WO2024035681A2 - Dispositif de verrouillage, système et procédé d'utilisation associé - Google Patents

Dispositif de verrouillage, système et procédé d'utilisation associé Download PDF

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Publication number
WO2024035681A2
WO2024035681A2 PCT/US2023/029706 US2023029706W WO2024035681A2 WO 2024035681 A2 WO2024035681 A2 WO 2024035681A2 US 2023029706 W US2023029706 W US 2023029706W WO 2024035681 A2 WO2024035681 A2 WO 2024035681A2
Authority
WO
WIPO (PCT)
Prior art keywords
locking device
locking
opposing
slot
locked position
Prior art date
Application number
PCT/US2023/029706
Other languages
English (en)
Other versions
WO2024035681A3 (fr
Inventor
David R. Tholfsen
Patrick P. Wu
Original Assignee
Mvrx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN202210990971.XA external-priority patent/CN115444477A/zh
Application filed by Mvrx, Inc. filed Critical Mvrx, Inc.
Publication of WO2024035681A2 publication Critical patent/WO2024035681A2/fr
Publication of WO2024035681A3 publication Critical patent/WO2024035681A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
    • A61B2017/0488—Instruments for applying suture clamps, clips or locks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
    • A61B2017/049—Instruments for removing suture clamps, clips or locks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B2017/0496—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve

Definitions

  • the present invention relates generally to medical devices and procedures, and more particularly to a device, system and method for locking a suture or wire to prevent movement of the suture or wire during a medical procedure.
  • the lock is a three part system where there is a jaw, an outer shell and a compression spring that keeps the edges of the jaw and shell close together. To open the lock the spring must be compressed to push the edges of the jaw and shell apart. This design is limited by how much the edges of the jaw and shell can be pulled apart from each other. This in turn limits the size of the suture/tensioning element or other components that are bonded to the suture.
  • Embodiments of the invention are directed to systems, methods and associated devices for locking a suture or wire during a medical procedure, such as placement of a medical implant in a subject.
  • the systems, methods and devices described herein are particularly useful for delivery and deployment of heart implants for reshaping a heart valve annulus for treatment of a heart disorder, such as mitral valve regurgitation.
  • the invention provides a locking device that includes: a body having a first opposing member connected to a second opposing member by a hinge element, each opposing member being resiliently movable about the hinge element between a locked position and an unlocked position, wherein the hinge is configured to maintain a compressive force between opposing surfaces of the opposing members; a channel disposed adjacent the body and extending partially or entirely through a thickness of the body; and a slot disposed adjacent the channel, the slot being open when the device is transitioned from the locked position to the unlocked position.
  • the opposing surfaces are separated from one another in the unlocked position and the slot is open and are in close proximity to one another in the locked position to apply a compressive force to an object within the slot and the slot is closed.
  • the invention provides a locking device that includes: a disc body having an outer perimeter surface and a first opposing member connected to a second opposing member by a hinge element, each opposing member being resiliently movable about the hinge element between a locked position and an unlocked position, wherein the hinge formed by a strip of the body connecting the first and second opposing members and configured to maintain a compressive force between opposing surfaces of the opposing members; a channel disposed adjacent the body and extending through a thickness of the body; and a slot disposed adjacent the channel, the slot being open when the device is transitioned from the locked position to the unlocked position.
  • the slot is defined by a groove in the opposing surface of the first opposing member or the opposing surface of the second opposing member and the slot is shaped to accommodate a ridge formed on the opposing surface, and the hinge, slot and channel are aligned along a midline of the body in the locked position with the channel being disposed in the center of the body.
  • the opposing surfaces are separated from one another in the unlocked position and the slot is open, and the opposing surfaces are in close proximity to one another and apply a compressive force to an object within the slot in the locked position and the slot is closed.
  • the invention provides a locking assembly.
  • the locking assembly includes 2 or more locking devices of the invention, wherein each locking device is arranged such that the hinge and channel of each locking device are aligned.
  • the invention provides a locking system.
  • the locking system includes: the locking device or the locking assembly of the invention; and a medical device detachably coupled to the locking device or locking assembly.
