WO2023210812A1

WO2023210812A1 - Oral-cavity composition containing porous material

Info

Publication number: WO2023210812A1
Application number: PCT/JP2023/016868
Authority: WO
Inventors: 正人宮内; 雅之古越; 広通武藤; 慶小林; 啓佑佐々木
Original assignee: 日本たばこ産業株式会社
Priority date: 2022-04-28
Filing date: 2023-04-28
Publication date: 2023-11-02

Abstract

This oral-cavity composition comprises: a porous material having an average particle diameter of 60 µm or greater as a base material; and nicotine. The volume of pores of the porous material, the pores having diameters of at least 50 nm, is 1.90-2.35 cm3/g when measured by mercury porosimetry.

Description

Oral composition containing porous material

The present invention relates to oral compositions containing porous materials.

The oral composition that is the filler of the oral pouch product contains water. Therefore, there is a possibility that the composition may become lumps during storage, resulting in a decrease in handling properties.

Incidentally, porous silica materials are used as carriers for pharmaceuticals and the like by taking advantage of the characteristics of their pores (see Patent Documents 1 and 2). Patent Document 3 discloses an oral product in which nicotine is absorbed into porous cellulose fibers.

Special Publication No. 2015-536939 Special Publication No. 2006-518761 JP 2019-150032 Publication

The above-mentioned patent document does not include any description regarding the handling properties of the oral composition. In view of such circumstances, an object of the present invention is to provide an oral composition and an oral pouch product that have excellent storage stability.

The above-mentioned problems are solved by the present invention described below.
Aspect 1
A porous material having an average particle size of 60 μm or more as a base material,
Contains nicotine and
In the porous material, the pore volume of pores having a pore diameter of 50 nm or more as measured by mercury intrusion porosimetry is 1.90 to 2.35 cm ³ /g.
Oral composition.
Aspect 2
the porous material is selected from the group consisting of silica, silicates, regenerated cellulose, and combinations thereof;
Oral composition according to aspect 1.
Aspect 3
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V3/(V1+V2+V3)≧50% by volume,
The oral composition according to aspect 1 or 2.
Aspect 4
The oral composition according to any one of aspects 1 to 4, having a water content of 15% by weight or more.
Aspect 5
The oral composition according to any one of aspects 1 to 5, comprising 6% by weight or more of the porous material.
Aspect 6
the porous material is an inorganic porous material selected from the group consisting of silica, silicates, and combinations thereof;
The average particle size of the inorganic porous material is 60 μm or more,
The oral composition according to any one of aspects 1 to 5.
Aspect 7
The inorganic porous material has a BET specific surface area of 200 to 1200 m ² /g.
The oral composition according to any one of aspects 1 to 6.
Aspect 8
The oral composition according to any one of aspects 1 to 7,
A packaging material for packaging the oral composition;
An oral pouch product comprising:

The present invention can provide oral compositions and oral pouch products with excellent storage stability.

Hereinafter, the present invention will be explained in detail. In the present invention, "X~Y" includes its end values, ie, X and Y. Oral products are products that are contained in the oral cavity and the active ingredients are ingested through the oral mucosa through saliva. Oral compositions are compositions used in oral products.

1. Oral Composition The oral composition (hereinafter also simply referred to as "composition") according to this embodiment includes a specific porous material as a base material and nicotine. The base material is a material that constitutes the matrix of the composition, and is also referred to as an excipient.

(1) Porous material A porous material has pores with a pore diameter of 50 nm or more (hereinafter also referred to as "macropores"), and the pore volume of the pores is 1.90 to 2.35 cm. ³ /g. The pore volume of the pores is measured by mercury porosimetry. The mercury intrusion method is a method in which mercury is injected into the pores of a solid surface, and the pore distribution and pore volume are determined from the relationship between the pressure applied at that time and the injected mercury volume.

A porous material having a macropore volume within the above range has excellent fluidity. Although the reason for this is not limited, it is thought that water is adsorbed to the macropores, thereby preventing the porous materials from coagulating with each other or with other materials. Therefore, in an oral composition containing an inorganic porous material, uneven distribution of the composition does not occur during storage, and lumps are less likely to form. Therefore, oral compositions containing porous materials have excellent storage stability. From this viewpoint, the lower limit of the macropore volume is preferably 1.00 cm ³ /g or more. The upper limit is not limited, but is preferably 3.00 cm ³ /g or less.

The micropore volume measured by the nitrogen adsorption method and the pore diameter calculated using the HK method is less than 2 nm is V1, and the pore diameter measured by the nitrogen adsorption method and calculated using the BJH method is 2 nm. When the pore volume of mesopores with a diameter of 50 nm or more is V2, and the pore volume of macropores with a pore diameter of 50 nm or more measured by mercury intrusion porosimetry is V3, it is preferable that the following relationship is satisfied.
V3/(V1+V2+V3)≧50% by volume
When the volume fraction is within this range, the effect of improving fluidity becomes more pronounced. From this point of view, the volume fraction is more preferably 55 to 99% by volume.

