270.
  • the biosensor device 110 may activate a communication path according to the wireless power utilization schedule (step S430). If a plurality of communication paths are set by the processor 230, the processor 230 may selectively activate one of the plurality of communication paths.
  • a communication channel for electrical and data communication with a specific sensor in the body can be formed (step S450).
  • the corresponding communication channel may be formed according to a communication path passing through a specific type of socket of the socket module 210, an in-body sensor, the processor 230, the memory 250, and the wireless power controller 270.
  • sensing values measured from sensors in the body can be collected and stored in the memory 250 under the control of the processor 230, and can be stored in the memory 250 through the wireless power controller 270.
  • Data stored in the memory 250 may be wirelessly transmitted to the biosignal processing device 130.
  • Figure 5 is a diagram explaining the architecture of the biosensor device according to the present invention.
  • the biosensor device 110 may be implemented as a biosignal chip including a socket module 210, a processor 230, a memory 250, and a wireless power controller 270.
  • the biosignal chip can be implemented with a bioimplantable flexible material or a biocompatible material, and can be protected through a bioimplantable platform protective coating.
  • the socket module 210 is implemented by including one or more sockets that can be physically coupled to various body sensors 510, thereby providing an expandable interface to a plurality of body sensors.
  • the socket module 210 may include a serial interface or a general purpose input/output port (GPIO).
  • the body sensor 510 connected to the socket module 210 may be implemented in various forms depending on the measurement method and data type.
  • the body sensor 510 may be implemented including two electrodes, a band pass filter, an instrumentation amplifier, and an AD converter (ADC).
  • the body sensor 510 may be implemented including two electrodes, a differential amplifier, a high-pass filter, and a comparator.
  • the processor 230 may be implemented as a CPU, but is of course not limited thereto.
  • the memory 250 may be implemented as an internal memory of the MCU.
  • the wireless power controller 270 may be implemented including an NFC interface and a regulator.
  • socket module 230 processor

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  • Engineering & Computer Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif de biocapteur implantable évolutif comprenant : un substrat implantable conçu pour être bio-implantable ; une mémoire qui est disposée sur le substrat implantable et stocke l'état d'un capteur in vivo ; un processeur qui est disposé sur le substrat implantable et génère un programme d'utilisation de puissance sans fil sur la base de l'état du capteur in vivo ; des prises d'un premier et d'un second type disposées sur le substrat implantable et conçues pour comporter différentes bornes de connexion physique afin de fournir un couplage électrique évolutif au processeur ; et un dispositif de commande de puissance sans fil qui est disposé sur le substrat implantable et commande l'émission et la réception d'une puissance sans fil pour permettre au processeur d'effectuer une communication électrique et de données avec un capteur in vivo spécifique par l'intermédiaire d'une prise d'un type spécifique conformément au programme d'utilisation de puissance sans fil.
PCT/KR2023/001010 2022-10-14 2023-01-20 Dispositif de biocapteur implantable évolutif WO2024080457A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2022-0132306 2022-10-14
KR20220132306 2022-10-14
KR10-2023-0006896 2023-01-17
KR1020230006896A KR20240052602A (ko) 2022-10-14 2023-01-17 스케일 가능한 임플란트 바이오 센서 장치

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007117586A (ja) * 2005-10-31 2007-05-17 Konica Minolta Sensing Inc 生体情報測定装置
KR20200004165A (ko) * 2018-07-03 2020-01-13 광운대학교 산학협력단 복합 생체신호 측정을 위한 멀티센서 기반 유연 패치 장치 및 이를 이용한 복합 생체신호 측정방법
CN112294315A (zh) * 2019-08-02 2021-02-02 华广生技股份有限公司 生理信号监测装置及其传感器支架
WO2021107864A1 (fr) * 2019-11-27 2021-06-03 National University Of Singapore Procédés et systèmes de communication en champ proche
KR20220011238A (ko) * 2020-07-20 2022-01-28 한양대학교 산학협력단 소형 쿼드 밴드 안테나를 이용한 무선 전력 전송 시스템

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007117586A (ja) * 2005-10-31 2007-05-17 Konica Minolta Sensing Inc 生体情報測定装置
KR20200004165A (ko) * 2018-07-03 2020-01-13 광운대학교 산학협력단 복합 생체신호 측정을 위한 멀티센서 기반 유연 패치 장치 및 이를 이용한 복합 생체신호 측정방법
CN112294315A (zh) * 2019-08-02 2021-02-02 华广生技股份有限公司 生理信号监测装置及其传感器支架
WO2021107864A1 (fr) * 2019-11-27 2021-06-03 National University Of Singapore Procédés et systèmes de communication en champ proche
KR20220011238A (ko) * 2020-07-20 2022-01-28 한양대학교 산학협력단 소형 쿼드 밴드 안테나를 이용한 무선 전력 전송 시스템

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