WO2023286746A1 - 接眼光学レンズ、光計測システム、及び光計測方法 - Google Patents
接眼光学レンズ、光計測システム、及び光計測方法 Download PDFInfo
- Publication number
- WO2023286746A1 WO2023286746A1 PCT/JP2022/027306 JP2022027306W WO2023286746A1 WO 2023286746 A1 WO2023286746 A1 WO 2023286746A1 JP 2022027306 W JP2022027306 W JP 2022027306W WO 2023286746 A1 WO2023286746 A1 WO 2023286746A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- optical lens
- base
- recess
- eyepiece optical
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 88
- 238000000034 method Methods 0.000 title claims description 9
- 210000001742 aqueous humor Anatomy 0.000 claims abstract description 37
- 230000002093 peripheral effect Effects 0.000 claims abstract description 13
- 238000005259 measurement Methods 0.000 claims description 38
- 238000001069 Raman spectroscopy Methods 0.000 claims description 33
- 238000000691 measurement method Methods 0.000 claims description 17
- 238000007689 inspection Methods 0.000 claims description 11
- 230000001678 irradiating effect Effects 0.000 claims description 5
- 210000000887 face Anatomy 0.000 claims 2
- 239000000126 substance Substances 0.000 abstract description 6
- 238000004458 analytical method Methods 0.000 abstract description 2
- 210000001508 eye Anatomy 0.000 description 40
- 210000004087 cornea Anatomy 0.000 description 13
- 239000013307 optical fiber Substances 0.000 description 12
- 238000012986 modification Methods 0.000 description 10
- 230000004048 modification Effects 0.000 description 10
- 230000005284 excitation Effects 0.000 description 6
- 239000002207 metabolite Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003786 sclera Anatomy 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 210000000873 fovea centralis Anatomy 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 210000001232 limbus corneae Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
Definitions
- the present invention relates to an eyepiece optical lens, an optical measurement system, and an optical measurement method.
- Patent Documents 1 to 4 disclose techniques for non-invasively examining an eye to be examined.
- light is incident laterally from the nasal side or ear side of the subject's eye, and the aqueous humor is directed in a direction substantially perpendicular to the direction of the eye axis (the line connecting the vertex of the cornea and the fovea centralis) of the subject's eye. permeate along.
- the light passes through the anterior cornea, the aqueous humor, and the posterior cornea of the eye to be examined in this order. It is proposed that this optical path reduces the number of transmitting tissues that are sources of noise and allows concentration measurements of aqueous humor metabolites to be performed. This optical path also prevents light from passing through the pupil and entering the eyeball to damage the retina.
- the present invention has been made in view of the above, and provides an eyepiece optical lens, an optical measurement system, and an optical measurement method that enable non-invasive analysis of substances contained in the aqueous humor of an eye to be examined. It is.
- an eyepiece optical lens provides a base having a plurality of surfaces, a spherical recess forming one surface of the base, and a reflecting portion that forms a surface of the base on the outer peripheral side of the recess and reflects light incident on the base from a surface different from the recess among the plurality of surfaces toward the recess.
- the reflecting portion reflects the light incident on the base portion in a direction substantially orthogonal to the incident direction.
- the reflecting portion reflects the light incident on the base portion in an axial direction passing through the apex of the concave portion.
- the reflecting portion is determined according to the refractive index of a medium forming the eyepiece optical lens, and totally reflects the light incident on the reflecting portion. It is characterized by having a critical angle.
- the reflecting portion forms a surface surrounding the outer periphery of the concave portion of the base portion.
- the reflecting portion forms a surface of the base on the outer peripheral side of the recess, and a surface of the plurality of surfaces, which is different from the recess, extends from the base. and a surface of the base on the outer peripheral side of the recess, and the light reflected by the first reflection portion is reflected by the recess among the plurality of surfaces. and a second reflecting portion that reflects toward a different surface.
- an optical measurement system includes the above eyepiece optical lens, a light source section that irradiates light toward the eyepiece optical lens, and a light receiving section that receives light from the eyepiece optical lens. and an optical measurement device.
- the light receiving unit receives Raman scattered light in the aqueous humor of the eye to be inspected with which the eyepiece optical lens is brought into contact.
