WO2023210814A1

WO2023210814A1 - Oral composition containing inorganic porous material

Info

Publication number: WO2023210814A1
Application number: PCT/JP2023/016876
Authority: WO
Inventors: 正人宮内; 雅之古越; 広通武藤; 慶小林; 啓佑佐々木
Original assignee: 日本たばこ産業株式会社
Priority date: 2022-04-28
Filing date: 2023-04-28
Publication date: 2023-11-02

Abstract

An oral composition containing an inorganic porous material having an average grain size of 60 µm or greater as a base material, and also containing nicotine, the pore volume of pores having a pore diameter of less than 2 nm, measured through nitrogen adsorption and calculated using the HK method, in the inorganic porous material being 0.10 cm3/g or greater.

Description

Oral composition containing inorganic porous material

The present invention relates to an oral composition containing an inorganic porous material.

The oral composition that is the filler of the oral pouch product contains water. However, in products with high moisture content, moisture may seep out due to changes in humidity during storage.

Incidentally, porous silica materials are used as carriers for pharmaceuticals and the like by taking advantage of the characteristics of their pores (see Patent Documents 1 and 2). However, this patent document does not disclose the use of porous silica materials in oral compositions containing nicotine.

Special Publication No. 2015-536939 Special Publication No. 2006-518761

An object of the present invention is to provide an oral composition and an oral pouch product that suppress water seepage.

The above problem is solved by the present invention as described below.
Aspect 1
an inorganic porous material having an average particle size of 60 μm or more as a base material;
Contains nicotine and
In the inorganic porous material, the pore volume of pores with a pore diameter of less than 2 nm measured by a nitrogen adsorption method and calculated using the HK method is 0.10 cm ³ /g or more,
Oral composition.
Aspect 2
the inorganic porous material is selected from the group consisting of silica, silicate, alumina, zeolite, hydroxyapatite, hydrotalcite, and combinations thereof;
The oral composition according to aspect 1.
Aspect 3
The inorganic porous material has a BET specific surface area of 200 to 1200 m ² /g.
The oral composition according to aspect 1 or 2.
Aspect 4
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V1/(V1+V2+V3)≧5% by volume,
The oral composition according to any one of aspects 1 to 3.
Aspect 5
The oral composition according to any one of aspects 1 to 4, wherein the water content is 10% by weight or more.
Aspect 6
The oral cavity composition according to any one of aspects 1 to 5, comprising 6% by weight or more of the inorganic porous material.
Aspect 7
The oral composition according to any one of aspects 1 to 6,
A packaging material for packaging the oral composition;
An oral pouch product comprising:

The present invention can provide oral compositions and oral pouch products that suppress water seepage.

Adsorption/desorption isotherms of materials

Hereinafter, the present invention will be explained in detail. “X~Y” includes the end values of X and Y. Oral products are products that are contained in the oral cavity and the active ingredients are ingested through the oral mucosa through saliva. Oral compositions are compositions used in oral products.

1. Oral Composition The oral composition (hereinafter also simply referred to as "composition") according to this embodiment contains a specific inorganic porous material as a base material and nicotine. The base material is a material that constitutes the matrix of the composition, and is also referred to as an excipient.

(1) Inorganic porous material The inorganic porous material has pores with a pore diameter of less than 2 nm (hereinafter also referred to as "micropores"), and the pore volume of the pores is 0.10 cm ³ /g or more. The pore volume of the pores is calculated by applying the HK method to the nitrogen adsorption isotherm obtained by measurement using the nitrogen adsorption method. Specifically, the pore volume (hereinafter referred to as (also referred to as "micropore volume") can be determined. The HK method is a method used to measure micropores, and is a method for determining pore size distribution from calculations of interactions between adsorbed molecules and interactions between adsorbed molecules and pore wall atoms. Although the nitrogen adsorption method can be performed as known, it is preferable to pre-treat the inorganic porous material before the measurement. Examples of pretreatment include heating at 200 to 250°C for 2 hours for silica, and heating at 105°C for 1 hour for cellulose.

An inorganic porous material having a micropore volume within the above range has high water adsorption performance in a high humidity environment, as shown by the adsorption/desorption isotherm in FIG. Therefore, the oral composition containing the inorganic porous material is less likely to be denatured during storage, and particularly water seepage during storage is reduced. From this viewpoint, the lower limit of the micropore volume is preferably 0.10 cm ³ /g or more. The upper limit is not limited, but is preferably 1.0 cm ³ /g or less.

The BET specific surface area of the inorganic porous material is preferably 200 to 1200 m ² /g. When the BET specific surface area is within this range, the effect of efficiently adsorbing liquid components contained in the oral composition, such as fragrances and sweeteners, and maintaining the taste of the product is exhibited. From this viewpoint, the BET specific surface area is more preferably 200 to 500 m ² /g.

