WO2023224199A1

WO2023224199A1 - Snare-shaped electrode for electroporation

Info

Publication number: WO2023224199A1
Application number: PCT/KR2022/019380
Authority: WO
Inventors: 문진희; 박광진; 이미소
Original assignee: 주식회사 밀알
Priority date: 2022-05-19
Filing date: 2022-12-01
Publication date: 2023-11-23
Also published as: KR20230161840A

Abstract

The present invention relates to a snare-shaped electrode for electroporation, which applies electroporation to and injects a drug into a subject which is to be electroporated and injected with drug, the snare-shaped electrode comprising: an electrode receiving part (100) having a cylindrical shape and having a hole (110) formed therein; a snare electrode (200) inserted into the hole (110) and allowing the inner diameter to be expanded or reduced by forward and backward movement in a first direction (10) in the electrode receiving part (100); a plurality of electroporation and drug injection parts (300) coupled to connection holes (222) formed through the inner circumferential surface of the snare electrode (200) to come into direct contact with the subject; and an electricity supplying part (400) provided in the snare electrode (200) and connected to the electroporation and drug injection parts (300) to supply electricity to the electroporation and drug injection parts (300).

Description

Snare-shaped electroporation electrode

The present invention relates to a snare-shaped electroporation electrode, and more specifically, to an electrode capable of electroporation and drug injection into a subject for electroporation and drug injection, which is provided as a snare-shaped electrode with an inner diameter that expands or reduces the target. This relates to a snare-shaped electroporation electrode that allows electroporation and drug injection in the most appropriate form depending on the size or shape of the electrode, and as a result, can efficiently kill the target through electroporation with increased effectiveness.

A tumor refers to cells in the body that have grown autonomously and excessively. Tumors develop regardless of the overall health of the organism. Tumors are divided into malignant tumors and benign tumors, and malignant tumors are called cancer. Since benign tumors are not cancerous, there is no major problem if they are resected according to the area.

To treat a tumor, surgical methods to excise the tumor, a method to destroy the tissue by irradiating the tumor, and a method to kill cancer cells, which are malignant tumors, by administering anticancer drugs are used. For early-stage cancerous tumors, surgical methods to excise the tumor can be used. However, there is a risk for malignant tumors, and although radiation therapy or chemotherapy treatment is initially effective, it is not effective for malignant tumors.

Moreover, since the patient's immune system is low and the body becomes weak, it cannot be applied to weak patients. Therefore, a method of administering anticancer drugs to kill cancer cells, which are malignant tumors, must be used. Methods of administering anticancer drugs to malignant tumors include: Electroporation is used.

Electroporation is a technology that forms nanometer-sized pores on the surface of cell membranes by applying electric pulses with a width of nanoseconds to milliseconds to cells through electrical stimulation at a certain range of intensity. Since its discovery in the 1970s, it has been used in various biotechnologies for decades. applied to the field. Micropores on the cell membrane surface created under appropriate electric pulse conditions have the reversible property of disappearing again after a certain period of time, which is called reversible electroporation. It is mainly used to inject substances such as hydrophilic drugs, genes, enzymes, and antibodies into cells. It was used to

On the other hand, fine pores created by stronger electric pulses do not disappear and act as a mechanism that ultimately causes the cells to lose their vitality, which is called irreversible electroporation. Irreversible electroporation technology is not a desirable phenomenon in terms of reversible electroporation, but on the contrary, technological approaches that take advantage of its advantages are also being made.

For a long time, electroporation was mainly used in the food industry as a technology to kill microorganisms or as an in vitro gene injection technology for cells, but with the development of technology, it received great attention as a medical technology for treating cancer, and many studies were conducted. there is. Applications of electroporation include the delivery of DNA, RNA, siRNA, peptides, proteins, antibodies, drugs or other substances to a variety of cells such as mammalian cells, plant cells, yeast, other processing cells, bacteria, other microorganisms and cells from the human body. encompasses. Electrical stimulation during the delivery process can also be used for cell fusion in the production of other fused cells.

