WO2023279239A1

WO2023279239A1 - Contact lens having a plurality of function points

Info

Publication number: WO2023279239A1
Application number: PCT/CN2021/104511
Authority: WO
Inventors: 李雅如; 徐宛芸; 李岱萤; 朱柏丞; 赖绪明; 白金淩; 赖秉杉; 陈柏村
Original assignee: 亮点光学股份有限公司; 宝泓生医股份有限公司
Priority date: 2021-07-05
Filing date: 2021-07-05
Publication date: 2023-01-12

Abstract

Disclosed is a contact lens having a plurality of function points. The multi-function point contact lens has a front convex surface and a back concave surface. The multi-function point contact lens comprises an optical region, a function point region, and an edge region; the optical region is located in a central region; the function point region surrounds the periphery of the optical region; the edge region surrounds the periphery of the function point region; the front convex surface or the back concave surface is provided with a plurality of function points distributed in form of mesh points; the plurality of function points have a releasable dosage form and are distributed in the function point region; the function points allow the contained releasable dosage form to be dissolved in the tear as the time of wearing by a user increases.

Description

Contact lenses with multifunctional points

technical field

The invention relates to the technical field of contact lenses, in particular to a contact lens with protective components, releasable components and indicating functions.

Background technique

Contact lenses have been commercially used to improve eyesight since the 1950s. The first generation of contact lenses were made of hard materials, and the wearers were prone to foreign body sensation, poor oxygen permeability, and poor comfort. Later, due to the development of technology, soft contact lenses were produced, with hydrogel as the base material, which made the wearer more comfortable to wear and prolonged the wearing time of the user. As a result, the number of wearers increased and became more popular .

With the continuous evolution of technology, some contact lenses with different functions have appeared. At present, the technical mechanism of such functional contact lenses can be subdivided according to the type and deficiency as follows:

1. Contact lenses made by mixing medicines and monomers: mixing medicines and contact lens monomers, and then performing contact lens production (light curing or heat curing) and high-temperature sterilization of lenses. Degradation or deterioration due to impact, resulting in poor follow-up treatment effect. Secondly, mixing the medicament into the monomer, the medicament is affected by the thickness of the lens, and the release speed of the medicament is different or buried in the lens, which will also cause poor therapeutic effect.

2. Immersion-type drug-releasing contact lenses: soak the contact lenses in the preservation solution containing the medicament, and use the medicament attached to the surface of the contact lens to release the drug when wearing it later, and this problem will cause the concentration of the medicament at the initial stage of wearing higher, followed by a sharp drop.

3. Use laser to perforate the lens to contain medicine: use laser to form holes in the lens, use the holes to increase the concentration of medicine adsorption, and prolong the release time of medicine. However, this method will cause a decrease in the mechanical strength of the lens and affect the physical properties of the lens raw material.

4. Lens release layer: The lens contains a drug release layer, and the release layer is used to release the drug. This method will cause the difference in swelling properties between the lens layer and the drug release layer, resulting in deformation of the lens, thereby affecting the yield.

In order to solve the above problems, the inventors thought of an improved way to provide a multifunctional contact lens with protective components, releasable components, and indicating functions.

Contents of the invention

The main purpose of the present invention is to provide a multifunctional contact lens with protective components, releasable components, and indicating functions. At the same time, it has an indication function and does not affect the physical properties of the contact lens, which is beneficial to production, manufacture and use.

For realizing aforementioned object, the present invention has adopted following technical scheme:

A contact lens with multifunctional points, the multifunctional point contact lens has a front convex surface and a rear concave surface, the multifunctional point contact lens includes an optical zone, a functional point zone, and an edge zone, and the optical zone is located in the central area , the function point area surrounds the periphery of the optical area, the edge area surrounds the periphery of the function point area, the front convex surface or the rear concave surface is provided with a plurality of function points distributed in a network shape, and the plurality of function points have releasable The dosage form is distributed in the function point area, and the function point will dissolve the contained releasable dosage form in tear fluid as the wearing time of the user increases.