The micropore volume measured by the nitrogen adsorption method and the pore diameter calculated using the HK method is less than 2 nm is V1, and the pore diameter measured by the nitrogen adsorption method and calculated using the BJH method is 2 nm. When the pore volume of mesopores with a diameter of 50 nm or more is V2, and the pore volume of macropores with a pore diameter of 50 nm or more measured by mercury intrusion porosimetry is V3, it is preferable that the following relationship is satisfied.
V1/(V1+V2+V3)≧5% by volume
When the volume fraction is within this range, the moisture adsorbed in the pores becomes difficult to evaporate during storage, resulting in the effect of maintaining the moisture content of the product stably for a long period of time. If the moisture stored in the product is preserved, it is expected that the product will have a moist mouthfeel when placed in the oral cavity, giving a favorable impression to the user. From this point of view, the volume fraction is more preferably 5 to 25% by volume.

The BJH method is an analysis method based on Kelvin's capillary condensation theory, which assumes that mesopores have a cylindrical shape. The mercury intrusion method is a method in which mercury is injected into the pores of a solid surface, and the pore distribution and pore volume are determined from the relationship between the pressure applied at that time and the injected mercury volume.

The inorganic porous material is preferably selected from the group consisting of silica, silicates, alumina, zeolites, hydroxyapatites, hydrotalcites, and combinations thereof. Among these, silica is preferred from the viewpoints of easy availability and less influence on flavor.

The content of the inorganic porous material in the composition is preferably 6% by weight or more. Unless otherwise specified, the content refers to the amount in an absolutely dry state. The lower limit of the content is preferably 10% by weight or more, more preferably 15% by weight or more. The upper limit of the content is not limited, but from the viewpoint of the limit to which other raw materials can be blended, it is usually 70% by weight or less, preferably 68% by weight or less, more preferably 65% by weight or less.

The average particle size of the inorganic porous material is 60 μm or more. The average particle size of each material is the particle size (D50) at 50% cumulative volume based on the particle size distribution determined by laser diffraction particle size distribution measurement. Laser diffraction particle size distribution measurement can be performed using, for example, Mastersizer 3000 (manufactured by Malvern Panalytical). Unless otherwise specified, the average particle size means the particle size (D50) at which the volume integrated value is 50% in the particle size distribution. If the average particle size is less than the lower limit, the fluidity of the oral composition will decrease. Furthermore, if the average particle size is too high, the user will be more likely to perceive roughness due to the particles of the inorganic porous material, which may cause the product to feel unpleasant to the mouth. From this viewpoint, the lower limit of the average particle diameter is preferably 60 μm or more, more preferably 100 μm or less, and the upper limit is preferably 500 μm or less, more preferably 300 μm or less.

(2) Nicotine The composition contains nicotine. Nicotine may be contained in the form of nicotine alone or in the form of a nicotine-containing raw material. Nicotine-containing raw materials refer to raw materials containing nicotine, such as nicotine salts and stabilized nicotine. Examples of stabilized nicotine include nicotine-carrying substances such as nicotine supported on an ion exchange resin. Examples of ion exchange resins include weakly acidic cation exchange resins. As the ion exchange resin on which nicotine is supported, a resin composite specifically called nicotine placrilex containing, for example, 10% by weight or more and 20% by weight or less of nicotine can be used. The ion exchange resin used in Nicotine Puracrilex is a weakly acidic cation exchange resin. When using nicotine Puracrilex, the amount added to the oral composition is usually 0.5% by weight or more, preferably 1.0% by weight or more, and more preferably 2.0% by weight or more. preferable. On the other hand, from the viewpoint of flavor, the amount of nicotine puracrilex added to the composition is usually 15.0% by weight or less, preferably 12.0% by weight or less, and 10.0% by weight or less. is more preferable.

Furthermore, the nicotine-containing raw material may be a tobacco material containing, for example, tobacco powder obtained by crushing tobacco leaves. Tobacco powder may include shredded dried tobacco leaf lamina, fine powder, fibers, etc., and is prepared, for example, by the method described below. Tobacco leaves may include mesophylls (lamina), veins (stem), or roots. The tobacco material may contain elements derived from the midribs and roots of tobacco leaves, in addition to tobacco powder that is basically obtained from the lamina of tobacco leaves.

The particle size of the tobacco powder is not limited, but from the viewpoint of improving its familiarity in the oral cavity and enhancing the feeling of use, and the release of the flavor components contained in the tobacco powder into the oral cavity, a diameter of 1.2 mm is preferred. It is preferable to pass through a mesh, and more preferably to pass through a 1.0 mm mesh.

The tobacco species used as a raw material for tobacco powder is not particularly limited, and examples thereof include the Nicotiana genus, such as the yellow variety of Nicotiana tabacum, the Burley variety, and the Brasilia variety of Nicotiana rustica. The same species can be used for tobacco materials and tobacco leaves that will be described later.

