WO2024029862A1 - Système de radiothérapie à faible dose pour traitement de démence et d'inflammation chronique selon une forme d'émission de faisceau d'énergie photonique - Google Patents

Système de radiothérapie à faible dose pour traitement de démence et d'inflammation chronique selon une forme d'émission de faisceau d'énergie photonique Download PDF

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WO2024029862A1
WO2024029862A1 PCT/KR2023/011102 KR2023011102W WO2024029862A1 WO 2024029862 A1 WO2024029862 A1 WO 2024029862A1 KR 2023011102 W KR2023011102 W KR 2023011102W WO 2024029862 A1 WO2024029862 A1 WO 2024029862A1
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radiation
treatment
low
carbon nanotube
dose
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PCT/KR2023/011102
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English (en)
Korean (ko)
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정원규
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경희대학교 산학협력단
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Priority claimed from KR1020230091275A external-priority patent/KR20240017746A/ko
Application filed by 경희대학교 산학협력단 filed Critical 경희대학교 산학협력단
Publication of WO2024029862A1 publication Critical patent/WO2024029862A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a low-dose radiation therapy system for the treatment of dementia and chronic inflammation according to the form of photon energy beam emission, and more specifically, to a radiation beam from pulsed beam carbon nanotube sources installed around the inner periphery of the radiation gantry.
  • the beam irradiation interval is controlled by the cell damage repair time (DNA repair time) that allows DNA damage repair of normal cells, It relates to a low-dose radiation treatment system for the treatment of dementia and chronic inflammation according to the form of photon energy beam emission, which can minimize cell damage in the treatment area due to radiation exposure and is particularly advantageous for the treatment of chronic inflammation such as dementia, which is sensitive to radiation exposure.
  • therapeutic radiation among the radiation used for medical purposes, is applied to the tumor of a cancer patient and is used to prevent cancer cells from proliferating further, causing the cancer cells to die at the end of their lifespan or to relieve the patient's pain.
  • IMRT Intensity Modulated Radiation Therapy
  • the object of the present invention is to provide a low-dose radiation therapy device that forms a radiation gantry so that therapeutic radiation is irradiated toward the patient's body by installing a plurality of carbon nanotube sources around the inner periphery of a ring-shaped gate, and includes a control unit. After checking the patient's condition and setting the treatment direction using the patient information entered through We provide a low-dose radiation therapy system for the treatment of dementia and chronic inflammation according to the photon energy beam emission type that provides a customized, optimized radiation treatment environment for patients by controlling the size of radiation energy, the angle at which radiation is irradiated, and the radiation dose irradiated. .
  • Another object of the present invention is to control the radiation beam irradiation time (beam on-off time) of the pulsed beam carbon nanotube sources installed around the inner periphery of the radiation gantry and the radiation beam irradiation interval between the carbon nanotube sources,
  • the beam irradiation interval to the cell damage repair time (DNA repair time)
  • DNA repair time which is capable of repairing DNA damage in normal cells
  • cell damage in the treatment area due to radiation exposure can be minimized, and in particular, chronic diseases such as dementia, which are sensitive to radiation exposure, can be minimized.
  • the goal is to provide a low-dose radiation treatment system for the treatment of dementia and chronic inflammation according to the photon energy beam emission type that is advantageous for the treatment of inflammation.
  • Another object of the present invention is to distribute and arrange a plurality of carbon nanotube sources emitting low energy of 120-300 kVp (kilovolt peak) and low-dose radiation of 10-100 Mu/min around the inner periphery of the radiation gantry, and to selectively By using it, a precise radiation treatment plan can be established, allowing customized treatment for the patient, and the risk of radiation exposure can be reduced, making it safe.
  • kVp kilovolt peak
  • Low-dose radiation devices can be used not only to treat skin cancer, but also to treat benign diseases such as keloids, arthritis,
  • the goal is to provide a low-dose radiation therapy system for the treatment of dementia and chronic inflammation according to the photon energy beam emission form that can be used to treat heterotopic bone ossification, psoriasis, atopy, dementia, Parkinson's disease, and animal cancer.
  • a treatment bed on which a patient lies down to receive treatment is formed in the device body, and a plurality of carbon nanotube sources are installed around the inner periphery of a ring-shaped gate in the device body to direct the patient's body.