- an optical measurement method includes a base having a plurality of surfaces, a concave portion that forms one surface of the base portion and is spherically recessed, and an outer peripheral side of the concave portion of the base portion.
- a light measurement method using an eyepiece optical lens including a reflecting portion that forms a surface and reflects light incident on the base portion from a surface different from the concave portion among the plurality of surfaces toward the concave portion, an adjustment step of irradiating an eye to be inspected with an optical lens in contact with an inspection light and adjusting an incident position of the light so that a spot position of the inspection light is formed on the reflecting portion; and a measurement light irradiation step of irradiating the eyepiece optical lens with measurement light having a large intensity, and a light receiving step of receiving the measurement light.
- the light receiving unit for receiving the measurement light is arranged so that the light intensity of the Raman scattered light in the aqueous humor of the eye to be examined reaches a maximum. It is characterized by including an arranging step of arranging at a position where
- an eyepiece optical lens an optical measurement system, and an optical measurement method that make it possible to noninvasively analyze substances contained in the aqueous humor of an eye to be examined.
- FIG. 1 is a schematic diagram of a Raman scattered light spectroscopic measurement system according to an embodiment of the present invention.
- FIG. 2 is an enlarged view of the eyepiece optical lens.
- FIG. 3 is a partially enlarged view of the light source section.
- FIG. 4 is a flow chart showing the procedure of the Raman spectroscopy measurement method.
- FIG. 5 is an enlarged view of the eyepiece optical lens of Modification 1.
- FIG. 6 is an enlarged view of the light source section of Modification 2.
- FIG. FIG. 7 is an enlarged view of the light source section of Modification 3.
- FIG. 1 is a schematic diagram of a Raman scattered light spectroscopic measurement system according to an embodiment of the present invention.
- An eye 10 to be examined includes a cornea 11 that receives light into the eyeball, an aqueous humor 12 that is positioned inside the cornea 11 and adjusts intraocular pressure, a sclera 13 that is positioned on the outer periphery of the cornea 11, and an inner side of the aqueous humor 12. a located lens 14;
- Aqueous humor 12 contains various metabolites, and it is believed that there is a correlation between these substances and eye diseases. Therefore, a technique for identifying and measuring the concentration of metabolites in the aqueous humor 12 is required.
- the Raman scattered light spectroscopy measurement system 100 performs measurement for analyzing metabolites contained in the aqueous humor 12 by Raman spectroscopy.
- the Raman scattered light spectroscopic measurement system 100 includes an eyepiece optical lens 1 brought into contact with an eye 10 to be inspected, irradiates the eyepiece optical lens 1 with excitation light, and emits light from the aqueous humor 12 of the eye 10 to be inspected. and a Raman scattered light spectrometer 20 for spectrally measuring Raman scattered light.
- the term "contact” refers to a state in which the eyepiece optical lens 1 of the present invention is in contact with the cornea 11, such as “wearing", “wearing”, “adhering", and “contacting”. indicates a state similar to
- FIG. 2 is an enlarged view of the eyepiece optical lens.
- FIG. 2 shows a cross-section of the eyepiece optical lens 1.
- the eyepiece optical lens 1 includes a base portion 1a having a plurality of surfaces, a concave portion 1b forming one surface of the base portion 1a, and an outer peripheral side of the concave portion 1b of the base portion 1a. and an incident portion 1d forming a surface on the opposite side of the concave portion 1b.
- the surface of the base portion 1a on the incident portion 1d side (upper side in FIG. 2) is referred to as the front surface
- the surface of the base portion 1a on the concave portion 1b side lower side in FIG. 2 is referred to as the rear surface.
- the refractive index of the eyepiece optical lens 1 is preferably greater than the refractive index of air (1.00) and greater than the refractive index of the cornea 11 (1.376). In addition, it is preferable that the eyepiece optical lens 1 has hardness to such an extent that the radius of curvature of the base portion 1a does not change when it comes into contact with the cornea 11 . As a material that satisfies these conditions, the eyepiece optical lens 1 is made of, for example, glass or PMMA (Poly Methyl Methylate).