  • the invention provides a method of performing a surgical procedure.
  • the method includes: advancing the locking device or locking assembly to a location within a subject; transitioning the locking device or locking assembly to the unlocked position; tensioning a tensioning element traversing the slot; and transitioning the locking device or locking assembly to the locked position.
  • the invention provides a method of treating mitral valve regurgitation in a subject by reshaping an atrial heart chamber of the subject.
  • the method includes: advancing the locking device or locking assembly of the disclosure to a first location of the heart within the subject, wherein the locking device or locking assembly is coupled to an expandable anchor implant; deploying the expandable anchor implant at the first location by tensioning the tensioning element when the locking device or locking assembly is in the unlocked position; transitioning the locking device or locking assembly to the locked position; detaching the catheter from the locking device or locking assembly; deploying a second expandable anchor at a second location of the heart, wherein the first and second expandable anchors are coupled via a bridging element traversing the heart chamber; and tensioning the bridging element to reshape the heart chamber, thereby treating mitral valve regurgitation in the subject.
  • Figure 1 is a perspective view of a locking device in the locked position in an embodiment of the invention.
  • Figure 2 is a perspective view of the locking device depicted in Figure 1 in the unlocked position via application of an expanding member.
  • Figure 3 illustrates a locking assembly in the unlocked position in an embodiment of the invention.
  • Figure 4 depicts the locking assembly of Figure 3 in the locked position.
  • Figure 5 illustrates a locking assembly in an embodiment of the invention.
  • Figure 6 illustrates a locking device in the locked position in an embodiment of the invention.
  • Figure 7 depicts the locking assembly of Figure 6 in the unlocked position.
  • Figure 8 depicts the locking assembly of Figure 6 in the unlocked position.
  • Figure 9 depicts the locking assembly of Figure 6 in the locked position.
  • Figure 10 depicts the locking assembly of Figure 6 in the locked position.
  • Figure 11 illustrates a locking assembly in the locked position in an embodiment of the invention.
  • Figure 12A depicts the locking assembly of Figure 9 in the unlocked position.
  • Figure 12B depicts the locking assembly of Figure 9 in the unlocked position with a suture traversing the slot.
  • Figure 12C depicts the locking assembly of Figure 9 transitioning from the unlocked position to the locked position by removal of the expanding member.
  • Figure 12D depicts the locking assembly of Figure 9 in the locked position.
  • Figure 13 illustrates a locking assembly in the locked position in an embodiment of the invention.
  • Figure 14A depicts the locking assembly of Figure 11 in the unlocked position.
  • Figure 14B depicts the locking assembly of Figure 11 in the unlocked position with a suture traversing the slot.
  • Figure 14C depicts the locking assembly of Figure 11 transitioning from the unlocked position to the locked position by removal of the expanding member.
  • Figure 14D depicts the locking assembly of Figure 11 in the locked position.
  • Figure 15 illustrates a locking system in an embodiment of the invention.
  • Figure 16 illustrates a locking system in an embodiment of the invention.
  • Figure 17 is an expanded view of the locking system depicted in Figure 16.
  • the present invention relates to systems, methods and associated devices for locking a tensioning element, such as a bridging element, suture, wire or string, during a medical procedure, such as placement of a medical implant in a subject.
  • a tensioning element such as a bridging element, suture, wire or string
  • the systems, methods and devices described herein are particularly useful for delivery and deployment of heart implants for reshaping a heart valve annulus for treatment of a heart disorder, such as mitral valve regurgitation.
  • embodiments of the invention are directed to a locking device for reversibly securing a tensioning element, such as a suture or wire, under tension during a surgical procedure.
  • the device is capable of securing the tensioning element under tension without slipping of the tensioning element which, for example, would result in the incorrect deployment of a medical implant, such as a septal implant.
  • the locking device 10 includes a body 20 having a first opposing member 30 connected to a second opposing member 40 by a hinge element 50, a channel 60 disposed adjacent the body 20 and extending partially or entirely through a thickness of the body, a slot 70 disposed adjacent the channel 60, and optionally one or more aligning holes 45.