V2 is calculated by applying the BJH method to the nitrogen adsorption isotherm obtained by measurement using the nitrogen adsorption method. Specifically, by determining the nitrogen gas adsorption isotherm of the inorganic porous material, applying the BJH method to this, and accumulating the pore volume in a range of predetermined pore diameters, pore volume) can be determined. Although the nitrogen adsorption method can be performed as known, it is preferable to pre-treat the inorganic porous material before the measurement. Examples of pretreatment include heating at 200 to 250°C for 2 hours for silica, and heating at 105°C for 1 hour for cellulose. The BJH method is an analysis method based on Kelvin's capillary condensation theory, which assumes that mesopores have a cylindrical shape. V1 is calculated by applying the BJH method to the nitrogen adsorption isotherm. The HK method is a method used to measure micropores, and is a method for determining pore size distribution from calculations of interactions between adsorbed molecules and interactions between adsorbed molecules and pore wall atoms.

The content of the porous material in the composition is preferably 6% by weight or more. Unless otherwise specified, the content refers to the amount in an absolutely dry state. The lower limit of the content is preferably 10% by weight or more, more preferably 15% by weight or more. The upper limit of the content is not limited, but from the viewpoint of the limit to which other raw materials can be blended, it is usually 70% by weight or less, preferably 68% by weight or less, more preferably 65% by weight or less.

The average particle size of the porous material is 60 μm or more. The average particle size of each material is the particle size (D50) at 50% cumulative volume based on the particle size distribution determined by laser diffraction particle size distribution measurement. Laser diffraction particle size distribution measurement can be performed using, for example, Mastersizer 3000 (manufactured by Malvern Panalytical). Unless otherwise specified, the average particle size means the particle size (D50) at which the volume integrated value is 50% in the particle size distribution. If the average particle size is less than the lower limit, the fluidity of the oral composition will decrease. Furthermore, if the average particle size is too high, the particles will swell upon contact with water, forming lumps and causing uneven distribution of the composition. From this viewpoint, the lower limit of the average particle diameter is preferably 60 μm or more, more preferably 100 μm or more, and the upper limit is preferably 500 μm or less, more preferably 300 μm or less.

The porous material is preferably selected from the group consisting of silica, silicates, regenerated cellulose, and combinations thereof. From the viewpoint of availability, the porous material is preferably an inorganic porous material selected from the group consisting of silica, silicates, and combinations thereof. The inorganic porous material will be explained below.

The BET specific surface area of the inorganic porous material is preferably 200 to 1200 m ² /g. When the BET specific surface area is within this range, the effect of efficiently adsorbing liquid components contained in the oral composition, such as fragrances and sweeteners, and maintaining the taste of the product is exhibited. From this viewpoint, the BET specific surface area is more preferably 200 to 500 m ² /g.

The average particle size of the inorganic porous material is preferably 60 μm or more. Average particle size is measured as described above. If the average particle size is less than the lower limit, the fluidity of the oral composition will decrease. Furthermore, if the average particle size is too high, the user will be more likely to perceive roughness due to the particles of the inorganic porous material, which may cause the product to feel unpleasant to the mouth. From this viewpoint, the lower limit of the average particle diameter is preferably 60 μm or more, and the upper limit is preferably 500 μm or less.

The inorganic porous material is preferably silica from the viewpoint of ease of availability and less influence on flavor.

(2) Nicotine The composition contains nicotine. Nicotine may be contained in the form of nicotine alone or in the form of a nicotine-containing raw material. Nicotine-containing raw materials refer to raw materials containing nicotine, such as nicotine salts and stabilized nicotine. Examples of stabilized nicotine include nicotine-carrying substances such as nicotine supported on an ion exchange resin. Examples of ion exchange resins include weakly acidic cation exchange resins. As the ion exchange resin on which nicotine is supported, a resin composite specifically called nicotine placrilex containing, for example, 10% by weight or more and 20% by weight or less of nicotine can be used. The ion exchange resin used in Nicotine Puracrilex is a weakly acidic cation exchange resin. When using nicotine Puracrilex, the amount added to the oral composition is usually 0.5% by weight or more, preferably 1.0% by weight or more, and more preferably 2.0% by weight or more. preferable. On the other hand, from the viewpoint of flavor, the amount of nicotine puracrilex added to the composition is usually 15.0% by weight or less, preferably 12.0% by weight or less, and 10.0% by weight or less. is more preferable.

Furthermore, the nicotine-containing raw material may be a tobacco material containing, for example, tobacco powder obtained by crushing tobacco leaves. Tobacco powder may include shredded dried tobacco leaf lamina, fine powder, fibers, etc., and is prepared, for example, by the method described below. Tobacco leaves may include mesophylls (lamina), veins (stem), or roots. The tobacco material may contain elements derived from the midribs and roots of tobacco leaves, in addition to tobacco powder that is basically obtained from the lamina of tobacco leaves.

The particle size of the tobacco powder is not limited, but from the viewpoint of improving its familiarity in the oral cavity and enhancing the feeling of use, and the release of the flavor components contained in the tobacco powder into the oral cavity, a diameter of 1.2 mm is preferred. It is preferable to pass through a mesh, and more preferably to pass through a 1.0 mm mesh.

The tobacco species used as a raw material for tobacco powder is not particularly limited, and examples thereof include the Nicotiana genus, such as the yellow variety of Nicotiana tabacum, the Burley variety, and the Brasilia variety of Nicotiana rustica. The same species can be used for tobacco materials and tobacco leaves that will be described later.