- the concave portion 1b is concave in a spherical shape and has a radius of curvature corresponding to the cornea 11 of the eye 10 to be examined.
- the radius of curvature of the concave portion 1 b is preferably equal to or greater than the radius of curvature of the cornea 11 .
- the reflecting portion 1c (the surface where the reflecting portion 1c- 1 and the reflecting portion 1c- 2 are continuous) is, for example, an interface between glass and air. It has a critical angle for total reflection of light incident on the reflecting portion 1c.
- the reflecting portion 1c is not limited to total reflection as long as it has a sufficiently high reflectance.
- the reflecting portion 1c may be formed by forming a thin film made of metal or the like on the surface of the glass.
- the reflecting portion 1c is formed in an annular shape so as to surround the outer circumference of the recessed portion 1b.
- a cross section including the central axis C1 passing through the apex of the concave portion 1b and passing through the center of the spherical surface formed by the concave portion 1b, as shown in FIG. 2, has the same shape in any direction.
- the vertex of the recess 1b means the most recessed point of the recess 1b.
- the reflecting portion 1c1 reflects the light incident on the base portion 1a from the incident portion 1d toward the central axis C1 in a direction substantially orthogonal to the incident direction.
- the reflecting portion 1c1 may reflect the light incident on the base portion 1a from the incident portion 1d toward the concave portion 1b, and the light reflected by the reflecting portion 1c1 may pass through part of the aqueous humor 12.
- FIG. The angle ⁇ formed by the reflecting portion 1c1 with respect to the lateral direction of the subject's eye 10 (the lateral direction in FIG. 2) is an angle at which light incident from the front is reflected at a substantially right angle to the incident direction, and is, for example, 45°.
- the reflection part The angle ⁇ formed by 1c1 should be set.
- the reflecting portion 1c2 reflects the light reflected by the reflecting portion 1c1 and passing through the aqueous humor 12 toward the incident portion 1d.
- the angle formed by the reflecting portion 1c2 with respect to the lateral direction of the eye 10 to be examined is the angle at which the light from the concave portion 1b is reflected forward, and is, for example, 45°. can be done.
- the incident part 1d preferably has a low reflectance with respect to light from the front, and forms a plane orthogonal to the central axis C1, for example.
- the Raman scattered light spectrometer 20 includes a light source unit 21 for irradiating the eyepiece optical lens 1 with light, an objective lens 22, a condenser lens 23, a notch filter 24, and an optical fiber coupler. 25 , an optical fiber 26 , a spectroscope 27 as a light receiving portion for receiving light from the eyepiece optical lens 1 , and an absorber 28 .
- the Raman scattered light spectrometer 20 measures Raman scattered light scattered in a direction substantially perpendicular to the light introduced into the aqueous humor 12 by the concave portion 1b using incident light emitted from the light source unit 21 as excitation light. This is because the light intensity of Raman scattered light is the same regardless of the direction measured, whereas the light intensity of Rayleigh scattered light is the weakest in the direction substantially orthogonal to the excitation light. This is because it can be measured.
- FIG. 3 is a partially enlarged view of the light source section.
- the light source unit 21 has a light source 211 that irradiates the eye 10 to be examined with light, and a MEMS mirror 212 that can change the reflection direction.
- the light source 211 emits measurement light used as excitation light for spectrally measuring the Raman scattered light in the aqueous humor 12 of the eye 10 to be examined. Also, the light source 211 emits inspection light having a light intensity lower than that of the measurement light. The inspection light is used to inspect whether the light from the light source 211 is applied to the reflecting portion 1c before measurement.
- the wavelengths of measurement light and inspection light are, for example, 532 nm, but are not particularly limited.
- the inspection light preferably has the same wavelength as the measurement light.
- the light source 211 may be any light source that emits light of a predetermined wavelength, such as an LD (Laser Diode).
- the objective lens 22 collects scattered light from the aqueous humor 12 .
- the condensing lens 23 couples the light condensed by the objective lens 22 to the optical fiber coupler 25 .