  • Each opposing member (30, 40) is resiliently movable about the hinge element 50 between a locked position as shown in Figure 1, and an unlocked position as shown in Figure 2.
  • the hinge element 50 is configured to maintain a compressive force between opposing surfaces (80, 90) of the opposing members (30, 40).
  • the slot 70 is open when the device 10 is transitioned from the locked position to the unlocked position.
  • the opposing surfaces (80, 90) are separated from one another in the unlocked position and the slot 70 is open as shown in Figure 2.
  • the opposing surfaces (80, 90) are in close proximity to one another to apply a compressive force to an object within the slot 70 and the slot 70 is closed as shown in Figure 1.
  • the opposing surfaces (80, 90) are operable to apply a compressive force to a tensioning element traversing the slot 70 in the locked position.
  • the body 20 has an outer perimeter surface 100 surrounding the first opposing member 30, the second opposing member 40, and the hinge element 50 connecting the opposing members.
  • the body 20 is defined by a planar substrate having a front surface 110 and an opposing back surface 120, the surfaces being bound by the outer perimeter surface 100.
  • the opposing front and back surfaces 110, 120
  • the surfaces may be virtually any geometric shape.
  • the surfaces may be circular, elliptical, oval, square, rectangular, triangular, hexagonal and the like.
  • the locking device 10 includes a channel 60 that traverses the entire thickness of the body 20. As shown in Figure 1, when the device is in the locked position, the channel 60 has a rectangular or square shape. The channel 60 is configured to engage and interact with an expanding member 140 having a distal tip 150 sized to fit within the channel 60 in when the device is in the locked position and transition the device to the unlocked position by rotating the distal tip 150 of the expanding member 140 within the channel 60 as shown in Figure 2.
  • the channel 60 and distal tip 150 of the expanding member may have a variety of corresponding shapes while maintaining the same functionality of interaction to transition the device from the locked position to the unlocked position.
  • the channel is rectangular, square, triangular, hexagonal, ovoid or ellipsoid and the distal tip is sized and shaped to be inserted into the channel when the device is in the locked position and expand the channel and slot to transition the device to the unlocked position.
  • FIG. 1 shows the slot 70 such that the tensioning member may freely move through the open slot of the device.
  • Figure 2 shows the device in the unlocked position in which the slot 70 is open.
  • the slot 70 is defined by a groove formed in one of the opposing surfaces of an opposing member which receives a ridge formed on the opposing surface of the other opposing member.
  • Figure 2 shows the slot 70 being defined by a groove 160 formed in the opposing surface 80 of the first opposing member 30 which receives a ridge 170 formed on the opposing surface 90 of the second opposing member 40.
  • the hinge element 50, channel 60 and slot 70 are symmetrically aligned along the midline of the device 10 with the channel being centrally located and the hinge and slot being on opposing sides of the channel when the device is in the locked position as shown in Figure 1. This allows multiple locking devices 10 to be linked together to form a locking assembly.
  • the invention provides a locking assembly.
  • the locking assembly includes 2, 3, 4, 5, 6, 7, 8, 9, 10 or more locking devices aligned in succession.
  • each locking device is arranged such that the hinge and channel of each locking device are aligned.
  • each locking device is arranged front to back in an alternating manner.
  • each locking device is arranged back to back in an alternating manner.
  • each locking device is arranged front to front in an alternating manner.
  • each locking device is arranged back to back, front to front, back to back and so on.
  • Figures 3-5 show locking assemblies 200 that include multiple locking devices 10.
  • the individual locking devices 10 that comprise a locking assembly 200 may be optionally coupled to one another in an alternating fashion such that the slot, channel and hinge element of each device are aligned along the longitudinal axis of the assembly and the back surface of one device faces the back surface of another device as shown in Figures 3-5.
  • This allows the individual slots of each device to be offset from one another when the assembly is in the locked position (e.g., each individual locking device is in the locked position) resulting in increased gripping of the tensioning element that traverses the slots to prevent slipping of the tensioning element when the element is under tension during a surgical procedure.
