WO2024078286A1

WO2024078286A1 - Gel composition, and preparation and use thereof

Info

Publication number: WO2024078286A1
Application number: PCT/CN2023/120158
Authority: WO
Inventors: 张健
Original assignee: 苏州欧丽特生物医药有限公司
Priority date: 2022-10-13
Filing date: 2023-09-20
Publication date: 2024-04-18
Also published as: CN117883307A

Abstract

Disclosed in the present invention are a gel composition, a related gel, and a preparation method therefor and the use thereof. The gel composition is based on a long-chain N-acyl amino acid, contains no thickener, is transparent/semitransparent in appearance, is mild and non-irritant, and has very good heat resistance and cold resistance. A related gel product is convenient to carry and applicable to various environments and various usage scenarios, and is very easy to rinse off after use. The gel composition provided in the present invention can be applied to a cleaning composition, a washing composition, a cosmetic composition, a skin care composition, a toothpaste composition, etc.

Description

Gel composition and its preparation and application

Technical Field

The present invention relates to the technical field of gel products, and in particular to a gel composition comprising N-long-chain acyl amino acids and basic amino acids/inorganic bases, and related preparation and application in the fields of cosmetics, detergents, toothpastes, etc.

Background technique

Gel-type products are widely used in cosmetics, detergents, toothpaste and other fields because of their clear and transparent/translucent appearance, unique rheological properties, the ability to suspend small particles, a certain degree of ornamental value, and the characteristics of being non-greasy, easy to spread and easy to clean.

At present, gel is mainly formed by adding various polymer thickeners or gelling agents. Common thickeners include cellulose, mucopolysaccharides, polyvinyl alcohol, colloids, sodium polyacrylate, polyvinyl pyrrolidone, vinyl polymers, etc. Common varieties include starch, gelatin, sodium alginate, guar gum, chitosan, gum arabic, xanthan gum, soy protein gum, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, modified paraffin resin, carbomer resin, styrene-butadiene rubber, etc. For AES system, sodium chloride can also be used for thickening.

CN107875037A discloses a skin softening gel containing colored wax, which requires the use of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, and the amount of arginine added in the formula is only 0.2-0.3%, and the arginine is not used to form a gel.

CN106361596A discloses an amino acid foaming cleansing gel, which requires the addition of acrylate cross-linked polymers, hydroxyethyl cellulose, etc. In the surfactant system, hydroxypropyl methylcellulose delays the discharge of water through gelation.

JP2021161104A discloses a gel-like hair cosmetic, which contains polyvinyl pyrrolidone as component (A), diglycerol as component (B), arginine as component (C) and xanthan gum as component (D), wherein the arginine is added to give the hair after application a soft and smooth texture. The purpose is to soften the setting force and suppress peeling, and the added amount is only 0.01 mass % or more and less than 0.3 mass %.

CN104812373A discloses an oral gel for sensitivity and tooth pain, wherein the gel matrix comprises an anionic polymer and a basic amino acid, wherein the anionic polymer comprises cross-linked poly(acrylic acid).

US4010254A discloses a gel based on a vinyl ether-maleic anhydride copolymer neutralized by a basic amino acid. The aqueous solution of the vinyl ether-maleic anhydride copolymer has the property of forming a gel, but the pH value of the aqueous solution is obviously acidic and irritating. The neutralization of the basic amino acid mainly reduces the irritation and does not play a role in the formation of the gel.

JP2004123575A discloses a gel component for external use, which mainly utilizes a water-soluble vinyl polymer as a matrix of an aqueous gel, and a basic amino acid (such as arginine) mainly plays a moisturizing role.

The above documents all adopt the conventional gel formation idea, mainly using polymer thickeners to prepare gels. The amount of basic amino acids added is very small and does not play a gel role. Conventional gel systems still have many problems. For example, in a system with salt, it is sometimes difficult to gel the product with a polymer thickener, and a large amount of water-soluble polymer thickener needs to be added, which has an adverse effect on the functionality of the product and is also detrimental to the user experience such as skin feel. For example, the addition of thickeners/gelling agents sometimes causes discoloration at high temperatures; the foaming properties of surfactants are suppressed; the skin feel is affected by the polymer during cleaning, resulting in false slipperiness, incomplete cleaning, and a strong residual feeling.

CN104105686A discloses a gelling agent, which contains a basic amino acid derivative with the following structure. The gelling agent exerts gelling ability in a water system and can be used in various cosmetics.

CN104114535B discloses a zwitterionic basic amino acid derivative with the following structure, which can also exert gelation ability in water system.

The above-mentioned documents use amino acid derivatives as gelling agents, but they rely on the special structure of amino acid derivatives and are also costly, which is not conducive to large-scale promotion and use.

Amino acid surfactants are mild, low toxic, good biodegradability, good wettability, foaming, antistatic, good compatibility and antibacterial properties. They are widely used in the formulation of daily chemicals such as skin care products, shower gels, facial cleansers, detergents and toothpastes, and can also be used in industries such as biomedicine. When amino acid surfactants are used in the formulation, the preparation of gel products will face greater challenges.

Some research has been conducted on gel products containing amino acid surfactants. For example, EP1505954A1 discloses a strong foam cleansing gel containing an acyl amino acid surfactant, wherein the cosmetic cleansing gel contains: a) water at a concentration of 60 to 90% by weight, b) a thickener at a concentration of 0.1 to 5% by weight, and c) an acyl amino acid surfactant at a concentration of 0.1 to 6% by weight. In order to form the gel, polyacrylate and/or xanthan gum and/or acrylate/alkyl acrylate cross-linked polymer is used as a thickener.

CN1798821A discloses a gel composition comprising N-acylamino acid (A) and at least one oily matrix (B). The N-acylamino acid is added in a very small amount (about 5%) to adjust the touch of the oily matrix.

Although some research has been done, it is still very difficult to thicken the amino acid surfactant system. Related products sometimes have to be used in conjunction with a foaming pump or the amino acid surfactant is not used as the main surfactant, but only as an auxiliary surfactant for traditional petroleum-based surfactants such as fatty alcohol polyoxyethylene ether sulfate (AES), sodium dodecyl sulfate, and sodium dodecylbenzene sulfonate.

The development of high-quality, multifunctional and environmentally friendly surfactants has become the main direction of the surfactant industry. The use of amino acid surfactants to replace traditional petroleum-based surfactants is the trend of industry development. Unilever has announced that it will halve the use of petroleum-based products by 2025 and return the use of petroleum-based products to zero by 2030. Therefore, it is very necessary to solve the problem of preparing corresponding gel products when amino acid surfactants are used as the main surfactant. In particular, gel products can be prepared without using traditional thickeners/gelling agents.

Summary of the invention

In view of this, on one hand, an object of the present invention is to provide a gel composition, wherein the surfactant contained in the composition is mainly an amino acid surfactant.

On the other hand, the present invention provides a gel which is transparent/translucent in appearance, mild and non-irritating, and has very good heat and cold resistance. As a product, it is easy to carry and can be used in various non-home environments such as outdoors; when used, it is very easy to wash.

On the other hand, the present invention aims to provide a preparation method with simple process, low cost and easy industrial production, which can easily obtain a gel product based on an amino acid surfactant.

In a final aspect, the present invention provides a method of imparting gel properties to a cleaning composition.