- the notch filter 24 is a bandstop filter that selectively shields Rayleigh scattered light included in the scattered light from the aqueous humor 12 . Therefore, the notch filter 24 blocks the Rayleigh scattered light contained in the scattered light from the aqueous humor 12 and transmits the Raman scattered light. However, the notch filter 24 selectively shields the light of the same wavelength as the Rayleigh scattered light contained in the scattered light from the aqueous humor 12, and blocks the Raman scattered light contained in the scattered light from the aqueous humor 12. Any filter may be used as long as it is permeable. For example, when Stokes Raman scattering is measured, a filter that transmits longer wavelengths than the excitation light emitted by the light source unit 21 may be used.
- a filter that transmits light having a shorter wavelength than the excitation light emitted by the light source unit 21 may be used.
- a bandpass filter that selectively transmits Raman scattered light may be used.
- the optical fiber coupler 25 couples the light condensed by the condensing lens 23 to the optical fiber 26 .
- the optical fiber 26 introduces scattered light from the aqueous humor 12 to the spectroscope 27 .
- the spectroscope 27 spectroscopically measures the light transmitted through the notch filter 24 . Note that the light condensed by the condensing lens 23 may be directly incident on the spectroscope. In this case, the optical fiber coupler 25 and the optical fiber 26 are unnecessary.
- the absorbent 28 absorbs the light emitted by the light source section 21 .
- FIG. 4 is a flow chart showing the procedure of the Raman spectroscopy measurement method. As shown in FIG. 4, the eyepiece optical lens 1 is brought into contact with the subject's eye 10 (step S1).
- the eye to be inspected 10 with which the eyepiece optical lens 1 is brought into contact is irradiated with inspection light from the light source unit 21 .
- the incident position of the light is adjusted so that the spot position of the inspection light is formed on the reflecting portion 1c1 (step S2: adjustment step).
- the optical path can be estimated according to Snell's law. That is, by adjusting the incident position of the light while checking the position of the spot, the optical path can be adjusted so that the incident light laterally passes through the aqueous humor 12 of the eye 10 to be inspected.
- an optical fiber coupler 25 for introducing light into a spectroscope 27 as a light receiving unit is arranged at a position where the light intensity of Raman scattered light in the aqueous humor 12 of the eye 10 to be examined is maximized (step S3: arrangement step).
- step S4 measurement light irradiation step
- step S5 light receiving step
- FIG. 5 is an enlarged view of the eyepiece optical lens of Modification 1.
- FIG. FIG. 5 shows a cross section of an eyepiece optical lens 1A of Modified Example 1.
- the eyepiece optical lens 1A has a base portion 1Aa having a plurality of surfaces, a concave portion 1Ab forming one surface of the base portion 1Aa, and a concave portion 1Ab of the base portion 1Aa.
- Reflecting portion 1Ac (a surface formed by connecting reflecting portion 1Ac 1 and reflecting portion 1Ac 2 ) forming a surface on the outer peripheral side; 1Ad 1 and the third reflecting portion 1Ad 2 are continuous), and an incident portion 1Ae forming a side surface of the base portion 1Aa.
- the reflecting portion 1Ac and the third reflecting portion 1Ad are formed in an annular shape so as to surround the outer circumference of the recessed portion 1Ab.
- a cross section including the central axis C2 passing through the apex of the concave portion 1Ab and passing through the center of the spherical surface formed by the concave portion 1Ab, as shown in FIG. 5, has the same shape in any direction.
- the reflecting portion 1Ac 1 reflects the light incident from the incident portion 1Ae and reflected by the third reflecting portion 1Ad 1 toward the direction of the central axis C2 in a direction substantially orthogonal to the incident direction. Further, the reflecting portion 1Ac- 2 reflects the light reflected by the reflecting portion 1Ac- 1 toward the third reflecting portion 1Ad- 2 .
- the third reflecting portion 1Ad 1 reflects the light incident on the incident portion 1Ae from the side (nose side or ear side) of the subject's eye 10 in a direction substantially parallel to the central axis C2. Also, the third reflecting portion 1Ad 2 reflects the light reflected by the reflecting portion 1Ac 2 in a direction substantially orthogonal to the central axis C2.
- the configuration may be such that the incident light is introduced from the side of the eye 10 to be examined.