  • a low-dose radiation therapy device that forms a radiation gantry to irradiate therapeutic radiation;
  • a control unit that checks the patient's condition using the input patient information, sets the treatment direction, and then controls the operation of the low-dose radiation therapy device to perform radiation treatment.
  • Pulsed beam carbon nanotube sources are installed around the inner periphery of the radiation gantry, and the control unit controls the radiation beam irradiation time (beam on-off time) of the carbon nanotube source and the radiation beam irradiation interval between the carbon nanotube sources.
  • Low-dose radiation therapy for the treatment of dementia and chronic inflammation according to the form of photon energy beam emission characterized in that the beam irradiation interval is controlled by a cell damage recovery time (DNA repair time) capable of repairing DNA damage in normal cells.
  • a system may be provided.
  • the radiation beam irradiation time (beam on-off time) can be set to 1 mec 1 minute or less.
  • a plurality of carbon nanotube sources are formed on the inner periphery of the radiation gantry, and the carbon nanotube sources are distributed throughout the radius of the arc, and each can emit a radiation beam toward the concentric center of the arc. .
  • each carbon nanotube source is irradiated with a dose of 0.2Gy at 3-minute intervals. You can set it to be.
  • the plurality of carbon nanotube sources may be sequentially or alternately irradiated with radiation beams.
  • the beam energy irradiated from the radiation gantry may be a pulsed beam energy of 120 to 300 kVp and 3 mA.
  • the low-dose radiation therapy device includes a treatment bed on which the patient receives treatment while lying down; a device body installed to reciprocate the treatment bed in the longitudinal direction; And a ring-shaped gate is formed on the upper side of the device body so that the bed passes through the center of the gate, and a radiation gantry is installed to irradiate therapeutic radiation toward the patient's body from the inner peripheral direction of the gate.
  • a rotation device may be further provided to change the radiation irradiation position by rotating the radiation gantry along the circumference of the patient's body.
  • a plurality of rows of carbon nanotube source arrays may be formed around the inner periphery of the gate of the radiation gantry, and each carbon nanotube source array may be operated alternately.
  • the present invention is provided with a low-dose radiation therapy device that forms a radiation gantry so that therapeutic radiation is irradiated toward the patient's body by installing a plurality of carbon nanotube sources around the inner periphery of a ring-shaped gate, and inputs through a control unit.
  • the radiation treatment is performed by controlling the operation of the low-dose radiation therapy device, so that the radiation energy irradiated from the radiation therapy device according to the patient's individual characteristics and treatment purpose It has the effect of providing a customized, optimized radiation treatment environment for patients by controlling the size, angle at which radiation is irradiated, and radiation dose irradiated.
  • the present invention controls the radiation beam irradiation time (beam on-off time) of the pulsed beam carbon nanotube sources installed around the inner periphery of the radiation gantry and the radiation beam irradiation interval between the carbon nanotube sources,
  • the beam irradiation interval to the cell damage repair time (DNA repair time)
  • DNA repair time which is capable of repairing DNA damage in normal cells
  • cell damage in the treatment area due to radiation exposure can be minimized, and chronic inflammation such as dementia, which is particularly sensitive to radiation exposure, can be achieved. It has a beneficial effect on treatment.
  • the present invention distributes a plurality of carbon nanotube sources emitting low energy of 120-300 kVp (kilovolt peak) and low-dose radiation of 10-100 Mu/min around the inner periphery of the radiation gantry, distributed by band, and uses them selectively. By doing so, it is possible to establish a precise radiation treatment plan and perform customized treatment for the patient. It is also safe because it reduces the risk of radiation exposure. Low-dose radiation devices can be used not only to treat skin cancer, but also to treat benign diseases such as keloids, arthritis, and heterotopic ossification.
  • It can be used to treat heterotopic bone ossification, psoriasis, atopic dermatitis, dementia, Parkinson's disease, animal cancer, acute and chronic pain in the musculoskeletal and spine areas, and intractable chronic inflammation that is difficult to control with medication.
  • FIG. 1 is a block diagram illustrating a low-dose radiation treatment system according to the present invention.
  • Figure 2 is a conceptual diagram illustrating the arrangement structure of the carbon nanotube source of the low-dose radiation treatment device according to the present invention.
  • Figure 3 is a graph showing the progress of concurrent drug treatment and radiation treatment for experimental rats according to the existing method.
  • Figure 4 is a graph showing the progress of parallel treatment for experimental mice according to the low-dose radiation treatment system of the present invention.
  • Figure 5 is a graph comparing the A ⁇ cortex image and the number of plaques per unit area according to the results of radiation treatment of the existing method with the control group.
  • Figure 6 is a graph comparing the A ⁇ cortex image and the number of plaques per unit area according to the results of low-dose radiation treatment of the present invention with the control group.
  • Figure 7 is a graph comparing the relative expression of the radiation treatment results of the existing method with the control group through RT-PCR.
  • Figure 8 is a graph comparing the relative expression of the results of low-dose radiation treatment of the present invention with the control group through RT-PCR.
  • Figure 9 is a perspective view showing a low-dose radiation therapy device according to the present invention.
  • Figure 10 is a front view showing a low-dose radiation therapy device according to the present invention.
  • Figure 11 is a side view showing a low-dose radiation therapy device according to the present invention.
  • FIG. 1 is a block diagram illustrating a low-dose radiation treatment system according to the present invention.
  • the low-dose radiation therapy system largely forms a treatment bed 100 in the device body 200 on which the patient receives treatment while lying down, and the device body 200 has an inner ring-shaped gate.
  • a low-dose radiation therapy device (10) that forms a radiation gantry (300) by installing a plurality of carbon nanotube sources (310) around the periphery so that therapeutic radiation is irradiated toward the patient's body; and a control unit 20 that checks the patient's condition using the input patient information, sets a treatment direction, and then controls the operation of the low-dose radiation treatment device 10 to perform radiation treatment.
  • pulsed beam carbon nanotube sources 310 are installed around the inner periphery of the radiation gantry 300, and the control unit 20 controls the radiation beam irradiation time (beam on) of the carbon nanotube source 310. -off time) and the radiation beam irradiation interval between the carbon nanotube source 310 can be controlled, but the beam irradiation interval can be controlled by a cell damage repair time (DNA repair time) that allows DNA damage repair of normal cells.
  • DNA repair time a cell damage repair time
  • the radiation beam irradiation time can be set to 1 minute or less.
  • the radiation beam irradiation time (beam on off time) can be controlled in units of 1 msec (1/1000th of a second) or less. Additionally, during the radiation beam irradiation time, the carbon nanotube source 310 may be turned on/off in 1 msec (1/1000th of a second) units to irradiate the radiation beam.
  • Figure 2 is a conceptual diagram explaining the arrangement structure of the carbon nanotube source of the low-dose radiation treatment device according to the present invention.
  • the present invention allows a plurality of carbon nanotube sources 310 to be formed on the inner periphery of the radiation gantry 300, and the carbon nanotube sources 310 are distributed and arranged along the arc radius, Each can direct a low-dose radiation beam toward the concentric center of the arc.
  • each carbon nanotube source 310 can be set to irradiate a dose of 0.2 Gy at 3-minute intervals.
  • the beam energy irradiated from the radiation gantry 300 may be a pulsed beam energy of 120 to 300 kVp and 3 mA.
  • the present invention can enable a plurality of carbon nanotube sources 310 to irradiate radiation beams sequentially or alternately.
  • This method can prevent deterioration of the carbon nanotube source 310 and extend its lifespan. , the waiting time until the next radiation can be shortened, shortening the time required for overall treatment, making intensive radiation treatment possible.
  • low dose radiation refers to low intensity radiation and refers to normal radiation close to nature. Large amounts of radiation can harm living organisms, but these small amounts of low-dose radiation actually promote the physiological activities of living organisms, extending lifespan, promoting growth, or lowering the tumor incidence rate. This is called radiation hormesis.
  • Figure 3 is a graph showing the progress of concurrent drug treatment and radiation treatment on experimental rats according to the existing method.
  • Figure 4 is a graph showing the progress of parallel treatment for experimental mice according to the low-dose radiation treatment system of the present invention.
  • Figure 5 is a graph comparing the A ⁇ cortex image and the number of plaques per unit area (mm3) according to the results of radiation treatment of the existing method with the control group
  • Figure 6 is a graph comparing the A ⁇ cortex image and unit area according to the results of low-dose radiation treatment of the present invention ( This is a graph comparing the number of plaques per mm3) with the control group.
  • Figure 5 shows the results of treatment using conventional 6MeV radiation. According to this, compared to the control group (Vehicle) without radiation treatment, the number of plaques per unit area (mm3) was 28:22. You can see that it has not decreased significantly.
  • Figure 6 shows the results of the low-dose radiation treatment of the present invention, that is, the results of treatment using 300 kVp radiation, in which the number of plaques per unit area (mm3) is 140:70 compared to the control group (Vehicle) without radiation treatment. It was seen that it was greatly reduced.
  • Figure 7 is a graph comparing the relative expression of the radiation treatment results of the existing method with the control group through RT-PCR
  • Figure 8 is a graph comparing the relative expression of the results of the low-dose radiation treatment of the present invention with the control group through RT-PCR.
  • RT-PCR_TNF-a and RT-PCR_IL-6 were performed on the results of existing radiotherapy, respectively.
  • the relative expression ratios compared to the control group were 1:1 and 1:0.8, respectively, which is almost a difference in ratio. You can see that it doesn't come out.
  • RT-PCR_TNF-a and RT-PCR_IL-6 were performed on the low-dose radiation treatment results of the present invention, respectively.
  • the relative expression ratios with the control group were 1.2:0.6 and 1:0.1, respectively.
  • a ratio difference of more than two times was seen.
  • Figure 9 is a perspective view showing a low-dose radiation therapy device according to the present invention
  • Figure 10 is a front view showing a low-dose radiation therapy device according to the present invention
  • Figure 11 is a side view showing a low-dose radiation therapy device according to the present invention.
  • the low-dose radiation therapy device 10 largely consists of a bed 100, a device body 200, and a radiation gantry 300.
  • the bed 100 may provide a plank-shaped structure extending in the longitudinal direction so that the patient can receive treatment while lying down. At this time, both ends of the bed 100 are formed into circular round ends, thereby contributing to a patient-friendly design.
  • This bed 100 can be moved back and forth through a sliding operation in the longitudinal direction while the patient is lying down, and allows the patient's treatment area to be located at the center of the ring-shaped radiation gantry 300.
  • a sliding driver 210 is formed.
  • the sliding driving unit 210 is installed on the device body 200 to support the bed 100.
  • the device body 200 is largely composed of a sliding driver 210, a radiation detector 220, and a body case 230.
  • the sliding drive unit 210 is a component installed on the transport path of the bed 100 to support the lower part of the bed 100 so that it can be slidably driven.
  • the sliding drive unit 210 is located at the lower part of the bed 100.
  • a support 211 facing the bed 100 is formed.
  • the support 211 has the shape of a plate extending in the longitudinal direction.
  • the support 211 is supported at both ends by connecting to the upper part of the main case 230.
  • a rail portion 212 for slidingly guiding the bed 100 is formed on the support 211.
  • the rail unit 212 includes a pair of side fixing rails 212a installed on the left and right sides in the longitudinal direction of the support 211, and a rail guide 212b that is coupled to the rail and slides on the side fixing rail 212a. It can be composed of:
  • the bed 100 is coupled to the upper part of the rail guide 212b and is slidably driven together with the rail guide 212b.
  • a driving unit (not shown) that reciprocates the bed 100 in the rail direction may be formed on the support 211.
  • the driving unit may use an actuator such as a motor or hydraulic cylinder as a power source.
  • a radiation detector 220 is formed below the sliding driver 210.
  • the radiation detector 220 is a detection device that detects radiation that has passed through the subject.
  • the signal detected through the radiation detector 220 may be provided as an image or screen through a display device. At this time, the radiation detector 220 may be installed in the main body case 230.
  • the sliding driver 210 and the radiation detector 220 are disposed inside the main case 230 and form the exterior of the device main body.
  • the main body case 230 forms a center 231 where the radiation gantry 300 and the radiation detector 220 are combined, and one end extends in a state floating in the air based on the center 231.
  • a headrest 232 is formed, and an end opposite to the headrest 232 forms a leg support 233 that extends while floating in the air.
  • both ends of the support 211 of the sliding drive unit are coupled to the head rest 232 and the leg rest 233 of the main case 230, respectively.
  • both ends of the main body case 230 coupled with the support 211 can be formed into a circular round shape.
  • This circular round design provides a friendly and soft feeling, contributing to the patient's psychological stability. .
  • the shape of the central portion 231 of the main body case 230 has a shape curved downward in a bow shape.
  • radiation gantries 300 are coupled to both sides of the radiation detector 220.
  • the concept of exposing the internal structure of the device has the advantage of highlighting the simplicity and stability of the device.
