WO2024042375A1 - Chewing gum containing natural anti-alzheimer disease and anti-cancer nano fenchol and nano quercetin - Google Patents
Chewing gum containing natural anti-alzheimer disease and anti-cancer nano fenchol and nano quercetin Download PDFInfo
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- WO2024042375A1 WO2024042375A1 PCT/IB2023/053395 IB2023053395W WO2024042375A1 WO 2024042375 A1 WO2024042375 A1 WO 2024042375A1 IB 2023053395 W IB2023053395 W IB 2023053395W WO 2024042375 A1 WO2024042375 A1 WO 2024042375A1
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- Prior art keywords
- nano
- quercetin
- fenchol
- gum
- producing
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- IAIHUHQCLTYTSF-UHFFFAOYSA-N 2,2,4-trimethylbicyclo[2.2.1]heptan-3-ol Chemical compound C1CC2(C)C(O)C(C)(C)C1C2 IAIHUHQCLTYTSF-UHFFFAOYSA-N 0.000 title claims abstract description 86
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
Definitions
- a producing chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in different forms and sizes or any kinds of other filling materials.
- Producing Saghez chewing gums having Nano Fenchol and Nano Quercetin gradual delivery is claimed because of low solubility in water and being enclosed in Natural gums polymer.
- producing process of chewing gum is started with the melting of the basic texture of chewing gum (Gum Base) for 10 minutes after that related sugar is added to it and combined together for 10 minutes, then other ingredients are added such as Fenchol and quercetin to combine thoroughly with others for 5 till 10 minutes, finally after forming the homogeneous texture transmitted to the device for producing 5-gram mold.
- the invention relates to a method for preparing Nano curcumin particles by utilizing an ultrasonic-assisted supercritical anti-solvent.
- the method comprises the following steps: adding curcumin into an organic solvent to prepare an organic solution, pumping CO2 into a high-pressure reaction kettle, and regulating the valve opening of the reaction kettle; pumping the prepared organic solution and starting an ultrasonic device after the pressure and temperature in the high-pressure reaction kettle are stabilized and reach preset values, continuing introducing CO2 after the solution is pumped, and keeping the pressure and temperature values in the high-pressure reaction kettle until the organic solvent is dried up to obtain the curcumin particles in the reaction kettle.
- the method has the advantages of short treatment time, high product purity and low amount of organic solvent residues.
- Disclosure provides a formulation of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin and to augment the biological activity of curcumin, wherein curcumin is the main constituent of curcuminoid and wherein Ar-turmerone is the main constituent of the essential oil of turmeric.
- curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin for oral supplementation against a variety of diseases and method of doing the same is provided.
- the present invention is directed to topically administering a compound represented by Structural Formula (I): a pharmaceutically acceptable salt thereof.
- the variables for Structural Formula (I) are defined herein.
- a pharmaceutical composition comprising the compound of Structural Formula (I).
- Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's Disease.
- the invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups.
- the curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
- compositions and methods for the treatment of a human patient include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
- the chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in the fields of food and Medical industry.
- the main and common component in all diseases such as different types of Cancers and alzheimers is the existent of oxidative stress and oxygen free Radicals production.
- Quercetin and Fenchol not only restrain producing ROS inside the body cells but also they prevent forming Amyloid plaques in brain as well as stimulating pathways of apoptosis inside the cancer cells besides having barrier properties for cardiovascular system.
- These substances are primarily produced in size of Nanoparticles then are used in Natural gums chewing gum produced from various natural sources. Drug delivery is gradually done having high permeation because of Natural gums and Nano structure.
- Producing Nanostructured drugs can increase its penetrance as well as targeted transmission. hence, producing every kind of food supplement, types of filling materials and flavored chewing gum including fenchol and quercetin can be effective for various diseases such as cancers of tongue, esophageal, stomach as well as Alzheimer disease.
- ROS reactive oxygen species
- chewing gum containing antioxidant and anticancer Nano fenchol and natural Nano quercetin due to its convenience and availability and on the other hand its popularity among people, as one of the suitable methods to transfer all kinds of drugs, not only in It can be used for patients with drug swallowing problems, but also for different groups of patients, in this case it can be used to solve the aforementioned problem, which is easily absorbed in epithelial cells due to its Nanostructure.