- the reflective portion 1Ac (the surface formed by the reflective portion 1Ac 1 and the reflective portion 1Ac 2 being continuous) and the third reflective portion 1Ad (the surface formed by the reflective portion 1Ad 1 and the third reflective portion 1Ad 2 being continuous)
- the angle, position, size, etc. of the surface it is possible to make the light incident on the aqueous humor 12 easier than when direct incident light is introduced into the aqueous humor 12 from the side.
- FIG. 6 is an enlarged view of the light source section of Modification 2.
- the light source unit 21B includes a light source 211B that irradiates the eye 10 to be inspected with light, a driving unit 212B that drives the light source 211B, and a mirror 213B that reflects the light from the light source 211B toward the eye 10 to be inspected. and have
- the drive unit 212B has a rail extending in a direction perpendicular to the direction in which the light source 211B emits light, and a motor for driving the light source 211B, and is movably held on the rail by driving the motor.
- the light source 211B is moved. When the light source 211B moves on the rail, the position of the light emitted to the eyepiece optical lens 1 can be adjusted.
- FIG. 7 is an enlarged view of the light source section of Modification 3.
- the light source unit 21C includes a light source 211C that irradiates the eye 10 to be examined with light, a lens 212C, and a driving unit 213C that rotates the lens 212C to change the traveling direction of the light transmitted through the lens 212C. and have
- the reflecting portion 1c forms a surface on the outer peripheral side of the concave portion 1b of the base portion 1a. None, and a second reflecting portion that reflects the light reflected by the first reflecting portion toward the incident portion 1d.
- the reflecting portion 1c may have a plurality of reflecting portions spaced apart from each other. In this case, it is preferable to hold the eyepiece optical lens 1 so as not to rotate with respect to the eye 10 to be examined.
- the reflecting portion 1c may have only a reflecting portion that forms the outer peripheral surface of the recessed portion 1b of the base portion 1a and reflects the light incident from the incident portion 1d toward the recessed portion 1b.
- a reflecting portion 1c it is possible to laterally introduce light incident on the eye 10 to be examined 10 into the aqueous humor 12 from the front.
- the light that has passed through the aqueous humor 12 is emitted to the side (nasal side or ear side) of the eye 10 to be examined, so the absorbent 28 may be arranged on the side of the eye 10 to be examined.