Specifically, the scheme of the present invention is as follows.

[1] A gel composition comprising (a) an N-long-chain acyl amino acid, (b) a basic amino acid, and (c) water, wherein the gel is formed by self-thickening of the N-long-chain acyl amino acid and the basic amino acid;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, (c) water, and (d) N-long-chain acyl amino acid dipeptide, and forms a gel through self-thickening of the N-long-chain acyl amino acid, the basic amino acid, and the N-long-chain acyl amino acid dipeptide;

Alternatively, the method comprises (a) an N-long-chain acylamino acid, (e) an inorganic base, and (c) water, wherein the gel is formed by self-thickening of the N-long-chain acylamino acid and the inorganic base;

Alternatively, it comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, (c) water, and (d) an N-long-chain acyl amino acid dipeptide, and forms a gel through self-thickening of the N-long-chain acyl amino acid, the inorganic base, and the N-long-chain acyl amino acid dipeptide.

[2] A gel composition comprising (a) an N-long-chain acyl amino acid, (b) a basic amino acid, and (c) water, wherein the weight percentage of the N-long-chain acyl amino acid is greater than 30 wt%, preferably greater than 33 wt%, more preferably greater than 35 wt%, and the weight percentage of the basic amino acid is greater than 15 wt%, preferably greater than 17 wt%, more preferably greater than 20 wt%;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, (c) water, and (d) N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide is greater than 20wt%, preferably greater than 23wt%, and more preferably greater than 20wt%. The weight percentage of basic amino acids is preferably above 25wt%, and the weight percentage of basic amino acids is above 10wt%, preferably above 12wt%, and more preferably above 14wt%;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is above 20wt%, preferably above 23wt%, more preferably above 25wt%, and the molar ratio of N-long-chain acyl amino acid to basic amino acid is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.

[3] A gel composition comprising (a) an N-long-chain acylamino acid, (e) an inorganic base, and (c) water, wherein the weight percentage of the N-long-chain acylamino acid is greater than 40 wt%, preferably greater than 43 wt%, more preferably greater than 45 wt%, and the weight percentage of the inorganic base is greater than 5.5 wt%, preferably greater than 6 wt%, more preferably greater than 6.5 wt%;

Alternatively, it comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, (c) water, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the inorganic base is greater than 4 wt %, preferably greater than 4.5 wt %, more preferably greater than 5 wt %;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (e) inorganic base, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is above 30wt%, preferably above 33wt%, more preferably above 35wt%, and the molar ratio of N-long-chain acyl amino acid to inorganic base is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.

[4] The gel composition according to any one of [1] to [3], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms;

And/or, the amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, lysine, and (methyl)taurine.

[5] The gel composition according to any one of [1] to [4], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

And/or, the amino acid in the N-long-chain acylamino acid is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

[6] According to the gel composition of any one of [1] to [5], the N-long-chain acyl amino acid is selected from one or more of cocoyl alanine, lauroyl alanine, lauroyl sarcosine, cocoyl sarcosine, cocoyl glutamic acid, lauroyl glutamic acid, oleoyl glutamic acid, cocoyl glycine, lauroyl glycine and stearoyl glutamic acid, preferably lauroyl alanine, and particularly preferably N-lauroyl-L-alanine.

[7] The gel composition according to any one of [1] to [6], wherein the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and/or lysine, most preferably arginine;

And/or, the inorganic base is selected from one or more of sodium hydroxide and potassium hydroxide, preferably sodium hydroxide.

[8] The gel composition according to any one of [1] to [7], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms; preferably, the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

And/or, the amino acid in the N-long-chain acyl amino acid dipeptide is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably L-alanine.

[9] According to the gel composition according to any one of [1] to [8], the N-long-chain acyl amino acid dipeptide is selected from one or more of long-chain acyl glycylglycine, long-chain acyl glutamyl glutamate, long-chain acyl alanyl alanine, and long-chain acyl sarcosyl sarcosine.

[10] The gel composition according to any one of [2], [4] to [9], wherein the weight percentage of N-long-chain acylamino acid is less than 55 wt%, preferably less than 50 wt%, and more preferably less than 45 wt%.

[11] The gel composition according to any one of [3] to [9], wherein the N-long-chain acylamino acid is The content percentage is below 75wt%, preferably below 65wt%, and more preferably below 60wt%.

[12] The gel composition according to any one of claims [1] to [11], wherein the weight percentage of the N-long-chain acylamino acid dipeptide is greater than 0.5 wt%, preferably greater than 0.75 wt%, and more preferably greater than 1 wt%;

And/or, the weight ratio of N-long-chain acyl amino acid to N-long-chain acyl amino acid dipeptide is 20:1 to 1.5:1, preferably 15:1 to 3:1, more preferably 10:1 to 6:1.

[13] According to the gel composition described in any one of [1] to [12], the basic amino acid or inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acyl amino acid or N-long-chain acyl amino acid dipeptide, preferably with a neutralization degree of 85% or more, more preferably with a neutralization degree of 88% or 90% or more, and less than 100%; preferably, the neutralization degree is 85%-98%, 88%-96%, more preferably 90%-95%.

[14] The gel composition according to any one of [1] to [13], wherein the composition contains no or substantially no thickener, and preferably contains no thickener at all;

And/or, the composition is free or substantially free of sodium chloride.

[15] According to the gel composition described in [14], the thickener is selected from one or more of cellulose, mucopolysaccharides, polyvinyl alcohols, colloids, sodium polyacrylates, polyvinyl pyrrolidones, and vinyl polymers.

[16] According to any one of items [1] to [15], the pH value of the gel composition is measured by the dilution method specified in GB/T 13531.1, and the pH value is above 4.5, preferably above 5, and more preferably above 5.5; and the pH value is below 12, preferably below 11, and more preferably below 10.

[17] The gel composition according to any one of [1] to [16], after the composition forms a gel, is tested using a Japanese RHEOTECH hardness tester under the test conditions of a load of 2 kg, an adapter of 20 mmφ, a needle penetration speed of 6 cm/min, and a needle penetration distance of 10 mm. The hardness is below 1.80, preferably below 1.50, and more preferably below 1.00.

[18] The gel composition according to any one of [1] to [17], further comprising a water-soluble oil and/or an alkyl glycoside.

[19] The gel composition according to [18], wherein the water-soluble oil is selected from PEG olive oil esters, PEG isostearates, PEG coconut oil esters, PEG avocado esters. One or more; preferably one or more of PEG-10 olive oil glycerides, olive oil PEG-7 esters, olive oil PEG-8 esters, PEG-7 olive oil esters, PEG-15 glyceryl isostearate, PEG-9 coconut oil glycerides, and PEG-11 avocado glycerides.

[20] A gel formed by self-thickening of N-long-chain acylamino acids and basic amino acids;

Alternatively, the self-thickening gel is formed based on N-long-chain acyl amino acids, basic amino acids, and N-long-chain acyl amino acid dipeptides;

Alternatively, the gel is formed based on the self-thickening of N-long-chain acylamino acids and inorganic bases;

Alternatively, the self-thickening gel is formed based on N-long chain acyl amino acids, inorganic bases, and N-long chain acyl amino acid dipeptides.