First, in in vitro cell fusion, cells are suspended in a buffer or medium favorable for cell survival, and the cell suspension is placed in a rectangular cuvette into which at least one flat electrode for electrical discharge is inserted. That is, when a mixed solution containing cells and foreign molecules including nucleic acids, drugs, and other compounds to be injected into the cells is placed between the electrodes and an electric pulse is applied from the outside, small pores are formed on the surface of the initial cell membrane and exist around it. Some foreign molecules move into the cell, and when the external power source is turned off, the pores on the cell membrane surface disappear and return to the initial state of the cell membrane. By taking advantage of this phenomenon, substances that cannot pass through the cell membrane can be injected into the cell.

Conventional electroporators capable of such electroporation usually include a main body that outputs electrical signals or pulse-type electrical signals; a monitoring unit that monitors electrical signals output from the main body; An alarm unit that generates an alarm signal when a failure is detected in the monitoring unit and generates a treatment completion signal when treatment is completed; a storage unit that stores patient data or treatment data; A display unit that displays a patient data input screen or treatment screen; An input unit that receives patient data or treatment setting data; and a control unit that sets the electrical signal according to the treatment setting data input from the input unit and controls the main body unit to apply the electrical signal, and the output pulse is configured to use a separate handpiece-type electrode applicator. It's common.

However, the conventional electroporator is a needle type, which involves widely injecting an apoptotic drug into the tumor area and then applying electroporation. Side effects may occur due to the anticancer drug spreading to surrounding tissues other than the tumor, and existing skin tumors When electroporation is applied to deep areas, targeting precision may decrease during the process of inserting the needle for drug injection and reinserting the electrode for electroporation.

In relation to this, according to the patent document Republic of Korea Patent Publication No. 10-2020-0109626 (published on September 23, 2020. Name of the invention: electrode for irreversible electroporation), “the electrode includes a positive electrode portion and a negative electrode portion, and the positive electrode portion and the negative electrode The technology is disclosed as "an irreversible electroporation electrode used for tumor treatment where the parts alternate and are continuously connected along one direction, the positive electrode part contains platinum, the negative electrode part contains an optical fiber, and the electrode applies near-infrared rays and pulses. .

However, in the above patent document, it is an electroporation electrode that contributes to changes in the state of the cell membrane by applying both near-infrared rays and pulses through an optical fiber, but the configuration of a fusion electrode capable of both electroporation and drug injection, and the size and shape of cancer cells. There is no disclosure at all about the characteristic configuration of the technology related to the snare-type electrode whose inner diameter can be expanded or reduced correspondingly, and the technology that improves the effectiveness of electroporation and drug injection by allowing the electrode to penetrate cancer cells, thereby solving the problems of the prior art. Couldn't solve it.

Therefore, electroporation and drug injection are possible into the target, and it is equipped with a snare-shaped electrode with an inner diameter that expands or contracts, allowing electroporation and drug injection in the most appropriate form depending on the size or shape of the target. , As a result, there is a need for a snare-type electroporation electrode that can efficiently kill a target through electroporation with increased effectiveness.

[Prior art literature]

[Patent Document]

(Patent Document 1) Republic of Korea Patent Publication No. 10-2020-0109626 (published on September 23, 2020. Title of invention: Electrode for irreversible electroporation)

The technical problem to be achieved by the present invention is to solve the problems or needs described above, and is to provide a snare-shaped electroporation electrode capable of both electroporation and drug injection into a subject.

Another object of the present invention is to provide a snare-shaped electroporation electrode that allows electroporation and drug injection in the most suitable form according to the size or shape of the target to be killed through a snare-shaped electrode whose inner diameter is expanded or reduced.

Meanwhile, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly apparent to those skilled in the art from the description below. It will be understandable.

The snare-shaped electroporation electrode according to an embodiment of the present invention for realizing the above-described problem is a snare-shaped electroporation electrode for electroporation and drug injection into a target for electroporation and drug injection, and has a cylindrical shape. It includes an electrode receiving portion 100 in which a hole 110 is formed.

