WO2024026542A1 - Procédé de quantification de la vélocimétrie doppler dans des vaisseaux sanguins - Google Patents

Procédé de quantification de la vélocimétrie doppler dans des vaisseaux sanguins Download PDF

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Publication number
WO2024026542A1
WO2024026542A1 PCT/BG2022/050004 BG2022050004W WO2024026542A1 WO 2024026542 A1 WO2024026542 A1 WO 2024026542A1 BG 2022050004 W BG2022050004 W BG 2022050004W WO 2024026542 A1 WO2024026542 A1 WO 2024026542A1
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Prior art keywords
doppler
blood vessels
area
modalities
measurement
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PCT/BG2022/050004
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English (en)
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Petar Ignatov
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"Dreamworks Instrument Solutions" Ltd.
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Priority to PCT/BG2022/050004 priority Critical patent/WO2024026542A1/fr
Publication of WO2024026542A1 publication Critical patent/WO2024026542A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0808—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/02—Foetus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography

Definitions

  • the method which is a subject of the present invention, is applicable to all areas of medicine where blood oxidation levels must be monitored and more specifically - in maternal fetal medicine.
  • Doppler velocimetry has been widely used throughout the years as a most valuable tool in the follow-up and prognosis of various pregnancy complications, such as fetal growth restriction, fetal anaemia, as well as twin-to-twin transfusion syndrome in multiple pregnancies (1).
  • middle cerebral artery pulsatility index
  • pulsatility index is a commonly used modality to assess fetal well-being, especially in late FGR.
  • the measurement of middle cerebral artery’s pulsatility index continues to serve as a gold standard for the assessment of fetal brain-sparing.
  • fetal brain Doppler assessment is currently narrowed to monitoring late fetal growth restriction (>32 weeks of gestation), where cerebroplacental ratio and middle cerebral artery Doppler may be of specific clinical value [11,12,13].
  • the so called “dicrotic notch” is a small and brief increase in arterial blood pressure that appears when the aortic valve closes.
  • This landmark has been widely referred to in the descriptive analysis of the arterial waveform (especially of aortic and radial arteries) and is commonly used as an equivalent of end-systolic left ventricular pressure [14,15,16,17],
  • the dicrotic notch is universally associated with aortic valve closure [18], and possibly with changes in the peripheral vascular resistance [19], although to date, no physical mechanism for the existence of the dicrotic notch has been demonstrated convincingly.
  • Doppler velocimetry In middle cerebral artery Doppler velocimetry, it can be used as a marker of the end of systole and beginning of diastole. Visual dicrotic notch representation, as it appears on Pulse wave Doppler, is shown on figure 3.
  • dicrotic notch serving as a readily recognizable marker to indicate the beginning of diastole, it is necessary to appoint a suitable measurement tool to quantify the brain-sparing effect.
  • the systolic area in Pulse wave waveforms is being measured, defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • subject of measurement is the diastolic area in Pulse wave waveforms (or other Doppler modalities), defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • Figure 1 represents the common use of the Doppler measurement of the blood velocity
  • Figure 1 Shown in the image on the left is a PI of 1.74 at 34 weeks of gestation (normal finding).
  • the DN can be used as a demarcation tool to define systole and diastole
  • the DDA shape is defined by DN - dicrotic notch, D - end diastolic velocity and At - (t2 - tl).
  • Method for evaluation of the blood flow, characterized by measurement of areas under the curve of Pulse wave waveforms (or other Doppler modalities) of blood vessels (arteries or veins).
  • the systolic area in Pulse wave waveforms is being measured, defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • subject of measurement is the sdiastolic area in Pulse wave waveforms (or other Doppler modalities), defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • the diastolic deceleration area can be quantified with the following trapezoid area formula:
  • A V2 (a + b) h
  • A area
  • a ” and “b ” are the bases of the trapezoid
  • h is height.
  • Doppler curve quantification provides means for earlier diagnosis of fetal hypoxemia/hypoxia and anaemia, growth restriction, as well as broader spectrum of diagnostic possibilities in twin-to-twin transfusion syndrome and other conditions;
  • Pulse wave Doppler calculation of systolic and diastolic areas in Pulse wave Doppler is applicable in all areas of human and veterinary medicine.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention propose, pour une mesure plus correcte de la vélocité sanguine, un procédé d'évaluation du débit sanguin, comprenant une étape de mesure de la courbe de formes d'ondes (ou d'autres modalités Doppler), dérivées de la vélocimétrie Doppler de vaisseaux sanguins (artères ou veines), caractérisé par la mesure de zones sous ladite courbe de formes d'onde d'ondes de pouls (ou d'autres modalités Doppler). La zone est une zone systolique dans des formes d'onde d'onde de pouls (ou d'autres modalités Doppler), définies par la présence d'une encoche dicrote dans la vélocimétrie Doppler des vaisseaux sanguins. La zone est une zone diastolique dans des formes d'onde d'onde de pouls (ou d'autres modalités Doppler), définies par la présence d'une encoche dicrote dans la vélocimétrie Doppler des vaisseaux sanguins.
PCT/BG2022/050004 2022-08-05 2022-08-05 Procédé de quantification de la vélocimétrie doppler dans des vaisseaux sanguins WO2024026542A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140350405A1 (en) * 2011-11-30 2014-11-27 Koninklijke Philips N.V. System and method for identifying high risk pregnancies
US20180296104A1 (en) * 2017-04-13 2018-10-18 Atcor Medical Pty Ltd Non-invasive blood pressure measurement
US20200090819A1 (en) * 2018-09-14 2020-03-19 Fundacio Institut De Ciencies Fotoniques System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow
US20210401332A1 (en) * 2018-11-15 2021-12-30 My-Vitality Sàrl Self-monitoring and care assistant for achieving glycemic goals