The tobacco powder is preferably prepared as follows. First, a base is added to tobacco powder obtained by crushing tobacco leaves and mixed. The base to be added may include potassium carbonate or sodium carbonate, and is preferably added as an aqueous solution. Additionally, a pH adjuster such as sodium dihydrogen phosphate may be added, for example, to stabilize nicotine during the production of oral pouch products. The pH of the mixture after addition of the base is preferably adjusted to 8.0 to 9.0. The content of tobacco powder in this mixture is preferably 60 to 90% by weight.

After adding the base, heating is performed for example for 0.5 to 3 hours, preferably for 0.8 to 2 hours, under conditions such that the product temperature is 65 to 90°C, preferably 70 to 80°C. This sterilizes the tobacco powder. Heating can be performed by either or both of heating by steam injection and heating by a jacket. The pH of the mixture after heating is preferably 8.0 to 9.0, and the water content of the mixture after heating is preferably 10 to 50% by weight.

After heating, the obtained treated tobacco powder is dried by stopping the steam injection and heating only the jacket, if necessary. Thereafter, it may be cooled at about 15 to 25° C. for about 1 hour.

When using a tobacco material containing tobacco powder, the amount added to the oral composition is usually 0.001% by weight or more, preferably 0.01% by weight or more, and 0.05% by weight or more. It is more preferable. On the other hand, from the viewpoint of flavor, the amount added to the composition is usually 90% by weight or less, preferably 80% by weight or less, 70% by weight or less, 45% by weight or less, 40% by weight or less, or 30% by weight. It is as follows.

The nicotine-containing raw material may be a nicotine-containing extract obtained by extracting nicotine-containing substances such as tobacco leaves.

Among the above embodiments, it is preferable to use a nicotine-carrying substance from the viewpoint of accurate nicotine supply and ease of handling. Additionally, when tobacco powder is added, the color of the oral composition or oral product tends to be the color of tobacco leaves. On the other hand, when a colorless nicotine-containing compound is used, it is possible to provide white compositions and oral products. Such an embodiment is an advantage for users who prefer white oral products. The above raw materials may be used alone or in combination of two or more.

The total nicotine content in the composition is not limited, but from the viewpoint of user preference, it is usually 0.1 to 5.0% by weight. The total nicotine content in the composition is usually 0.1% by weight or more, preferably 1.0% by weight or more, and more preferably 2.0% by weight or more. On the other hand, from the viewpoint of flavor, the total nicotine content in the composition is usually 5.0% by weight or less, preferably 4.0% by weight or less, and preferably 3.0% by weight or less. More preferred. Therefore, when using a nicotine-containing raw material as a plant-derived alkaloid, the amount of the raw material is adjusted so that the total nicotine content falls within this range. When nicotine exists as an ion, the above content rate is the content rate as a nicotine ion. The nicotine content in the composition can be measured using a gas chromatography mass spectrometer (GC-MS), liquid chromatography (LC, UV detection), or the like.

(3) pH adjuster The composition includes a pH adjuster. The pH adjuster is not limited, and those that are allowed to be added to foods are preferred. Examples include sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, potassium phosphate, anhydrous sodium phosphate, sodium dihydrogen phosphate, and sodium citrate. Among these, sodium phosphate, potassium carbonate, or sodium dihydrogen phosphate is preferred from the viewpoint of influence on product taste and product stability during storage. One type of pH adjuster may be used alone, or two or more types may be used in combination in any ratio.

(4) Gelling agent, gelling aid The composition may contain a known gelling agent and the like. When the product is taken into the oral cavity, the gelling agent alleviates the foreign body sensation caused by the nonwoven fabric, especially at the initial stage of taking the product, and gives a favorable impression to the user. The gelling agent is preferably a polysaccharide having a carboxyl group as a functional group, such as carrageenan, pectin, gum arabic, xanthan, gellan gum, or gum tragacanth. Furthermore, carrageenan, pectin, and gellan gum are preferred from the viewpoint of being easily gelled in the presence of calcium ions and being able to form a crosslinked structure by creating a junction zone with carboxyl groups and cations. One type of these may be used alone, or two or more types may be used in combination in any ratio.

Examples of gelation auxiliary components include calcium ions, and the source thereof (gelation auxiliary agent) is not limited, but includes, for example, calcium halogenates (chlorides, etc.), citric acid, carbonates, sulfuric acid, etc. Examples include salts, phosphates, lactates, and the like. Among these, calcium lactate, calcium chloride, or calcium phosphate is preferable from the viewpoint of having little influence on taste, high solubility, and pH after dissolution, and calcium lactate is particularly preferable. One type of these may be used alone, or two or more types may be used in combination in any ratio.

Examples of gelling auxiliary ingredients other than calcium ions include metal ions such as magnesium, silver, zinc, copper, gold, and aluminum, which can bind the gelling agent through ionic bonds in the same way as calcium ions, and highly cationic ions. Examples include molecular ions. Sources of these (other gelling aids) include, for example, halogenates (chlorides, etc.) of these metal ions, citric acid, carbonates, sulfates, phosphates, and cationic polymers. can be mentioned. One type of these may be used alone, or two or more types may be used in combination in any ratio.

(5) Mold release agent The composition may contain a known mold release agent. However, since the inorganic porous material, especially silica, also functions as a mold release agent, it is not necessary to contain any mold release agent other than the inorganic porous material.