[21] A gel prepared from the gel composition described in any one of [1] to [19].

[22] The gel according to [20] or [21], wherein the gel is kept at 40±1°C for 24 hours and can be used normally after returning to room temperature;

And/or, the gel is kept at -8±2°C for 24 hours and can be used normally after returning to room temperature.

[23] The gel according to any one of [20] to [22], which is a cleansing gel, a skin care gel, a shampoo gel, a shower gel, a shaving gel, a makeup remover gel, a massage gel, a cosmetic gel, an oral gel or a multi-purpose gel.

[24] Use of the gel composition described in any one of [1] to [19] in a cleaning composition, a detergent composition, a cosmetic composition, a skin care composition or an oral care composition.

[25] A toothpaste comprising the gel composition described in any one of [1] to [19].

[26] A cosmetic comprising the gel composition described in any one of [1] to [19].

[27] A cleaning product comprising the gel composition described in any one of [1] to [19].

[28] A method for preparing the gel composition according to any one of [1] to [19], comprising the following steps:

Mixing (a), (b) or (e), (c) and optionally (d) at 75-90°C, preferably 80-85°C;

Preferably, (b) or (e) is first mixed with (c) to obtain solution I, and then heated at 75-90°C, preferably (a) and optionally (d) are melted at 80-85°C to obtain solution II. Finally, solution I is mixed with solution II at 75-90°C, preferably 80-85°C.

[29] A method for imparting gel properties to a cleaning composition, the cleaning composition comprising (a) an N-long-chain acyl amino acid, and (b) a basic amino acid, wherein the weight percentage of the N-long-chain acyl amino acid is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the basic amino acid is greater than 15 wt %, preferably greater than 17 wt %, more preferably greater than 20 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid, (b) a basic amino acid, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 20 wt %, preferably greater than 23 wt %, more preferably greater than 25 wt %, and the weight percentage of the basic amino acid is greater than 10 wt %, preferably greater than 12 wt %, more preferably greater than 14 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid and (b) a basic amino acid, wherein the weight percentage of the N-long-chain acyl amino acid is above 20 wt %, preferably above 23 wt %, more preferably above 25 wt %, and the molar ratio of the N-long-chain acyl amino acid to the basic amino acid is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.

[30] A method for imparting gel properties to a cleaning composition, the cleaning composition comprising (a) an N-long-chain acylamino acid, and (e) an inorganic base, wherein the weight percentage of the N-long-chain acylamino acid is greater than 40 wt %, preferably greater than 43 wt %, more preferably greater than 45 wt %, and the weight percentage of the inorganic base is greater than 5.5 wt %, preferably greater than 6 wt %, more preferably greater than 6.5 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the inorganic base is greater than 4 wt %, preferably greater than 4.5 wt %, more preferably greater than 5 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid and (e) an inorganic base, wherein the weight percentage of the N-long-chain acyl amino acid is above 30 wt %, preferably above 33 wt %, more preferably above 35 wt %, and the molar ratio of the N-long-chain acyl amino acid to the inorganic base is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.

[31] The method according to [29] or [30], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearyl, styroyl, styroyl, linoleyl, styro ... One or more of fatty acyl, coconut oil fatty acyl, palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, most preferably lauroyl;

[32] The method according to any one of [29] to [31], wherein the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and/or lysine, most preferably arginine;

[33] The method according to any one of [29] to [32], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

And/or, the amino acids in the N-long-chain acyl amino acid dipeptide are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

Preferably, the N-long-chain acyl amino acid dipeptide is selected from one or more of long-chain acyl glycylglycine, long-chain acyl glutamyl glutamate, long-chain acyl alanyl alanine, and long-chain acyl sarcosyl sarcosine.

[34] According to the method described in [29], the weight percentage of N-long-chain acyl amino acid is less than 55wt%, preferably less than 50wt%, and more preferably less than 45wt%.

[35] According to the method described in [30], the weight percentage of N-long-chain acyl amino acid is less than 75wt%, preferably less than 65wt%, and more preferably less than 60wt%.

[36] The method according to any one of [29] to [35], wherein the weight percentage of the N-long-chain acyl amino acid dipeptide is greater than 0.5 wt%, preferably greater than 0.75 wt%, more preferably greater than 1 wt%; and/or the weight ratio of the N-long-chain acyl amino acid to the N-long-chain acyl amino acid dipeptide is from 20:1 to 1.5:1, preferably from 15:1 to 3:1, more preferably from 10:1 to 6:1.

[37] The method according to any one of [29] to [36], wherein the composition does not contain or substantially does not contain and/or, the composition contains no or substantially no sodium chloride.

[38] According to the method described in any one of [29] to [37], the basic amino acid or inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acyl amino acid or N-long-chain acyl amino acid dipeptide, and the degree of neutralization is preferably above 85%, more preferably above 88% and less than 100%.

[39] According to any of the preceding items, the composition consists of (a) N-long-chain acyl amino acid, (b) basic amino acid, (c) water and optionally (d) N-long-chain acyl amino acid dipeptide; or, the composition consists of (a) N-long-chain acyl amino acid, (e) inorganic base, (c) water and optionally (d) N-long-chain acyl amino acid dipeptide; or, the composition consists of (a) N-long-chain acyl amino acid, (b) basic amino acid/(e) inorganic base, (c) water and optionally (d) N-long-chain acyl amino acid dipeptide, a preservative and/or a sweetener.

Compared with the prior art, the present invention has the following beneficial technical effects:

1. The gel composition/gel product of the present invention uses an amino acid surfactant (component (a)) as the main surfactant/only surfactant, especially when compounded with a basic amino acid (component (b)). The product is green, environmentally friendly, non-toxic and harmless, is very gentle and non-irritating to human skin during use, and can reduce dependence on petroleum-based products.

2. The present invention prepares a gel product without using a traditional thickener/gelling agent, thereby avoiding the influence of the thickener/gelling agent on product performance (color, foam, efficacy, use experience, etc.).

3. It was unexpectedly found that the addition of N-long-chain acyl amino acid dipeptide can greatly reduce the amount of raw materials used (i.e., a smaller amount of N-long-chain acyl amino acid can be used to form a gel), and can also improve the heat and cold resistance of the gel to a certain extent, and improve the extrusion and truncation performance of the gel.

4. It was unexpectedly found that when the degree of neutralization is above 85% and less than 100% (i.e., the N-long-chain acyl amino acid/dipeptide is not completely neutralized and the system contains a small amount of N-long-chain acyl amino acid/dipeptide), the amount of raw materials used can be greatly reduced, the gel is softer, and the extrusion and cutting properties of the gel are improved.

5. Gel-state cleaning products are easy to carry and are very suitable for various non-home scenarios such as outdoors and supermarkets.

6. The gel formed by compounding (a) N-long-chain acyl amino acid, (b) basic amino acid and optionally (d) N-long-chain acyl amino acid dipeptide is multifunctional and has very good cleaning power. It can be used as a hand washing product, bath product, shampoo product, makeup remover product, and can also be used as toothpaste. Outdoors, it can be used as a cleaning agent for outdoor tableware, etc.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is the appearance of the gels of Examples 1-7, wherein a to g are the appearance of the gels of Examples 1 to 7, respectively;

FIG2 is the appearance of the gels of Examples 8-10, wherein a to c are the appearance of the gels of Examples 8 to 10 respectively (a is the appearance of the gel of Example 8, b is the appearance of the gel of Example 9, and c is the appearance of the gel of Example 10);

FIG3 is the appearance of the gel of Example 11-12, wherein a is the appearance of the gel of Example 11, and b is the appearance of the gel of Example 12;

FIG4 is the appearance of the gels of Examples 13-15, wherein a to c are the appearance of the gels of Examples 13 to 15, respectively;

FIG5 shows the appearance of the gel of Example 16.