- ROS are signaling molecules used in biological processes.
- the biological cause of a range of diseases such as cancer, asthma, and pulmonary hypertension is a disruption in the equilibrium of oxygen free radicals and antioxidants.
- Fenchol and Quercetin-containing gum has anti-cancer and anti-ROS properties. Because of its Nano structure, it may have a direct and entirely targeted impact on all forms of oral malignancies (Liczbi ⁇ ski and et al 2020, University of South Florida (USF Health), October 5, 2021).
- Fenchol works in the gut on short-chain fatty acids (SCFAs). SCFAs then travel through the bloodstream to the brain, where they bind to and activate FFAR2 (free fatty acid receptor 2) receptors. When activated, this receptor protects the nervous system and prevents the formation of amyloid (A ⁇ ) accumulations and plaques (University of South Florida (USF Health), October 5, 2021).
- SCFAs short-chain fatty acids
- FFAR2 free fatty acid receptor 2
- Quercetin can prevent cancers such as breast, lung, nasopharyngeal, kidney, colorectal, prostate, esophageal, pancreatic, and ovarian cancer.
- the presence of two antioxidant pharmacophores in the structure of Quercetin accounts for its high ability to inhibit free radicals and bind to transition metal ions.
- the presence of catechol and the OH group at the C3 position of its structure provides an excellent configuration for free radical elimination.
- Quercetin is a pentahydroxy flavanol with 5 hydroxyl groups on carbons 3, 30, 40, 5, and 7 in its flavanol skeleton. The substitution of Quercetin's different functional groups results in its various biochemical and medicinal functions.
- Quercetin is a lipophilic compound that can cross cell membranes and activate a variety of intracellular signaling pathways involved in chemoprevention.
- Quercetin is a lipophilic compound that can cross cell membranes and activate a variety of intracellular signaling pathways involved in chemoprevention.
- Several studies have found Quercetin to have anticancer properties in a variety of cancers.
- One of Quercetin's unique properties is its ability to act as both a pro-oxidant and an antioxidant.
- Increased ROS due to oxidative stress causes DNA damage, which results in mutations. The mutation causes malignant tumor cells to grow uncontrollably.
- Quercetin can reduce ROS by donating electrons, resulting in less DNA damage caused by ROS.
- Quercetin is also known to induce apoptosis.
- Quercetin causes apoptosis by activating p53, increasing pro-apoptotic molecules like Bax and caspase-3, and decreasing anti-apoptotic factors like survivin and Bcl-2. Also, Quercetin has no toxic effect on healthy cells (Rana Shafabakhsh & Zatollah Asemi. 2019)
- the oven temperature was 30 degrees Celsius, and the solvent flow rate in the column was 1 ml/min. In addition, the amount of sample injected was 20 microliters.
- Nano Fenchol and Nano Quercetin are two of the components employed in this product (total 0.5 to 1 percent).
- Fenchol and Quercetin are synthesized in Nano size form by ultrasonication and the resultant extract is utilized to create chewing gum.
- the second aspect of slow release is the tiny size, which is contained in the gum polymer and arranged in countless numbers.
- the ingredients are blended in a predetermined size.
- the Fenchol gum is then packaged in sterile packaging.
- Nanostructures have the properties of gradual release as well as high penetration. Saghez (Natural gum) chewing gum derived from the Bene plant is combined with Nano Fenchol and Nano Quercetin in this invention. In addition to Nano Fenchol and Quercetin, various permitted herbal flavorings, such as mint or other flavorings, are added to this invention for flavoring.
- the gum substance itself has the property of gradual drug release (Ughade and et al 2012), whereas the presence of Nanostructures is the second factor of gradual drug release and also has the ability to penetrate deeper into cells.
- fennel and quercetin are extracted using permitted solvents and after purification, they are lyophilized, in the second step (a total of one gram of quercetin and fencol per hundred grams of chewing gum), the lyophilized powder of the extracts is copolymerized with turpentine from the origin of the gum, and in the next step, the permitted additives and flavorings are packed and covered.
- basil leaf and cactus fruit extracts are extracted using various solvents.