- Reference Signs List 1 1A ocular optical lens 1a, 1Aa base 1b, 1Ab concave portion 1c, 1Ac reflecting portion 1d, 1Ae incident portion 1Ad third reflecting portion 10 eye to be examined 11 cornea 12 aqueous humor 13 sclera 14 lens 20 Raman scattered light spectrometer 21 , 21B, 21C light source unit 22 objective lens 23 condenser lens 24 notch filter 25 optical fiber coupler 26 optical fiber 27 spectrometer 28 absorber 100 Raman scattered light spectroscopic measurement system 211, 211B, 211C light source 212 MEMS mirror 212B, 213C drive Part 213B Mirror 212C Lens
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Eye Examination Apparatus (AREA)
Abstract
Description
〔ラマン散乱光分光計測システムの構成〕
図1は、本発明の実施の形態に係るラマン散乱光分光計測システムの模式図である。被検眼10は、眼球に光を取り込む角膜11と、角膜11の内側に位置し、眼圧を調整する房水12と、角膜11の外周に位置する強膜13と、房水12の内側に位置する水晶体14と、を含む。房水12中にはさまざまな代謝産物が含まれており、これらの物質と眼の疾病との間には相関があると考えられている。そのため、房水12内の代謝産物の同定や濃度を計測する技術が求められている。ラマン散乱光分光計測システム100は、房水12に含まれる代謝産物をラマン分光法により分析するための計測を行う。ラマン散乱光分光計測システム100は、図1に示すように、被検眼10に触接させる接眼光学レンズ1と、接眼光学レンズ1に励起光を照射するとともに、被検眼10の房水12からのラマン散乱光を分光計測するラマン散乱光分光計測装置20と、を備える。なお、本発明において、「触接」とは、本発明の接眼光学レンズ1が角膜11に接する状態を指すものであり、「装用」、「装着」、「着接」、「当接」などと同様の状態を示す。
図2は、接眼光学レンズの拡大図である。図2は、接眼光学レンズ1の断面を表し、接眼光学レンズ1は、複数の面を有する基部1aと、基部1aの一つの面をなしている凹部1bと、基部1aの凹部1bの外周側の面をなす反射部1cと、凹部1bの反対側の面をなす入射部1dと、を備える。なお、本明細書において、基部1aの入射部1d側(図2の上方)の面を前面、基部1aの凹部1b側(図2の下方)の面を後面という。
ラマン散乱光分光計測装置20は、図1に示すように、接眼光学レンズ1に光を照射する光源部21と、対物レンズ22と、集光レンズ23と、ノッチフィルタ24と、光ファイバ結合器25と、光ファイバ26と、接眼光学レンズ1からの光を受光する受光部としての分光器27と、吸収材28と、を備える。
次に、ラマン散乱光分光計測システム100による光計測方法であるラマン散乱光分光計測方法について説明する。図4は、ラマン分光計測方法の手順を表すフローチャートである。図4に示すように、被検眼10に接眼光学レンズ1を触接させる(ステップS1)。
(変形例1)
図5は、変形例1の接眼光学レンズの拡大図である。図5は、変形例1の接眼光学レンズ1Aの断面を表し、接眼光学レンズ1Aは、複数の面を有する基部1Aaと、基部1Aaの一つの面をなす凹部1Abと、基部1Aaの凹部1Abの外周側の面をなす反射部1Ac(反射部1Ac1と反射部1Ac2とが連続してなる面)、基部1Aaの反射部1Acに対向する面をなす第3反射部1Ad(第3反射部1Ad1と第3反射部1Ad2とが連続してなる面)と、基部1Aaの側面をなす入射部1Aeと、を備える。反射部1Ac及び第3反射部1Adは、凹部1Abの外周を囲むように、円環状に形成されている。換言すると、図5のような、凹部1Abの頂点を通り、凹部1Abが形成する球面の中心を通る中心軸C2を含む断面は、どの方向においても同一の形状をなす。
図6は、変形例2の光源部の拡大図である。図6に示すように、光源部21Bは、被検眼10に光を照射する光源211Bと、光源211Bを駆動させる駆動部212Bと、光源211Bからの光を被検眼10に向けて反射するミラー213Bと、を有する。
図7は、変形例3の光源部の拡大図である。図7に示すように、光源部21Cは、被検眼10に光を照射する光源211Cと、レンズ212Cと、レンズ212Cを回転させることによりレンズ212Cを透過した光の進行方向を変更する駆動部213Cと、を有する。
1a、1Aa 基部
1b、1Ab 凹部
1c、1Ac 反射部
1d、1Ae 入射部
1Ad 第3反射部
10 被検眼
11 角膜
12 房水
13 強膜
14 水晶体
20 ラマン散乱光分光計測装置
21、21B、21C 光源部
22 対物レンズ
23 集光レンズ
24 ノッチフィルタ
25 光ファイバ結合器
26 光ファイバ
27 分光器
28 吸収材
100 ラマン散乱光分光計測システム
211、211B、211C 光源
212 MEMSミラー
212B、213C 駆動部
213B ミラー
212C レンズ
Claims (10)
- 複数の面を有する基部と、
前記基部の一つの面をなしており、球面状にくぼんだ凹部と、
前記基部の前記凹部の外周側の面をなし、前記複数の面のうち前記凹部と異なる面から前記基部に入射した光を前記凹部に向けて反射する反射部と、
を備えることを特徴とする接眼光学レンズ。 - 前記反射部は、前記基部に入射した光を入射方向と略直交する方向に反射することを特徴とする請求項1に記載の接眼光学レンズ。
- 前記反射部は、前記基部に入射した光を前記凹部の頂点を通る軸方向に反射することを特徴とする請求項1に記載の接眼光学レンズ。
- 前記反射部は、当該接眼光学レンズを形成する媒質の屈折率に応じて定まり、前記反射部に入射した光を全反射する臨界角を有することを特徴とする請求項1に記載の接眼光学レンズ。
- 前記反射部は、前記基部の前記凹部の外周を囲む面をなすことを特徴とする請求項1に記載の接眼光学レンズ。
- 前記反射部は、
前記基部の前記凹部の外周側の面をなし、前記複数の面のうち前記凹部と異なる面から前記基部に入射した光を前記凹部に向けて反射する第1反射部と、
前記基部の前記凹部の外周側の面をなし、前記第1反射部が反射した光を前記複数の面のうち前記凹部と異なる面に向けて反射する第2反射部と、
を有することを特徴とする請求項1に記載の接眼光学レンズ。 - 請求項1に記載の接眼光学レンズと、
