WO2023226109A1

WO2023226109A1 - Extracorporeal circulation system of blood purification apparatus, and automatic pre-washing method thereof

Info

Publication number: WO2023226109A1
Application number: PCT/CN2022/099126
Authority: WO
Inventors: 高光勇; 童锦; 陈飞; 李绍林; 谢川
Original assignee: 重庆山外山血液净化技术股份有限公司
Priority date: 2022-05-26
Filing date: 2022-06-16
Publication date: 2023-11-30
Also published as: CN115089790A

Abstract

An extracorporeal circulation system of a blood purification apparatus and an automatic pre-washing method thereof. The extracorporeal circulation system of the blood purification apparatus comprises a dialyzer (10) and an extracorporeal circulation pipeline, the dialyzer (10) being divided into a blood chamber (11) and a dialysate chamber (12) by means of a semipermeable membrane. The dialyzer (10) is further provided with a blood chamber upper end connector (11a) and a blood chamber lower end connector (11b) which are in communication with the blood chamber (11), and a dialysate upper end connector (12a) and a dialysate lower end connector (12b) which are in communication with the dialysate chamber (12). The extracorporeal circulation pipeline comprises a vein pipeline and an artery pipeline, one end of the artery pipeline being connected to the blood chamber upper end connector (11a), and one end of the vein pipeline being connected to the blood chamber lower end connector (11b). The present invention can effectively solve the problems existing in the prior art, and simplify the operation steps for preparing dialysis treatment to the maximum extent, so that the probability of mis-operation is reduced, and the operation intensity of medical staffs is also reduced.

Description

A blood purification equipment extracorporeal circulation system and its automatic preflushing method

Technical field

The present invention relates to the technical field of blood purification, and in particular to an extracorporeal circulation system of blood purification equipment and an automatic preflushing method thereof.

Background technique

The dialyzer for blood purification treatment is composed of multiple hollow fiber membranes, a shell and an end cap. The hollow fiber membrane divides the dialyzer into two chambers. The inside of the hollow fiber membrane is the blood chamber, and the space between the hollow fiber membrane and the shell is Dialysate chamber. The hollow fiber membrane is a semipermeable membrane with countless tiny pores on it. Small and medium molecule substances can pass through these pores, but large molecular substances such as blood cells cannot pass through these pores. During the blood purification treatment process, the patient's arterial blood is introduced into the dialyzer composed of the above-mentioned hollow fiber membrane, and the blood in the blood chamber and the dialysate in the dialysate chamber exchange materials through diffusion/convection in the dialyzer, and are cleared Metabolic wastes and excess water in the body are removed from the patient's blood, and electrolytes and acid-base balance are maintained. The purified blood is then returned to the body through the veins to achieve the purpose of blood purification in the body.

Extracorporeal circulation lines and dialyzers used in blood purification treatments are generally disposable consumables. To facilitate sterilization, transportation and storage, the lines and dialyzers are usually packaged under dry conditions. Therefore, before starting treatment, it is necessary to pre-flush the extracorporeal circulation pipeline and dialyzer with normal saline or dialysate generated online by hemodialysis equipment in order to eliminate the air in the pipeline and dialyzer and avoid residual air. During treatment, it may enter the human body and form air embolism, thereby endangering the patient's life. It can also prevent micro-bubbles from adhering to the hollow fiber membrane of the dialyzer and causing coagulation in the dialyzer.