(6) Water The water content (water content) in the composition is 15% by weight or more in one embodiment from the viewpoint of ease of manufacturing the composition. Furthermore, from the viewpoint of improving production efficiency, improving caking resistance, and suppressing stickiness of the composition, the lower limit of the water content is preferably 30% by weight or more, more preferably 45% by weight or more; The upper limit is usually 60% by weight or less, preferably 50% by weight or less. Further, the water content may be 40% by weight or less, 30% by weight or less, or 20% by weight or less. The water content can be adjusted by adjusting the amount of water added or by providing heat treatment or drying treatment at the manufacturing stage. The water content of the composition may be adjusted as appropriate depending on the type of product (moist or dry). For example, in the case of a moist type, the water content is usually 20 to 60% by weight, preferably 30 to 50% by weight. On the other hand, in the case of a dry type, the water content is usually 5 to 20% by weight, preferably 10 to 15% by weight.

The water content (moisture content) of the composition can be measured using a heat-drying moisture meter (for example, METTER manufactured by TOLEDO: HB 43-S). For measurement, a sample is placed in a predetermined container and heated to an ultimate temperature of 100°C. The measurement ends when the amount of change becomes 1 mg or less in 60 seconds, and the moisture content is calculated from the weighed values before and after heating.

(7) Others The composition may contain other substances in addition to the above. Other substances include, for example, fragrances, sweeteners, humectants, bitterness suppressants, emulsifiers, and the like. The content of the substance is not limited, and the formulation can be adjusted as appropriate depending on the product design.

1) Flavors Flavors are not limited, and examples include menthol, leaf tobacco extract, natural plant flavors (for example, cinnamon, sage, herbs, chamomile, kudzu grass, sweet tea, cloves, lavender, cardamom, cloves, nutmeg, bergamot, and geranium). , honey essence, rose oil, lemon, orange, cinnamon bark, caraway, jasmine, ginger, coriander, vanilla extract, spearmint, peppermint, cassia, coffee, celery, cascarilla, sandalwood, cocoa, ylang ylang, fennel, anise, licorice, St. John's bread, plum extract, peach extract, etc.), sugars (e.g., glucose, fructose, isomerized sugar, caramel, honey, molasses, etc.), cocoa (powder, extract, etc.), esters (e.g., isoamyl acetate) , linalyl acetate, isoamyl propionate, linalyl butyrate, etc.), ketones (e.g., menthone, ionone, damascenone, ethylmaltol, etc.), alcohols (e.g., geraniol, linalool, anethole, eugenol, etc.), aldehydes (e.g., vanillin) , benzaldehyde, anisaldehyde, etc.), lactones (e.g., γ-undecalactone, γ-nonalactone, etc.), animal fragrances (e.g., musk, ambergris, civet, castoreum, etc.), and hydrocarbons (e.g., limonene, etc.). , pinene, etc.). One type of fragrance may be used alone, or two or more types may be used in combination in any ratio.

2) Sweeteners Examples of sweeteners include, but are not limited to, sugar alcohols such as xylitol, maltitol, and erythritol; and acesulfame potassium, sucralose, and aspartame. Sugar alcohols are preferred from the viewpoint of taste adjustment. One type of sweetener may be used alone, or two or more types may be used in combination in any ratio.

The type of sugar alcohol is not particularly limited, and examples include xylitol, maltitol, erythritol, sorbitol, mannitol, and lactitol. Among these, maltitol is preferred from the viewpoint of imparting good flavor. One type of these substances may be used alone, or two or more types may be used in combination in any ratio.

The content of sugar alcohols in the composition (if it contains two or more types of sugar alcohols, their total content) is not limited, but from the perspective of flavor adjustment, it is usually 1% by weight or more, and the amount of % or more, more preferably 10% by weight or more. Further, the upper limit thereof is usually 80% by weight or less, preferably 70% by weight or less, and more preferably 60% by weight or less.

3) Bitter taste suppressor The bitter taste suppressor is not limited, but includes, for example, soybean lecithin. Soybean lecithin is a phospholipid, and specific examples include phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid. As a bitter taste suppressant, one type may be used alone, or two or more types may be used in combination in any ratio.

4) Moisturizer Moisturizers are not limited, but include, for example, polyhydric alcohols such as glycerin and propylene glycol. From the viewpoint of product preservability, glycerin is preferred. As a humectant, one type may be used alone, or two or more types may be used in combination in any ratio.

5) Emulsifier, surfactant Emulsifiers are not limited, but examples include emulsifiers added to foods. Examples of the emulsifier include one or more selected from the group consisting of sucrose fatty acid ester, organic acid glycerin fatty acid ester, polyglycerin fatty acid ester, and lecithin. Examples of sucrose fatty acid esters include sucrose palmitate and sucrose stearate. Examples of the organic acid glycerin fatty acid ester include succinic acid glycerin fatty acid ester and diacetyl tartrate glycerin fatty acid ester. As the polyglycerin fatty acid ester, decaglycerin fatty acid ester can be mentioned. The content of the emulsifier in the composition is preferably such that the total content of the emulsifier and the aforementioned polyglycerol fatty acid ester falls within the range described above as the content of the polyglycerol fatty acid ester.

The degree of polymerization of glycerin in the polyglycerin fatty acid ester is preferably 2 to 10. Polyglycerol fatty acid ester functions as an emulsifier. Therefore, by containing the polyglycerol fatty acid ester, the components of the composition can be kept in a uniformly mixed state, and the flavor components can be kept stable, so that the flavor of the composition can be improved. In addition, the polyglycerin fatty acid ester can impart appropriate viscosity to the composition and bind each component together, so it can suppress the dryness of the composition and improve the feeling of use, flavor, etc. can. In addition, even if the composition is a dry type with a low water content (moisture content), it is possible to prevent the composition from scattering when filling an exterior material such as a pouch with the composition. In this way, by including the polyglycerol fatty acid ester in the composition, production efficiency such as work efficiency and yield in producing oral products can be improved.

Polyglycerin fatty acid ester is a fatty acid ester of a dehydrated condensate of glycerin, and the degree of polymerization of glycerin is usually 2 or more, and may be 3 or more, and is usually 10 or less, and 8 or less. good.

The fatty acid ester group (RCOO- group) of polyglycerol fatty acid ester is derived from a fatty acid. The fatty acid is not limited and may be a saturated fatty acid or an unsaturated fatty acid. In addition, from the viewpoint of good flavor and production efficiency, the number of carbon atoms in the fatty acid is usually 10 or more, preferably 12 or more, more preferably 14 or more, and even more preferably 16 or more. Moreover, it is usually 30 or less, preferably 26 or less, more preferably 22 or less, and even more preferably 20 or less. The fatty acid may have a substituent or may be unsubstituted.

In addition, the number of fatty acid ester groups that one molecule of polyglycerol fatty acid ester has is not limited as long as the polyglycerol fatty acid ester has a structure that can function as an emulsifier, and depends on the degree of polymerization of glycerin and the number of hydroxyl groups derived from glycerin. It can be selected as appropriate. A structure that can function as an emulsifier is a structure that has both a fatty acid moiety that serves as a lipophilic group and a polyhydric alcohol moiety that serves as a hydrophilic group. Specifically, the number of fatty acid ester groups per molecule of polyglycerin fatty acid ester should normally be one or more. Further, the number of hydroxyl groups derived from glycerin may be one or more.

The degree of polymerization of glycerin and the type and number of fatty acid ester groups in the polyglycerin fatty acid ester can be arbitrarily combined as described above. More specifically, the alcohol component of the polyglycerin fatty acid ester may be diglycerin, triglycerin, tetraglycerin, pentaglycerin, hexaglycerin, heptaglycerin, octaglycerin, nonaglycerin, or decaglycerin. The acid component of the polyglycerol fatty acid ester may be a fatty acid such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, α-linolenic acid, and the like. Further, the polyglycerin fatty acid ester may be a monoester, diester, triester, tetraester, pentaester, or the like. As the polyglycerol fatty acid ester, one type may be used alone, or two or more types may be used in combination in any ratio.

From the viewpoint of good flavor and workability during production, the polyglycerin fatty acid ester is preferably one or more selected from diglycerin monofatty acid ester and decaglycerin fatty acid ester. The diglycerin monofatty acid ester is preferably selected from the group consisting of diglycerin monolaurate, diglycerin monomyristate, diglycerin monopalmitate, diglycerin monostearate and diglycerin monooleate; More preferred is oleate. The decaglycerin fatty acid ester is preferably selected from the group consisting of decaglycerin laurate, decaglycerin myristate, decaglycerin palmitate, decaglycerin stearate and decaglycerin oleate; More preferably it is selected from the group consisting of myristate, decaglycerin monopalmitate, decaglycerin monostearate and decaglycerin monooleate.

The content of polyglycerol fatty acid esters in the composition (if it contains two or more types of polyglycerol fatty acid esters, their total content) is not limited, but from the viewpoint of obtaining good flavor and improving production efficiency. , usually at least 0.1% by weight, preferably at least 0.2% by weight, more preferably at least 0.3% by weight, even more preferably at least 0.5% by weight. Further, the content of the polyglycerol fatty acid ester is usually 20.0% by weight or less, preferably 15.0% by weight or less, and 10.0% by weight or less, preferably 15.0% by weight or less, from the viewpoint of imparting appropriate viscosity to the composition. It is more preferably at most 8.0% by weight, even more preferably at most 8.0% by weight.

The HLB value of the polyglycerol fatty acid ester is not limited, but from the viewpoint of obtaining good flavor and improving production efficiency, it is usually 6.0 or more, preferably 7.0 or more, and usually 20.0 or less, preferably It is 18.0 or less, more preferably 16.0 or less.

(8) Characteristics of composition 1) pH
The pH of the composition is not limited, but from the viewpoint of influence on taste, it is usually 7.0 or higher, preferably 7.5 or higher, more preferably 8.0 or higher, and usually 10 or higher. .0 or less, preferably 9.5 or less, and more preferably 9.0 or less. The pH is a measured value at 25°C.