  • the compressive force applied by the opposing surfaces on the tensioning element when the device 10 is in the locked position is generated by the hinge element 50.
  • the hinge element 50 is composed of a resilient shape memory material having a memory that naturally urges that opposing surfaces toward each other to grip and object.
  • the shape memory material of the hinge element is configured to resiliently return to the locked position from the unlocked position.
  • materials include polymers, composites, ceramics and alloys, such as nickel-titanium (NiTi) alloy, i.e. , nitinol, and steel.
  • the hinge element 50 need not be formed of a shape memory material.
  • the compressive force applied by the opposing surfaces (80, 90) on the tensioning element when the device 10 is in the locked position is generated by a collar 180 that at least partially surrounds the outer perimeter surface 100 as shown in Figures 6-11.
  • the collar 180 is composed of a resilient shape memory material having a memory that naturally urges that opposing surfaces toward each other to grip and object.
  • the shape memory material of the hinge element is configured to resiliently return to the locked position from the unlocked position.
  • Such materials include polymers, composites, ceramics and alloys, such as nickel-titanium (NiTi) alloy, i.e., nitinol, and steel.
  • the hinge element 50 and the collar 180 are both formed of shape memory material.
  • Figure 11 shows a locking assembly 200 that includes a plurality of individual locking devices 10 as depicted in Figures 1 and 2, aligned in an alternating manner and surrounded by the collar 180.
  • Figure 11 shows the assembly 200 in the locked position gripping a tensioning element 190 that traverses the respective slots of the individual locking devices 10.
  • the expanding member 140 is inserted into one or more channels 60 to expand the slots 70 and transition the assembly 200 to the unlocked position as shown in Figure 12A.
  • the tensioning element 190 is inserted through the respective slots of the assembly while the assembly 200 is unlocked with the expanding member 140 being in engagement with the one or more channels 60 as shown in Figure 12B.
  • the locking device does not include a hinge element.
  • the locking device includes opposing members (30, 40) that are separate and contained within the collar 180 without a hinge.
  • the opposing members are separate from one another and the orientation and shape of the collar (e.g., c-shape) allows the device to be transitioned from the locked position to the unlocked position.
  • the compressive force applied by the opposing surfaces (80, 90) on the tensioning element when the device is in the locked position is generated by the collar 180 that partially surrounds the body 20 with the opening of the collar being disposed adjacent the slot 20 and the closed portion of collar being disposed opposite the slot.
  • FIGS 6-10 and 13 illustrate an embodiment of the device 10 that includes opposing members (30, 40) and the collar 180.
  • Each opposing member includes multiple opposing surfaces of grooves and ridges that form the slot, each opposing member being connected by a hinge element that includes a pin 220 that traverses the length of the device.
  • the opposing members freely rotate about the pin 220 of the hinge element to allow the device to transition between the locked and unlocked position.
  • the compressive force applied by the opposing surfaces of the opposing members (30, 40) on the tensioning element when the device is in the locked position is generated by the collar 180.
  • the locking device 10 or locking assembly 200 is detachably coupled to medical device, such as a delivery catheter or medical implant.
  • embodiments of the invention provide a locking system that includes the locking device or locking assembly of the disclosure and a medical device detachably coupled to the locking device or locking assembly.
  • Figures 14A-14D illustrate delivery of the locking device 10 depicted in Figure 13 via a delivery catheter 210.
  • Figure 14A shows the locking device 10 in the locked position and coupled to the delivery catheter 210.
  • the distal tip 150 of the expanding member 140 is inserted into the channel 60 to expand the locking device and transition the device from the locked position to the unlocked position as shown in Figure 14B.
  • a tensioning element 190 is passed through the open slots of the locking device 10 and the delivery catheter 210 when the locking device is in the unlocked position as shown in Figure 14C. Once the tensioning element 190 is appropriately tensioned, the expanding member is removed and the locking device 10 transitions to the closed position gripping the tensioning element 19 as shown in Figure 14D.
  • the delivery catheter can then be uncoupled from the locking device if desired.