The current pre-flush method before blood purification treatment is: install the pump tube of the arterial line of the extracorporeal circulation line into the blood pump, connect one end of the arterial line to the physiological saline or dialysate port, and connect the other end to the dialyzer At the arterial end, connect both ends of the venous line of the extracorporeal circulation line to the venous end of the dialyzer and the waste bag respectively, start the blood pump, set the flow rate to 80-100ml/min, and allow the normal saline to flow through the dialyzer, venous end. The blood pump speed at this time should not be too fast, otherwise it will affect the exhaust effect of the pipeline and dialyzer. In order to facilitate the removal of gases in the dialysis pipeline and the blood chamber (in the membrane) of the dialyzer, the dialyzer is connected to the arterial pipeline at this time. The part should be facing downwards. During the pre-flushing process of the dialyzer blood chamber, it is necessary to tap the dialyzer and adjust the liquid level of the arteriovenous pot manually or through a liquid level adjustment pump to ensure that the gas in the hollow fiber membrane of the dialyzer and in the pipeline is sufficient. Drain. Because the liquid inside and outside the dialyzer membrane needs to form convection, the dialyzer needs to be turned over so that the part connecting the dialyzer and the arterial pipeline faces upwards so that the gas in the dialysate chamber (outside the membrane) of the dialyzer can be drained. After the pre-flushing of the dialysate chamber of the dialyzer is completed, the arterial end and the venous end of the extracorporeal circulation pipeline need to be short-circuited for closed circulation pre-flushing. At this time, a certain ultrafiltration volume needs to be set in the dialysis machine parameters so that the liquid can pass through the dialyzer. Ultrafiltration is carried out from the inside of the hollow fiber membrane of the dialyzer to the outside of the membrane for transmembrane flushing, and at the same time, the gas in the dialyzer and pipelines is further discharged. At this point, the flushing process is completed. In the above preflush process, it is necessary to manually adjust the blood pump flow rate, flip the dialyzer, adjust the arterial and venous pot liquid levels, and set various parameters according to different preflush stages. The overall operation is relatively cumbersome, and the entire preflush process takes ten minutes. The above, and the operator cannot leave the equipment during this process. Therefore, the pre-flush process of dialysis preparation is the busiest time in the dialysis room. The operation of the medical staff is very labor-intensive and is often prone to misoperation, such as This may lead to insufficient pre-flushing or membrane rupture of the dialyzer, affecting the therapeutic effect and causing unnecessary losses.

Contents of the invention

In order to solve the above technical problems, the purpose of the present invention is to provide an extracorporeal circulation system of blood purification equipment and its automatic preflush method, which can effectively solve the problems existing in the existing technology and simplify the operation steps of dialysis treatment preparation to the greatest extent. , reduce the chance of misoperation and reduce the labor intensity of medical staff.

In order to achieve the above technical effects, the present invention adopts the following technical solutions:

In a first aspect, the invention provides a blood purification equipment extracorporeal circulation system, including:

Dialyzer, the dialyzer is divided into a blood chamber and a dialysate chamber by a semipermeable membrane, and is also provided with an upper end interface of the blood chamber and a lower end interface of the blood chamber, and a dialysis interface connected to the dialysate chamber. Liquid upper end interface and dialysate lower end interface, wherein the blood chamber upper end interface is higher than the blood chamber lower end interface, and the dialysate upper end interface is higher than the dialysate lower end interface;

and an extracorporeal circulation pipeline, the extracorporeal circulation pipeline includes a venous pipeline and an arterial pipeline, one end of the arterial pipeline is connected to the upper end interface of the blood chamber, and one end of the venous pipeline is connected to the blood chamber Lower interface.

Further, a peristaltic pump is provided on the arterial pipeline.

Further, an air monitor is provided on the intravenous pipeline.

Further, an arterial pot is connected in series to the arterial pipeline, and a venous pot is connected in series to the venous pipeline, and the arterial pot and the venous pot are respectively provided with an arterial pressure monitoring component and a venous pressure monitoring component.

Further, the tops of the arterial pot and the venous pot are provided with openings, and a pressure monitoring tube is connected to the opening. A pressure monitor is provided at the end of the pressure monitoring tube, and the pressure monitor is used to monitor the artery. The pressure in the pot or intravenous pot is also provided with a water blocking component upstream of the pressure monitor.

Further, the water blocking component includes an outer shell and a gas channel formed inside the outer shell. One end of the outer shell can be connected to the arterial pot or the venous pot, and the other end of the outer shell can be connected to The pressure monitoring tube, the gas channel is used to connect the pressure monitoring tube and the venous pot or arterial pot, the water blocking component is also provided with a water blocking film in the gas channel, and the water blocking film can provide Gas passes through.

Further, the venous pipeline includes a first venous section located upstream of the venous pipeline and a second venous section located downstream of the venous pipeline and used to connect the intravenous pot and the dialyzer. The first vein One end of the segment is connected to the bottom end of the venous pot, and one end of the second venous segment penetrates the venous pot from the top of the venous pot and partially extends to the inside of the venous pot;

Furthermore, one end of the second vein segment located in the venous pot is between 1/2-4/5 of the height of the venous pot.