The pH of the composition at a measurement temperature of 25° C. is determined using a pH analyzer (for example, LAQUA F-72 flat ISFET pH electrode manufactured by Horiba), and 20 mL of water is added to 2 g of the composition, shaken for 10 minutes, It can be measured by measuring the supernatant liquid. For example, calibrate the equipment using phthalate pH standard solution (pH 4.01), neutral phosphate pH standard solution (pH 6.86), borate pH standard solution (pH 9.18) (all manufactured by Wako Pure Chemical Industries). It is preferable to perform three-point calibration using

2) Fluidity The oral composition according to this embodiment has excellent fluidity. Fluidity also serves as an index of the composition's viscosity, adhesion to manufacturing equipment, caking resistance, and stickiness. A composition with excellent fluidity has low adhesion to manufacturing equipment, low caking resistance, low stickiness, and is excellent in handleability. The fluidity of the composition is evaluated by relative comparison of shear stress values at a normal stress of 5.0 kPa at a measurement temperature of 22°C. The normal stress of 5.0 kPa is a value that assumes a pressure load applied to the composition due to its own weight during production, transportation, storage, etc., as a condition that may cause the composition to adhere to production equipment, caking, or stickiness. The shear stress is preferably 4.15 kPa or more, more preferably 4.20 kPa or more, even more preferably 4.25 kPa or more, and preferably 5.85 kPa or less, more preferably 5.80 kPa or less. The shear stress value of the composition, measured at a normal stress of 5.0 kPa, is preferably between 1.5 and 6 kPa.

The shear stress of the composition at the above normal stress of 5.0 kPa can be measured using a rheometer. For example, when a powder rheometer FT4 manufactured by Freeman Technology Co., Ltd. is used as a rheometer, the measurement is performed under the following measurement conditions.
Measurement mode: standard program (25mm_shear_9kPa)
Measurement temperature: 22℃
Measured humidity: 60%RH
Measuring container: Cylindrical container with an inner diameter of 25 mm, volume of 10 ml
Vertical load: 3-9kPa
Each raw material to be measured is passed through a sieve (1.18 mm opening) to make the particles fine and uniform, which is used as a measurement sample, and the measurement is performed according to the procedure of the rheometer described above.

3) Adhesion of the Composition As described above, the adhesion of the composition is indexed by the shear stress at a normal stress of 0 kPa at a measurement temperature of 22°C. The vertical stress of 0 kPa is the pressure applied when the pouch product is crushed in the thickness direction after the user puts it in the mouth and before saliva has soaked in. In other words, it is assumed that no pressure is applied in any direction other than this thickness direction. This is the numerical value.

Similar to the fluidity measurement above, the shear stress of the composition was measured at normal stresses of 3kPa, 4kPa, 5kPa, 6kPa, and 7kPa, and a graph was created by plotting the vertical stress on the horizontal axis and the shear stress on the vertical axis. do. Since the shear stress changes linearly with respect to the normal stress, this graph is fitted, and the shear stress at a normal stress of 0 kPa is calculated from the fitting result. The fitting conditions are shown below.
A first-order linear regression line is derived by calculation from each value of shear stress for each vertical stress (3 kPa, 4 kPa, 5 kPa, 6 kPa, 7 kPa). Calculate the value of its slope and Y-intercept. The value of the calculated Y-intercept is defined as the shear stress at a vertical stress of 0 kPa.

4) Flow Function
In the above adhesion evaluation, the Mohr stress circle was fitted to the linear line used to calculate the shear stress at a normal stress of 0 kPa, and the maximum principal stress and uniaxial collapse strength were determined, and the independent collapse strength The ratio of the maximum principal stress to the maximum principal stress (maximum principal stress/single collapse strength) can be calculated to evaluate the Flow Function.
The larger the value of Flow Function (FF), the higher the fluidity.

(9) Method for producing composition The composition can be produced by any method, but it is preferably produced through a step of mixing the base material, nicotine, and, if necessary, the above-mentioned components. Mixing can be performed by charging all raw materials into a mixer and mixing them.

In a preferred manufacturing method, first, the base material, nicotine, and optionally water and other substances (sweeteners, flavors, humectants, etc.) are mixed to obtain a first mixture. At this time, heating may be applied. Furthermore, the order of mixing each raw material is not limited, and they may be mixed in any order or at the same time by being added to the mixer, or solid raw materials may be mixed uniformly, then liquid raw materials may be added and further mixed. good. From the viewpoint of workability, the latter embodiment is preferable.

To the mixture obtained as above, an aqueous solution containing a pH adjuster, a sweetener such as acesulfame potassium, a flavoring agent such as menthol, a bitterness suppressant such as soybean lecithin, and a humectant such as glycerin are added as necessary (additives addition step). The above additives may be added in solid form or as an aqueous solution dissolved in water. When added in an aqueous solution, it may be added in advance by dissolving it in a predetermined amount of water to achieve the final moisture content of the oral product.

2. Oral Pouch Products Oral products are used by being placed in the mouth. Oral pouch products are compositions that contain a composition (also called the main material or filler) within a sealed water-insoluble packaging material (also called a pouch), and saliva penetrates through the pouch and is contained within the pouch. A product that dissolves the ingredients in the product and can then be passed through a pouch and transported into the oral cavity.

(1) Pouch Pouches are not limited to known pouches as long as they can package the filling, do not dissolve in water, and can permeate liquids (water, saliva, etc.) and water-soluble components in the filling. Can be used. Examples of the material for the pouch include cellulose nonwoven fabric, and commercially available nonwoven fabrics may also be used. A pouch product can be produced by forming a sheet made of such a material into a bag shape, filling the bag with a filler, and sealing the bag by means such as heat sealing.