Detailed ways

In one embodiment, a gel composition is provided, comprising (a) N-long-chain acylamino acid, (b) basic amino acid, and (c) water.

For component (a), the N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms. Further, the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl.

The amino acids in the N-long chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, and lysine. Further, the amino acids in the N-long chain acyl amino acids are derived from one or more of alanine, glycine, glutamic acid, sarcosine, One or more of arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

The N-long-chain acyl (methyl) taurine mentioned herein refers to N-long-chain acyl methyl taurine or N-long-chain acyl taurine.

As an example, the N-long-chain acyl amino acid can be selected from cocoyl alanine, lauroyl alanine, cocoyl sarcosine, lauroyl sarcosine, lauroyl glutamic acid, cocoyl glutamic acid, oleoyl glutamic acid, cocoyl glycine, lauroyl glycine, stearoyl glutamic acid, etc., preferably lauroyl alanine, lauroyl sarcosine, especially preferably N-lauroyl-L-alanine. Salts of the relevant N-long-chain acyl amino acids can also be selected as starting materials, and those skilled in the art will understand that there is no essential difference between them and the corresponding acids as starting materials, and they belong to equivalent technical features.

The synthesis process of N-long-chain acylamino acids can refer to the general synthesis method of N-acylamino acid type surfactants, which can be divided into direct method and indirect method. The direct synthesis method of fatty acid raw materials includes enzyme catalytic synthesis and dehydration condensation. The indirect synthesis method includes fatty acid chloride acylation, fatty nitrile hydrolysis acylation, fatty acid anhydride acylation, amide carbonylation reaction, etc. More preferably, it is prepared by the reaction of fatty acid chloride with the amino group of amino acid (Shotten-Baumann condensation reaction or Shotten-Baumann reaction).

A typical preparation process suitable for the present invention is as follows: amino acid and sodium hydroxide are dissolved in water or a mixed solution of water and acetone to obtain an amino acid salt solution; then lauroyl chloride and sodium hydroxide solution are slowly added dropwise to the amino acid salt solution to control the pH of the reaction system, and after the addition is completed, the product is post-treated. Representative methods are disclosed in CN1798821A, US6703517B2, CN102875409B, JPH0570418A, etc.

For the post-treatment of the N-long-chain acyl amino acid product, conventional recrystallization, water washing, drying, etc. can be used. Preferably, the post-treatment comprises the following steps: mixing the crude N-long-chain acyl amino acid with a solvent, optionally stirring, and controlling the temperature T of the mixed system to be above the melting point of the long-chain fatty acid and below the melting point of the N-long-chain acyl amino acid, wherein the solvent is water or an organic solvent or a mixed solution of water and an organic solvent; after the system is temperature controlled, a solid-liquid separation operation is performed. The relevant methods are disclosed by the inventors in CN202210867760.7 and PCT/CN2022/107270, and the relevant contents are introduced here.

For component (b), the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably Arginine and/or lysine are selected, and arginine is most preferred. On the one hand, arginine is beneficial to the heat resistance and cold resistance of the gel product, and the gel is suitable for extrusion; on the other hand, in terms of oral gel, arginine has the ability to promote the deposition of calcium and phosphorus ions on the dentin surface and dentinal tubules, and at the same time has the effect of isolating external stimulation and delaying dentin sensitivity.

For the above components (a) and (b), the basic amino acid salt of N-long-chain acyl amino acid can also be directly added, which is not essentially different from adding components (a) and (b) separately, and is also covered by the scope of protection of the present invention.

Component (c) is not particularly limited. Specifically, ion exchange water, distilled water, purified water, river water, well water, natural water, groundwater, city water, hard water, soft water, etc. can be used. One of these can be used, or two or more selected from the above group can be mixed and used. From the viewpoint of storage stability and sanitation of the product of the present invention, ion exchange water, distilled water, purified water are preferred.

The weight percentage of component (a) N-long-chain acylamino acid used in this embodiment is above 30wt%, preferably above 31wt%, 32wt%, 33wt%, 34wt%, 35wt%. If the amount is too low, it is difficult to obtain a gel. Unless otherwise specified, the weight percentages in the present invention are relative to the composition.

The weight percentage of component (a) N-long-chain acylamino acid is below 55wt%, preferably 54wt%, 53wt%, 52wt%, 51wt%, 50wt%, 49wt%, 48wt%, 47wt%, 46wt%, 45wt%, 44wt%, 43wt%, 42wt%, 41wt%, 40wt% or less. If the dosage is too high, the gel will be too hard, which is not conducive to extrusion and cutting.

The weight percentage of the basic amino acid in component (b) is above 15wt%, preferably above 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%.

In one embodiment, a gel composition is provided. The composition comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is above 20wt%, preferably above 23wt%, and more preferably above 25wt%. Components (a), (b), and (c) refer to the relevant descriptions in other embodiments.

Preferably, the basic amino acid is present in an amount sufficient to partially or completely neutralize the N-long-chain acylamino acid. In a preferred embodiment, the degree of neutralization is above 85%, more preferably above 88%. For example, the degree of neutralization is 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%.

Further, from the perspective of molar ratio, the molar ratio of N-long chain acyl amino acid to basic amino acid is 1: 0.98 to 1: 0.85, preferably 1: 0.96 to 1: 0.88, more preferably 1: 0.95 to 1: 0.90. Exemplarily, when the N-long chain acyl amino acid is 1 mol, the basic amino acid is 0.98, 0.97, 0.96, 0.95, 0.94, 0.93, 0.92, 0.91, 0.90, 0.89, 0.88, 0.87, 0.86 or 0.85 mol.

The present invention surprisingly found that when the degree of neutralization is above 85% and less than 100%, a small amount of unneutralized N-long-chain acyl amino acids and/or N-long-chain acyl amino acid dipeptides are contained in the composition system, which can greatly reduce the amount of raw materials used, make the gel softer, and improve the extrusion and truncation performance of the gel. However, if too much N-long-chain acyl amino acids and/or N-long-chain acyl amino acid dipeptides remain, it will have an adverse effect on the stability of the system, and too much N-long-chain acyl amino acids may gradually precipitate or appear whitening during the use of the product.

In one embodiment, a gel composition is provided, which comprises (a) an N-long-chain acyl amino acid, (b) a basic amino acid, (c) water, and (d) an N-long-chain acyl amino acid dipeptide.

Components (a), (b), and (c) refer to the relevant descriptions in other embodiments, and are not repeated here. Component (d) N-long-chain acyl amino acid dipeptide is a known concept, and long-chain acyl amino acid dipeptide refers to long-chain acylaminoacyl amino acids, typically long-chain acyl glycyl glycine, long-chain acyl glutamyl glutamic acid, long-chain acyl alanyl alanine, long-chain acyl sarcosyl sarcosine, etc., for example, see CN100448968C, PCT/CN2022/107270, etc.

N-long-chain acyl amino acid dipeptide can be prepared from acyl chloride derived from N-long-chain acyl amino acid and amino acid by Schotten-Bowman reaction, etc.; or by reacting amino acid dipeptide such as glutamylglutamic acid with acyl chloride. Preferably, it is obtained by the relevant preparation method disclosed in PCT/CN2022/107270, and the relevant content is introduced here.

The N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

The amino acid in the N-long-chain acyl amino acid dipeptide is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl) taurine, preferably L-alanine. The present invention preferably uses N-long-chain acyl-L-alanine dipeptide, especially lauroyl alanyl alanine.

The introduction of N-long-chain acyl amino acid dipeptide can greatly reduce the amount of raw materials used (i.e., a smaller amount of N-long-chain acyl amino acid can be used to form a gel), and can also improve the heat resistance and cold resistance of the gel to a certain extent, and improve the extrusion and truncation performance of the gel.

Preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide is above 20wt%, preferably above 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%. If the dosage is too low, it is difficult to obtain a gel. The specific amount added is mainly adjusted according to the content of N-long-chain acyl amino acid dipeptide. The higher the content of N-long-chain acyl amino acid dipeptide, the lower the total weight percentage of the corresponding N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide.

The weight percentage of N-long-chain acyl amino acid dipeptide is above 0.5wt%, preferably above 0.75wt%, 1wt%, 1.5wt%, 2wt%.

The weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is 20: 1 to 1.5: 1, preferably 15: 1 to 3: 1, more preferably 10: 1 to 6: 1. The weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is, for example, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3.

The weight percentage of the basic amino acid of component (b) is above 10wt%, preferably above 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%. Preferably, the basic amino acid is present in an amount sufficient to partially or completely neutralize the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide, for example, the amount of basic amino acid added in the aforementioned embodiment can be referred to. When the degree of neutralization is less than 100% and the composition contains the N-long-chain acyl amino acid dipeptide, the amount of raw materials used (referring to the N-long-chain acyl amino acid and dipeptide) can be reduced to a minimum, and the hardness of the product is relatively minimized, which facilitates easier and easier canning of the gel.

In one embodiment, a gel composition is provided, which comprises (a) an N-long-chain acylamino acid, (e) an inorganic base, and (c) water.

Components (a) and (c) refer to the relevant descriptions in other embodiments. Component (e) inorganic base is selected from one or more of sodium hydroxide and potassium hydroxide, preferably sodium hydroxide. Generally speaking, conventional sodium hydroxide can be used without special requirements. If sodium hydroxide solution is used, The dosage refers to the dosage of sodium hydroxide, not the dosage of sodium hydroxide solution.

For the above components (a) and (e), the corresponding salts of N-long-chain acylamino acids may also be directly added, which is not essentially different from adding components (a) and (e) separately, and is also covered by the scope of protection of the present invention.

The weight percentage of component (a) N-long chain acylamino acid is above 40 wt%, preferably above 43 wt%, more preferably above 45 wt%. If the amount is too low, it is difficult to obtain a gel.

The weight percentage of component (a) N-long-chain acylamino acid is below 75wt%, preferably below 70wt%, 68wt%, 65wt%, 64wt%, 63wt%, 62wt%, 61wt%, 60wt%, 59wt%, 58wt%, 57wt%, 56wt%, 55wt%. If the dosage is too high, the gel will be too hard, which is not conducive to extrusion and cutting.

The weight percentage of the inorganic base of component (e) is above 5.5 wt%, preferably above 6 wt%, more preferably above 6.5 wt%. Preferably, the inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acylamino acid.

In one embodiment, a gel composition is provided, which comprises (a) N-long-chain acylamino acid, (e) inorganic base, and (c) water, wherein the weight percentage of the N-long-chain acylamino acid is greater than 30 wt%, preferably greater than 33 wt%, and more preferably greater than 35 wt%.

Preferably, the inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acylamino acid. In a preferred embodiment, the degree of neutralization is above 85%, more preferably above 88%. For example, the degree of neutralization is 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%.

Further, from the perspective of molar ratio, the molar ratio of N-long chain acyl amino acid to inorganic base is 1: 0.98 to 1: 0.85, preferably 1: 0.96 to 1: 0.88, more preferably 1: 0.95 to 1: 0.90. Exemplarily, when the N-long chain acyl amino acid is 1 mol, the inorganic base is 0.98, 0.97, 0.96, 0.95, 0.94, 0.93, 0.92, 0.91, 0.90, 0.89, 0.88, 0.87, 0.86 or 0.85 mol.

The present invention unexpectedly discovered that when the degree of neutralization is above 85% and less than 100%, a small amount of N-long-chain acyl amino acid and/or N-long-chain acyl amino acid dipeptide is contained in the composition system, which can greatly reduce the amount of raw materials used, make the gel softer, and improve the extrusion and cutting performance of the gel.

In one embodiment, a gel composition is provided. The composition comprises (a) N- Long-chain acyl amino acid, (e) inorganic base, (c) water, (d) N-long-chain acyl amino acid dipeptide. Components (a), (e), (c), (d) refer to the relevant descriptions in other embodiments.

The introduction of N-long-chain acyl amino acid dipeptide can greatly reduce the amount of raw materials used (i.e., a smaller amount of N-long-chain acyl amino acid can be used to form a gel), and can also improve the heat and cold resistance of the gel to a certain extent, and improve the extrusion and truncation performance of the gel.

Preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide is above 30wt%, preferably above 31wt%, 32wt%, 33wt%, 34wt%, 35wt%, 36wt%, 37wt%, 38wt%, 39wt%. If the dosage is too low, it is difficult to obtain a gel. The specific amount added is mainly adjusted according to the content of N-long-chain acyl amino acid dipeptide. The higher the content of N-long-chain acyl amino acid dipeptide, the lower the total weight percentage of the corresponding N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide.

The weight percentage of component (e) inorganic base is above 4wt%, preferably above 4.5wt%, more preferably above 5wt%. Preferably, the inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acylamino acid and the N-long-chain acylamino acid dipeptide.

In each implementation manner, if the details not discussed do not conflict with the content, reference can be made to the relevant instructions of other implementation manners.

In various embodiments, the composition of the present invention contains no or substantially no thickener. By “substantially no”, it is meant that the amount of thickener in the composition does not significantly affect the performance of the product, and the amount of thickener is insufficient to form a gel, i.e., the gel formation of the present invention is not due to the action of the thickener. Preferably, the composition of the present invention does not contain any traditional thickener at all. As described in the technical specification, traditional thickeners/gelling agents have adverse effects on product performance (color, foam, efficacy, user experience, etc.).

Furthermore, the composition of the present invention does not contain thickeners such as cellulose, mucopolysaccharides, polyvinyl alcohols, colloids, sodium polyacrylates, polyvinyl pyrrolidones, vinyl polymers, etc. For example, the composition of the present invention does not contain starch, gelatin, sodium alginate, guar gum, chitosan, gum arabic, xanthan gum, soy protein gum, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, modified paraffin resin, carbomer resin, styrene-butadiene rubber, etc.