Here, a snare electrode 200 is inserted into the hole 110 and moves forward and backward in the first direction inside the electrode receiving portion 100, and the inner diameter is expanded and contracted; and formed on the inner peripheral surface of the snare electrode 200. It includes a plurality of electroporation and drug injection units 300 that are coupled to the connection hole 222 and directly contact the object.

Here, an electricity supply unit 400 is provided inside the snare electrode 200 and connected to the electroporation and drug injection unit 300 to supply electricity to the electroporation and drug injection unit 300.

At this time, the snare electrode 200 is provided in a hollow shape so that the supplied drug can be delivered to the electroporation and drug injection unit 300, and moves back and forth in the first direction within the electrode receiving unit 100. Control unit 210; and a snare portion 220 formed at the distal end of the operating unit 210, the inner diameter of which expands and contracts as the operating unit 210 moves forward and backward.

Here, the snare unit 220 has a first restoring force to maintain the snare shape, so when the operating unit 210 moves forward, the inner diameter is expanded by the first restoring force, and the operating unit 210 moves backward. When moving, the end of the electrode receiving portion 100 may press one side of the snare portion 220 to reduce the inner diameter.

In addition, one side of the snare portion 220 can be gripped during assembly, thereby improving assembly efficiency, and when the manipulation portion 210 moves rearward in the first direction, the snare portion 220 accommodates the electrode. A protruding line 221 is further provided so that it can be aligned and inserted into the portion 100.

Meanwhile, the electricity supply unit 400 is connected to the electroporation and drug injection unit 300, so that when the electricity supply unit moves forward in the first direction, the electroporation and drug injection unit 300 protrudes. As a result, the electroporation and drug injection unit 300 is in close contact with the object, and when the electricity supply unit 400 moves backward in the first direction, the electroporation and drug injection unit is in close contact with the target. The unit 300 is provided to be restored, and the electricity supply unit 400 is preferably made of a hard conductive material.

In addition, the electroporation and drug injection unit 300 includes a flexible plastic material 310 that is coupled to the snare unit 220 and whose position changes by the operation of the electricity supply unit 400; and a metal material 320 that extends from the flexible plastic material 310 and is in close contact with the target to perform electroporation and drug injection.

At this time, when the electric supply unit 400 moves forward in the first direction, the flexible plastic material 310 protrudes out of the snare portion 220 so that the metal material 320 comes into close contact with the object. It is positioned so that when the electricity supply unit 400 moves rearward in the first direction, the metal material 320 is positioned inside the snare unit 220 to return to its original position.

Here, the flexible plastic material 310 has a tapered cross-section so that it can be easily moved when moving inside and outside the snare part 220 according to the operation of the electricity supply part 400. desirable.

In addition, the flexible plastic material 310 includes an electricity supply hole 311 through which electricity transmitted from the electricity supply unit 400 can be supplied; and a drug injection hole 312 for delivering the drug injected into the snare electrode 200 to the metal material 310.

Meanwhile, the metal material 320 is preferably provided with an attachment 321 having a slope at its end to facilitate electroporation and drug injection into the target.

Accordingly, according to the snare-shaped electroporation electrode according to the present invention,

First, since it has both an electric supply channel and a drug injection channel, both electroporation and drug injection are possible at the location of the target requiring treatment, thereby improving the accuracy of the electroporation method and enabling efficient electroporation treatment.

Second, electroporation is an electroporation procedure that improves the effectiveness of electroporation and drug injection by responding to the shape or size of the target through a snare-shaped electrode whose inner diameter can be reduced or expanded depending on the shape or size of the target requiring treatment. possible.

Third, after the multiple metal materials provided at the end of the snare-shaped electrode penetrate the target requiring treatment, electroporation and drug injection are performed, making it different from the conventional needle-type electrode and enabling efficient killing of target cells. .

Meanwhile, the effects that can be obtained from the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description below. You will be able to.