The basis weight of the sheet is not particularly limited, and is usually 12 gsm (g/m ² ) or more and 54 gsm or less, preferably 24 gsm or more and 30 gsm or less. The thickness of the sheet is not particularly limited, and is usually 100 μm or more and 300 μm or less, preferably 175 μm or more and 215 μm or less.

At least one of the inner and outer surfaces of the pouch may be partially coated with a water-repellent material. A water-repellent fluororesin is suitable as the water-repellent material. Specifically, this type of water-repellent fluororesin includes Asahi Guard (registered trademark) manufactured by Asahi Glass Co., Ltd. Water-repellent fluororesins are applied to packaging materials for foods and products containing fats and oils, such as confectionery, dairy products, prepared foods, fast food, and pet food. Therefore, this type of water-repellent fluororesin is safe even when applied to pouches placed in the oral cavity. The water-repellent material is not limited to fluororesin, and may be a water-repellent material such as paraffin resin, silicone resin, or epoxy resin.

The pouch may contain any ingredients. Examples of such components include raw materials that adjust aroma and taste, fragrances, additives, tobacco extracts, and pigments. Furthermore, the manner in which these components are contained is not limited, and examples include methods in which they are applied to the surface of the pouch, impregnated, and in the case of fibers, they are contained in the fibers.

The appearance of the pouch is also not limited. Pouches may be non-transparent, translucent, or transparent. If the pouch is translucent or transparent, the filling can be seen through.

The size of the oral pouch product is not limited. The size of the product before use may be such that the lower limit of the long side is 25 mm or more, 28 mm or more, 35 mm or more, or 38 mm or more. Moreover, the upper limit may be 40 mm or less. The lower limit of the short side may be 10 mm or more or 14 mm or more. Moreover, the upper limit may be 20 mm or less or 18 mm or less. The ratio of the weight of the filler to the total weight of the oral pouch product is not limited, but is usually 80% by weight or more, preferably 85% by weight or more, more preferably 90% by weight or more, and , usually 99% by weight or less, preferably 97% by weight or less, more preferably 95% by weight or less.

(2) Filler The oral pouch product is filled with the composition as a filler. The amount of filler per oral pouch product is preferably between 0.4 and 1.5 g.

(3) Method for manufacturing oral pouch products Oral pouch products can be manufactured by packaging the composition with an exterior material (packaging process). The packaging method is not limited, and any known method can be applied. For example, a known method can be used, such as a method in which the composition is poured into a bag-shaped nonwoven fabric and then sealed. In the packaging process, desired additional water may be added after sealing (water addition process). For example, if the final composition has a water content of 50% by weight and the filled composition has a water content of 15% by weight, the remaining 35% by weight of water is added.

Embodiments will be described below.
Aspect 1
A porous material having an average particle size of 60 μm or more as a base material,
Contains nicotine and
In the porous material, the pore volume of pores having a pore diameter of 50 nm or more as measured by mercury intrusion porosimetry is 1.90 to 2.35 cm ³ /g.
Oral composition.
Aspect 2
the porous material is selected from the group consisting of silica, silicates, regenerated cellulose, and combinations thereof;
The oral composition according to aspect 1.
Aspect 3
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V3/(V1+V2+V3)≧50% by volume,
The oral composition according to aspect 1 or 2.
Aspect 4
The oral composition according to any one of aspects 1 to 4, having a water content of 15% by weight or more.
Aspect 5
The oral composition according to any one of aspects 1 to 5, comprising 6% by weight or more of the porous material.
Aspect 6
the porous material is an inorganic porous material selected from the group consisting of silica, silicates, and combinations thereof;
The average particle size of the inorganic porous material is 60 μm or more,
The oral composition according to any one of aspects 1 to 5.
Aspect 7
The inorganic porous material has a BET specific surface area of 200 to 1200 m ² /g.
The oral composition according to any one of aspects 1 to 6.
Aspect 8
The oral composition according to any one of aspects 1 to 7,
A packaging material for packaging the oral composition;
An oral pouch product comprising:

[Example 1] Production of oral composition As a base material, 100.0 g of silica (manufactured by Evonic, SIPERNAT2200), 3.87 g of nicotine, 45.1 g of anhydrous sodium phosphate aqueous solution, 4.79 g of anhydrous citric acid aqueous solution, 14.03 g of a sodium chloride aqueous solution and 23.4 g of an acesulfame K aqueous solution were added and mixed until homogeneous to obtain a mixture A. The obtained mixture A was subjected to jacket heating (can wall temperature: 100° C.). Thereafter, the mixture was cooled for 30 minutes at an ambient temperature of 20° C. to obtain a mixture B (11% water content after cooling). To the cooled mixture B, 67.7 g of tripotassium phosphate aqueous solution, 28.5 g of trisodium phosphate aqueous solution, 20 g of gellan gum aqueous solution, and other components were added to form an oral composition (water content 41.2% by weight, 263 g of pH 8.51) were obtained.

[Example 2]
An oral composition was produced in the same manner as in Example 1, except that 36.0 g of powdered cellulose (VITACEL L00, manufactured by Rettenmeyer) and 66.0 g of the silica were mixed and used as a base material.

[Example 3]
An oral composition was produced in the same manner as in Example 1, except that 100.0 g of granular regenerated cellulose (Visco Pearl Mini, manufactured by Rengo Co., Ltd.) was used as the base material.