As one of the preferred embodiments, the functional point is embedded on the front convex surface, and its surface is exposed to produce the function of releasing the releasable dosage form, and the functional point does not protrude from the front convex surface.

As one of the preferred embodiments, the exposed area of the functional point is 0.0075 mm ² -0.75 mm ² , and the distance between two adjacent functional points is 0.01 mm -0.3 mm.

As one of the preferred embodiments, the area of all the functional points accounts for 20%-50% of the front convex surface.

As one of the preferred embodiments, the multifunctional point protrudes from the rear concave surface, and the height of the functional point protruding from the rear concave surface does not exceed 5 μm.

As one of the preferred implementations, the protruding area of the multifunctional point is 0.0075 mm ² to 0.75 mm ² , and the distance between two adjacent functional points is 0.01 mm to 0.3 mm.

As one of the preferred embodiments, the total area of all the functional points accounts for 20%-50% of the area of the rear concave surface.

As one of the preferred embodiments, the function point is a transparent body.

As one of the preferred embodiments, the functional point has a color.

As one of the preferred embodiments, it further includes a plurality of color sample points, the functional points have a color, each of the functional points is adjacent to at least one of the color sample points, and the functional points and the color sample points are of different colors.

As one of the preferred embodiments, the functional points and the functional points of different color samples are arranged side by side.

As one of the preferred embodiments, the functional points are partially stacked with the functional points of different color samples.

As one of the preferred embodiments, the functional points and the functional points of different color samples are completely stacked together and embedded in the front convex surface, and the surface of the functional points is exposed on the front convex surface.

As one of the preferred embodiments, the function point and the function point of different color samples are completely stacked together and protrude from the back concave surface, the function point is set on the back concave surface, and the color sample point is then set on the back concave surface. The function points.

As one of the preferred implementations, the plurality of functional dots distributed in the functional dot area have different sizes.

As one of the preferred embodiments, the diameter of the plurality of functional points is between 0.03 mm and 0.1 mm.

As one of the preferred embodiments, the size of the functional point near the optical zone is the smallest, and the size of the functional point near the edge zone is smaller but larger than that near the optical zone.

As one of the preferred embodiments, the content of the releasable dosage form accounts for 0.001 to 50 weight percent of the functional point.

As one of the preferred preferred embodiments, the releasable dosage form in the function point includes a hydrophobic component, a hydrophilic component, an amphoteric component or an active component, and the hydrophilic-lipophilic balance (HLB) of the hydrophobic component is value) between 2-8; the hydrophilic component is a polyol or its hydrophilic-lipophilic balance value (HLB value) is between 12-18; the hydrophilic-lipophilic balance value (HLB value) of the amphoteric component is between 8-14; The active ingredients include natural extracts, eye-moisturizing, anti-inflammation, intraocular pressure-lowering, mydriatic drugs.

As one of the preferred preferred embodiments, the preferred value of the hydrophilic-lipophilic balance (HLB value) of the hydrophobic component is between 2-5; the hydrophilic component is a polyhydric alcohol or its hydrophilic The preferred value of the oil balance value (HLB value) is between 13-16; the preferred value of the hydrophilic-lipophilic balance value (HLB value) of the amphoteric component is between 9-12.

Compared with the prior art, the multifunctional contact lens with protective components, releasable components and indicating functions of the present invention has the following specific effects:

1. Many of the functional points of the present invention are distributed in the functional point area, and the functional point area surrounds the periphery of the optical area, which will not affect the main vision correction function of the optical area, maintain the core value of contact lenses, and distribute the Many of the function points in the function point area can protect the ingredients in the points at ordinary times, and many of the function points in the distribution of the function point area can release the ingredients in the function points in the tear flow process, and the eyes can be treated according to the released ingredients. Appropriate protection or treatment, and the distribution of many of the function points in the function point area can produce a change in color appearance after the components in the function point are released along with the tear flow process, so as to achieve the indicated effect, so that the contact lens It has dual effects of vision correction and treatment protection.