Further, the arterial line includes a first arterial segment located upstream of the arterial line and used to communicate with the dialyzer and the arterial pot, and a second arterial segment located downstream of the arterial line. The first artery One end of the segment is connected to the bottom end of the venous kettle, and one end of the second arterial segment penetrates the venous kettle from the top of the venous kettle and partially extends to the inside of the arterial kettle;

Furthermore, one end of the second artery segment located in the arterial pot is between 1/2-4/5 of the height of the venous pot.

Further, it also includes a blood chamber liquid supply unit and a dialysate liquid supply unit. The blood chamber liquid supply unit is located at the end of the venous pipeline and provides the first preflush fluid for the extracorporeal circulation system. The dialysis fluid supply unit The output end of the liquid supply unit is connected to the lower end interface of the dialysate and provides the second preflush liquid for the extracorporeal circulation system.

Further, a waste liquid recovery unit is included, which is connected to the extracorporeal circulation pipeline and the dialyzer and is used to collect the first priming fluid and the second priming fluid flowing through the extracorporeal circulation system.

Further, the waste liquid recovery unit includes a first waste liquid collector and a second waste liquid collector, the first waste liquid collector is located at the end of the arterial pipeline and communicates with the arterial pipeline, The second waste liquid collector is connected to the upper end interface of the dialysate.

In a second aspect, the present invention also provides an automatic preflush method for the extracorporeal circulation system of blood purification equipment, which is characterized in that it includes the following steps:

S1: Construct a first pre-flush channel and a second pre-flush channel, and connect the blood chamber supply unit and dialysate supply unit to the head ends of the first pre-flush channel and the second pre-flush channel respectively, Connect the waste liquid recovery unit to the ends of the first pre-flush passage and the second pre-flush passage;

S2: Pre-flushing the first pre-flushing passage:

Control the blood chamber liquid supply unit to provide the first pre-flush liquid to the first pre-flush channel, and make the first pre-flush liquid flow along the first pre-flush channel and finally be enriched in the waste liquid recycling unit;

S3: Pre-flushing the second pre-flushing passage:

Control the dialysate supply unit to provide a second preflush fluid to the second preflush passage, and cause the second preflush fluid to flow along the second preflush passage and finally be enriched to the waste liquid recovery unit;

Among them, the order of steps S2 and S3 can be exchanged or performed simultaneously.

Further, the first pre-fluid is either sterile physiological saline or dialysate, and the dialysate is dialysate that has been sterile filtered at least once.

Further, the second pre-flush solution is any one of physiological saline, sterile physiological saline or dialysate;

Further, the construction method of the first pre-flushing channel and the second pre-flushing channel is specifically:

Connect the venous pot in series to the venous line and connect one end of the venous line to the lower end interface of the blood chamber. Connect the venous pot in series to the arterial line and connect one end of the arterial line. to the upper end interface of the blood chamber. At this time, the venous pot, the lower end interface of the blood chamber, the blood chamber, the upper end interface of the blood chamber, and the arterial pot form a first preflush passage. The lower end interface of the dialysate, the dialysate chamber, and the dialysate The liquid upper end interface forms a second pre-flush passage.

Further, the S2 is specifically: controlling the blood chamber liquid supply unit to provide the first pre-flush liquid to the first pre-flush passage, and causing the first pre-flush liquid to enter the first pre-flush at a first flow rate. channel until the first pre-flush channel is completely filled, and then the first pre-flush liquid flows in the first pre-flush channel at a second flow rate, and is finally enriched to the waste liquid recovery unit, wherein, the The second flow rate is greater than the first flow rate.

Further, the first flow rate is 80-100ml/min, and the second flow rate is 200-300ml/min.