The following drawings attached to this specification illustrate a preferred embodiment of the present invention, and serve to further understand the technical idea of the present invention along with the detailed description of the invention. Therefore, the present invention is limited to the matters described in such drawings. It should not be interpreted in a limited way.

1 and 2 are diagrams for explaining the overall configuration of a snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Figure 3 is a diagram for explaining the detailed configuration of the snare electrode of the snare-type electroporation electrode according to a preferred embodiment of the present invention.

Figure 4 is a diagram for explaining the protruding line of the snare electrode of the snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Figure 5 is a diagram for explaining the detailed configuration of the electroporation and drug injection section of the snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Figure 6 is a diagram for explaining the electricity supply hole and drug injection hole of the electroporation and drug injection section of the snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Figure 7 is a diagram for explaining electroporation and attachment of a drug injection portion of a snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Figures 8 and 9 are diagrams for explaining the electricity supply part of the snare-shaped electroporation electrode according to a preferred embodiment of the present invention.

Specific structural or functional descriptions of the embodiments according to the concept of the present invention disclosed in this specification are merely illustrative for the purpose of explaining the embodiments according to the concept of the present invention, and the embodiments according to the concept of the present invention are It may be implemented in various forms and is not limited to the embodiments described herein.

Since the embodiments according to the concept of the present invention can make various changes and have various forms, the embodiments will be illustrated in the drawings and described in detail in this specification. However, this is not intended to limit the embodiments according to the concept of the present invention to specific disclosed forms, and includes all changes, equivalents, or substitutes included in the spirit and technical scope of the present invention.

Accordingly, the present invention is an electrode capable of electroporation and drug injection into an electroporation and drug injection target. It is provided in the form of a snare with an inner diameter that expands or contracts, allowing electroporation and drug injection in the most suitable form depending on the size or shape of the target. This is about a snare-shaped electroporation electrode that can kill a target as efficiently as possible, and will be described below with reference to the drawings.

The snare-shaped electroporation electrode for electroporation and drug injection into an electroporation and drug injection target according to an embodiment of the present invention has a cylindrical shape and a hole 110 inside, as shown in FIGS. 1 and 2. It includes an electrode receiving portion 100 that is formed.

In addition, the snare electrode 200 is inserted into the hole 110 and moves forward and backward in the first direction 10 inside the electrode receiving portion 100, and the inner diameter of the snare electrode 200 is expanded and contracted, and on the inner peripheral surface of the snare electrode 200. It includes a plurality of electroporation and drug injection units 300 that are coupled to the formed connection hole 222 and directly contact the object.

Here, it is preferable that the target is a cancer that can be immediately identified by the eye without any additional equipment, such as oral cancer, or a cancer that can be visually identified through an endoscopic camera, such as colon cancer or stomach cancer.

Cancers such as oral cancer, colon cancer, or stomach cancer have a shape or form that makes it easy to tighten a snare, so the snare electrode is the type of cancer that allows electroporation and drug injection with the highest efficiency.

Meanwhile, a snare means a noose, and is a shape that can tighten something by hanging it. In other words, by hooking a treatment target, such as cancer cells, onto the snare electrode and then tightening the snare electrode, the snare electrode can be brought into contact with the treatment target.

The meaning of the expansion and contraction of the inner diameter of the snare electrode 200 is not that the thickness of the snare electrode 200 is changed, but that the diameter is changed by moving the snare electrode 200 forward and backward while the thickness is the same. refers to the length

In other words, when the snare electrode 200 moves forward, the length of the diameter increases and the inner diameter expands. Conversely, when the snare electrode 200 moves backward, the length of the diameter decreases and the inner diameter decreases.

Here, a first manipulation unit may be provided in combination with the snare electrode 200 to manipulate the forward and backward movement of the snare electrode 200. When the first manipulation unit is moved forward and backward, the snare electrode coupled to the first manipulation unit moves forward and backward. At this time, it is preferable that the first manipulation part is provided with a first gripping groove to facilitate gripping.

At this time, forward in the first direction refers to the direction of the arrow shown in FIG. 1, and backward in the first direction refers to the direction opposite to the direction of the arrow shown in FIG. 1.

Here, it includes an electricity supply unit 400 provided inside the snare electrode 200 and connected to the electroporation and drug injection unit 300 to supply electricity to the electroporation and drug injection unit 300.

At this time, the snare electrode 200 is preferably provided in a hollow shape so that the supplied drug can be delivered to the electroporation and drug injection unit 300. In other words, the hollow formed inside is used as a passage through which the drug can move.

In addition, as shown in FIG. 3, the snare electrode 200 is formed on an operation unit 210 that moves back and forth in the first direction within the electrode receiving unit 100 and a distal end of the operation unit 210, and the operation unit ( It is preferable that 210) is provided with a snare portion 220 whose inner diameter expands and contracts as it moves forward and backward.

At this time, the first restoring force refers to the force that maintains the shape of the snare unit 220 when the manipulation unit 210 moves to the forefront. In other words, when the operation unit 210 moves to the forefront, the inner diameter of the snare part 220 is expanded to the greatest extent, and the force that maintains the shape in which the inner diameter of the snare part 220 is expanded to the greatest extent is the first force. It is resilience.

Here, as shown in FIG. 4, one side of the snare portion 220 can be gripped during assembly, thereby improving assembly efficiency, and when the manipulation portion 210 moves rearward in the first direction, the snare portion 220 It is possible to further provide a protruding line 221 so that the portion 220 can be aligned and inserted into the electrode receiving portion 100.

For example, when inserting the snare electrode 200 into the electrode receiving portion 100, the snare electrode 200 may be pushed too far into the electrode receiving portion 100, requiring reassembly. Occurs.

Here, the electrode receiving portion and the snare electrode can be easily reassembled by holding the protruding line 221 provided on the snare electrode 200 or pulling a locking member on the protruding line 221. .

At this time, the protruding line 221 is preferably positioned to protrude outside the electrode receiving unit 100 when the manipulation unit 210 is moved rearmost.

Meanwhile, the electricity supply unit 400 is connected to the electroporation and drug injection unit 300, so that when the electricity supply unit moves forward in the first direction, the electroporation and drug injection unit 300 protrudes. As a result, the electroporation and drug injection unit 300 is in close contact with the object, and when the electricity supply unit 400 moves backward in the first direction, the electroporation and drug injection unit is in close contact with the target. It is provided so that the unit 300 can be restored, and the electricity supply unit 400 is preferably made of a hard conductive material.

Here, the rigidity is such that when the electricity supply unit 400 is moved forward in the first direction, the electricity supply unit 400 is bent or rolled, preventing the electroporation and drug injection unit 300 from protruding. It is desirable to have strength to prevent failures from occurring. If the rigidity is too high, the inside of the snare electrode may be damaged or the electroporation and drug injection unit 300 may not be able to move flexibly.

Here, close contact means hanging the snare part 220 on the treatment object, tightening the treatment object as much as possible by reducing the inner diameter of the snare part 200 to fit the shape or form of the treatment object, and the snare part 220 is connected to the treatment object. While tightening the treatment target as much as possible, the electric supply unit 400 is moved forward in the first direction to protrude the drug injection unit 300, resulting in the drug injection unit 300 penetrating the treatment target. says

Here, as shown in FIG. 5, the electroporation and drug injection unit 300 includes a flexible plastic material 310 that is coupled to the snare unit 220 and whose position changes by the operation of the electricity supply unit 400; and a metal material 320 that extends from the flexible plastic material 310 and is in close contact with the target to perform electroporation and drug injection.

At this time, when the electric supply unit 400 moves forward in the first direction, the flexible plastic material 310 protrudes to the outside of the snare unit 220 or returns to the inside. It is made of a flexible material that can be easily used.

Here, when the electric supply unit 400 moves forward in the first direction, the flexible plastic material 310 protrudes out of the snare portion 220 so that the metal material 320 comes into close contact with the object. It is desirable that the metal material 320 be positioned inside the snare unit 220 so that it returns when the electricity supply unit 400 moves backward in the first direction.

Meanwhile, a second operation unit may be provided in combination with the electricity supply unit 400 to manipulate the forward and backward movement of the electricity supply unit 400. When the second operating unit is moved forward and backward, the electricity supply unit coupled to the second operating unit moves forward and backward. At this time, it is preferable that the second manipulation unit is provided with a second gripping groove to facilitate gripping.

At this time, the flexible plastic material 310 has a tapered cross-section so that it can be easily moved when moving the inside and outside of the snare part 220 according to the operation of the electricity supply part 400.

In addition, as shown in FIG. 6, the flexible plastic material 310 stores the drug injected into the electricity supply hole 311 through which electricity transmitted from the electricity supply unit 400 can be supplied and the snare electrode 200. It is preferable that each drug injection hole 312 for delivering the drug to the metal material 310 is provided.

Here, as shown in FIG. 7, the metal material 320 is provided with an attachment 321 having a slope at the end to facilitate electroporation and drug injection into the target. In other words, the attachment allows the treatment target to penetrate well, thereby maximizing the efficiency of perforation and drug injection.

Meanwhile, a step is formed in the electricity supply unit 400 to provide a step surface 411 and a step space 410, and the flexible plastic material 310 is located in the step space 410 of the electricity supply unit 400. It has a second restoring force so that when the electric supply unit 400 is manipulated to move forward in the second direction 20 through the second operation unit, the step pushes the flexible plastic material 310 and generates a pressing force. The flexible plastic material 310 may be provided to protrude out of the snare portion 220.

Here, when the electric supply unit 400 is manipulated to move backward in the second direction 20 through the second operation unit, the electric supply unit 400 returns to its original state, and the electric supply unit 400 returns to its original position, thereby causing the flexible The plastic material 310 is positioned again in the step space 410 inside the snare portion 220 by the second restoring force.

At this time, the flexible plastic material 310 protrudes out of the snare portion 220, and as a result, the metal material 320 protrudes, and the protruding metal material can be in close contact with the treatment target.

Meanwhile, the second restoring force refers to a force that allows the flexible plastic material 310 to contact the step surface 411 and to position the flexible plastic material 310 in the step space.

At this time, it is preferable that the second restoring force is provided so that its force is smaller than the pressing force. If the force of the second restoring force is greater than the pressing force, the flexible plastic material 310 may not protrude out of the snare portion 220.

On the other hand, it is possible to further provide a flow space inside the electricity supply unit 400 to allow the drug injected into the electricity supply unit 400 to flow. At this time, the electric supply unit 400 is further provided with a plurality of drug supply holes so that the drug injected into the electric supply unit 400 is delivered to the drug injection hole provided in the electroporation and drug injection unit 300. It is desirable to be

When using the snare-type electroporation electrode according to an embodiment of the present invention described above, it has both an electric supply channel and a drug injection channel, so both electroporation and drug injection are possible at the location of the target requiring treatment. It is possible to perform efficient electroporation procedures by increasing the accuracy of electroporation, and can respond to the shape or size of the target through a snare-shaped electrode whose inner diameter can be reduced or expanded depending on the shape or size of the target requiring treatment. Electroporation with improved effectiveness during electroporation and drug injection is possible, and electroporation and drug injection are possible as multiple metal materials provided at the end of the snare-shaped electrode penetrate the target requiring treatment, making it possible to perform electroporation and drug injection. It is different from other types of electrodes and enables efficient killing of target cells.

The present invention has been described above through a preferred embodiment, but the above-described embodiment is merely an illustrative explanation of the technical idea of the present invention, and various changes are possible without departing from the technical idea of the present invention. Anyone with ordinary knowledge will be able to understand. Therefore, the scope of protection of the present invention should be interpreted based on the matters stated in the patent claims, not the specific embodiments, and all technical ideas within the scope corresponding thereto should be interpreted as being included in the scope of rights of the present invention.

(Explanation of symbols)

100...electrode receptor

110...hole

200...Snare electrode

210...control panel

220...Snare section

221...connector

300... Electroporation and drug injection section

310...flexible plastic material

311...electricity supply hall

312...drug injection hole

320...metal

321...attached

400...electricity supply department

410...step space

411...step surface

Claims

In the snare-shaped electroporation electrode for electroporation and drug injection into a target,

An electrode receiving portion 100 having a cylindrical shape with a hole 110 formed therein;

A snare electrode 200 that is inserted into the hole 110 and moves forward and backward in the first direction 10 within the electrode receiving portion 100, and whose inner diameter expands and contracts;

A plurality of electroporation and drug injection units 300 coupled to the connection hole 222 formed on the inner peripheral surface of the snare electrode 200 and directly contacting the target; and

An electricity supply unit 400 provided inside the snare electrode 200 and connected to the electroporation and drug injection unit 300 to supply electricity to the electroporation and drug injection unit 300,

The snare electrode 200 is,

Characterized in that it is provided in a hollow form so that the supplied drug can be delivered to the electroporation and drug injection unit 300.

Snare-shaped electroporation electrode.
According to claim 1,

The snare electrode 200 is,

an operating unit 210 that moves back and forth in a first direction within the electrode receiving unit 100; And a snare portion 220 formed at the distal end of the operating unit 210, the inner diameter of which expands and contracts as the operating unit 210 moves forward and backward.

The snare unit 220,

It has a first restoring force to maintain the snare shape, so when the operating unit 210 moves forward, the inner diameter is expanded by the first restoring force,

When the manipulation unit 210 moves rearward, the end of the electrode receiving unit 100 presses one side of the snare unit 220 and the inner diameter is reduced.

Snare-shaped electroporation electrode.
According to claim 2,

On one side of the snare portion 220,

Assembling can be improved by enabling gripping during assembly, and when the manipulation unit 210 moves rearward in the first direction, the snare unit 220 can be aligned and inserted into the electrode receiving unit 100. Characterized in that it is further provided with a protruding line (221),

Snare-shaped electroporation electrode.
According to claim 3,

The electricity supply unit 400,

It is connected to the electroporation and drug injection unit 300, so that when the electricity supply unit moves forward in the first direction, the electroporation and drug injection unit 300 protrudes, resulting in the electroporation and drug injection. Part 300 is in close contact with the object,

When the electricity supply unit 400 moves backward in the first direction, the electroporation and drug injection unit 300 in close contact with the object is provided to be restored,

The electricity supply unit 400,

Characterized in that it is made of a hard conductive material,

Snare-shaped electroporation electrode.
According to claim 4,

The electroporation and drug injection unit 300,

A flexible plastic material 310 coupled to the snare unit 220 and whose position changes by the operation of the electricity supply unit 400; and a metal material 320 that extends from the flexible plastic material 310 and is in close contact with the object to perform electroporation and drug injection.

The flexible plastic material 310 is,

When the electricity supply unit 400 moves forward in the first direction, the metal material 320 is positioned to protrude outside the snare unit 220 in order to come into close contact with the object,

When the electricity supply unit 400 moves rearward in the first direction, the metal material 320 is provided to be positioned inside the snare unit 220 to return to its original state.

Snare-shaped electroporation electrode.
According to claim 5,

The flexible plastic material 310 is,

Characterized in that the cross-section is provided in a tapered shape so that it can be easily moved when moving the inside and outside of the snare part 220 according to the operation of the electricity supply part 400.

Snare-shaped electroporation electrode.
According to claim 6,

The flexible plastic material 310 is,

an electricity supply hole 311 through which electricity delivered from the electricity supply unit 400 can be supplied; and a drug injection hole 312 for delivering the drug injected into the snare electrode 200 to the metal material 310.

Snare-shaped electroporation electrode.
According to claim 7,

The metal material 320 is,

Characterized in that it is provided with an attachment 321 with a slope formed at the longitudinal end to enable easy electroporation and drug injection into the target.

Snare-shaped electroporation electrode.