2. The component release of the present invention is responsible for many functional points distributed in the functional point area. The functional points distributed in the form of dots are not easy to affect the physical strength of the lens due to the small swelling of the single point area, so it will not affect the physical strength of the lens during production. Yield rate is reduced due to dot-like function points.

3. The function point of the present invention can have a color due to the ingredients contained in the function point itself. With the release of the ingredients, the color will change from thick to light, achieving the effect of color change indication. This method also helps the wearer to follow the contact lens The discoloration of the lens, and then determine the timing of replacing the lens.

4. The present invention can combine the color sample point with the function point to make the color change effect more obvious.

5. The present invention can utilize multiple function points with different sizes, so that the concentration of the components in the eye can reach the set value at the initial stage of contact lens wearing, so as to obtain the desired health care or treatment effect, and then the function points with large sizes will still gradually The ingredients are released smoothly and slowly, and the action time of the ingredients is extended to achieve the effect of several hours or several days, which meets the design requirements.

Description of drawings

FIG. 1 is a schematic partition diagram of the first embodiment of the contact lens with multi-functional points of the present invention.

FIG. 2 is a schematic cross-sectional view of the first embodiment of the contact lens with multi-functional points of the present invention.

FIG. 3 is a front view of the first embodiment of the contact lens with multi-functional points of the present invention.

4 is an enlarged partial cross-sectional view of the first embodiment of the contact lens with multi-functional points of the present invention.

FIG. 5 is a schematic cross-sectional view of a second embodiment of the contact lens with multi-functional points of the present invention.

FIG. 6 is an enlarged partial cross-sectional view of the second embodiment of the contact lens with multi-functional points of the present invention.

7 is a partially enlarged view of a third embodiment of the contact lens with multi-functional points of the present invention.

8 is a schematic diagram of the distribution of functional points and color sample points in the third embodiment of the contact lens with multi-functional points of the present invention.

Fig. 9 is a schematic diagram of the distribution of functional points and color sample points in the fourth embodiment of the contact lens with multi-functional points of the present invention.

10 is a schematic diagram of the distribution of functional points and color sample points in the fifth embodiment of the contact lens with multi-functional points of the present invention.

11 is a schematic diagram of the distribution of functional points and color sample points in the sixth embodiment of the contact lens with multi-functional points of the present invention.

12 is a schematic diagram of the distribution of functional points and color sample points in the seventh embodiment of the contact lens with multi-functional points of the present invention.

13 is a schematic diagram of the distribution of functional points and color sample points in the eighth embodiment of the contact lens with multi-functional points of the present invention.

FIG. 14 is a front view of a ninth embodiment of the contact lens with multifunctional points of the present invention.

15 is an enlarged schematic diagram of radial distribution of multiple functional points of the ninth embodiment of the contact lens with multifunctional points of the present invention.

Description of drawings:

1: contact lenses;

11: front convex surface;

12: Rear concave surface;

13: optical zone;

14: Function point area;

15: marginal area;

16: Function point;

17: color sample point;

R1: inner ring diameter;

R2: Outer ring diameter;

L: Width.

detailed description

The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments and accompanying drawings. It should be noted that when an element is referred to as being "mounted or fixed on" another element, it means that it may be directly on another element or there may be an intervening element. When an element is said to be "connected" to another element, it means that it may be directly connected to the other element or intervening elements may also be present. In the illustrated embodiment, the directions meaning up, down, left, right, front and rear, etc. are relative to explain that the structure and movement of the different components are relative in this case. These representations are pertinent when the components are in the positions shown in the figures. However, if the description of the location of elements changes, these representations are considered to change accordingly.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