  • Figures 15-17 illustrate a locking system 300 in an embodiment of the invention in which the locking device 10 or locking assembly 200 is coupled to an expandable medical implant, e.g., an expandable septal anchor 310.
  • an expandable medical implant e.g., an expandable septal anchor 310.
  • the locking system 300 includes a catheter and/or tissue anchor as described in U.S. Pat. App. Nos. 17/544,768 and 17/544,696.
  • the locking device 10 or locking assembly 200 is coupled to a catheter or tissue anchor as described in U.S. Pat. App. Nos. 17/544,768 and 17/544,696.
  • Embodiments of the invention are directed to methods for performing a surgical procedure using the locking device, locking assembly or locking system of the disclosure.
  • the method includes: advancing the locking device or locking assembly to a location within a subject; transitioning the locking device or locking assembly to the unlocked position; tensioning a tensioning element traversing the slot; and transitioning the locking device or locking assembly to the locked position.
  • the surgical procedure includes deploying a medical implant, such as a tissue anchor an expandable tissue anchor.
  • the surgical procedure includes deploying a septal wall anchor or expandable septal wall anchor.
  • the surgical procedure includes deploying an anchor system to cardiac tissue.
  • the surgical procedure includes deploying a medical implant, such as a tissue anchor to treat mitral valve regurgitation as described in U.S. Pat. App. Nos. 17/544,768 and 17/544,696.
  • the method is for treating mitral valve regurgitation in a subject by reshaping an atrial heart chamber of the subject.
  • the method includes: advancing the locking device or locking assembly of the disclosure to a first location of the heart within the subject, wherein the locking device or locking assembly is optionally coupled to a delivery catheter and/or an expandable anchor implant; deploying the expandable anchor implant at the first location by tensioning the tensioning element when the locking device or locking assembly is in the unlocked position; transitioning the locking device or locking assembly to the locked position; detaching the catheter from the locking device or locking assembly; deploying a second expandable anchor at a second location of the heart, wherein the first and second expandable anchors are coupled via a bridging element traversing the heart chamber; and tensioning the bridging element to reshape the heart chamber, thereby treating mitral valve regurgitation in the subject.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne des systèmes, des procédés et des dispositifs associés pour verrouiller un élément de tension, tel qu'un élément de pontage, une suture, un fil ou une corde, pendant une intervention médicale, telle que le positionnement d'un implant médical chez un sujet. Les systèmes, les procédés et les dispositifs de la présente invention sont particulièrement utiles pour la pose et le déploiement d'implants cardiaques en vue de remodeler un anneau de valvule cardiaque pour le traitement d'un trouble cardiaque, tel qu'une régurgitation mitrale.
PCT/US2023/029706 2022-08-09 2023-08-08 Dispositif de verrouillage, système et procédé d'utilisation associé WO2024035681A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202263396551P 2022-08-09 2022-08-09
CN202210948160.3 2022-08-09
US63/396,551 2022-08-09
CN202210948160 2022-08-09
CN202210990971.X 2022-08-18
CN202210990971.XA CN115444477A (zh) 2022-08-09 2022-08-18 一种锁定装置及系统

Publications (2)

Publication Number Publication Date
WO2024035681A2 true WO2024035681A2 (fr) 2024-02-15
WO2024035681A3 WO2024035681A3 (fr) 2024-03-21

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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853289C2 (de) * 1978-12-09 1980-12-18 B. Braun Melsungen Ag, 3508 Melsungen Knopf für chirurgische Zwecke
NL2007794C2 (en) * 2011-11-16 2013-05-21 Vereniging Voor Christelijk Hoger Onderwijs Suture device.
US9468527B2 (en) * 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
CA2971839C (fr) * 2014-12-24 2024-04-30 Edwards Lifesciences Corporation Dispositifs de deploiement d'agrafes de suture
US11324496B2 (en) * 2018-02-15 2022-05-10 Vquad Medical LLC Suture clip and suture clip applier
CN115444477A (zh) * 2022-08-09 2022-12-09 上海骊霄医疗技术有限公司 一种锁定装置及系统

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