- the Fenchol and Quercetin are then separated using Hplc and fplc according to the protocol. After it has been approved, Fenchol and Quercetin are added, along with other permitted ingredients. Ultrasonication is used to prepare Fenchol and Quercetin in Nano size form, and the resulting extract is used to make chewing gum.
- the second factor of gradual release is the small size, which is encapsulated in the gum polymer and placed in countless numbers. The materials are combined in a predetermined size. Then the Fenchol gum is packed in sterile packages. We heat the container to between 30-38 degrees Celsius.
- the manufacturing process begins with 10 minutes of melting the gum base texture, followed by 10 minutes of mixing in the relevant sugars. Then add the remaining compounds, including Fenchol, and thoroughly mix for 5-10 minutes. The Fenchol within the gum polymer will be used via the weaving thread method. Finally, it is transferred to the machine for producing 5-gram molds after forming a homogeneous texture.
- This invention can also be produced as a food supplement and medicated and flavored chewing gum, which can be used to improve society's health and prevent disease by producing and supplying it. It is manufactured in the food industry as pharmaceutical supplements. Its most notable application is in the food industry and the production of flavored gums.
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Abstract
A producing chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in different forms and sizes or any kinds of other filling materials. Producing Saghez chewing gums having Nano Fenchol and Nano Quercetin gradual delivery is claimed because of low solubility in water and being enclosed in Natural gums polymer. at first, producing process of chewing gum is started with the melting of the basic texture of chewing gum (Gum Base) for 10 minutes after that related sugar is added to it and combined together for 10 minutes, then other ingredients are added such as Fenchol and quercetin to combine thoroughly with others for 5 till 10 minutes, finally after forming the homogeneous texture transmitted to the device for producing 5-gram mold.
Description
A producing chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in different forms and sizes or any kinds of other filling materials. Producing Saghez chewing gums having Nano Fenchol and Nano Quercetin gradual delivery is claimed because of low solubility in water and being enclosed in Natural gums polymer. at first, producing process of chewing gum is started with the melting of the basic texture of chewing gum (Gum Base) for 10 minutes after that related sugar is added to it and combined together for 10 minutes, then other ingredients are added such as Fenchol and quercetin to combine thoroughly with others for 5 till 10 minutes, finally after forming the homogeneous texture transmitted to the device for producing 5-gram mold.
A61C17/02; A61B1/015
Method for preparing Nano curcumin particles by utilizing ultrasonic-assisted
supercritical anti-solvent CN103705468A
The invention relates to a method for preparing Nano curcumin particles by utilizing an ultrasonic-assisted supercritical anti-solvent. The method comprises the following steps: adding curcumin into an organic solvent to prepare an organic solution, pumping CO2 into a high-pressure reaction kettle, and regulating the valve opening of the reaction kettle; pumping the prepared organic solution and starting an ultrasonic device after the pressure and temperature in the high-pressure reaction kettle are stabilized and reach preset values, continuing introducing CO2 after the solution is pumped, and keeping the pressure and temperature values in the high-pressure reaction kettle until the organic solvent is dried up to obtain the curcumin particles in the reaction kettle. Compared with the prior art, the method has the advantages of short treatment time, high product purity and low amount of organic solvent residues.
Formulation of Curcumin with Enhanced Bioavailability of Curcumin and method of preparation and treatment thereof
United States Patent Application 20190060253
Disclosure provides a formulation of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin and to augment the biological activity of curcumin, wherein curcumin is the main constituent of curcuminoid and wherein Ar-turmerone is the main constituent of the essential oil of turmeric. An application of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin for oral supplementation against a variety of diseases and method of doing the same is provided.
Method of Topically Administering a Curcumin Derivative
United States Patent Application 20160374960
The present invention is directed to topically administering a compound represented by Structural Formula (I): a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I).
Curcumin-Resveratrol hybrid molecule
United States Patent 7745670
Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's Disease.