Compared with the prior art, the beneficial effects of the present invention are:

The invention provides an extracorporeal circulation system of blood purification equipment. The extracorporeal circulation system of blood purification equipment includes a dialyzer and an extracorporeal circulation pipeline. The dialyzer is divided into a blood chamber and a dialysate chamber through a semipermeable membrane, and the dialyzer has At the same time, there are an upper end interface of the blood chamber and a lower end interface of the blood chamber connected to the blood chamber, and an upper end interface of the dialysate and a lower end interface of the dialysate connected to the dialysate chamber; the extracorporeal circulation pipeline includes a venous pipeline and an arterial pipeline. Wherein, one end of the arterial line is connected to the upper end interface of the blood chamber, and one end of the venous line is connected to the lower end interface of the blood chamber. At the same time, the present invention also provides an automatic pre-flushing method for the extracorporeal circulation system of blood purification equipment. When using this method to pre-flush the above-mentioned extracorporeal circulation system of blood purification equipment, the pre-flush liquid enters the blood of the dialyzer from the venous pipeline. chamber, and finally flows into the arterial pipeline, thereby achieving the purpose of effective and automatic flushing of the extracorporeal circulation system of the blood purification equipment. The preflushing effect is good, and the flushing process can be automatically controlled, which can simplify the preparation for dialysis treatment to the greatest extent. The operation steps reduce the chance of misoperation, reduce the labor intensity of medical staff, and reduce the manpower requirements of the hospital's dialysis room.

Description of the drawings

Figure 1 is a schematic diagram of the overall structure of Embodiment 1 of the present invention;

Figure 2 is a schematic diagram of the overall structure of Embodiment 2 and Embodiment 3 of the present invention;

The reference numbers are: 10, dialyzer, 11, blood chamber, 11a, upper end interface of blood chamber, 11b, lower end interface of blood chamber, 12, dialysate chamber, 12a, upper end interface of dialysate, 12b, lower end interface of dialysate, 21 , arterial pot, 21a, first arterial segment, 21b, second arterial segment, 22, venous pot, 22a, first venous segment, 22b, second venous segment, 23, peristaltic pump, 24, air monitor, 31, Pressure monitoring tube, 32, pressure monitor, 33, water blocking membrane, 41, blood chamber liquid supply unit, 42, dialysate liquid supply unit, 51, first waste liquid collector, 52, second waste liquid collector.

Detailed ways

The embodiments of the technical solution of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and are therefore only examples and cannot be used to limit the scope of the present invention.

Unless otherwise specified, in the present invention, if there are terms such as "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", The orientation or positional relationship indicated by "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. The orientation or positional relationship shown in the drawings is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore this The terms used to describe the orientation or positional relationship in the invention are only for illustrative purposes and should not be construed as limitations to this patent. Those of ordinary skill in the art can understand the specific meanings of the above terms in conjunction with the accompanying drawings and according to specific circumstances.

It should be noted that in the present invention, the terms "upstream" and "downstream" refer to the direction of fluid flow, "upstream" refers to the direction from which the fluid flows, and "downstream" refers to the direction to which the fluid flows. The "fluid flow direction" here refers to the direction of flow from the venous line to the arterial line.

Example 1

Please refer to Figure 1. The following is a first embodiment of the present invention. This embodiment provides an extracorporeal circulation system of blood purification equipment, which can be used for hemodialysis treatment. Specifically:

An extracorporeal circulation system of blood purification equipment provided in this embodiment includes a dialyzer 10 and an extracorporeal circulation pipeline. The dialyzer 10 is divided into a blood chamber 11 and a dialysate chamber 12 through a semipermeable membrane. The dialyzer 10 There is also an upper blood chamber interface 11a and a lower blood chamber interface 11b connected to the blood chamber 11, and an upper dialysate interface 12a and a lower dialysate interface 12b connected to the dialysate chamber 12, and the blood chamber The upper end interface 11a is higher than the blood chamber lower end interface 11b, and the dialysate upper end interface 12a is higher than the dialysate lower end interface 12b. The extracorporeal circulation line includes a venous line and an arterial line. The venous line includes a first venous segment 22a, a venous pot 22 and a second venous segment 22b. The arterial line includes a first arterial segment. 21a, arterial pot 21 and second arterial segment 21b, wherein the first venous segment 22a is located upstream of the second venous segment 22b, the first arterial segment 21a is located upstream of the second arterial segment 21b, and the extracorporeal circulation line The connection method with dialyzer 10 is as follows:

The end of the first venous section 22a is connected to the bottom end of the venous pot 22, and the second venous section 22b is used to connect the venous pot 22 and the dialyzer 10. Specifically, the second venous section 22b The head end of the second vein section 22b passes through the vein pot 22 from the top of the vein pot 22 and extends into the vein pot 22, and the height of the head end of the second vein section 22b is about 2/3 of the height of the vein pot 22, The end of the second vein segment 22b is connected to the lower end interface 11b of the blood chamber of the dialyzer 10 . The first end of the first artery segment 21a is connected to the upper end interface 11a of the blood chamber of the dialyzer 10, the end of the first artery segment 21a is connected to the bottom end of the arterial pot 21, and the end of the second artery segment 21b is The head end penetrates the venous pot 22 from the top end of the venous pot 22 and extends to the inside of the arterial pot 21 and is located at about 2/3 of the height of the arterial pot 21 .