As shown in Fig. 1, Fig. 2 and Fig. 3, they are respectively the partition diagram, sectional view and front view of the contact lens of the present invention, the contact lens 1 of the present invention has a front convex surface 11 and a rear concave surface 12, and the contact lens 1 includes a The optical area 13 , a function point area 14 , and an edge area 15 . The optical area 13 is located in the central area, the functional point area 14 surrounds the optical area 13 , and the edge area 15 surrounds the functional point area 14 . The front convex surface 11 is provided with a plurality of function points 16 distributed in the shape of dots, and the plurality of function points 16 are distributed in the area where the function point area 14 is located. Increased dissolution release of the releasable dosage form. In this way, the functional points 16 distributed in a dot shape can release ingredients smoothly and evenly in a timely manner, maintain an average concentration of ingredients in the tears of the eyes, and will not affect the structural characteristics of the contact lens 1 in manufacturing, improving the yield of production .

Then make a detailed description of the structure of the component:

The optical zone 13 located in the central area of the contact lens 1 is the main area for correcting eyesight, which can be spherical, aspherical, hyperboloid, etc. This part is relatively designed according to the need for vision correction. The functional point area 14 is a non-optical correction lens surrounding the optical area 10 , the inner diameter R1 of the functional point area 14 is between 5.0-8.0 mm, and the outer diameter R2 is between 8.5-13.5 mm. The edge area 15 is the outermost part relative to the geometric center of the lens. Generally speaking, the width L of the edge area 15 is about 0.45mm-0.55mm.

The key point of the present invention is that: the front convex surface 11 or the rear concave surface 12 in the area where the functional point area 14 is located is provided with a plurality of functional points 16 distributed in a dot shape. As shown in Figures 1-4, in this embodiment, the functional point 16 is embedded in the front convex surface 11 and exposed on the surface, which helps to release the releasable components, and the functional point 16 does not protrude from the front convex surface 11 surfaces, also reduces the discomfort of eyelid closing or opening. In order not to affect the physical properties of the lens, the exposed area of each functional point 16 is 0.0075 mm ² -0.75 mm ² , and the distance between two adjacent functional points 16 is 0.01 mm -0.3 mm. The total area of all the functional points 16 accounts for 20%-50% of the area of the front convex surface 11 . In this embodiment, the functional point 16 is first coated on the surface of the mold by printing, and then the contact lens material monomer is formed in the mold, and then other follow-up steps, such as photocuring or thermal curing, are used to make contact lenses. In this way, the functional point 15 can be embedded in the front convex surface 11 and exposed on the surface.

As shown in Fig. 5 and Fig. 6, it is a cross-sectional view and a partially enlarged view of the second embodiment of the present invention. The functional points 16 protrude from the surface of the rear concave surface 12, and the height does not exceed 5 μm, which can reduce the discomfort of eyelid closing or opening, and because the plurality of functional points 16 protrude from the rear concave surface 12, they are invisible When the glasses 1 are worn, there is a gap between the posterior convex surface 12 and the surface of the eyeball, which helps tear fluid flow around the plurality of functional points 16 to release components so that the concentration of the components meets the design value. In addition, in order not to affect the physical properties of the lens, each functional point 16 protrudes in an area of 0.0075mm ² -0.75mm ² , and the distance between two adjacent functional points 16 is 0.01mm-0.3mm. The total area of all the functional points 16 accounts for 20%-50% of the area of the rear concave surface 12 . In this embodiment, the functional points 16 are coated on the surface of the rear concave surface 12 by printing after the contact lens is formed alone, so that the formed functional points 16 can protrude from the surface of the rear concave surface 12 .

In addition, the shape of the function point 16 exposed on the front convex surface 11 or protruding from the rear concave surface 12 is a geometric figure, such as a circle, an ellipse, an arc, a polygon, a rectangle, etc., but not limited thereto.