The tobacco powder is preferably prepared as follows. First, a base is added to tobacco powder obtained by crushing tobacco leaves and mixed. The base to be added may include potassium carbonate or sodium carbonate, and is preferably added as an aqueous solution. Additionally, a pH adjuster such as sodium dihydrogen phosphate may be added, for example, to stabilize nicotine during the production of oral pouch products. The pH of the mixture after addition of the base is preferably adjusted to 8.0 to 9.0. The content of tobacco powder in this mixture is preferably 60 to 90% by weight.

After adding the base, heating is performed for example for 0.5 to 3 hours, preferably for 0.8 to 2 hours, under conditions such that the product temperature is 65 to 90°C, preferably 70 to 80°C. This sterilizes the tobacco powder. Heating can be performed by either or both of heating by steam injection and heating by a jacket. The pH of the mixture after heating is preferably 8.0 to 9.0, and the water content of the mixture after heating is preferably 10 to 50% by weight.

After heating, the obtained treated tobacco powder is dried by stopping the steam injection and heating only the jacket, if necessary. Thereafter, it may be cooled at about 15 to 25° C. for about 1 hour.

When using a tobacco material containing tobacco powder, the amount added to the oral composition is usually 0.001% by weight or more, preferably 0.01% by weight or more, and 0.05% by weight or more. It is more preferable. On the other hand, from the viewpoint of flavor, the amount added to the composition is usually 90% by weight or less, preferably 80% by weight or less, 70% by weight or less, 45% by weight or less, 40% by weight or less, or 30% by weight. It is as follows.

The nicotine-containing raw material may be a nicotine-containing extract obtained by extracting nicotine-containing substances such as tobacco leaves.

Among the above embodiments, it is preferable to use a nicotine-carrying substance from the viewpoint of accurate nicotine supply and ease of handling. Additionally, when tobacco powder is added, the color of the oral composition or oral product tends to be the color of tobacco leaves. On the other hand, when a colorless nicotine-containing compound is used, it is possible to provide white compositions and oral products. Such an embodiment is an advantage for users who prefer white oral products. The above raw materials may be used alone or in combination of two or more.

The total nicotine content in the composition is not limited, but from the viewpoint of user preference, it is usually 0.1 to 5.0% by weight. The total nicotine content in the composition is usually 0.1% by weight or more, preferably 1.0% by weight or more, and more preferably 2.0% by weight or more. On the other hand, from the viewpoint of flavor, the total nicotine content in the composition is usually 5.0% by weight or less, preferably 4.0% by weight or less, and preferably 3.0% by weight or less. More preferred. Therefore, when using a nicotine-containing raw material as a plant-derived alkaloid, the amount of the raw material is adjusted so that the total nicotine content falls within this range. When nicotine exists as an ion, the above content rate is the content rate as a nicotine ion. The nicotine content in the composition can be measured using a gas chromatography mass spectrometer (GC-MS), liquid chromatography (LC, UV detection), or the like.

(3) pH adjuster The composition includes a pH adjuster. The pH adjuster is not limited, and those that are allowed to be added to foods are preferred. Examples include sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, potassium phosphate, anhydrous sodium phosphate, sodium dihydrogen phosphate, and sodium citrate. Among these, sodium phosphate, potassium carbonate, or sodium dihydrogen phosphate is preferred from the viewpoint of influence on product taste and product stability during storage. One type of pH adjuster may be used alone, or two or more types may be used in combination in any ratio.

(4) Gelling agent, gelling aid The composition may contain a known gelling agent and the like. When the product is taken into the oral cavity, the gelling agent alleviates the foreign body sensation caused by the nonwoven fabric, especially at the initial stage of taking the product, and gives a favorable impression to the user. The gelling agent is preferably a polysaccharide having a carboxyl group as a functional group, such as carrageenan, pectin, gum arabic, xanthan, gellan gum, or gum tragacanth. Furthermore, carrageenan, pectin, and gellan gum are preferred from the viewpoint of being easily gelled in the presence of calcium ions and being able to form a crosslinked structure by creating a junction zone with carboxyl groups and cations. One type of these may be used alone, or two or more types may be used in combination in any ratio.

Examples of gelation auxiliary components include calcium ions, and the source thereof (gelation auxiliary agent) is not limited, but includes, for example, calcium halogenates (chlorides, etc.), citric acid, carbonates, sulfuric acid, etc. Examples include salts, phosphates, lactates, and the like. Among these, calcium lactate, calcium chloride, or calcium phosphate is preferable from the viewpoint of having little influence on taste, high solubility, and pH after dissolution, and calcium lactate is particularly preferable. One type of these may be used alone, or two or more types may be used in combination in any ratio.

Examples of gelling auxiliary ingredients other than calcium ions include metal ions such as magnesium, silver, zinc, copper, gold, and aluminum, which can bind the gelling agent through ionic bonds in the same way as calcium ions, and highly cationic ions. Examples include molecular ions. Sources of these (other gelling aids) include, for example, halogenates (chlorides, etc.) of these metal ions, citric acid, carbonates, sulfates, phosphates, and cationic polymers. can be mentioned. One type of these may be used alone, or two or more types may be used in combination in any ratio.