In the treatment mode of the extracorporeal circulation system of the blood purification equipment provided by this embodiment, the liquid flow direction in the extracorporeal circulation system of the blood purification equipment is: by introducing the patient's blood from the end of the second artery segment 21b into the arterial pipeline and allowing it to flow Flows through the blood chamber 11 of the dialyzer 10, and exchanges substances through diffusion/convection in the dialyzer 10 to remove metabolic waste and excess body water from the patient's blood, and maintain electrolyte and acid-base balance to maintain the balance of the blood. To achieve a purification effect, after the purification is completed, the purified blood is introduced into the venous pipeline through the second venous segment 22b and finally returned to the patient's body through the first venous segment 22a.

In this embodiment, the arterial pressure monitoring assembly and the venous pressure monitoring assembly are respectively provided on the arterial pot 21 and the venous pot 22. The arterial pressure monitoring assembly and the venous pressure monitoring assembly are respectively used to monitor the arterial pipeline and venous line. The pressure in the pipeline is monitored to ensure normal flow of fluid in the extracorporeal circulation system of the blood purification device in treatment mode and priming mode, specifically, the pressure in the arterial pipeline and venous pipeline For monitoring, the tops of the arterial pot 21 and the venous pot 22 are both provided with openings, and the openings are connected to a pressure monitoring tube 31. The end of the pressure monitoring tube 31 is provided with a pressure monitor 32. The pressure monitor 32 is used to monitor the pressure in the arterial pot 21 or the venous pot 22. At the same time, a water blocking component is provided upstream of the pressure monitor 32. Specifically, the water blocking component includes an outer shell and a gas channel formed inside the outer shell. One end of the outer shell can be connected to the arterial pot 21 or the venous pot 22 , and the other end of the outer shell can be connected to the arterial pot 21 or the venous pot 22 . Connected to the pressure monitoring tube 31, the gas channel is used to connect the pressure monitoring tube 31 and the venous pot 21 or the arterial pot 22, so as to detect the pressure in the venous pot 21 or the arterial pot 22, and the water blocking The component is also provided with a water-blocking film 33 in the gas channel. The water-blocking film 33 is made of non-hydrophilic material and allows gas to pass through, so as to prevent the liquid in the arterial pot 21 or venous pot 22 from penetrating the The water-blocking film 33 further enters the pressure monitoring tube 31 and causes cross-infection.

In this embodiment, a peristaltic pump 23 is provided on the arterial pipeline. In both the treatment mode and the pre-flush mode, the peristaltic pump 23 is used to push the liquid in the extracorporeal circulation system to flow in the extracorporeal circulation system. At the same time, the first venous segment 22a of the venous pipeline is also provided with an air monitor 24. In the treatment mode, the setting of the air monitor 24 can ensure that there is no air in the blood returned to the patient's body through the first venous segment 22a. Contains air.

In this embodiment, the extracorporeal circulation system of the blood purification equipment also includes a controller, and the peristaltic pump 23 and the air monitor 24 are both electrically or signally connected to the controller, so that in the treatment mode or the pre-flush mode The liquid flow rate in the extracorporeal circulation system of the blood purification equipment is controlled. At the same time, the air monitor 24 monitors whether the first venous segment 22a contains air in real time, and feeds back the monitoring results to the controller in real time. , so that the operator can promptly adjust the working status of the extracorporeal circulation system of the blood purification equipment during the treatment process or pre-flushing process.