Furthermore, the composition of the present invention does not involve an AES system and does not require sodium chloride thickening, so the composition does not contain or substantially contains no sodium chloride. The so-called "substantially contains no" means that the amount of sodium chloride in the composition will not significantly affect the performance of the product, and the amount of sodium chloride is insufficient to form a gel.

In various embodiments, the pH value of the gel composition of the present invention falls within the range of weak acidity to weak alkalinity, which is advantageous for application. Specifically, the pH value of the gel composition is measured by the dilution method specified in GB/T 13531.1, and the pH value is above 4.5, preferably above 5, and more preferably above 5.5; and the pH value is below 12, preferably below 11, and more preferably below 10.

In each embodiment, after the gel composition of the present invention forms a gel, the hardness is tested by a Japanese RHEOTECH hardness tester under the test conditions of a load of 2 kg, an adapter of 20 mmφ, a needle penetration speed of 6 cm/min, and a needle penetration distance of 10 mm. The hardness is below 1.80, preferably below 1.70, 1.60, 1.50, 1.40, 1.30, 1.20, 1.10 or 1.00, and more preferably below 0.90, 0.80, 0.70, 0.50, 0.40, 0.30 or 0.20. The lower the gel hardness, the more conducive it is to filling of tubular products.

The present invention also provides a gel, which is prepared from the above-mentioned gel composition. Preferably, the gel of the present invention has good heat resistance and cold resistance. Specifically, the gel is kept at 40±1°C for 24 hours and can be used normally after returning to room temperature; the gel is kept at -8±2°C for 24 hours and can be used normally after returning to room temperature. The "can be used normally" means that the appearance and performance of the gel have no obvious changes and do not affect the use.

The gel of the present invention can be used as a cleansing gel, a skin care gel, a shampoo gel, a shaving gel, a makeup removal gel, a massage gel, a cosmetic gel, an oral gel or a multifunctional gel. The multifunctionality means that it can be used in a variety of scenarios and has a variety of uses. For example, it can be used as a hand washing product, a bath product, a shampoo product, a makeup removal product, or a multifunctional gel. It can be used as toothpaste; outdoors, it can be used as a cleaner for various utensils such as outdoor tableware.

The present invention also provides a toothpaste containing the aforementioned gel composition. As a toothpaste product, abrasives, moisturizers, sweeteners, flavors, preservatives, colorants, etc. may also be added according to the requirements of product performance.

The present invention also provides a cosmetic comprising the aforementioned gel composition. As a cosmetic product, moisturizers, flavors, preservatives, colorants, oils, suspended particles, etc. may also be added according to the requirements of product performance. The suspended particles are selected from oil-insoluble solid particles or oil-immiscible liquids. The oil-insoluble solid particles include mica, starch, zinc oxide, titanium dioxide, talc and silicone elastomer. The oil-immiscible liquid includes glycerin, water and polyols.

The present invention also provides a cleaning product, which contains the aforementioned gel composition. As the cleaning product, softeners, chelating agents, preservatives, glycerin and essences can also be added according to the requirements of product performance.

The present invention also provides a cleaning product with a minimal formula, which contains only the aforementioned (a) N-long-chain acyl amino acid, (b) basic amino acid/(e) inorganic base, and (c) water. Alternatively, it contains only the aforementioned (a) N-long-chain acyl amino acid, (b) basic amino acid/(e) inorganic base, (c) water and necessary preservatives and/or sweeteners.

The present invention provides a method for preparing a gel composition, comprising the following steps: mixing (a), (b) or (e), (c) and optionally (d) at 75-90°C, preferably 80-85°C.

Preferably, (b) or (e) is first mixed with (c) to obtain solution I, then (a) and optional (d) are melted at 75-90°C, preferably 80-85°C to obtain solution II, and finally, solution I is mixed with solution II at 75-90°C, preferably 80-85°C.

The present invention also provides a method for imparting gel properties to a cleaning composition, the cleaning composition comprising (a) an N-long-chain acyl amino acid, and (b) a basic amino acid, wherein the weight percentage of the N-long-chain acyl amino acid is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the basic amino acid is greater than 15 wt %, preferably greater than 17 wt %, more preferably greater than 20 wt %;

Alternatively, the invention comprises (a) an N-long chain acyl amino acid, (b) a basic amino acid, and (d) an N-long chain acyl amino acid dipeptide, wherein the N-long chain acyl amino acid and the N-long chain acyl amino acid dipeptide The total weight percentage of is more than 20wt%, preferably more than 23wt%, more preferably more than 25wt%, the weight percentage of basic amino acids is more than 10wt%, preferably more than 12wt%, more preferably more than 14wt%;

Components (a), (b), (d) and their amounts are as described in other embodiments. When the above components are used, gel properties can be imparted to the cleaning composition.

The present invention also provides another method for imparting gel properties to a cleaning composition, the cleaning composition comprising (a) an N-long-chain acylamino acid, and (e) an inorganic base, wherein the weight percentage of the N-long-chain acylamino acid is greater than 40 wt %, preferably greater than 43 wt %, more preferably greater than 45 wt %, and the weight percentage of the inorganic base is greater than 5.5 wt %, preferably greater than 6 wt %, more preferably greater than 6.5 wt %;

Alternatively, it comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the inorganic base is greater than 4 wt %, preferably greater than 4.5 wt %, more preferably greater than 5 wt %;

Components (a), (e), (d) and their usage amounts refer to the related descriptions in other embodiments. When the above components are used, gel properties can be imparted to the cleaning composition.

The present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. In addition, it should be understood that after reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalents also fall within the scope of the claims attached to this application. A certain range.

The present invention will be further described below with reference to specific embodiments.

Example

Mix basic amino acid or sodium hydroxide with water to obtain solution I; melt N-long chain acyl amino acid (N-long chain acyl amino acid dipeptide) at 85°C to obtain solution II; finally, gradually add solution I to solution II at 85°C while stirring to finally form a gel (some embodiments are solutions), which is recorded in detail in Table 1. The appearance of the gels of Examples 1-7 is shown in Figure 1; the appearance of the gels of Examples 8-10 is shown in Figure 2; the appearance of the gels of Examples 11-12 is shown in Figure 3; the appearance of the gels of Examples 13-15 is shown in Figure 4; the appearance of the gel of Example 16 is shown in Figure 5.

As shown in FIG1 , when the weight percentage of N-lauroyl-L-alanine reaches 30wt%, gel begins to appear. As the content of N-lauroyl-L-alanine increases, the amount of gel gradually increases. When the content reaches 33wt%, all the solutions become gel.

As shown in Figure 2, if arginine is replaced with sodium hydroxide, when the weight percentage of N-lauroyl-L-alanine is 35wt%, the product is still a solution; when the weight percentage of N-lauroyl-L-alanine is 40wt%, most of it forms a gel, with only a small amount of solution; further increasing the content of N-lauroyl-L-alanine, all of it forms a gel.

As shown in FIG3 , if N-lauroyl-L-alanine is replaced by lauroyl sarcosine, gel begins to appear when the weight percentage of lauroyl sarcosine is 33 wt %, and gel is completely formed when the content is increased to 35%.

As shown in FIG4 , if arginine is replaced by lysine, a gel can also be formed.