前記接眼光学レンズに向けて光を照射する光源部、及び前記接眼光学レンズからの光を受光する受光部を有する光計測装置と、
を備えることを特徴とする光計測システム。 - 前記受光部は、前記接眼光学レンズを接触させた被検眼の房水におけるラマン散乱光を受光することを特徴とする請求項7に記載の光計測システム。
- 複数の面を有する基部と、
前記基部の一つの面をなしており、球面状にくぼんだ凹部と、
前記基部の前記凹部の外周側の面をなし、前記複数の面のうち前記凹部と異なる面から前記基部に入射した光を前記凹部に向けて反射する反射部と、を備える接眼光学レンズを用いる光計測方法であって、
前記接眼光学レンズを触接させた被検眼に検査光を照射し、前記検査光によるスポットの位置が前記反射部に形成されるように光の入射位置を調整する調整ステップと、
前記検査光より光強度が大きい計測光を前記接眼光学レンズに照射する計測光照射ステップと、
前記計測光を受光する受光ステップと、
を含むことを特徴とする光計測方法。 - 前記受光ステップの前に、前記計測光を受光する受光部を、前記被検眼の房水におけるラマン散乱光の光強度が最大となる位置に配置する配置ステップを含むことを特徴とする請求項9に記載の光計測方法。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202280043184.2A CN117500428A (zh) | 2021-07-14 | 2022-07-11 | 接目光学透镜、光测量系统及光测量方法 |
EP22842090.7A EP4338658A1 (en) | 2021-07-14 | 2022-07-11 | Ocular optical lens, light measuring system, and light measuring method |
JP2023534801A JPWO2023286746A1 (ja) | 2021-07-14 | 2022-07-11 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021-116647 | 2021-07-14 | ||
JP2021116647 | 2021-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2023286746A1 true WO2023286746A1 (ja) | 2023-01-19 |
Family
ID=84919403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2022/027306 WO2023286746A1 (ja) | 2021-07-14 | 2022-07-11 | 接眼光学レンズ、光計測システム、及び光計測方法 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP4338658A1 (ja) |
JP (1) | JPWO2023286746A1 (ja) |
CN (1) | CN117500428A (ja) |
WO (1) | WO2023286746A1 (ja) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06503245A (ja) | 1990-12-14 | 1994-04-14 | ジョージア・テック・リサーチ・コーポレーション | 非侵襲性血中グルコース測定系 |
US20080033261A1 (en) * | 2003-05-28 | 2008-02-07 | Zeller Philipp N | Measuring Blood Glucose Concentration |
JP2011083342A (ja) | 2009-10-14 | 2011-04-28 | Kowa Co | 分子組成測定方法及び装置 |
JP2018175760A (ja) | 2017-04-21 | 2018-11-15 | 富士ゼロックス株式会社 | 眼球の光計測装置及び眼球の光計測方法 |
JP2018175481A (ja) | 2017-04-14 | 2018-11-15 | 富士ゼロックス株式会社 | 眼球の光計測装置 |
-
2022
- 2022-07-11 CN CN202280043184.2A patent/CN117500428A/zh active Pending
- 2022-07-11 EP EP22842090.7A patent/EP4338658A1/en active Pending
- 2022-07-11 JP JP2023534801A patent/JPWO2023286746A1/ja active Pending
- 2022-07-11 WO PCT/JP2022/027306 patent/WO2023286746A1/ja active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06503245A (ja) | 1990-12-14 | 1994-04-14 | ジョージア・テック・リサーチ・コーポレーション | 非侵襲性血中グルコース測定系 |
US20080033261A1 (en) * | 2003-05-28 | 2008-02-07 | Zeller Philipp N | Measuring Blood Glucose Concentration |
JP2011083342A (ja) | 2009-10-14 | 2011-04-28 | Kowa Co | 分子組成測定方法及び装置 |
JP2018175481A (ja) | 2017-04-14 | 2018-11-15 | 富士ゼロックス株式会社 | 眼球の光計測装置 |
JP2018175760A (ja) | 2017-04-21 | 2018-11-15 | 富士ゼロックス株式会社 | 眼球の光計測装置及び眼球の光計測方法 |
Non-Patent Citations (2)
Title |
---|
SIDEROUDI THEOHARIA I., NIKOLAOS M. PHARMAKAKIS, GEORGE N. PAPATHEODOROU, GEORGE A. VOYIATZIS: "Non-invasive detection of antibiotics and physiological substances in the aqueous humor by raman spectroscopy", LASERS IN SURGERY AND MEDICINE, vol. 38, no. 7, 30 May 2006 (2006-05-30), pages 695 - 703, XP093024236, DOI: 10.1002/lsm.20360 * |
ZHANG SHUO, ROEL J. ERCKENS, FRANCISCUS H.M. JONGSMA, CARROLL A.B. WEBERS, TOS T.J.M. BERENDSCHOT: "Design and performance of a dark-field probe with confocal raman spectroscopy for ophthalmic application", JOURNAL OF RAMAN SPECTROSCOPY, vol. 52, no. 7, 5 May 2021 (2021-05-05), pages 1371 - 1375, XP093024231, DOI: 10.1002/jrs.6125 * |
Also Published As
Publication number | Publication date |
---|---|
CN117500428A (zh) | 2024-02-02 |
EP4338658A1 (en) | 2024-03-20 |
JPWO2023286746A1 (ja) | 2023-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Shao et al. | Spatially-resolved Brillouin spectroscopy reveals biomechanical abnormalities in mild to advanced keratoconus in vivo | |
US20220054004A1 (en) | Performing a procedure based on monitored properties of biological tissues | |
JP6188225B2 (ja) | 疾患状態を決定するために予測値と測定値とが比較されるように予測値および測定値を表示する方法 | |
AU661026B2 (en) | Measuring molecular change in the ocular lens | |
US7896498B2 (en) | Apparatus and method for optical measurements | |
US8967802B2 (en) | Ophthalmic apparatus | |
EP3838123A1 (en) | Methods and arrangements for obtaining information and providing analysis for biological tissues | |
US20100049057A1 (en) | Imaging of macular pigment distributions | |
CA2323434C (en) | Spectroreflectometric measurement of oxygenation in a patient's eye | |
US5919132A (en) | On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye | |
WO2023286746A1 (ja) | 接眼光学レンズ、光計測システム、及び光計測方法 | |
JP7420476B2 (ja) | 眼科装置、その制御方法、眼科情報処理装置、その制御方法、プログラム、及び記録媒体 | |
US20170360297A1 (en) | Performing a procedure based on monitored properties of biological tissues | |
US9232891B2 (en) | Method and device for high-resolution retinal imaging | |
US20020095257A1 (en) | Method and system for detection by raman measurements of bimolecular markers in the vitreous humor | |
WO2020195199A1 (ja) | コンタクトレンズ、房水ラマン分光計測装置、房水ラマン分光計測システム、及び房水ラマン分光計測方法 | |
RU2326582C1 (ru) | Способ диагностики возрастной катаракты | |
Delori et al. | In vivo technique for autofluorescent lipopigments | |
JP7412170B2 (ja) | 眼科装置、その評価方法、プログラム、及び記録媒体 | |
CN103598871B (zh) | 一种眼科检查装置 | |
JP7513099B2 (ja) | 眼科装置 | |
CN113331782A (zh) | 一种电脑验光仪 | |
March et al. | Non-invasive measurement of corneal hydration | |
US6709109B1 (en) | Differential spectroscopic imaging of the human retina | |
Stachowiak et al. | In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22842090 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2023534801 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2022842090 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 202280043184.2 Country of ref document: CN |
|
ENP | Entry into the national phase |
Ref document number: 2022842090 Country of ref document: EP Effective date: 20231213 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |