WO2024044928A1

WO2024044928A1 - Reagent storage device and reagent operation system

Info

Publication number: WO2024044928A1
Application number: PCT/CN2022/115671
Authority: WO
Inventors: 谭大喜; 李开金; 李青峰
Original assignee: 深圳华大智造科技股份有限公司
Priority date: 2022-08-30
Filing date: 2022-08-30
Publication date: 2024-03-07

Abstract

A reagent storage device (1) and a reagent operation system. The reagent storage device comprises: a reagent compartment (10), comprising a compartment body (11) and a compartment door (12) for closing the compartment body (11); a kit storage unit (20), arranged inside the compartment body (11) and comprising a kit accommodating space (20A), the kit accommodating space (20A) being configured to contain a kit (30) having a reagent storage space (30A); and a puncture unit (40), comprising a sample adding needle (41) arranged inside the compartment body (11). The sample adding needle (41) has an internal channel (41A) and a puncture end (41C). The puncture end (41C) is provided with a sample adding needle hole (41B) connected to the internal channel (41A). The puncture unit (40) is movably arranged relative to the kit storage unit (20) and has a first puncture working state and a second puncture working state. The puncture unit (40) is configured as follows: in a state where the kit (30) is placed in the kit accommodating space (20A), in the first puncture working state, the sample adding needle hole (41B) is connected to the reagent storage space (30A) of the kit (30), and in the second puncture working state, the sample adding needle hole (41B) is disconnected from the reagent storage space (30A) of the kit (30).

Description

Reagent storage device and reagent operating system

Technical field

The present invention relates to the technical field of fluid manipulation, and in particular to a reagent storage device and a reagent operating system.

Background technique

In some fluid manipulation equipment, such as medical testing equipment, equipment such as biochemical and genetic sequencers require a series of physical and chemical reactions to detect samples. This series of reactions requires the addition of different reagents to assist in completion. Multiple reagents need to be added during each test, which requires a multi-channel switching valve and multiple pipelines to realize the design of the fluid flow path. In addition, a complete set of sampling mechanisms needs to be designed.

As shown in Figure 39, in the related art, an external puncture and sample addition mechanism 40' is generally provided outside the reagent compartment 10', and the external puncture and sample addition mechanism 40' is used to perform the reagent storage in the reagent compartment 10' from above. Puncture sampling.

Contents of the invention

The invention provides a reagent storage device and a reagent operating system.

A first aspect of the present disclosure provides a reagent storage device, including:

A reagent warehouse, including a warehouse body and a warehouse door for closing the warehouse body;

and

The puncture unit includes a sampling needle arranged in the chamber body. The sampling needle has an internal channel and a puncture end. The puncture end is provided with a sampling needle hole connected to the internal channel. The puncture unit The piercing unit is movably disposed relative to the reagent kit storage unit and has a first piercing working state and a second piercing working state. The piercing unit is configured to: place the reagent kit in the reagent kit accommodating space. Under the first puncture working state, the sample adding needle needle hole is connected to the reagent storage space of the kit, and in the second puncture working state, the sample adding needle needle hole is connected to the reagent storage space of the kit. The reagent storage space of the kit is disconnected.

In the reagent storage device of some embodiments, the reagent storage device includes more than two puncture units arranged corresponding to the same reagent box accommodation space.

In the reagent storage device of some embodiments,

Among the two or more puncture units corresponding to the same kit accommodation space, the puncture end of the sampling needle of at least one puncture unit is located outside or below the bottom of the corresponding kit accommodation space; and / or

Among the two or more puncture units corresponding to the same kit accommodation space, the puncture end of the sampling needle of at least one puncture unit is located outside or above the top of the corresponding kit accommodation space.

In the reagent storage device of some embodiments, the reagent kit storage unit includes a reagent kit protective part disposed between the sample addition needle and the reagent kit accommodating space, and the reagent kit protective part has a Avoid the puncture end avoidance opening of the puncture end of the sample adding needle.

In the reagent storage device of some embodiments, at least part of the sampling needle of the puncture unit includes:

a sample adding needle tube, the internal channel is located in the sample adding needle tube; and

The tip of the sampling needle is located at the puncture end of the sampling needle and is connected to one end of the sampling needle tube. The tip of the sampling needle is an end of the sampling needle tube moving away from the sampling needle tube. A cone with gradually decreasing side cross-section; wherein, the sample adding needle hole is located on the side wall of the sample adding needle tube close to the sample adding needle tip.

In the reagent storage device of some embodiments, the sampling needle includes a sampling needle tube and a sampling needle tip located at the puncture end and connected to the sampling needle tube, wherein,

The sample adding needle needle tube has at least one sample adding needle curved tube section; and/or

The sample injection needle tube has at least one flexible tube section; and/or

The sample adding needle needle tube has at least one telescopic tube section.

In the reagent storage device of some embodiments, the sample adding needle tube includes:

The first straight tube section of the sampling needle extends along the surface of the chamber wall of the chamber body; and

The second straight tube section of the sample adding needle extends from one side of the chamber wall surface of the chamber body toward the kit accommodation space. One end of the second straight tube section of the sample added needle is connected to the first straight tube section of the sample added needle. One end of the second pipe is connected through a curved pipe section of the sampling needle, and the needle tip of the pipe is connected to the other end of the straight pipe section of the second pipe.

In the reagent storage device of some embodiments, the puncture unit further includes a sampling needle mounting part, and the sampling needle is fixed on the sampling needle mounting part.

In the reagent storage device of some embodiments, the reagent storage device further includes a puncture driving unit, including a switching part drivingly connected or drivingly matched with the puncturing unit, and the switching part is configured to drive the puncturing unit at a certain position. Switch between the first puncture working state and the second puncture working state.

In the reagent storage device of some embodiments, the reagent storage device includes more than two puncture units, and the puncture drive unit includes more than two switching parts corresponding to the puncture units, wherein at least two of the switching parts Set up in conjunction.

In the reagent storage device of some embodiments, the reagent storage device includes two or more puncture units corresponding to the same reagent box accommodating space, and the puncture driving unit includes a reagent storage device corresponding to the same reagent box accommodating space. Two or more puncture units arranged correspondingly in space have one-to-one corresponding two or more switching parts, and the two or more switching parts are provided in interlocking manner, so that the corresponding two or more puncture units switch from the first to the first puncture unit. The puncture working state is synchronously switched to the second puncture working state or from the second puncture working state to the first puncture working state.

In the reagent storage device of some embodiments, the puncture unit includes a sample adding needle installation part and a plurality of the sample adding needles, the plurality of sample adding needles are installed on the sample adding needle installation part, and the switching The portion is drivingly connected or driven with the sampling needle mounting portion of the puncture unit to drive the plurality of sampling needles to move synchronously.

In the reagent storage device of some embodiments, the switching part includes a sampling needle driving mechanism configured to apply force to the puncture unit from the first puncture working state to the The force used to switch the second puncturing working state and/or the force exerted to switch from the second puncturing working state to the first puncturing working state.

In the reagent storage device of some embodiments, the sampling needle driving mechanism includes:

The first movable part has a first driving working position and a second driving working position;

The second movable part is drivingly connected or driven with the first movable part and the puncture unit to transmit the action of the first movable part to the puncture unit, wherein when the first movable part is in the position When the first driving working position is, the puncturing unit is in one of the first puncturing working state and the second puncturing working state, and when the first movable part is in the second driving working position, the puncturing unit is in one of the first puncturing working state and the second puncturing working state. The puncturing unit is in the other one of the first puncturing working state and the second puncturing working state.

In the reagent storage device of some embodiments, the puncture driving unit includes a linkage part, and the linkage part is drivingly connected or driven with at least two of the switching parts to synchronize the puncture units corresponding to the at least two switching parts. sports.

In the reagent storage device of some embodiments, the puncture drive unit includes:

a limiting portion configured to limit the range of movement of the first movable portion and/or the second movable portion; and/or

A guide part configured to guide the movement of the first movable part and/or the second movable part.

In the reagent storage device of some embodiments,

The limiting part is configured to limit the movement range of the linkage part to limit the movement range of the first movable part and/or the second movable part; and/or

The guide part is configured to guide the movement of the linkage part and the first movable part and/or the second movable part.

In the reagent storage device of some embodiments,

The limiting part includes one or more limiting structures, at least one of the limiting structures includes a limiting groove and a limiting surface, and the limiting surface is movably located in the limiting groove and connected with the limiting surface. The position groove has an abutting state, one of the limiting groove and the limiting surface is fixed relative to one of the first movable part and the second movable part, and the other one is fixed relative to the first movable part. part and the other one of the second movable part is fixed; and/or

The guide part includes one or more guide structures, at least one guide structure includes a guide groove and a guide surface, the guide surface is in sliding fit with the guide groove, and one of the guide groove and the guide surface is relative to the guide surface. The warehouse body is fixed, and the other one is fixed relative to the first movable part or the second movable part.

In the reagent storage device of some embodiments, the puncture driving unit further includes a positioning portion, the positioning portion has a function to maintain the puncture unit in the first puncture working state and/or the second puncture working state. A positioning state and an avoidance state that prevents interference with the switching working position of the puncture unit, and the positioning part is movably disposed relative to the cartridge body to switch between the avoidance state and the positioning state.

In the reagent storage device of some embodiments, the positioning part is drivingly matched with the reagent box to switch between the avoidance state and the positioning state driven by the reagent box.

In the reagent storage device of some embodiments, the positioning part includes a slider and a slider reset mechanism. The slider is movably installed in the cartridge body relative to the cartridge body and includes a positioning surface. The block is driven and matched with the reagent box. In the avoidance state of the positioning part, the slider is in the avoidance position where the positioning surface is separated from the second movable part, and the slider reset mechanism is in a force-accumulating state. state, in the positioning state of the positioning part, the slider is in a positioning position where the positioning surface is in contact with the second movable part, and the slider return mechanism is in a force release state.

In the reagent storage device of some embodiments,

The first movable part includes a first translation component, the first translation component is disposed reciprocally in a first direction relative to the cartridge body, the first translation component is provided with a driving surface, and the driving surface is arranged along a first direction. The first direction is inclined toward a second direction perpendicular to the first direction;

The second movable part includes a second translation component, which is fixedly arranged relative to the sampling needle and reciprocally movable in the second direction relative to the cartridge body. The two translation components are provided with mating surfaces corresponding to the driving surfaces, the mating surfaces are inclined along the first direction toward the second direction, and the position of the first translation component in the first direction is changed by changing the position of the first translation component in the first direction. The mating position of the driving surface and the mating surface changes the position of the second translation component along the second direction.

In the reagent storage device of some embodiments, the puncture driving unit includes a linkage portion, the linkage portion is drivingly connected with at least two switching portions or drivingly engages the at least two switching portions so that the at least two switching portions The puncture units corresponding to the switching part move synchronously, where,

The linkage part includes a push-pull rod extending along the first direction;

The first translation component is fixed on the push-pull rod, and the driving surface is provided on a side of the push-pull rod close to the second translation component;

The second translation component includes a pressure plate, the pressure plate is arranged along the second direction, and the mating surface is provided at an end of the pressure plate close to the first translation component.

In the reagent storage device of some embodiments,

The puncture driving unit includes a limiting portion configured to limit the movement range of the linkage portion to limit the movement range of the first movable portion, and the limiting portion includes one or more limiting portions. structure, at least one of the limiting structures includes a limiting groove and a limiting surface, the limiting surface is movably located in the limiting groove and has an abutting state with the limiting groove, the limiting groove and one of the limiting surfaces is provided on the second movable part, and the other is provided on the push-pull rod; and/or

The puncture driving unit includes a guide portion configured to guide the movement of the linkage portion to guide the movement of the first movable portion. The guide portion includes one or more guide structures, at least one The guide structure includes a guide groove and a guide surface. One of the guide groove and the guide surface is fixed relative to the cartridge body, and the other is provided on the push-pull rod.

In the reagent storage device of some embodiments,

The first movable part includes a first rotating component, and the first rotating component is rotatably arranged relative to the cartridge body;

The second movable part includes a second rotating component. The second rotating component is rotatably arranged relative to the warehouse body and is drivingly connected or driven with the first rotating component. The second rotating component drives the The puncture unit switches between the first puncture working state and the second puncturing working state.

In the reagent storage device of some embodiments,

The first rotating component is a rotating shaft;

The second rotating component includes a cam disposed on the rotating shaft, and the cam is press-fitted with the puncture unit.

In the reagent storage device of some embodiments, the puncture driving unit further includes a movable connection part, the movable connection part is respectively connected to the cam and the puncture unit, and is configured to transmit the movement of the cam to the puncture unit. The puncture unit is configured so that the rotation of the cam drives the puncture unit to move.

In the reagent storage device of some embodiments, the movable connection part includes:

A first pin is provided on the end face of the cam;

a second pin, arranged on the puncture unit at a parallel distance from the first pin;

The movable element has an arc-shaped groove. The movable element is mounted on the cam and the puncture unit through the first pin and the second pin in cooperation with the arc-shaped groove. The first pin and the second pin is in sliding fit with the arc-shaped groove.

In the reagent storage device of some embodiments,

The puncture driving unit includes a linkage part, which is drivingly connected or driven with at least two of the switching parts to cause the puncture units corresponding to the at least two switching parts to move synchronously;

The linkage part includes at least one of a belt transmission mechanism, a chain transmission mechanism, a gear transmission mechanism, a gear and rack transmission mechanism or a linkage mechanism connected between the first rotating components of the at least two switching parts.

In the reagent storage device of some embodiments, the puncture driving unit further includes an actuating part, the actuating part is drivingly connected or drivingly matched with the first movable part; the actuating part includes:

A handle or a rotating handle is drivingly connected or matched with the first movable part, and the handle or rotating handle is provided on the side of the warehouse body where the door is provided; or

The actuator is drivingly connected or drivingly matched with the first movable part.

In the reagent storage device of some embodiments, the switching part includes a sample needle reset mechanism, wherein,

One of the sampling needle driving mechanism and the sampling needle reset mechanism is configured to apply a force to the puncture unit to switch it from the first puncture working state to the second puncturing working state;

The other one of the sample adding needle driving mechanism and the sample adding needle reset mechanism is configured to apply a force to the puncturing unit to switch from the second puncturing operating state to the first puncturing operating state.

In the reagent storage device of some embodiments, the sampling needle reset mechanism includes at least one spring; wherein,

The spring is located and/or connected between the puncture unit and the kit storage unit; or

The spring is located and/or connected between the puncture unit and the cartridge body.

In the reagent storage device of some embodiments, the reagent storage device includes a plurality of the reagent kit storage units, and/or the reagent kit storage unit includes a plurality of the reagent kit storage spaces.

In the reagent storage device of some embodiments, the reagent storage device further includes a thermal insulation unit configured to maintain a temperature of the reagent compartment.

In the reagent storage device of some embodiments, the heat preservation unit includes a refrigerant circulation system, and the refrigerant circulation system is configured to regulate the temperature inside the reagent compartment.

In the reagent storage device of some embodiments,

The reagent storage device includes a reagent box, the reagent box includes a reagent storage space, and the reagent box accommodation space of the reagent storage device is used to place the reagent box;

In the first puncture working state of the puncture unit, the needle hole of the sampling needle is connected to the reagent storage space of the kit placed in the kit accommodation space. In the second puncture working state, the needle hole of the sampling needle is disconnected from the reagent storage space of the reagent kit placed in the reagent kit accommodation space.

In the reagent storage device of some embodiments, the reagent box has a weak portion corresponding to the puncture end of the sample adding needle. In the first puncture working state of the puncture unit, the puncture end of the sample adding needle The end enters the reagent storage space by piercing the weak portion to realize communication between the sample adding needle hole of the sample adding needle and the reagent storage space of the kit.

In some embodiments, the reagent storage device further includes a bottom plate located in the reagent compartment and installed on the bottom wall of the compartment body, and the reagent box storage unit and/or the puncture unit are installed on the base plate.

A second aspect of the disclosure provides a reagent operating system, including the reagent storage device described in the first aspect of the disclosure; wherein the reagent operating system further includes:

The reagent receiving part is in communication with the internal channel of the sampling needle of at least one of the puncture units; and/or

The cleaning liquid delivery part is in communication with the internal channel of the sampling needle of at least one puncture unit; and/or

The gas communication portion is in communication with the internal channel of the sampling needle of at least one puncture unit.

