WO2024053363A1 - Liquid purification device and liquid purification method - Google Patents

Liquid purification device and liquid purification method Download PDF

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WO2024053363A1
WO2024053363A1 PCT/JP2023/029857 JP2023029857W WO2024053363A1 WO 2024053363 A1 WO2024053363 A1 WO 2024053363A1 JP 2023029857 W JP2023029857 W JP 2023029857W WO 2024053363 A1 WO2024053363 A1 WO 2024053363A1
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liquid
target
passage
unpurified
target liquid
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Japanese (ja)
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一嘉 宮脇
謙一 小久保
弘之 青木
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フィジオロガス・テクノロジーズ株式会社
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes

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  • the present invention relates to an apparatus and method for purifying a target liquid.
  • the present invention aims to provide a target liquid purification device and a target liquid purification method that supply a replenisher to an appropriate location in a regeneration circuit. purpose.
  • the target liquid purification device of the present invention includes: A target liquid purification device for removing at least one target substance from an unpurified target liquid, comprising: comprising a porous membrane having a pore size through which the target substance contained in the unpurified target liquid can pass, and allowing the unpurified target liquid containing the target substance to pass through the porous membrane from the first part.
  • a separation device that generates a filtered dialysate by introducing the dialysis fluid into the second part, and generates a purified target liquid by removing the target substance contained in the unpurified target liquid through the passage; an unpurified target liquid passage for introducing the unpurified target liquid into the first part of the separation device; a purified target liquid passage for leading out the purified target liquid from the first portion of the separation device; a filtrate dialysate passageway for directing the filtrate dialysate from the second portion of the separation device; A drainage passage branching from the filtration dialysate passage and disposing of the first liquid as a waste liquid among the first liquid and the second liquid as a result of separating the filtration dialysate; , It has an adsorbent that adsorbs the target substance, and by bringing the second liquid introduced from the filtration dialysate passage into contact with the adsorbent, at least a portion of the target substance is removed from the second liquid.
  • a regeneration circuit that removes the target substance and generates a regeneration liquid in which the concentration of the target substance is reduced; a regeneration liquid passageway for introducing the regeneration liquid from the regeneration circuit into the second portion of the separation device; A first replenisher passageway that directly introduces a replenisher liquid into at least one of the unpurified target liquid passageway and the purified target liquid passageway.
  • a second replenisher passageway for directly introducing the replenisher liquid into the regeneration liquid passageway is provided.
  • a regenerating liquid branch passage is provided for introducing the regenerating liquid from the regenerating liquid passage into at least one of the unpurified target liquid passage and the purified target liquid passage.
  • FIG. 1 is a configuration explanatory diagram of a target liquid purification device as a first embodiment of the present invention.
  • FIG. FIG. 2 is a configuration explanatory diagram of a target liquid purification device as a second embodiment of the present invention.
  • FIG. 7 is a configuration explanatory diagram of a target liquid purification device as a third embodiment of the present invention.
  • FIG. 4 is a configuration explanatory diagram of a target liquid purification device as a fourth embodiment of the present invention.
  • FIG. 7 is an explanatory diagram of the configuration of a target liquid purification device as a fifth embodiment of the present invention.
  • FIG. 7 is an explanatory diagram of the configuration of a target liquid purification device as a sixth embodiment of the present invention.
  • the target liquid purification device as the first embodiment of the present invention shown in FIG. It includes a liquid passage 21, a regeneration liquid passage 22, a drainage passage 24, and a first replenishment liquid passage 412.
  • the separation device 100 is separated into a first portion 110 and a second portion 120 by a porous membrane 102.
  • the porous membrane 102 has a pore size that allows the target substance contained in the unpurified target liquid F11 (for example, blood, plasma, dialysis effluent, blood filtrate) to pass through.
  • target substances are, for example, at least one of potassium ions, ammonium ions, calcium ions, magnesium ions, phosphate ions, bicarbonate ions, and organic acid ions, urea, creatinine, uric acid, peptides, proteins, and other diseases. It is a pathogenic substance that accumulates in the body when the disease occurs.
  • the separation device 100 generates a filtered dialysate fluid F21 by passing an unpurified target liquid F11 containing a target substance from the first part 110 through the porous membrane 102 and introducing it into a second part 120. It is configured to generate a purified target liquid F12 by removing target substances contained in F11 through the passage.
  • the unpurified target liquid passage 11 is configured to introduce the unpurified target liquid F11 drawn out from the patient's body into the first portion 110 of the separation device 100.
  • the purified target liquid passage 12 is configured to lead the purified target liquid F12 out of the first portion 110 of the separation device 100 and introduce it into the patient's body.
  • Separation device 100 is composed of, for example, a dialyzer, first part 110 is an internal space of a hollow fiber composed of a dialysis membrane, and second part 120 is a dialysate and/or regenerated fluid around the hollow fiber. It is a space where things flow.
  • the separation apparatus 100 is a "counter-flow type" in which the flow direction of the unpurified target liquid F11 in the first part 110 and the flow direction of the regenerated liquid F22 in the second part 110 are opposite or opposite.
  • the separation device 100 is configured such that the flow direction of the unpurified target liquid F11 in the first portion 110 and the flow direction of the regenerated liquid F22 in the second portion 110 are parallel to each other. It may also be configured as a "co-current separator" in which the two components are separated or oriented in the same direction.
  • the regeneration circuit 200 includes an adsorbent that adsorbs the target substance.
  • adsorbent activated carbon, an adsorbent based on activated carbon, a porous adsorbent, a cation exchange resin, an anion exchange resin, an adsorbent made of zirconia ceramics, zeolite, etc., and mixtures thereof may be employed.
  • the regeneration circuit 200 removes at least a portion of the target substance by bringing a part of the filtration dialysate (second liquid F212) into contact with an adsorbent, and generates a regenerated liquid F22 in which the concentration of the target substance is reduced. It is configured as follows.
  • the filtered dialysate passage 21 is configured to lead out the filtered dialysate F21 from the second portion 120 of the separation device 100 and introduce a part thereof, the second liquid F212, into the regeneration circuit 200.
  • the drain passage 24 branches from the filtration dialysate passage 21, and among the first liquid F211 and second liquid F212 resulting from separation of the filtration dialysate F21, the first liquid F211 is used as a drain liquid. Configured to be discarded.
  • the flow rate of the drain fluid in the drain passage 24 (the amount of filtered dialysate F21 discarded) is determined by the amount of inflow of the replenisher (fresh dialysate) into the regeneration fluid passage 22 and/or the amount of outflow of the regeneration fluid F22 from the regeneration fluid passage. Based on this, the flow rate of the regenerating liquid F22 in the second portion 120 of the separation device 100 may be appropriately controlled.
  • the regeneration liquid passage 22 is configured to introduce the regeneration liquid F22 from the regeneration circuit 200 into the second portion 120 of the separation device 100.
  • the first replenisher passage 412 is configured to directly introduce the first replenisher F41 into the purified target liquid passage 12.
  • "Replenishment fluid” means, for example, fresh dialysate or filtration replenishment fluid.
  • the target liquid purification method is carried out in the following steps. Each procedure or step may be performed in parallel.
  • the unpurified target liquid F11 is introduced into the first portion 110 of the separation device 100 (S1).
  • the unpurified target liquid F11 containing the target substance is introduced into the second part 120 from the first part 110 through the porous membrane 102 in the separation device 100, thereby generating a filtered dialysate F21 (S2).
  • the target substance contained in the unpurified target liquid F11 is removed by passing through the porous membrane 102, thereby generating a purified target liquid F12 (S3).
  • the purified target liquid F12 is led out from the first portion 110 of the separation device 100 (S4).
  • the filtered dialysate F21 is led out from the second portion 120 of the separation device 100 (S5).
  • the first liquid F211 is discarded as waste liquid (S6).
  • the second liquid F212 comes into contact with the adsorbent in the regeneration circuit 200, at least a portion of the target substance is removed from the second liquid F212, and a regenerated liquid F22 with a reduced concentration of the target substance is generated (S7 ).
  • Regeneration liquid F22 is introduced into second portion 120 of separation device 100 (S8). Then, the first replenisher fluid F41 is directly mixed with the purified target fluid F12 (S9).
  • a target liquid purification device as a second embodiment of the present invention shown in FIG. 2 has a configuration in which a second replenisher passage 422 is added to the target liquid purification device of the first embodiment (see FIG. 1). are doing.
  • the second replenisher passage 422 is configured to directly introduce the second replenisher F42 into the regeneration liquid passage 22.
  • the supply sources of the second replenisher F42 and the first replenisher F41 may be a common supply source or may be separate supply sources.
  • the other configurations of the target liquid purification device of the second embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
  • a target liquid purification device as a third embodiment of the present invention shown in FIG. 3 has a configuration in which a regeneration liquid branch passage 221 is added to the target liquid purification device of the first embodiment (see FIG. 1). ing.
  • the regeneration liquid branch passage 221 is configured to directly introduce a portion of the regeneration liquid F22 into the unpurified target liquid passage 11.
  • the other configurations of the target liquid purification device of the third embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations will be given the same reference numerals and explanations will be omitted.
  • the target liquid purification device according to the fourth embodiment of the present invention shown in FIG. A liquid passage 411 is provided.
  • the first replenisher passage 411 is configured to directly introduce the first replenisher F41 into the unpurified target liquid passage 11 instead of the purified target liquid passage 12.
  • the other configurations of the target liquid purification device of the fourth embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
  • the target liquid purification method is carried out in the following steps. Each procedure or step may be performed in parallel.
  • the unpurified target liquid F11 is introduced into the first portion 110 of the separation device 100 (S1).
  • the unpurified target liquid F11 containing the target substance is introduced into the second part 120 from the first part 110 through the porous membrane 102 in the separation device 100, thereby generating a filtered dialysate F21 (S2).
  • the target substance contained in the unpurified target liquid F11 is removed by passing through the porous membrane 102, thereby generating a purified target liquid F12 (S3).
  • the purified target liquid F12 is led out from the first portion 110 of the separation device 100 (S4).
  • the filtered dialysate F21 is led out from the second portion 120 of the separation device 100 (S5).
  • the first liquid F211 is discarded as waste liquid (S6).
  • the second liquid F212 comes into contact with the adsorbent in the regeneration circuit 200, at least a portion of the target substance is removed from the second liquid F212, and a regenerated liquid F22 with a reduced concentration of the target substance is generated (S7 ).
  • Regeneration liquid F22 is introduced into second portion 120 of separation device 100 (S8). Then, the first replenisher fluid F41 is directly mixed with the unpurified target fluid F11 (S9').
  • the target liquid purifying device as the fifth embodiment of the present invention shown in FIG. 5 has a configuration in which a second replenisher passage 422 is added to the target liquid purifying device of the fourth embodiment (see FIG. 4). are doing.
  • the second replenisher passage 422 is configured to directly introduce the second replenisher F42 into the regeneration liquid passage 22.
  • the supply sources of the second replenisher F42 and the first replenisher F41 may be a common supply source or may be separate supply sources.
  • the other configurations of the target liquid purification device of the fifth embodiment are almost the same as the configuration of the target liquid purification device of the fourth embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
  • the target liquid purification device as the sixth embodiment of the present invention shown in FIG. 6 has a configuration in which a regeneration liquid branch passage 222 is added to the target liquid purification device of the fourth embodiment (see FIG. 4). ing.
  • the regeneration liquid branch passage 222 is configured to directly introduce a portion of the regeneration liquid F22 into the purified target liquid passage 12.
  • the other configurations of the target liquid purification device of the sixth embodiment are almost the same as the configuration of the target liquid purification device of the fourth embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
  • the replenisher is supplied to an appropriate location in the regeneration circuit.
  • the device can be made smaller, making it suitable for use in home environments.
  • the target liquid purifying devices of the first to third embodiments of the present invention are the same as the target liquid purifying devices of the fourth to sixth embodiments of the present invention (see FIGS. 4 to 6).
  • One replenisher passage 411 may be added.
  • the first replenisher is directly supplied or introduced from each of the pair of first replenisher passages 411 and 412 to each of the unpurified target liquid passage 11 and the purified target liquid passage 12.
  • Each of the pair of first replenisher passages 411 and 412 may communicate with a common replenisher supply source or may communicate with a separate replenisher supply source.