(5) Mold release agent The composition may contain a known mold release agent. However, since the inorganic porous material, especially silica, also functions as a mold release agent, it is not necessary to contain any mold release agent other than the inorganic porous material.

(6) Water The water content (water content) in the composition is 10% by weight or more from the viewpoint of ease of manufacturing the composition. Furthermore, from the viewpoint of improving production efficiency, improving caking resistance, and suppressing stickiness of the composition, the lower limit of the water content is preferably 30% by weight or more, more preferably 45% by weight or more; The upper limit is usually 60% by weight or less, preferably 50% by weight or less. Further, the water content may be 40% by weight or less, 30% by weight or less, or 20% by weight or less. The water content can be adjusted by adjusting the amount of water added or by providing heat treatment or drying treatment at the manufacturing stage. The water content of the composition is appropriately adjusted depending on the type of product (moist or dry). For example, in the case of a moist type, the water content is usually 20 to 60% by weight, preferably 30 to 50% by weight. On the other hand, in the case of a dry type, the water content is usually 5 to 20% by weight, preferably 10 to 15% by weight.

The water content (moisture content) of the composition can be measured using a heat-drying moisture meter (for example, METTER manufactured by TOLEDO: HB 43-S). For measurement, a sample is placed in a predetermined container and heated to an ultimate temperature of 100°C. The measurement ends when the amount of change becomes 1 mg or less in 60 seconds, and the moisture content is calculated from the weighed values before and after heating.

(7) Others The composition may contain other substances in addition to the above. Other substances include, for example, fragrances, sweeteners, humectants, bitterness suppressants, emulsifiers, and the like. The content of the substance is not limited, and the formulation can be adjusted as appropriate depending on the product design.

1) Flavors Flavors are not limited, and examples include menthol, leaf tobacco extract, natural plant flavors (for example, cinnamon, sage, herbs, chamomile, kudzu grass, sweet tea, cloves, lavender, cardamom, cloves, nutmeg, bergamot, and geranium). , honey essence, rose oil, lemon, orange, cinnamon bark, caraway, jasmine, ginger, coriander, vanilla extract, spearmint, peppermint, cassia, coffee, celery, cascarilla, sandalwood, cocoa, ylang ylang, fennel, anise, licorice, St. John's bread, plum extract, peach extract, etc.), sugars (e.g., glucose, fructose, isomerized sugar, caramel, honey, molasses, etc.), cocoa (powder, extract, etc.), esters (e.g., isoamyl acetate) , linalyl acetate, isoamyl propionate, linalyl butyrate, etc.), ketones (e.g., menthone, ionone, damascenone, ethylmaltol, etc.), alcohols (e.g., geraniol, linalool, anethole, eugenol, etc.), aldehydes (e.g., vanillin) , benzaldehyde, anisaldehyde, etc.), lactones (e.g., γ-undecalactone, γ-nonalactone, etc.), animal fragrances (e.g., musk, ambergris, civet, castoreum, etc.), and hydrocarbons (e.g., limonene, etc.). , pinene, etc.). One type of fragrance may be used alone, or two or more types may be used in combination in any ratio.

2) Sweeteners Examples of sweeteners include, but are not limited to, sugar alcohols such as xylitol, maltitol, and erythritol; and acesulfame potassium, sucralose, and aspartame. Sugar alcohols are preferred from the viewpoint of taste adjustment. One type of sweetener may be used alone, or two or more types may be used in combination in any ratio.

The type of sugar alcohol is not particularly limited, and examples include xylitol, maltitol, erythritol, sorbitol, mannitol, and lactitol. Among these, maltitol is preferred from the viewpoint of imparting good flavor. One type of these substances may be used alone, or two or more types may be used in combination in any ratio.

The content of sugar alcohols in the composition (if it contains two or more types of sugar alcohols, their total content) is not limited, but from the perspective of flavor adjustment, it is usually 1% by weight or more, and the amount of % or more, more preferably 10% by weight or more. Further, the upper limit thereof is usually 80% by weight or less, preferably 70% by weight or less, and more preferably 60% by weight or less.

3) Bitter taste suppressor The bitter taste suppressor is not limited, but includes, for example, soybean lecithin. Soybean lecithin is a phospholipid, and specific examples include phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid. As a bitter taste suppressant, one type may be used alone, or two or more types may be used in combination in any ratio.

4) Moisturizer Moisturizers are not limited, but include, for example, polyhydric alcohols such as glycerin and propylene glycol. From the viewpoint of product preservability, glycerin is preferred. As a humectant, one type may be used alone, or two or more types may be used in combination in any ratio.