In the above embodiment, the functional point 16 is formed on the surface of the contact lens 1 by printing. The functional point 16 is composed of a releasable dosage form and a non-releasable substance. The releasable dosage form accounts for 0.001 to 0.001% by weight of the functional point 16. 50%. As shown in Table 1 below, non-releasable substances include silicon-based monomers, reactive monomers, reaction initiators, and crosslinkers. Among them, silicon-based monomer accounts for 50-75% by weight of the functional point 16, including: polydimethylsiloxane (Polydimethylsiloxane, PDMS), (3-glycidyloxypropyl) trimethoxysilane [(3- At least one of Glycidyloxypropyl)trimethoxysilane, GPTMS], 3-[tris(trimethylsiloxy)silyl]propyl methacrylate [3-[tris(trimethylsiloxy)silyl]propyl methacrylate, TRIS]. The reactive monomer accounts for 1-15% by weight of the functional point 16, including: 2-hydroxyethyl methacrylate (2-Hydroxyethyl methacrylate, HEMA), N,N-dimethylacrylamide (N,N-dimethylacrylamide, DMA), glycidyl methacrylate (Glycidyl methacrylate, GMA), methyl methacrylate (methyl methacrylate, MAA) at least one. The reaction initiator accounts for 1 to 15% by weight of the functional point 16, including: 2-hydroxy-2-methylpropiophenone (2-Hydroxy-2-methylpropiophenone, trade name: UVC-1173), 1,2'- Bis(2-chlorophenyl)-tetraphenylbiimidazole (2,2'-Bis(2-chlorophenyl)-4,4',5,5'-tetraphenyl-1,2'-biimidazole, trade name:

900), 1-hydroxycyclohexyl phenyl ketone (1-Hydroxycyclohexyl phenyl ketone, trade name: Flecure 184). The cross-linking agent accounts for 1 to 3% by weight of the functional point 16, including trimethylolpropane trimethacrylate (TMPTMA), N,N'-methylenebisacrylamide (N,N'- Methylenebisacrylamide, NMBA).

As shown in Table 2 below, the releasable dosage form includes a hydrophobic ingredient, a hydrophilic ingredient, an amphoteric ingredient or an active ingredient. The hydrophilic-lipophilic balance value (HLB value) of the hydrophobic component is between 2-8, preferably the HLB value is between 2-5, and the hydrophobic component accounts for 0-1% by weight of the releasable dosage form, including: Castor Oil, Soyabean oil, Cottonseed oil, Sweet orange oil, Peanut oil, Arachis oil, Sesame oil, Sunflower oil (Sun flower seed oil), rapeseed oil (Rapeseed oil) at least one. The hydrophilic component is a polyol or its hydrophilic-lipophilic balance (HLB value) is between 12-18, preferably the HLB value is between 13-16, and the hydrophilic component accounts for 10% by weight of the releasable dosage form ~50%, including Glycerol, Ethylene Glycol, Propylene Glycol, Butylene Glycol, Trihydroxybutane, Polyethylene Glycol Cetyl Ether glycol hexadecyl ether, trade name:

58), polyoxyethylene (20) oleyl ether (Polyoxyethylene (20) oleyl ether, trade name:

O20), polyoxyethylene (10) cetyl ether (Polyoxyethylene (10) cetyl ether, trade name:

C10), polyoxyethylene (100) stearyl ether (Polyoxyethylene (100) stearyl ether, trade name:

S100) at least one of them. The hydrophilic-lipophilic balance value (HLB value) of the amphoteric component is between 8-14, and the preferred HLB value is between 9-12. The amphoteric component accounts for 50-90% by weight of the releasable dosage form, including: polyethylene Diol 400 (Polyethylene glycol 400, PEG-400), Tween 40 (Tween-40), Tween 60 (Tween-60), Tween 80 (Tween-80), capryl caproyl macrogol glyceride (Caprylocaproyl Polyoxyl-8glycerides, trade name:

), polyethylene glycol monostearate (Polyethylene glycol monostearate, trade name:

), polyoxyethylene hydrogenated castor oil (35) (trade name:

EL), polyoxyethylene hydrogenated castor oil (40) (PEG-40Hydrogenated Castor Oil, trade name:

RH40), polyoxyethylene hydrogenated castor oil (60) (PEG-60 Hydrogenated Castor Oil, trade name:

RH60). The active ingredients are natural extracts (such as plant extracts, biological extracts), anti-inflammation, eye pressure-lowering, and mydriatic drugs, and the active ingredients account for 0-5% by weight of the releasable dosage form, including: Pilocarpine , Curcumin, Beta-Carotene, Astaxanthin, Cyclosporin A, Brimondine, Latanoprost, Bu At least one of Brinzolamide and Travoprost.