Curcumin and tetrahydrocurcumin derivatives
United States Patent 9447023
The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
Liposomal Curcumin for Treatment of Diseases
United States Patent Application 20180318217
The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
The chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in the fields of food and Medical industry. The main and common component in all diseases such as different types of Cancers and alzheimers is the existent of oxidative stress and oxygen free Radicals production. Quercetin and Fenchol not only restrain producing ROS inside the body cells but also they prevent forming Amyloid plaques in brain as well as stimulating pathways of apoptosis inside the cancer cells besides having barrier properties for cardiovascular system. These substances are primarily produced in size of Nanoparticles then are used in Natural gums chewing gum produced from various natural sources. Drug delivery is gradually done having high permeation because of Natural gums and Nano structure. Producing Nanostructured drugs can increase its penetrance as well as targeted transmission. hence, producing every kind of food supplement, types of filling materials and flavored chewing gum including fenchol and quercetin can be effective for various diseases such as cancers of tongue, esophageal, stomach as well as Alzheimer disease.
ROS (reactive oxygen species) is a common factor in all diseases, especially cancer and neurodegenerative diseases. On the other hand, due to the significant increase in smoking and non-observance of oral and dental hygiene, various types of diseases, especially tongue and esophagus cancer, have also increased. Delivering the drug to the epithelial cells of the mouth and esophagus is a fundamental problem in the treatment of this disease due to its ephemerality on the one hand and the difficulty of swallowing in various people with complications in the mouth and esophagus on the other hand. In recent years, many advances have been made in the field of drug delivery methods. Among these methods that can release the drug in a targeted manner, chewing gum can be mentioned. In this invention, chewing gum containing antioxidant and anticancer Nano fenchol and natural Nano quercetin due to its convenience and availability and on the other hand its popularity among people, as one of the suitable methods to transfer all kinds of drugs, not only in It can be used for patients with drug swallowing problems, but also for different groups of patients, in this case it can be used to solve the aforementioned problem, which is easily absorbed in epithelial cells due to its Nanostructure.
ROS are signaling molecules used in biological processes. A shift in the balance of the extent of oxygen free radicals created and the antioxidant defense, on the other hand, may cause damage to internal cellular organelles and normal physiological functions. Moreover, the biological cause of a range of diseases such as cancer, asthma, and pulmonary hypertension is a disruption in the equilibrium of oxygen free radicals and antioxidants. As a result, a comprehensive knowledge of this topic may lead to the discovery of the cause and treatment of numerous illnesses. Fenchol and Quercetin-containing gum has anti-cancer and anti-ROS properties. Because of its Nano structure, it may have a direct and entirely targeted impact on all forms of oral malignancies (Liczbiński and et al 2020, University of South Florida (USF Health), October 5, 2021).
Fenchol works in the gut on short-chain fatty acids (SCFAs). SCFAs then travel through the bloodstream to the brain, where they bind to and activate FFAR2 (free fatty acid receptor 2) receptors. When activated, this receptor protects the nervous system and prevents the formation of amyloid (Aβ) accumulations and plaques (University of South Florida (USF Health), October 5, 2021).
Extensive research has shown that Quercetin can prevent cancers such as breast, lung, nasopharyngeal, kidney, colorectal, prostate, esophageal, pancreatic, and ovarian cancer. The presence of two antioxidant pharmacophores in the structure of Quercetin accounts for its high ability to inhibit free radicals and bind to transition metal ions. Furthermore, the presence of catechol and the OH group at the C3 position of its structure provides an excellent configuration for free radical elimination. Quercetin is a pentahydroxy flavanol with 5 hydroxyl groups on carbons 3, 30, 40, 5, and 7 in its flavanol skeleton. The substitution of Quercetin's different functional groups results in its various biochemical and medicinal functions. Quercetin is a lipophilic compound that can cross cell membranes and activate a variety of intracellular signaling pathways involved in chemoprevention. Several studies have found Quercetin to have anticancer properties in a variety of cancers. One of Quercetin's unique properties is its ability to act as both a pro-oxidant and an antioxidant. Increased ROS due to oxidative stress causes DNA damage, which results in mutations. The mutation causes malignant tumor cells to grow uncontrollably. Quercetin can reduce ROS by donating electrons, resulting in less DNA damage caused by ROS. At high concentrations, Quercetin is also known to induce apoptosis. The main mechanism by which Quercetin induces apoptosis has been identified as a mitochondria-mediated pathway. Quercetin causes apoptosis by activating p53, increasing pro-apoptotic molecules like Bax and caspase-3, and decreasing anti-apoptotic factors like survivin and Bcl-2. Also, Quercetin has no toxic effect on healthy cells (Rana Shafabakhsh & Zatollah Asemi. 2019)
The steps are as follows:
- In the first phase, basil leaf or cactus fruit extracts are extracted using various solvents (any origin or plant that contains Fenchol and Quercetin compounds, or Quercetin and Fenchol itself can also be used).
This is accomplished with the use of a Soxhlet apparatus and various solvents. To separate the heavy oily hydrocarbons and waxes, ethanol is added to it and stirred for one hour before being maintained at -15 degrees for evaporation and filtration.
2. Fenchol and Quercetin are separated using Hplc and fplc according to the protocol.
For this aim, in order to separate better from the process of soaking in solvent and extracting with hexane, column chromatography was done on silica gel 60 in a column with a length of 50 cm and a diameter of 2 cm, and lastly, the HPLC spectrum was created.
Knuer's Well Chrom 2000 HPLC apparatus with the Stark 1000 Maxi pump and the Eurospher 100 C18 detector with a diameter of 4 mm and a length of 25 cm was utilized for this.
Methanol/water/acetic acid in 5/45/50 proportions were utilized as the mobile phase. Each analysis took 60 minutes to complete.
The oven temperature was 30 degrees Celsius, and the solvent flow rate in the column was 1 ml/min. In addition, the amount of sample injected was 20 microliters.
3. After its approval, fenchol and quercetin are added to it along with other permitted compounds.
Nano Fenchol and Nano Quercetin are two of the components employed in this product (total 0.5 to 1 percent).
Starch, sorbitol, lecithin, peppermint essence, allowed and natural food additives, Beneh tree Saghez (with standard percentage).
4. Fenchol and Quercetin are synthesized in Nano size form by ultrasonication and the resultant extract is utilized to create chewing gum. The second aspect of slow release is the tiny size, which is contained in the gum polymer and arranged in countless numbers. The ingredients are blended in a predetermined size. The Fenchol gum is then packaged in sterile packaging.
5. We bring the container to a temperature of 30-38 degrees Celsius. The manufacturing process starts by melting the gum base texture for 10 minutes, then the relevant sugars are added to it and mixed together for 10 minutes. Then add the rest of the ingredients including fenchol and quercetin, and mix completely for 5 to 10 minutes. Rhys buffering method will be used to transfer fenchol inside the chewing gum polymer. Finally, after forming a homogeneous texture, it is transferred to the machine for producing 5 gram molds.
Mixture test:
This research was conducted on Alzheimer's model mice.
- Alzheimer's model mice were created using manganese Nano powder (60 mg/mouse for two weeks as an intraperitoneal injection) and were validated using molecular tests and histopathology.
- Alzheimer's rats model were split into three groups: gavage treatment, oral treatment, and intraperitoneal injection treatment.
- To apply the treatment in the form of intraperitoneal injection in doses of 0.5, 1 and 2 cc (3 mg per cc) for one week.
- In accordance with medical ethics protocols, the samples were anesthetized with ether and the spinal cord was cut. Then, the rats' brains were surgically removed and samples were taken from the hippocampus.
- Molecular and histopathology tests were performed on hippocampus samples.
Because pharmaceutical forms and other combinations of substances containing Fenchol and Quercetin are not easily available and usable, chewing gum to administer Fenchol can easily solve this problem. Nanostructures, on the other hand, have the properties of gradual release as well as high penetration. Saghez (Natural gum) chewing gum derived from the Bene plant is combined with Nano Fenchol and Nano Quercetin in this invention. In addition to Nano Fenchol and Quercetin, various permitted herbal flavorings, such as mint or other flavorings, are added to this invention for flavoring.
The gum substance itself has the property of gradual drug release (Ughade and et al 2012), whereas the presence of Nanostructures is the second factor of gradual drug release and also has the ability to penetrate deeper into cells.
Gradual release and treatment of cells that are at risk of increased ROS levels.
Due to the ease of use, no restriction of use for different ages and accessibility.
Direct effect using drug delivery technique for targeted drug delivery.
Use of natural sugars such as sorbitol due to the absence of tooth decay.
Transfer correctly and in the right amount of fennel and quercetin.
No toxicity in high doses of fencol and quercetin.