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140350405A1 (en) * 2011-11-30 2014-11-27 Koninklijke Philips N.V. System and method for identifying high risk pregnancies
US20180296104A1 (en) * 2017-04-13 2018-10-18 Atcor Medical Pty Ltd Non-invasive blood pressure measurement
US20200090819A1 (en) * 2018-09-14 2020-03-19 Fundacio Institut De Ciencies Fotoniques System and computer-implemented method for detecting and categorizing pathologies through an analysis of pulsatile blood flow
US20210401332A1 (en) * 2018-11-15 2021-12-30 My-Vitality Sàrl Self-monitoring and care assistant for achieving glycemic goals

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
A.C. GUYTONJ.E. HALL: "Textbook of Medical Physiology", 2006, ELSEVIER INC, pages: 9
BASCHAT AA, GEMBRUCH U: " The cerebroplacental Doppler ratio revisited. Ultrasound", OBSTET GYNECOL, vol. 21, no. 2, February 2003 (2003-02-01), pages 124 - 7
C. C., STAMPALIJA, T., BASCHAT, A., DA SILVA COSTA, F., FERRAZZI, E., FIGUERAS, F., HECHER,K., POON, L. C., SALOMON, L. J., UNTERS: " ISUOG Practice Guidelines:diagnosis and management of small-for-gestational-age fetus and fetal growth restriction", ULTRASOUND IN OBSTETRICS AND GYNECOLOGY, vol. 56, 2020, pages 298 - 312
COHEN E, BAERTS W, VAN BEL F.: "Brain-Sparing in Intrauterine Growth Restriction:Considerations for the Neonatologist", NEONATOLOGY, vol. 108, 2015, pages 269 - 276
DEVORE GR: "The importance of the cerebroplacental ratio in the evaluation of fetal well-being in SGA and AGA fetuses", AM J OBSTET GYNECOL, vol. 213, no. l, July 2015 (2015-07-01), pages 5 - 15
DUNN LSHERRELL HKUMAR S: "Review: Systematic review of the utility of the fetal CPR measured at term for the prediction of adverse perinatal outcome", PLACENTA, vol. 54, 2017, pages 68 - 75, XP085039645, DOI: 10.1016/j.placenta.2017.02.006
F.C. BATTAGLIA ET AL.: "A practical classification of newborn infants by weight and gestational", J PEDIATR, 1967
G. DAHLGREN, F. VEINTEMILLA, G. SETTERGREN, J. LISKA: " Left ventricular end-systolicpressure estimated from measurements in a peripheral artery", CARDIOTHORAC.VASC. ANESTH, vol. 5, no. 6, 1991, pages 551 - 553
GAMRAH, M. AXU, JEL SAWY, AAGUIB, HYACOUB, MPARKER, K. H: "Mechanics of the dicrotic notch: An acceleration hypothesis. Proceedings of the Institution of Mechanical Engineers, Part H", JOURNAL OF ENGINEERING IN MEDICINE, 2020, pages 1253 - 1259, Retrieved from the Internet <URL:https://doi.org/10.!177/0954411920921628>