Table 1 is the composition and proportion of function points

Table 2 is a releasable dosage form composition and proportion table

Furthermore, the functional point 16 of the present invention can be a transparent body. Although it is distributed in the functional point area 14, because the transparency and the contact lens 1 itself present the same color, the wearer will have no eye appearance after wearing it. difference. But not limited to this, the function point 16 can also have a color, the color is caused by the components of the releasable dosage form itself, and the color will change from thick to light as the release of its own components decreases, achieving the effect of color change indication. This method also helps the wearer to judge the timing of lens replacement according to the discoloration of the contact lens 1 .

As shown in Figure 7, in order to make the color changing effect more obvious, the present invention further includes a plurality of color sample points 17, each of the function points 16 is next to the color sample point 17, and the function point 16 and the color sample point 17 are different colors , and the color has a complementary color function, so that the color rendering effect of the contact lens 1 is good. Furthermore, the adjacent function point 16 and the color sample point 17 of different colors will achieve a color mixing effect, for example, the function point 16 is yellow, and the color sample point 17 is blue, and the appearance will appear green visually to the naked eye. Afterwards, as the function point 16 gradually releases the releasable dosage form, the color changes from thick to light, and the blue effect of the color point 15 is changed to achieve the dual effects of component release and color change required by the present invention.

The above-mentioned formation method of the functional point 16 and the color sample point 17 can be transferred to the mold by printing in stages during the initial production process, and then the contact lens monomer is formed in the mold, as shown in Figure 8 and Figure 8. As shown in FIG. 9 and FIG. 10 , the functional dots 16 and the color sample dots 17 distributed in a dot shape can be formed on the front convex surface 11 of the contact lens 1 after subsequent processing. The function point 16 and the color sample point 17 have two different frequency colors that are complementary, and the ways of being adjacent to each other are as follows. As shown in FIG. 8 , the function point 16 and the color sample point 17 are adjacently arranged side by side. As shown in FIG. 9 , the functional point 16 and the color sample point 17 are partially stacked, and the surface of the functional point 16 is exposed on the front convex surface 11 . As shown in Figure 10, the function point 16 and the color sample point 17 are completely stacked, and the surface of the function point 16 is exposed on the front convex surface 11. In this way, the initial color development is mainly based on the function point 16 , then when the releasable dosage form is gradually released and the function point becomes lighter, it will be presented in the color of the color sample point 17.

Furthermore, the function points 16 and the color sample points 17 of the present invention can also be distributed on the rear concave surface 12, as shown in Fig. 11, Fig. 12 and Fig. 13. The multi-energy dots 16 and the color sample dots 17 are formed on the rear concave surface 12 in a dot-like distribution, and then processed and shaped to prevent peeling off. The function point 16 and the color sample point 17 have two different frequency colors that are complementary, and the ways of being adjacent to each other are as follows. As shown in FIG. 11 , the function point 16 and the color sample point 17 are adjacently arranged side by side and protrude from the rear concave surface 12 . As shown in FIG. 12 , the function point 16 and the color sample point 17 are partially stacked, and the contact area between the function point 16 and the rear concave surface 12 is larger than the contact area between the color sample point 17 and the rear concave surface 12 . As shown in Figure 13, the function point 16 and the color sample point 17 are completely stacked, the function point 16 is set on the rear concave surface 12, and the color sample point 17 is set on the function point 16. The initial color rendering of the method is mainly based on the function point 16, and the human eye sees the color rendering effect of the function point 16 behind the contact lens 1 body, and then appears in the color of the color sample point 17 after the releasable dosage form fades .

