WO2024073392A1 - Utilisation d'antimicrobiens non volatils dans un emballage alimentaire - Google Patents

Utilisation d'antimicrobiens non volatils dans un emballage alimentaire Download PDF

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Publication number
WO2024073392A1
WO2024073392A1 PCT/US2023/075093 US2023075093W WO2024073392A1 WO 2024073392 A1 WO2024073392 A1 WO 2024073392A1 US 2023075093 W US2023075093 W US 2023075093W WO 2024073392 A1 WO2024073392 A1 WO 2024073392A1
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salt
food preservation
composition
preservation composition
antimicrobial agent
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PCT/US2023/075093
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English (en)
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WO2024073392A4 (fr
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Michael A. Johnston
Angela Morgan
Kareen Nguyen HUYNH
Sasha Gaye BUCKMASTER
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Csp Technologies, Inc.
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Publication of WO2024073392A1 publication Critical patent/WO2024073392A1/fr
Publication of WO2024073392A4 publication Critical patent/WO2024073392A4/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof

Definitions

  • the disclosed concept relates generally to the use of nonvolatile antimicrobials in packaging for foodstuffs.
  • Food products such as fresh meat, poultry, fruit, and vegetables are typically stored and sold in a supporting tray that is overwrapped by a transparent plastic film, enabling visual inspection of the food products.
  • These food products generally produce an exudate (i.e., juices), which can be a source for the growth of microbial agents.
  • the prevention of microbial agent growth improves food safety and preserves its quality, as a well as prolonging the freshness of the food product.
  • an absorbent pad is placed in the supporting tray.
  • the simplest type of absorbent pad for absorbing food product fluids is composed of a bundle of sheets of absorbent paper with or without a sheet of plastic film below the bundle. Another sheet of plastic film may also be placed over the bundle of paper sheets.
  • One or both of the sheets of plastic film typically are perforated or are otherwise fluid pervious.
  • a disadvantage of absorbent pads is that the pads have a low absorbency and do not retain moisture under pressure. In addition, these types of pads tend to break up in use so that paper and the contents of the pad may adhere to the food and leakage may occur from the packages.
  • the food preservation composition should prevent or reduce the growth of microbial agents produced by food products. It would be desirable to prevent or reduce the growth of microbial agents not only in the exudate produced by the food product but also on the surface of the food product. This will ultimately prolong the shelf life of the food product and potentially inhibit the proliferation of foodbome pathogens.
  • the food preservation composition should be easy to handle so that it can be incorporated into a variety of food storage articles or package structures. The food preservation compositions described herein satisfy these needs.
  • compositions are composed of an absorbent material and an antimicrobial agent.
  • the antimicrobial agent can be a volatile, nonvolatile, or a combination thereof.
  • the compositions are effective in reducing or preventing microbial growth in food storage articles.
  • a food preservation composition includes an absorbent material and one or more antimicrobial agents.
  • the absorbent material includes at least one water absorbing, non-crosslinked polymer, at least one mineral composition and at least one water-soluble salt.
  • the one or more antimicrobial agents include one or more of the following: an alkylpyridinium salt; an acyl arginine alkyl ester or a salt thereof; and an a,co- alkylenediamine tetraacetic acid or a salt thereof.
  • the at least one water-absorbing, non-crosslinked polymer includes one or more gel-forming water soluble polymers chosen from carboxymcthylccllulosc or a salt thereof, hydroxyethylcellulose, methylcellulose, hydroxypropylmethylcellulose, gelatinized starches, gelatin, dextrose, and a gum.
  • the at least one water-absorbing, non-crosslinked polymer constitutes about 50 to 92% by weight of the food preservation composition.
  • the at least one mineral composition comprises a clay, optionally one or more clays chosen from attapulgite, montmorillonite, bentonite, hectorite, sericite, and kaolin.
  • the at least one mineral composition constitutes about 3 to 30% by weight of the food preservation composition.
  • the at least one water-soluble salt is chosen from aluminum sulfate, potassium aluminum sulfate, calcium sulfate, potassium chloride, and sodium chloride.
  • the at least one water-soluble salt constitutes 1% to 20% by weight of the food preservation composition.
  • the antimicrobial agent is chosen from an alkylpyridinium salt, optionally a cetylpyridinium salt, optionally cetylpyridinium chloride.
  • the antimicrobial agent is chosen from an acyl arginine alkyl ester or a salt thereof, optionally an acyl arginine ethyl ester or a salt thereof, optionally an acetyl arginine alkyl ester or a salt thereof, optionally an acetyl arginine ethyl ester or a salt thereof.
  • the antimicrobial agent is chosen from an a, coalkylenediamine tetraacetic acid or a salt thereof, optionally ethylenediamine tetraacetic acid or a salt thereof.
  • the disclosed concept is directed to a method of reducing microbial outgrowth in a foodstuff.
  • the method includes the step of storing the foodstuff in proximity to any food preservation composition disclosed herein.
  • the disclosed concept is directed to a package having an internal compartment into which the food preservation composition of any embodiment disclosed herein is disposed.
  • the food preservation composition is disposed in a reservoir located in a bottom portion of the internal compartment, the internal compartment further including a product containing space located above the reservoir and a platform or filter configured to physically separate the product from the food preservation composition and to suspend the product over the reservoir.
  • Such configurations may be provided in the form of or utilizing an absorbent article, a pad, a pouch, a stand-up pouch or a tray, as disclosed herein, for example.
  • FIG. 1A shows control of Salmonella in fresh diced tomato (matrix) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. IB shows control of Listeria in fresh diced tomato (matrix) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 1C shows control of E. coli in fresh diced tomato (matrix) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 2A shows control of Salmonella in fresh diced tomato (gel pad) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 2B shows control of Listeria in fresh diced tomato (gel pad) by (i) EDTA (ii) LAE
  • FIG. 2C shows control of E. coli in fresh diced tomato (gel pad) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 3A shows control of microbial load by (i) EDTA (ii) LAE (iii) CPC in a matrix of diced tomatoes.
  • FIG. 3B shows control of microbial load by (i) EDTA (ii) LAE (iii) CPC in a gel pad on which inoculated diced tomatoes rested.
  • FIG. 4A shows control of Salmonella in shrimp (matrix) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 4B shows control of Listeria in shrimp (matrix) by (i) EDTA (ii) LAE (iii) CPC and
  • FIG. 4C shows control of E. coli in shrimp (matrix) by (i) EDTA (ii) LAE (iii) CPC and (iv) control with no antimicrobial.
  • FIG. 5A shows control of Salmonella in a gel pad on which inoculated shrimp rests by (i) EDTA (ii) LAE (iii) CPC (iv) control with no antimicrobial.
  • FIG. 5B shows control of Listeria in a gel pad on which inoculated shrimp rests by (i) EDTA (ii) LAE (iii) CPC (iv) control with no antimicrobial.
  • FIG. 5C shows control of E. coli in a gel pad on which inoculated shrimp rests by (i) EDTA (ii) LAE (iii) CPC (iv) control with no antimicrobial.
  • FIG. 6A shows control of microbial load by (i) EDTA (ii) LAE (iii) CPC in a matrix of shrimp.
  • FIG. 6B shows control of microbial load by (i) EDTA (ii) LAE (iii) CPC in a gel pad on which inoculated shrimp rests.
  • FIG. 7 is a top plan view of an absorbent article that may incorporate aspects of the disclosed technology.
  • FIG. 8 is a side elevational view of the article of Fig. 7.
  • FIG. 9 is a bottom perspective view of a package in the form of a stand-up pouch.
  • FIG. 10 is a partially exploded isometric view of an optional embodiment of a container in the form of a tray.
  • FIG. 11 is a cross-sectional side elevation view of the container of FIG. 10.
  • CPC cetylpyridinium chloride
  • EDTA ethylenediamine tetraacetic acid
  • LAE ethyl lauroyl arginate
  • efu colony-forming unit
  • NoAM non-antimicrobial.
  • alkyl refers to a straight-chain or branched fully saturated or unsaturated hydrocarbon moiety. In some embodiments, the alkyl is fully saturated. In some embodiments, the alkyl contains 1, 2, or 3 alkene groups. In some embodiments, the alkyl has the formula CnH n+i, with n being a nonzero integer. In some embodiments, the alkyl has the chemical structure (CH2) n -iCH3. In some embodiments, the alkyl has the formula C n H2n-i, with n being an integer. In some embodiments, the alkyl has the formula C n H2 n -3, with n being an integer.
  • the integer n is between 1 and 20, inclusive. In some embodiments, the integer n is between 1 and 16, inclusive. In some embodiments, the integer n is between 1 and 12, inclusive. In some embodiments, the integer n is between 1 and 8, inclusive. In some embodiments, the integer n is between 1 and 6, inclusive. In some embodiments, n is 2 or greater. In some embodiments, n is 4 or greater.
  • Representative alkyl groups include hexyl, octyl, decyl, dodecyl, tetradecyl, hexadecyl (cetyl), octadecyl, and eicosanyl. Unless stated otherwise, the alkyl groups in a compound having two or more alkyl groups can be the same or different.
  • a,co-alkylenediamine refers to a compound having the chemical formula H 2 N-(CH 2 ) n -NH 2 , with n being an integer greater than or equal to 2. In some embodiments, n is 6 or less. In some embodiments, n is 4 or less. In some embodiments, n is 3 or less.
  • a,co-alkylenediamine tetraacetic acid refers to a compound having the chemical formula (HOOC-CH 2 ) 2 N-(CH 2 )n-N(CH 2 COOH) 2 , with n being an integer greater than or equal to 2. In some embodiments, n is 6 or less. In some embodiments, n is 4 or less. In some embodiments, n is 3 or less.
  • references in the specification and concluding claims to parts by weight, of a particular element or component in a composition or article denotes the weight relationship between the element or component and any other elements or components in the composition or article for which a part by weight is expressed.
  • X and Y are present at a weight ratio of 2:5 and are present in such ratio regardless of whether additional components are contained in the compound.
  • a weight percent of a component is based on the total weight of the formulation or composition in which the component is included.
  • compositions are composed of an absorbent composition and an antimicrobial agent.
  • the absorbent composition and antimicrobial agent are described in detail below. Due to the fact that the compositions are used in food preservation applications, all components used to produce the absorbent compositions as well as the antimicrobial agent are selected from materials that are approved by the FDA as food additives.
  • the food preservation compositions described herein provide the necessary gel strength and absorbency criteria for food packaging applications with the additional benefits of an antimicrobial agent incorporated therein.
  • the absorbent composition is composed of (i) at least one water-absorbing polymer; (ii) at least one mineral composition, and (iii) at least one water-soluble salt comprising at least one trivalent cation.
  • the water-absorbing polymer can be derived from natural sources or synthesized to meet specific requirements. In general, the water-absorbing polymer forms a gel upon contact with water.
  • the water-absorbing polymers are also referred to herein as hydrogels.
  • the polymer comprises a non-crosslinked gel-forming water-soluble polymer.
  • the amount of polymer present in the absorbent composition can be from 50% to 92%, 50% to 80%, 60% to 80%, or 70% to 80% by weight of the food preservation composition.
  • water-absorbing polymers include, but are not limited to, carboxymethylcellulose (CMC) and or a salt thereof, hydroxyethylcellulose, methylcellulose. hydroxypropylmethylcellulose, gelatinized starches, gelatin, dextrose, gums, or any combination thereof.
  • the water-absorbing polymer is the sodium salt of CMC having a degree of substitution of about 0.7 to 0.9, where the degree of substitution refers to the proportion of hydroxyl groups in the cellulose molecule that have their hydrogen substituted by a carboxymethyl group.
  • CMC supplied by Dow Wolff Cellulosics (Willowbrook, Ill.) sold under the tradename Walocel CRT 6000) can be used herein.
  • the water-absorbing polymer can be the polymerization product of a carboxyl-containing ethylenically unsaturated monomer alone or in combination with one or more other ethylenically unsaturated monomers.
  • carboxyl-containing ethylenically unsaturated monomers include, but are not limited to, acrylic acid, methacrylic acid, dimethacrylic acid, ethylacrylic acid, crotonic acid, isocrotonic acid, vinylacetic acid, allylacetic acid, maleic acid, fumaric acid, itaconic acid, methylenemalonic acid, maleic acid, maleic anhydride, itaconic acid, itaconic anhydride, or any combination thereof.
  • ethylenically unsaturated monomers that can be copolymerized with the carboxyl-containing ethylenically unsaturated monomers include, but are not limited to, (meth)acrylamide, (meth)acrylonitrile, vinylpyrrolidone, vinylacetamide, 2-acrylamido-2-methylpropanesulfonic acid, vinylsulfonic acid, (meth)allylsulfonic acid, hydroxyethyl acrylate, alkylaminoalkyl(meth)acrylates, alkylaminopropylacrylamides, acrylamidopropyltrimethylammonium chloride, or any combination thereof.
  • the polymers and techniques for making the same disclosed in U.S. Pat. Nos. 7,101,946 and 7,173,086 can be used herein.
  • the polymerization products described above can be crosslinked using techniques known in the art.
  • the polymerization product can be partially neutralized or completely neutralized with an alkali metal base or alkaline earth metal base.
  • the polymerization product can be polyacrylic acid partially neutralized with a sodium or potassium base (e.g., hydroxide).
  • the mineral composition is generally any material that is porous and traps water but does not swell such as the water-absorbing polymer.
  • the mineral composition is from 3 to 30%. 10 to 30%, or 20 to 30% by weight of the food preservation composition.
  • the mineral composition includes one or more clays.
  • clays useful herein include, but are not limited to, attapulgite, montmorillonite, bentonite, hectorite, sericite, kaolin, diatomaceous earth, silica, and mixtures thereof.
  • bentonite is used. Bentonite is a type of montmorillonite and is principally a colloidal hydrated aluminum silicate that contains varying quantities of iron, alkali, and alkaline earths.
  • bentonite A type of bentonite useful herein is hectorite, which is mined from specific areas, principally in Nevada.
  • bentonite manufactured by American Colloid Company of Arlington Heights, Ill. under the tradename Bentonite AE-H can be used herein.
  • the water-soluble salt used in the absorbent composition comprises at least one trivalent cation, which provides a cross linking effect on the water-absorbing polymer once the solution is added.
  • the soluble salt is aluminum sulfate, potassium aluminum sulfate, and other soluble salts of metal ions such as aluminum, chromium, and the like. Additional salts that can be used in combination with the trivalent cation include calcium sulfate, potassium chloride, and sodium chloride.
  • the soluble salt is from 1 to 20%, 1 to 15%, or from 1 to 8% by weight of the food preservation composition.
  • the absorbent composition can include additional components.
  • the composition can include one or more inorganic buffers such as sodium carbonate (soda ash), sodium hexametaphosphate, sodium tripolyphosphate, and other similar materials.
  • inorganic buffers such as sodium carbonate (soda ash), sodium hexametaphosphate, sodium tripolyphosphate, and other similar materials.
  • natural gums such as xanthan, guars, and alginates can be used as inorganic buffers.
  • One or more antimicrobial agents are admixed with the absorbent composition to produce the food preservation composition.
  • the term “antimicrobial agent” is defined herein as any compound that inhibits or prevents the growth of microbes on or near a food article as well as kill microbes on and/or near the food article.
  • the term “microbe” is defined herein as a bacterium, fungus, or virus.
  • the selection of the antimicrobial agent can vary depending upon the end-use of the food preservation composition (e.g., the type of food, storage device, etc.).
  • the antimicrobial agents useful herein include volatile antimicrobial agents and non-volatile antimicrobial agents. Combinations of volatile and non-volatile antimicrobial agents are also contemplated and will be discussed below.
  • volatile antimicrobial agent includes any compound that when it comes into contact with a fluid (e.g., water or the juice from a food product), produces a vapor of antimicrobial agent.
  • a fluid e.g., water or the juice from a food product
  • the volatile antimicrobial agent is generally used in a closed system so that the antimicrobial vapor does not escape.
  • the volatile antimicrobial agent is from 0.25 to 20%, 0.25 to 10%, or 0.25 to 5% by weight of the food preservation composition.
  • volatile antimicrobial agents include, but are not limited to, origanum, basil, cinnamaldehyde, chlorine dioxide, vanillin, cilantro oil, clove oil, horseradish oil, mint oil, rosemary, sage, thyme, wasabi or an extract thereof, a bamboo extract, an extract from grapefruit seed, an extract of Rheum palmatum, an extract of coptis chinesis, lavender oil, lemon oil, eucalyptus oil, peppermint oil, cananga odorata, cupressus sempervirens, curcuma longa, cymbopogon citratus, eucalyptus globulus, pinus radiate, piper crassinervium, psidium guayava, rosmarinus officinalis, zingiber officinale, thyme, thymol, allyl isothiocyanate (AIT), hinokitiol, carvacrol, eugenol,
  • the volatile antimicrobial agent can be used alone or in combination with other solvents or components.
  • the release of the volatile antimicrobial agent can be varied by the presence of these solvents or components.
  • one or more food safe solvents such as ethanol or sulfur dioxide can be mixed with the volatile antimicrobial agent prior to admixing with the absorbent composition.
  • the volatile antimicrobial agent can be coated with one or more water-soluble materials. Examples of such water-soluble material include cyclodextrin, maltodextrin, corn syrup solid, gum arabic, starch, or any combination thereof.
  • the materials and techniques disclosed in U.S. Published Application No. 2006/0188464 can be used herein to produce the coated volatile antimicrobial agents.
  • non-volatile antimicrobial agent includes any compound that when it comes into contact with a fluid (e.g., water or the juice from a food product), produces minimal to no vapor of antimicrobial agent.
  • a fluid e.g., water or the juice from a food product
  • the non-volatile antimicrobial agent is from 0.5 to 15%, 0.5 to 8%, or 0.5 to 5% by weight of the food preservation composition.
  • nonvolatile antimicrobial agents include, but are not limited to, ascorbic acid, a sorbate salt, sorbic acid, citric acid, a citrate salt, lactic acid, a lactate salt, benzoic acid, a benzoate salt, a bicarbonate salt, a chelating compound, an alum salt, nisin, or any combination thereof.
  • the salts include the sodium, potassium, calcium, or magnesium salts of any of the compounds listed above. Specific examples include calcium sorbate, calcium ascorbate, potassium bisulfite, potassium metabisulfite, potassium sorbate, or sodium sorbate.
  • the food preservation composition comprises an antimicrobial agent chosen from an alkylpyridinium salt.
  • an antimicrobial agent chosen from an alkylpyridinium salt.
  • alkylpyridinium salts may consist of 1: 1 mixtures of the positively charged alkylpyridinium and a monoanion.
  • Exemplary monoanions can include chloride, bromide, acetate, nitrate, hydrogen sulfate (also known as bisulfatc), and dihydrogcn phosphate.
  • Alkylpyridinium salts may consist of 2: 1 mixtures of the positively charged alkylpyridinium and a dianion.
  • Exemplary dianions include sulfate, monohydrogen phosphate, maleate, fumarate, tartrate, and succinate.
  • Alkylpyridinium salts may consist of 3: 1 mixtures of the positively charged alkylpyridinium and a trianion.
  • Exemplary trianions not intended to be limiting, include phosphate and citrate.
  • the alkylpyridinium is hexadecylpyridinium (also known as cetylpyridinium).
  • the alkylpyridinium salt is alkylpyridinium halide. In certain embodiments, the alkylpyridinium salt is alkylpyridinium chloride. In certain embodiments, the alkylpyridinium salt is cetylpyridinium halide. In certain embodiments, the alkylpyridinium salt is cetylpyridinium chloride.
  • the food preservation composition comprises an antimicrobial agent chosen from acylarginine alkyl ester, or a salt thereof.
  • the antimicrobial agent is chosen from acetylarginine alkyl ester, or a salt thereof.
  • the antimicrobial agent is chosen from acylarginine methyl ester, or a salt thereof.
  • the antimicrobial agent is chosen from acylarginine ethyl ester, or a salt thereof.
  • the antimicrobial agent is acetylarginine methyl ester, or a salt thereof.
  • the antimicrobial agent is acetylarginine ethyl ester, or a salt thereof.
  • the food preservation composition comprises an antimicrobial agent chosen from an a,co-alkylenediamine tetraacetic acid or a salt thereof.
  • the antimicrobial agent is ethylenediamine tetraacetic acid (“EDTA”).
  • the selected antimicrobial agent(s) and absorbent may be combined in an admixture, which includes a mixture of the components or agglomerated particles of the components.
  • Sealing equipment, product trays (ki Steam Trays; shallow), sealing film, and antimicrobial gel pads were provided by Aptar CSP Technologies.
  • Each culture was prepared from a lyophilized preparation according to manufacturer’s instructions or from stock plates. Cultures were transferred into Tryptic Soy Broth (TSB, Hardy Diagnostics, Santa Maria, CA) and incubated at 35 ⁇ 2°C. After incubation, the cultures were verified by streaking onto the agars disclosed in Table 4.
  • TLB Tryptic Soy Broth
  • Tests were run concurrently for evaluation of the efficacy of antimicrobial-treated gel pads towards reducing colony count of microbes.
  • Samples of each foodstuff matrix were inoculated by adding a volume of each challenge organism/cell suspension to the sample surface.
  • the target concentration was approximately 10 5 efu / sample.
  • Control trays contained a non-antimicrobial gel pad (designated NoAM).
  • gel pads containing one of three different antimicrobial treatments designated EDTA, LAE, and CPC
  • EDTA, LAE, and CPC gel pads containing one of three different antimicrobial treatments
  • EDTA, LAE, and CPC were placed in *4 of the tray area (non-woven side up).
  • approximately 1 lb. of foodstuff matrix was placed in the tray, in contact with the pad.
  • a single uninoculated tray without a gel pad was also prepared (“Uninoculated control”). All trays were then sealed and placed in refrigerated storage. A total of 47 trays of samples were prepared as set forth in Table 5, table below.
  • Samples (25g each, 3 per tray, taken from the top, middle, and bottom portion of the foodstuff matrix where possible) were combined with a volume of sterile diluent (Butterfield’s Phosphate Buffer) to create a 1:10 dilution.
  • the sample was stomached for up to 1 minute at high speed.
  • the gel pad was also sampled, as with the foodstuff matrices above, and enumerated as per the type of tray from which it was recovered.
  • Raw counts were averaged across trays and, for foodstuff matrix examination, sample origin (top I middle I bottom of tray) for each gel type, microbial target, and sample source (foodstuff matrix / gel pad), to provide a single mean count for each testing interval.
  • the mean count observed for each sample was converted to logio cfu / sample.
  • each challenge organism/cell suspension or the amount of aerobic organisms present at each testing interval was compared to the amount present in the initial samples to determine the ability of each antimicrobial to control the outgrowth of each pathogen (or general microbial load in the case of uninoculated samples) for each matrix.
  • Example 5 Control of microbes in diced tomato samples.
  • Control of microbes by the treated pads was evaluated using the procedure set forth above. Samples of diced tomato were purchased commercially from Analytical Food Laboratories (AFL).
  • Pathogen reduction was typically similar in both diced tomato and shrimp matrix samples, with reductions in the 0.5 to 1.0 log range as compared to the respective NoAM control samples.
  • One exception was the reaction of the LAE pad against Listeria in shrimp, which remained at a reduced level by Day 7, while the other two antimicrobial pads saw a sharp rise in Listeria levels.
  • pathogen counts were typically level or showed a reduction by Day 7 for the tomato samples, while pathogen counts were level or showed a slight increase in shrimp samples.
  • Background counts for tomato and shrimp matrices were similar for all pad types. Background counts in gel samples for tomato and shrimp trays showed some different responses, with numbers typically higher for the EDTA gel. The lowest recovery for background aerobic counts was seen in the CPC gel in the shrimp trays.
  • Samples were evaluated for aerobic plate count (“APC”), coliform, including E. coli (“EB”), lactic acid bacteria (“LAB”), and yeast and mold (“YM”).
  • APC aerobic plate count
  • coliform including E. coli (“EB”), lactic acid bacteria (“LAB”), and yeast and mold (“YM”).
  • EB E. coli
  • LAB lactic acid bacteria
  • yeast and mold yeast and mold
  • Results for the CPC-treated pad in the matrix and pad are reported in Tables 17 and 18, respectively.
  • Results for the EDTA-treated pad in the matrix and pad are reported in Tables 19 and 20, respectively.
  • Results for the LAE-treated pad in the matrix and pad are reported in Tables 21 and 22, respectively.
  • antimicrobial compositions disclosed herein may be incorporated into various packaging structures.
  • the packaging structure may be an article that optionally incorporates an absorbent material and any of the antimicrobial compositions described herein.
  • the antimicrobial composition and optionally also absorbent material can be placed between laminations or layers of liquid permeable materials such as non-woven fabric, cellulose fiber webs, etc. or between liquid impermeable fibers of melt-blown sheeting, etc. Liquid permeable layers can also be laminated to a layer of impermeable material such as a polymeric film.
  • the absorbent held between the layers, laminates or fibers will optionally swell on contact with fluids permeating through to the absorbent material.
  • the gel which forms retains the moisture within the structure of the absorbent article and is not released.
  • the antimicrobial composition that is mixed with or agglomerated to the absorbent material inhibits microbes in the vicinity of the article.
  • the lamination may be constructed in such a way that the components of the lamination are sealed to each other in continuous fashion around the periphery of the absorbent article, or in cross hatch or quilted pattern to allow small amounts of the absorbent to be held in pockets within the absorbent structure.
  • the cross hatch seals can be designed to create a cellular pattern of varying sizes and shapes dependent upon the level and uniformity of absorption needed for the particular application.
  • FIGS. 7 and 8 A specific embodiment of a laminated structure is illustrated in FIGS. 7 and 8.
  • the structure is especially useful for storage of food products which exude liquids but may have other applications.
  • the structure may provide the advantage of prolonging the preservation or shelf life of food products, such as produce or seafood.
  • an absorbent package 10 comprises a two walled bag having a first wall 12 of a liquid impervious and preferably transparent thermoplastic such as polyethylene.
  • This layer preferably has a low gas permeability for meat and poultry products but a higher gas permeability for fruit and vegetable products to allow ethylene to escape from inside the package and oxygen to move inside the package.
  • the desired specific OTR (oxygen transport rate) of the layer will depend upon the foods to be packaged.
  • the second wall 14 of the bag is a laminated structure having at least two plies, a first ply 16 which is on the outside of the bag and comprises a liquid impervious thermoplastic such as polyester/polyethylene laminate and a second ply 18, which faces the food product, and comprises a liquid and gas permeable material.
  • This material should be compatible with food items and can be a bi-component non-woven fabric comprised of fibers having a polyester core with a polyethylene sheath.
  • the fabric is made through standard techniques such as by carding the fibers, passing the carded fibers through an oven, and then through nip rolls to “iron” the fabric into a more compact non-woven fabric. In addition, the heat and ironing cause fusion between the fibers.
  • the non-woven permeable inner ply 18 is heat sealed to the polyester/polyethylene outer ply 16 in a pattern so as to form an array of cells 20.
  • an absorbent such as the one disclosed herein is placed between the two plies, so that a certain amount of absorbent 22 is trapped within each cell.
  • the resulting absorbent material can be fashioned into a number of different structure or flexible packages, such as pouches, thermoformed packs, lidding materials, or other packages.
  • a large double walled sheath of material can be prepared and then cut to the desired size and heat sealed around three sides 24, 26, 28 to form a bag having an open side 30 with flap 32.
  • the flap 32 can be an overlapping piece of either the polyethylene first wall or the polyester/ polyethylene ply. After filling the absorbent package 10 with the product (such as diced fruit or tomatoes, seafood, poultry parts or meats) the flap 32 can be folded over and heat sealed to the bag.
  • the presence of the array of cells makes possible the formation of various size bags from the double walled sheet having discrete absorbent areas and prevents spillage of absorbent from between the two plies.
  • the two ply second wall can be made by standard techniques as can the two-wall sheath of material and the two wall bags.
  • the permeable or inner ply of the absorbent wall can have a dual layer structure with two layers of the same fibers.
  • the fibers are packed more closely together on the side which is closer to the absorbent and are packed into a more open network on the side closer to the packaged products.
  • the absorbent ply has smaller pores on the side closer to the absorbent and the absorbent is thus unlikely to migrate through the fabric.
  • the ply next to the liquid has larger pores to encourage migration of the liquid therethrough.
  • a flexible package e.g., in the form of a pouch
  • the invention is not intended to be limited to the embodiment described.
  • Other embodiments of flexible packages are envisioned utilizing the two-ply absorbent fabric described above.
  • the packaging structure into which any of the disclosed antimicrobial compositions and optionally an absorbent material may be incorporated is in the form of a standup pouch.
  • a package 110 in the form of a pouch can be formed by, on, in, or with a gusseted bottom pouch-making machine, such as that disclosed in U.S. Publication No. 2022/0402679 Al , which is hereby incorporated by reference in its entirety.
  • the package 110 can be formed by, on, or with a flat bottom pouch-making machine.
  • the package 110 is optionally formed of a single sheet of film that is folded at certain locations to form a stand-up pouch. Alternatively, the package 110 is formed of two or more sheets of film that are attached at certain locations.
  • the package 110 may include a means for containing absorbent located at or proximate to an interior surface of a bottom thereof.
  • the package 110 comprises an upper compartment 130 configured to hold a product, a lower compartment 132 configured to hold the absorbent material 116 and a liquid-permeable filter 134 separating the upper compartment 130 from the lower compartment 132.
  • An entire outer periphery of the filter 134 is preferably attached to an interior surface of the single sheet or the two or more sheets and a remaining portion of the filter being flexible or movable with respect to the package 110.
  • the top 124 of the package 110 can be sealed shut or otherwise closed.
  • the filter 134 can form a pocket (e.g., the second compartment 132) that contains the absorbent material 116 in the package 110.
  • the amount of the absorbent material can be modified depending upon the particular application and customer needs.
  • the pocket would have substantial additional space not taken up by the absorbent material to give the absorbent material room to swell when it absorbs liquid.
  • the package 110 can be a mono-material pouch to allow the package 110 to be easily recyclable and/or compostable.
  • the film (making up the walls of the pouch) and the filter 134 can be formed of the same or similar material, such as polypropylene.
  • the filter 134 can be made from polylactic acid (PLA) and the film can be formed from parchment paper.
  • the absorbent material 116 may further include any of the antimicrobial agents disclosed herein.
  • any of the antimicrobial agents disclosed herein may be provided in the lower compartment 132 without absorbent, to provide an antimicrobial effect in the package 110.
  • the packaging structure into which any of the disclosed antimicrobial agents and optionally an absorbent material may be incorporated is in the form of a tray.
  • FIG. 10 and 11 views of an optional embodiment of a container 210 in the form of a tray, which may be used according to optional aspects of the disclosed concept.
  • the container 210 i.e., tray
  • the container 210 can comprise an internal compartment 212 having a product containing space 214 for holding product 216 and a reservoir 218 below the product containing space 214.
  • the reservoir 218 is configured to retain liquid exudate from the product 216.
  • an absorbent material 220 is provided within the reservoir 218.
  • the absorbent material may be in the form of one or more of: absorbent powders, granules, fibers, a sponge, a gel and a coating on a surface within the reservoir, for example.
  • a preferred absorbent material includes solid powder or granules that form a gel upon absorbing liquid. Such absorbent materials are described above.
  • one or more of the disclosed antimicrobial agents may be provided within the reservoir 218.
  • the optional absorbent material 220 absorbs the liquid (e.g., by becoming gelatinous) so as to prevent the liquid from splashing, flowing or leaking from the reservoir 218 back into the product containing space 214. Further, the one or more antimicrobial agents in the reservoir 218 helps reduce the presence of problematic microbes in the container 210.
  • the container 210 optionally comprises a base 222 and a sidewall 224 extending upwardly (e.g., generally or substantially perpendicularly) from the base 222.
  • the base 222 and at least a portion of the sidewall 224 (e.g., a portion directly and continuously extending from the base 222) define the reservoir 218.
  • the reservoir 218 can be fully enclosed along and/or surrounded by the base 222 and along at least a portion of the sidewall 224 extending directly and continuously from the base 222.
  • the reservoir 218 is configured to retain liquid, such as liquid exudate from product packaged in the container 210.
  • the reservoir 218 is configured to prevent liquid received therein from leaking outside of the container 210.
  • the sidewall 224 terminates at a peripheral edge 226 surrounding a container opening 228 through which product may be deposited into the container 210 or removed therefrom.
  • the container 210 can further include a support structure 230 disposed in the internal compartment 212. At least a portion of the support structure 230 is rigid or semi rigid, so as to retain its shape under gravity and to support a predetermined amount of product without collapsing under the weight of the same.
  • the support structure 230 can define at least a portion of a platform 232 at an upper end 234 thereof.
  • the platform 232 can be located above the reservoir 218 (e.g., at a height above the height of the reservoir, whether or not the product is at a location axially aligned with the reservoir directly below).
  • the platform is itself a surface at the upper end of the support structure.
  • the platform includes the aforementioned surface as well as a cover, layer or membrane placed thereon. The optional cover, as a component of a platform according to some embodiments, is further discussed below.
  • the support structure 230 and platform 232 are configured to support the product 216 placed thereon.
  • the support structure 230 may be configured to hold up to 5 pounds (2.27 kg), optionally up to 10 pounds (4.54 kg), optionally up to 15 pounds (6.80 kg), optionally up to 20 pounds (9.07 kg) of product over a period of at least two weeks, without collapsing under the weight of the same.
  • the support structure 230 and the platform 232 are configured to suspend the product 216 above the reservoir 218 so as to separate the product 216 from its exuded juices, which may, via gravity, be directed into the reservoir 218.
  • the platform 232 and/or the support structure 230 are configured to direct liquid exuded from the product 216 to the reservoir 218. This may be achieved in a variety of ways, exemplary implementations of which are elaborated upon below.
  • the container 210 includes a lid 236 to enclose the product 216 within the container 210.
  • the lid may include a rigid or semirigid removable and replaceable closure means, e.g., a snap on lid.
  • the lid 236 can include a flexible lidding film 238. Examples of a lid 236 including a flexible lidding film 238 are shown covering and enclosing internal compartments 212 of exemplary embodiments of containers 210.
  • the lidding film 238 is depicted as having an exaggerated thickness, just so that it is more clearly visible in the figures. In reality, the film’s thickness would preferably be less than depicted. For example, the film may be from 0.001 inches to 0.003 inches thick.
  • the lidding film 238 is secured to the peripheral edge 226 of the side wall 224, of the container 210. e.g., by a tie layer.
  • the tie layer is a polyethylene tie layer that is optionally co-extruded onto the peripheral edge 226 to bond the lidding film 238 thereto by a heat seal 240.
  • the lid 236 and/or the lidding film 238 can be transparent, translucent or opaque.
  • the lid Regardless of the form of the lid, it can be important that the lid provide a desirable oxygen transmission rate for product.
  • Packaging that provides an oxygen transmission rate of 10,000 cc/m2/24hrs at 24°C, or higher, is regarded as an oxygen-permeable packaging material for product.
  • An oxygen permeable package should provide sufficient exchange of oxygen to allow naturally occuning, aerobic spoilage organisms on the product to grow and spoil the product before toxin is produced under moderate abuse temperatures.
  • a lidding film 238 is disposed over the product containing space 214 to enclose the product 216 stored therein so as to provide an oxygen permeable package.
  • the container is enclosed with a lidding film that provides an oxygen transmission rate of at least 10,000 cc/m2/24hrs at standard temperature and pressure (ASTM D3985).
  • a lidding film that provides an oxygen transmission rate of at least 10,000 cc/m2/24hrs at standard temperature and pressure (ASTM D3985).
  • Such film is known in the field as a 10K OTR lidding film.
  • a lidding film providing less than 100 cc/m2/24hrs may be used.
  • the lidding film is transparent, which allows a user to view the quality of the product, such as produce, meat, poultry or seafood stored in the container.
  • the lidding film is a polyethylene composition, optionally a biaxially stretched polyethylene composition.
  • the lidding film may be the PLASTOFRESH 10K by PLASTOPIL or the 10K OTR Vacuum Skin Package film by CRYOVAC®.
  • the container 210 is optionally a thermoformed polymer tray (although other materials may be used).
  • the container 210 includes a support structure 230 in the internal compartment 212.
  • the support structure 230 includes a perimeter rib 246 running along an entire perimeter of the sidewall 224 and a plurality of intersecting ribs 248, each of which extends from the perimeter rib 246, across the base 222 and to an opposite end of the perimeter rib 246.
  • the upper end 234 of the support structure 230 forms a portion of the platform 232.
  • the platform 232 also includes a cover 250, optionally made from a filter or membrane, e.g., comprising a non-woven material.
  • the cover 250 in this embodiment thus provides a liquid permeable surface, which is configured to direct liquid exuded from the product 216 into the reservoir 218.
  • an absorbent material 220 with an antimicrobial agent disclosed herein is provided in the wells 244 of the reservoir 218.
  • the cover 250 comprises a spunbond synthetic nonwoven material. If a spunbond synthetic nonwoven material is used for the cover, a preferred brand is the AHLSTROM WL257680. Preferably, the material is food contact safe and is compliant with U.S. Federal Food and Drug Administration regulations 21 C.F.R. ⁇ 177.1630 and 177.1520.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

L'invention divulgue des compositions de conservation d'aliments et leur utilisation. L'invention divulgue également des configurations d'emballage utilisant de telles compositions. Les compositions comprennent un matériau absorbant et un ou plusieurs agents antimicrobiens. Le matériau absorbant comprend au moins un polymère non réticulé absorbant l'eau, au moins une composition minérale et au moins un sel soluble dans l'eau. Le ou les agents antimicrobiens comprennent un ou plusieurs éléments parmi un sel d'alkylpyridinium, un ester alkylique d'acyle arginine ou un sel de celui-ci, et un acide tétraacétique α,ω-alkylènediamine ou un sel de celui-ci.
PCT/US2023/075093 2022-09-26 2023-09-26 Utilisation d'antimicrobiens non volatils dans un emballage alimentaire WO2024073392A1 (fr)

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US63/377,082 2022-09-26

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US20060188464A1 (en) 2003-01-20 2006-08-24 Amelie Bochot Microencapsulation systems and applications of same
US7101946B2 (en) 2002-02-14 2006-09-05 Stockhausen Gmbh Water-absorbing polymers having interstitial compounds, a process for their production, and their use
US7173086B2 (en) 2003-10-31 2007-02-06 Stockhausen, Inc. Superabsorbent polymer with high permeability
WO2008091466A1 (fr) * 2007-01-22 2008-07-31 Maxwell Chase Technologies, Llc Compositions de conservation d'aliments et procédés de leur utilisation
US20180007909A1 (en) * 2015-02-06 2018-01-11 Microbio Solutions Inc. Antimicrobial composition
WO2018044840A1 (fr) * 2016-08-31 2018-03-08 Cryovac, Inc. Agents synergiques cationiques conduisant à une inhibition microbienne sur des surfaces d'aliments et sur des surfaces dures
WO2020132374A1 (fr) * 2018-12-19 2020-06-25 Maxwell Chase Technologies, Llc Procédés d'emballage et de conservation de petits fruits
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US20060188464A1 (en) 2003-01-20 2006-08-24 Amelie Bochot Microencapsulation systems and applications of same
US7173086B2 (en) 2003-10-31 2007-02-06 Stockhausen, Inc. Superabsorbent polymer with high permeability
WO2008091466A1 (fr) * 2007-01-22 2008-07-31 Maxwell Chase Technologies, Llc Compositions de conservation d'aliments et procédés de leur utilisation
US20180007909A1 (en) * 2015-02-06 2018-01-11 Microbio Solutions Inc. Antimicrobial composition
WO2018044840A1 (fr) * 2016-08-31 2018-03-08 Cryovac, Inc. Agents synergiques cationiques conduisant à une inhibition microbienne sur des surfaces d'aliments et sur des surfaces dures
WO2020132374A1 (fr) * 2018-12-19 2020-06-25 Maxwell Chase Technologies, Llc Procédés d'emballage et de conservation de petits fruits
US20220402679A1 (en) 2020-04-02 2022-12-22 Csp Technologies, Inc. Package configured to hold products and having active member attached to an interior surface thereof, and method of making same

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