  • the regenerating liquid branch passage 222 of the sixth embodiment of the present invention may be added to the target liquid purification device of the first to fifth embodiments of the present invention (see FIGS. 1 to 5).
  • the regeneration liquid branch passage 221 of the third embodiment of the present invention is added to the target liquid purification device of the second and fourth to sixth embodiments of the present invention (see FIGS. 2 and 4 to 6). May be added.
  • Unpurified target liquid passage 12.
  • Purified target liquid passage 21. Filtered dialysate passage 22.

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Abstract

In order to decrease the total amount of dialysate used in dialysis methods, a liquid purification device and a liquid purification method that supply supplementary liquid at an appropriate position of a regeneration circuit are provided. An unpurified liquid passage (11) introduces unpurified liquid (F11) into a first part (110) of a separation device (100). A purified liquid passage (12) evacuates purified liquid (F12) from the first part (110) of the separation device (100). A diafiltrate passage (21) evacuates diafiltrate (F21) from a second part (120) of the separation device (100) and introduces a part thereof into a regeneration circuit (200). A regenerated liquid passage (22) introduces regenerated liquid (F22) from the regeneration circuit (200) into the second part (120) of the separation device (100). A first supplementary liquid passage (412) introduces first supplementary liquid (F41) directly into the purified liquid passage (12).

Description

対象液浄化装置および対象液浄化方法Target liquid purification device and target liquid purification method
　本発明は、対象液を浄化する装置および方法に関する。 The present invention relates to an apparatus and method for purifying a target liquid.
　従来、透析方法で使用される透析液の総量を減少させる観点から、吸着材を用いた部分再生を伴う血液浄化方法が提案されている（例えば、特許文献１参照）。 Conventionally, from the viewpoint of reducing the total amount of dialysate used in the dialysis method, a blood purification method that involves partial regeneration using an adsorbent has been proposed (for example, see Patent Document 1).
米国特許第９３０２０３８号明細書US Patent No. 9302038
　しかし、透析方法で使用される透析液の総量を減少させる観点から、補充液を再生回路に供給する方法には改善余地がある。 However, from the viewpoint of reducing the total amount of dialysate used in the dialysis method, there is room for improvement in the method of supplying the replenisher to the regeneration circuit.
　そこで、本発明は、透析方法で使用される透析液の総量を減少させる観点から、補充液を再生回路の適当な箇所に供給するような対象液浄化装置および対象液浄化方法を提供することを目的とする。 Therefore, from the viewpoint of reducing the total amount of dialysate used in the dialysis method, the present invention aims to provide a target liquid purification device and a target liquid purification method that supply a replenisher to an appropriate location in a regeneration circuit. purpose.
　本発明の対象液浄化装置は、
　未浄化対象液から少なくとも１つの対象物質を除去するための対象液浄化装置であって、
　前記未浄化対象液に含まれる前記対象物質が通過することができる孔径を有する多孔質膜を含み、前記対象物質を含む前記未浄化対象液を、前記第1部分から前記多孔質膜を通過させて前記第２部分に導入することで濾過透析液を生成し、前記未浄化対象液に含まれる前記対象物質を当該通過によって除去することで浄化済対象液を生成する分離装置と、
　前記未浄化対象液を前記分離装置の前記第１部分に導入するための未浄化対象液通路と、
　前記浄化済対象液を前記分離装置の前記第１部分から導出させるための浄化済対象液通路と、
　前記濾過透析液を前記分離装置の前記第２部分から導出させるための濾過透析液通路と、
　前記濾過透析液通路から分岐し、前記濾過透析液が分離された結果としての第１の液と第２の液とのうち、前記第１の液を排液として廃棄するための排液通路と、
　前記対象物質を吸着する吸着材を有し、前記濾過透析液通路から導入された前記第２の液を前記吸着材と接触させることにより、前記対象物質の少なくとも一部を前記第２の液から除去し、前記対象物質の濃度が減少した再生液を生成する再生回路と、
　前記再生液を前記再生回路から前記分離装置の前記第２部分に導入するための再生液通路と、
　補充液を前記未浄化対象液通路および前記浄化済対象液通路のうち少なくとも一方に直接的に導入する第１補充液通路と、を備えている。 The target liquid purification device of the present invention includes:
A target liquid purification device for removing at least one target substance from an unpurified target liquid, comprising:
comprising a porous membrane having a pore size through which the target substance contained in the unpurified target liquid can pass, and allowing the unpurified target liquid containing the target substance to pass through the porous membrane from the first part. a separation device that generates a filtered dialysate by introducing the dialysis fluid into the second part, and generates a purified target liquid by removing the target substance contained in the unpurified target liquid through the passage;
an unpurified target liquid passage for introducing the unpurified target liquid into the first part of the separation device;
a purified target liquid passage for leading out the purified target liquid from the first portion of the separation device;
a filtrate dialysate passageway for directing the filtrate dialysate from the second portion of the separation device;
A drainage passage branching from the filtration dialysate passage and disposing of the first liquid as a waste liquid among the first liquid and the second liquid as a result of separating the filtration dialysate; ,
It has an adsorbent that adsorbs the target substance, and by bringing the second liquid introduced from the filtration dialysate passage into contact with the adsorbent, at least a portion of the target substance is removed from the second liquid. a regeneration circuit that removes the target substance and generates a regeneration liquid in which the concentration of the target substance is reduced;
a regeneration liquid passageway for introducing the regeneration liquid from the regeneration circuit into the second portion of the separation device;
A first replenisher passageway that directly introduces a replenisher liquid into at least one of the unpurified target liquid passageway and the purified target liquid passageway.
　前記構成の対象液浄化装置において、
　前記補充液を前記再生液通路に直接的に導入する第２補充液通路を備えている
ことが好ましい。 In the target liquid purification device configured as described above,
It is preferable that a second replenisher passageway for directly introducing the replenisher liquid into the regeneration liquid passageway is provided.
　前記構成の対象液浄化装置において、
　前記再生液通路から前記未浄化対象液通路および前記浄化済対象液通路のうち少なくとも一方に前記再生液を導入する再生液分岐通路を備えている
ことが好ましい。 In the target liquid purification device configured as described above,
It is preferable that a regenerating liquid branch passage is provided for introducing the regenerating liquid from the regenerating liquid passage into at least one of the unpurified target liquid passage and the purified target liquid passage.
本発明の第１実施形態としての対象液浄化装置の構成説明図。1 is a configuration explanatory diagram of a target liquid purification device as a first embodiment of the present invention. FIG. 本発明の第２実施形態としての対象液浄化装置の構成説明図。FIG. 2 is a configuration explanatory diagram of a target liquid purification device as a second embodiment of the present invention. 本発明の第３実施形態としての対象液浄化装置の構成説明図。FIG. 7 is a configuration explanatory diagram of a target liquid purification device as a third embodiment of the present invention. 本発明の第４実施形態としての対象液浄化装置の構成説明図。FIG. 4 is a configuration explanatory diagram of a target liquid purification device as a fourth embodiment of the present invention. 本発明の第５実施形態としての対象液浄化装置の構成説明図。FIG. 7 is an explanatory diagram of the configuration of a target liquid purification device as a fifth embodiment of the present invention. 本発明の第６実施形態としての対象液浄化装置の構成説明図。FIG. 7 is an explanatory diagram of the configuration of a target liquid purification device as a sixth embodiment of the present invention.
　（第１実施形態）
　図１に示されている本発明の第１実施形態としての対象液浄化装置は、分離装置１００と、未浄化対象液通路１１と、浄化済対象液通路１２と、再生回路２００と、濾過透析液通路２１と、再生液通路２２と、排液通路２４と、第１補充液通路４１２と、を備えている。 (First embodiment)
The target liquid purification device as the first embodiment of the present invention shown in FIG. It includes a liquid passage 21, a regeneration liquid passage 22, a drainage passage 24, and a first replenishment liquid passage 412.
　分離装置１００は、多孔質膜１０２によって第１部分１１０と第２部分１２０とに分離されている。多孔質膜１０２は、未浄化対象液Ｆ１１（例えば、血液、血漿、透析排液、血液濾過液）に含まれる対象物質が通過することができる孔径を有する。「対象物質」は、例えば、カリウムイオン、アンモニウムイオン、カルシウムイオン、マグネシウムイオン、リン酸イオン、炭酸水素イオンおよび有機酸イオンのうち少なくとも１つのイオン、尿素、クレアチニン、尿酸、ペプチド、タンパク質などの病気になった時に体内に蓄積する病因物質である。分離装置１００は、対象物質を含む未浄化対象液Ｆ１１を、第1部分１１０から多孔質膜１０２を通過させて第２部分１２０に導入することで濾過透析液Ｆ２１を生成し、未浄化対象液Ｆ１１に含まれる対象物質を当該通過によって除去することで浄化済対象液Ｆ１２を生成するように構成されている。 The separation device 100 is separated into a first portion 110 and a second portion 120 by a porous membrane 102. The porous membrane 102 has a pore size that allows the target substance contained in the unpurified target liquid F11 (for example, blood, plasma, dialysis effluent, blood filtrate) to pass through. "Target substances" are, for example, at least one of potassium ions, ammonium ions, calcium ions, magnesium ions, phosphate ions, bicarbonate ions, and organic acid ions, urea, creatinine, uric acid, peptides, proteins, and other diseases. It is a pathogenic substance that accumulates in the body when the disease occurs. The separation device 100 generates a filtered dialysate fluid F21 by passing an unpurified target liquid F11 containing a target substance from the first part 110 through the porous membrane 102 and introducing it into a second part 120. It is configured to generate a purified target liquid F12 by removing target substances contained in F11 through the passage.
　未浄化対象液通路１１は、患者の体内から導出された未浄化対象液Ｆ１１を分離装置１００の第１部分１１０に導入するように構成されている。浄化済対象液通路１２は、浄化済対象液Ｆ１２を分離装置１００の第１部分１１０から導出させ、患者の体内に導入するように構成されている。分離装置１００は、例えば、ダイアライザにより構成され、第１部分１１０は透析膜により構成されている中空糸の内部空間であり、第２部分１２０は当該中空糸の周囲における透析液および／または再生液が流れる空間である。 The unpurified target liquid passage 11 is configured to introduce the unpurified target liquid F11 drawn out from the patient's body into the first portion 110 of the separation device 100. The purified target liquid passage 12 is configured to lead the purified target liquid F12 out of the first portion 110 of the separation device 100 and introduce it into the patient's body. Separation device 100 is composed of, for example, a dialyzer, first part 110 is an internal space of a hollow fiber composed of a dialysis membrane, and second part 120 is a dialysate and/or regenerated fluid around the hollow fiber. It is a space where things flow.
　本実施形態では、分離装置１００は第１部分１１０における未浄化対象液Ｆ１１の流れ方向と、第２部分１１０における再生液Ｆ２２の流れ方向とが対向しているまたは反対向きである「向流式分離装置」として構成されているが、他の実施形態では、分離装置１００は第１部分１１０における未浄化対象液Ｆ１１の流れ方向と、第２部分１１０における再生液Ｆ２２の流れ方向とが並行しているまたは同じ向きである「並流式分離装置」として構成されていてもよい。 In the present embodiment, the separation apparatus 100 is a "counter-flow type" in which the flow direction of the unpurified target liquid F11 in the first part 110 and the flow direction of the regenerated liquid F22 in the second part 110 are opposite or opposite. However, in other embodiments, the separation device 100 is configured such that the flow direction of the unpurified target liquid F11 in the first portion 110 and the flow direction of the regenerated liquid F22 in the second portion 110 are parallel to each other. It may also be configured as a "co-current separator" in which the two components are separated or oriented in the same direction.
　再生回路２００は、対象物質を吸着する吸着材を有している。吸着材として、活性炭や活性炭を基材とする吸着材、多孔質吸着材、陽イオン交換樹脂、陰イオン交換樹脂、ジルコニア系セラミックス、ゼオライトなどからなる吸着材、およびその混合物が採用されてもよい。再生回路２００は、濾過透析液の一部（第２の液Ｆ２１２）を吸着材と接触させることにより、対象物質の少なくとも一部を除去し、対象物質の濃度が減少した再生液Ｆ２２を生成するように構成されている。 The regeneration circuit 200 includes an adsorbent that adsorbs the target substance. As the adsorbent, activated carbon, an adsorbent based on activated carbon, a porous adsorbent, a cation exchange resin, an anion exchange resin, an adsorbent made of zirconia ceramics, zeolite, etc., and mixtures thereof may be employed. . The regeneration circuit 200 removes at least a portion of the target substance by bringing a part of the filtration dialysate (second liquid F212) into contact with an adsorbent, and generates a regenerated liquid F22 in which the concentration of the target substance is reduced. It is configured as follows.
　濾過透析液通路２１は、濾過透析液Ｆ２１を分離装置１００の第２部分１２０から導出させ、その一部である第２の液Ｆ２１２を再生回路２００に導入するように構成されている。排液通路２４は、濾過透析液通路２１から分岐し、濾過透析液Ｆ２１が分離された結果としての第１の液Ｆ２１１と第２の液Ｆ２１２とのうち、第１の液Ｆ２１１を排液として廃棄するように構成されている。排液通路２４における排液の流量（濾過透析液Ｆ２１の廃棄量）は、再生液通路２２に対する補充液（新鮮な透析液）の流入量および／または再生液通路からの再生液Ｆ２２の流出量にも基づき、分離装置１００の第２部分１２０における再生液Ｆ２２の流量に鑑みて適当に制御されてもよい。再生液通路２２は、再生液Ｆ２２を再生回路２００から分離装置１００の第２部分１２０に導入するように構成されている。 The filtered dialysate passage 21 is configured to lead out the filtered dialysate F21 from the second portion 120 of the separation device 100 and introduce a part thereof, the second liquid F212, into the regeneration circuit 200. The drain passage 24 branches from the filtration dialysate passage 21, and among the first liquid F211 and second liquid F212 resulting from separation of the filtration dialysate F21, the first liquid F211 is used as a drain liquid. Configured to be discarded. The flow rate of the drain fluid in the drain passage 24 (the amount of filtered dialysate F21 discarded) is determined by the amount of inflow of the replenisher (fresh dialysate) into the regeneration fluid passage 22 and/or the amount of outflow of the regeneration fluid F22 from the regeneration fluid passage. Based on this, the flow rate of the regenerating liquid F22 in the second portion 120 of the separation device 100 may be appropriately controlled. The regeneration liquid passage 22 is configured to introduce the regeneration liquid F22 from the regeneration circuit 200 into the second portion 120 of the separation device 100.
　第１補充液通路４１２は、第１補充液Ｆ４１を浄化済対象液通路１２に直接的に導入するように構成されている。「補充液」は、例えば新鮮な透析液や濾過用補充液を意味する。 The first replenisher passage 412 is configured to directly introduce the first replenisher F41 into the purified target liquid passage 12. "Replenishment fluid" means, for example, fresh dialysate or filtration replenishment fluid.
　（対象液浄化方法）
　前記構成の第１実施形態の対象液浄化装置によれば、次の手順で対象液浄化方法が実施される。各手順または各工程は、並行して実行されうる。分離装置１００の第１部分１１０に対して未浄化対象液Ｆ１１が導入される（Ｓ１）。対象物質を含む未浄化対象液Ｆ１１が、分離装置１００において第1部分１１０から多孔質膜１０２を通過させて第２部分１２０に導入されることで濾過透析液Ｆ２１が生成される（Ｓ２）。未浄化対象液Ｆ１１に含まれる対象物質が当該多孔質膜１０２を通過することによって除去されることで浄化済対象液Ｆ１２が生成される（Ｓ３）。浄化済対象液Ｆ１２が分離装置１００の第１部分１１０から導出される（Ｓ４）。濾過透析液Ｆ２１が分離装置１００の第２部分１２０から導出される（Ｓ５）。濾過透析液Ｆ２１が分離された結果としての第１の液Ｆ２１１と第２の液Ｆ２１２とのうち、第１の液Ｆ２１１が排液として廃棄される（Ｓ６）。第２の液Ｆ２１２が再生回路２００において吸着材と接触することにより、対象物質の少なくとも一部が第２の液Ｆ２１２から除去され、対象物質の濃度が減少した再生液Ｆ２２が生成される（Ｓ７）。再生液Ｆ２２が分離装置１００の第２部分１２０に導入される（Ｓ８）。そして、第１補充液Ｆ４１が浄化済対象液Ｆ１２に直接的に混合される（Ｓ９）。 (Target liquid purification method)
According to the target liquid purification device of the first embodiment having the above configuration, the target liquid purification method is carried out in the following steps. Each procedure or step may be performed in parallel. The unpurified target liquid F11 is introduced into the first portion 110 of the separation device 100 (S1). The unpurified target liquid F11 containing the target substance is introduced into the second part 120 from the first part 110 through the porous membrane 102 in the separation device 100, thereby generating a filtered dialysate F21 (S2). The target substance contained in the unpurified target liquid F11 is removed by passing through the porous membrane 102, thereby generating a purified target liquid F12 (S3). The purified target liquid F12 is led out from the first portion 110 of the separation device 100 (S4). The filtered dialysate F21 is led out from the second portion 120 of the separation device 100 (S5). Of the first liquid F211 and the second liquid F212 resulting from the separation of the filtered dialysate F21, the first liquid F211 is discarded as waste liquid (S6). When the second liquid F212 comes into contact with the adsorbent in the regeneration circuit 200, at least a portion of the target substance is removed from the second liquid F212, and a regenerated liquid F22 with a reduced concentration of the target substance is generated (S7 ). Regeneration liquid F22 is introduced into second portion 120 of separation device 100 (S8). Then, the first replenisher fluid F41 is directly mixed with the purified target fluid F12 (S9).
　（第２実施形態）
　図２に示されている本発明の第２実施形態としての対象液浄化装置は、第１実施形態の対象液浄化装置（図１参照）に第２補充液通路４２２が追加された構成を有している。第２補充液通路４２２は、第２補充液Ｆ４２を再生液通路２２に直接的に導入するように構成されている。第２補充液Ｆ４２および第１補充液Ｆ４１の供給源は共通の供給源であってもよく、別個の供給源であってもよい。 (Second embodiment)
A target liquid purification device as a second embodiment of the present invention shown in FIG. 2 has a configuration in which a second replenisher passage 422 is added to the target liquid purification device of the first embodiment (see FIG. 1). are doing. The second replenisher passage 422 is configured to directly introduce the second replenisher F42 into the regeneration liquid passage 22. The supply sources of the second replenisher F42 and the first replenisher F41 may be a common supply source or may be separate supply sources.