GORDIJN SJBEUNE IMTHILAGANATHAN BPAPAGEORGHIOU ABASCHAT AABAKER PNSILVER RMWYNIA KGANZEVOORT W: "Consensus definition for placental fetal growth restriction: a Delphi procedure", ULTRASOUND OBSTET GYNECOL, vol. 48, no. 3, 2016, pages 833 - 9
GOSLING RGKING DHNEWMAN DLWOODCOCK JP: "Transcutaneous measurement of arterial blood velocity ultrasound", ULTRASONICS FOR INDUSTRY CONFERENCE PAPERS (GUILDFORD: IPC, 1969, pages 16 - 32
H.L. FALSETTIR.E. MATESR.J. CARROLLR.L. GUPTAA.C. BELL: "Analysis and correction of pressure wave distortion influid-filled catheter systems", CIRCULATION, vol. 49, no. 1, 1974, pages 165 - 172, XP055278646, DOI: 10.1161/01.CIR.49.1.165
J.L. HEBERTY. LECARPENTIERK. ZAMANIC. COIRAULTG. DACCACHED. CHEMLAN. WUILLIEZL. LARSONNEUR: "Relation between aortic dicrotic notch pressure andmean aortic pressure in adults", AM. J. CARDIOL, vol. 76, no. 4, 1995, pages 301 - 306, XP005497327, DOI: 10.1016/S0002-9149(99)80086-1
LEES, C. CSTAMPALIJA, TBASCHAT, A ET AL.: "ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction", ULTRASOUND IN OBSTETRICS AND GYNECOLOGY, vol. 56, 2020, pages 298 - 312, Retrieved from the Internet <URL:hgps:Hdoi.orp-/l0.1002/uog.22134>
MEHER SHERNANDEZ-ANDRADE EBASHEER SNLEES C: "Impact of cerebral redistribution on neurodevelopmental outcome in small-for-gestational-age or growth-restricted babies: a systematic review", ULTRASOUND OBSTET GYNECOL, vol. 46, 2015, pages 398 - 404
MONE FMCAULIFFE FMONG S: "The clinical application of Doppler ultrasound in obstetrics", THE OBSTETRICIAN AND GYNAECOLOGIST, vol. 17, 2015, pages 13 - 19
POLITI, M. T., GHIGO, A., FERNANDEZ, J. M., KHELIFA, I., GAUDRIC, J., FULLANA, J. M., LAGREE, P. Y: "The dicrotic notch analyzed by a numerical model. Computers in", BIOLOGY AND MEDICINE, 2016, pages 54 - 64, XP029511345, Retrieved from the Internet <URL:https://d0i.0rg/l0.1016/j.compbiomed.2016.03.005> DOI: 10.1016/j.compbiomed.2016.03.005
VOLLGRAFF HEIDWEILLER-SCHREURS, C. ADE BOER, M. AHEYMANS, M. WSCHOONMADE, L. JBOSSUYT, P. M. MMOL, B. W. J.DE GROOT, C. J. MBAX, C: "Ultrasound in Obstetrics and Gynecology", vol. 51, 2018, JOHN WILEY AND SONS LTD, article "Prognostic accuracy of cerebroplacental ratio and middle cerebral artery Doppler for adverse perinatal outcome: systematic review and meta-analysis", pages: 313 - 322
WLADIMIROFF JWTONGE HMSTEWART PA: "Doppler ultrasound assessment of cerebral blood flow in the human fetus", BR J OBSTET GYNAECOL, vol. 93, 1986, pages 471 - 475

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