Example 2

Please refer to Figure 2. The following is a second embodiment of the present invention. This embodiment provides an extracorporeal circulation system of blood purification equipment that can perform automatic preflushing. Specifically, the extracorporeal circulation system of blood purification equipment that can perform automatic preflushing On the basis of the extracorporeal circulation system of the blood purification equipment provided in the embodiment, it further includes: a blood chamber 11 liquid supply unit, a dialysate liquid supply unit 42 and a waste liquid recovery unit.

In this embodiment, the blood chamber 11 liquid supply unit is connected to the upstream of the first venous segment 22a and provides the first preflush fluid for the extracorporeal circulation system, and the dialysate liquid supply unit 42 is located on the The dialysate is upstream of the lower end interface 12b and provides the second priming fluid for the extracorporeal circulation system. The waste liquid recovery unit includes a first waste liquid collector 51 and a second waste liquid collector 52, wherein the first waste liquid collector 51 is disposed at the end of the second arterial pipeline and connected with the artery. The pipelines are connected, and the second waste liquid collector 52 is located downstream of the upper dialysate interface 12a and communicates with the upper dialysate interface 12a. At this time, a first pre-flush channel and a second pre-flush channel are formed in the extracorporeal circulation system of the blood purification equipment capable of automatic pre-flush. The first pre-flush channel passes through the interconnected first venous segment 22a, venous pot, etc. 22. The second venous segment 22b, the blood chamber lower end interface 11b, the blood chamber 11, the blood chamber upper end interface 11a, the first arterial segment 21a, the arterial pot 21 and the second arterial segment 21b, and the first end of the first pre-flush channel It is also connected to the blood chamber 11 liquid supply unit, and the end is connected to the first waste liquid collector 51; and the second pre-flush passage passes through the interconnected dialysate lower end interface 12b, dialysate chamber 12 and dialysate upper end interface 12a in sequence, Moreover, the head end of the second pre-flush passage is also connected to the dialysate supply unit 42, and the end end is connected to the second waste liquid collector 52.

In the priming mode, the blood chamber 11 liquid supply unit inputs the first priming fluid into the first priming passage, and the first priming fluid flows along the first priming passage to achieve the purpose of priming the first priming passage. A pre-flush channel performs the purpose of pre-flush, and the pre-flush of the second pre-flush channel is to input the second pre-flush liquid into the second pre-flush channel through the dialysate supply unit 42 and make the second pre-flush The flushing liquid flows along the second pre-flushing passage. Finally, the first pre-flushing liquid flowing through the first pre-flushing passage is collected by the first waste liquid collector 51, and the second pre-flushing liquid flowing through the second pre-flushing passage is collected. The priming liquid is collected through the second waste liquid collector 52 . Optionally, the second waste liquid collector 52 and the first waste liquid collector 51 can also be connected through a waste liquid transport pipeline to collect all the waste generated by the extracorporeal circulation system of the blood purification equipment in the pre-flush mode. Liquid is enriched.

Example 3

Please refer to Figure 2. The following is a third embodiment of the present invention. This embodiment provides an extracorporeal circulation system for blood purification equipment and an automatic preflush method thereof. The method specifically includes the following steps:

In this embodiment, the output end of the controller of the extracorporeal circulation system of the blood purification equipment is also connected to a first prompter and a second prompter, and the first prompter and the second prompter respectively correspond to the first abnormal state. and a second abnormal state.

In this embodiment, the automatic preflushing method of the extracorporeal circulation system of the blood purification equipment specifically includes the following steps:

S1: Based on the extracorporeal circulation system of blood purification equipment that can automatically preflush provided in Embodiment 2, combine the first venous segment 22a, venous pot 22, second venous segment 22b, blood chamber lower end interface 11b, blood chamber 11, The upper end interface 11a of the blood chamber, the first arterial segment 21a, the arterial pot 21 and the second arterial segment 21b are connected in sequence to form a first pre-flush passage, and the blood chamber 11 liquid supply unit and the first waste liquid collector 51 are connected respectively. Connected to the head end and end of the first pre-flush passage. Based on the extracorporeal circulation system of blood purification equipment that can automatically preflush provided in Embodiment 2, the dialysate supply unit 42 and the second waste liquid collector 52 are respectively connected to the head end and the second preflush passage. end.

S2: Pre-flushing the first pre-flushing passage, specifically: in the first pre-flushing stage, the controller controls the peristaltic pump 23 to work so that the blood chamber 11 liquid supply unit provides the first pre-flushing passage. Flush, and allow the first pre-flush to enter the first pre-flush channel at a flow rate of 80 to 100 ml/min until the first pre-flush channel is completely filled. When the first pre-flush channel is completely filled, it enters the second pre-flush channel. In the first pre-flushing stage, at this time, the flow rate of the first pre-flushing liquid is changed to flow in the first pre-flushing channel at a flow rate of 200 to 300 ml/min. In the second pre-flushing stage, the delivery speed of the peristaltic pump 23 is increased. , which can effectively improve the flushing effect of the first pre-flushing channel and help flush away the tiny bubbles attached to the first pre-flushing channel.

In the first pre-flushing stage and the second pre-flushing stage, the first pre-flushing liquid flowing through the first pre-flushing passage is finally collected by the first waste liquid collector 51 .

In the first pre-flushing stage and the second pre-flushing stage, the air monitor 24 and the pressure monitor 32 provided on the arterial pot 21 and the venous pot 22 can simultaneously monitor the working status of the extracorporeal circulation system of the blood purification equipment. Monitor and feed back to the controller to ensure that the first pre-flush channel is in normal working condition during the first pre-flush stage and the second pre-flush stage. Specifically, during the first pre-flushing stage and the second pre-flushing stage, the air monitor 24 monitors whether there is air in the first pre-flushing passage in real time and feeds it back to the controller. When the air monitor 24 When the detection result of the air monitor 24 is abnormal, the controller controls the first prompter to send out a prompt signal to prompt the operator to confirm and adjust the liquid supply status of the blood chamber 11 liquid supply unit. In the first pre-flush stage and the second pre-flush stage, the pressures of the arterial line and the venous line are monitored through the pressure monitors 32 provided on the arterial pot 21 and the venous pot 22 respectively and fed back to The controller, when the monitoring result of the pressure monitor 32 is abnormal, controls the second prompter to send out a prompt signal to prompt the operator to confirm and adjust the connection status of the first preflush passage.

S3: Pre-flushing the second pre-flushing passage:

The controller controls the dialysate supply unit 42 to provide a second pre-flush for the second pre-flush passage. The second pre-flush enters the dialysate chamber 12 through the dialysate lower end interface 12b, and then passes through The dialysate flows out of the upper end interface 12a and is finally collected through the second waste liquid collector 52 .

At the same time, it should be noted that the order of the above steps S2 and S3 can be exchanged or performed simultaneously.

In addition, in this embodiment, since the priming mode is implemented before the treatment mode, the first priming liquid is either sterile physiological saline or dialysate, and the dialysate is obtained after 1-2 times of Sterile filtered dialysate, and due to the setting of the semipermeable membrane, the second preflush can be any one of physiological saline, sterile physiological saline, dialysate or dialysate that has been sterile filtered 1-2 times. , and the first priming liquid and the second priming liquid can be pre-prepared as finished products or obtained through online preparation, and the dialysate supply unit includes at least one pump for delivering fluid.

The above embodiments are only used to illustrate the technical solutions of the present invention and are not limiting. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently substituted. Without departing from the purpose and scope of the technical solutions of the present invention, they should all be covered by the claims of the present invention. The technology, shape, and structural parts not described in detail in the present invention are all known technologies.

Claims

A blood purification equipment extracorporeal circulation system, which is characterized by:

Dialyzer (10), the dialyzer (10) is divided into a blood chamber (11) and a dialysate chamber (12) through a semipermeable membrane, and is also provided with an upper end interface of the blood chamber that communicates with the blood chamber (11) (11a) and the blood chamber lower end interface (11b), the dialysate upper end interface (12a) and the dialysate lower end interface (12b) connected to the dialysate chamber (12), wherein the blood chamber upper end interface (11a) Higher than the lower end interface of the blood chamber (11b), and the upper end interface of the dialysate (12a) is higher than the lower end interface of the dialysate (12b);

And an extracorporeal circulation pipeline, the extracorporeal circulation pipeline includes a venous pipeline and an arterial pipeline, one end of the arterial pipeline is connected to the upper end interface (11a) of the blood chamber, and one end of the venous pipeline is connected to the Describe the lower end interface (11b) of the blood chamber.
The extracorporeal circulation system of blood purification equipment according to claim 1, characterized in that: a peristaltic pump (23) is provided on the arterial pipeline.
The extracorporeal circulation system of blood purification equipment according to claim 1, characterized in that: an air monitor (24) is provided on the venous pipeline.
An extracorporeal circulation system of blood purification equipment according to claim 1, characterized in that: an arterial pot (21) is connected in series to the arterial pipeline, and a venous pot (22) is connected in series to the venous pipeline, and the The arterial pot (21) and the venous pot (22) are respectively provided with an arterial pressure monitoring component and a venous pressure monitoring component.
An extracorporeal circulation system of blood purification equipment according to claim 1, characterized in that it also includes a blood chamber (11) liquid supply unit and a dialysate liquid supply unit (42), the blood chamber (11) liquid supply unit It is located at the end of the venous pipeline and provides the first preflush fluid for the extracorporeal circulation system. The output end of the dialysate supply unit (42) is connected to the lower end interface (12b) of the dialysate and provides the first preflush fluid for the extracorporeal circulation system. The extracorporeal circulation system provides a second priming fluid.
An extracorporeal circulation system of blood purification equipment according to claim 5, characterized in that: it also includes a waste liquid recovery unit, the waste liquid recovery unit is connected with the extracorporeal circulation pipeline and the dialyzer (10) and is used to collect The first priming fluid and the second priming fluid flow through the extracorporeal circulation system.
An extracorporeal circulation system for blood purification equipment according to claim 6, characterized in that: the waste liquid recovery unit includes a first waste liquid collector (51) and a second waste liquid collector (52), and the third waste liquid collector (52) A waste liquid collector (51) is provided at the end of the arterial pipeline and communicates with the arterial pipeline, and the second waste liquid collector (52) communicates with the dialysate upper end interface (12a).
An automatic preflushing method for extracorporeal circulation system of blood purification equipment according to any one of claims 1 to 7, characterized in that it includes the following steps:

S1: Construct a first pre-flush channel and a second pre-flush channel, and connect the blood chamber (11) liquid supply unit and dialysate liquid supply unit (42) to the first pre-flush channel and the second pre-flush channel respectively. The head end of the flushing passage connects the waste liquid recovery unit to the ends of the first pre-flushing passage and the second pre-flushing passage;

S2: Pre-flushing the first pre-flushing passage:

Control the liquid supply unit of the blood chamber (11) to provide the first pre-flush liquid to the first pre-flush channel, and make the first pre-flush liquid flow along the first pre-flush channel and finally be enriched in the first pre-flush channel. The above-mentioned waste liquid recovery unit;

S3: Pre-flushing the second pre-flushing passage:

Control the dialysate supply unit (42) to provide a second preflush fluid to the second preflush passage, and make the second preflush fluid flow along the second preflush passage and finally be enriched into waste liquid recycling unit;

Among them, the order of steps S2 and S3 can be exchanged or performed simultaneously.
An automatic pre-flushing method for extracorporeal circulation system of blood purification equipment according to claim 8, characterized in that the construction method of the first pre-flushing passage and the second pre-flushing passage is specifically:

Connect the venous pot (22) in series to the venous line and connect one end of the venous line to the lower end interface (11b) of the blood chamber. Connect the venous pot (22) in series to the arterial line and Connect one end of the arterial line to the upper end interface of the blood chamber (11a). At this time, the venous pot (22), the lower end interface of the blood chamber (11b), the blood chamber (11), and the upper end interface of the blood chamber ( 11a) and the arterial pot (21) form a first pre-flush passage, and the dialysate lower end interface (12b), dialysate chamber (12) and dialysate upper end interface (12a) form a second pre-flush passage.
An automatic preflush method for an extracorporeal circulation system of blood purification equipment according to claim 9, characterized in that the S2 specifically includes: controlling the liquid supply unit of the blood chamber (11) to be the first preflush passage. Provide a first pre-flush liquid, and allow the first pre-flush liquid to enter the first pre-flush channel at a first flow rate until the first pre-flush channel is completely filled, and then allow the first pre-flush liquid to enter the first pre-flush channel at a second flow rate. The waste liquid flows in the first pre-flush passage and is finally enriched to the waste liquid recovery unit, and the second flow rate is greater than the first flow rate.