[Comparative example 1]
An oral composition was produced in the same manner as in Example 1, except that 100.0 g of microcrystalline cellulose (VIVAPUR200, manufactured by Rettenmeyer) was used as the base material. Table 1 shows the composition, and Table 2 shows the physical properties of the base material.

The evaluation results of workability and fluidity during composition production in the above examples are shown below. The compositions obtained in the examples showed good fluidity. As mentioned above, the compositions of the examples have excellent fluidity and therefore are also excellent in handleability.
The evaluation indicators regarding yield and machine adhesion were as follows.
A: Good (excellent yield, excellent powder properties)
B: Inferior to A, but can be used in the subsequent pouching process. C: Cannot be used in the subsequent pouching process.

Various measurements were carried out as follows.
<Average particle size>
The average particle size of each material means the particle size (D50) at 50% cumulative volume based on the particle size distribution determined by laser diffraction particle size distribution measurement. Laser diffraction particle size distribution was measured using Mastersizer 3000 (manufactured by Malvern Panalytical).

<Water content>
It was measured using a heat drying moisture meter (METTER TOLEDO: HB 43-S). At the time of measurement, the sample was placed in a predetermined container and heated to an ultimate temperature of 100°C. The measurement was terminated when the amount of change became 1 mg or less in 60 seconds, and the water content was calculated from the weighed values before and after heating.

<Macropore analysis using mercury intrusion method>
Measurement was performed using a fully automatic pore distribution measuring device (PoreMaster 60-GT (manufactured by Quanta Chrome Co.)).

<pH>
Using a pH analyzer (manufactured by Horiba, Ltd.: LAQUA F-72 flat ISFET pH electrode), 20 ml of water was added to 2 g of the composition, shaken for 10 minutes, and the supernatant liquid was measured. For example, calibrate the equipment using phthalate pH standard solution (pH 4.01), neutral phosphate pH standard solution (pH 6.86), borate pH standard solution (pH 9.18) (all manufactured by Wako Pure Chemical Industries). This was done using a three-point calibration.

<Liquidity>
(shear stress)
The shear stress at a measurement temperature of 22° C. and a vertical stress (vertical load) of 3 to 7 kPa was measured using a rheometer (Powder Rheometer FT4 manufactured by Freeman Technology). The measurement conditions were as follows.
Measurement mode: standard program (25mm_shear_9kPa)
Measurement temperature: 22℃
Measured humidity: 60%RH
Measuring container: Cylindrical container with an inner diameter of 25 mm, volume of 10 ml
Vertical load: 3-7kPa
Each raw material to be measured was passed through a sieve (1.18 mm opening) to make the particles fine and uniform, which was used as a measurement sample, and measurement was performed according to the procedure of the rheometer described above. The shear stress under a vertical load of 5 kPa was used as an index of fluidity.

(Flow Function)
It was obtained as follows.
1) First, the shear stress at a normal stress of 0 kPa was determined as follows.
A graph was created by plotting the vertical stress on the horizontal axis and the shear stress on the vertical axis. Since the shear stress changes linearly with respect to the normal stress, this graph was fitted, and the shear stress at a normal stress of 0 kPa was calculated from the fitting result. The fitting conditions are shown below.
A first-order linear regression line is calculated from each value of shear stress for each vertical stress (3 kPa, 4 kPa, 5 kPa, 6 kPa, 7 kPa). The slope and Y-intercept values were calculated. The value of the calculated Y-intercept was taken as the shear stress at a vertical stress of 0 kPa.
2) Fit the Mohr stress circle to the above linear line, obtain the maximum principal stress and uniaxial collapse strength, calculate the ratio of the maximum principal stress to the independent collapse strength (maximum principal stress/single collapse strength), and Function. The larger the value of Flow Function (FF), the higher the fluidity.

Claims

A porous material having an average particle size of 60 μm or more as a base material,
Contains nicotine and
In the porous material, the pore volume of pores having a pore diameter of 50 nm or more as measured by mercury intrusion porosimetry is 1.90 to 2.35 cm 3 /g.
Oral composition.
the porous material is selected from the group consisting of silica, silicates, regenerated cellulose, and combinations thereof;
The oral composition according to claim 1.
The pore volume of pores with a pore diameter of less than 2 nm measured by the nitrogen adsorption method and calculated using the HK method is V1,
The pore volume of pores with a pore diameter of 2 nm or more and less than 50 nm, measured by the nitrogen adsorption method and calculated using the BJH method, is V2,
When the pore volume of pores with a pore diameter of 50 nm or more measured by mercury intrusion method is V3,
V3/(V1+V2+V3)≧50% by volume,
The oral composition according to claim 1 or 2.
The oral composition according to any one of claims 1 to 4, which has a water content of 15% by weight or more.
The oral composition according to any one of claims 1 to 5, comprising 6% by weight or more of the porous material.
the porous material is an inorganic porous material selected from the group consisting of silica, silicates, and combinations thereof;
The average particle size of the inorganic porous material is 60 μm or more,
The oral composition according to any one of claims 1 to 5.
The inorganic porous material has a BET specific surface area of 200 to 1200 m 2 /g.
The oral composition according to any one of claims 1 to 6.
The oral composition according to any one of claims 1 to 7,
A packaging material for packaging the oral composition;
An oral pouch product comprising: