WO2024060815A1

WO2024060815A1 - High-pressure apparatus for medical material treatment

Info

Publication number: WO2024060815A1
Application number: PCT/CN2023/108403
Authority: WO
Inventors: 舩本诚一; 张永巍
Original assignee: 舩本诚一; 张永巍
Priority date: 2022-09-22
Filing date: 2023-07-20
Publication date: 2024-03-28
Also published as: CN218059021U

Abstract

The present application relates to the field of medical material preparation. Particularly disclosed is a high-pressure apparatus for medical material treatment. The high-pressure apparatus comprises a pressure bin configured for holding a medical material and/or a raw material for the preparation of the medical material. At least one through groove is formed in a side wall of the pressure bin in a penetrating mode. The high-pressure apparatus further comprises a sealing assembly configured for sealing the through groove. The pressure bin is connected to a fluid filling assembly. A temperature adjusting assembly is arranged on the pressure bin. According to the present application, the pressure bin can be conveniently and fast pressurized, such that high-pressure treatment on the medical material is realized. By means of the temperature adjusting assembly of the present application, when the temperature in the pressure bin is too high or too low, the temperature of a fluid medium in the pressure bin can be adjusted in time, such that a pressurizing treatment effect on the medical material is improved.

Description

A high-pressure equipment for medical material processing

Technical field

The present application relates to the field of medical material preparation, and in particular to a high-pressure equipment for medical material processing.

Background technique

Medical materials include biomedical materials, etc. Biomedical materials usually refer to a type of natural or artificial materials that are used to contact and interact with living systems and can diagnose, treat, replace, repair or induce regeneration of their cells, tissues and organs. Synthetic special functional materials.

In the preparation or use of medical materials, high-pressure treatment is a common operation method. On the one hand, high-pressure treatment can be used to sterilize medical materials during the preparation or use; on the other hand, during the preparation of some medical materials, such as decellularized tissues, high pressure can also be used to sterilize the raw materials for the preparation of decellularized tissues. That is, biological tissue undergoes cell removal.

Medical materials are one of the most important materials in the medical field. The preparation and use of medical materials have received extensive attention and great importance. High pressure treatment is a relatively important operation method in the preparation or use of medical materials. Therefore, it is very important to design a high pressure device that can perform good high pressure treatment on medical materials or raw materials for the preparation of medical materials during the preparation or use of medical materials.

Utility model content

In order to perform good high-pressure treatment on medical materials or raw materials for preparing medical materials, this application provides a high-pressure equipment for medical material processing.

The high-pressure equipment for medical material processing provided in this application adopts the following technical solution:

A high-pressure device for processing medical materials, comprising a pressure chamber for placing medical materials and/or raw materials for preparing medical materials, wherein at least one through groove is penetrated through the side wall of the pressure chamber, the high-pressure device also comprises a sealing assembly for closing the through groove, and the pressure chamber is connected to a fluid filling assembly.

By adopting the above technical solution, after the pressure chamber is filled with fluid medium, the volume of the pressure chamber remains unchanged, and the fluid filling assembly is used to continue filling the pressure chamber with fluid medium, so that the medical materials and medical materials placed in the pressure chamber can be filled. /or the raw materials for the preparation of medical materials are subjected to ultra-high hydrostatic pressure treatment, so that the medical materials and/or the raw materials for the preparation of medical materials can receive sufficient and uniform pressure effects.

Optionally, the fluid filling assembly includes a fluid storage tank and a filling pipe. One end of the filling pipe is connected to the pressure chamber, and the other end of the filling pipe passes through a fluid pump and the fluid storage tank. Connection, the filling pipe is provided with a first control valve at a position between the fluid pump and the pressure chamber, and a pressure balance member is also provided on the pressure chamber.

Optionally, the pressure chamber is provided with a temperature adjustment component.

By adopting the above technical solution, since the temperature of the fluid medium may easily fluctuate during the pressure change process, and the temperature generally has an important influence on the performance of medical materials or raw materials for the preparation of medical materials, the temperature regulating component regulates the temperature of the fluid medium when the temperature of the fluid medium rises or falls, so that the temperature of the fluid medium is appropriate during the high-pressure treatment process, thereby improving the performance of the final medical material.

Optionally, the temperature regulating assembly includes a regulating fluid box for storing cold fluid or hot fluid. The regulating fluid box is connected to a communication pipe, and the communication pipe is connected to the fluid storage tank through a power pump. A first temperature detector is provided in the pressure chamber.