As shown in FIG5 , if lauroyl alanyl alanine (lauroyl alanine dipeptide) is further introduced, a gel can be formed when the total content of N-lauroyl-L-alanine and dipeptide is 25 wt %.

Further research found that when the degree of neutralization is above 85% and less than 100%, the amount of long-chain acyl amino acids used can also be greatly reduced, and the gel is softer (see Examples 17-23). When a small amount of dipeptide is added and incompletely neutralized (Example 20), the amount of long-chain acyl amino acids added can be further reduced.

Table 1.

*1. Prepared by reacting sodium lauroyl sarcosinate aqueous solution with hydrochloric acid.
*2. Prepared by reacting lysine hydrochloride aqueous solution with sodium hydroxide.
*3.Dipeptide refers to lauroyl alanine, "N-lauroyl-L-alanine + dipeptide" refers to
Prepared by the method of Example 503# and Example 6 of PCT/CN2022/107270.
*4. In Example (VI), except for N-lauroyl-L-alanine and arginine, the balance is water, and the molar ratio refers to N-
Lauroyl-L-Alanine:Arginine.
*5. The composition of the long-chain acyl amino acid in Example 20 is: 95% N-lauroyl-L-alanine + 5% lauroyl alanine dipeptide.

Performance Evaluation

Touch: 3 professional reviewers evaluated separately and made comprehensive judgment.

Hardness: Test instrument: Japan RHEOTECH hardness tester/rheometer, test conditions: load 2kg (select 2K/20N), adapter 20mmφ, needle penetration speed 6cm/min, needle penetration distance 10mm.

pH: Measure the pH value of the solution obtained by the dilution method specified in GB/T 13531.1.

Heat resistance test: maintain at 40℃ for 24h, 60℃, 70℃, 80℃ for 1h respectively, then return to room temperature to observe the stability of the gel under high temperature conditions and whether it can be used normally after returning to room temperature.

Cold resistance test: keep at -6℃ for 24h, keep at -18℃ for 12h, then return to room temperature to observe the stability of the gel under low temperature conditions and whether it can be used normally after returning to room temperature.

Stability test: -6℃, 50℃, cycle test, light resistance test were performed for one month and then stopped for observation. Cycle test: 0℃×2 days→25℃×2 days→40℃×2 days cycle; light resistance test: fluorescent light irradiation conditions: about 23000Lux/day, 25℃.

Observe for 3 months at 40℃, 3 months at 5℃, and 3 months at room temperature.

The test results are recorded in Table 2.

Table 2.

-: Not tested ◎: The gel is very stable and can be used normally after returning to room temperature. The recovery speed is fast ○: The gel is stable and can be used normally after returning to room temperature. The recovery speed is fast △: The gel is not very stable. The morphology changes after returning to room temperature, and the performance is different ×: The gel is unstable and cannot be used normally after returning to room temperature

Judging from the comprehensive results of the experiment, the combination of N-long-chain acyl amino acids and arginine has very good stability. Among them, the combination of N-lauroyl-L-alanine and arginine performs well in heat resistance, cold resistance, stability, and excellent cleaning power; the combination of lauroyl sarcosine and arginine performs well in heat resistance, cold resistance, and stability, but lacks cleaning power.

The combination of N-lauroyl-L-alanine and lysine has poor stability (especially low temperature stability); the combination of N-lauroyl-L-alanine and sodium hydroxide has moderate stability.

The combination of N-lauroyl-L-alanine, lauroyl alanyl alanine (dipeptide) and arginine has the best performance. On the one hand, the product has excellent performance in heat resistance, cold resistance and stability; on the other hand, its high cleaning power is conducive to use in various scenarios.

Further research found that when the degree of neutralization is above 85% and less than 100%, the gel formed is very soft and more suitable for filling tubular products. When the degree of neutralization is low (such as below 85%), it is found that whitening sometimes occurs in the heat and cold cycle test (it may be that the excessive unneutralized lauroyl alanine will gradually precipitate). When a small amount of dipeptide is added and not completely neutralized (Example 20), a stable soft gel can be formed using about 25% of long-chain acyl amino acids.

In addition, those skilled in the art will appreciate that, although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present invention and form different embodiments. For example, in the following claims, any one of the claimed embodiments may be used in any combination.

Claims

A gel composition, characterized in that it comprises (a) an N-long chain acyl amino acid, (b) a basic amino acid, and (c) water, and forms a gel through self-thickening of the N-long chain acyl amino acid and the basic amino acid;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, (c) water, and (d) N-long-chain acyl amino acid dipeptide, and forms a gel through self-thickening of the N-long-chain acyl amino acid, the basic amino acid, and the N-long-chain acyl amino acid dipeptide;

Alternatively, the method comprises (a) an N-long-chain acylamino acid, (e) an inorganic base, and (c) water, wherein the gel is formed by self-thickening of the N-long-chain acylamino acid and the inorganic base;

Alternatively, it comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, (c) water, and (d) an N-long-chain acyl amino acid dipeptide, and forms a gel through self-thickening of the N-long-chain acyl amino acid, the inorganic base, and the N-long-chain acyl amino acid dipeptide.
A gel composition, characterized in that it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is greater than 30 wt%, preferably greater than 33 wt%, more preferably greater than 35 wt%, and the weight percentage of basic amino acid is greater than 15 wt%, preferably greater than 17 wt%, more preferably greater than 20 wt%;

Alternatively, it comprises (a) an N-long-chain acyl amino acid, (b) a basic amino acid, (c) water, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 20 wt%, preferably greater than 23 wt%, more preferably greater than 25 wt%, and the weight percentage of the basic amino acid is greater than 10 wt%, preferably greater than 12 wt%, more preferably greater than 14 wt%;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (b) basic amino acid, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is above 20wt%, preferably above 23wt%, more preferably above 25wt%, and the molar ratio of N-long-chain acyl amino acid to basic amino acid is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.
A gel composition, characterized in that it comprises (a) N-long-chain acylamino acid, (e) inorganic base, and (c) water, wherein the weight percentage of the N-long-chain acylamino acid is above 40wt%, preferably above 43wt%, more preferably above 45wt%, and the weight percentage of the inorganic base is above 5.5wt% or more, preferably 6wt% or more, more preferably 6.5wt% or more;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (e) inorganic base, (c) water, and (d) N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide is greater than 30wt%, preferably greater than 33wt%, more preferably greater than 35wt%, and the weight percentage of inorganic base is greater than 4wt%, preferably greater than 4.5wt%, more preferably greater than 5wt%;

Alternatively, it comprises (a) N-long-chain acyl amino acid, (e) inorganic base, and (c) water, wherein the weight percentage of N-long-chain acyl amino acid is above 30wt%, preferably above 33wt%, more preferably above 35wt%, and the molar ratio of N-long-chain acyl amino acid to inorganic base is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.
The gel composition according to any one of claims 1 to 3, characterized in that the N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms;

And/or, the amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, lysine, and (methyl)taurine.
The gel composition according to any one of claims 1 to 4, characterized in that the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

And/or, the amino acid in the N-long-chain acylamino acid is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.
The gel composition according to any one of claims 1 to 5, characterized in that the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and/or lysine, most preferably arginine;

And/or, the inorganic base is selected from one or more of sodium hydroxide and potassium hydroxide.
The gel composition according to any one of claims 1 to 6, characterized in that the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

And/or, the amino acids in the N-long-chain acyl amino acid dipeptide are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.
The gel composition according to any one of claims 1 to 7, characterized in that the N-long-chain acyl amino acid dipeptide is selected from one or more of long-chain acyl glycylglycine, long-chain acyl glutamyl glutamate, long-chain acyl alanyl alanine, and long-chain acyl sarcosyl sarcosine.
The gel composition according to any one of claims 2, 4-8, characterized in that the weight percentage of N-long-chain acylamino acid is below 55wt%, preferably below 50wt%, and more preferably below 45wt%.
The gel composition according to any one of claims 3 to 8, characterized in that the weight percentage of the N-long-chain acylamino acid is below 75 wt%, preferably below 65 wt%, and more preferably below 60 wt%.
The gel composition according to any one of claims 1 to 10, characterized in that the weight percentage of the N-long-chain acyl amino acid dipeptide in the composition is above 0.5 wt%, preferably above 0.75 wt%, and more preferably above 1 wt%;

And/or, the weight ratio of N-long-chain acyl amino acid to N-long-chain acyl amino acid dipeptide is 20:1 to 1.5:1, preferably 15:1 to 3:1, more preferably 10:1 to 6:1.
The gel composition according to any one of claims 1 to 11, characterized in that the basic amino acid or inorganic base is present in an amount sufficient to partially or completely neutralize the N-long-chain acyl amino acid or N-long-chain acyl amino acid dipeptide, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 100%.
The gel composition according to any one of claims 1 to 12, characterized in that the composition does not contain or substantially does not contain a thickener;

And/or, the composition is free or substantially free of sodium chloride.
The gel composition according to claim 13, characterized in that the thickener is selected from one or more of cellulose, mucopolysaccharides, polyvinyl alcohols, colloids, sodium polyacrylates, polyvinyl pyrrolidones, and vinyl polymers.
The gel composition according to any one of claims 1 to 14 is characterized in that, when the pH value of the gel composition is measured by the dilution method specified in GB/T 13531.1, the pH value is above 4.5, preferably above 5, more preferably above 5.5; and the pH value is below 13, preferably below 11, more preferably below 10.
The gel composition according to any one of claims 1 to 15, characterized in that after the composition forms a gel, the hardness is tested by a Japanese RHEOTECH hardness tester under the test conditions of a load of 2 kg, an adapter of 20 mmφ, a needle penetration speed of 6 cm/min, and a needle penetration distance of 10 mm, and is below 1.80, preferably below 1.50, and more preferably below 1.00.
The gel composition according to any one of claims 1 to 16, characterized in that the composition further comprises water-soluble oils and/or alkyl glycosides.
The gel composition according to claim 17, characterized in that the water-soluble oil is selected from one or more of PEG olive oil esters, PEG isostearates, PEG coconut oil esters, and PEG avocado esters; preferably one or more of PEG-10 olive oil glycerides, olive oil PEG-7 esters, olive oil PEG-8 esters, PEG-7 olive oil esters, PEG-15 glyceryl isostearate, PEG-9 coconut oil glycerides, and PEG-11 avocado glycerides.
A gel characterized by being formed by self-thickening based on N-long-chain acylamino acids and basic amino acids;

Alternatively, the self-thickening formation is based on N-long chain acyl amino acids, basic amino acids, and N-long chain acyl amino acid dipeptides;

Alternatively, it is formed by self-thickening based on N-long-chain acylamino acids and inorganic bases;

Alternatively, it can be formed by self-thickening based on N-long chain acyl amino acids, inorganic bases, or N-long chain acyl amino acid dipeptides.
A gel, characterized in that it is prepared from the gel composition according to any one of claims 1 to 18.
The gel according to claim 19 or 20, characterized in that the gel is kept at 40±1°C for 24 hours and can be used normally after returning to room temperature;

And/or, the gel is kept at -8±2°C for 24 hours and can be used normally after returning to room temperature.
The gel according to any one of claims 19 to 21, characterized in that the gel is a cleaning gel, a skin care gel, a shampoo gel, a shower gel, a shaving gel, a makeup remover gel, a massage gel, a cosmetic gel, an oral gel or a multifunctional gel.
Use of the gel composition according to any one of claims 1 to 18, characterized in that it is used in a cleaning composition, a washing composition, a cosmetic composition, a skin care composition or an oral care composition.
A toothpaste, characterized in that it contains the gel composition according to any one of claims 1 to 18.
A cosmetic, characterized in that it contains the gel composition according to any one of claims 1 to 18.
A cleaning product, characterized in that it contains the gel composition according to any one of claims 1 to 18.
A method for preparing the gel composition according to any one of claims 1 to 18, characterized in that it comprises the following steps:

Mixing components (a) N-long-chain acyl amino acid, (b) basic amino acid or (e) inorganic base, (c) water and optionally (d) N-long-chain acyl amino acid dipeptide at 75-90° C., preferably 80-85° C.;

Preferably, components (b) or (e) and (c) are first mixed to obtain solution I, and then (a) and optional (d) are melted at 75-90°C, preferably 80-85°C to obtain solution II. Finally, solution I is mixed with solution II at 75-90°C, preferably 80-85°C.
A method for imparting gel properties to a cleaning composition, characterized in that the cleaning composition comprises (a) an N-long chain acyl amino acid, and (b) a basic amino acid, wherein the weight percentage of the N-long chain acyl amino acid is greater than 30 wt %, preferably greater than 33 wt %, and more preferably greater than 35 wt %; the weight percentage of the basic amino acid is greater than 15 wt %, preferably greater than 17 wt %, and more preferably greater than 18 wt %. 20wt% or more;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid, (b) a basic amino acid, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 20 wt %, preferably greater than 23 wt %, more preferably greater than 25 wt %, and the weight percentage of the basic amino acid is greater than 10 wt %, preferably greater than 12 wt %, more preferably greater than 14 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid and (b) a basic amino acid, wherein the weight percentage of the N-long-chain acyl amino acid is above 20 wt %, preferably above 23 wt %, more preferably above 25 wt %, and the molar ratio of the N-long-chain acyl amino acid to the basic amino acid is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.
A method for imparting gel properties to a cleaning composition, characterized in that the cleaning composition comprises (a) an N-long-chain acylamino acid, and (e) an inorganic base, wherein the weight percentage of the N-long-chain acylamino acid is greater than 40 wt%, preferably greater than 43 wt%, more preferably greater than 45 wt%, and the weight percentage of the inorganic base is greater than 5.5 wt%, preferably greater than 6 wt%, more preferably greater than 6.5 wt%;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid, (e) an inorganic base, and (d) an N-long-chain acyl amino acid dipeptide, wherein the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide is greater than 30 wt %, preferably greater than 33 wt %, more preferably greater than 35 wt %, and the weight percentage of the inorganic base is greater than 4 wt %, preferably greater than 4.5 wt %, more preferably greater than 5 wt %;

Alternatively, the cleaning composition comprises (a) an N-long-chain acyl amino acid and (e) an inorganic base, wherein the weight percentage of the N-long-chain acyl amino acid is above 30 wt %, preferably above 33 wt %, more preferably above 35 wt %, and the molar ratio of the N-long-chain acyl amino acid to the inorganic base is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90.