　第２実施形態の対象液浄化装置のその他の構成は、第１実施形態の対象液浄化装置の構成とほぼ同様であるため、同様の構成については同一の符号を付すとともに説明を省略する。 The other configurations of the target liquid purification device of the second embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
　（第３実施形態）
　図３に示されている本発明の第３実施形態としての対象液浄化装置は、第１実施形態の対象液浄化装置（図１参照）に再生液分岐通路２２１が追加された構成を有している。再生液分岐通路２２１は、再生液Ｆ２２の一部を未浄化対象液通路１１に直接的に導入するように構成されている。 (Third embodiment)
A target liquid purification device as a third embodiment of the present invention shown in FIG. 3 has a configuration in which a regeneration liquid branch passage 221 is added to the target liquid purification device of the first embodiment (see FIG. 1). ing. The regeneration liquid branch passage 221 is configured to directly introduce a portion of the regeneration liquid F22 into the unpurified target liquid passage 11.
　第３実施形態の対象液浄化装置のその他の構成は、第１実施形態の対象液浄化装置の構成とほぼ同様であるため、同様の構成については同一の符号を付すとともに説明を省略する。 The other configurations of the target liquid purification device of the third embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations will be given the same reference numerals and explanations will be omitted.
　（第４実施形態）
　図４に示されている本発明の第４実施形態としての対象液浄化装置は、第１実施形態の対象液浄化装置（図１参照）における第１補充液通路４１２に代えて、第１補充液通路４１１を備えている。第１補充液通路４１１は、第１補充液Ｆ４１を浄化済対象液通路１２ではなく未浄化対象液通路１１に直接的に導入するように構成されている。 (Fourth embodiment)
The target liquid purification device according to the fourth embodiment of the present invention shown in FIG. A liquid passage 411 is provided. The first replenisher passage 411 is configured to directly introduce the first replenisher F41 into the unpurified target liquid passage 11 instead of the purified target liquid passage 12.
　第４実施形態の対象液浄化装置のその他の構成は、第１実施形態の対象液浄化装置の構成とほぼ同様であるため、同様の構成については同一の符号を付すとともに説明を省略する。 The other configurations of the target liquid purification device of the fourth embodiment are almost the same as the configuration of the target liquid purification device of the first embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
　（対象液浄化方法）
　前記構成の第４実施形態の対象液浄化装置によれば、次の手順で対象液浄化方法が実施される。各手順または各工程は、並行して実行されうる。分離装置１００の第１部分１１０に対して未浄化対象液Ｆ１１が導入される（Ｓ１）。対象物質を含む未浄化対象液Ｆ１１が、分離装置１００において第1部分１１０から多孔質膜１０２を通過させて第２部分１２０に導入されることで濾過透析液Ｆ２１が生成される（Ｓ２）。未浄化対象液Ｆ１１に含まれる対象物質が当該多孔質膜１０２を通過することによって除去されることで浄化済対象液Ｆ１２が生成される（Ｓ３）。浄化済対象液Ｆ１２が分離装置１００の第１部分１１０から導出される（Ｓ４）。濾過透析液Ｆ２１が分離装置１００の第２部分１２０から導出される（Ｓ５）。濾過透析液Ｆ２１が分離された結果としての第１の液Ｆ２１１と第２の液Ｆ２１２とのうち、第１の液Ｆ２１１が排液として廃棄される（Ｓ６）。第２の液Ｆ２１２が再生回路２００において吸着材と接触することにより、対象物質の少なくとも一部が第２の液Ｆ２１２から除去され、対象物質の濃度が減少した再生液Ｆ２２が生成される（Ｓ７）。再生液Ｆ２２が分離装置１００の第２部分１２０に導入される（Ｓ８）。そして、第１補充液Ｆ４１が未浄化対象液Ｆ１１に直接的に混合される（Ｓ９’）。 (Target liquid purification method)
According to the target liquid purification device of the fourth embodiment having the above configuration, the target liquid purification method is carried out in the following steps. Each procedure or step may be performed in parallel. The unpurified target liquid F11 is introduced into the first portion 110 of the separation device 100 (S1). The unpurified target liquid F11 containing the target substance is introduced into the second part 120 from the first part 110 through the porous membrane 102 in the separation device 100, thereby generating a filtered dialysate F21 (S2). The target substance contained in the unpurified target liquid F11 is removed by passing through the porous membrane 102, thereby generating a purified target liquid F12 (S3). The purified target liquid F12 is led out from the first portion 110 of the separation device 100 (S4). The filtered dialysate F21 is led out from the second portion 120 of the separation device 100 (S5). Of the first liquid F211 and the second liquid F212 resulting from the separation of the filtered dialysate F21, the first liquid F211 is discarded as waste liquid (S6). When the second liquid F212 comes into contact with the adsorbent in the regeneration circuit 200, at least a portion of the target substance is removed from the second liquid F212, and a regenerated liquid F22 with a reduced concentration of the target substance is generated (S7 ). Regeneration liquid F22 is introduced into second portion 120 of separation device 100 (S8). Then, the first replenisher fluid F41 is directly mixed with the unpurified target fluid F11 (S9').
　（第５実施形態）
　図５に示されている本発明の第５実施形態としての対象液浄化装置は、第４実施形態の対象液浄化装置（図４参照）に第２補充液通路４２２が追加された構成を有している。第２補充液通路４２２は、第２補充液Ｆ４２を再生液通路２２に直接的に導入するように構成されている。第２補充液Ｆ４２および第１補充液Ｆ４１の供給源は共通の供給源であってもよく、別個の供給源であってもよい。 (Fifth embodiment)
The target liquid purifying device as the fifth embodiment of the present invention shown in FIG. 5 has a configuration in which a second replenisher passage 422 is added to the target liquid purifying device of the fourth embodiment (see FIG. 4). are doing. The second replenisher passage 422 is configured to directly introduce the second replenisher F42 into the regeneration liquid passage 22. The supply sources of the second replenisher F42 and the first replenisher F41 may be a common supply source or may be separate supply sources.
　第５実施形態の対象液浄化装置のその他の構成は、第４実施形態の対象液浄化装置の構成とほぼ同様であるため、同様の構成については同一の符号を付すとともに説明を省略する。 The other configurations of the target liquid purification device of the fifth embodiment are almost the same as the configuration of the target liquid purification device of the fourth embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
　（第６実施形態）
　図６に示されている本発明の第６実施形態としての対象液浄化装置は、第４実施形態の対象液浄化装置（図４参照）に再生液分岐通路２２２が追加された構成を有している。再生液分岐通路２２２は、再生液Ｆ２２の一部を浄化済対象液通路１２に直接的に導入するように構成されている。 (Sixth embodiment)
The target liquid purification device as the sixth embodiment of the present invention shown in FIG. 6 has a configuration in which a regeneration liquid branch passage 222 is added to the target liquid purification device of the fourth embodiment (see FIG. 4). ing. The regeneration liquid branch passage 222 is configured to directly introduce a portion of the regeneration liquid F22 into the purified target liquid passage 12.
　第６実施形態の対象液浄化装置のその他の構成は、第４実施形態の対象液浄化装置の構成とほぼ同様であるため、同様の構成については同一の符号を付すとともに説明を省略する。 The other configurations of the target liquid purification device of the sixth embodiment are almost the same as the configuration of the target liquid purification device of the fourth embodiment, so similar configurations are given the same reference numerals and explanations are omitted.
　（効果）
　本発明の対象液浄化装置および対象液浄化方法によれば、透析方法で使用される透析液の総量を減少させる観点から、補充液が再生回路の適当な箇所に供給される。透析液の輸送量の低減により、装置の小型化が図られ、家庭環境でも使用するのに適した構成とすることができる。 (effect)
According to the target liquid purification device and target liquid purification method of the present invention, from the viewpoint of reducing the total amount of dialysate used in the dialysis method, the replenisher is supplied to an appropriate location in the regeneration circuit. By reducing the amount of dialysate to be transported, the device can be made smaller, making it suitable for use in home environments.
　（本発明の他の実施形態）
　本発明の第１～第３実施形態の対象液浄化装置（図１～図３参照）に、本発明の第４～第６実施形態の対象液浄化装置（図４～図６参照）における第１補充液通路４１１が追加されてもよい。この場合、一対の第１補充液通路４１１および４１２のそれぞれから、未浄化対象液通路１１および浄化済対象液通路１２のそれぞれに直接的に第１補充液が供給または導入される。一対の第１補充液通路４１１および４１２のそれぞれは、共通の補充液供給源に連通していてもよく、別個の補充液供給源に連通していてもよい。 (Other embodiments of the present invention)
The target liquid purifying devices of the first to third embodiments of the present invention (see FIGS. 1 to 3) are the same as the target liquid purifying devices of the fourth to sixth embodiments of the present invention (see FIGS. 4 to 6). One replenisher passage 411 may be added. In this case, the first replenisher is directly supplied or introduced from each of the pair of first replenisher passages 411 and 412 to each of the unpurified target liquid passage 11 and the purified target liquid passage 12. Each of the pair of first replenisher passages 411 and 412 may communicate with a common replenisher supply source or may communicate with a separate replenisher supply source.
　本発明の第１～第５実施形態の対象液浄化装置（図１～図５参照）に、本発明の第６実施形態（図６参照）の再生液分岐通路２２２が追加されてもよい。本発明の第２および第４～第６実施形態の対象液浄化装置（図２および図４～図６参照）に、本発明の第３実施形態（図３参照）の再生液分岐通路２２１が追加されてもよい。 The regenerating liquid branch passage 222 of the sixth embodiment of the present invention (see FIG. 6) may be added to the target liquid purification device of the first to fifth embodiments of the present invention (see FIGS. 1 to 5). The regeneration liquid branch passage 221 of the third embodiment of the present invention (see FIG. 3) is added to the target liquid purification device of the second and fourth to sixth embodiments of the present invention (see FIGS. 2 and 4 to 6). May be added.
　１１‥未浄化対象液通路
　１２‥浄化済対象液通路
　２１‥濾過透析液通路
　２２‥再生液通路
　２４‥排液通路
１００‥分離装置
１０２‥多孔質膜
１１０‥第１部分
１２０‥第２部分
２００‥再生回路
２２１‥再生液分岐通路
２２２‥再生液分岐通路
４１１‥第１補充液通路
４１２‥第１補充液通路
４２２‥第２補充液通路
Ｆ１１‥未浄化対象液
Ｆ１２‥浄化済対象液
Ｆ２１‥濾過透析液
Ｆ２１１‥第１の液（排液）
Ｆ２１２‥第２の液
Ｆ２２‥再生液
Ｆ４１‥第１補充液
Ｆ４２‥第２補充液。 11. Unpurified target liquid passage 12. Purified target liquid passage 21. Filtered dialysate passage 22. Regeneration liquid passage 24. Drainage passage 100. Separation device 102. Porous membrane 110. First part 120. Second part 200. Regeneration circuit 221 Regeneration liquid branch passage 222 Regeneration liquid branch passage 411 First replenishment passage 412 First replenishment passage 422 Second replenishment passage F11 Unpurified target liquid F12 Purified target liquid F21 Filtration dialysate F211...First liquid (drained liquid)
F212...Second liquid F22...Regenerating liquid F41...First replenishing liquid F42...Second replenishing liquid.

Claims (4)

  1. 　未浄化対象液から少なくとも１つの対象物質を除去するための対象液浄化装置であって、
    　前記未浄化対象液に含まれる前記対象物質が通過することができる孔径を有する多孔質膜を含み、前記対象物質を含む前記未浄化対象液を、前記第1部分から前記多孔質膜を通過させて前記第２部分に導入することで濾過透析液を生成し、前記未浄化対象液に含まれる前記対象物質を当該通過によって除去することで浄化済対象液を生成する分離装置と、
    　前記未浄化対象液を前記分離装置の前記第１部分に導入するための未浄化対象液通路と、
    　前記浄化済対象液を前記分離装置の前記第１部分から導出させるための浄化済対象液通路と、
    　前記濾過透析液を前記分離装置の前記第２部分から導出させるための濾過透析液通路と、
    　前記濾過透析液通路から分岐し、前記濾過透析液が分離された結果としての第１の液と第２の液とのうち、前記第１の液を排液として廃棄するための排液通路と、
    　前記対象物質を吸着する吸着材を有し、前記濾過透析液通路から導入された前記第２の液を前記吸着材と接触させることにより、前記対象物質の少なくとも一部を前記第２の液から除去し、前記対象物質の濃度が減少した再生液を生成する再生回路と、
    　前記再生液を前記再生回路から前記分離装置の前記第２部分に導入するための再生液通路と、
    　補充液を前記未浄化対象液通路および前記浄化済対象液通路のうち少なくとも一方に直接的に導入する第１補充液通路と、を備えている
    対象液浄化装置。     A target liquid purification device for removing at least one target substance from an unpurified target liquid, comprising:
    comprising a porous membrane having a pore size through which the target substance contained in the unpurified target liquid can pass, and allowing the unpurified target liquid containing the target substance to pass through the porous membrane from the first part. a separation device that generates a filtered dialysate by introducing the dialysis fluid into the second part, and generates a purified target liquid by removing the target substance contained in the unpurified target liquid through the passage;
    an unpurified target liquid passage for introducing the unpurified target liquid into the first part of the separation device;
    a purified target liquid passage for leading out the purified target liquid from the first portion of the separation device;
    a filtrate dialysate passageway for directing the filtrate dialysate from the second portion of the separation device;
    A drainage passage branching from the filtration dialysate passage and disposing of the first liquid as a waste liquid among the first liquid and the second liquid as a result of separating the filtration dialysate; ,
    It has an adsorbent that adsorbs the target substance, and by bringing the second liquid introduced from the filtration dialysate passage into contact with the adsorbent, at least a portion of the target substance is removed from the second liquid. a regeneration circuit that removes the target substance and generates a regeneration liquid in which the concentration of the target substance is reduced;
    a regeneration liquid passageway for introducing the regeneration liquid from the regeneration circuit into the second portion of the separation device;
    A target liquid purification device comprising: a first replenisher passage that directly introduces a replenisher into at least one of the unpurified target liquid passage and the purified target liquid passage.
  2. 　請求項１に記載の対象液浄化装置において、
    　前記補充液を前記再生液通路に直接的に導入する第２補充液通路を備えている
    対象液浄化装置。     In the target liquid purification device according to claim 1,
    A target liquid purification device comprising a second replenisher passage that directly introduces the replenisher into the regeneration liquid passage.
  3. 　請求項１に記載の対象液浄化装置において、
    　前記再生液通路から前記未浄化対象液通路および前記浄化済対象液通路のうち少なくとも一方に前記再生液を導入する再生液分岐通路を備えている
    対象液浄化装置。     In the target liquid purification device according to claim 1,
    A target liquid purification device comprising a regenerating liquid branch passage that introduces the regenerating liquid from the regenerating liquid passage into at least one of the unpurified target liquid passage and the purified target liquid passage.
  4. 　未浄化対象液から少なくとも１つの対象物質を除去するための対象液浄化方法であって、
    　前記未浄化対象液に含まれる前記対象物質が通過することができる孔径を有する多孔質膜によって第１部分と第２部分とに分離されている前記分離装置の前記第１部分に対して前記未浄化対象液を導入する工程と、
    　前記対象物質を含む前記未浄化対象液を、前記第1部分から前記多孔質膜を通過させて前記第２部分に導入することで濾過透析液を生成する工程と、
    　前記未浄化対象液に含まれる前記対象物質を当該通過によって除去することで浄化済対象液を生成する工程と、
    　前記浄化済対象液を前記分離装置の前記第１部分から導出させる工程と、
    　前記濾過透析液を前記分離装置の前記第２部分から導出させる工程と、
    　前記濾過透析液が分離された結果としての第１の液と第２の液とのうち、前記第１の液を排液として廃棄する工程と、
    　前記第２の液を吸着材と接触させることにより、前記対象物質の少なくとも一部を前記第２の液から除去し、前記対象物質の濃度が減少した再生液を生成する工程と、
    　前記再生液を前記分離装置の前記第２部分に導入する工程と、
    　補充液を前記未浄化対象液および前記浄化済対象液のうち少なくとも一方に直接的に混合する工程と、を含んでいる
    対象液浄化方法。     A target liquid purification method for removing at least one target substance from an unpurified target liquid, the method comprising:
    The first part of the separation device is separated into a first part and a second part by a porous membrane having a pore size through which the target substance contained in the unpurified target liquid can pass. A step of introducing a liquid to be purified;
    generating a filtered dialysis fluid by passing the unpurified target liquid containing the target substance from the first part through the porous membrane and introducing it into the second part;
    generating a purified target liquid by removing the target substance contained in the unpurified target liquid through the passage;
    leading out the purified target liquid from the first part of the separation device;
    directing the filtered dialysate from the second portion of the separation device;
    A step of discarding the first liquid as a waste liquid among the first liquid and the second liquid as a result of separating the filtration dialysate;
    removing at least a portion of the target substance from the second liquid by bringing the second liquid into contact with an adsorbent to generate a regenerated liquid in which the concentration of the target substance is reduced;
    introducing the regeneration liquid into the second portion of the separation device;
    A method for purifying a target liquid, comprising the step of directly mixing a replenisher into at least one of the unpurified target liquid and the purified target liquid.
PCT/JP2023/029857 2022-09-06 2023-08-18 Liquid purification device and liquid purification method WO2024053363A1 (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
JPH1071201A (en) * 1996-01-19 1998-03-17 Terumo Corp Hemocatharsis drainage regenerating device, hemocatharsis liquid circuit, and hemocatharsis device
JP2015507944A (en) * 2012-01-19 2015-03-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Method and composition for removing uremic toxins in dialysis treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1071201A (en) * 1996-01-19 1998-03-17 Terumo Corp Hemocatharsis drainage regenerating device, hemocatharsis liquid circuit, and hemocatharsis device
JP2015507944A (en) * 2012-01-19 2015-03-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Method and composition for removing uremic toxins in dialysis treatment

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