  • the interior is exposed, maintenance of the structure is convenient.
  • the lower part of the center 231 can be fixed to the floor of the building using a holder 240.
  • the holder 240 can have electrical equipment, control equipment, and communication equipment for operating the ionizing radiation therapy device installed inside.
  • the device body 200 is equipped with a radiation gantry 300 that irradiates therapeutic radiation to the patient's torso.
  • the radiation gantry 300 forms a ring-shaped gate that surrounds the patient's torso. At this time, a plurality of carbon nanotube sources 310 are formed on the inner periphery of the gate to irradiate therapeutic radiation toward the patient's torso.
  • a plurality of carbon nanotube sources 310 that emit low energy of 120 to 300 kVp (kilovolt peak) and low dose radiation of 10 to 100 Mu/min are placed around the inner periphery of the radiation gantry 300 for each band. It can be distributed and placed.
  • low dose radiation refers to low intensity radiation and refers to normal radiation close to nature. Large amounts of radiation can harm living organisms, but these small amounts of low-dose radiation actually promote the physiological activities of living organisms, extending lifespan, promoting growth, or lowering the tumor incidence rate. This is called radiation hormesis.
  • the treatment bed 100 according to the present invention may be further equipped with a rotation device (not shown) to rotate the patient's body along the inner periphery of the radiation gantry 300.
  • the rotation device (not shown) rotates the patient and the treatment bed 100 in a lying state to change the position of the body part to which the patient's radiation is irradiated, and adjusts the radiation irradiation range and intensity according to the patient's body part. It can be provided as a means for more active control.
  • the carbon nanotube source 310 may be arranged in multiple rows around the inner periphery of the gate of the radiation gantry 300, and each array of carbon nanotube source 310 may be operated alternately.
  • the carbon nanotube sources 310 are arranged in two rows, after the irradiation of the carbon nanotube sources 310 in one row is sequentially performed, the carbon nanotube sources 310 in the first row are in a standby state. , and the radiation treatment of the two rows of carbon nanotube sources 310 waiting for treatment can be sequentially performed to allow radiation treatment to proceed.
  • the treatment time can be shortened and intensive radiation treatment is possible.
  • the present invention selectively controls the carbon nanotube source 310, checks the patient's condition using input patient information, sets the treatment direction, and then controls the operation of the low-dose radiation treatment device 10.
  • a control unit 20 that performs radiation treatment may be provided.
  • a selective treatment mode can be set according to the type of disease and patient condition through the control unit 20.
  • the carbon nanotube source 310 in a specific band among the plurality of carbon nanotube sources 310 divided by band is selectively operated or two or more carbon nanotubes are used.
  • the source 310 can be operated simultaneously to achieve complex treatment.
  • the control unit 20 checks the patient's condition through pre-entered patient information, sets the treatment direction, and then, according to the judgment of the control unit 20, After the treatment bed 100 is driven to position the patient in the optimal treatment position, the radiation gantry 300 is driven to perform radiation therapy.
  • the control unit 20 can be installed on the outer surface of the radiation gantry 300, as shown in FIGS. 9 to 11, so that the operator can conveniently operate and use it.
  • the carbon nanotube source 310 used in the present invention may be a carbon nanotube X-ray source containing a metal emitter and CNTs (carbon nanotubes) growing in the emitter.
  • the CNT carbon nanotube
  • the CNT growth process is a plasma chemical vapor deposition process that supplies hydrocarbon gas ( PECVD (Plasma Enhanced Chemical Vapor Deposition) or Thermal CVD (Thermal Chemical Vapor Deposition) process can be used.
  • PECVD Plasma Chemical Vapor Deposition
  • Thermal CVD Thermal Chemical Vapor Deposition
  • the present invention includes a low-dose radiation therapy device that forms a radiation gantry so that therapeutic radiation is irradiated toward the patient's body by installing a plurality of carbon nanotube sources around the inner periphery of a ring-shaped gate, After checking the patient's condition and setting the treatment direction using the patient information entered through the control unit, the operation of the low-dose radiation therapy device is controlled to perform radiation treatment, so that the radiation therapy device is administered according to the patient's individual characteristics and treatment purpose.
  • the size of the irradiated radiation energy, the angle at which the radiation is irradiated, and the radiation dose irradiated an optimized radiation treatment environment tailored to the patient can be provided.
  • the present invention controls the radiation beam irradiation time (beam on-off time) of the pulsed beam carbon nanotube sources installed around the inner periphery of the radiation gantry and the radiation beam irradiation interval between the carbon nanotube sources,
  • the beam irradiation interval to the cell damage repair time (DNA repair time)
  • DNA repair time which is capable of repairing DNA damage in normal cells
  • cell damage in the treatment area due to radiation exposure can be minimized, and chronic inflammation such as dementia, which is particularly sensitive to radiation exposure, can be achieved. It has advantages in treatment.
  • the present invention distributes a plurality of carbon nanotube sources emitting low energy of 120 to 300 KVP (kilovolt peak) and low dose radiation of 10 to 100 Mu/min around the inner periphery of the radiation gantry, distributed by band, and uses them selectively. By doing so, it is possible to establish a precise radiation treatment plan and perform customized treatment for the patient. It is also safe because it reduces the risk of radiation exposure. Low-dose radiation devices can be used not only to treat skin cancer, but also to treat benign diseases such as keloids, arthritis, and heterotopic ossification.

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Abstract

Selon un aspect de la présente invention, il peut y avoir un système de radiothérapie à faible dose pour le traitement de la démence et d'une inflammation chronique selon une forme d'émission de faisceau d'énergie photonique, le système de radiothérapie à faible dose comprenant : un dispositif de radiothérapie à faible dose qui forme, dans le corps du dispositif, un lit de traitement sur lequel un patient est allongé et reçoit un traitement et qui forme, dans le corps du dispositif, un portique de rayonnement ayant une pluralité de sources de rayonnement de nanotubes de carbone montées sur la surface circonférentielle interne d'une entrée annulaire et rayonnant un rayonnement de traitement vers le corps du patient ; et une unité de commande qui vérifie l'état du patient à l'aide d'informations de patient entrées, définit une direction de traitement, puis commande le fonctionnement du dispositif de radiothérapie à faible dose pour effectuer une radiothérapie, les sources de rayonnement de nanotubes de carbone d'un type de faisceau pulsé étant montées sur la surface circonférentielle interne du portique de rayonnement et l'unité de commande commandant un temps de marche-arrêt de faisceau des sources de rayonnement de nanotubes de carbone et un intervalle de rayonnement de faisceau de rayonnement entre les sources de rayonnement de nanotubes de carbone, l'intervalle de rayonnement de faisceau étant commandé à un temps de réparation d'ADN dans lequel un endommagement d'ADN dans des cellules normales peut être réparé.
PCT/KR2023/011102 2022-08-01 2023-07-31 Système de radiothérapie à faible dose pour traitement de démence et d'inflammation chronique selon une forme d'émission de faisceau d'énergie photonique WO2024029862A1 (fr)

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KR20220095619 2022-08-01
KR10-2022-0095619 2022-08-01
KR10-2023-0091275 2023-07-13
KR1020230091275A KR20240017746A (ko) 2022-08-01 2023-07-13 광자 에너지 준위에 따른 치매, 만성 염증 치료를 위한저선량 방사선 치료시스템

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US20170273643A1 (en) * 2011-01-20 2017-09-28 Accuray Incorporated Radiation Treatment Delivery System with Translatable Ring Gantry
KR20200065477A (ko) * 2018-11-30 2020-06-09 (주)아우라케어 방사선 촬영 및 치료 장치
KR20200114767A (ko) * 2019-03-29 2020-10-07 한국수력원자력 주식회사 저선량방사선에 의한 류마티스 관절염 예방
KR20200134540A (ko) * 2019-05-22 2020-12-02 경희대학교 산학협력단 뇌 이상 단백질 치료를 위한 방사선 치료 시스템 및 이의 치료 방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170273643A1 (en) * 2011-01-20 2017-09-28 Accuray Incorporated Radiation Treatment Delivery System with Translatable Ring Gantry
KR20200065477A (ko) * 2018-11-30 2020-06-09 (주)아우라케어 방사선 촬영 및 치료 장치
KR20200114767A (ko) * 2019-03-29 2020-10-07 한국수력원자력 주식회사 저선량방사선에 의한 류마티스 관절염 예방
KR20200134540A (ko) * 2019-05-22 2020-12-02 경희대학교 산학협력단 뇌 이상 단백질 치료를 위한 방사선 치료 시스템 및 이의 치료 방법

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