As shown in Figures 14 and 15, they are diagrams of the ninth embodiment of the present invention and a schematic diagram of the radial distribution of function points 16 in this embodiment. In this example, the shape of the function point 16 is mainly changed. The size of the plurality of function points 16 distributed in the function point area 14 is not the same. The size of the function points 16 gradually increases from the inner circle to the outer circle from small to large, and then it is about 3/4 of the radius, which is the largest value, and then gradually decrease. In other words, the size of the functional point 16 near the optical zone 13 is the smallest, and the size of the functional point 16 near the edge region 15 is smaller but larger than that near the optical zone 13. In this embodiment, the smallest diameter of the functional point 16 is is 0.03mm, and the maximum diameter is 0.1mm. The plurality of functional points 16 with different sizes are only distributed on the front convex surface 11 or the rear concave surface 12 . The total area of all the functional points 16 accounts for 30%-40% of the area of the front convex surface 11 or the rear concave surface 12 . In addition, this method is more convenient in production.

The advantage of the design of the above-mentioned embodiment is that it allows the contact lens 1 to dissolve and release a large amount of releasable components by using the dense small-sized functional points 16 and tear fluid at the initial stage of wearing, so that the concentration of the active ingredient in the eye can reach the set value at the initial stage of wearing , so as to achieve the desired health care or treatment effect, and then the large-sized functional point 16 will gradually release the releasable ingredients gradually and slowly, extending the action time of the active ingredients, achieving the effect of several hours or several days, and maintaining good health care or curative effect, and then according to whether the contact lens 1 is discolored, the replacement operation is performed, so that the multifunctional contact lens with protection components, release components, and indicating functions can achieve the purpose of design.

The lenses of the present invention can be made of lens-forming materials suitable for making ophthalmic lenses, including but not limited to eyeglasses, contact lenses, and intraocular lenses. Materials that can be used to make soft contact lenses include, but are not limited to: silicone elastomers, silicon-containing macromers, hydrogels, silicon-containing hydrogels, etc., and combinations thereof. More preferably, the surface is siloxane or contains siloxane functionality, including but not limited to, polydimethylsiloxane macromers, methacryloxypropyl polyalkylsiloxanes and mixtures thereof, Silicone hydrogel or hydrogel.

Based on the above, the multifunctional contact lens with protective components, release components, and indicating functions of the present invention forms the dot-shaped functional points 16 on the front convex surface 11 or the rear concave surface 12 of the contact lens 1, which helps The releasable dosage form is released to the tear fluid evenly and evenly in a timely manner, and the average active ingredient concentration is maintained in the tear fluid of the eye without affecting the structural characteristics of the contact lens 1 during production, thereby improving the yield of production. In addition, the color of the releasable dosage form of the functional point 16 itself can also be used, and the color sample point 17 can be arranged adjacent to the functional point 16. When the releasable dosage form is released, the color will change from thick to light to achieve the desired color changing effect. , which is beneficial to the wearer to identify the timing of contact lens replacement, so that the active ingredients can exert the best health care or treatment effect, which meets the requirements of the patent application.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the scope of the embodiments of the present invention. That is, all equivalent changes and modifications made according to the patent scope of the present invention are covered by the patent scope of the present invention.

Claims

A kind of contact lens with multifunctional point, it is characterized in that, described multifunctional point contact lens has a front convex surface and a rear concave surface, and described multifunctional point contact lens comprises an optical zone, a function point zone, an edge zone , the optical zone is located in the central area, the functional point zone surrounds the periphery of the optical zone, the edge zone surrounds the periphery of the functional point zone, and the front convex surface or the rear concave surface is provided with a mesh point distribution A plurality of function points, the plurality of function points have releasable dosage forms and are distributed in the function point area, and the function points will dissolve the contained releasable dosage forms in tear fluid as the wearing time of the user increases.
The contact lens with a multifunctional point according to claim 1, wherein the functional point is embedded in the front convex surface, and its surface is exposed to produce the function of releasing the releasable dosage form, and the functional point Not protruding from said front convex surface.
The contact lens with multifunctional points according to claim 2, wherein the area of the exposed area of the functional points is 0.0075 mm 2 to 0.75 mm 2 , and the distance between two adjacent functional points is 0.01 mm to 0.3mm.
The contact lens with multifunctional points according to claim 2, wherein the total area of all the functional points accounts for 20%-50% of the area of the front convex surface.
The contact lens with multifunctional points according to claim 1, wherein the multifunctional points protrude from the rear concave surface, and the height of the multifunctional points protruding from the rear concave surface does not exceed 5 μm .
The contact lens with multifunctional points according to claim 5, characterized in that, the protruding area of the multifunctional points is 0.0075 mm 2 to 0.75 mm 2 , and the distance between two adjacent functional points is 0.01 mm ~0.3mm.
According to the contact lens with multifunctional points according to claim 5, the total area of all said functional points accounts for 20%-50% of the area of said rear concave surface.
The contact lens with multifunctional points according to claim 1, wherein the functional points are transparent bodies.
The contact lens with multifunctional points according to claim 1, wherein the functional points are colored.
The contact lens with multifunctional points according to claim 1, further comprising a plurality of color sample points, the functional points have a color, each of the functional points is adjacent to at least one of the color sample points, The function point and the color sample point are of different colors.
The contact lens with multifunctional points according to claim 10, wherein the functional points and the color sample points are arranged side by side.
The contact lens with multifunctional dots according to claim 10, wherein the functional dots and the color sample dots are partially stacked together.
The contact lens with multifunctional points according to claim 10, characterized in that, the functional points and the color sample points are completely stacked together and embedded in the front convex surface, and are exposed by the surface of the functional points on the front convex surface.
The contact lens with multifunctional points according to claim 10, wherein the functional points and the color sample points are completely stacked together and protrude from the rear concave surface, and the functional points are arranged on the On the rear concave surface, the color sample point is set at the multi-function point.
The contact lens with multifunctional points according to claim 1, characterized in that the sizes of the plurality of functional points distributed in the functional point area are different.
The contact lens with multifunctional points according to claim 14, wherein the diameters of the plurality of functional points are between 0.03 mm and 0.1 mm.
The contact lens with multifunctional points according to claim 14, characterized in that, the size of the functional points near the optical zone is the smallest, and the size of the functional points near the edge zone is small but closer to the The optical zone is large.
The contact lens with multifunctional points according to claim 1, wherein the content of the releasable dosage form accounts for 0.001 to 50 weight percent of the functional points.
The contact lens with multifunctional points according to claim 1, wherein the releasable dosage form in the functional points includes hydrophobic components, hydrophilic components, amphoteric components or active components, and the hydrophobic The hydrophilic-lipophilic balance value (HLB value) of the ingredients is between 2-8; the hydrophilic component is a polyol or its hydrophilic-lipophilic balance value (HLB value) is between 12-18; the amphoteric component The hydrophilic-lipophilic balance value (HLB value) is between 8-14; the active ingredients include natural extracts, eye-moisturizing, anti-inflammation, intraocular pressure-lowering, and mydriatic drugs.
The contact lens with multifunctional points according to claim 18, characterized in that, the preferred value of the hydrophilic-lipophilic balance value (HLB value) of the hydrophobic component is between 2-5.
The contact lens with multifunctional points according to claim 18, characterized in that, the hydrophilic component is a polyhydric alcohol or its hydrophilic-lipophilic balance value (HLB value) preferably ranges from 13-16.
The contact lens with multifunctional points according to claim 18, characterized in that, the preferred value of the hydrophilic-lipophilic balance value (HLB value) of the amphoteric component is between 9-12.