WO2024067449A1

WO2024067449A1 - Parameter adjusting apparatus and method therefor, program-controlled device, medical system, and storage medium

Info

Publication number: WO2024067449A1
Application number: PCT/CN2023/120956
Authority: WO
Inventors: 周国新
Original assignee: 景昱医疗科技（苏州）股份有限公司
Priority date: 2022-09-29
Filing date: 2023-09-25
Publication date: 2024-04-04
Also published as: CN115463347A

Abstract

The present application provides a parameter adjusting apparatus, a parameter adjusting method, a program-controlled device, a medical system, and a readable storage medium. The parameter adjusting apparatus comprises a processor, and the processor is configured to achieve the following steps: displaying, by using a display apparatus, an output pattern of electrical stimulation signals delivered to in vivo tissues of a patient by a stimulator; determining an adjusted stimulation parameter and an adjusted parameter value thereof when an adjustment operation of a target person for the output pattern is received by using an interaction apparatus; displaying the output pattern that has been adjusted by using the display apparatus; and using the stimulator to deliver electrical stimulation corresponding to the output pattern that has been adjusted to the patient when a confirmation operation for the output pattern is received by using the interaction apparatus. The current output pattern and the adjusted output pattern are displayed by means of the display apparatus, and stimulation parameters are adjusted by adjusting the output pattern.

Description

Parameter adjustment device and method thereof, program-controlled equipment, medical system, and storage medium

This application claims priority to Chinese Patent Application No. 202211203039.4 filed on September 29, 2022, which is incorporated by reference in its entirety.

Technical Field

The present application relates to the technical field of implantable medical devices, for example, to parameter adjustment devices, parameter adjustment methods, program-controlled devices, medical systems and computer storage media.

Background technique

In the technical field of implantable medical devices, a programmable connection is established between the stimulator and the patient through a programmer. The doctor adjusts the configuration information of the stimulator through the doctor programmer to adjust the stimulation parameters of the stimulator. The patient can also adjust the configuration information of the stimulator through the patient programmer to adjust the stimulation parameters of the stimulator.

The user adjusts any stimulation parameter (such as amplitude) of the stimulator by selecting the stimulation parameter and re-entering it on the keyboard. When the user directly enters the parameter value in this way, he cannot intuitively recognize and judge the electrical stimulation signal corresponding to the parameter value, which means that the parameter adjustment device in the related art is easy to cause harm to the patient or make the patient feel uncomfortable.

Based on this, the present application provides a parameter adjustment device, a parameter adjustment method, a program-controlled device, a medical system and a computer-readable storage medium to solve the problems existing in the above-mentioned related technologies.

Summary of the invention

The purpose of the present application is to provide a parameter adjustment device, a parameter adjustment method, a programmable device, a medical system and a computer-readable storage medium, which display the current and adjusted output graphics through a display device, and adjust the stimulation parameters by adjusting the output graphics.

The purpose of this application is achieved by the following technical solutions:

In a first aspect, the present application provides a parameter adjustment device, the parameter adjustment device is used to visually adjust stimulation parameters of a stimulator implanted in a patient, the parameter adjustment device includes a processor, and the processor is configured to implement the following steps:

Displaying, by means of a display device, an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue, wherein the output graph is used to indicate stimulation parameters and parameter values of the electrical stimulation signal;

When an adjustment operation of the target person on the output graphic is received by the interactive device, determining the adjusted stimulation parameter and the adjusted parameter value;

Displaying the adjusted output graph using the display device;

When a confirmation operation for the output pattern is received by the interaction device, the stimulator is used to deliver electrical stimulation corresponding to the adjusted output pattern to the patient.

The beneficial effects of the technical solution are: using a display device to display the output graph of the electrical stimulation signal, which is different from the related display device that only displays the output value, can facilitate medical staff and non-medical patients to intuitively understand the relationship between the stimulation parameters and the electrical stimulation signal; directly adjust the output graph, and visualize (graphicalize) the adjusted stimulation parameters and parameter values, which is different from the related parameter values of the stimulation parameters. Adjustments are made so that the target person can adjust the stimulation parameters of the stimulator visually, so that the target person can have a more intuitive understanding of the effect of the stimulation parameter adjustment on the electrical stimulation of the patient's body tissue. It can be understood that the stimulation parameters and their parameter values are displayed in the output graph, and the electrical stimulation signal corresponding to the displayed output graph is delivered to the patient at the same time; the target person can use the interactive device to directly adjust the stimulation parameters and parameter values of the electrical stimulation signal indicated by the output graph, and use the display device to display the output graph after adjusting the parameter value in real time, and at the same time deliver the electrical stimulation corresponding to the adjusted stimulation parameters and parameter values to the patient in real time. On the one hand, before the target person adjusts the stimulation parameters and parameter values, the stimulator performs electrical stimulation treatment on the patient according to the original stimulation parameters and parameter values, so that the target person can compare the effect after adjustment with the effect before adjustment, shorten the time length for the target person to find the electrical stimulation suitable for the current stage, and enable the target person to master how to adjust the stimulation parameters of the stimulator more quickly and accurately; on the other hand, when the target person is the patient himself, when the stimulator delivers the electrical stimulation corresponding to the adjusted output graph to the patient, the display device displays the adjusted output graph in real time (which can be understood as an update of the output graph). When the patient feels that the adjusted electrical stimulation causes physical discomfort, the patient can further adjust the updated output graph in real time. Since the output graph is updated in real time, the patient has a more intuitive understanding of his adjustment of the output graph (stimulation parameters) at the first time, thereby improving the efficiency of the patient's parameter adjustment of the stimulator; on the other hand, the output graph can be used to indicate the stimulation parameters and parameter values of the electrical stimulation signal, which can more intuitively reflect the characteristics of the output waveform of the electrical stimulation, so that the target person can adjust the parameter values of the stimulation parameters more intuitively.

In summary, this embodiment provides a graphical parameter adjustment device, which displays the current and adjusted output graphics through a display device, and adjusts the stimulation parameters by adjusting the output graphics, so that the target person can make an intuitive understanding and judgment of the electrical stimulation signal corresponding to the parameter value, thereby avoiding the stimulation parameter adjustment from causing harm to the patient or causing discomfort to the patient.

In one embodiment, the parameter adjustment device is configured to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue using a display device in the following manner:

Using the display device to display a plurality of pre-set output graphics in the same display interface;

When a selection operation of the target person on one of the output graphics is received, the selected output graphic is displayed using the display device.

The beneficial effects of this technical solution are: multiple pre-set output graphics are displayed in the same display interface, and the target person can obtain information about the multiple output graphics without changing pages, which is convenient for the target person to compare and select the preset output graphics; when the target person is the patient himself, the display device displays the output graphics selected by the patient, which can reflect the patient's own reception degree of different electrical stimulation signals of the stimulator. Because the target person who adjusts the displayed output graphics is the patient himself, the patient's participation in the parameter adjustment process is improved.

In summary, selecting any pre-set output graphic as the output graphic for display in the same display interface reduces the difficulty for the target person to select the output graphic corresponding to the stimulation parameters and the degree of patient participation in the parameter adjustment process.

When a selection operation of the target person on one of the output graphics is received, the selected output graphic and its corresponding reference graphic are displayed simultaneously by the display device.

The beneficial effects of this technical solution are: multiple pre-set output graphics are displayed in the same display interface, and the target person can obtain the information of multiple output graphics without changing pages, which is convenient for the target person to compare and select the preset output graphics; any pre-set output graphic is selected as the output graphic for display in the same display interface, which reduces the difficulty of the target person selecting the output graphic corresponding to the stimulation parameters and the patient's participation in the parameter adjustment process; when the target person selects any output graphic, the display device simultaneously displays the reference graphic corresponding to the selected output graphic, which is convenient for medical staff and others to adjust the currently selected output graphic with reference to the reference graphic, thereby improving the accuracy of adjusting the patient's stimulator parameters.

In one embodiment, the target person is the patient himself, and the parameter adjustment device is configured to determine the adjusted parameter value of the adjusted stimulation parameter in the following manner:

An interactive device is used to receive a sliding operation of the target person on the output graphic, and a parameter value of one of the stimulation parameters of the output graphic is adjusted along a trajectory of the sliding operation to determine a parameter value of the adjusted stimulation parameter after adjustment.

The beneficial effect of the technical solution is that the parameter value of a stimulation parameter in the output graph can be adjusted by the trajectory of the patient's sliding operation, so as to reduce the difficulty of the patient adjusting the parameter value of the stimulation parameter using the interactive device. Because the patient's ability to operate the output graph cannot be compared with that of a normal person, the above setting is considered from the perspective of the patient's actual operation. Not only will the patient not feel irritated because the sliding operation can only adjust the parameter value of one stimulation parameter, but the patient will feel the humanized setting in the process of adjusting the stimulation parameter, so as to encourage the patient to cooperate with the stimulation treatment of the stimulator.

In one embodiment, the parameter adjustment device is configured to determine the adjusted stimulation parameters in the following manner:

Obtaining the corresponding relationship between the sliding operation and the stimulation parameters;

Based on the sliding operation and the corresponding relationship, determining the adjusted stimulation parameter;

Among them, the sliding direction of the up and down direction corresponds to the amplitude, and the sliding direction of the left and right direction corresponds to the pulse width.

The beneficial effect of this technical solution is that the patient does not need to memorize complicated operating instructions, nor does he need to enter data through the keyboard. The patient only needs to perform a simple sliding operation (up and down or left and right). Through the simple correspondence between the sliding operation and the stimulation parameters, the amplitude and pulse width parameters can be adjusted. This allows more patients with physical disabilities to use the above-mentioned parameter adjustment device to achieve visual stimulation parameter adjustment of the stimulator in the body.

In one embodiment, the parameter adjustment device is configured to determine the adjusted parameter value of the adjusted stimulation parameter in the following manner:

While the target person performs a sliding operation, the display device is used to display the parameter value of the adjusted stimulation parameter in real time;

When the target person's numerical input operation for the adjusted stimulation parameter is received by the interaction device, the input numerical value is determined as the parameter value of the adjusted stimulation parameter after adjustment.

The beneficial effect of this technical solution is that the target person is the patient himself, and the parameter value of the adjusted stimulation parameter is displayed in real time while sliding, which not only enables the patient to obtain the visualized stimulation parameter, but also The patient can know the specific numerical value corresponding to the visualized stimulation parameter; when the stimulation parameter value obtained by the patient through sliding operation is not accurate, the patient can correct the parameter value by inputting the numerical value. In summary, multiple parameter value adjustment methods are provided to the patient, and sliding operation is used as a prerequisite for inputting numerical value operation, which fully considers that touch operation is easier for patients than numerical operation, and also considers the patient's requirement for more accurate parameter value of stimulation parameter in specific situations, which is more humane.

In one embodiment, the parameter adjustment device is configured to determine the adjusted stimulation parameter and its adjusted parameter value in the following manner:

Inputting the adjusted output graph into a similarity model to output a predicted similarity corresponding to the adjusted output graph;

The similarity model is used to compare the adjusted output graphic with each sample graphic in the similarity database, respectively, to obtain the predicted similarity corresponding to the adjusted output graphic and each sample graphic, as well as the stimulation parameters and parameter values corresponding to each sample graphic, and to take the highest similarity among the multiple similarities corresponding to the adjusted output graphic as the predicted similarity corresponding to the adjusted output graphic;

When the predicted similarity is not less than a preset similarity threshold, the stimulation parameters and parameter values corresponding to the adjusted output graphics are used as the adjusted stimulation parameters and the adjusted parameter values.

The beneficial effect of this technical solution is that as long as the adjusted output graphics are input into the similarity model, the predicted similarity corresponding to the above output graphics can be obtained in real time. For example, when the number of sample graphics is large enough, the accuracy is expected to reach an extremely high level, and the degree of intelligence is high. When the high-accuracy predicted similarity obtained is not less than the preset similarity threshold, the stimulation parameters and parameter values corresponding to the adjusted output graphics are used as the adjusted stimulation parameters and parameter values. When the difference between the adjusted stimulation parameters of the target person and the stimulation parameters corresponding to all sample graphics is too large, it can be avoided that the patient may be injured or have a bad user experience. The similarity model has strong robustness and low overfitting risk, simple calculation process, fast calculation speed, high calculation efficiency, and consumes less computing resources.

In one embodiment, when the predicted similarity is less than a preset similarity threshold, the parameter adjustment device is configured to:

Using the display device to display an adjustment failure prompt message; or

The stimulation parameters and parameter values corresponding to the sample graphics with the highest similarity are used as the adjusted stimulation parameters and the adjusted parameter values.

The beneficial effects of this technical solution are: when the predicted similarity is too low (less than a preset similarity threshold), the target person can be reminded to guide the target person to perform correct parameter adjustment (sliding) operations, and gradually improve the patient's ability to adjust the stimulation parameters; the stimulation parameters and parameter values corresponding to the sample graphic with the highest similarity can also be selected as the adjusted stimulation parameters and their adjusted parameter values. On the one hand, it can be as close as possible to the target person's choice of stimulation parameters. On the other hand, when the difference between the target person's adjusted stimulation parameters and the stimulation parameters corresponding to the sample graphic is too large, it is necessary to consider that the stimulation parameters adjusted by the target person have not been verified, which may cause damage to the patient or a bad user experience. Therefore, the above-mentioned device has a high level of intelligence.

In one embodiment, the parameter value of each of the stimulation parameters is within a preset patient control range.

The beneficial effect of this technical solution is that it can avoid unreasonable parameter values of stimulation parameters adjusted by patients, causing damage to patients or causing physical discomfort to patients.

In a second aspect, the present application provides a parameter adjustment method, which is used to visually adjust stimulation parameters of a stimulator implanted in a patient's body, and the method comprises:

Using a display device to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue; wherein the output graph is used to indicate the stimulation parameters and parameter values of the electrical stimulation signal;

Displaying the adjusted output graph using the display device;

In one embodiment, the displaying of the output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue by the display device comprises: displaying a plurality of pre-set output graphs in the same display interface by the display device;

When a selection operation of the target person on one of the output graphics is received, the selected output graphics is displayed using the display device.

In one embodiment, the display device displays the output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue, including:

In one embodiment, the target person is the patient himself, and the method of determining the parameter value of the adjusted stimulation parameter after adjustment includes:

In a third aspect, the present application provides a program-controlled device, comprising a display device, an interaction device and the parameter adjustment device described in the first aspect.

In a fourth aspect, the present application provides a medical system, the medical system comprising any one of the above-mentioned program-controlled devices and a stimulator implanted in a patient;

The stimulator is configured to generate electrical stimulation and deliver the electrical stimulation to the patient.

In a fifth aspect, the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the function of any of the above-mentioned parameter adjustment devices is realized, or the steps of the method described in the second aspect are realized.

BRIEF DESCRIPTION OF THE DRAWINGS

The present application is further described below in conjunction with the accompanying drawings and embodiments.

FIG1 shows a structural block diagram of a medical system provided by the present application.

FIG2 shows a structural block diagram of a program-controlled device provided by the present application.

FIG3 shows a schematic flow chart of a parameter adjustment method provided in the present application.

FIG. 4 shows a schematic diagram of a flow chart of displaying output graphics provided by the present application.

FIG. 5 shows a schematic diagram of another flow chart of displaying output graphics provided by the present application.

FIG. 6 shows a schematic diagram of a flow chart of determining stimulation parameters and parameter values provided by the present application.

FIG. 7 shows a schematic diagram of a flow chart of determining adjusted stimulation parameters provided by the present application.

FIG. 8 shows another schematic diagram of a flow chart for determining stimulation parameters and parameter values provided by the present application.

FIG. 9 shows a schematic diagram of an output graph provided by the present application.

FIG. 10 shows a schematic diagram of another output graph provided by the present application.

FIG. 11 shows a structural block diagram of a program product provided by the present application.

Detailed ways

Below, the present application is further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

First, one of the application fields of the embodiment of the present application (i.e., an implantable neural stimulator) is briefly described.

An implantable neurostimulation system (an implantable medical system) mainly includes a stimulator implanted in the patient's body (i.e., an implantable neurostimulator) and a programmable device installed outside the patient's body. Neuromodulation technology mainly involves implanting electrodes in specific structures (i.e., targets) in the body through stereotactic surgery, and the stimulator implanted in the patient's body emits discharge pulses to the target through the electrodes to regulate the electrical activity and function of the corresponding neural structures and networks, thereby improving symptoms and relieving pain. Among them, the stimulator can be any one of an implantable neuroelectric stimulation device, an implantable cardiac electrical stimulation system (also known as a pacemaker), an implantable drug delivery system (Implantable Drug Delivery System, referred to as I DDS), and a lead switching device. Examples of implantable neural stimulation devices include the Deep Brain Stimulation (DBS) system, the Cortical Nerve Stimulation (CNS) system, the Spinal Cord Stimulation (SCS) system, the Sacral Nerve Stimulation (SNS) system, and the Vagus Nerve Stimulation (VNS) system.

The stimulator may include an IPG and an electrode lead. The IPG (implantable pulse generator) is arranged in the patient's body, receives the program-controlled instructions sent by the program-controlled device, relies on a sealed battery and a circuit to provide controllable electrical stimulation energy to the body tissue, and delivers one or two controllable specific electrical stimulations to specific areas of the body tissue through the implanted electrode lead. It can also be considered that the electrode lead includes an extension lead and a stimulation segment. The extension lead is used in conjunction with the IPG as a transmission medium for the electrical stimulation signal, and the electrical stimulation signal generated by the IPG is transmitted to the stimulation segment of the electrode lead. The electrode lead delivers electrical stimulation to specific areas of the body tissue through multiple electrode contacts of the stimulation segment. The stimulator is provided with one or more electrode leads on one side or both sides, and multiple electrode contacts are arranged on the stimulation segment of the electrode lead. The electrode contacts can be arranged uniformly or non-uniformly on the circumference of the electrode lead. As an example, the electrode contacts can be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) on the circumference of the stimulation segment of the electrode lead. The electrode contacts may include stimulation electrode contacts and/or collection electrode contacts. The electrode contacts can be in the form of sheets, rings, Shapes such as shapes, dots, etc.

In some possible embodiments, the stimulated in vivo tissue may be the patient's brain tissue, and the stimulated site may be a specific site of the brain tissue. When the patient's disease type is different, the stimulated site is generally different, and the number of stimulation contacts (single source or multiple sources) used, the use of one or more (single channel or multiple channels) specific electrical stimulation signals, and the stimulation parameter data are also different. The embodiments of the present application do not limit the applicable disease types, which may be deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. Disease types that DBS can be used to treat or manage include, but are not limited to: spastic diseases (e.g., epilepsy), pain, migraine, mental illness (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety, post-traumatic stress disorder, mild depression, obsessive-compulsive disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism or other neurological or psychiatric diseases and damage.

In the embodiment of the present application, when the programmable device and the stimulator establish a programmable connection, the programmable device can be used to adjust the stimulation parameters of the stimulator (different stimulation parameters correspond to different electrical stimulation signals), or the stimulator can be used to sense the bioelectric activity deep in the patient's brain to collect electrophysiological signals, and the collected electrophysiological signals can be used to continue to adjust the stimulation parameters of the stimulator's electrical stimulation signals.

Stimulation parameters may include one or more of the following: frequency (for example, the number of electrical stimulation pulse signals within a unit time of 1s, in Hz), pulse width (duration of each pulse, in μs), amplitude (generally expressed in voltage, that is, the intensity of each pulse, in V), timing (for example, it can be continuous or burst, and burst refers to a timing behavior composed of multiple processes and not continuous), upper and lower limits controlled by the doctor (the range that the doctor can adjust) and upper and lower limits controlled by the patient (the range that the patient can adjust independently), and waveform (sine wave, square wave).

In a specific application scenario, various stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

The program-controlled device may be a doctor program-controlled device (i.e., a program-controlled device used by a doctor) or a patient program-controlled device (i.e., a program-controlled device used by a patient). The doctor program-controlled device may be, for example, a tablet computer, a laptop computer, a desktop computer, a mobile phone or other intelligent terminal device equipped with program-controlled software. The patient program-controlled device may be, for example, a tablet computer, a laptop computer, a desktop computer, a mobile phone or other intelligent terminal device equipped with program-controlled software. The patient program-controlled device may also be other electronic devices with program-controlled functions (e.g., a charger with program-controlled functions, a data acquisition device).

The embodiment of the present application does not restrict the data interaction between the doctor's programmable device and the stimulator. When the doctor performs remote programming, the doctor's programmable device can interact with the stimulator through the server and the patient's programmable device. When the doctor performs offline programming with the patient face to face, the doctor's programmable device can interact with the stimulator through the patient's programmable device, and the doctor's programmable device can also interact with the stimulator directly.

In one embodiment, the patient programmable device may include a host (communicating with a server) and a slave (communicating with a stimulator), and the host and the slave are communicably connected. The doctor programmable device may exchange data with the server via a 3G/4G/5G network, the server may exchange data with the host via a 3G/4G/5G network, the host may exchange data with the slave via a Bluetooth protocol/WIFI protocol/USB protocol, and the slave may communicate with the stimulator via a 401MHz-406MHz operating frequency band/2.4GHz-2.48GHz operating frequency band. To interact with the stimulator, the doctor's programmable device can directly interact with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band.

(Medical System Embodiment)

Referring to FIG. 1 , FIG. 1 shows a structural block diagram of a medical system 100 provided in the present application.

The medical system 100 includes a program-controlled device 110 and a stimulator 120 implanted in a patient;

The stimulator 120 is configured to generate electrical stimulation and deliver the electrical stimulation to the patient.

(Program-controlled device embodiment)

Referring to FIG. 2 , FIG. 2 shows a structural block diagram of a program-controlled device 110 provided in the present application.

The program-controlled device 110 includes a display device 111 , an interaction device 113 and a parameter adjustment device 112 .

This embodiment does not limit the type of display device 111. The display device 111 may include a display, such as a liquid crystal display (LCD), a light emitting diode (LED)-based display, a flat-panel display, a curved screen, a television device, a cathode ray tube (CRT), a touch screen, etc., or a combination of several of them, to display information related to the stimulation therapy. The display device 111 may display output graphics, and may also display operation controls for the output graphics, such as "OK" and "Cancel" operation controls, for receiving the patient's confirmation or cancellation operation after adjusting the output graphics.

In the embodiment of the present application, the parameter adjustment device 112 can be configured to implement the steps of a parameter adjustment method, and the parameter adjustment method will be described below.

(Parameter adjustment method embodiment)

Referring to FIG. 3 , FIG. 3 shows a flow chart of a parameter adjustment method provided in the present application.

The parameter adjustment method is used to visually adjust stimulation parameters of a stimulator implanted in a patient's body, and the method comprises:

Step S101: using a display device to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's body tissue; wherein the output graph is used to indicate stimulation parameters and parameter values of the electrical stimulation signal;

Step S102: when the target person's adjustment operation on the output graphic is received by the interactive device, the adjusted stimulation parameter and the adjusted parameter value are determined;

Step S103: using the display device to display the adjusted output graph;

Step S104: when a confirmation operation for the output graphic is received by the interactive device, the stimulator is used to deliver electrical stimulation corresponding to the adjusted output graphic to the patient.

Therefore, the output graph of the electrical stimulation signal is displayed using a display device, which is different from the related art where the display device only displays the output numerical value. This can help medical staff and non-medical patients intuitively understand the relationship between the stimulation parameters and the electrical stimulation signal; directly adjust the output graph to visualize (graphicalize) the adjusted stimulation parameters and parameter values, which is different from the related art where the parameter values of the stimulation parameters are adjusted. This allows the target person to visualize the stimulation parameter adjustment of the stimulator, so that the impact of the stimulation parameter adjustment on the electrical stimulation of the patient's body tissue can be more intuitively understood. It can be understood that the stimulation parameters and their parameter values are displayed in the output graph, and the electrical stimulation signal corresponding to the displayed output graph is delivered to the patient at the same time; the target person can use the interactive device to directly adjust the stimulation parameters and parameter values of the electrical stimulation signal indicated by the output graph, and use the display device to display the output graph after adjusting the parameter values in real time, and at the same time deliver the adjusted output graph to the patient in real time. The electrical stimulation corresponding to the stimulation parameters and parameter values thereof. On the one hand, before the target person adjusts the stimulation parameters and parameter values, the stimulator performs electrical stimulation treatment on the patient according to the original stimulation parameters and parameter values, so that the target person can compare the effect after adjustment with the effect before adjustment, shorten the time length for the target person to find the electrical stimulation suitable for the current stage, and enable the target person to master how to adjust the stimulation parameters of the stimulator more quickly and accurately; on the other hand, when the target person is the patient himself, when the stimulator delivers the electrical stimulation corresponding to the adjusted output graph to the patient, the display device displays the adjusted output graph in real time (which can be understood as an update of the output graph), and when the patient feels that the adjusted electrical stimulation causes physical discomfort, the patient can further adjust the updated output graph in real time. Since the output graph is updated in real time, the patient has a more intuitive understanding of the adjustment of the output graph (stimulation parameters) at the first time, which improves the efficiency of the patient's parameter adjustment of the stimulator; on the other hand, the output graph can be used to indicate the stimulation parameters and parameter values of the electrical stimulation signal, which can more intuitively reflect the characteristics of the output waveform of the electrical stimulation, so that the target person can adjust the parameter values of the stimulation parameters more intuitively.

This embodiment does not limit the types of stimulation parameters. In a specific application, the stimulation parameters may include one or more of frequency, pulse width, amplitude and timing, which can satisfy the target person's adjustment of part or all of the stimulation parameters of the delivered electrical stimulation, such as adjusting the timing from continuous to burst, thereby alleviating the discomfort caused to the patient by continuous stimulation and improving the effect of electrical stimulation on the patient.

This embodiment does not limit the type of interactive device, and the interactive device may include one or a combination of keyboard, mouse, touch screen, to enable the patient to interact with the output graphics. When the interactive device is a keyboard, mouse, or touch screen, the interactive device can be integrated in a display device. In a specific application, the adjusted output graphics are displayed using the display device in real-time step S103, and the output graphics before adjustment can be displayed while displaying the adjusted output graphics. The output graphics before adjustment and the output graphics after adjustment can be arranged side by side in the display device, so that the patient can compare the two output graphics before and after the stimulation parameter adjustment.

The output graph is, for example, a line graph or a bar graph. When the output graph is a bar graph, the horizontal axis of the bar graph may be a time axis, the vertical axis may be an amplitude axis, and there are multiple bars arranged continuously or discontinuously along the time axis on the output graph. The number of bars in a unit time (e.g., within 1 second) may represent the frequency, the duration of each bar on the time axis may represent the pulse width, and the length of each bar on the vertical axis may represent the amplitude. Multiple bars arranged continuously and at equal intervals represent that the timing sequence is continuous, and multiple bars with discontinuous timing sequence behavior represent that the timing sequence is bursted.

The target person can be a medical staff or non-medical staff, or the patient himself. Generally speaking, the doctor usually adjusts the stimulation parameters of the stimulator in the patient's body in the early stage of implanting the stimulator. After a period of treatment, the patient's condition may change while receiving the stimulation treatment of the stimulator, and the stimulation parameters applied to the patient need to be changed to maintain the treatment effect. It is impossible for the patient to always have a professional doctor around to monitor and treat in real time, so the patient can be allowed to adjust the stimulation parameters of the stimulator to a certain extent. For example, the patient is allowed to select any stimulation parameter (such as amplitude) and then enter a new parameter value. Since the patients who use implantable medical devices are all patients with mental illness or other neurological or psychiatric diseases and injuries, the above patients cannot reach the attention level of normal people. When using conventional stimulation parameter adjustment devices to adjust the stimulation parameters, it is easy to make input errors, causing discomfort or damage to the patients.

In a specific application, the target person is the patient himself. Since the stimulators are used by patients with mental illness or other neurological or psychiatric diseases and injuries, the above patients are fighting against the disease all the time and cannot reach the attention level of normal people. Different from the reference parameter adjustment method in the related technology that can be easily achieved by normal people (for example, selecting amplitude options with a mouse and entering amplitude data with a keyboard, the above patients are prone to multiple or insufficient input digits when using the devices of the related technology, which may cause discomfort or injury to the patients), the stimulation parameter adjustment is visualized, and the output graph that can more intuitively reflect the output waveform characteristics of the electrical stimulation is used as the patient's adjustment object, so that the patient has a more intuitive understanding of the stimulation parameters of the stimulator and intuitive adjustment operations, which improves the effect of parameter adjustment and reduces the possibility of discomfort or injury to the patient when adjusting the stimulation parameters and their parameter values.

In one embodiment, the stimulation parameters include at least two of frequency, pulse width, amplitude and timing. The same output graph indicates multiple stimulation parameters of the electrical stimulation signal. The target person can adjust multiple stimulation parameters through one output graph. The output graph only indicates the electrical stimulation signal corresponding to one stimulation parameter, which increases the data volume of the output graph. The patient can conveniently adjust multiple stimulation parameters at the same time, and the electrical stimulations corresponding to the multiple adjusted stimulation parameters can be delivered to the patient at the same time, so that the patient can feel the impact of the multiple adjusted stimulation parameters on the stimulation therapy in real time, and can find the combination of stimulation parameters and values suitable for the current stage more quickly, thereby improving the efficiency and accuracy of the patient in adjusting the stimulation parameters.

In one specific application, the output graph is a bar graph, and the stimulation parameters indicated by the output graph include frequency, pulse width, amplitude and timing; in another specific application, the output graph is a line graph, and the stimulation parameters indicated by the output graph include amplitude and timing.

In a specific application, a display device is used to display the output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue. The output graph may be multiple electrical stimulation signals corresponding to different (groups of) electrode contacts. The patient may also be allowed to adjust the output graph of each or each group of electrode contacts individually.

In one embodiment, step S101 may include:

Step S201: using the display device to display a plurality of pre-set output graphics in the same display interface;

Step S202: When a selection operation of the target person on one of the output graphics is received, the selected output graphic is displayed using the display device.

Thus, multiple pre-set output graphics are displayed in the same display interface, and the target person can obtain information about the multiple output graphics without changing pages, which is convenient for the target person to compare and select the preset output graphics; when the target person is the patient himself, the display device displays the output graphics selected by the patient, which can reflect the patient's own reception degree of different electrical stimulation signals of the stimulator. Because the target person who adjusts the displayed output graphics is the patient himself, the patient's participation in the parameter adjustment process is improved.

In summary, in the same display interface, any pre-set output graphic is selected as the output graphic to be displayed. The difficulty for the target person to select the output graphics corresponding to the stimulation parameters and the patient's participation in the parameter adjustment process are reduced.

Among them, the pre-set output graph can correspond to the stimulation parameter mode pre-set by the doctor, such as "first mode", "second mode", etc. The stimulation parameters and parameter values in different stimulation parameter modes may be completely different or partially different. For example, the output graph in the first mode is shown in Figure 9, the ordinate represents the amplitude, the unit is V, the abscissa represents the time, the unit is 60μs, and the corresponding stimulation parameters and parameter values are "continuous pulse stimulation with a pulse width of 60μs and an amplitude of -2.2V". For example, the output graph in the second mode is shown in Figure 10, the ordinate represents the amplitude, the unit is V, the abscissa represents the time, the unit is 10 ⁶ μs (seconds), and the corresponding stimulation parameters and parameter values are "the timing is burst, the abscissa is between 0 and the 1st minute, and between the 2nd minute and the 3rd minute, and there is no pulse stimulation in the omitted part between the 1st minute and the 2nd minute of the abscissa".

The target person's selection operation on one of the output graphics may be a selection operation by the target person from a plurality of pre-set output graphics through an interactive device, such as double-clicking any pre-set output graphic with a mouse, dragging any pre-set output graphic through a touch screen, or screening out output graphics other than any pre-set output graphic.

In one embodiment, the target person is the patient himself, and the parameter value of the adjusted stimulation parameter after adjustment can be determined in the following manner:

Thus, the parameter value of a stimulation parameter in the output graph can be adjusted through the trajectory of the patient's sliding operation, so as to reduce the difficulty for the patient to adjust the parameter value of the stimulation parameter using the interactive device. Because the patient's ability to operate the output graph cannot be compared with that of a normal person, the above setting is considered from the perspective of the patient's actual operation. Not only will the patient not feel irritated because the sliding operation can only adjust the parameter value of one stimulation parameter, but the patient will feel the humanized setting in the process of adjusting the stimulation parameter, so as to encourage the patient to cooperate with the stimulation treatment of the stimulator.

In one embodiment, step S101 may further include:

Step 203: using the display device to display a plurality of pre-set output graphics in the same display interface;

Step 204: When a selection operation of the target person on one of the output graphics is received, the selected output graphic and its corresponding reference graphic are displayed simultaneously by the display device.

Thus, multiple preset output graphics are displayed in the same display interface, and the target person can obtain information of multiple output graphics without changing pages, which is convenient for the target person to compare and select preset output graphics; selecting any preset output graphic as the displayed output graphic in the same display interface reduces the difficulty for the target person to select the output graphic corresponding to the stimulation parameters and the patient's participation in the parameter adjustment process; when the target person selects any output graphic, the display device displays the selected output graphic, and the display device also displays the reference graphic corresponding to the selected output graphic, which is convenient for medical staff and others to refer to the reference graphic Adjust the currently selected output graph to improve the accuracy of adjusting the patient stimulator parameters.

The reference graph may include: output graphs of one or more electrodes other than the electrode corresponding to the currently selected output graph, that is, the reference graph may represent the stimulation parameters of other electrodes at present, or represent the optimal stimulation parameters of other electrodes selected by the doctor. The reference graph may also represent the output graph pre-set for the electrode corresponding to the selected output graph, which may be the output graph pre-set and entered by the doctor for the current electrode according to the patient's previous condition, or the output graph collected by the target person himself.

In one embodiment, step S102 may include:

Step S301: obtaining the corresponding relationship between the sliding operation and the stimulation parameters;

Step S302: determining the adjusted stimulation parameters based on the sliding operation and the corresponding relationship.

As a result, patients do not need to memorize complicated operating instructions or enter data through the keyboard. They only need to perform simple sliding operations (up and down or left and right). Through the simple correspondence between the sliding operation and the stimulation parameters, the amplitude and pulse width parameters can be adjusted. This allows more patients with physical disabilities to use the above parameter adjustment method to achieve visual stimulation parameter adjustment of the stimulator in the body.

In one embodiment, the parameter value of the adjusted stimulation parameter after adjustment can also be determined in the following manner: using an interactive device to receive a sliding operation of the target person on the output graphic, and adjusting the parameter values of multiple stimulation parameters of the output graphic along the trajectory of the sliding operation to determine the parameter value of the adjusted stimulation parameter after adjustment.

For example, when the output graph is a bar graph, the horizontal axis of the bar graph is the time axis, the vertical axis is the amplitude axis, and there are multiple bars arranged continuously or discontinuously along the time axis on the output graph. The duration of each bar on the time axis represents the pulse width, and the length of each bar on the vertical axis can represent the amplitude. The patient can slide any bar to increase its length and reduce its width in the direction of the time axis, so as to reduce the pulse width and increase the amplitude of the stimulation parameter indicated by the current bar. In other words, two stimulation parameters can be adjusted at one time through a single sliding operation.

In this way, some patients in good physical condition can be satisfied and the parameter value adjustment of the stimulation parameters can be achieved more quickly.

In one embodiment, step S302 may include:

Step S401: while the target person performs a sliding operation, using the display device to display the parameter value of the adjusted stimulation parameter in real time;

Step S402: when the target person's numerical input operation for the adjusted stimulation parameter is received by the interactive device, the input numerical value is determined as the adjusted parameter value of the adjusted stimulation parameter.

Therefore, the target person is the patient himself, and the parameter value of the adjusted stimulation parameter is displayed in real time while sliding, so that the patient can not only obtain the visualized stimulation parameter, but also know the specific value corresponding to the visualized stimulation parameter; when the parameter value of the stimulation parameter obtained by the patient through the sliding operation is not accurate, the patient can correct the parameter value by inputting the value. In summary, a variety of parameter values are provided to the patient The invention adopts an adjustment method and takes sliding operation as a prerequisite for inputting numerical operation, which fully considers that touch operation is easier for patients than numerical operation, and also considers the patient's requirement for more precise parameter values of stimulation parameters in specific situations, which is more humane.

In one embodiment, the step S102 may further include:

Step S501: inputting the adjusted output graph into a similarity model to output a predicted similarity corresponding to the adjusted output graph;

The similarity model is used to compare the adjusted output graphic with each sample graphic in the similarity database, obtain the predicted similarity corresponding to the adjusted output graphic and each sample graphic, and the stimulation parameters and parameter values corresponding to each sample graphic, and take the highest similarity among the multiple similarities corresponding to the adjusted output graphic as the predicted similarity corresponding to the adjusted output graphic;

Step S502: when the predicted similarity is not less than a preset similarity threshold, the stimulation parameters and parameter values corresponding to the adjusted output graphics are used as the adjusted stimulation parameters and the adjusted parameter values.

Therefore, as long as the adjusted output graphics are input into the similarity model, the predicted similarity corresponding to the above output graphics can be obtained in real time. For example, when the number of sample graphics is large enough, the accuracy is expected to reach an extremely high level, and the degree of intelligence is high. When the high-accuracy predicted similarity obtained is not less than the preset similarity threshold, the stimulation parameters and parameter values corresponding to the adjusted output graphics are used as the adjusted stimulation parameters and parameter values. This can avoid the situation where the stimulation parameters adjusted by the target person and the stimulation parameters corresponding to all sample graphics are too different, which may cause damage to the patient or a bad user experience. The similarity model has strong robustness and low overfitting risk, simple calculation process, fast calculation speed, high calculation efficiency, and consumes less computing resources.

The preset similarity threshold may be a threshold preset by a doctor, such as 95%, 85% or 0.98. The training process of the similarity model may include, for example: obtaining a training set, the training set including a plurality of training data, each of the training data including a first sample graphic, a second sample graphic, and annotated data of the similarity between the first sample graphic and the second sample graphic, and may also include stimulation parameters and parameter values corresponding to the first sample graphic, and stimulation parameters and parameter values corresponding to the second sample graphic;

For each training data in the training set, perform the following processing:

Inputting the first sample graph and the second sample graph in the training data into a preset deep learning model to obtain prediction data of the similarity between the first sample graph and the second sample graph;

Based on the prediction data and the annotation data of the similarity between the first sample graph and the second sample graph, updating the model parameters of the deep learning model;

Check whether the preset training end condition is met; if so, use the trained deep learning model as the similarity model; if not, continue to train the deep learning model using the next training data.

The present application does not limit the training process of the similarity model, which may adopt, for example, a supervised learning training method, a semi-supervised learning training method, or an unsupervised learning training method.

The present application does not limit the preset training end conditions, which may be, for example, the number of training times reaches a preset number (the preset number of times may be, for example, 1 time, 3 times, 10 times, 100 times, 1000 times, 10000 times, etc.), or the training data in the training set has completed one or more trainings, or the total loss value obtained from this training is not greater than the preset loss value.

The present application does not limit the preset similarity threshold, which may be, for example, 81%, 83%, 92%, 95%, 99.9%, etc.

In one embodiment, when the predicted similarity is less than a preset similarity threshold, the method may include the steps of:

The display device is used to display an adjustment failure prompt message; or the stimulation parameter and parameter value corresponding to the sample pattern with the highest similarity are used as the adjusted stimulation parameter and the adjusted parameter value.

Therefore, when the predicted similarity is too low (less than the preset similarity threshold), the target person can be reminded to guide the target person to perform the correct parameter adjustment (sliding) operation, and gradually improve the patient's ability to adjust the stimulation parameters; the stimulation parameters and parameter values corresponding to the sample graphic with the highest similarity can also be selected as the adjusted stimulation parameters and their adjusted parameter values. On the one hand, it can be as close as possible to the target person's choice of stimulation parameters. On the other hand, when the difference between the stimulation parameters adjusted by the target person and the stimulation parameters corresponding to the sample graphic is too large, it is necessary to consider that the stimulation parameters adjusted by the target person have not been verified, which may cause damage to the patient or a bad user experience. Therefore, the above-mentioned device has a high level of intelligence.

Among them, the adjustment failure prompt information displayed by the display device can be a pop-up window prompt or a voice prompt, for example, a pop-up window "Hello patient Zhang San, the stimulation parameter adjustment failed this time, please try again or contact medical staff for help."

In some optional real-time modes, the parameter value of each of the stimulation parameters is within a preset patient control range.

In this way, it can be avoided that the parameter values of the stimulation parameters adjusted by the patient are unreasonable, causing damage to the patient or causing physical discomfort to the patient.

The patient control range includes, for example, an amplitude of -3V to 3V, a frequency of 60Hz to 140Hz, a timing of continuous, a pulse width of 1μs to 100μs, and the like.

In one embodiment, the parameter adjustment device is configured to display the adjusted output graph using the display device in the following manner:

When a confirmation operation of the patient on the output graphic is received within a preset time period, the adjusted output graphic is displayed on the display device; or when no operation of the patient on the output graphic is received within the preset time period, the adjusted output graphic is displayed on the display device after the preset time period ends.

Therefore, as long as the patient's confirmation operation is received within the preset time, the adjusted output graph will be displayed on the display device, and the target person can operate simply; when the target person does not cancel the output graph within the preset time, the adjusted output graph will be displayed on the display device, so that some target persons (patients) with poor physical conditions and slow operations can also use the above-mentioned parameter adjustment method to visually adjust the stimulation parameters of the stimulator.

(Device Example)

The present application also provides a parameter adjustment device, the specific implementation method of which is consistent with the implementation method and the technical effect achieved in the above-mentioned method implementation method, and some contents will not be repeated here.

The parameter adjustment device is used to visually adjust stimulation parameters of a stimulator implanted in a patient's body, and the parameter adjustment device includes a processor, and the processor is configured to implement the following steps:

Displaying the adjusted output graph using the display device;

In one embodiment, the parameter adjustment device is configured to determine the adjusted parameter in the following manner: The stimulation parameters and their adjusted parameter values are as follows:

Using the display device to display an adjustment failure prompt message; or

(Medium Embodiment)

The embodiment of the present application also provides a computer-readable storage medium, and its specific implementation method is consistent with the implementation method and the technical effect achieved in the above method embodiment, and some contents will not be repeated here.

The computer-readable storage medium is used to store a computer program; when the computer program is executed, the steps of the above method in the embodiment of the present application are implemented.

Referring to FIG. 11 , FIG. 11 shows a block diagram of a program product provided by the present application. It can adopt a portable compact disk read-only memory (CD-ROM) and include program code, and can be run on a terminal device, such as a personal computer. However, the program product of the present invention is not limited to this. In this document, a readable storage medium can be any tangible medium containing or storing a program, which can be used by an instruction execution system, device or device or used in combination with it. The program product can adopt any combination of one or more readable media. The readable medium can be a readable signal medium or a readable storage medium. The readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of readable storage media (non-exhaustive list) include: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above.

Computer-readable storage media may include data signals propagated in baseband or as part of a carrier wave, which carry readable program code. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The readable storage medium may also be any readable medium other than a readable storage medium, which may send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device. The program code contained on the readable storage medium may be transmitted using any appropriate medium, including but not limited to wireless, wired, optical cable, RF, etc. Etc., or any suitable combination thereof. The program code for performing the operation of the present invention may be written in any combination of one or more programming languages, including object-oriented programming languages such as Java, C++, etc., and also conventional procedural programming languages such as "C" language or similar programming languages. The program code may be executed entirely on the user computing device, partially on the user device, as an independent software package, partially on the user computing device, partially on the remote computing device, or entirely on the remote computing device or server. In the case of a remote computing device, the remote computing device may be connected to the user computing device via any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computing device (e.g., using an Internet service provider to connect via the Internet).

It should be noted that, in the embodiments of the present application, "at least one" refers to one or more, and "multiple" refers to two or more. "And/or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and/or B can represent: A exists alone, A and B exist at the same time, and B exists alone, where A and B can be singular or plural. The character "/" generally indicates that the associated objects before and after are in an "or" relationship. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items. For example, at least one of a, b or c can represent: a, b, c, a and b, a and c, b and c or a and b and c, where a, b and c can be single or multiple. It is worth noting that "at least one" can also be interpreted as "one or more items".

In the embodiments of the present application, the words "exemplary" or "for example" are used to indicate examples, illustrations or descriptions. Any embodiment or design described as "exemplary" or "for example" in the present application should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Specifically, the use of words such as "exemplary" or "for example" is intended to present related concepts in a specific way.

The terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are configured to distinguish similar objects, and need not be configured to describe a specific order or sequential order. It should be understood that the data used in this way can be interchangeable in appropriate circumstances, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, the process, method, system, product or equipment comprising a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or equipment.

Claims

A parameter adjustment device, the parameter adjustment device is used to visually adjust stimulation parameters of a stimulator implanted in a patient's body, the parameter adjustment device comprises a processor, and the processor is configured to implement the following steps:

Displaying, by means of a display device, an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue, wherein the output graph is used to indicate stimulation parameters and parameter values of the electrical stimulation signal;

When an adjustment operation of the target person on the output graphic is received by the interactive device, determining the adjusted stimulation parameter and the adjusted parameter value;

Displaying the adjusted output graph using the display device;

When a confirmation operation for the output pattern is received by the interaction device, the stimulator is used to deliver electrical stimulation corresponding to the adjusted output pattern to the patient.
The parameter adjustment device according to claim 1, wherein the parameter adjustment device is configured to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue using a display device in the following manner:

Using the display device to display a plurality of pre-set output graphics in the same display interface;

When a selection operation of the target person on one of the output graphics is received, the selected output graphics is displayed using the display device.
The parameter adjustment device according to claim 1, wherein the parameter adjustment device is configured to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue using a display device in the following manner:

Using the display device to display a plurality of pre-set output graphics in the same display interface;

When a selection operation of the target person on one of the output graphics is received, the selected output graphic and its corresponding reference graphic are displayed simultaneously by the display device.
The parameter adjustment device according to claim 1, wherein the target person is the patient himself, and the parameter adjustment device is configured to determine the adjusted parameter value of the adjusted stimulation parameter in the following manner:

An interactive device is used to receive a sliding operation of the target person on the output graphic, and a parameter value of one of the stimulation parameters of the output graphic is adjusted along a trajectory of the sliding operation to determine a parameter value of the adjusted stimulation parameter after adjustment.
The parameter adjustment device according to claim 4, wherein the parameter adjustment device is configured to determine the adjusted stimulation parameters in the following manner:

Obtaining the corresponding relationship between the sliding operation and the stimulation parameters;

Based on the sliding operation and the corresponding relationship, determining the adjusted stimulation parameter;

Among them, the sliding direction of the up and down direction corresponds to the amplitude, and the sliding direction of the left and right direction corresponds to the pulse width.
The parameter adjustment device according to claim 4, wherein the parameter adjustment device is configured to determine the parameter value of the adjusted stimulation parameter after adjustment in the following manner:

When the target person performs a sliding operation, the display device is used to display the adjusted parameter values of stimulus parameters;

When the target person's numerical input operation for the adjusted stimulation parameter is received by the interaction device, the input numerical value is determined as the parameter value of the adjusted stimulation parameter after adjustment.
The parameter adjustment device according to claim 1, wherein the parameter adjustment device is configured to determine the adjusted stimulation parameter and its adjusted parameter value in the following manner:

Inputting the adjusted output graph into a similarity model to output a predicted similarity corresponding to the adjusted output graph;

The similarity model is used to compare the adjusted output graphic with each sample graphic in the similarity database, respectively, to obtain the predicted similarity corresponding to the adjusted output graphic and each sample graphic, as well as the stimulation parameters and parameter values corresponding to each sample graphic, and to take the highest similarity among the multiple similarities corresponding to the adjusted output graphic as the predicted similarity corresponding to the adjusted output graphic;

When the predicted similarity is not less than a preset similarity threshold, the stimulation parameters and parameter values corresponding to the adjusted output graphics are used as the adjusted stimulation parameters and the adjusted parameter values.
The parameter adjustment device according to claim 7, wherein when the predicted similarity is less than a preset similarity threshold, the parameter adjustment device is configured to:

Using the display device to display an adjustment failure prompt message; or

The stimulation parameters and parameter values corresponding to the sample graphics with the highest similarity are used as the adjusted stimulation parameters and the adjusted parameter values.
The parameter adjustment device according to claim 1, wherein the parameter value of each of the stimulation parameters is within a preset patient control range.
A parameter adjustment method, the parameter adjustment method is used to visually adjust stimulation parameters of a stimulator implanted in a patient's body, the method comprising:

Using a display device to display an output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue; wherein the output graph is used to indicate the stimulation parameters and parameter values of the electrical stimulation signal;

When an adjustment operation of the target person on the output graphic is received by the interactive device, determining the adjusted stimulation parameter and the adjusted parameter value;

Displaying the adjusted output graph using the display device;

When a confirmation operation for the output pattern is received by the interaction device, the stimulator is used to deliver electrical stimulation corresponding to the adjusted output pattern to the patient.
The parameter adjustment method according to claim 10, wherein the displaying of the output graph of the electrical stimulation signal delivered by the stimulator to the in vivo tissue of the patient by the display device comprises: displaying a plurality of pre-set output graphs in the same display interface by the display device;

When a selection operation of the target person on one of the output graphics is received, the selected output graphics is displayed using the display device.
The parameter adjustment method according to claim 10, wherein the display device displays the output graph of the electrical stimulation signal delivered by the stimulator to the patient's internal tissue, comprising:

Using the display device to display a plurality of pre-set output graphics in the same display interface;

When a selection operation of the target person on one of the output graphics is received, the selected output graphics and its corresponding reference graphics are simultaneously displayed by the display device.
According to the parameter adjustment method of claim 10, wherein the target person is the patient himself, the method of determining the parameter value of the adjusted stimulation parameter after adjustment comprises:

An interactive device is used to receive a sliding operation of the target person on the output graphic, and a parameter value of one of the stimulation parameters of the output graphic is adjusted along a trajectory of the sliding operation to determine a parameter value of the adjusted stimulation parameter after adjustment.
A program-controlled device comprises a display device, an interaction device and the parameter adjustment device according to claims 1-9.
A medical system comprising the programmable device of claim 14 and a stimulator implanted in a patient;

The stimulator is configured to generate electrical stimulation and deliver the electrical stimulation to the patient.
A computer-readable storage medium storing a computer program, wherein the computer program, when executed by a processor, implements the function of the parameter adjustment device according to any one of claims 1 to 9, or implements the steps of the method according to any one of claims 10 to 13.