5) Emulsifier, surfactant Emulsifiers are not limited, but examples include emulsifiers added to foods. Examples of the emulsifier include one or more selected from the group consisting of sucrose fatty acid ester, organic acid glycerin fatty acid ester, polyglycerin fatty acid ester, and lecithin. Examples of sucrose fatty acid esters include sucrose palmitate and sucrose stearate. Examples of the organic acid glycerin fatty acid ester include succinic acid glycerin fatty acid ester and diacetyl tartrate glycerin fatty acid ester. As the polyglycerin fatty acid ester, decaglycerin fatty acid ester can be mentioned. The content of the emulsifier in the composition is preferably such that the total content of the emulsifier and the aforementioned polyglycerol fatty acid ester falls within the range described above as the content of the polyglycerol fatty acid ester.

The degree of polymerization of glycerin in the polyglycerin fatty acid ester is preferably 2 to 10. Polyglycerol fatty acid ester functions as an emulsifier. Therefore, by containing the polyglycerol fatty acid ester, the components of the composition can be kept in a uniformly mixed state, and the flavor components can be kept stable, so that the flavor of the composition can be improved. In addition, the polyglycerin fatty acid ester can impart appropriate viscosity to the composition and bind each component together, so it can suppress the dryness of the composition and improve the feeling of use, flavor, etc. can. In addition, even if the composition is a dry type with a low water content (moisture content), it is possible to prevent the composition from scattering when filling an exterior material such as a pouch with the composition. In this way, by including the polyglycerol fatty acid ester in the composition, production efficiency such as work efficiency and yield in producing oral products can be improved.

Polyglycerin fatty acid ester is a fatty acid ester of a dehydrated condensate of glycerin, and the degree of polymerization of glycerin is usually 2 or more, and may be 3 or more, and is usually 10 or less, and 8 or less. good.

The fatty acid ester group (RCOO- group) of polyglycerin fatty acid ester is derived from a fatty acid. The fatty acid is not limited and may be a saturated fatty acid or an unsaturated fatty acid. In addition, from the viewpoint of good flavor and production efficiency, the number of carbon atoms in the fatty acid is usually 10 or more, preferably 12 or more, more preferably 14 or more, and even more preferably 16 or more. Moreover, it is usually 30 or less, preferably 26 or less, more preferably 22 or less, and even more preferably 20 or less. The fatty acid may have a substituent or may be unsubstituted.

In addition, the number of fatty acid ester groups that one molecule of polyglycerol fatty acid ester has is not limited as long as the polyglycerol fatty acid ester has a structure that can function as an emulsifier, and depends on the degree of polymerization of glycerin and the number of hydroxyl groups derived from glycerin. It can be selected as appropriate. A structure that can function as an emulsifier is a structure that has both a fatty acid moiety that serves as a lipophilic group and a polyhydric alcohol moiety that serves as a hydrophilic group. Specifically, the number of fatty acid ester groups per molecule of polyglycerin fatty acid ester should normally be one or more. Further, the number of hydroxyl groups derived from glycerin may be one or more.

The degree of polymerization of glycerin and the type and number of fatty acid ester groups in the polyglycerin fatty acid ester can be arbitrarily combined as described above. More specifically, the alcohol component of the polyglycerin fatty acid ester may be diglycerin, triglycerin, tetraglycerin, pentaglycerin, hexaglycerin, heptaglycerin, octaglycerin, nonaglycerin, or decaglycerin. The acid component of the polyglycerol fatty acid ester may be a fatty acid such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, α-linolenic acid, and the like. Further, the polyglycerin fatty acid ester may be a monoester, diester, triester, tetraester, pentaester, or the like. As the polyglycerol fatty acid ester, one type may be used alone, or two or more types may be used in combination in any ratio.

From the viewpoint of good flavor and workability during production, the polyglycerin fatty acid ester is preferably one or more selected from diglycerin monofatty acid ester and decaglycerin fatty acid ester. The diglycerin monofatty acid ester is preferably selected from the group consisting of diglycerin monolaurate, diglycerin monomyristate, diglycerin monopalmitate, diglycerin monostearate and diglycerin monooleate; More preferred is oleate. The decaglycerin fatty acid ester is preferably selected from the group consisting of decaglycerin laurate, decaglycerin myristate, decaglycerin palmitate, decaglycerin stearate and decaglycerin oleate; More preferably it is selected from the group consisting of myristate, decaglycerin monopalmitate, decaglycerin monostearate and decaglycerin monooleate.

The content of polyglycerol fatty acid esters in the composition (if it contains two or more types of polyglycerol fatty acid esters, their total content) is not limited, but from the viewpoint of obtaining good flavor and improving production efficiency. , usually at least 0.1% by weight, preferably at least 0.2% by weight, more preferably at least 0.3% by weight, even more preferably at least 0.5% by weight. Further, the content of the polyglycerol fatty acid ester is usually 20.0% by weight or less, preferably 15.0% by weight or less, and 10.0% by weight or less, preferably 15.0% by weight or less, from the viewpoint of imparting appropriate viscosity to the composition. It is more preferably at most 8.0% by weight, even more preferably at most 8.0% by weight.