In some embodiments of the reagent operating system,

The reagent operating system includes the reagent receiving part and the cleaning liquid delivery part. The reagent receiving part and the cleaning liquid delivery part are respectively connected to the internal channels of the sampling needles of different puncture units. status; and/or

The reagent operating system includes the cleaning liquid transport part and the gas communication part. The cleaning liquid transport part and the gas communication part are in different periods of time with the internal channel of the sampling needle of the same puncture unit. Connectivity status.

In the reagent operating system of some embodiments, the reagent operating system includes the reagent receiving part and the cleaning liquid delivery part, wherein,

The puncture end of the sampling needle of the puncture unit that is in communication with the reagent receiving part is located outside or below the bottom of the corresponding reagent box accommodation space;

The puncture end of the sampling needle of the puncture unit that is in communication with the cleaning fluid delivery part is located outside or above the top of the corresponding kit accommodation space.

In some embodiments of the reagent operating system,

The reagent receiving part is connected to the sampling needle of at least one puncture unit through a connecting tube with a flexible tube section or a telescopic tube section; and/or

The cleaning liquid delivery part is connected to the sampling needle of at least one puncture unit through a connecting tube with a flexible tube section or a telescopic tube section; and/or

The gas communication part is connected to the sampling needle of at least one puncture unit through a connecting tube having a flexible tube section or a telescopic tube section.

In some embodiments of the reagent operating system,

The reagent receiving part is connected to the sampling needle of at least one puncture unit through a connecting tube that passes through the cartridge body and is sealed between the cartridge body; and/or

The cleaning liquid delivery part is connected to the sampling needle of at least one puncture unit through a connecting pipe that passes through the cartridge body and is sealed between the cartridge body; and/or

The gas communication part is connected to the sampling needle of at least one puncture unit through a connecting tube that passes through the cartridge body and is sealed between the cartridge bodies.

In the reagent storage device provided by the present disclosure, a puncture unit is provided in the reagent compartment. The sampling needle hole of the puncture unit's sampling needle can be connected or disconnected from the reagent storage space of the reagent box, so that the puncture unit can realize external sampling. The function of the mechanism couples the puncture unit to the inside of the reagent compartment. Compared with the existing technology of installing a sampling mechanism outside the reagent compartment, there is no need to reserve multiple through holes on the reagent compartment for the sampling needle to pass through, which is conducive to The internal accommodation space of the reagent compartment and the reagent box and puncture unit in the reagent compartment are isolated from the air. Therefore, it is helpful to avoid a large amount of air entering the reagent compartment to form condensed water and then carrying dust and impurities and falling into the reagent kit to contaminate the reagents.

The reagent operating system of the present disclosure has the same advantages as the reagent storage device of the present disclosure.

Description of drawings

The drawings described here are used to provide a further understanding of the present invention and constitute a part of the present disclosure. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached picture:

Figure 1 is a schematic structural diagram of a reagent storage device according to an embodiment of the present disclosure.

FIG. 2 is a schematic structural diagram of the reagent storage device shown in FIG. 1 from another direction.

Figure 3 is a schematic structural diagram of the reagent storage device shown in Figure 1, in which one reagent box is located outside the reagent box accommodation space.

FIG. 4 is a schematic structural diagram of the reagent storage device shown in FIG. 1 with the reagent compartment removed, in which one reagent box is located outside the reagent compartment.

FIG. 5 is a schematic structural diagram of the reagent storage device shown in FIG. 1 with the reagent compartment removed.

Figure 6 is a schematic structural diagram of the reagent storage device shown in Figure 1 from another direction, with the reagent compartment removed, in which one reagent box is located outside the reagent box containing space.

FIG. 7 is a schematic top structural view of the reagent storage device shown in FIG. 1 with the reagent compartment removed.

FIG. 8 is a schematic cross-sectional structural view of the reagent storage device shown in FIG. 1 with the reagent compartment removed.

Figure 9 is a schematic structural diagram of the reagent storage device shown in Figure 1 from another direction, with the reagent compartment and bottom plate removed, in which one reagent box is located outside the reagent box accommodation space.

FIG. 10 is a schematic structural diagram of the combined structure of the reagent box storage unit, reagent box, puncture unit and puncture drive unit of the reagent storage device shown in FIG. 1 , wherein the puncture unit is in the second puncture working state.

FIG. 11 is a partially enlarged structural schematic diagram of a part of FIG. 10 .

FIG. 12 is a schematic structural diagram of the positioning portion of the puncture driving unit of the reagent storage device shown in FIG. 1 .

FIG. 13 is a partially enlarged structural schematic diagram of another part of FIG. 10 .

Figure 14 is a schematic structural diagram of the combined structure of the reagent cartridge storage unit, reagent cartridge, puncture unit and puncture drive unit of the reagent storage device shown in Figure 1, wherein the puncture unit is in the first puncture working state.

FIG. 15 is a partial structural diagram of a part of FIG. 14 .

FIG. 16 is a partially enlarged structural diagram of another part of FIG. 14 .

FIG. 17 is a schematic structural diagram of the sampling needle of the puncture unit of the reagent storage device shown in FIG. 1 .

FIG. 18 is a schematic cross-sectional structural view of the sample adding needle shown in FIG. 11 in another direction.

FIG. 19 is an exploded structural diagram of the reagent box of the reagent storage device shown in FIG. 1 .

Figure 20 is a schematic structural diagram of a reagent storage device according to another embodiment of the present disclosure.

FIG. 21 is a schematic structural diagram of the reagent storage device shown in FIG. 20 from another direction.

Figure 22 is a schematic structural diagram of the reagent storage device shown in Figure 20, in which one reagent box is located outside the reagent box containing space.

FIG. 23 is a schematic structural diagram of the reagent storage device shown in FIG. 20 with the reagent compartment removed.

FIG. 24 is a schematic structural diagram of the reagent storage device shown in FIG. 20 , with the reagent compartment and insulation unit removed.

FIG. 25 is a schematic structural diagram of the reagent storage device shown in FIG. 20 from another direction.

Figure 26 is a schematic structural diagram of the reagent storage device shown in Figure 20 with the reagent compartment removed, in which one reagent box is located outside the reagent compartment.

FIG. 27 is a schematic structural diagram of the reagent storage device shown in FIG. 20 from another direction, with the reagent compartment removed.

FIG. 28 is a schematic structural diagram of the reagent storage device shown in FIG. 20 from another direction, with the reagent compartment removed.

FIG. 29 is an exploded structural diagram of the reagent storage device shown in FIG. 20 with the reagent compartment removed.

FIG. 30 is a partially enlarged structural schematic diagram of FIG. 29 .

FIG. 31 is a schematic top structural view of the reagent storage device shown in FIG. 20 .

FIG. 32 is a schematic cross-sectional structural diagram along the line A-A in FIG. 31 .

FIG. 33 is a schematic top structural view of the reagent storage device shown in FIG. 20 with the reagent compartment removed.

Fig. 34 is a schematic three-dimensional structural diagram of the cross-section taken along B-B in Fig. 33.

Fig. 35 is a schematic structural diagram of a partial structure of the reagent storage device shown in Fig. 20, including a puncture unit, a puncture drive unit and a reagent box.

FIG. 36 is a schematic structural diagram of a partial structure of the reagent storage device shown in FIG. 20 including a puncture unit and a puncture drive unit.

FIG. 37 is an exploded structural diagram of part of the structure shown in FIG. 36 .

Figure 38 is a schematic diagram of a reagent operating system according to an embodiment of the present disclosure.

Figure 39 is a schematic structural diagram of a reagent operating system in the related art.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application or uses. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.

The relative arrangement of components and steps, numerical expressions, and numerical values set forth in these examples do not limit the scope of the invention unless specifically stated otherwise. At the same time, it should be understood that, for convenience of description, the dimensions of various parts shown in the drawings are not drawn according to actual proportional relationships. Techniques, methods and devices known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, such techniques, methods and devices should be considered part of the authorized specification. In all examples shown and discussed herein, any specific values are to be construed as illustrative only and not as limiting. Accordingly, other examples of the exemplary embodiments may have different values. It should be noted that similar reference numerals and letters refer to similar items in the following figures, so that once an item is defined in one figure, it does not need further discussion in subsequent figures.

In the process of realizing the present disclosure, the inventor discovered that the following phenomena exist in related technologies:

The external sample adding mechanism 40' is installed outside the reagent compartment 10', which cannot be well isolated from the air and generates a lot of condensed water. Specifically, the reagent chamber 10' has a refrigeration function, and a plurality of through holes are provided at the top for the sampling needle 41' to pass through. The outside atmosphere can easily enter the reagent chamber 10' through the through holes to form condensation water and carry dust and impurities. Contaminated reagents dropped into the kit.

When the external sample adding mechanism 40' is installed, the total volume of the sample adding mechanism 40' and the reagent chamber 10' is too large.

It is difficult to realize automatic cleaning of the sample adding needle 41' of the sample adding mechanism 40' or it is difficult to clean it automatically.

In order to solve the aforementioned problems, embodiments of the present disclosure provide a reagent storage device 1 and a reagent operating system.

As shown in FIGS. 1 to 37 , the reagent storage device 1 according to the embodiment of the present disclosure includes a reagent compartment 10 , a reagent box storage unit 20 and a puncture unit 40 . The reagent compartment 10 includes a compartment body 11 and a compartment door 12 for closing the compartment body 11 . The reagent kit storage unit 20 is provided in the cartridge body 11 and includes a reagent kit storage space 20A. The reagent kit storage space 20A is configured to place the reagent kit 30 having a reagent storage space 30A. The puncture unit 40 includes a sampling needle 41 disposed in the cartridge body 11 . The sampling needle 41 has an internal channel 41A and a puncture end 41C. The puncture end 41C is provided with a sampling needle hole 41B that communicates with the internal channel 41A. The puncture unit 40 is movably disposed relative to the kit storage unit 20 and has a first puncture working state and a second puncturing working state. The puncture unit 40 is configured such that, with the reagent kit 30 placed in the reagent kit accommodation space 20A, in the first puncture working state, the sampling needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30, and in the second puncture working state, the puncture unit 40 is configured to In the puncture working state, the needle hole 41B of the sampling needle is disconnected from the reagent storage space 30A of the reagent box 30 .

In the reagent storage device 1 of the embodiment of the present disclosure, a puncture unit 40 is provided in the reagent chamber 10. The sample needle hole 41B of the sample needle 41 of the puncture unit 40 can be connected or disconnected from the reagent storage space 30A of the reagent box 30. Therefore, the puncture unit 40 can realize the function of an external sample adding mechanism, and the puncture unit 40 is coupled to the inside of the reagent compartment 10. Compared with the existing technology of installing a sample adding mechanism externally on the reagent compartment 10, there is no need to pre-install the sample on the reagent compartment 10. Leaving a plurality of through holes for the sampling needle to pass through is conducive to isolating the internal accommodation space of the reagent chamber 10 and the reagent box 30 and puncture unit 40 from the air. Therefore, it is helpful to avoid a large amount of air entering the reagent chamber to form condensation water. Carrying dust and impurities fall into the kit and contaminate the reagents.

In the embodiment shown in FIGS. 1 to 37 , the reagent compartment 10 includes a compartment body 11 and a compartment door 12 for closing the compartment body 11 . The compartment body 11 and the compartment door 12 form an internal storage space of the reagent compartment 10 . The bin body 11 is, for example, a cube with an opening facing one side of the bin body 11 . In embodiments not shown, the cartridge body 11 may be configured in other shapes, such as cylindrical shape.

As shown in the embodiments shown in FIGS. 1 to 37 , in the reagent storage device 1 of some embodiments, the compartment door 12 is hinged with the compartment body 11 . The opening of the warehouse body 11 faces the side of the warehouse body 11 , and the warehouse door 12 is hinged to one side of the warehouse body 11 . In an embodiment not shown in the figures, the warehouse body 11 and the warehouse door 12 can be hingedly connected to the top surface of the warehouse body 11 , or the warehouse body 11 and the warehouse door 12 can also be detachably connected through buckles or other means to realize the connection of the warehouse body 11 On and off.

The reagent kit 30 may include only one reagent storage space 30A, or may include multiple reagent storage spaces 30A. For example, in the embodiment shown in FIGS. 1 to 37 , the number of reagent storage spaces 30A is multiple. When the reagent kit 30 has multiple reagent storage spaces 30A, the reagent kit 30 may only have a single reagent kit body 31 , and the multiple reagent storage spaces are separated into multiple reagent storage spaces by partition walls in the single reagent kit body 31 . When the kit 30 has multiple reagent storage spaces 30A, the kit 30 may also include multiple reagent kit bodies 31. Among the multiple reagent kit bodies 31, each reagent kit body 31 may only include a single reagent storage space. It is also possible that part of the reagent kit body 31 includes a single reagent storage space, and another part of the reagent kit body 31 includes multiple reagent storage spaces, or all of the reagent kit bodies 31 include multiple reagent storage spaces.

As shown in the embodiments shown in FIGS. 1 to 37 , in the reagent storage device 1 of some embodiments, the reagent kit 30 included in the reagent storage device 1 or used in conjunction with the reagent storage device 1 includes a plurality of reagent kit boxes 31 , each reagent box body 31 has a single reagent storage space 30A.

In the various embodiments of the present disclosure, "multiple" refers to two or more, such as two, three, five, eight, thirteen, etc.

In the reagent storage device 1 of some embodiments, the reagent storage device 1 includes more than two puncture units 40 arranged corresponding to the same reagent cartridge accommodation space 20A. For example, in the embodiment shown in FIGS. 1 to 37 , two puncture units 40 are provided corresponding to the same kit accommodation space 20A.

The reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent box storage space 20A. The sampling needles 41 of different puncture units 40 can be connected to the required functional modules according to different needs, such as reagent receiving parts and cleaning fluids. A transport part or a gas communication part, etc., to implement different functions such as sampling, improving the working efficiency of the sampling needle 41 or cleaning the sampling needle 41 .

In the reagent storage device 1 of some embodiments, among the two or more puncture units 40 provided corresponding to the same reagent kit accommodation space 20A, the puncture end 41C of the sampling needle 41 of at least one puncture unit 40 is located in the corresponding reagent kit container. outside or below the bottom of the storage space 20A; and/or among two or more puncture units 40 corresponding to the same kit storage space 20A, the puncture end 41C of the sampling needle 41 of at least one puncture unit 40 is located in the corresponding kit. Outside or above the top of the accommodation space 20A.

This arrangement facilitates two or more puncture units 40 corresponding to the same kit accommodation space 20A to assume different functions. The puncture end 41C of the sampling needle 41 of the puncture unit 40 is located outside the bottom of the corresponding kit accommodation space 20A or When the puncture unit 40 moves downward, a small movement of the puncture unit 40 can realize the connection and disconnection between the puncture needle hole 41B of the puncture end 41C and the reagent storage space 30A of the reagent box 30, and can realize the evacuation of the reagent in the reagent storage space 30A; puncture When the puncture end 41C of the puncture needle 41 of the unit 40 is located outside or above the top of the corresponding kit accommodation space 20A, a small movement of the puncture unit 40 can realize the connection between the puncture needle hole 41B of the puncture end 41C and the kit 30. The connection and disconnection of the reagent storage space 30A can realize the injection of reagents, cleaning liquid or gas into the reagent storage space 30A. Since the corresponding puncture unit 40 only needs a small movement, there is no need to reserve a large movable space for the puncture unit, which is beneficial to miniaturization of the reagent storage device.

In the embodiment shown in FIGS. 1 to 37 , two upper and lower puncture units 40 are provided corresponding to each kit accommodation space 20A. Among them, the puncture end 41C of the sampling needle 41 of the puncture unit 40 located below is located below the corresponding kit accommodation space 20A. The puncture unit 40 located below is used to discharge the reagents in the reagent kit 30 . The puncture end 41C of the sampling needle 41 of the puncture unit 40 located above is located above the corresponding kit accommodation space 20A. The puncture unit 40 located above can be used to communicate with the gas when the puncture unit 40 located below exports the reagents of the kit 30 to smoothly export the reagents, and can also be used to provide reagents after the puncture unit 40 located below exports the reagents of the kit 30 The cleaning liquid is passed into the storage space 30A to clean the sampling needle 41 of the puncture unit 40 located below.

In the reagent storage device 1 of some embodiments, the reagent kit storage unit 20 includes a reagent kit protection part 21 disposed between the sampling needle 41 and the reagent kit accommodation space 20A. The puncture end 41C of the sample needle 41 has an escape opening 21A.

The kit protection part 21 is provided to easily protect the kit 30 and prevent the kit 30 from touching the sampling needle 41 when entering the kit storage space 20A. It also facilitates the accurate positioning of the kit 30 inside the kit storage unit 20 , so that when the puncture unit 40 switches its working position, the sample needle hole 41B of the sample needle 41 can be accurately connected or disconnected from the corresponding reagent storage space 30A according to the working position of the puncture unit 40 .

The reagent cartridge protective part 21 is, for example, a reagent cartridge protective plate. As shown in the embodiment shown in FIGS. 1 to 37 , each kit storage unit 20 includes two upper and lower square kit protection plates spaced parallelly, and a connecting rod 22 is respectively provided at the four corners of the upper and lower kit protection plates. , each connecting rod 22 is fixedly connected to the upper and lower kit protective plates. Each connecting rod 22 passes through the upper and lower kit protective plates. The upper and lower ends of the connecting rod 22 are respectively located above and below the upper and lower kit protective plates. In embodiments not shown in the figures, the kit protection part 21 may also be in the form of a mesh plate, a frame, a track, or other forms.

In the reagent storage device 1 of some embodiments, as shown in FIGS. 17 and 18 , at least part of the sampling needle 41 of the puncture unit 40 includes a sampling needle tube 411 and a sampling needle tip 412 . The internal channel 41A is located in the sample adding needle tube 411 . The sampling needle tip 412 is located at the puncture end 41C of the sampling needle 41 and is connected to one end of the sampling needle tube 411. The cross section of the sampling needle tip 412 gradually decreases from the sampling needle tube 411 to the side away from the sampling needle tube 411. Small cones. The sample adding needle hole 41B is located on the side wall of the sample adding needle tube 411 close to the sample adding needle tip 412 .

The structure of the sampling needle 41 facilitates the design of the sampling needle hole 41B of the sampling needle 41 to be closer to the wall or adjacent wall of the reagent storage space 30A that is pierced by the sampling needle 41 , so that the sampling needle 41 When it is located outside or below the bottom of the reagent storage space 30A, it is conducive to the complete flow out of the reagents in the reagent storage space 30A. When the sampling needle 41 is located outside or above the top of the reagent storage space 30A, it is conducive for gas or cleaning agent to enter the reagent storage space 30A. Inside.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 17-18, 23-24, 26-29, and 32-37, the sampling needle 41 includes a sampling needle The needle tube 411 and the sampling needle tip 412 located at the puncture end 41C and connected to the sampling needle tube 411; wherein the sampling needle tube 411 has at least one sampling needle bent tube section 4112; and/or the sampling needle tube 411 has at least one Flexible tube section; and/or the sampling needle needle tube 411 has at least one telescopic tube section.

The sampling needle tube 411 is provided with at least one sampling needle curved tube section 4112, which is conducive to reasonably setting the shape of the sampling needle 41 according to the surrounding environment of the sampling needle 41, saving the space occupied by the sampling needle 41 and its required activity space, and is conducive to reducing Small reagent storage device 1 size and cost.

The sampling needle tube 411 has at least one flexible tube section and/or the sampling needle tube 411 has at least one telescopic tube section, which is beneficial to prevent the structure of the sampling needle 41 from being damaged or the external parts connected to the sampling needle when the puncture unit 40 switches the working state. affected.

In the reagent storage device 1 of some embodiments, as shown in Figures 17-18, the sampling needle tube 411 includes a first sampling needle straight tube section 4111, a sampling needle curved tube section 4112, and a second sampling needle straight tube section 4113. The first straight tube section 4111 of the sample adding needle extends along the surface of the chamber wall of the chamber body 11 . The second sample adding needle straight tube section 4113 extends from the side of the chamber wall surface of the chamber body 11 toward the kit accommodating space 20A. One end of the second sampling needle straight tube section 4113 is connected to one end of the first sampling needle straight tube section 4111 through a sampling needle curved tube section 4112, and the sampling needle tip 412 is connected to the other end of the second sampling needle straight tube section 4113.

The above arrangement is conducive to rationally saving the space occupied by the sampling needle 41 and its activity space with the minimum bent pipe section.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 17-18, 23-24, 26-29, and 32-37, the puncture unit 40 further includes a sampling needle The sampling needle 41 is fixed on the mounting part 42 .

The sampling needle mounting part 42 may be, for example, a mounting plate, a mesh plate, a mounting frame, a mounting rod, or the like. In the embodiment shown in FIGS. 1 to 37 , the loading needle mounting portion 42 is a mounting plate. The sample adding needle 41 is installed on the sample adding needle mounting part 42 through its fixed connection part 413.

Providing the sampling needle mounting part 42 facilitates accurate positioning of the sampling needle 41 and driving the sampling needle mounting part 42 to switch the puncture unit 40 between the first puncture working state and the second puncture working state, thereby also facilitating accurate control. The working position of the sample adding needle 41 is also conducive to reducing damage to the sample adding needle 41 .

In the reagent storage device 1 of some embodiments, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the reagent storage device 1 further includes a puncture driving unit 50. The puncture driving unit 50 includes a switching part 51, which is drivingly connected or driven with the puncture unit 40, and is configured to drive the puncture unit 40 to switch between the first puncture working state and the second puncture working state.

Providing the switching part 51 is convenient for driving the puncture unit 40 to switch between the first puncture working state and the second puncturing working state.

In the reagent storage device 1 of some embodiments, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the reagent storage device 1 includes more than two puncture units 40. When the reagent storage device 1 includes two or more puncture units 40, the reagent storage device 1 includes two or more switching parts 51, and the two or more switching parts 51 are drivingly connected or drivingly matched with the two or more puncture units 40 in one-to-one correspondence.

This arrangement facilitates controlling the actions of each puncture unit 40 through the switching part 51 to accurately and/or quickly realize the actions required by each puncture unit 40.

In the reagent storage device 1 of some embodiments, as shown in Figure 1, Figure 3-16, Figure 20, Figure 22-30, and Figure 32-37, the reagent storage device 1 includes more than two puncture units 40, a puncture drive unit 50 includes two or more switching parts 51 corresponding to the puncture unit 40, wherein at least two switching parts 51 are provided in interlocking manner.

At least two switching parts 51 are provided in conjunction, which facilitates the use of fewer operating steps to achieve the required action switching of the puncture unit 40.

As shown in the embodiment shown in FIGS. 1 to 37 , the reagent storage device 1 includes four puncture units 40 . The reagent storage device 1 has two reagent kit accommodating spaces 20A, and each reagent kit accommodating space 20A has two reagent kit accommodating spaces 20A on its upper and lower sides. A puncture unit 40 is arranged. The reagent storage device 1 includes four switching parts 51. Each reagent box accommodation space 20A is provided with two puncture units 40 and two switching parts 51. The two switching parts 51 corresponding to the same reagent box accommodation space 20A are provided in conjunction with each other. The two puncturing units 40 corresponding to the same reagent cartridge accommodating space 20A are driven simultaneously.

In some embodiments of the reagent storage device 1 , the reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent box accommodation space 20A, and the puncture driving unit 50 includes one or more puncture units 40 arranged corresponding to the same reagent box accommodation space 20A. The two or more puncture units 40 have one-to-one correspondence and the two or more switching parts 51 are provided in conjunction, so that the corresponding two or more puncture units 40 can synchronously switch from the first puncture operation state to the second puncture operation. state or synchronously switches from the second puncture working state to the first puncture working state.

The two or more switching parts 51 corresponding to the two or more puncture units 40 corresponding to the same kit accommodation space 20A are provided in conjunction with each other, so that the corresponding two or more puncture units 40 can synchronously switch from the first puncture operating state to the second The puncture working state or the synchronous switching from the second puncture working state to the first puncture working state is conducive to synchronously switching the working positions of the puncture units 40 corresponding to the same kit accommodation space 20A, thereby simplifying the operation steps and different puncture units 40 The corresponding relationship between the working positions is accurate, which helps to reduce operating errors.

In the embodiment shown in FIGS. 1 to 37 , the two puncture units 40 corresponding to the same kit accommodating space 20A synchronously switch from the first puncture working state to the second puncture working state under the linkage action of the two corresponding switching parts 51 . the second puncture working state, and synchronously switches from the second puncture working state to the first puncture working state.

In the reagent storage device 1 of some embodiments, as shown in Figures 1, 3-16, 20, 22-30, and 32-37, the puncture unit 40 includes a sample adding needle mounting portion 42 and a plurality of sample adding needles. Needle 41, multiple sampling needles 41 are installed on the sampling needle mounting part 42, and the switching part 51 is drivingly connected or driven with the sampling needle mounting part 42 of the puncture unit 40 to drive the multiple sampling needles 41 to move synchronously.

This arrangement facilitates the switching part 51 to drive multiple sampling needles 41 to move synchronously, improves the switching efficiency of the working position of the puncture unit 40, and enables each sampling needle 41 to synchronously connect or disconnect with the corresponding reagent storage space 30A.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-10, 14, 23-24, 26-29, 32, and 34-37, the switching part 51 includes Sample needle driving mechanism 511. Wherein, the sampling needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch from the first puncture working state to the second puncture working state and/or to apply a force to switch the puncturing unit 40 from the second puncturing working state to the first puncture working state. The force of state switching.

In the embodiment shown in FIGS. 1 to 37 , the sampling needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-11, 13-16, 23-24, 26-30, and 32-37, the sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is drivingly connected or driven with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first puncturing working state and the second puncturing state. In one of the working states, when the first movable part 5111 is in its second driving working position, the lancing unit 40 is in the other of its first lancing working state and its second lancing working state.

The sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112, which facilitates flexible setting of the sampling needle driving mechanism 511. For example, the switching part 51 can be changed through the setting of the first movable part 5111 and the second movable part 5112. The direction and magnitude of the force at the input end and the force at the output end are conducive to realizing the linkage between the switching parts 51 and the limiting, guiding, positioning and other functions of the switching part 51 .

In the embodiment shown in FIGS. 1 to 37 , the sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112 . The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is drivingly connected or driven with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first puncture working state. When the movable part 5111 is in its second driving working position, the puncturing unit 40 is in the second puncturing working state.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-10, 13-16, 23-24, 26-30, and 32-37, the puncture driving unit 50 includes The linkage part 52 is drivingly connected or driven with the at least two switching parts 51 to make the puncture units 40 corresponding to the at least two switching parts 51 move synchronously.

Providing a linkage part 52 that connects at least two switching parts 51 is helpful to achieve synchronous control of different puncture units 40 .

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-11, and 13-16, the puncture driving unit 50 includes a limiting portion 53 and/or a guide portion 54. The limiting part 53 is configured to limit the movement range of the first movable part 5111 and/or the second movable part 5112. The guide portion 54 is configured to guide the movement of the first movable portion 5111 and/or the second movable portion 5112 .

The puncture driving unit 50 includes a limiting part 53 and/or a guide part 54, which is conducive to preventing excessive movement of the puncture unit 40 by limiting the movement range of the first movable part 5111 and/or the second movable part 5112, so that the puncture unit 40 can be in the first position. More accurate and faster switching between the puncture working state and the second puncture working state.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-11, and 13-16, the limiting portion 53 is configured to limit the movement range of the linkage portion 52 to limit the first movable portion. 5111 and/or the movement range of the second movable part 5112; and/or the guide part 54 is configured to guide the movement of the linkage part 52 to guide the movement of the first movable part 5111 and/or the second movable part 5112.

The limiting part 53 limits the movement range of the first movable part 5111 and/or the second movable part 5112 by limiting the movement range of the linkage part 52, which is conducive to achieving synchronous limitation of the puncture unit 40 that is linked through the linkage part 52, and can Reduce the number of components or structures used for limiting.

The guide part 54 is configured to guide the movement of the linkage part 52 to guide the movement of the first movable part 5111 and/or the second movable part 5112, which is conducive to achieving synchronous guidance of the puncture unit 40 that is linked through the linkage part 52, and can Reduce the number of components or structures used for guidance.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the limiting portion 53 includes one or more limiting structures, and at least one limiting structure includes a limiting structure. Groove 53A and stop surface 53B. The limiting surface 53B is movably located in the limiting groove 53A and has an abutting state with the limiting groove 53A. One of the limiting groove 53A and the limiting surface 53B is relative to the first movable part 5111 and the second movable part 5112. One is fixed, and the other is fixed relative to the other one of the first movable part 5111 and the second movable part 5112.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, Figures 9-11, and Figures 13-16, the guide portion 54 includes one or more guide structures, and at least one guide structure includes a guide groove 54A and a guide structure. The surface 54B and the guide surface 54B are in sliding fit with the guide groove 54A. One of the guide groove 54A and the guide surface 54B is fixed relative to the cartridge body 11 , and the other is fixed relative to the first movable part 5111 or the second movable part 5112 .

At least one limiting structure of the limiting portion 53 is configured to include a limiting groove 53A and a limiting surface 53B. The structure is simple and the movable range of the movable component to be controlled by the limiting portion 53 is accurately defined.

At least one guide structure of the guide portion 54 is configured to include a guide groove 54A and a guide surface 54B. The structure is simple and facilitates accurate guidance of the movement direction of the movable component to be guided by the guide portion 54 .

As shown in FIGS. 13 and 16 , the limiting surface 53B is provided on the limiting protrusion 531 .

As shown in Figures 4-6, 9-11, and 13-16, the puncture driving unit 50 includes a plurality of guide structures, and each guide structure includes a guide groove 54A and a corresponding guide surface 54B. The guide groove 54A is provided on the push-pull rod 521 , and the guide surface 54B is a partial surface of the support column 22 or a guide pin 541 provided on the support column 22 .

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-12, and 14-15, the puncture driving unit 50 further includes a positioning portion 55. The positioning part 55 has a positioning state that keeps the puncture unit 40 in the first puncture working state and/or the second puncture working state and an avoidance state that prevents interference with the switching of the puncture unit 40 working position. The positioning part 55 is movably relative to the cartridge body 11 Set to toggle between avoidance and positioning states.

The positioning part 55 can, for example, lock or unlock the position of at least one of the first movable part 5111, the second movable part 5112, the linkage part 52, and the sampling needle installation part 42 of the puncture unit 40 to achieve positioning and avoidance in its positioning state. Switch between states. For example, in the embodiment shown in FIGS. 1 to 19 , the positioning part 55 switches between its positioning state and the avoidance state by locking and unlocking the position of the second movable part 5112 .

By providing the positioning part 55, there is no need for the switching part 51 to continuously apply a driving force to the second movable part 5112 so that the second movable part 5112 can be stably maintained at the required position, thereby making the puncture device 40 stably in the second puncture working state, which is conducive to preventing When the reagent cartridge 30 is replaced, the reagent cartridge 30 interferes with the puncture needle 41 of the puncture device 40 .

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-12, and 14-15, the positioning portion 55 drives and cooperates with the reagent box 30, so as to be driven by the reagent box 30 in the avoidance state. and positioning status.

For example, when the reagent cartridge 30 is placed in the cartridge accommodating space 20A, the positioning part 55 is in the avoidance state, and when the reagent cartridge 30 is taken out from the reagent cartridge accommodating space 20A, the positioning part 55 is in the positioning state.

The reagent box 30 drives the positioning part 55 to switch between the avoidance state and the positioning state. There is no need to perform special operations on the positioning part 55 and the operation steps are simplified, so that the positioning part 55 can accurately move in and out of the reagent box accommodation space 20A as the reagent box 30 enters and exits the reagent box accommodation space 20A. In its required working condition.

In the reagent storage device 1 of some embodiments, as shown in Figure 12, the positioning part 55 includes a slider 551 and a slider reset mechanism 552. The slider 551 is movably installed in the cartridge body 11 relative to the cartridge body 11 and includes The positioning surface 5511D and the slider 551 are driven and matched with the reagent box 30. In the avoidance state of the positioning part 55, the slider 551 is in the avoidance position where the positioning surface 5511D is separated from the second movable part 5112, and the slider reset mechanism 552 is in the accumulating state. In the positioning state of the positioning part 55, the slider 551 is in a positioning position where the positioning surface 5511D is in contact with the second movable part 5112, and the slider reset mechanism 552 is in a release state.

In the embodiment shown in FIGS. 1 to 19 , the slider return mechanism 552 includes a spring located inside the slider 551 and with both ends pressing against the slider 511 and the support column 22 respectively.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the first movable part 5111 includes a first translation component 51111, and the first translation component 51111 is relative to the cartridge body 11 is disposed reciprocally movably along the first direction It includes a second translation component 51121, which is fixedly arranged relative to the sampling needle 41 and reciprocally movable along the second direction Z relative to the cartridge body 11. The second translation component 51121 is provided with a drive surface corresponding to the driving surface 51111A. The mating surface 51121A is inclined along the first direction X toward the second direction Z. By changing the position of the first translation component 51111 in the first direction The position of component 51121 along the second direction Z.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the puncture driving unit 50 includes a linkage part 52, and the linkage part 52 is drivingly connected to at least two switching parts 51 Or drive cooperation to make the puncture units 40 corresponding to at least two switching parts 51 move synchronously. The linkage part 52 includes a push-pull rod 521 extending along the first direction 51121 includes a pressure plate arranged along the second direction Z, and a mating surface 51121A is provided at an end of the pressure plate close to the first translation component 51111.

Wherein, the driving surface 51111A may include a curved surface and/or a flat surface, and the mating surface 51121A may include a curved surface and/or a flat surface. The driving surface 51111A and the mating surface 51121A are, for example, a flat surface, a curved surface, a combination of a flat surface and a flat surface, or a combination of a flat surface and a curved surface. Preferably, the driving surface 51111A and the mating surface 51121A are both arc surfaces mating with each other or both are flat surfaces mating with each other. The number of driving surfaces 51111A and mating surfaces 51121A can be set according to driving requirements.

For example, as shown in Figures 4-6, 9-11, and 13-16, the first translation component 51111 includes a protruding portion provided on the linkage portion 52 (such as the push-pull rod 521), and the driving surface 51111A includes a follower of the protruding portion. The linkage part 52 (such as the push-pull rod 521) is a curved surface that protrudes toward the second translation component 51121 (such as the pressure plate), such as an arc surface. Correspondingly, the mating surface 51121A includes a surface provided on the second translation component 51121 (such as the pressure plate). The end portion toward the side of the linkage portion 52 (such as the push-pull rod 521) is a convex curved surface, such as an arc-shaped surface, and toward the side away from the linkage portion 52 (such as the push-pull rod 521).

As the linkage part 52 (such as the push-pull rod 521) translates along the first direction When mated, the first translation component 51111 is in its first driving working position. At this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 enters the reagent storage space 30A. If the reagent box 30 is installed in the reagent box accommodation space 20A, then the The sample needle hole 41B is connected to the reagent storage space 30A of the kit 30, and the required substance can be introduced into the reagent storage space 30A through the sample needle 41 or drawn out from the reagent storage space to the end of the sample needle 41 away from the puncture end 41C. substance.

As the linkage part 52 (such as the push-pull rod 521) translates along the first direction During the convex-concave fit, the first translation component 51111 is in its second driving position. At this time, the piercing end 41C of the sampling needle 41 of the puncture unit 40 leaves the reagent kit accommodating space 20A. If the reagent kit 30 is installed in the reagent kit accommodating space 20A, Then the sampling needle needle hole 41B is disconnected from the reagent storage space 30A of the reagent box 30. At this time, the required substance cannot be introduced into the reagent storage space 30A through the sampling needle 41 or can be moved away from the reagent storage space toward the sampling needle 41. One end of the puncture end 41C draws out the substance.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the puncture driving unit 50 includes a limiting portion 53, and the limiting portion 53 is configured as a limiting linkage portion 52 to limit the movement range of the first movable part 5111. The limiting part 53 includes one or more limiting structures. At least one limiting structure includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably It is located in the limiting groove 53A and has an abutting state with the limiting groove 53A. One of the limiting groove 53A and the limiting surface 53B is provided on the second movable part 5112, and the other is provided on the push-pull rod 521.

The limiting groove 53A and the limiting surface 53B of at least one limiting structure of the limiting part 53 are arranged on the second movable part 5112 and the push-pull rod 521 respectively, which is conducive to limiting the movement range of the push-pull rod 521 while accurately determining the passage of the push-pull rod 521 . The movable range of each movable component of the switching part 51 linked by the pull rod 521 and the movable range of the puncture unit 40 driven by the puncture unit 40 are conducive to synchronously driving the puncture unit 40 driven by the push-pull rod 521 in the first puncture working state and the second puncture working state. Quickly and accurately switch between the two puncture working states.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 9-11, and 13-16, the puncture driving unit 50 includes a guide portion 54 configured to respond to the movement of the linkage portion 52 The guide is used to guide the movement of the first movable part 5111. The guide part 54 includes one or more guide structures. At least one guide structure includes a guide groove 54A and a guide surface 54B. One of the guide groove 54A and the guide surface 54B is relative to the cartridge body. 11 is fixed, and the other one is arranged on the push-pull rod 521.

The guide groove 54A and the guide surface 54B of at least one guide structure of the guide part 54 are respectively fixed and arranged on the push-pull rod 521 relative to the warehouse body 11, which is conducive to accurately guiding the movement direction of the push-pull rod 521 and connecting with the push-pull rod 521. The movement of the first movable component 5111 of the movable switching part 51 is guided, thereby facilitating the synchronous driving of the puncture unit 40 driven by the push-pull rod 521 to quickly and accurately switch between the first puncture working state and the second puncture working state.

In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and 32-37, the first movable part 5111 includes a first rotating component 51112, and the first rotating component 51112 is rotatably arranged relative to the cartridge body 11 ; The second movable part 5112 includes a second rotating part 51122. The second rotating part 51122 is rotatably arranged relative to the cartridge body 11 and is drivingly connected or driven with the first rotating part 51112. The second rotating part 51122 drives the puncture unit 40 in Switching between the first puncture working state and the second puncture working state.

The first movable part 5111 includes a first rotating part 51112, and the second movable part 5112 includes a second rotating part 51122, which facilitates the switching part 51 to realize its function through the rotating parts, requires a smaller operating range, and helps reduce the operating space.

In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and 32-37, the first rotating component 51112 is a rotating shaft; the second rotating component 51122 includes a cam disposed on the rotating shaft, and the cam and puncture Unit 40 is a press fit.

In the reagent storage device 1 of some embodiments, as shown in Figures 23-30 and 32-37, the puncture drive unit 50 also includes a movable connection part 58, the movable connection part 58 is connected to the cam and the puncture unit 40 respectively, and is configured In order to transmit the motion of the cam to the puncture unit 40 so that the rotation of the cam drives the puncture unit 40 to move.

Through the movable connection part 58, the synchronous movement of the cam 40 and the puncture unit 40 can be effectively ensured to prevent the puncture unit 40 from being stuck in close contact with the cam 40, thereby ensuring the stability and stability of the driving of the puncture unit 40 by the switching part 51. The accuracy facilitates the puncture unit 40 to switch working states promptly and accurately.

In the reagent storage device 1 of some embodiments, as shown in FIGS. 29-30 , the movable connection part 58 includes a movable element 581 , a first pin 582 and a second pin 583 . The first pin 582 is provided on the end surface of the cam. The second pins 583 and the first pins 582 are arranged on the puncture unit 40 in parallel and spaced apart. The movable element 581 has an arc-shaped groove 581A. The movable element 581 is mounted on the cam and puncture unit 40 through a first pin 582 and a second pin 583 that cooperate with the arc-shaped groove 581A. The groove 581A is a sliding fit.

The movable connection part 58 includes a movable element 581, a first pin 582 and a second pin 583, so that the movable connection part 58 has a simple structure and can reliably perform the function of following the puncture unit 40 with the cam.

In the reagent storage device 1 of some embodiments, as shown in Figures 23-24, Figures 26-29, and Figures 32-37, the puncture driving unit 50 includes a linkage part 52, and the linkage part 52 is drivingly connected to at least two switching parts 51 Or drive the matched first movable part 5111 and at least two switching parts 51 to cause the puncture units 40 corresponding to the at least two switching parts 51 to move synchronously. The linkage part 52 includes, for example, at least one of a belt transmission mechanism 522 , a chain transmission mechanism, a gear transmission mechanism, a gear and rack transmission mechanism or a link mechanism connected between the first rotating components 51112 of at least two switching parts 51 .

In the embodiment shown in FIGS. 20 to 37 , the linkage part 52 includes a belt transmission mechanism 522 connected between the rotation axes of the two puncture manipulation units corresponding to the same reagent kit accommodating space 20A. The belt transmission mechanism 522 includes pulleys respectively connected to two rotating shafts and a conveyor belt installed on the two pulleys. The conveyor belt can be of many types, such as a V-belt, a flat belt, a synchronous belt or a poly-ribbed belt, etc. The pulleys and conveyor belts are matched.

In the embodiment shown in Figures 20 to 37, the first rotating element and the corresponding second rotating element are coaxially fixedly connected, such as the cam being directly fixedly connected to the rotating shaft. In an embodiment not shown, the rotation axes of the first rotating element and the corresponding second rotating element can be set parallel or at an angle through an appropriate transmission mechanism such as a gear transmission mechanism. For example, the rotation axis and the cam can be It is driven and connected through a transmission device to drive the cam to rotate through the rotating shaft.

In addition, in an embodiment not shown in the figures, one of the first movable part 5111 and the second movable part 5112 may be a translation component and the other may be a rotation component. Translational components and rotating components can be converted through appropriate transmission mechanisms, such as gear and pinion mechanisms, cam ejector mechanisms, linkage mechanisms, etc.

In the reagent storage device 1 of some embodiments, the puncture driving unit 50 further includes an actuating part 56 , and the actuating part 56 is drivingly connected or drivingly matched with the first movable part 5111 .

In the embodiment shown in FIGS. 1 to 19 , the actuating part 56 includes a handle 561 , which is drivingly connected or matched with the first movable part 5111 . The handle 561 is disposed on a portion of the warehouse 11 where the door 12 is provided. side.

In the embodiment shown in FIGS. 20 to 37 , the actuating part 56 includes a rotating handle 562 , which is drivingly connected or in driving cooperation with the first movable part 5111 (rotating shaft). The rotating handle 562 is provided on the barrel body 11 The side where the warehouse door 12 is provided.

In an embodiment not shown, an actuator may also be provided, and the actuator is drivingly connected or drivingly matched with the first movable part 5111 . The actuator may replace the pull handle 561 or the rotary handle 562. The actuator may include, for example, an oil cylinder, a cylinder, a linear motor, a rotary motor, and other actuators. If it is necessary to convert the direction, speed, or force of the output of the actuator, a linkage part or a switching part can also be installed between the actuator and the linkage part. Appropriate transmission mechanisms are set up between them, such as the conversion of rotational motion and linear motion through gear and gear mechanisms, cam mechanisms or screw nut mechanisms, etc., and the conversion of speed or force through gear pairs, etc.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-6, 8-10, 14, 23-24, 26-29, 32, and 34-37, the switching part 51 includes Sample needle driving mechanism 511 and sample adding needle reset mechanism 512. One of the sampling needle driving mechanism 511 and the sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from the first puncture working state to the second puncture working state; The other one of the needle return mechanisms 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the second puncture operation state to the first puncture operation state.

The simultaneous provision of the sampling needle driving mechanism 511 and the sampling needle reset mechanism 512 facilitates the puncture unit 40 to quickly and accurately switch between the first puncture working state and the second puncture working state, thereby ensuring that the sampling needle is in the corresponding puncture working state. 41 is accurately connected or disconnected from the corresponding reagent storage space 30A.

In the embodiment shown in FIGS. 1 to 19 , the sampling needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the second puncture operation state to the first puncture operation state. In the embodiment shown in Figures 20 to 37, the sampling needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the second puncture operation state to the first puncture operation state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state.

In the reagent storage device 1 of some embodiments, as shown in Figures 4-10, 14, 23-30, and 31-37, the sampling needle reset mechanism 512 includes at least one spring 5121; the spring 5121 is located at and/or Connected between the puncture unit 40 and the kit storage unit 20; or the spring 5121 is located and/or connected between the cartridge body 11.

The sampling needle reset mechanism 512 includes at least one spring 5121 to facilitate automatic reset of the puncture unit 40 without special operations.

The type of spring is not limited here, as long as it can achieve the corresponding reset function, for example, it can be a coil spring, and can be set as a tension spring or a compression spring according to the installation position, or it can also be a gas spring or a torsion spring, etc.

In an embodiment that is not shown in the figures, the sampling needle resetting mechanism 512 may include, for example, an electromagnetic driving mechanism, a pneumatic mechanism, a hydraulic mechanism, or the like.

In the reagent storage device 1 of some embodiments, the reagent storage device 1 includes multiple reagent cartridge storage units 20, and/or the reagent cartridge storage unit 20 includes multiple reagent cartridge storage spaces 20A.

The reagent storage device 1 includes multiple reagent box storage units 20 , and the reagent box storage unit 20 includes multiple reagent box storage spaces 20A, which is beneficial to the simultaneous management and operation of multiple reagent boxes, and is beneficial to broadening the functions of the reagent storage device 1 .

In the reagent storage device 1 of some embodiments, the reagent storage device 1 further includes a heat preservation unit 60 , and the heat preservation unit 60 is configured to regulate the temperature of the reagent compartment 10 .

Due to the provision of the heat preservation unit 60, the reagents can be stored at a required temperature, thus ensuring the quality of the reagents.

In the reagent storage device 1 of some embodiments, as shown in Figures 2, 4-8, 21, 23, and 26-28, the heat preservation unit 60 includes a refrigerant circulation system 61.

The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615 that are connected in sequence through a refrigerant pipeline 611. In order to improve the heat exchange capabilities of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are also provided respectively. A four-way valve for switching the flow direction of the refrigerant can also be provided, so that the refrigerant circulation system 61 has both cooling and heating functions, so as to facilitate the internal accommodation space of the reagent bin 10 of the reagent storage device 1 to maintain a temperature lower than the environment or temperature above ambient.

As shown in Figure 1, Figure 3-6, Figure 8-10, Figure 14, Figure 19-20, Figure 22-29, Figure 32, and Figure 34-35, in the reagent storage device 1 of some embodiments, the reagent storage The device 1 includes a reagent box 30. The reagent box 30 includes a reagent storage space 30A. The reagent box storage space 20A of the reagent storage device 1 is used to place the reagent box 30; in the first puncture working state of the puncture unit 40, the sample needle hole is 41B is connected to the reagent storage space 30A of the reagent kit 30 placed in the reagent kit accommodation space 20A. In the second puncture working state of the puncture unit 40, the sampling needle needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30 placed in the reagent kit accommodation space 20A. The 30A reagent storage space is disconnected.

In the reagent storage device 1 of some embodiments, as shown in Figures 3-4, 6, 9, 14, 19, 22, 25-26, and 34, the reagent kit 30 has a sample needle The puncture end 41C of the 41 corresponds to the weak portion 301. In the first puncture working state of the puncture unit 40, the puncture end 41C of the sample adding needle 41 enters the reagent storage space 30A through the weak portion 301 to realize the adding of the sample needle 41. The pinhole 41B communicates with the reagent storage space 30A of the reagent kit 30 .

In order for the sample adding needle 41 to easily penetrate into the reagent kit body 31 to communicate with the reagent storage space 30A, a weak portion 301 that is easy for the reagent needle to pierce can be provided at the position where the reagent needle 31 and the reagent needle fit together. The weak part 301 may be, for example, a part that is thinner than the wall of the kit body 31 except the weak part 301 , or may be a part made of a different material than the wall of the kit body 31 except the weak part 301 . The part 301 can be easily replaced to realize the reuse of the reagent kit 30. For example, an opening and a cover closing the opening are provided on the part of the reagent kit body 31 corresponding to the reagent needle. The weak part 301 can be the cover itself or part of the covering and so on. The covering may be, for example, a film or a cover.

As shown in Figures 1, 3-6, and 7, in some embodiments of the reagent storage device 1, the reagent storage device 1 also includes a bottom plate 70. The bottom plate 70 is located in the reagent bin 10 and installed on the bottom wall of the bin body 11. On the bottom plate 70 , the reagent kit storage unit 20 and/or the puncture unit 40 are installed.

In the embodiment shown in FIGS. 1 to 19 , the components of the reagent storage device 1 located inside the reagent compartment 10 , such as the reagent cartridge storage unit 20 , the puncture unit 40 and the puncture drive unit 50 are all installed on the bottom plate 70 .

Different from the embodiment shown in FIGS. 1 to 19 , in the embodiment shown in FIGS. 20 to 37 , the components of the reagent storage device 1 located inside the reagent compartment 10 , such as the reagent box storage unit 20 , the puncture unit 40 and The puncture driving units 50 are installed on the bottom wall of the chamber body 11 of the reagent chamber 10 without providing a bottom plate.

The bottom plate 70 is provided in the reagent compartment 10, so that the partial structure of the reagent storage device 1 can be assembled and integrated into the internal accommodation space of the reagent compartment 10, thereby facilitating quick disassembly, assembly and maintenance.

As shown in Figure 38, an embodiment of the present disclosure also provides a reagent operating system, including the reagent storage device 1 of the previous embodiment of the present disclosure. The reagent operating system further includes at least one of a reagent receiving part 2, a cleaning liquid delivery part 3 and a gas communication part 4. The reagent receiving part 2 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40 . The cleaning liquid delivery part 3 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40 . The gas communication part 4 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40 .

The reagent operating system of the embodiment of the present disclosure is coupled with the sampling needle 41 of the puncture unit 40 of the reagent storage device 1 through the reagent receiving part 2 and/or the cleaning liquid transport part 3 and/or the gas communication part 4, so that reagent sampling and output can be realized And/or the function of transporting cleaning liquid to the reagent storage space 30A to clean the sampling needle 41 and/or connecting the reagent storage space 30A with the outside air so that the reagent or cleaning liquid can smoothly enter or flow out of the reagent storage space 30A. The reagent receiving part 2 is provided so that the reagents in the reagent box 30 can be introduced into the reagent receiving part 2 to realize reagent transfer. The cleaning liquid transport part 3 is provided to introduce the cleaning liquid into the reagent box 30 to clean the sampling needle 41 that has been in contact with the reagent, thereby realizing cleaning of the sampling needle 41 . Providing the gas communication part 4 can introduce gas into the reagent storage space 30A of the reagent box 30, thereby facilitating the control of the pressure of the reagent storage space 30A and the control of the reagent outflow speed.

In some embodiments of the reagent operating system, the reagent operating system includes a reagent receiving part 2 and a cleaning liquid delivery part 3. The reagent receiving part 2 and the cleaning liquid delivery part 3 are respectively connected to the internal channels of the sampling needles 41 of different puncture units 40. 41A has a connected state; and/or the reagent operating system includes a cleaning liquid delivery part 3 and a gas communication part 4. The cleaning liquid delivery part 3 and the gas communication part 4 are connected to the internal channel 41A of the sampling needle 41 of the same puncture unit 40 at different time periods. Has connectivity status.

In the reagent operating system of some embodiments, the reagent operating system includes a reagent receiving part 2 and a cleaning liquid delivery part 3 . Among them, the puncture end 41C of the sampling needle 41 of the puncture unit 40 in the reagent receiving part 2 is located outside or below the bottom of the corresponding reagent box accommodation space 20A; the puncture unit 40 in the cleaning fluid delivery part 3 is in communication. The puncture end 41C of the sample adding needle 41 is located outside or above the top of the corresponding kit accommodation space 20A.

The above arrangement is conducive to drawing out the reagent. The sampling needle 41 for drawing out the reagent can be pierced into the reagent box 30 to a shallow depth so that the reagents in the corresponding reagent storage space 30A can be emptied, so that less cleaning fluid can be used to clean the needle for drawing out the reagent. 41, and the sampling needle 41 used to introduce the cleaning solution will not come into contact with the reagent and will not be contaminated by the reagent.

In some embodiments of the reagent operating system, the reagent receiving part 2 is connected to the sampling needle 41 of at least one puncture unit 40 through a connecting tube with a flexible tube section or a telescopic tube section; and/or the cleaning liquid delivery part 3 is connected with at least one puncture unit The sampling needle 41 of the unit 40 is connected through a connecting tube with a flexible tube section or a telescopic tube section; and/or the gas communication part 4 is connected to the sampling needle 41 of at least one puncture unit 40 through a connecting tube with a flexible tube section or a telescopic tube section. .

One end of the sampling needle 41 away from the puncture needle hole 41B can be connected to one end of a connecting tube including a flexible tube section or a telescopic tube section, and the other end of the connecting tube is connected to the perforation on the cartridge body 11 or passes through the perforation on the cartridge body 11 , the reagent receiving part 2 or the cleaning liquid delivery part 3 or the gas communication part 4 located outside the reagent storage device 1 can be connected to the perforation or the other end of the connecting tube, thereby connecting to the sampling needle 41, because the connecting tube includes a flexible tube section The flexibility or the telescopic performance of the connecting tube including the telescopic tube section, the position change of the sampling needle 41 caused by the switching of the working position of the puncture unit 40 does not affect the connection between the reagent receiving part 2 or the cleaning liquid delivery part 3 or the gas communication part 4 and the connecting tube The second end is connected or does not affect the connection with the perforated hole on the warehouse body 11.

In the reagent operating system of some embodiments, the reagent receiving part 2 is connected to the sampling needle 41 of at least one puncture unit 40 through a connecting pipe that passes through the cartridge body 11 and is sealed between the cartridge body 11; and/or the cleaning liquid is transported Part 3 is connected to the sampling needle 41 of at least one puncture unit 40 through a connecting pipe that passes through the cartridge body 11 and is sealed with the cartridge body 11; and/or the gas communication part 4 is connected to the sampling needle 41 of at least one puncture unit 40. It is connected through a connecting pipe that passes through the warehouse body 11 and is sealed between the warehouse bodies 11 .

Since the connecting tube connecting the reagent receiving part 2 and/or the cleaning liquid delivery part 3 and/or the gas connecting part 4 and the sampling needle 41 is sealed with the chamber body 11, external air can be better prevented from entering the reagent chamber 10, thereby facilitating This prevents air from entering the internal accommodation space of the reagent compartment 10 through the gap between the connecting pipe and the compartment body 11 to form condensation water and then carry dust and impurities and fall into the reagent box to contaminate the reagents.

The embodiments of the present disclosure will be described in detail below with reference to FIGS. 1 to 38 .

In the description of the following embodiments of the present disclosure: "front" refers to the side where the warehouse door is located, corresponding to the X direction in Figures 1 and 20, that is, corresponding to the aforementioned first direction, and "rear" refers to the side opposite to the "front" One side; “upper” and “lower” refer to the upper and lower directions of the reagent storage device 1 when it is normally placed, and “upper” corresponds to the Z direction in Figures 1 and 20, that is, corresponds to the aforementioned second direction, and “upper” and "Down" is also expressed as "top" and "bottom" respectively in the following description; "left" and "right" refer to the left and right directions when viewed from "front" to "back", and "right" corresponds to the left and right directions in Figure 1 The Y direction can also be called the third direction.

1 to 19 illustrate a reagent storage device 1 according to an embodiment of the present disclosure. In the embodiment shown in FIGS. 1 to 19 , the reagent storage device 1 includes a reagent bin 10 , a reagent box storage unit 20 , a reagent box 30 , a puncture unit 40 , a puncture drive unit 50 , a warming unit 60 and a bottom plate 70 .

The reagent compartment 10 includes a compartment body 11 and a compartment door 12 for closing the compartment body 11 . The bin body 11 is a cube with an opening facing the front side of the bin body 11 . An internal accommodation space of the reagent compartment 1 is formed in the compartment body 11. After the compartment door 12 is closed, the internal accommodation space is sealed. The warehouse door 12 is hinged with the front end of the right side wall of the warehouse body 11 .

The reagent kit storage unit 20, the reagent kit 30, the puncture unit 40, the puncture drive unit 50, the warming unit 60 and the bottom plate 70 are all located in the internal accommodation space. The bottom plate 70 is installed on the bottom wall of the warehouse 11 , and the reagent box storage unit 20 , the reagent box 30 , the puncture unit 40 , the puncture drive unit 50 , and the heat preservation unit 60 are all installed on the bottom plate 70 .

The reagent storage device 1 includes two reagent cartridge storage units 20 arranged side by side. Each reagent kit storage unit 20 includes a reagent kit storage space 20A, and the reagent kit storage space 20A is configured to place the reagent kit 30 having a reagent storage space 30A.

Each kit storage unit 20 includes two parallel-spaced upper and lower square kit protective plates as the kit protective parts 21 and four connecting rods 22 . The reagent kit protective plate has a puncture end escape opening 21A for avoiding the puncture end 41C of the sampling needle 41 . A connecting rod 22 is respectively provided at the four corners of the upper and lower reagent kit protective plates, and each connecting rod 22 is fixedly connected to the upper and lower reagent kit protective plates. Each connecting rod 22 passes through the upper and lower kit protective plates. The upper and lower ends of the connecting rod 22 are respectively located above and below the upper and lower kit protective plates. The bottom end of the connecting rod 22 is fixedly connected to the bottom plate 70 . The bottom end of the connecting rod 22 is fixedly connected to the bottom plate 70 by, for example, welding or threading or connecting through a connector. The part of the connecting rod 22 located between the two reagent kit protective plates is a square rod section with a square cross-section, and the parts of the connecting rod 22 located above and below the two reagent kit protective plates are circular rod sections respectively. The space defined by the two upper and lower kit protective plates and four connecting rods 22 is the kit accommodation space 20A. In an embodiment not shown, the cross-sectional shape of the connecting rod 22 may be square or circular from top to bottom.

The reagent kit 30 includes a plurality of reagent storage spaces 30A. The reagent kit 30 includes a plurality of reagent kit bodies 31, and each of the plurality of reagent kit bodies 31 includes a single reagent storage space 30A.

As shown in FIG. 19 , the reagent kit 30 also includes a mounting frame 32 and a cover plate 33 . The installation frame 32 includes a square frame body and a plurality of partitions. The plurality of partitions divide the space in the frame body into a plurality of independent areas corresponding to the plurality of kit bodies 31. The top of each kit body 31 is open. , is installed on the lower part of the installation frame 32, and is sealingly connected with the partition plate of the corresponding independent area and the top end of the frame body. The cover plate 33 covers the installation frame 32, and is sealingly connected with the frame body and the top end of the partition plate. The cover 33 is provided with a plurality of weak portions 301 corresponding to each independent area and the corresponding kit body 31 . Each kit body 31 has a hole in the bottom wall, and each hole is provided with a plug 34 that is inserted into the hole. The plug 34 is provided with a weak portion 301 . After the reagent kit 30 is installed in the reagent kit accommodating space 20A, each weak portion 301 faces the corresponding sampling needle 41 .

The reagent storage device 1 includes four puncture units 40, and each reagent box storage unit 20 is provided with two puncture units 40 correspondingly. Among the two puncture units 40 corresponding to the same kit accommodation space 20A, the puncture end 41C of the sampling needle 41 of one puncture unit 40 is located below the corresponding kit accommodation space 20A, and the puncture end 41C of the sampling needle 41 of the other puncture unit 40 is located below the corresponding kit accommodation space 20A. The puncture end 41C of the sample needle 41 is located above the corresponding kit accommodation space 20A.

The puncture unit 40 includes a sampling needle mounting part 42 and a plurality of sampling needles 41 fixed on the sampling needle mounting part 42 . The sample needle mounting part 42 is a mounting plate.

The sampling needle 41 has an internal channel 41A and a puncture end 41C. The puncture end 41C is provided with a sampling needle hole 41B that communicates with the internal channel 41A.

The puncture unit 40 is movably disposed relative to the kit storage unit 20 and has a first puncture working state and a second puncturing working state. When the reagent kit 30 is placed in the reagent kit accommodation space 20A, in the first puncture working state, the sample adding needle needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30, and in the second puncture working state, the sample adding needle The pinhole 41B is disconnected from the reagent storage space 30A of the reagent cartridge 30 .

Among them, the puncture end 41C of the sampling needle 41 of the puncture unit 40 located below the kit accommodation space 20A is located below the corresponding kit accommodation space 20A. The puncture unit 40 located below is used to discharge the reagents in the reagent kit 30 . The puncture end 41C of the sampling needle 41 of the puncture unit 40 located above the same reagent kit accommodation space 20A is located above the corresponding reagent kit accommodation space 20A. The upper puncture unit 40 is used to communicate with the gas when the lower puncture unit 40 exports the reagents of the kit 30 to smoothly export the reagents, and is also used to discharge the reagents after the lower puncture unit 40 exports the reagents of the kit 30 . The cleaning liquid is passed into the storage space 30A to clean the sampling needle 41 of the puncture unit 40 located below.

As shown in FIGS. 17 and 18 , the sampling needle 41 of the puncture unit 40 includes a sampling needle tube 411 and a sampling needle tip 412 . The internal channel 41A is located in the sample adding needle tube 411 . The sampling needle tip 412 is located at the puncture end 41C of the sampling needle 41 and is connected to one end of the sampling needle tube 411. The cross section of the sampling needle tip 412 gradually decreases from the sampling needle tube 411 to the side away from the sampling needle tube 411. Small cones. The sample adding needle hole 41B is located on the side wall of the sample adding needle tube 411 close to the sample adding needle tip 412 .

The sampling needle needle tube 411 includes a first sampling needle straight tube section 4111, a sampling needle curved tube section 4112, and a second sampling needle straight tube section 4113. The bending tube section 4112 of the sampling needle is a flexible tube section. The first straight pipe section 4111 of the sampling needle extends along the first direction X along the chamber wall surface of the chamber body 11 . The second sample adding needle straight tube section 4113 extends from one side of the chamber wall surface of the chamber body 11 toward the kit accommodating space 20A, that is, extends along the second direction Z. One end of the second sampling needle straight tube section 4113 is connected to one end of the first sampling needle straight tube section 4111 through a sampling needle curved tube section 4112, and the sampling needle tip 412 is connected to the other end of the second sampling needle straight tube section 4113. Each sample adding needle 41 is installed on the sample adding needle mounting part 42 through its fixed connection part 413. The fixed connection part 413 and the sampling needle mounting part 42 are, for example, threaded or interference-fitted.

The reagent storage device 1 includes two puncture drive units 50 . Each puncture driving unit 50 is provided corresponding to one reagent kit storage unit 20 and is drivingly connected to the two puncture units 40 corresponding to the corresponding reagent kit storage unit 20 .

Each puncture drive unit 50 includes a switching part 51 , a linkage part 52 , a limiting part 53 , a guide part 54 , a positioning part 55 and an actuating part 56 .

Each puncture driving unit 50 includes two switching parts 51 corresponding to the two puncture units 40 one-to-one. Each switching part 51 is drivingly connected or drivingly matched with the corresponding puncture unit 40, and is configured to drive the puncture unit 40 to switch between the first puncture operation state and the second puncture operation state. The two switching parts 51 are provided in conjunction with each other through the linkage part 52 to simultaneously drive the two puncture units 40 corresponding to the same kit accommodation space 20A, so that the two puncture units 40 can be synchronously switched from the first puncture operating state to the second puncture operating state. The puncture working state or the second puncture working state is synchronously switched to the first puncture working state.

In this embodiment, multiple sampling needles 41 of each puncture unit 42 are installed on the sampling needle mounting part 42, and the switching part 51 is drivingly connected or driven with the sampling needle mounting part 42 of the puncture unit 40 to drive multiple sampling needles. The sample adding needle 41 moves synchronously.

The switching part 51 includes a sampling needle driving mechanism 511 and a sampling needle reset mechanism 512 . The sampling needle driving mechanism 511 applies a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state. The sampling needle reset mechanism 512 applies a force to the puncture unit 40 to switch from the second puncture working state to the first puncturing working state.

The sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is drivingly connected or driven with the first movable part 5111 and the puncture unit 40. Referring to Figures 14 to 16, when the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first driving position. Puncturing working state, refer to Figures 4-6 and 8-11. When the first movable part 5111 is in its second driving working position, the puncturing unit 40 is in the second puncturing working state.

The first movable part 5111 of each sampling needle driving mechanism 511 includes four first translation parts 51111, and two first translation parts 51111 are provided on both the front and rear sides of the reagent cartridge storage unit 20. The two first translation parts 51111 on each side of the reagent kit storage unit 20 are spaced apart in the front and rear direction. Each first translation component 51111 is disposed so as to be reciprocally movable along the first direction The second direction Z is tilted.

The second movable part 5112 of each adding needle driving mechanism 511 includes two second translation parts 51121, and one second translation part 51121 is provided on the left and right sides of the reagent cartridge storage unit 20. Each second translation component 51121 is fixedly connected to the corresponding sampling needle mounting portion 42 and is thus fixedly arranged relative to the sampling needle 41 . Each second translation component 51121 is disposed so as to be reciprocally movable along the second direction Z relative to the cartridge body 11 . Each second translation component 51121 is provided with two mating surfaces 51121A corresponding to the two driving surfaces 51111A of the first translation component 51111 on the corresponding side. The mating surface 51121A is inclined along the first direction X toward the second direction Z. By changing the position of the first translation member 51111 in the first direction X, the mating position of the driving surface 51111A and the corresponding mating surface 51121A is changed to change the position of the second translation member 51121 along the second direction Z.

Each sampling needle reset mechanism 512 includes four springs 5121. The four springs 5121 are located at the four corners of the reagent kit storage unit 20. Each spring 5121 is sleeved on the connecting rod 22 at the corresponding corner. The connecting rod 22 The corresponding end of the spring 5121 passes through the sampling needle mounting part 42 and some rod segments extend out of the sampling needle mounting part 42 . The spring 5121 is sleeved on the rod segment outside the sampling needle mounting part 42 . One end of the spring 5121 is in contact with the corresponding sampling needle mounting part 42, and the other end is in contact with the spring seat 5122. The spring seat 5122 is fixed to the end of the connecting rod 22 through a threaded connector. Each spring 5121 is a compression spring, thereby exerting a force on the sampling needle mounting part 42 toward the reagent cartridge storage unit 20 side, and also exerting a force on the second translation member 51121 through the sampling needle mounting part 42 toward the push-pull rod 521 force, so that when the push-pull rod 521 is at the rear extreme position, each driving surface 51111A and the corresponding mating surface 51121A are in a convex-concave mating state, which is beneficial to the sampling needle mounting part 42 when the puncture unit 40 is in the first puncture working state. , the sampling needle installation part 42 and the sampling needle 421 thereon both reach the designated position, preventing the situation that the sampling needle 421 cannot effectively communicate with the corresponding reagent storage space 30A.

The linkage part 52 is drivingly connected or driven with the two switching parts 51 to make the puncture units 40 corresponding to the two switching parts 51 move synchronously. The linkage part 52 includes two push-pull rods 521 extending along the first direction X. Two push-pull rods 521 are respectively located on the left and right sides of the reagent kit storage unit 20 . Each first translation component 51111 of the two puncture units 40 is fixed on the push-pull rod 521 on the same side. The driving surface 51111A is provided on a side of the push-pull rod 521 close to the corresponding second translation component 51121. The second translation part 51121 includes a pressure plate, the pressure plate is arranged along the second direction Z, and the mating surface 51121A is provided at an end of the pressure plate close to the corresponding first translation part 51111.

The first translation component 51111 is a protruding portion provided on the push-pull rod 521, and the driving surface 51111A is an arc-shaped surface of the protruding portion protruding from the push-pull rod 521 toward the side of the pressure plate. Correspondingly, the mating surface 51121A includes a direction provided on the pressure plate. The end of one side of the push-pull rod 521 has an arc-shaped surface that protrudes toward the side away from the push-pull rod 521 .

As the push-pull rod 521 translates in the front-to-back direction, when the driving surface 51111A located on the push-pull rod 521 is located within the mating surface 51121A provided on the pressure plate, that is, when the two arc-shaped surfaces respectively serving as the driving surface 51111A and the mating surface 51121A fit together convexly and concavely , the first translation component 51111 is in its first driving working position (as shown in Figures 14-16). At this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 enters the reagent containing space 20A. If the reagent box containing space 20A When the reagent kit 30 is installed inside, the tip 412 of the sampling needle penetrates into the corresponding reagent kit body 31, and the needle hole 41B of the sampling needle is connected to the corresponding reagent storage space 30A of the reagent kit body 31, so that the sampling needle 41 can be used to The required substance is introduced into the reagent storage space 30A or the substance is extracted from the reagent storage space 20A to the end of the sampling needle 41 away from the puncture end 41C.

As the push-pull rod 521 translates in the front-rear direction, when the arc-shaped surface on the push-pull rod 521 leaves the arc-shaped surface of the pressure plate, that is, when the two arc-shaped surfaces release the convex-concave fit, the first translation component 51111 is in its second position. Drive the working position (shown in Figure 4-6, Figure 9-11, and Figure 12). At this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 leaves the reagent kit accommodation space 20A. If the reagent kit accommodation space 20A contains kit 30, the tip 412 of the sampling needle is separated from the corresponding kit body 31, and the needle hole 41B of the sampling needle is disconnected from the corresponding reagent storage space 30A of the kit body 31. At this time, the reagent cannot be supplied to the reagent through the sampling needle 41. The required substance is introduced into the storage space 30A or the substance is drawn out from the reagent storage space to the end of the sampling needle 41 away from the puncture end 41C.

The limiting part 53 is configured to limit the movement range of the first movable part 5111 and the second movable part 5112. In this embodiment, the limiting portion 53 limits the movement range of the first movable portion 5111 and the second movable portion 5112 by limiting the movement range of the push-pull rod 521 serving as the linkage portion 52 .

As shown in Figures 4-6, 9-11, and 13-16, the limiting portion 53 of each puncture drive unit 50 includes four limiting structures. Among the four limiting structures, they are grouped into two groups. The limiting structure is located on the upper and lower sides of a push-pull rod 521. Each limiting structure includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably located in the limiting groove 53A and is in contact with the limiting groove 53A. The limiting groove 53A is provided on the second movable part 5112. In this embodiment, it is provided on the pressure plate. The limiting surface 53B is provided on the push-pull rod 521 as the interlocking part 52 . Specifically, the push-pull rod 521 is provided with a limiting protrusion 531 facing the pressure plate, and the limiting surface 53B is a partial surface of the limiting protrusion 531 .

As shown in Figures 4-6, 9-11, and 13-16, a limiting protrusion 531 is provided on the upper and lower sides of each push-pull rod 521. The limiting protrusion 531 is hook-shaped and includes a main body connected to the push-pull rod 521 and a hook portion located on a side away from the push-pull rod 521 and protruding toward the first direction X. The surface of the hook portion faces the push-pull rod 521 It is inclined outward from the main body along the direction from the side close to the push-pull rod 521 to the side away from the push-pull rod 521 . The surface of the hook facing the push-pull rod 521 forms part of the stop surface 53B. The surface of the main body part opposite to the hook part forms another part of the limiting surface. A limiting groove 53A is provided on one side of the pressure plate corresponding to each limiting protrusion 531. The limiting groove 53A includes a first groove section close to the push-pull rod 521 and a groove section connected to the first groove section away from the push-pull rod. 521 side of the second groove section, the width of the second groove section along the first direction X is greater than the width of the first groove section along the first direction X, and the first groove section and the second groove section are connected by a step surface. The limiting protrusion 531 is located in the limiting groove 53A, and the limiting protrusion 531 has a movable margin in the limiting groove 53A along the first direction X.

When the push-pull rod 521 moves from the front side to the rear side, the hook portion is driven by the push-pull rod 521 toward the corner where the surface on one side of the push-pull rod 521 and the step surface on the rear side of the limiting groove 53A intersect with the first groove section and finally come into contact with each other. After contacting, the limiting structure 53 prevents the push-pull rod 521 from continuing to move backward, so that the backward movement of the first translation component 51111 is limited by limiting the push-pull rod 521 . In addition, the hook restricts the movement of the second translation member 51121 in a direction away from the push-pull rod, thereby also having a limiting effect on the upward movement of the second translation member 51121.

When the push-pull rod 521 moves from the rear side to the front side, the hook portion is driven by the push-pull rod 521 toward the surface on one side of the push-pull rod 521 and gradually moves away from the step surface of the limiting groove 53A, releasing the push of the second translation member 51121 away from the To limit the movement of the pull rod, the second translation member 51121 can move in the second direction Z away from the push-pull rod 521 driven by the push-pull rod 521 and the first translation member 51111 thereon. As the push-pull rod 521 continues to move forward, the surface of the main body of the limiting protrusion 531 on the side opposite to the hook portion abuts against the right side wall of the first groove section of the limiting groove 53A, abutting the rear limiting structure. 53 prevents the push-pull rod 521 from continuing to move to the right, thereby limiting the forward movement of the first translation component 51111 by limiting the push-pull rod 521.

As shown in Figures 4-6, 9-11, and 13-16, the guide portion 54 is configured to guide the movement of the first movable portion 5111 in the first direction X. In this embodiment, the guide portion 54 guides the movement of the first movable portion 5111 by guiding the movement of the push-pull rod 521 serving as the linkage portion 52 .

As shown in Figures 4-6, 9-11, and 13-16, the guide portion 54 includes a plurality of guide structures. Each guide structure includes a guide groove 54A and a corresponding guide surface 54B. The guide surface 54B and the corresponding guide groove 54A With sliding fit, the guide surface 54B is fixed relative to the warehouse body 11 , and the guide groove 54A is fixed relative to the first movable part 5111 . For example, in this embodiment, the guide groove 54A is provided on the push-pull rod 521 .

As shown in Figures 4-6, 9-11, and 13-16, each of the front and rear ends of each push-pull rod 521 of the puncture drive unit 50 is provided with two corresponding guide structures. Among the two guide structures corresponding to each end of each push-pull rod 521, the guide groove 54A of one of the guide structures is provided on the push-pull rod 521 and the groove direction is the second direction Z. The reagent kit extending along the second direction Z is stored. The support column 22 of the unit 20 passes through the guide groove 54A. The surface of the support column 22 along the third direction Y is slidably matched with the guide groove 54A, and has a movable margin along the first direction X in the guide groove 54A. Among the two guide structures at each end of each push-pull rod 521, the guide groove 54A of the other guide structure is on the push-pull rod 521 and the groove direction is the third direction Y, and the corresponding guide surface 54B is provided on the guide pin 541. The axial direction of the guide pin 541 is the third direction Y, is disposed in the corresponding guide groove 54A, slides with the guide groove 54A, and has a movable margin along the first direction X in the guide groove 54A.

In the embodiment shown in FIGS. 1 to 19 , the linkage part 52 is movably installed on the support column 22 through the guide pin 541 . In addition, the length and position of the guide groove 54A corresponding to the guide pin 541 should be set appropriately so that the front limit position and the rear limit position of the guide pin 541's relative movement in the guide groove 54A are exactly in line with the first translation component 51111 on the push-pull rod 521. The second driving working position corresponds to the first driving working position, so the guide pin 541 and the corresponding guide groove 54A can also play a role in limiting the movement of the first movable part 5111 along the first direction X. Similarly, the connecting rod 22 and the corresponding guide groove 54A can also play a role in limiting the movement of the first movable part 5111 along the first direction X by properly setting the length and position of the guide groove 54A.

As shown in Figures 4-6, 9-12, and 14-15, the positioning portion 55 has a positioning state to maintain the puncture unit 40 in the second puncture working state and an avoidance state to prevent interference with the puncture unit 40 switching working positions. The portion 55 is movably disposed relative to the bin body 11 to switch between the avoidance state and the positioning state.

The positioning part 55 realizes switching between its positioning state and avoidance state by locking and unlocking the position of the second movable part 5112. When the first movable part 5111 is in its second driving working position, the positioning part 55 is in a positioning state. When the first movable part 5111 switches between the first driving working position and the second driving working position, the positioning part 55 is in the avoidance state.

The positioning part 55 drives and cooperates with the reagent box 30 to switch between the avoidance state and the positioning state under the driving of the reagent box 30 . When the reagent cartridge 30 is placed in the reagent cartridge storage space 20A, the positioning portion 55 is in the avoidance state. When the reagent cartridge 30 is taken out from the reagent cartridge storage space 20A, the positioning portion 55 is in the positioning state.

As shown in FIG. 12 , the positioning part 55 includes a slider 551 and a slider reset mechanism 552 . The slider 551 is movably installed in the bin body 11 relative to the bin body 11 and includes a positioning surface 5511D. The slider 551 is driven and engaged with the reagent box 30. In the avoidance state of the positioning part 55, the slider 551 is in the avoidance position where the positioning surface 5511D is separated from the second movable part 5112. The slider reset mechanism 552 is in a force-accumulating state. In the positioning state of the positioning part 55, the slider 551 is in a positioning position where the positioning surface 5511D contacts the second movable part 5112, and the slider reset mechanism 552 is in a force-releasing state. In this embodiment, the positioning part 55 of each puncture drive unit 50 includes two positioning mechanisms. The two positioning mechanisms are respectively located at the rear of the left and right sides of the reagent box storage unit 20. Each positioning mechanism is installed on the corresponding side. on support column 22.

The structure of the positioning mechanism will be described below with reference to Figures 11 to 12 . As shown in FIGS. 11 and 12 , the positioning mechanism includes the aforementioned slider 551 , slider reset mechanism 552 and slider mounting pin 553 .

As shown in FIG. 12 , the slider 551 includes two first blocks 5511 arranged in parallel and spaced apart and a second block 5512 connected at right angles to the two first blocks 5511 . The slider 551 is movably installed on the support column 22 .

The rear section of the push-pull rod 521 is located in the interval between the two first blocks 5511, and the push-pull rod 521 is in sliding fit with the slider 551. Therefore, the push-pull rod 521 defines the position of the slider 551 in the second direction Z and the movement in the first direction X. Each first block 5511 of the slider 551 is also provided with a first slider groove 5511A and a second slider groove 5511B. The groove direction of the first slider groove 5511B is the second direction Z. The corresponding support column 22 penetrates into the first slider groove 5511B of the two first blocks 5511, is slidingly connected with the first slider groove 5511B, and has a movable margin along the first direction X on the first slider groove 5511B. . The slotting direction of the second slider groove 5511B is the third direction Y, and the two slider mounting pins 553 are respectively provided corresponding to the second slider grooves 5511B of the two first blocks 5511. The axial direction of the slider mounting pin 553 is the third direction Y. It is installed on the support column 22 and located in the second slider groove 5511B. The slider mounting pin 553 is in sliding fit with the second slider groove 5511B and moves along the first direction X. There is room for activity. Therefore, the slider 551 is movably installed on the support column 22 through the slider mounting pin 553 and the push-pull rod 521 .

In this embodiment, the front limit position and the rear limit position of the slider mounting pin 553 in the second slider groove 5511B determine the limit position of the slider 551 .

In the embodiment shown in FIGS. 1 to 19 , the slider reset mechanism 552 includes a spring located inside the slider 551 and with both ends pressing against the slider 511 and the support column 22 respectively. In this embodiment, a spring installation hole 5511C extending along the first direction X is provided in each first block 5511, and a spring is provided in the spring installation hole 5511C. The spring installation hole 5511C is connected with the first slider groove 5511A, so that one end of the spring is against the support column 22 to exert force on the support column 22 . In order to facilitate spring installation and spring elastic force adjustment, a threaded hole can be opened at the end of the spring mounting hole 5511C, and a screw matching the threaded hole can be set in the threaded hole. The screw offsets one end of the spring. When the adjusting screw is in the threaded hole position, the elastic force of the spring is adjusted accordingly.

The positioning surface 5511D is provided at one end of each first block 5511 away from the second block 5112. One end of the first block 5511 away from the second block 5512 includes a step surface facing the corresponding puncture unit 40 side, and the step surface forms a positioning surface 5511D.

The second block 5512 is opposite to the rear part of the reagent kit accommodating space 20A, and is located in the reagent kit accommodating space 20A when the slide reset mechanism 552 is in the force release state. When the kit 30 moves from front to back and is gradually pushed into the kit accommodating space 20A, it gradually approaches and comes into contact with the second block 5512. After contact, the second block 5512 gradually moves backward under the push of the kit 30. , when the second block 5512 moves backward, the positioning surface 5511D of the slider 551 moves backward and the overlapping portion with the second movable part 5112 in the first direction X gradually decreases until it separates and is in the avoidance position. The position is as shown in Figure 14. At this time, the slider return mechanism 552 is in a force-accumulating state. In the force-accumulating state, the slider return mechanism 552, such as a spring, receives the greatest force.

Before the reagent kit 30 is taken out from the reagent kit accommodating space 20A, the push-pull rod 521 needs to be pulled forward, so that the first translation component 51111 arranged on the push-pull rod 521 moves forward, and the two upper and lower second translation parts on the left side move forward. The translation component 51121 and the two upper and lower second translation components 51121 on the right side move upward and on both sides respectively, so that each puncture unit 40 is in the second puncture working state. When the test kit 30 is taken out from the kit accommodation space 20A, it gradually moves toward Move forward, due to the action of the spring of the positioning part 55, the second block 5512 and the slider 551 follow the reagent box 30 to move forward until they are limited by the slider installation pin 553 and the second slider groove 5511B, and the slider 551 does not move forward. As the reagent box 30 moves, the slider reset mechanism 552 of the positioning part 55 is in the force release state. In the force release state, the force of the slider return mechanism 552 such as the spring is minimal.

In the embodiment shown in FIGS. 1 to 19 , the actuating part 56 of each puncture drive unit 50 includes a handle 561 , the handle 561 is drivingly connected or driven with the first movable part 5111 of the switching part 51 , and the handle 561 is configured The side of the warehouse body 11 with the door 12 is located on the front side.

The handle 561 has a U-shaped structure, and the U-shaped structure includes two first handle bars arranged in parallel and spaced apart and a second handle bar connecting the two first handle bars. The two first handle rods extend in the up and down direction and are respectively arranged on the left and right sides of the kit accommodation space 20A. The free end of each first handle rod is fixedly connected to the front end of the push-pull rod 521 . The second handle bar extends in the left-right direction and is located above the kit accommodating space 20A. The U-shaped handle 56 can avoid the entrance and exit of the kit 30 at the front end of the kit accommodating space 20A.

The heat preservation unit 60 is configured to regulate the temperature of the reagent compartment 10 . The heat preservation unit 60 includes a refrigerant circulation system 61 . The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615 that are connected in sequence through a refrigerant pipeline 611. In order to improve the heat exchange capabilities of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are also provided respectively.

20 to 37 illustrate a reagent storage device 1 according to another embodiment of the present disclosure. Figures 20 to 37 show the reagent compartment 10, reagent box storage unit 20, reagent box 30, puncture unit 40 and insulation unit 60 of the reagent storage device 1 according to another embodiment of the present disclosure. 1 to 19 for the composition, structure and function of these parts. In the following, only the embodiments shown in FIGS. 20 and 37 will be compared with those shown in FIGS. 1 to 19 The differences between the embodiments shown are explained.

As shown in Figures 20 to 37, the reagent storage device 1 of this embodiment does not include a bottom plate. In addition, the structure of the puncture drive unit 50 is different from that of the reagent storage device 1 of the embodiment shown in Figures 1 to 19. In addition, a detection unit 80 is provided.

In this embodiment, each puncture drive unit 50 includes a switching part 51 , a linkage part 52 , an actuating part 56 , a supporting part 57 and a movable connection part 58 .

In this embodiment, each puncture driving unit 50 includes two switching parts 51 corresponding to the two puncture units 40 one-to-one. Each switching part 51 is drivingly connected or drivingly matched with the corresponding puncture unit 40, and is configured to drive the puncture unit 40 to switch between the first puncture operation state and the second puncture operation state. The two switching parts 51 are provided in conjunction with each other through the linkage part 52 to simultaneously drive the two puncture units 40 corresponding to the same kit accommodation space 20A, so that the two puncture units 40 can be synchronously switched from the first puncture operating state to the second puncture operating state. The puncture working state or the second puncture working state is synchronously switched to the first puncture working state.

The sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is drivingly connected or driven with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first puncture working state. When the movable part 5111 is in its second driving working position, the puncturing unit 40 is in the second puncturing working state.

As shown in Figures 23-30 and 32-37, the first movable part 5111 includes a first rotating component 51112, which is rotatably arranged relative to the warehouse body 11; the second movable part 5112 includes a second rotating component 51122. The second rotating component 51122 is rotatably arranged relative to the cartridge body 11 and is drivingly connected or driven with the first rotating component 51112. The second rotating component 51122 drives the puncture unit 40 in the first puncture working state and the second puncture working state. switch between.

In this embodiment, the first rotating component 51112 is a rotating shaft; the second rotating component 51122 includes a cam disposed on the rotating shaft, and the cam presses and fits with the puncture unit 40 . The cam is directly fixedly connected to the rotating shaft. In this embodiment, the rotating shaft and the cam on it are located outside the corresponding sampling needle mounting part 42 of the puncture unit 40. When the rotating shaft and the cam rotate, the rotation angle of the cam relative to the sampling needle mounting part 42 changes. , the cam drives the sampling needle installation part 42 to approach or move away from the reagent box accommodating space 20A, so that the puncture unit 40 switches between the first puncture working state and the second puncturing working state. The first movable part 5111, that is, the first driving working position of the rotating shaft corresponds to the position where the long axis of the cam contacts the sampling needle mounting part 42. The first movable part 5111, that is, the second driving working position of the rotating shaft corresponds to At the position where the short axis of the cam is in contact with the sampling needle mounting portion 42 .

In the embodiment shown in FIGS. 20 to 37 , the sampling needle driving mechanism 511 is configured to apply a force to the puncture unit 40 to switch from the second puncture operation state to the first puncture operation state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state.

Each adding needle reset mechanism 512 includes four springs 5121 , and the four springs 5121 are respectively provided at the four corners of the reagent cartridge storage unit 20 . Both ends of each spring 5121 are connected to the sampling needle mounting part 42 and the cross beam 571 . Each spring 5121 is a tension spring, thereby exerting a force on the side of the sampling needle mounting portion 42 away from the reagent cartridge storage unit 20 . That is, the sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch the puncture unit 40 from the first puncture operation state to the second puncture operation state.

As shown in Figures 23-24, 26-29, and 32-37, the linkage part 52 is drivingly connected or driven with the two switching parts 51 to make the puncture units 40 corresponding to the at least two switching parts 51 move synchronously. The linkage part 52 includes a first rotating component 51112 connected to the two switching parts 51 , that is, a belt transmission mechanism 522 between the rotating shafts.

The belt transmission mechanism 522 includes a pulley 5221 and a pulley 5222 respectively connected to two rotating shafts, and a conveyor belt 5223 installed on the

pulleys

5221 and 5222. Through the belt transmission mechanism 522, the two rotating shafts of the same puncture drive unit 50 rotate in the opposite direction synchronously, thereby driving the two cams to rotate in the opposite direction synchronously, and then drive the sampling needle mounting part 42 to move in the opposite direction synchronously, even if the upper and lower puncture units are 40 synchronously switches from the first puncture working state to the second puncture working state or synchronously switches from the second puncturing working state to the first puncture working state.

In the embodiment shown in FIGS. 20 to 37 , the actuating part 56 includes a rotating handle 562 , which is fixedly connected to the rotating shaft. The rotating handle 562 is provided on the side of the warehouse body 11 where the door 12 is provided, that is, front side. By turning the rotary handle 562, the rotating shaft can be driven to rotate, thereby driving the cam to rotate, causing the puncture unit 40 to switch between the first puncture working state and the second puncture working state.

The support part 57 is used to install the switching part 51 and the linkage part 52 . The support part 57 includes cross beams 571 respectively provided on the front and rear sides of each of the upper and lower sides of the warehouse body 11, a connecting beam 572 connected to the front and rear cross beams 571, and a longitudinal beam 572 connected to the upper and lower cross beams 571 on the rear side. Beam 573, two bearings 574 located in the bearing holes at the upper and lower ends of the longitudinal beam 573, each of the two upper and lower rotating shafts is installed on the cross beams 571 on its front and rear sides, and is rotatably supported on the two cross beams 571 On the top, both ends of the rotating shaft pass through corresponding beams 571 respectively, the end of the rotating shaft at the rear end passes through the corresponding bearing 574, and the end is connected to the

pulley

5221 or 5222, and the end of the rotating shaft at the front end is connected to the actuating part 56 connect. The cross beam 571 , the connecting beam 572 and the longitudinal beam 573 are all fixed on the kit storage unit 20 .

The movable connection part 58 is connected to the cam and the puncture unit 40 respectively, and is configured to transmit the movement of the cam to the puncture unit 40 so that the rotation of the cam drives the puncture unit 40 to move. As shown in FIGS. 29-30 , the movable connection part 58 includes a movable element 581 , a first pin 582 and a second pin 583 . The first pin 582 is provided on the end surface of the cam. The second pins 583 and the first pins 582 are arranged on the puncture unit 40 in parallel and spaced apart. The movable element 581 has an arc-shaped groove 581A. The movable element 581 is mounted on the cam and puncture unit 40 through a first pin 582 and a second pin 583 that cooperate with the arc-shaped groove 581A. The groove 581A is a sliding fit.

In the embodiment shown in FIGS. 20 to 37 , the components of the reagent storage device 1 located inside the reagent compartment 10 , such as the reagent cartridge storage unit 20 , the puncture unit 40 and the puncture drive unit 50 are all installed in the compartment body 11 of the reagent compartment 10 on the bottom wall.

For example, the detection unit 80 includes a reagent box detection part 81 that detects whether the reagent box 30 is installed in the reagent box accommodation space 20A, and/or includes a door detection part 82 that detects whether the door 12 is closed tightly. The reagent box detection unit 81 and the door detection unit 82 are, for example, electromagnetic sensors, photoelectric sensors, or the like.

The above embodiments are not intended to limit the present disclosure. For example, although the embodiments shown in Figures 1 to 19 of the present disclosure do not provide the detection unit 80, in modifications of this embodiment, the detection unit 80 may also be provided. For another example, Although the puncture driving unit 50 of the embodiment shown in FIGS. 20 to 37 does not include a limiting part, a guiding part and a positioning part, in some modifications of this embodiment, the limiting part, the guiding part and the positioning part may still be provided. At least one.

Figure 38 illustrates a reagent operating system according to an embodiment of the present disclosure. As shown in Figure 38, the reagent operating system provided by the embodiment of the present disclosure includes the reagent storage device 1 of the previous embodiment of the present disclosure. The reagent operating system also includes a reagent receiving part 2, a cleaning liquid transport part 3 and a gas communication part 4. The reagent receiving part 2 is in communication with the internal channel 41A of the sampling needle 41 of the puncture unit 40 located below the reagent cartridge accommodating space 20A. The gas communication part 4 and the cleaning liquid transport part 3 are respectively in communication with the internal channel 41A of the sampling needle 41 of the puncture unit 40 located above the reagent cartridge accommodating space 20A. The reagent receiving part 2 and the corresponding sampling needle 41 are connected through a connecting tube that passes through the cartridge body 11 and is sealed between the cartridge body 11 . The gas communication part 4 and the cleaning liquid transport part 3 are connected to the corresponding sampling needle 41 through a connecting pipe that passes through the cartridge body 11 and is sealed between the cartridge body 11 .

The reagent operating system may include a controller. The controller is used to control the operation of the reagent operating system. The controller is, for example, coupled to the reagent receiving part 2, the cleaning liquid delivery part 3 and/or the gas communication part 4. If the reagent storage device 1 includes a detection unit 80 and/or includes an actuator, the controller may also be coupled to the detection unit 80 and/or the actuator. Or the actuator is coupled to receive the detection signal of the detection unit 80 and/or to issue control instructions to the actuator. The controller can be implemented as a general-purpose processor, a programmable logic controller (PLC), a digital signal processor (DSP), or an application-specific integrated circuit for performing the functions described in this disclosure. (Application Specific Integrated Circuit, referred to as: ASIC), field-programmable gate array (Field-Programmable Gate Array, referred to as: FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, or any appropriate combination thereof.

The operation process of this reagent operating system is described as follows:

Open the compartment door 12, pull out the handle 561 to the frontmost position or turn the rotary handle 562 to position the puncture unit 40 in the second puncture working position. If there is a used reagent kit 30 inside, take it out and place the reagent kit 30 into the reagent box. Ensure that the box is installed in place within the box accommodation space of 20A. Push the handle 561 or turn the rotary handle to switch the puncture unit 40 from the second puncture working position to the first puncture working position, forcing the sampling needle mounting parts 42 of the upper and lower puncture units 40 and the sampling needle 41 thereon to face the reagent box at the same time The accommodation space 20A moves, and each reagent needle 41 penetrates into the weak portion 301 of the corresponding reagent box 30, so that the sampling needle hole 41B communicates with the corresponding reagent storage space 30A. Close the warehouse door 12.

After the reagent box 30 has been installed in place and the door 12 has been closed in place, the test process is started, and the reagent operating system completes relevant tests, including controlling the connection and disconnection of the reagent receiving part 2 and/or the gas communication part 4 and the reagent storage space 30A. . If there is a controller, relevant tests can be completed under the control of the controller. If there is a monitoring unit that is communicated with the controller, the position monitoring of the reagent box 30 and the door 12 can be carried out through the monitoring unit and the controller.

After the test is completed, the cleaning liquid transport part 3 is controlled to provide cleaning liquid to the corresponding reagent storage space 30A. The corresponding end of the sampling needle 41 at the bottom of the reagent storage space 30A is soaked in the cleaning liquid. The cleaning liquid can be emptied through external equipment. . By repeating different cleaning solutions multiple times, the sampling needle 41 can be cleaned to a required cleanliness level.

Open the compartment door 12, pull the handle 561 to the front or turn the rotary handle 562 to switch the puncture unit 40 to the second puncture working state. The sampling needle 41 is disconnected from the corresponding reagent storage space 30A, and the reagent box 30 can be pulled out. Complete the test cleaning process.

In this reagent operating system, the reagent receiving part 2 can introduce the reagents in the reagent box 30 into the reagent receiving part 2 to realize reagent transfer; the gas connecting part 4 can introduce gas into the reagent storage space 30A of the reagent box 30 when the reagent is transferred, This is beneficial to controlling the pressure of the reagent storage space 30A and the speed of reagent outflow; the cleaning liquid transport part 3 can introduce the cleaning liquid into the reagent box 30 after the reagent is transferred to clean the sampling needle 41 that has been in contact with the reagent to achieve sample addition. Needle 41 is cleaned.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention and not to limit it; although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the present invention can still be modified Modifications to the specific embodiments of the invention or equivalent substitutions of some of the technical features without departing from the spirit of the technical solution of the present invention shall be covered by the scope of the technical solution claimed by the present invention.

Claims

A reagent storage device (1), including:

A reagent warehouse (10) includes a warehouse body (11) and a warehouse door (12) used to close the warehouse body (11);

A reagent kit storage unit (20) is provided in the warehouse (11) and includes a reagent kit storage space (20A). The reagent kit storage space (20A) is configured to place a reagent storage space (30A). kit(30); and

The puncture unit (40) includes a sample adding needle (41) disposed in the cartridge body (11). The sample adding needle (41) has an internal channel (41A) and a puncture end (41C). The puncture end (41C) is provided with a sampling needle hole (41B) connected to the internal channel (41A), and the puncture unit (40) is movably arranged relative to the kit storage unit (20) and has a first In the puncturing working state and the second puncturing working state, the puncturing unit (40) is configured to: with the kit (30) placed in the kit accommodating space (20A), in the first In the puncture working state, the sample adding needle needle hole (41B) is connected with the reagent storage space (30A) of the kit (30). In the second puncture working state, the sample adding needle needle hole (41B) is connected to the reagent storage space (30A) of the kit (30). 41B) is disconnected from the reagent storage space (30A) of the reagent kit (30).
The reagent storage device (1) according to claim 1, wherein the reagent storage device (1) includes more than two puncture units (40) corresponding to the same reagent box accommodation space (20A). .
The reagent storage device (1) according to claim 2, wherein

Among the two or more puncture units (40) corresponding to the same kit accommodation space (20A), the puncture end (41C) of the sampling needle (41) of at least one of the puncture units (40) is located Outside or below the bottom of the corresponding kit containing space (20A); and/or

Among the two or more puncture units (40) corresponding to the same kit accommodation space (20A), the puncture end (41C) of the sampling needle (41) of at least one of the puncture units (40) is located The corresponding top outside or above the kit containing space (20A).
The reagent storage device (1) according to any one of claims 1 to 3, wherein the reagent box storage unit (20) includes a (20A), the kit protective part (21) has a puncture end escape opening (21A) for avoiding the puncture end (41C) of the sampling needle (41). .
The reagent storage device (1) according to any one of claims 1 to 4, wherein at least part of the sampling needle (41) of the puncture unit (40) includes:

A sample adding needle tube (411), the internal channel (41A) is located in the sample adding needle tube (411); and

The sampling needle tip (412) is located at the puncture end (41C) of the sampling needle (41) and is connected to one end of the sampling needle tube (411). The sampling needle tip (412) is from the The sampling needle tube (411) is a cone with a gradually decreasing cross-section toward the side away from the sampling needle tube (411); wherein the sampling needle hole (41B) is located in the sampling needle tube (41B). 411) on the side wall close to the tip (412) of the sampling needle.
The reagent storage device (1) according to any one of claims 1 to 5, wherein the sampling needle (41) includes a sampling needle tube (411) and a connecting rod located at the puncture end (41C). The sampling needle tip (412) of the sampling needle tube (411), wherein,

The sample adding needle tube (411) has at least one sample adding needle curved tube section (4112); and/or

The sample injection needle tube (411) has at least one flexible tube section; and/or

The sample adding needle tube (411) has at least one telescopic tube section.
The reagent storage device (1) according to claim 6, wherein the sample adding needle tube (411) includes:

The first straight tube section (4111) of the sampling needle extends along the surface of the chamber wall of the chamber body (11); and

The second sample adding needle straight tube section (4113) extends from one side of the chamber wall surface of the chamber body (11) to the kit accommodating space (20A). The second sample adding needle straight tube section (4113) One end of the sample adding needle is connected to one end of the first sampling needle straight pipe section (4111) through a sample adding needle curved pipe section (4112), and the sample adding needle tip (412) is connected to the second sample adding needle straight pipe section. The other end of pipe segment (4113).
The reagent storage device (1) according to any one of claims 1 to 7, wherein the puncture unit (40) further includes a sampling needle mounting part (42), and the sampling needle (41) is fixed on on the sampling needle mounting part (42).
The reagent storage device (1) according to any one of claims 1 to 8, wherein the reagent storage device (1) further includes a puncture drive unit (50), which includes a drive connection with the puncture unit (40). Or a driving-cooperated switching part (51) configured to drive the puncturing unit (40) to switch between the first puncturing working state and the second puncturing working state.
The reagent storage device (1) according to claim 9, wherein the reagent storage device (1) includes more than two puncture units (40), and the puncture drive unit (50) includes more than two puncture units (50) connected to the puncture unit. A switching part (51) corresponding to the unit (40), wherein at least two of the switching parts (51) are provided in interlocking manner.
The reagent storage device (1) according to claim 10, wherein the reagent storage device (1) includes more than two puncture units (40) corresponding to the same reagent box accommodation space (20A). , the puncture driving unit (50) includes more than two switching parts (51) corresponding to two or more puncture units (40) corresponding to the same kit accommodating space (20A), and The two or more switching parts (51) are provided in interlocking manner, so that the corresponding two or more puncture units (40) can synchronously switch from the first puncture working state to the second puncturing working state or from the The second puncture working state is synchronously switched to the first puncture working state.
The reagent storage device (1) according to any one of claims 9 to 11, wherein the puncture unit (40) includes a sampling needle mounting part (42) and a plurality of the sampling needles (41), The plurality of sampling needles (41) are installed on the sampling needle mounting part (42), and the switching part (51) and the sampling needle mounting part (42) of the puncture unit (40) The driving connection or driving cooperation drives the plurality of sampling needles (41) to move synchronously.
The reagent storage device (1) according to any one of claims 9 to 12, wherein the switching part (51) includes a sample adding needle driving mechanism (511), and the sample adding needle driving mechanism (511) is Configured to apply a force to the puncturing unit (40) to switch from the first puncturing working state to the second puncturing working state and/or to apply a force to switch the puncturing unit (40) from the second puncturing working state to the third puncturing working state. A force to switch the puncture working state.
The reagent storage device (1) according to claim 13, wherein the sampling needle driving mechanism (511) includes:

The first movable part (5111) has a first driving working position and a second driving working position;

The second movable part (5112) is drivingly connected or driven with the first movable part (5111) and the puncture unit (40) to transmit the action of the first movable part (5111) to the puncture unit. (40), wherein when the first movable part (5111) is in the first driving working position, the puncturing unit (40) is in the first puncturing working state and the second puncturing working state One, when the first movable part (5111) is in the second driving working position, the puncturing unit (40) is in the other one of the first puncturing working state and the second puncturing working state. .
The reagent storage device (1) according to claim 14, wherein the puncture driving unit (50) includes a linkage part (52), the linkage part (52) drives with at least two of the switching parts (51) The at least two switching parts (51) are connected or driven to cooperate so that the puncture units (40) corresponding to the at least two switching parts (51) move synchronously.
The reagent storage device (1) according to claim 14 or 15, wherein the puncture drive unit (50) includes:

Limiting part (53), the limiting part (53) is configured to limit the movement range of the first movable part (5111) and/or the second movable part (5112); and/or

Guide portion (54), the guide portion (54) is configured to guide the movement of the first movable portion (5111) and/or the second movable portion (5112).
The reagent storage device (1) according to claim 16, wherein

The limiting part (53) is configured to limit the movement range of the linkage part (52) to limit the movement range of the first movable part (5111) and/or the second movable part (5112); and /or

The guide portion (54) is configured to guide the movement of the linkage portion (52) to guide the movement of the first movable portion (5111) and/or the second movable portion (5112).
The reagent storage device (1) according to claim 16 or 17, wherein,

The limiting part (53) includes a limiting groove (53A) and a limiting surface (53B). The limiting surface (53B) is movably located in the limiting groove (53A) and connected with the limiting surface. The groove (53A) has an abutting state, and one of the limiting groove (53A) and the limiting surface (53B) is relative to the first movable part (5111) and the second movable part (5112) One of them is fixed, and the other is fixed relative to the other one of the first movable part (5111) and the second movable part (5112); and/or

The guide part (54) includes one or more guide structures, at least one guide structure includes a guide groove (54A) and a guide surface (54B), the guide surface (54B) is in sliding fit with the guide groove (54A), One of the guide groove (54A) and the guide surface (54B) is fixed relative to the cartridge body (11), and the other is fixed relative to the first movable part (5111) or the second movable part ( 5112) fixed.
The reagent storage device (1) according to any one of claims 14 to 18, wherein the puncture driving unit (50) further includes a positioning part (55), the positioning part (55) has a function to enable the puncture The unit (40) is maintained in a positioning state of the first puncture working state and/or the second puncture working state and an avoidance state that prevents interference with the switching working position of the puncture unit (40), and the positioning portion (55) It is movably arranged relative to the warehouse body (11) to switch between the avoidance state and the positioning state.
The reagent storage device (1) according to claim 19, wherein the positioning part (55) is driven and matched with the reagent box (30) to move in the avoidance direction driven by the reagent box (30). state and the positioning state.
The reagent storage device (1) according to claim 20, wherein the positioning part (55) includes a slider (551) and a slider reset mechanism (552), and the slider (551) is relative to the cartridge. The body (11) is movably installed in the cartridge body (11) and includes a positioning surface (5511D). The slider (551) drives and cooperates with the reagent box (30). In the positioning part (55) ), the slider (551) is in the avoidance position where the positioning surface (5511D) is separated from the second movable part (5112), and the slider reset mechanism (552) is in a power-accumulating state , in the positioning state of the positioning part (55), the slider (551) is in a positioning position where the positioning surface (5511D) contacts the second movable part (5112), and the slider (551) The reset mechanism (552) is in a force release state.
The reagent storage device (1) according to any one of claims 14 to 21, wherein,

The first movable part (5111) includes a first translation component (51111), which is reciprocally disposed relative to the cartridge body (11) along the first direction (X), so The first translation component (51111) is provided with a driving surface (51111A), the driving surface (51111A) is oriented along the first direction (X) toward a second direction (Z) perpendicular to the first direction (X). tilt;

The second movable part (5112) includes a second translation component (51121), which is fixedly arranged relative to the sampling needle (41) and relative to the cartridge body (11) Disposed reciprocally along the second direction (Z), the second translation component (51121) is provided with a mating surface (51121A) corresponding to the driving surface (51111A), and the mating surface (51121A) is arranged along the second direction (Z). The first direction (X) is tilted toward the second direction (Z), and by changing the position of the first translation member (51111) in the first direction (X), the driving surface (51111A) and The mating position of the mating surface (51121A) is to change the position of the second translation member (51121) along the second direction (Z).
The reagent storage device (1) according to claim 22, wherein the puncture driving unit (50) includes a linkage part (52), the linkage part (52) drives with at least two of the switching parts (51) Connect or drive and cooperate with the at least two switching parts (51) to cause the puncture units (40) corresponding to the at least two switching parts (51) to move synchronously, wherein,

The linkage part (52) includes a push-pull rod (521) extending along the first direction (X);

The first translation component (51111) is fixed on the push-pull rod (521), and the driving surface (51111A) is provided on a side of the push-pull rod (521) close to the second translation component (51121) ;

The second translation part (51121) includes a pressure plate, the pressure plate is arranged along the second direction (Z), and the mating surface (51121A) is provided on the pressure plate close to the first translation part (51111) Ends.
The reagent storage device (1) according to claim 23, wherein,

The puncture driving unit (50) includes a limiting portion (53) configured to limit the movement range of the linkage portion (52) to limit the movement of the first movable portion (5111). The limiter part (53) includes a limiter groove (53A) and a limiter surface (53B). The limiter surface (53B) is movably located in the limiter groove (53A) and connected with the limiter groove (53A). The limiting groove (53A) has an abutting state, one of the limiting groove (53A) and the limiting surface (53B) is provided on the second movable part (5112), and the other is provided on the second movable part (5112). on the push-pull rod (521); and/or

The puncture driving unit (50) includes a guide portion (54) configured to guide the movement of the linkage portion (52) and the first movable portion (5111). , the guide portion (54) includes one or more guide structures, at least one guide structure includes a guide groove (54A) and a guide surface (54B), and one of the guide groove (54A) and the guide surface (54B) is opposite to It is fixed on the warehouse body (11), and the other one is arranged on the push-pull rod (521).
The reagent storage device (1) according to any one of claims 14 to 20, wherein,

The first movable part (5111) includes a first rotating component (51112), which is rotatably arranged relative to the warehouse body (11);

The second movable part (5112) includes a second rotating part (51122). The second rotating part (51122) is rotatably arranged relative to the cartridge body (11) and is connected with the first rotating part (51112). ) driving connection or driving fit, the second rotating component (51122) drives the puncturing unit (40) to switch between the first puncturing working state and the second puncturing working state.
The reagent storage device (1) according to claim 25, wherein

The first rotating component (51112) is a rotating shaft;

The second rotating component (51122) includes a cam provided on the rotating shaft, and the cam is press-fitted with the puncture unit (40).
The reagent storage device (1) according to claim 26, wherein the puncture driving unit (50) further includes a movable connection part (58), the movable connection part (58) is respectively connected to the cam and the The puncture unit (40) is configured to transmit the motion of the cam to the puncture unit (40) so that the rotation of the cam drives the puncture unit (40) to move.
The reagent storage device (1) according to claim 27, wherein the movable connection part (58) includes:

The first pin (582) is provided on the end surface of the cam;

A second pin (583) is provided on the puncture unit (40) in parallel and spaced apart from the first pin (582);

The movable element (581) has an arc-shaped groove (581A). The movable element (581) communicates with the arc-shaped groove (581A) through the first pin (582) and the second pin (583). Couplingly installed on the cam and the puncture unit (40), the first pin (582) and the second pin (583) are in sliding fit with the arc-shaped groove (581A).
The reagent storage device (1) according to any one of claims 25 to 28, wherein,

The puncture driving unit (50) includes a linkage part (52), and the linkage part (52) is drivingly connected or driven with the at least two switching parts (51) so that the at least two switching parts (51) The corresponding puncture units (40) move synchronously;

The linkage part (52) includes a belt transmission mechanism (522), a chain transmission mechanism, a gear transmission mechanism, and a gear and rack transmission connected between the first rotating parts (51112) of the at least two switching parts (51). At least one of mechanism or linkage mechanism.
The reagent storage device (1) according to any one of claims 14 to 29, wherein the puncture driving unit (50) further includes an actuating part (56), the actuating part (56) and the The first movable part (5111) is drivingly connected or engaged; the actuating part (56) includes:

The handle (561) or the rotary handle (562) is drivingly connected or driven with the first movable part (5111), and the handle (561) or the rotary handle (562) is provided at the position of the warehouse body (11). The side with the warehouse door (12); or

The actuator is drivingly connected or drivingly matched with the first movable part (5111).
The reagent storage device (1) according to any one of claims 13 to 30, wherein the switching part (51) includes a sample needle reset mechanism (512), wherein,

One of the sampling needle driving mechanism (511) and the sampling needle reset mechanism (512) is configured to apply force to the puncture unit (40) from the first puncture working state to the third 2. The force for switching the puncture working state;

The other one of the sampling needle driving mechanism (511) and the sampling needle reset mechanism (512) is configured to apply force to the puncture unit (40) from the second puncture working state to the The force for switching the first puncture working state.
The reagent storage device (1) according to claim 31, wherein the sampling needle reset mechanism (512) includes at least one spring (5121); wherein,

The spring (5121) is located and/or connected between the puncture unit (40) and the kit storage unit (20); or

The spring (5121) is located and/or connected between the puncture unit (40) and the cartridge body (11).
The reagent storage device (1) according to any one of claims 1 to 32, wherein the reagent storage device (1) includes a plurality of the reagent cartridge storage units (20), and/or the reagent storage unit (1) The cartridge storage unit (20) includes a plurality of said reagent cartridge accommodation spaces (20A).
The reagent storage device (1) according to any one of claims 1 to 33, wherein the reagent storage device (1) further includes a heat preservation unit (60) configured to maintain the The temperature of the reagent compartment (10).
The reagent storage device (1) according to claim 34, wherein the heat preservation unit (60) includes a refrigerant circulation system (61), the refrigerant circulation system (61) is configured to regulate the reagent bin (10) internal temperature.
The reagent storage device (1) according to any one of claims 1 to 35, wherein,

The reagent storage device (1) includes a reagent box (30), the reagent box (30) includes a reagent storage space (30A), and the reagent box accommodation space (20A) of the reagent storage device (1) is used for Place the kit (30);

In the first puncture working state of the puncture unit (40), the sample needle hole (41B) is in contact with all the components of the kit (30) placed in the kit accommodating space (20A). The reagent storage space (30A) is connected. In the second puncture working state of the puncture unit (40), the sample needle hole (41B) is connected to the reagent box storage space (20A). The reagent storage space (30A) of the reagent kit (30) is disconnected.
The reagent storage device (1) according to claim 36, wherein the reagent box (30) has a weak portion (301) corresponding to the puncture end (41C) of the sampling needle (41), and in the In the first puncture working state of the puncture unit (40), the puncture end (41C) of the sample adding needle (41) enters the reagent storage space (30A) by piercing the weak part (301) to achieve the above The needle hole (41B) of the sample needle (41) is connected with the reagent storage space (30A) of the kit (30).
The reagent storage device (1) according to any one of claims 1 to 37, further comprising a bottom plate (70) located in the reagent compartment (10) and installed on the On the bottom wall of the compartment body (11), the kit storage unit (20) and/or the puncture unit (40) are installed on the bottom plate (70).
A reagent operating system, including the reagent storage device (1) according to any one of claims 1 to 38; wherein the reagent operating system further includes:

The reagent receiving part (2) is in communication with the internal channel (41A) of the sampling needle (41) of at least one of the puncture units (40); and/or

The cleaning liquid delivery part (3) is in communication with the internal channel (41A) of the sampling needle (41) of at least one of the puncture units (40); and/or

The gas communication part (4) is in communication with the internal channel (41A) of the sampling needle (41) of at least one puncture unit (40).
The reagent operating system according to claim 39, wherein,

The reagent operating system includes the reagent receiving part (2) and the cleaning fluid delivery part (3). The reagent receiving part (2) and the cleaning fluid delivery part (3) are respectively connected to different punctures. The internal channel (41A) of the sampling needle (41) of the unit (40) is in a connected state; and/or

The reagent operating system includes the cleaning liquid delivery part (3) and the gas communication part (4). The cleaning liquid delivery part (3) and the gas communication part (4) are connected to the same puncture unit ( The internal channel (41A) of the sampling needle (41) of 40) has a connected state at different periods of time.
The reagent operating system according to claim 39 or 40, wherein the reagent operating system includes the reagent receiving part (2) and the cleaning liquid delivery part (3), wherein,

The puncture end (41C) of the sampling needle (41) of the puncture unit (40) that is in communication with the reagent receiving part (2) is located at the bottom of the corresponding reagent box accommodation space (20A) Lateral or inferior;

The puncture end (41C) of the sampling needle (41) of the puncture unit (40) that is in communication with the cleaning liquid delivery part (3) is located at the corresponding side of the kit accommodating space (20A). Outside or above the top.
The reagent operating system according to any one of claims 39 to 41, wherein,

The reagent receiving part (2) is connected to the sampling needle (41) of at least one puncture unit (40) through a connecting tube with a flexible tube section or a telescopic tube section; and/or

The cleaning liquid delivery part (3) is connected to the sampling needle (41) of at least one puncture unit (40) through a connecting pipe with a flexible pipe section or a telescopic pipe section; and/or

The gas communication part (4) is connected to the sampling needle (41) of at least one puncture unit (40) through a connecting tube with a flexible tube section or a telescopic tube section.
The reagent operating system according to any one of claims 39 to 42, wherein,

The reagent receiving part (2) and the sampling needle (41) of at least one puncture unit (40) pass through the cartridge body (11) and are sealed with the cartridge body (11). Connecting pipe connections; and/or

The cleaning liquid delivery part (3) and the sampling needle (41) of at least one puncture unit (40) pass through the cartridge body (11) and are sealed with the cartridge body (11). connecting pipe connection; and/or

The gas communication part (4) and the sampling needle (41) of at least one puncture unit (40) pass through the cartridge body (11) and are sealed with the cartridge body (11). Connecting pipe connections.