By adopting the above technical solution, after the first temperature detector detects the abnormal temperature of the fluid medium in the pressure chamber, the power pump can be controlled through the automatic control system, so that the fluid medium in the regulated fluid tank enters the fluid storage tank, thereby The two fluid media are mixed to neutralize the temperature, the fluid medium of appropriate temperature is added to the pressure chamber, and the temperature of the fluid medium in the pressure chamber is adjusted, which is convenient and quick.

Optionally, a second temperature detector is provided in the fluid storage tank.

By adopting the above technical solution, on the one hand, the second temperature detector detects the temperature of the fluid medium in the fluid storage tank in real time, and can control the amount of fluid medium added to the fluid storage tank, thereby more accurately controlling the temperature of the fluid medium in the fluid storage tank. Fluid medium temperature is used to control the temperature of the fluid medium entering the pressure chamber. On the other hand, based on preliminary experiments, the temperature fluctuations of the fluid medium in the pressure chamber during the pressurization process are calculated according to the corresponding pressurization conditions, and then the temperature of the fluid medium in the fluid storage tank is directly controlled by controlling the temperature of the fluid in the fluid storage tank. It is convenient and quick to offset the temperature change difference of the pressure chamber during the pressurization process.

Optionally, the temperature adjustment assembly includes a neutralization tube connected to the pressure chamber. A fourth control valve is provided on the wall of the neutralization tube extending out of the pressure chamber. A third temperature detector is provided in the pressure chamber.

By adopting the above technical solution, the third temperature detector detects the temperature in the pressure chamber. Once the temperature in the pressure chamber is abnormal, a fluid medium of appropriate temperature is added directly through the neutralization tube to neutralize and regulate the fluid in the pressure chamber. medium temperature.

Optionally, the sealing assembly includes a first sealing head, the first sealing head is inserted into the through groove and abuts against the groove wall of the through groove, and the first sealing head is connected to a first driving member for driving the first sealing head to move.

Optionally, there are two through grooves, and the sealing assembly includes a second sealing head and an adjustment plug. The second sealing head is inserted into one of the through grooves and abuts against the wall of the through groove, The second sealing head is connected to a second driving member for driving the second sealing head to slide; the regulating plug extends into the pressure chamber through another through groove, and the regulating plug and the through groove The groove walls are slidingly connected, and the adjustment plug and the through-groove wall are sealed, and the adjustment plug is connected for A driving assembly that drives the adjusting plug to slide.

By adopting the above technical solution, the driving assembly drives the adjustment plug to move, and by adjusting the distance between the adjustment plug and the second sealing head, the volume of the pressure chamber can be adjusted, so that after the volume in the pressure chamber becomes smaller, the pressure chamber can be The pressure in the tank is increased, and the pressure chamber can be pressurized conveniently.

Optionally, the drive assembly includes a drive seat, a drive block and a linkage block. The linkage block is connected to one end of the adjustment plug extending out of the pressure chamber. A drive cavity is provided in the drive seat, and the drive cavity is A sliding groove is provided through the wall of a cavity, and the linkage block extends into the driving cavity through the sliding groove. The linkage block is slidingly connected to the wall of the sliding groove, and the linkage block The driving block is provided with a seal between the sliding groove wall and the sliding groove wall; the driving block is provided at one end of the linkage block extending into the driving cavity, and the driving block is slidingly connected to the driving cavity wall. The block divides the driving chamber into a first fluid chamber and a second fluid chamber that are independent of each other. The driving seat is connected with a device for injecting fluid into the first fluid chamber, extracting fluid from the second fluid chamber, or for extracting fluid from the second fluid chamber. A circulation component for injecting fluid into the second fluid chamber and extracting fluid from the first fluid chamber.

By adopting the above technical solution, under the action of the circulation component, the fluid flows in the first fluid chamber and the second fluid chamber, so that the pressure difference between the first fluid chamber and the second fluid chamber can be used to make the driving block follow the prescribed requirements. Directional sliding, when the driving block moves toward the pressure chamber, it can drive the adjusting plug to move toward the second sealing head, thereby conveniently pressurizing the pressure chamber.

Optionally, the circulation component includes a first circulation pipe, a second circulation pipe, a third circulation pipe and a fourth circulation pipe, one end of the first circulation pipe and the second circulation pipe are both connected to the drive seat, the first circulation pipe is in communication with the first fluid cavity, the second circulation pipe is in communication with the first fluid cavity, an end of the first circulation pipe away from the drive seat and an end of the second circulation pipe away from the drive seat are connected through a circulation pump; one end of the third circulation pipe is in communication with a position of the first circulation pipe close to the drive seat, and the other end of the third circulation pipe is in communication with a position of the second circulation pipe close to the circulation pump; one end of the fourth circulation pipe is in communication with a position of the second circulation pipe close to the drive seat, and the other end of the fourth circulation pipe is in communication with a position of the first circulation pipe close to the circulation pump; a second control valve is provided at a position of the first circulation pipe between the third circulation pipe and the fourth circulation pipe, a position of the third circulation pipe close to the second circulation pipe, a position of the second circulation pipe between the third circulation pipe and the fourth circulation pipe, and a position of the fourth circulation pipe close to the second circulation pipe.

By adopting the above technical solution, closing the first valve and the second valve, opening the third valve and the fourth valve, the fourth circulation pipe, the fluid pump, and the third circulation pipe form a fluid flow between the first fluid chamber and the second fluid chamber. aisle. Close the third valve and the fourth valve, open the first valve and the second valve, and a fluid flow channel is formed between the first circulation pipe, the circulation pump, and the second circulation pipe; after starting the circulation pump, the fluid can flow according to the regulations channel, which can realize fluid flow in the first fluid chamber and the second fluid chamber move.

Optionally, the filling pipe is connected to a discharge pipe at a position between the first control valve and the pressure chamber, and a third control valve is provided on the discharge pipe.

To sum up, this application includes at least one of the following beneficial technical effects:

1. In this application, after sealing the pressure chamber, the fluid medium is continuously injected into the pressure chamber to conveniently pressurize the pressure chamber and realize water purification pressure treatment of medical materials or raw materials for preparing medical materials.

2. In this application, after sealing the pressure chamber, the pressure chamber can be easily pressurized by moving the adjusting plug to reduce the volume of the pressure chamber.

3. This application is equipped with a temperature adjustment component. When the temperature in the pressure chamber is too high or too low, the temperature of the fluid medium in the pressure chamber can be adjusted in time, which improves the effect of pressurizing medical materials or raw materials for preparing medical materials. .

4. The fluid storage tank of this application is equipped with a second temperature detector, which can detect the temperature of the fluid medium in the fluid storage tank in real time. It can not only work with the temperature adjustment component; but also can directly control the temperature of the fluid in the fluid storage tank. The temperature of the fluid medium in the fluid storage tank is used to offset the temperature change difference of the pressure chamber during the pressurization process.

Description of the drawings

Figure 1 is a schematic structural diagram of high-pressure equipment for medical material processing in Embodiment 1 of the present application.

FIG. 2 is a cross-sectional view along line A-A in FIG. 1 .

Figure 3 is a schematic structural diagram of high-pressure equipment for medical material processing in Embodiment 2 of the present application.

Figure 4 is a schematic structural diagram of high-pressure equipment for medical material processing in Embodiment 3 of the present application.

FIG. 5 is a cross-sectional view along line B-B in FIG. 4 .

Figure 6 is a schematic structural diagram of high-pressure equipment for medical material processing in Embodiment 4 of the present application.

FIG. 7 is a cross-sectional view along line C-C in FIG. 6 .

Figure 8 is a schematic structural diagram of high-pressure equipment for medical material processing in Embodiment 5 of the present application.

FIG. 9 is a cross-sectional view along line D-D in FIG. 8 .

Explanation of reference signs: 1. Pressure chamber; 11. Pass-through slot; 12. Feed-through slot; 13. Adjustment slot; 2. Base; 3. Sealing component; 31. First sealing head; 311. Neutralizing tube; 312 , the fourth control valve; 313, the third temperature detector; 32, the first driving member; 33, the first sealing plate; 34, the first sealing plug; 35, the first sealing piece; 36, the second sealing head; 361 , second sealing plate; 362, second sealing plug; 37, adjustment plug; 38, second driving member; 39, second sealing gasket; 4, fluid filling assembly; 41, fluid storage tank; 42, filling pipe ; 43. Fluid pump; 44. Water pumping pipe; 45. First control valve; 46. Discharge pipe; 47. Third control valve; 48. Pressure detector; 5. Pressure balance piece; 51. Balance pipe; 52. Pressure balance valve; 6. Temperature adjustment component; 61. Adjustment fluid tank; 62. Second temperature detector; 63. Connecting pipe; 64. Power pump; 65. First temperature detector; 7. Driving assembly; 71. Driving seat; 72. Driving block; 73. Linkage block; 74. Driving chamber; 75. Sliding groove; 76. First fluid chamber; 77. Second flow Body cavity; 78, pressure detector; 79, regulating pipe; 791, pressure regulating valve; 8, circulation component; 81, first circulation pipe; 82, second circulation pipe; 83, third circulation pipe; 84, fourth circulation Pipe; 85, circulation pump; 86, second control valve; 861, first valve; 862, second valve; 863, third valve; 864, fourth valve.

Detailed ways

The present application will be further described in detail below in conjunction with the accompanying drawings.

As a biomedical material, acellular tissue has been widely used in the field of tissue transplantation due to its low rejection reaction. Decellularization technology is a technology for obtaining decellularized tissues. The process is to remove cells from allogeneic or xenogeneic tissues through chemical and physical methods, thereby forming a biological tissue scaffold with no or low immunogenicity.

In this embodiment, as an example to obtain decellularized tissue biomedical materials, the high-pressure equipment for medical material processing of the present application is used to perform hydrostatic pressure treatment on the biological tissue, remove cells in the biological tissue, and sterilize the biological tissue to obtain Decellularized tissue, in which the fluid medium can be physiological saline, etc.

Example 1

Embodiment 1 provides a high-pressure device for processing medical materials.

As shown in Figures 1 and 2, a high-pressure equipment for medical material processing includes a pressure chamber 1 and a base 2. The pressure chamber 1 in this embodiment is cylindrical. On the side wall of one axial end of the pressure chamber 1 There is a through groove 11 running through, and the other axial end of the pressure chamber 1 is closed. The pressure chamber 1 is fixedly connected to the base 2; the base 2 is equipped with a sealing component 3, and the pressure chamber 1 is connected to a fluid filling component 4. Operate the sealing component 3 to open the channel 11, put the biological tissue into the pressure chamber 1, operate the sealing component 3 to close the channel 11; then operate the fluid filling component 4 to fill the pressure chamber 1 with fluid medium, in this embodiment The fluid medium is physiological saline; when pressurization is required, continue to operate the fluid filling component 4 to inject the fluid medium into the pressure chamber 1. During this process, the volume in the pressure chamber 1 remains unchanged, and the pressurization operation can be realized.

As shown in Figures 1 and 2, the sealing assembly 3 includes a first sealing head 31, and a first driving member 32 is fixedly connected to the base 2. The first driving member 32 in this embodiment can drive a cylinder, a hydraulic cylinder, etc., The first driving component 7 in this embodiment is a driving cylinder; the driving end of the first driving member 32 is opposite to the through groove 11 along the axial direction of the pressure chamber 1; the first sealing head 31 includes a third driving end fixedly connected to the first driving member 32. A sealing plate 33 and a first sealing plug 34 fixedly connected to the side wall of the first sealing plate 33 facing away from the first driving member 32. The first sealing plug 34 is inserted into the through groove 11 and pressed against the wall of the through groove 11. A first sealing piece 35 is fixedly connected to the side wall of the first sealing plate 33 facing the pressure chamber 1, and the first sealing piece 35 is in tight contact with the end wall of the pressure chamber 1. Activate the first driving member 32 to make the first sealing plate 33 and the first sealing plug 34 move away from the pressure chamber 1 to open the through slot 11; activate the first driving member 32 and insert the first sealing plug 34 into the through channel 11. so that the first sealing plate 33 and the pressure The end wall of the force chamber 1 is pressed tightly, and the pressure chamber 1 can be closed.

As shown in Figures 1 and 2, the fluid filling assembly 4 in this embodiment includes a fluid storage tank 41 and a filling pipe 42. One end of the filling pipe 42 is fixedly connected to the first sealing head 31, and the filling pipe 42 passes through After passing through the first sealing plate 33 and the first sealing plug 34, it extends into the pressure chamber 1. The first sealing plate 33 and the first sealing plug 34 are both sealingly connected to the outer wall of the filling pipe 42, and the other end of the filling pipe 42 is connected. There is a fluid pump 43. One end of the fluid pump 43 away from the filling pipe 42 is connected to a water pumping pipe 44. One end of the water pumping pipe 44 away from the fluid pump 43 extends into the fluid storage tank 41. A first control valve 45 is installed on the filling pipe 42 between the fluid pump 43 and the first sealing plate 33 . The filling pipe 42 is connected to a discharge pipe 46 at a position between the first control valve 45 and the first sealing plate 33 , and a third control valve 47 is installed on the discharge pipe 46 . At the same time, in this embodiment, a pressure balance member 5 is also installed on the first sealing head 31. The pressure balance member 5 includes a balance tube 51 fixedly connected to the first sealing head 31. The balance tube 51 passes through the first sealing plate 33. and the first sealing plug 34 extends into the pressure chamber 1. The first sealing plate 33 and the first sealing plug 34 are both sealingly connected to the outer wall of the balance pipe 51. The balance pipe 51 extends out of the first sealing head 31 and is installed on the pipe wall. There is a pressure balancing valve 52. In addition, in this embodiment, a pressure detector 48 is installed on the first sealing plug 34 .

The working principle of a high-pressure equipment for medical material processing in Embodiment 1 is as follows: put biological tissue into the pressure chamber 1, start the first driving part 32, so that the first sealing head 31 is inserted into the through groove 11, and the first sealing The head 31 and the first sealing plate 33 close the channel 11 of the pressure chamber 1 . Open the pressure balance valve 52, start the fluid pump 43, fill the pressure chamber 1 with the fluid medium in the fluid storage tank 41, and then close the pressure balance valve 52. According to the needs of the working conditions, continue to add pressure to the pressure chamber 1. Since the volume in the pressure chamber 1 remains unchanged, the pressure in the pressure chamber 1 increases until the pressure detector 48 detects that the pressure in the pressure chamber 1 reaches the requirement. Perform decellularization of biological tissues. After the high-pressure treatment is completed, the pressure is released, and then the third control valve 47 is opened to discharge the fluid medium in the pressure chamber 1 . Finally, the first driving member 32 is started, the first sealing head 31 is moved away from the pressure chamber 1, and the processed biological tissue is taken out.

Example 2

As shown in FIG. 3 , a high-pressure equipment for medical material processing, the difference between Embodiment 2 and Embodiment 1 is that a second temperature detector 62 is fixedly installed in the fluid storage tank 41 . Before the formal high-pressure treatment, a simulated pressurization operation is performed according to the prescribed pressurization conditions to obtain the temperature change value of the fluid medium in the pressure chamber 1 during the entire pressurization process. Based on this change value, the required temperature of the fluid storage tank 41 is deduced. Fluid medium temperature range. When the pressurization operation is officially carried out, the second temperature detector 62 detects the temperature of the fluid medium in the fluid storage tank 41 in real time. If the temperature of the fluid medium in the fluid storage tank 41 is abnormal, the second temperature detector 62 directly detects the temperature of the fluid medium in the fluid storage tank 41. Just adjust the temperature. The temperature of the fluid medium in the fluid storage tank 41 can be adjusted by adding a fluid medium of appropriate temperature for neutralization, or by using equipment such as a cooler or a heating pipe for adjustment.

Example 3

As shown in FIG4 and FIG5, a high-pressure device for processing medical materials, the difference between Example 3 and Example 2 is that: a temperature regulating assembly 6 is installed on the pressure chamber 1 of this embodiment. The temperature regulating assembly 6 includes a regulating fluid box 61, in which cold fluid or hot fluid is stored. The regulating fluid box 61 of this embodiment stores cold fluid, and the cold fluid and the fluid medium in the fluid storage box 41 are the same substance. The regulating fluid box 61 is connected to a connecting pipe 63, which is connected to the fluid storage box 41 through a power pump 64, and a first temperature detector 65 is fixedly installed on the side wall of the first sealing plug 34 extending into the pressure chamber 1.

The working principle of a high-pressure equipment for medical material processing in Embodiment 3 is as follows: the first temperature detector 65 detects the temperature of the fluid medium in the pressure chamber 1. Once the temperature in the pressure chamber 1 is found to be too high, the automatic control system will The power pump 64 is turned on, and the cold fluid in the regulating fluid tank 61 is injected into the fluid storage tank 41 for neutralization. At the same time, the second temperature detector 62 detects the temperature of the fluid storage tank 41 in real time. After the temperature of the fluid medium in the fluid storage tank 41 is appropriate, the automatic control system starts the fluid pump 43 and adds lower-temperature fluid medium into the pressure chamber 1 until the temperature in the pressure chamber 1 reaches a suitable range. Alternatively, a lower-temperature fluid medium may be added to the pressure chamber 1, and at the same time, while ensuring the operating safety of the pressure chamber 1, the third control valve 47 may be opened, and the higher-temperature fluid medium may be discharged from the pressure chamber 1, and then The temperature of the fluid medium in the pressure chamber 1 can be adjusted faster.

Example 4

As shown in Figures 6 and 7, a high-pressure equipment for medical material processing. The difference between Embodiment 4 and Embodiment 1 is that the pressure chamber 1 of this embodiment is equipped with a temperature adjustment assembly 6. The temperature adjustment assembly 6 It includes a neutralization tube 311. The neutralization tube 311 is installed on the first sealing head 31. The neutralization tube 311 passes through the first sealing plate 33 and the first sealing plug 34 and then extends into the pressure chamber 1. The first sealing plate 33 and The first sealing plugs 34 are all sealingly connected to the outer wall of the neutralizing tube 311. A fourth control valve 312 is installed on the closing portion of the neutralizing tube 311 extending out of the pressure chamber 1. Moreover, in this embodiment, a third temperature detector 313 is installed on the side of the first sealing plug 34 away from the first sealing plate 33 . The third temperature detector 313 detects the temperature in the pressure chamber 1 in real time. If the temperature in the pressure chamber 1 is too high or too low, the fourth control valve 312 is opened and fluid medium is injected into the pressure chamber 1 through the neutralization pipe 311. and the temperature in the pressure chamber 1 until the temperature in the pressure chamber 1 is suitable, and then continue to pressurize the pressure chamber 1 normally.

Example 5

As shown in Figures 8 and 9, a high-pressure equipment for medical material processing, the difference between Embodiment 5 and Embodiment 3 is that the pressure chamber 1 in this embodiment has a through hole at both axial end side walls. For the convenience of description, one of the slots 11 is named the feed slot 12, and the other slot 11 is named the adjustment slot 13. The sealing assembly 3 includes a second sealing head 36 and an adjusting plug 37; the base 2 is installed with a second driving member 38 at a position relative to the feed chute 12. The second driving member 38 may be a driving cylinder, a hydraulic cylinder, etc., in this embodiment The second driving member 38 in this example is a driving cylinder. In this embodiment, the second sealing head 36 packs It includes a second sealing plate 361 fixedly connected to the driving end of the second driving member 38 and a second sealing plug 362 fixedly connected to the side wall of the second sealing plate 361 facing the pressure chamber 1. The second sealing plug 362 is inserted into the through material. In the groove 12 and against the wall of the feed groove 12. A second sealing gasket 39 is fixedly connected to the side of the second sealing plate 361 facing the pressure chamber 1, and the second sealing plate 361 is in tight contact with the end wall of the pressure chamber 1. At the same time, the balance pipe 51 and the filling pipe 42 are both installed on the second sealing head 36 , and the first temperature detector 65 and the pressure detector 48 are installed on the side wall of the second sealing plug 362 away from the second sealing plate 361 superior.

As shown in Figures 8 and 9, the adjusting plug 37 extends into the pressure chamber 1 through the adjusting groove 13, the adjusting plug 37 is connected to the groove wall of the adjusting groove 13 by sliding, and a seal is set between the adjusting plug 37 and the groove wall of the through groove 11. A driving component 7 for driving the adjusting plug 37 to slide is installed on the base 2.

As shown in Figures 8 and 9, the driving assembly 7 in this embodiment includes a driving base 71, a driving block 72 and a linkage block 73. The driving base 71 is fixedly connected to the base 2 and faces the adjustment groove 13. The driving base 71 A driving cavity 74 is provided inside, and a sliding groove 75 is provided through the cavity wall of the driving cavity 74 close to and opposite to the feed chute 12 . The linkage block 73 is fixedly connected to one end of the adjustment plug 37 extending out of the pressure chamber 1. The linkage block 73 extends into the drive cavity 74 through the sliding groove 75. At the same time, the linkage block 73 is slidingly connected to the sliding groove 75 walls, and the linkage block 73 is slidably connected to the sliding groove 75. 73 and the sliding groove 75 are sealed between the groove walls. The driving block 72 is fixedly connected to one end of the linkage block 73 extending into the driving cavity 74. The peripheral wall of the driving block 72 and the cavity wall of the driving cavity 74 are slidingly connected and sealed. The driving block 72 divides the driving cavity 74 into mutually independent first fluid chambers. 76 and the second fluid chamber 77 , the first fluid chamber 76 is located on the side of the second fluid chamber 77 away from the pressure chamber 1 . At the same time, pressure detectors 78 are fixedly installed on the walls of the first fluid chamber 76 and the second fluid chamber 77, and the chamber walls of the first fluid chamber 76 and the second fluid chamber 77 are connected with a regulating tube 79, and the regulating tube 79 extends A pressure regulating valve 791 is installed on the pipe wall coming out of the driving seat 71 .

As shown in Figures 8 and 9, a circulation component 8 is installed on the drive seat 71, and the circulation component 8 includes a first circulation pipe 81, a second circulation pipe 82, a third circulation pipe 83 and a fourth circulation pipe 84. One end of the first circulation pipe 81 and the second circulation pipe 82 are connected to the drive seat 71, and the first circulation pipe 81 is communicated with the first fluid cavity 76, and the second circulation pipe 82 is communicated with the first fluid cavity 76. The end of the first circulation pipe 81 away from the drive seat 71 is connected to a circulation pump 85, and the circulation pump 85 is connected to one end of the first circulation pipe 81 away from the drive seat 71 and the end of the second circulation pipe 82 away from the drive seat 71.

As shown in FIGS. 8 and 9 , one end of the third circulation pipe 83 is connected to the position of the first circulation pipe 81 close to the driving seat 71 , and one end of the third circulation pipe 83 is far away from the first circulation pipe 81 and the second circulation pipe 82 The positions close to the circulation pump 85 are connected. One end of the fourth circulation pipe 84 is connected with the position of the second circulation pipe 82 close to the driving seat 71 , and one end of the fourth circulation pipe 84 away from the second circulation pipe 82 is connected with the position of the first circulation pipe 81 close to the circulation pump 85 . The first circulation pipe 81 is located between the third circulation pipe 83 and the fourth circulation pipe 84 , the third circulation pipe 83 is close to the second circulation pipe 82 , and the second circulation pipe 82 is between the third circulation pipe 83 and the fourth circulation pipe 82 . A second control valve 86 is installed between the circulation pipes 84 and at a position where the fourth circulation pipe 84 is close to the second circulation pipe 82 . For convenience of description, the second control valve 86 on the first circulation pipe 81 is The first valve 861 is named, the second control valve 86 on the second circulation pipe 82 is named the second valve 862, the second control valve 86 on the third circulation pipe 83 is named the third valve 863, and the fourth circulation pipe 84 The second control valve 86 is named fourth valve 864.

In the high-pressure equipment for medical material processing in Embodiment 5 of the present application, there are two pressurization methods, one of which is to maintain the position of the adjusting plug 37 unchanged and continue to add fluid medium into the pressure chamber 1 to perform pressurization.

Another pressurizing device is: do not continue to add fluid medium into the pressure chamber 1; close the first valve 861 and the second valve 862, open the third valve 863 and the fourth valve 864, open the circulation pump 85, so that the second The liquid in the fluid chamber 77 enters the first fluid chamber 76 through the fourth circulation pipe 84, the fluid pump 43, and the third circulation pipe 83, causing the driving block 72 to move toward the pressure chamber 1, and then the linkage block 73 drives the adjustment plug 37 toward the third The two sealing plugs 362 move, causing the volume in the pressure chamber 1 to become smaller, thereby achieving pressurization. When pressure relief is required, close the third valve 863 and the fourth valve 864, start the circulation pump 85, open the first valve 861 and the second valve 862, so that the liquid in the first fluid chamber 76 passes through the first circulation pipe 81 and the circulation pump. 85. The second circulation pipe 82 enters the second fluid chamber 77 so that the driving block 72 drives the adjusting plug 37 away from the second sealing plug 362 .

At the same time, in order to improve safety during the pressurization process, the pressure detector 78 detects the pressure in the first fluid chamber 76 and the second fluid chamber 77 in real time. If the pressure is abnormal, the pressure can be adjusted through the pressure regulating valve 791.

The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application shall be covered by the scope of protection of the present application. Inside.

Claims

A high-pressure equipment for medical material processing, characterized by: including a pressure chamber (1) for placing medical materials and/or raw materials for preparing medical materials, and at least one hole is penetrated through the side wall of the pressure chamber (1). Through slot (11), the high-pressure equipment also includes a sealing assembly (3) for closing the through slot (11), and the pressure chamber (1) is connected to a fluid filling assembly (4).
A high-pressure equipment for medical material processing according to claim 1, characterized in that: the fluid filling assembly (4) includes a fluid storage tank (41) and a filling pipe (42), and the filling pipe (42) 42) One end is connected to the pressure chamber (1), and the other end of the filling pipe (42) is connected to the fluid storage tank (41) through a fluid pump (43). The filling pipe (42) A first control valve (45) is provided between the fluid pump (43) and the pressure chamber (1), and a pressure balance member (5) is also provided on the pressure chamber (1).
The high-pressure equipment for medical material processing according to claim 2, characterized in that: a second temperature detector (62) is provided in the fluid storage tank (41).
A high-pressure equipment for medical material processing according to claim 1, characterized in that: the pressure chamber (1) is provided with a temperature adjustment component (6).
A high-pressure equipment for medical material processing according to claim 4, characterized in that: the temperature regulating assembly (6) includes a regulating fluid tank (61) for storing cold fluid or hot fluid, and the regulating fluid tank (61) is connected to a connecting pipe (63), which is connected to the fluid filling assembly (4) through a power pump (64), and a first temperature detection device is provided in the pressure chamber (1). Device(65).
A high-pressure equipment for medical material processing according to claim 4, characterized in that: the temperature adjustment assembly (6) includes a neutralization tube (311), the neutralization tube (311) and the pressure chamber ( 1) Connected, the neutralization tube (311) extends out of the pressure chamber (1) and is provided with a fourth control valve (312) on the wall of the pressure chamber (1), and a third temperature detector is provided in the pressure chamber (1) (313).
A high-pressure equipment for medical material processing according to claim 1, characterized in that: the sealing assembly (3) includes a first sealing head (31), and the first sealing head (31) is inserted into the through groove. (11) and is in contact with the groove wall of the through groove (11). The first sealing head (31) is connected with a first driving member (32) for driving the movement of the first sealing head (31).
A high-pressure equipment for medical material processing according to claim 1, characterized in that: there are two through grooves (11), and the sealing assembly (3) includes a second sealing head (36) and an adjustment plug ( 37), the second sealing head (36) is inserted into one of the through grooves (11) and abuts against the wall of the through groove (11). The second sealing head (36) is connected to a The second driving member (38) of the second sealing head (36) slides; the regulating plug (37) extends into the pressure chamber (1) through the other through groove (11), and the regulating plug (37) is slidingly connected to the groove wall of the through groove (11), and the adjustment plug (37) and the groove wall of the through groove (11) are sealed, and the adjustment plug (37) is connected effectively A driving assembly (7) that drives the adjusting plug (37) to slide.
A high-voltage equipment for medical material processing according to claim 8, characterized in that: the driving assembly (7) includes a driving base (71), a driving block (72) and a linkage block (73), and the linkage block (73) is connected to the regulating plug (37) and extends out of the pressure chamber (1), a driving cavity (74) is provided in the driving seat (71), a sliding groove (75) is provided through a cavity wall of the driving cavity (74), and the linkage block (73) ) extends into the driving cavity (74) through the sliding groove (75), the linkage block (73) and the sliding groove (75) wall are slidingly connected, and the linkage block (73 ) and the groove wall of the sliding groove (75) are sealed; the driving block (72) is provided at one end of the linkage block (73) extending into the driving cavity (74), and the driving block (72) 72) is slidingly connected to the wall of the driving chamber (74), and the driving block (72) divides the driving chamber (74) into a first fluid chamber (76) and a second fluid chamber (77) that are independent of each other. , the driving seat (71) is connected with a device for injecting fluid into the first fluid chamber (76), extracting fluid from the second fluid chamber (77), or for injecting fluid into the second fluid chamber (77). A circulation assembly (8) for injecting fluid into the first fluid chamber (76) and extracting fluid from the first fluid chamber (76).
A high-pressure equipment for medical material processing according to claim 9, characterized in that the circulation component (8) includes a first circulation pipe (81), a second circulation pipe (82), and a third circulation pipe (83). ) and a fourth circulation pipe (84). One end of the first circulation pipe (81) and the second circulation pipe (82) is connected to the driving seat (71). The first circulation pipe (81) ) communicates with the first fluid chamber (76), the second circulation tube (82) communicates with the first fluid chamber (76), and the first circulation tube (81) is away from the driving seat (71) One end of the second circulation pipe (82) and the end away from the driving seat (71) are connected through a circulation pump (85); one end of the third circulation pipe (83) is connected to the first circulation pipe (81) The position close to the driving seat (71) is connected, and the other end of the third circulation pipe (83) is connected to the position of the second circulation pipe (82) close to the circulation pump (85); One end of the fourth circulation pipe (84) is connected to the position of the second circulation pipe (82) close to the driving seat (71), and the other end of the fourth circulation pipe (84) is connected to the first circulation pipe (82). The pipes (81) are connected near the circulation pump (85); the first circulation pipe (81) is located between the third circulation pipe (83) and the fourth circulation pipe (84). , the third circulation pipe (83) is close to the second circulation pipe (82), and the second circulation pipe (82) is located between the third circulation pipe (83) and the fourth circulation pipe (84) A second control valve (86) is provided at the position between the fourth circulation pipe (84) and the position near the second circulation pipe (82).