Benefiting from the beneficial effects of fennel and quercetin for the body.
Compliance with the standards of the amount of effective substance in each gum.
Synergistic effect of quercetin and fencol together without creating negative interaction.
Direct effect on mouth, esophagus and stomach cancers.
Examples
In the first step, basil leaf and cactus fruit extracts are extracted using various solvents. The Fenchol and Quercetin are then separated using Hplc and fplc according to the protocol. After it has been approved, Fenchol and Quercetin are added, along with other permitted ingredients. Ultrasonication is used to prepare Fenchol and Quercetin in Nano size form, and the resulting extract is used to make chewing gum. The second factor of gradual release is the small size, which is encapsulated in the gum polymer and placed in countless numbers. The materials are combined in a predetermined size. Then the Fenchol gum is packed in sterile packages. We heat the container to between 30-38 degrees Celsius. The manufacturing process begins with 10 minutes of melting the gum base texture, followed by 10 minutes of mixing in the relevant sugars. Then add the remaining compounds, including Fenchol, and thoroughly mix for 5-10 minutes. The Fenchol within the gum polymer will be used via the weaving thread method. Finally, it is transferred to the machine for producing 5-gram molds after forming a homogeneous texture.
| B | A |
| D | C |
| F | E |
| G | |
| B |
A |
Table 3. Comparison of the mean relative expression of APP (A) and MAPT (B) genes in different treatments in the hippocampal region of rats compared to Alzheimer's rats.
The development of flavored gums with gradual drug release properties can be beneficial in both prevention and treatment. This invention can also be produced as a food supplement and medicated and flavored chewing gum, which can be used to improve society's health and prevent disease by producing and supplying it. It is manufactured in the food industry as pharmaceutical supplements. Its most notable application is in the food industry and the production of flavored gums.
Claims (6)
- A producing the chewing gum consisting of natural Nano Fenchol and Nano Quercetin which is anti-Alzheimer and also anticancer in different forms and size or any kinds of other fulling materials. Producing Saghez chewing gums having Nano Fenchol and Nano Quercetin gradual delivery is claimed because of low solubility in water and being enclosed in Natural gums polymer.
- according to the Claim 1, mentioned above, extracting basil leaves and prickly pear by using different solvents for producing Natural gums like Saghez.(every source or plant including Fenchol and Queretin or their ingredients can be used).
- according to the Claim 2, Fenchol and Quercetin are separated according to the protocol by using fplc and Hplc and Fenchol and Quercetin along with other ingredients are added altogether to gum. Generally all materials and ingredients used in this product includes: Nano Fenchol and Nano Quercetin (totally from 0.5 to 1 percentage),starch, Sorbitol, lecithin, mint essence, permitted natural food additives and gum originating at Bone tree(including the standard percentage).
- according to the Claim 3, Fenchol and quercetin in Nano size are produced by ultrasonication and the resulting extract is used to produce chewing gum. Synthesis of Nano fenchol and Nano quercetin encapsulated with copolymerized gum is transformed into Nano form by ultrasonic method and then lyophilized.
- according to the Claim 4, Gum polymer particles are copolymerized and Nano quercetin and Nano fenchol are enclosed by gum polymer.
- according to the Claim 5, at first, producing process of the chewing gum is started with melting of the basic texture of chewing gum (Gum Base) during 10 minutes after that related sugar added to it and combined together for 10 minutes, then other ingredients added such as Fenchol and quercetin to combine thoroughly with others for 5 till 10 minutes, finally after forming the homogeneous texture transmitted to the device for producing 5-gram mold.
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| EP1886662A1 (en) * | 2006-06-14 | 2008-02-13 | Symrise GmbH & Co. KG | Anti-microbial compounds for treating bad breath |
| WO2020037410A1 (en) * | 2018-08-20 | 2020-02-27 | Hexo Operations Inc. | Cannabis-infused product with enhanced cannabinoid profile user experience |
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| EP1886662A1 (en) * | 2006-06-14 | 2008-02-13 | Symrise GmbH & Co. KG | Anti-microbial compounds for treating bad breath |
| WO2020037410A1 (en) * | 2018-08-20 | 2020-02-27 | Hexo Operations Inc. | Cannabis-infused product with enhanced cannabinoid profile user experience |
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