The HLB value of the polyglycerol fatty acid ester is not limited, but from the viewpoint of obtaining good flavor and improving production efficiency, it is usually 6.0 or more, preferably 7.0 or more, and usually 20.0 or less, preferably It is 18.0 or less, more preferably 16.0 or less.

6) Taste component The taste component may further include a compound exhibiting salty, bitter, sour, umami, or the like. Non-limiting examples of suitable flavoring ingredients include sodium chloride, potassium chloride, ammonium chloride, peptides, citric acid, ascorbic acid, sodium glutamate, arginine, gingerol, gymnema, and the like. The taste component to be blended is preferably a ligand for a taste receptor. When these taste components are received by taste receptors in the oral cavity, they can impart a flavor effect to the product's taste due to fragrances, etc., and contribute to improving the taste and palatability of the product. Typical amounts of these taste components in the composition are usually 0.5% by weight or more and 10% by weight or less, more preferably 2% by weight or more and 8% by weight or less, and even more preferably , 3% by weight or more and 5% by weight or less.

(8) Characteristics of composition 1) pH
The pH of the composition is not limited, but from the viewpoint of influence on taste, it is usually 7.0 or higher, preferably 7.5 or higher, more preferably 8.0 or higher, and usually 10 or higher. .0 or less, preferably 9.5 or less, and more preferably 9.0 or less. The pH is a measured value at 25°C.

The pH of the composition at a measurement temperature of 25°C is determined using a pH analyzer (for example, LAQUA F-72 flat ISFET pH electrode manufactured by Horiba), and 20 mL of water is added to 2 g of the composition, shaken for 10 minutes, It can be measured by measuring the supernatant liquid. For example, calibrate the equipment using phthalate pH standard solution (pH 4.01), neutral phosphate pH standard solution (pH 6.86), borate pH standard solution (pH 9.18) (all manufactured by Wako Pure Chemical Industries). It is preferable to perform three-point calibration using

2) Moisture adsorption/desorption isotherm The ease with which water oozes out during storage can be evaluated by measuring the moisture adsorption/desorption isotherm of the composition. Specifically, a composition that has high water adsorption performance in a high-humidity environment is less likely to seep out water during storage and has excellent storage stability. Since the base material has a large contribution to this property, it can be evaluated by measuring the moisture adsorption/desorption isotherm of the base material. The moisture adsorption/desorption isotherm is measured as follows.

As a device for measuring the isothermal behavior of adsorption and desorption of moisture, a known device can be used, and for example, BELSORP MAX II from Microtrac BEL (Microtrac Bell Co., Ltd.) can be used. As a pretreatment, the sample is preferably vacuum-dried at 105° C. until the leakage is 1 Pa/min or less. Next, the adsorption isothermal behavior is measured at relative pressure intervals of 0.025 from 0.025 to 0.3 and at intervals of 0.05 relative pressure from 0.3 to 0.95. After the relative pressure reaches 0.95, the desorption isothermal behavior is measured at the same relative pressure intervals as above until the relative pressure reaches 0.1, and an adsorption/desorption isotherm is created. The equilibration conditions are that when the relative pressure is 0.9 or less, the pressure change is 0.3% or less in 300 seconds, and when the relative pressure is 0.9 or more, the pressure change is 0.3 Pa or less in 300 seconds.

(9) Method for producing composition The composition can be produced by any method, but it is preferably produced through a step of mixing the base material, nicotine, and, if necessary, the above-mentioned components. Mixing can be performed by charging all raw materials into a mixer and mixing them.

In a preferred manufacturing method, first, the base material, nicotine, and optionally water and other substances (sweeteners, flavors, humectants, etc.) are mixed to obtain a first mixture. At this time, heating may be applied. Furthermore, the order of mixing each raw material is not limited, and they may be mixed in any order or at the same time by being added to the mixer, or solid raw materials may be mixed uniformly, then liquid raw materials may be added and further mixed. good. From the viewpoint of workability, the latter embodiment is preferable.

To the mixture obtained as above, an aqueous solution containing a pH adjuster, a sweetener such as acesulfame potassium, a flavoring agent such as menthol, a bitterness suppressant such as soybean lecithin, and a humectant such as glycerin are added as necessary (additives addition step). The above additives may be added in solid form or as an aqueous solution dissolved in water. When added in an aqueous solution, it may be added in advance by dissolving it in a predetermined amount of water to achieve the final moisture content of the oral product.

2. Oral Pouch Products Oral products are used by being placed in the mouth. Oral pouch products are compositions that contain a composition (also called the main material or filler) within a sealed water-insoluble packaging material (also called a pouch), and saliva penetrates through the pouch and is contained within the pouch. A product that dissolves the ingredients in the product and can then be passed through a pouch and transported into the oral cavity.

(1) Pouch Pouches are not limited to known pouches as long as they can package the filling, do not dissolve in water, and can permeate liquids (water, saliva, etc.) and water-soluble components in the filling. Can be used. Examples of the material for the pouch include cellulose nonwoven fabric, and commercially available nonwoven fabrics may also be used. A pouch product can be produced by forming a sheet made of such a material into a bag shape, filling the bag with a filler, and sealing the bag by means such as heat sealing.

The basis weight of the sheet is not particularly limited, and is usually 12 gsm (g/m ² ) or more and 54 gsm or less, preferably 24 gsm or more and 30 gsm or less. The thickness of the sheet is not particularly limited, and is usually 100 μm or more and 300 μm or less, preferably 175 μm or more and 215 μm or less.

At least one of the inner and outer surfaces of the pouch may be partially coated with a water-repellent material. A water-repellent fluororesin is suitable as the water-repellent material. Specifically, this type of water-repellent fluororesin includes Asahi Guard (registered trademark) manufactured by Asahi Glass Co., Ltd. Water-repellent fluororesins are applied to packaging materials for foods and products containing fats and oils, such as confectionery, dairy products, prepared foods, fast food, and pet food. Therefore, this type of water-repellent fluororesin is safe even when applied to pouches placed in the oral cavity. The water-repellent material is not limited to fluororesin, and may be a water-repellent material such as paraffin resin, silicone resin, or epoxy resin.

The pouch may contain any ingredients. Examples of such components include raw materials that adjust aroma and taste, fragrances, additives, tobacco extracts, and pigments. Furthermore, the manner in which these components are contained is not limited, and examples include methods in which they are applied to the surface of the pouch, impregnated, and in the case of fibers, they are contained in the fibers.

The appearance of the pouch is also not limited. Pouches may be non-transparent, translucent, or transparent. If the pouch is translucent or transparent, the filling can be seen through.

The size of the oral pouch product is not limited. The size of the product before use may be such that the lower limit of the long side is 25 mm or more, 28 mm or more, 35 mm or more, or 38 mm or more. Moreover, the upper limit may be 40 mm or less. The lower limit of the short side may be 10 mm or more or 14 mm or more. Moreover, the upper limit may be 20 mm or less or 18 mm or less. The ratio of the weight of the filler to the total weight of the oral pouch product is not limited, but is usually 80% by weight or more, preferably 85% by weight or more, more preferably 90% by weight or more, and , usually 99% by weight or less, preferably 97% by weight or less, more preferably 95% by weight or less.

(2) Filler The oral pouch product is filled with the composition as a filler. The amount of filler per oral pouch product is preferably between 0.4 and 1.5 g.

(3) Method for manufacturing oral pouch products Oral pouch products can be manufactured by packaging the composition with an exterior material (packaging process). The packaging method is not limited, and any known method can be applied. For example, a known method can be used, such as a method in which the composition is poured into a bag-shaped nonwoven fabric and then sealed. In the packaging process, desired additional water may be added after sealing (water addition process). For example, if the final composition has a water content of 50% by weight and the filled composition has a water content of 15% by weight, the remaining 35% by weight of water is added.

Embodiments are described below.
Aspect 1
an inorganic porous material having an average particle size of 60 μm or more as a base material;
Contains nicotine and
In the inorganic porous material, the pore volume of pores with a pore diameter of less than 2 nm measured by a nitrogen adsorption method and calculated using the HK method is 0.10 cm ³ /g or more,
Oral composition.
Aspect 2
the inorganic porous material is selected from the group consisting of silica, silicate, alumina, zeolite, hydroxyapatite, hydrotalcite, and combinations thereof;
The oral composition according to aspect 1.
Aspect 3
The inorganic porous material has a BET specific surface area of 200 to 1200 m ² /g.
The oral composition according to aspect 1 or 2.
Aspect 4
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V1/(V1+V2+V3)≧5% by volume,
The oral composition according to any one of aspects 1 to 3.
Aspect 5
The oral composition according to any one of aspects 1 to 4, having a water content of 10% by weight or more.
Aspect 6
The oral cavity composition according to any one of aspects 1 to 5, comprising 6% by weight or more of the inorganic porous material.
Aspect 7
The oral composition according to any one of aspects 1 to 6,
A packaging material for packaging the oral composition;
An oral pouch product comprising:

[Example 1] Production of oral composition As a base material, 100.0 g of silica (manufactured by Evonic, SIPERNAT2200), 3.87 g of nicotine, 45.1 g of anhydrous sodium phosphate aqueous solution, 4.79 g of anhydrous citric acid aqueous solution, 14.03 g of a sodium chloride aqueous solution and 23.4 g of an acesulfame K aqueous solution were added and mixed until homogeneous to obtain a mixture A. The obtained mixture A was subjected to jacket heating (can wall temperature: 100° C.). Thereafter, the mixture was cooled for 30 minutes at an ambient temperature of 20° C. to obtain a mixture B (11% water content after cooling). To the cooled mixture B, 67.7 g of tripotassium phosphate aqueous solution, 28.5 g of trisodium phosphate aqueous solution, 20 g of gellan gum aqueous solution, and other components were added to form an oral composition (water content 41.2% by weight, 263 g of pH 8.51) were obtained.

[Example 2]
An oral composition was produced in the same manner as in Example 1, except that 36.0 g of powdered cellulose (VITACEL L00, manufactured by Rettenmeyer) and 66.0 g of the silica were mixed and used as a base material.

[Example 3]
An oral composition was produced in the same manner as in Example 1, except that 40.0 g of powdered cellulose (VITACEL L00, manufactured by Rettenmeyer) and 60.0 g of the silica were mixed and used as a base material.

[Example 4]
An oral composition was produced in the same manner as in Example 1, except that 30.0 g of powdered cellulose (VITACEL L00, manufactured by Rettenmeyer) and 70.0 g of the silica were mixed and used as a base material.

[Comparative example 1]
An oral composition was produced in the same manner as in Example 1, except that 100.0 g of microcrystalline cellulose (VIVAPUR200, manufactured by Rettenmeyer) was used as the base material. Table 1 shows the composition, and Table 2 shows the physical properties of the base material.

Figure 1 shows the moisture adsorption/desorption isotherms of each material. The silica used in the examples has a higher ability to adsorb water, especially in high-humidity environments, than cellulose-based base materials, and it can be said that the product is less likely to be denatured by the storage environment, that is, water seepage is reduced. .

Various measurements were carried out as follows.
<Average particle size>
The average particle size of each material means the particle size (D50) at 50% cumulative volume based on the particle size distribution determined by laser diffraction particle size distribution measurement. Laser diffraction particle size distribution was measured using Mastersizer 3000 (manufactured by Malvern Panalytical).

<Water content>
It was measured using a heat drying moisture meter (METTER TOLEDO: HB 43-S). At the time of measurement, the sample was placed in a predetermined container and heated to an ultimate temperature of 100°C. The measurement was terminated when the amount of change became 1 mg or less in 60 seconds, and the water content was calculated from the weighed values before and after heating.

<Micropore analysis using nitrogen adsorption method>
Pretreatment was performed under the following conditions.
Silica: Heated at 250°C for 2 hours Cellulose: Heated at 105°C for 1 hour Next, a nitrogen adsorption isotherm was obtained and the micropore volume was determined by the HK method.
The measurement was performed using a gas adsorption amount measuring device AutoSorb-1 (manufactured by Quantachrome).

<pH>
Using a pH analyzer (manufactured by Horiba, Ltd.: LAQUA F-72 flat ISFET pH electrode), 20 ml of water was added to 2 g of the composition, shaken for 10 minutes, and the supernatant liquid was measured. For example, calibrate the equipment using phthalate pH standard solution (pH 4.01), neutral phosphate pH standard solution (pH 6.86), borate pH standard solution (pH 9.18) (all manufactured by Wako Pure Chemical Industries). This was done using a three-point calibration.

<Moisture adsorption/desorption isotherm>
Measuring device: BELSORP MAX II from MicrotracBEL (Microtrac Bell Co., Ltd.) was used. As a pretreatment, the sample was vacuum dried at 105° C. until the leakage was 1 Pa/min or less. The measurement conditions are: from relative pressure (humidity) from 0.025 to 0.3, adsorption isotherms are measured at relative pressure intervals of 0.025; from 0.3 to 0.95, adsorption isotherms are measured at relative pressure intervals of 0.05; Once a relative pressure of 0.95 was reached, the desorption isotherm was measured at the same relative pressure interval up to a relative pressure of 0.1. (For TSP, the measurement time is long and the measurement accuracy is reduced, so the relative pressure translation was limited to 0.5.) The equilibration conditions were that when the relative pressure was 0.9 or less, the pressure change was 0.3% or less in 300 seconds, and when the relative pressure was If the pressure is 0.9 or more, the pressure value will fluctuate to 0.3 Pa or less in 300 seconds.

Claims

an inorganic porous material having an average particle size of 60 μm or more as a base material;
Contains nicotine and
In the inorganic porous material, the pore volume of pores with a pore diameter of less than 2 nm measured by a nitrogen adsorption method and calculated using the HK method is 0.10 cm 3 /g or more,
Oral composition.
the inorganic porous material is selected from the group consisting of silica, silicate, alumina, zeolite, hydroxyapatite, hydrotalcite, and combinations thereof;
The oral composition according to claim 1.
The inorganic porous material has a BET specific surface area of 200 to 1200 m 2 /g.
The oral composition according to claim 1 or 2.
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V1/(V1+V2+V3)≧5% by volume,
The oral composition according to any one of claims 1 to 3.
The oral composition according to any one of claims 1 to 4, wherein the water content is 10% by weight or more.
The oral cavity composition according to any one of claims 1 to 5, comprising 6% by weight or more of the inorganic porous material.
The oral composition according to any one of claims 1 to 6,
A packaging material for packaging the oral composition;
An oral pouch product comprising: