WO2023207447A1 - Dérivé de pyrrolo[2,3-d]pyrimidine ou de pyrazolo[3,4-d]pyrimidine et son utilisation - Google Patents

Dérivé de pyrrolo[2,3-d]pyrimidine ou de pyrazolo[3,4-d]pyrimidine et son utilisation Download PDF

Info

Publication number
WO2023207447A1
WO2023207447A1 PCT/CN2023/083163 CN2023083163W WO2023207447A1 WO 2023207447 A1 WO2023207447 A1 WO 2023207447A1 CN 2023083163 W CN2023083163 W CN 2023083163W WO 2023207447 A1 WO2023207447 A1 WO 2023207447A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
atoms
group
mmol
alkyl
Prior art date
Application number
PCT/CN2023/083163
Other languages
English (en)
Chinese (zh)
Inventor
薛丁
黄俊鸿
徐挺洋
刘伟
Original Assignee
腾讯科技（深圳）有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 腾讯科技（深圳）有限公司 filed Critical 腾讯科技（深圳）有限公司
Publication of WO2023207447A1 publication Critical patent/WO2023207447A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Definitions

  • the present application relates to the field of medicine. Specifically, the present application relates to pyrrolo[2,3-d]pyrimidine or pyrazolo[3,4-d]pyrimidine derivatives as LSD1 inhibitors and their uses.
  • Histone lysine specific demethylase 1 is a member of the monoammonium oxidase family and uses flavin adenine dinucleotide (FAD) as a cofactor Catalyzes demethylation reactions. LSD1 can catalyze the demethylation of H3K4me1/2 and H3K9me1/2, thereby regulating the gene transcription process.
  • the epigenetic system in cells normally regulates physiological processes such as cell self-renewal, differentiation, and proliferation.
  • physiological processes such as cell self-renewal, differentiation, and proliferation.
  • this system is dysregulated, thereby promoting physiological processes such as the proliferation of cancer cells.
  • LSD1 has been found to be dysregulated and overexpressed in a variety of cancers, including acute myeloid leukemia, small cell lung cancer, breast cancer, colorectal cancer, etc. Especially those cancer types that show differentiation block, while knockout of LSD1 shows effects such as inducing differentiation and inhibiting proliferation in various cancer subtypes. Therefore, LSD1 inhibitors have good potential for clinical use in the treatment of various cancers.
  • LSD1 inhibitors studied in the early stage generally have the structure of phenylcypromine, which can covalently bind to flavin adenine dinucleotide (FAD) in the LSD1 aminooxidase domain (amine oxidase domain, AO), thus Irreversible inhibition of enzyme function.
  • FAD flavin adenine dinucleotide
  • AO amine oxidase domain
  • non-reversible LSD1 inhibitors may exhibit certain target-related toxicity.
  • irreversible LSD1 inhibitors including INCB-59872, Bomedemstat, GSK-2879552, ladademstat and Vafidemstat
  • irreversible LSD1 inhibitors covalently bind to FAD, which can easily affect embryonic stem cells and hematopoietic function, resulting in target-related side effects.
  • This application provides a reversible LSD1 inhibitor with a novel structure, which has high LSD1 inhibitory activity and can be used for the treatment of various hematological tumors and solid tumors.
  • This application proposes a compound, which is a stereoisomer, tautomer, deuterated product, nitrogen oxide, solvate, or metabolite of a compound represented by formula (I) or a compound represented by formula (I). , a pharmaceutically acceptable salt or its prodrug,
  • X 1 , X 2 , X 3 and X 4 are independently selected from C or N;
  • Y is -(CH 2 ) n -, O or N;
  • R 1 is a C 6-10 aryl group or a heteroaryl group composed of 5-10 atoms, wherein the C 6-10 aryl group and the heteroaryl group composed of 5-10 atoms are each independently unsubstituted or substituted by 1 , 2, 3 or 4 R′ replaced;
  • R 2 is H, deuterium, C 1-6 alkyl, C 3-12 carbocyclyl, C 3-12 carbocyclyl-C 1-4 alkylene, heterocyclyl composed of 3-12 atoms, ( Heterocyclyl composed of 3-12 atoms)-C 1-4 alkylene, C 6-10 aryl, C 6-10 aryl-C 1-4 alkylene, heterocyclic group composed of 5-14 atoms Aryl, (heteroaryl composed of 5-14 atoms)-C 1-4 alkylene, wherein the C 1-6 alkyl, C 3-12 carbocyclyl, C 3-12 carbocyclyl -C 1-4 alkylene group, heterocyclic group composed of 3-12 atoms, (heterocyclic group composed of 3-12 atoms) -C 1-4 alkylene group, C 6-10 aryl group, C 6 -10aryl -C 1-4 alkylene, heteroaryl group composed of 5-14 atoms, (heteroaryl group composed of 5-14
  • R 3 is H, deuterium, F, Cl, Br, CN, NO 2 , -OR a , -NR b R c , C 1-6 alkyl;
  • R a , R b , and R c are each independently H, deuterium, C 1-6 alkyl, C 1-6 haloalkyl, a heterocyclic group composed of 3-6 atoms, or R b , R c and connected to them The nitrogen atoms together form a heterocyclic ring composed of 3-6 atoms, wherein the C 1-6 alkyl group and the heterocyclic ring composed of 3-6 atoms are each independently unsubstituted or substituted by 1, 2, 3 or 4 Substituted with a substituent independently selected from deuterium, F, Cl, CN, OH, NH 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy or C 1-6 alkylamino;
  • n is an integer between 0 and 6.
  • the compound represented by formula (I) is a reversible LSD1 inhibitor with a novel structure and has high LSD1 inhibitory activity.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (II) or its prodrug:
  • Y, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 and R 3 have the definitions as described in this application.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (III) or its prodrug:
  • X 1 , X 2 , X 3 , X 4 , R 1 , R 2 and R 3 have the definitions as described in this application.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, and pharmaceutically acceptable salts of compounds having the structure shown in formula (IV) or its prodrug:
  • n 1 is 1, 2 or 3;
  • n1 0, 1, 2, 3 or 4;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (V) or its prodrug:
  • n 2 is 1, 2 or 3;
  • m2 is 0, 1, 2, 3 or 4 ;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, and pharmaceutically acceptable salts of compounds having the structure shown in formula (VI) or its prodrug:
  • n 3 is 1, 2 or 3;
  • m3 is 0, 1, 2, 3 or 4 ;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (VII) or its prodrug:
  • n 4 is 1, 2 or 3;
  • m4 is 0, 1, 2, 3 or 4 ;
  • X 5 and X 6 are independently C or N, and at least one of X 5 and X 6 is N;
  • X3 is C.
  • Y is empty, -(CH 2 )n-, O or N, wherein n is an integer between 1 and 6, and -(CH 2 )n- is unsubstituted or deuterated.
  • F, Cl, Br, CN, NO 2 , O, -OR a , -NR b R c substituted.
  • R 1 is a C 6-9 aryl group or a heteroaryl group composed of 5-9 atoms, wherein the C 6-9 aryl group and the heteroaryl group composed of 5-9 atoms are each independently Ground is unsubstituted or substituted by 1 or 2 R′.
  • R is H, deuterium, C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl-C 1-4 alkylene, 3-6 atoms Composed heterocyclyl, (heterocyclyl composed of 3-6 atoms)-C 1-4 alkylene, C 6-8 aryl, C 6-8 aryl-C 1-4 alkylene, 5 -Heteroaryl group composed of 8 atoms, (Heteroaryl group composed of 5-8 atoms)-C 1-4 alkylene group, wherein the C 1-6 alkyl group, C 3-6 carbocyclyl group, C 3-6 carbocyclyl-C 1-4 alkylene group, heterocyclyl group composed of 3-6 atoms, (heterocyclyl group composed of 3-6 atoms)-C 1-4 alkylene group, C 6 -8 aryl, C 6-8 aryl-C 1-4 alkylene, heteroaryl group composed of 5-8 atoms, (heterocyclyl group
  • R 3 is H, deuterium, F, Cl, Br, CN, NO 2 , -OH, -NH 2 or C 1-3 alkyl.
  • X 1 is C or N
  • X 2 is N
  • X 3 is C
  • X 4 is N
  • Y is O.
  • R is phenyl, naphthyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, 1,3, 5-triazinyl, thiazolyl, thienyl, pyrazinyl, pyridazinyl, pyrimidinyl, indolyl, purinyl, quinolyl, isoquinolyl, phenoxathiyl, wherein the phenyl , naphthyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, 1,3,5-triazinyl, thiazolyl, thienyl, Pyrazinyl, pyridazinyl, pyrimidin
  • R 2 is C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl-C 1-4 alkylene, heterocycle composed of 3-6 atoms base, (heterocyclyl composed of 3-6 atoms) -C 1-4 alkylene, wherein the C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl- C 1-4 alkylene group, heterocyclyl group composed of 3-6 atoms, (heterocyclyl group composed of 3-6 atoms)-C 1-4 alkylene group are each independently unsubstituted or substituted by 1, 2 Or replaced by 3 R′′.
  • R3 is F, Cl, or Br.
  • each R′′ is independently F, Cl, Br, -NR b R c .
  • R a , R b , R c are each independently H, deuterium, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, C 1-3 haloalkyl base, a heterocyclic group composed of 3-6 atoms or R b , R c and the nitrogen atoms connected to them together to form a heterocyclic ring composed of 3-6 atoms, wherein the methyl, ethyl, isopropyl , n-propyl, n-butyl, tert-butyl and a heterocyclic ring composed of 3-6 atoms are each independently unsubstituted or substituted by 1, 2 or 3 substituents, and the substituents are independently selected from deuterium , F, Cl, CN, OH, NH 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy or C
  • the present application relates to a conjugate, which includes a compound as described above, a connecting chain and a ubiquitin ligase E3 ligand, the connecting chain is disposed between the compound and the ubiquitin. Between the enzyme E3 ligands, the connecting chain is connected to the compound through chemical bonds, and the connecting chain is connected to the ubiquitin ligase E3 ligand through chemical bonds.
  • the present application relates to a pharmaceutical composition
  • a pharmaceutical composition comprising an effective amount of a compound as described above or a conjugate as described above.
  • the pharmaceutical composition further comprises: a pharmaceutically acceptable carrier, auxiliary agent, vehicle, or combinations thereof.
  • the pharmaceutical composition further comprises one or more therapeutic agents, wherein the therapeutic agents are selected from other anti-neoplastic drugs.
  • the therapeutic agent is an antimitotic drug, an alkylating agent, an antimetabolite drug, a topoisomerase inhibitor, an estrogen receptor modulator, an androgen receptor modulator, a protein kinase-targeting Small molecule inhibitors, antibody drugs targeting protein kinases.
  • the antimitotic drug is paclitaxel or vincristine.
  • the alkylating agent is cisplatin, oxaliplatin, carboplatin, or cyclophosphamide.
  • the antimetabolite is gemcitabine, 5-fluorouracil, or methotrexate.
  • the topoisomerase inhibitor is epipodophyllotoxin, etoposide, topotecan, or camptothecin.
  • the estrogen receptor modulator is tamoxifen or fulvestrant.
  • the androgen receptor modulator is bicalutamide.
  • the small molecule inhibitor targeting protein kinase is dasatinib, bosutinib, gefitinib, erlotinib, lapatinib, imatinib, Rotinib, sorafenib, tipifarnib, sunitinib, axitinib.
  • the protein kinase-targeting antibody drug is trastuzumab, panitumumab, or cetuximab.
  • the present application relates to the use of the aforementioned compound, the aforementioned conjugate or the aforementioned pharmaceutical composition in the preparation of a medicament, wherein the medicament is used for prevention, treatment, treatment or Alleviating diseases related to LSD1 overexpression or overactivity in patients.
  • the present application relates to the aforementioned compound, the aforementioned conjugate or the aforementioned pharmaceutical composition, for preventing, treating, treating or alleviating the overexpression or hyperactivity of LSD1 in patients. disease.
  • the present application relates to a method of preventing, treating, treating or alleviating a disease associated with overexpression or overactivity of LSD1 in a patient.
  • the method includes administering to the patient a pharmaceutically acceptable amount of the aforementioned compound, the aforementioned conjugate or the aforementioned pharmaceutical composition.
  • the disease associated with overexpression or overactivity of LSD1 is a tumor.
  • the tumor is papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, prostate cancer, or non-Hodgkin lymphoma.
  • the present application relates to the use of a compound as described above, a conjugate as described above, or a pharmaceutical composition as described above, for the preparation of a medicament, wherein the medicament is used to inhibit LSD1.
  • the present application relates to a compound as described above, a conjugate as described above, or a pharmaceutical composition as described above, for use in inhibiting LSD1.
  • the present application relates to a method of inhibiting LSD1.
  • the method comprises combining the aforementioned compound, the aforementioned conjugate or the aforementioned pharmaceutical composition. Apply to cells to be treated expressing LSD1.
  • this application includes all stereoisomers, geometric isomers, tautomers, solvates, hydrates, metabolites, salts and pharmaceutically acceptable prodrugs of the compounds of this application.
  • the salt refers to a pharmaceutically acceptable salt.
  • pharmaceutically acceptable means that the substance or composition must be chemically and/or toxicologically compatible with the other ingredients of the formulation and/or the mammal being treated therewith.
  • the compounds of the present application also include salt forms thereof, which salts are not necessarily pharmaceutically acceptable salts, but can be used to prepare and/or purify the compounds of the present application and/or to separate the enantiomers of the compounds of the present application. intermediate.
  • the compounds of the present application can also be obtained in the form of hydrates or include other solvents used for crystallization.
  • the compounds of the present application may inherently or by design form solvates with pharmaceutically acceptable solvents, including water; therefore, the present application also includes solvated and unsolvated forms thereof.
  • the compounds of the present application may contain several asymmetric centers or may be in the form of racemic mixtures as generally described.
  • the present application further includes racemic mixtures, partial racemic mixtures and isolated enantiomers and diastereomers.
  • the compounds of the present application may exist in one of the possible isomers, rotamers, atropisomers, tautomers or mixtures thereof.
  • the present application may further include isomers of the compounds of the present application. Mixtures of isomers, rotamers, atropisomers, tautomers, or partial mixtures or separations of isomers, rotamers, atropisomers, tautomers Isomers, rotamers, atropisomers, tautomers.
  • the present application relates to methods for the preparation, isolation and purification of compounds comprised by formula (I).
  • subject refers to an animal. Typically the animal is a mammal. Subjects also refer to primates (eg, humans), cattle, sheep, goats, horses, dogs, cats, rabbits, rats, mice, fish, birds, and the like. In certain embodiments, the subject is a primate. In yet other embodiments, the subject is human.
  • the terms “subject” and “patient” are used interchangeably.
  • the terms “subject” and “patient” refer to animals (e.g., birds such as chickens, quails, or turkeys, or mammals), particularly “mammals” including non-primates (e.g., cattle, pigs , horses, sheep, rabbits, guinea pigs, rats, cats, dogs, and mice) and primates (e.g., monkeys, chimpanzees, and humans), more particularly humans.
  • the subject is a non-human animal, such as a livestock (eg, horse, cow, pig, or sheep) or pet (eg, dog, cat, guinea pig, or rabbit).
  • "patient” refers to a human.
  • Stereochemical definitions and conventions used in this application are generally in accordance with S.P. Parker, Ed., McGraw-Hill Dictionary of Chemical Terms (1984) McGraw-Hill Book Company, New York; and Eliel, E. and Wilen, S., "Stereochemistry" of Organic Compounds," John Wiley & Sons, Inc., New York, 1994.
  • the compounds of the present application may contain asymmetric centers or chiral centers and therefore exist in different stereoisomeric forms. It is contemplated that all stereoisomeric forms of the compounds of the present application, including but not limited to diastereomers, enantiomers and atropisomers, and mixtures thereof such as racemic mixtures, are also included in the scope of this application.
  • optically active compounds that is, they have the ability to rotate the plane of plane polarized light.
  • the prefixes D and L or R and S are used to indicate the absolute configuration of the molecule with respect to the chiral center (or centers) in the molecule.
  • the prefixes d and l or (+) and (–) are symbols used to specify the rotation of plane-polarized light caused by a compound, where (–) or l indicates that the compound is levorotatory.
  • Compounds prefixed with (+) or d are dextrorotatory. For a given chemical structure, these stereoisomers are identical except that they are mirror images of each other.
  • stereoisomers may also be referred to as enantiomers, and mixtures of such isomers are often referred to as mixtures of enantiomers.
  • a 50:50 mixture of enantiomers is called a racemic mixture or racemate, which can occur when there is no stereoselectivity or stereospecificity in a chemical reaction or process. Spin body.
  • the compounds of the present application may exist in the form of one of the possible isomers or a mixture thereof, for example as a pure optical isomer, or as a mixture of isomers, such as racemic and non-racemic isomers.
  • Optically active (R)- or (S)-isomers can be prepared using chiral synthons or chiral preparations, or resolved using conventional techniques.
  • the substituent may be in the E or Z configuration; if the compound contains a disubstituted cycloalkyl group, the substituent of the cycloalkyl group may be cis or trans (cis- or trans-) structure.
  • the compounds of the present application may contain asymmetric centers or chiral centers and therefore exist in different stereoisomer forms. It is expected that the compounds of the present application All stereoisomeric forms, including but not limited to diastereoisomers, enantiomers and atropisomers and geometric (or conformational) isomers and mixtures thereof, such as racemates Mixtures are within the scope of this application.
  • structures described herein are also meant to include all isomeric (e.g., enantiomeric, diastereomeric atropisomer, and geometric (or conformational)) forms of the structure; for example, each R and S configurations of the asymmetric center, (Z) and (E) double bond isomers, and (Z) and (E) conformational isomers. Accordingly, individual stereochemical isomers as well as enantiomeric, diastereomeric, and geometric (or conformational) mixtures of the compounds of the present application are within the scope of the present application.
  • tautomer or "tautomeric form” refers to structural isomers with different energies that can be converted into each other through a low energy barrier. If tautomerism is possible (eg in solution), a chemical equilibrium of tautomers can be achieved.
  • protontautomers also known as prototropic tautomers
  • proton migration such as keto-enol isomerization and imine-enol isomerization. Amine isomerization.
  • Valence tautomers involve interconversions through the reorganization of some bonding electrons.
  • keto-enol tautomerism is the tautomerization of pentane-2,4-dione and 4-hydroxypent-3-en-2-one tautomers.
  • Another example of tautomerism is phenol-ketone tautomerism.
  • a specific example of phenol-keto tautomerism is the tautomerization of pyridin-4-ol and pyridin-4(1H)-one tautomers. Unless otherwise indicated, all tautomeric forms of the compounds of this application are within the scope of this application.
  • Deuterated compound refers to a compound in which one or more hydrogens of a compound are replaced by 2H .
  • nitrogen oxide means that when the compound contains several amine functional groups, one or more nitrogen atoms can be oxidized to form N-oxide.
  • N-oxides are N-oxides of tertiary amines or N-oxides of nitrogen atoms in nitrogen-containing heterocyclic rings.
  • the corresponding amine can be treated with an oxidizing agent such as hydrogen peroxide or a peracid such as peroxycarboxylic acid to form an N-oxide (see Advanced Organic Chemistry, Wiley Interscience, 4th edition, Jerry March, pages).
  • N-oxides can be prepared by the method of L.W. Deady (Syn. Comm. 1977, 7, 509-514), in which an amine compound is reacted with m-chloroperbenzoic acid (MCPBA), for example in an inert solvent, such as methylene chloride. reaction.
  • MCPBA m-chloroperbenzoic acid
  • Solvents that form solvates include, but are not limited to, water, isopropyl alcohol, ethanol, methanol, dimethyl sulfoxide, ethyl acetate, acetic acid, and aminoethanol.
  • hydrate refers to an association of solvent molecules with water.
  • Methodabolite refers to the product obtained by metabolism of a specific compound or its salt in the body.
  • the metabolites of a compound can be identified by techniques well known in the art, and its activity can be characterized by assays as described herein. Such products can be obtained by administering compounds through oxidation, reduction, hydrolysis, amidation, deamidation, esterification, delipidation, enzymatic cleavage, etc.
  • the present application includes metabolites of compounds, including metabolites produced by contacting a compound of the present application with a mammal for a sufficient period of time.
  • “Pharmaceutically acceptable salts” as used in this application refer to organic salts and inorganic salts of the compounds in this application.
  • Pharmaceutically acceptable salts are well known in the art, as documented in SM Berge et al., describe pharmaceutically acceptable salts in detail in J. Pharmaceutical Sciences, 1977, 66: 1-19.
  • Pharmaceutically acceptable non-toxic acid salts include, but are not limited to, inorganic acid salts formed by reaction with amino groups such as hydrochlorides, hydrobromides, phosphates, sulfates, perchlorates, And organic acid salts such as acetate, oxalate, maleate, tartrate, citrate, succinate, malonate, or by other methods recorded in books and literature, such as ion exchange method these salts.
  • salts include adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, and camphoric acid Salt, camphorsulfonate, cyclopentyl Propionate, digluconate, lauryl sulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemisulfate, Enanthate, caproate, hydroiodide, 2-hydroxy-ethanesulfonate, lactosuronate, lactate, laurate, lauryl sulfate, malate, malonate, formazanate Sulfonate, 2-naphthalene sulfonate, nicotinate, nitrate, oleate, palmitate, pamate, pectate, persulfate, 3-phenylpropionate, picrate
  • Salts obtained with appropriate bases include alkali metal, alkaline earth metal, ammonium and N + (C 1-4 alkyl) 4 salts. This application also contemplates the formation of quaternary ammonium salts of any compound containing an N group. Water-soluble or oil-soluble or dispersed products can be obtained by quaternization.
  • Alkali metal or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and others.
  • Pharmaceutically acceptable salts further include suitable, non-toxic ammonium, quaternary ammonium salts and amine cations that counter counter ion formation, such as halides, hydroxides, carboxylates, sulfates, phosphates, nitrates, C1 -8 Sulfonates and aromatic sulfonates.
  • prodrug used in this application represents a compound that is converted into a compound represented by formula (I) in vivo. Such conversion is affected by hydrolysis of the prodrug in the blood or enzymatic conversion to the parent structure in the blood or tissue.
  • the prodrug compounds of this application can be esters.
  • esters that can be used as prodrugs include phenyl esters, aliphatic (C 1-24 ) esters, acyloxy methyl esters, and carbonate esters. , carbamates and amino acid esters.
  • a compound in this application contains a hydroxyl group, which can be acylated to obtain a prodrug form of the compound.
  • prodrug forms include phosphate esters, which are obtained by phosphorylation of the hydroxyl group of the parent.
  • phosphate esters which are obtained by phosphorylation of the hydroxyl group of the parent.
  • prodrugs please refer to the following literature: T.Higuchi and V.Stella, Pro-drugs as Novel Delivery Systems, Vol.14 of the ACSSymposium Series, Edward B.Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press,1987,J.Rautio et al.,Prodrugs: Design and Clinical Applications,Nature Review Drug Discovery,2008,7,255-270,and SJHecker et al.,Prodrugs of Phosphates and Phosphonates,Journal of Medicinal Chemistry ,2008,51,2328-2345.
  • any asymmetric atom (e.g., carbon, etc.) of the compound of the present application may exist in a racemic or enantioenriched form, such as (R)-, (S)- or (R,S)-configuration.
  • each asymmetric atom has at least a 50% enantiomeric excess, at least a 60% enantiomeric excess, at least a 70% enantiomeric excess, in the (R)- or (S)-configuration, at least 80% enantiomeric excess, at least 90% enantiomeric excess, at least 95% enantiomeric excess, or at least 99% enantiomeric excess.
  • substituents on atoms with unsaturated double bonds may be present in the cis-(Z)- or trans-(E)-form.
  • the compounds of this application may exist in one form or a mixture thereof among possible isomers, rotamers, atropisomers, tautomers, For example, they may be substantially pure geometric (cis or trans) isomers, diastereomers, optical isomers (enantiomers), racemates or mixtures thereof.
  • Any resulting mixture of isomers may be separated into pure or substantially pure geometric or optical isomers, diastereomers, racemates on the basis of physicochemical differences of the components, for example by chromatography and/or separation. separation by crystallization.
  • racemate of the final product or intermediate may be resolved into its optical antipodes by known methods familiar to those skilled in the art, e.g., by subjecting the diastereomeric salts thereof obtained separation. Racemic products can also be separated by chiral chromatography, such as high-pressure liquid chromatography (HPLC) using chiral adsorbents.
  • HPLC high-pressure liquid chromatography
  • enantiomers can be prepared by asymmetric synthesis (eg, Jacques, et al., Enantiomers, Racemates and Resolutions (Wiley Interscience, New York, 1981); Principles of Asymmetric Synthesis ( 2nd Ed. Robert E.
  • the compounds of this application may be optionally substituted with one or more substituents, such as the compounds of the general formula above, or as specific examples in the examples, subclasses, and substituents contained in this application.
  • substituents such as the compounds of the general formula above, or as specific examples in the examples, subclasses, and substituents contained in this application.
  • a class of compounds may be used interchangeably with the term “substituted or unsubstituted”.
  • the terms “optionally”, “optionally” or “optionally” mean that the subsequently stated event or condition may but need not occur, and that the description includes instances in which the event or condition occurs as well as instances in which the event does not occur or situation.
  • the term “optionally”, whether or not preceded by the term “substituted,” means that one or more hydrogen atoms in a given structure are substituted with a specified substituent. Unless otherwise indicated, an optional substituent group may be substituted at each substitutable position of the group. When more than one position in a given structural formula can be substituted by one or more substituents selected from a specific group, the substituents may be identically or differently substituted at each position.
  • C 1-6 alkyl refers specifically to the independently disclosed methyl, ethyl, C 3 alkyl, C 4 alkyl, C 5 alkyl and C 6 alkyl.
  • linking substituents are described.
  • the Markush variables listed for that group should be understood as referring to the linking group.
  • the Markush group definition for that variable lists “alkyl” or “aryl,” it should be understood that the “alkyl” or “aryl” respectively represents the attached Alkylene group or arylene group.
  • alkyl or "alkyl group” as used in this application refers to a saturated linear or branched monovalent hydrocarbon radical containing 1 to 20 carbon atoms. Unless otherwise specified, an alkyl group contains 1 to 20 carbon atoms. In some embodiments, the alkyl group contains 1 to 10 carbon atoms. In other embodiments, the alkyl group contains 1 to 9 carbon atoms. Carbon atoms; in other embodiments, the alkyl group contains 1-8 carbon atoms, in other embodiments, the alkyl group contains 1-6 carbon atoms, in other embodiments, the alkyl group contains 1-4 carbon atoms. In other embodiments, the alkyl group contains 1-3 carbon atoms.
  • alkyl groups include, but are not limited to, methyl (Me, -CH 3 ), ethyl (Et, -CH 2 CH 3 ), n-propyl (n-Pr, -CH 2 CH 2 CH 3 ), isopropyl (i-Pr, -CH(CH 3 ) 2 ), n-butyl (n-Bu, -CH 2 CH 2 CH 2 CH 3 ), isobutyl (i-Bu, -CH 2 CH (CH 3 ) 2 ), sec-butyl (s-Bu, -CH(CH 3 )CH 2 CH 3 ), tert-butyl (t-Bu, -C(CH 3 ) 3 ), n-pentyl (-CH 2 CH 2 CH 2 CH 3 ), 2-pentyl (-CH(CH 3 )CH 2 CH 2 CH 3 ), 3-pentyl (-CH(CH 2 CH 3 ) 2 ), 2-methyl -2-butyl (-C(CH 3 ) 2
  • alkyl and its prefix “alkyl” include both straight and branched saturated carbon chains.
  • alkylene refers to a saturated divalent hydrocarbon radical obtained by removing two hydrogen atoms from a linear or branched saturated hydrocarbon radical. Unless otherwise specified, the alkylene group contains 1-10 carbon atoms. In some embodiments, the alkylene group contains 1-6 carbon atoms. In other embodiments, the alkylene group contains 1. -4 carbon atoms, in other embodiments the alkylene group contains 1-2 carbon atoms. Such examples include methylene (-CH 2 -), ethylene (-CH 2 CH 2 -), isopropylene (-CH(CH 3 )CH 2 -), and the like, wherein the alkylene group A group may independently be unsubstituted or substituted with one or more substituents described herein.
  • alkynyl means a linear or branched monovalent hydrocarbon group of 2 to 12 carbon atoms, or 2 to 8 carbon atoms, or 2 to 6 carbon atoms, or 2 to 4 carbon atoms, in which at least one Position CC is an sp triple bond unsaturated state, in which the alkynyl group can be independently unsubstituted or substituted by one or more substituents described in this application.
  • Specific examples include, but are not limited to, ethynyl ( -C ⁇ CH), propargyl (-CH 2 C ⁇ CH), 1-propynyl (-C ⁇ C-CH 3 ), etc.
  • alkoxy means an alkyl group attached to the remainder of the molecule through an oxygen atom, wherein the alkyl group has the meaning as described herein. Unless otherwise specified, the alkoxy group contains 1 to 20 carbon atoms, and in some embodiments, the alkoxy group contains 1 to 10 carbon atoms, and in other embodiments, the alkoxy group contains 1 to 10 carbon atoms. Containing 1-8 carbon atoms. In other embodiments, the alkoxy group contains 1-6 carbon atoms. In other embodiments, the alkoxy group contains 1-4 carbon atoms. In other embodiments, the alkoxy group contains 1-4 carbon atoms. Yes, the alkoxy group contains 1-3 carbon atoms.
  • alkoxy groups include, but are not limited to, methoxy (MeO,-OCH 3 ), ethoxy (EtO,-OCH 2 CH 3 ), 1-propoxy (n-PrO,n- Propoxy,-OCH 2 CH 2 CH 3 ), 2-propoxy (i-PrO,i-propoxy,-OCH(CH 3 ) 2 ), 1-butoxy (n-BuO,n- Butoxy,-OCH 2 CH 2 CH 2 CH 3 ), 2-methyl-l-propoxy (i-BuO,i-butoxy,-OCH 2 CH(CH 3 ) 2 ), 2-butyl Oxygen (s-BuO,s-butoxy,-OCH(CH 3 )CH 2 CH 3 ), 2-methyl-2-propoxy (t-BuO,t-butoxy,-OC(CH 3 ) 3 ), 1-pentyloxy (n-pentyloxy,-OCH 2 CH 2 CH 2 CH 2 CH 3 ), 2-pentyloxy (-OCH(CH 3 )
  • haloalkyl means an alkyl, alkenyl or alkoxy group substituted by one or more halogen atoms, examples of which include, but are not limited to, Trifluoromethyl, trifluoromethoxy, etc.
  • Carbocyclic refers to a non-aromatic ring containing 3 to 14 ring carbon atoms that is saturated or contains one or more unsaturated units. Carbocyclic system. In some embodiments, the number of carbon atoms is 3-12; in other embodiments, the number of carbon atoms is 3-10; in other embodiments, the number of carbon atoms is 3-8; In other embodiments, the number of carbon atoms is 5-6; in other embodiments, the number of carbon atoms is 6-8.
  • This "carbocyclyl” includes monocyclic, bicyclic or polycyclic fused, spiro or bridged carbocyclic ring systems, and also includes in which the carbocyclic ring may be combined with one or more non-aromatic carbocyclic or heterocyclic rings or one or more A polycyclic ring system in which aromatic rings or their combinations are fused, in which the connected atomic groups or points are on the carbocyclic ring.
  • Bicyclic carbocyclyl groups include bridged bicyclic carbocyclyl groups, fused bicyclic carbocyclyl groups and spiro bicyclic carbocyclyl groups. "fused" bicyclic carbocyclyl groups include two rings that share 2 adjacent ring atoms.
  • bridge double ring Groups include two rings sharing 3 or 4 adjacent ring atoms. Spiro ring systems share 1 ring atom.
  • Suitable carbocyclic groups include, but are not limited to, cycloalkyl, cycloalkenyl and cycloalkynyl.
  • carbocyclic groups further include, but are by no means limited to, cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopentyl-1-enyl, 1-cyclopentyl-2-enyl, 1- Cyclopentyl-3-enyl, cyclohexyl, 1-cyclohexyl-1-enyl, 1-cyclohexyl-2-enyl, 1-cyclohexyl-3-enyl, cyclohexadienyl, cycloheptyl base, cyclooctyl, cyclononyl, cyclodecyl, cycloundecyl, cyclododecyl, etc.
  • Bridged carbocyclyl groups include, but are not limited to, bicyclo[2.2.2]octyl, bicyclo[2.2.1]heptyl, bicyclo[3.3.1]nonyl, bicyclo[3.2.3]nonyl Key, wait.
  • cycloalkyl refers to a saturated, monocyclic, bicyclic or tricyclic ring system containing 3 to 12 ring carbon atoms with one or more points of attachment to the rest of the molecule.
  • the cycloalkyl group is a ring system containing 3-10 ring carbon atoms; in other embodiments, the cycloalkyl group is a ring system containing 3-8 ring carbon atoms; in other embodiments, the cycloalkyl group is a ring system containing 3-6 ring carbon atoms; in other embodiments, the cycloalkyl group is a ring system containing 5-6 ring carbon atoms; and the cycloalkyl group may be independently unsubstituted or substituted Substituted with one or more of the substituents described in this application.
  • heterocyclyl and “heterocycle” are used interchangeably herein and both refer to a saturated or partially unsaturated, nonaromatic monocyclic, bicyclic or tricyclic ring system containing 3 to 12 ring atoms, where At least one ring atom is selected from nitrogen, sulfur and oxygen atoms, and the ring system has one or more points of attachment to the rest of the molecule.
  • heterocyclyl includes monocyclic, bicyclic or polycyclic fused, spiro or bridged heterocyclic ring systems, and also includes systems in which the heterocyclic ring may be combined with one or more non-aromatic carbocyclic or heterocyclic rings or one or more A polycyclic ring system in which aromatic rings or their combinations are fused, in which the connected atomic groups or points are on the heterocyclic ring.
  • Bicyclic heterocyclyl groups include bridged bicyclic heterocyclyl groups, fused bicyclic heterocyclyl groups and spiro bicyclic heterocyclyl groups.
  • the sulfur atoms of the ring can optionally be oxidized to S-oxide.
  • the nitrogen atoms of the ring may optionally be oxidized to N-oxygen compounds.
  • the heterocyclyl group is a monocyclic or bicyclic heterocyclyl group composed of 3 to 8 atoms; in other embodiments, the heterocyclyl group is a monocyclic or bicyclic heterocyclyl group composed of 3 to 6 atoms.
  • the heterocyclyl group is a monocyclic or bicyclic heterocyclic group composed of 6-8 atoms; in some other embodiments, the heterocyclyl group is a heterocyclic group composed of 5-6 atoms; in some other embodiments, the heterocyclyl group is a heterocyclyl group composed of 4 atoms; in some other embodiments, the heterocyclyl group is a heterocyclyl group composed of 5 atoms; in some other embodiments, the heterocyclyl group is A heterocyclyl group composed of 6 atoms; in some other embodiments, the heterocyclyl group is a heterocyclyl group composed of 7 atoms; in some other embodiments, the heterocyclyl group is a heterocyclyl group composed of 8 atoms.
  • heterocyclyl groups include, but are not limited to: oxiranyl, azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl , pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, tetrahydrofuryl, dihydrofuranyl, tetrahydrothienyl, dihydrothienyl, 1,3-dioxopentyl, disulfide ring Pentyl, tetrahydropyranyl, dihydropyranyl, 2H-pyranyl, 4H-pyranyl, tetrahydrothiopyranyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl , dioxanyl, dithianyl, thioxanyl, homopiperazinyl, homopiperid
  • heterocyclyl groups in which the sulfur atom is oxidized include, but are not limited to, sulfolane groups and 1,1-dioxothiomorpholinyl groups.
  • Bridged heterocyclyl groups include, but are not limited to, 2-oxabicyclo[2.2.2]octyl, 1-azabicyclo[2.2.2]octyl, 3-azabicyclo[3.2.1]octyl Key, wait.
  • the heterocyclyl group may be optionally substituted with one or more substituents described herein.
  • bridge refers to a bond, atom, or an unbranched chain of atoms that connects two different parts of a molecule. Two atoms (usually but not always two tertiary carbon atoms) connected by a bridge are represented as "bridgeheads".
  • spiro refers to a ring system having one atom (usually a quaternary carbon atom) as the only shared atom between the two rings.
  • n atoms typically describes the number of ring-forming atoms in a molecule in which the number of ring-forming atoms is n.
  • piperidinyl is a heterocyclyl group composed of 6 atoms
  • 1,2,3,4-tetrahydronaphthyl is a carbocyclyl group composed of 10 atoms.
  • heteroatom refers to O, S, N, P and Si, including N, S and P in any oxidation state; in the form of primary, secondary, tertiary amines and quaternary ammonium salts; or on the nitrogen atom in a heterocyclic ring
  • the hydrogen is substituted, for example, N (like N in 3,4-dihydro-2H-pyrrolyl), NH (like NH in pyrrolidinyl) or NR (like N-substituted pyrrolidinyl) NR).
  • halogen refers to F, Cl, Br or I.
  • N 3 represents an azide structure. This group can be linked to other groups, for example to a methyl group to form methane azide (MeN 3 ) or to a phenyl group to form benzene azide (PhN 3 ).
  • cyano or "CN” refers to a cyano structure. This group can be linked to other groups.
  • nitro or " NO2 " refers to a nitro structure. This group can be linked to other groups.
  • aryl may be used alone or as a subset of “aralkyl”, “aralkoxy” or “aryloxyalkyl” to mean containing 6 to 14 ring atoms, or 6 to 12 rings. atoms, or monocyclic, bicyclic, and tricyclic carbocyclic ring systems of 6 to 10 ring atoms, of which at least one ring system is aromatic, and wherein each ring system contains a ring of 3 to 7 atoms, and There are one or more attachment points to the rest of the molecule.
  • aryl may be used interchangeably with the term “aromatic ring” or "aromatic ring”.
  • aromatic rings may include phenyl, naphthyl and anthracenyl.
  • the aryl groups may independently be unsubstituted or substituted with one or more substituents described herein.
  • heteroaryl may be used alone or as a subset of “heteroarylalkyl” or “heteroarylalkoxy” to mean containing 5 to 14 ring atoms, or 5 to 12 ring atoms, or Monocyclic, bicyclic, and tricyclic ring systems of 5 to 10 ring atoms, or 5 to 6 ring atoms, in which at least one ring system is aromatic and at least one ring system contains one or more heteroatoms, where each A ring system consists of a ring of 5-7 atoms with one or more points of attachment to the rest of the molecule.
  • the sulfur atoms of the ring can optionally be oxidized to S-oxide.
  • the nitrogen atoms of the ring may optionally be oxidized to N-oxygen compounds.
  • heteroaryl may be used interchangeably with the term “heteroaryl ring” or "heteroaromatic compound.”
  • the heteroaryl group is a heteroaryl group consisting of 5-12 atoms containing 1, 2, 3 or 4 heteroatoms independently selected from O, S and N.
  • the heteroaryl group is a heteroaryl group consisting of 5-10 atoms containing 1, 2, 3 or 4 heteroatoms independently selected from O, S and N. In other embodiments, the heteroaryl group is a heteroaryl group consisting of 5-6 atoms containing 1, 2, 3 or 4 heteroatoms independently selected from O, S and N. In other embodiments, the heteroaryl group is a 5-atom heteroaryl group containing 1, 2, 3, or 4 heteroatoms independently selected from O, S, and N. In other embodiments, the heteroaryl group is a 6-atom heteroaryl group containing 1, 2, 3, or 4 heteroatoms independently selected from O, S, and N.
  • the heteroaryl group includes the following monocyclic groups, but is not limited to these monocyclic groups: 2-furyl, 3-furyl, N-imidazolyl, 2-imidazolyl, 4-imidazole base, 5-imidazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, N-pyrrolyl , 2-pyrrolyl, 3-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, pyridazinyl (such as 3-pyridazine base), 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, tetrazolyl (such as 5H-tetrazolyl, 2H-tetrazolyl), triazolyl (such as 2-triazolyl),
  • 2-indine Dolkyl 2-indine Dolkyl
  • purinyl such as 2-quinolyl, 3-quinolyl, 4-quinolyl
  • isoquinolyl such as 1-isoquinolyl, 3-isoquinolyl) or 4-isoquinolyl
  • oxathyl The heteroaryl group is optionally substituted with one or more substituents described herein.
  • carboxy whether used alone or in combination with other terms, such as “carboxyalkyl”, means -CO 2 H;
  • alkylamino includes “N-alkylamino” and "N,N-dialkylamino” wherein the amino group is each independently substituted with one or two alkyl groups.
  • the alkylamino group is a lower alkylamino group with one or two C 1-6 alkyl groups attached to a nitrogen atom.
  • the alkylamino group is a C 1-3 lower alkylamino group.
  • Suitable alkylamino groups may be monoalkylamino or dialkylamino, examples of which include, but are not limited to, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N -diethylamino etc.
  • arylamino means that an amino group is substituted by one or two aryl groups, examples of which include, but are not limited to, N-phenylamino. In some embodiments, the aromatic ring on the arylamino group may be further substituted.
  • aminoalkyl includes C 1-10 straight or branched alkyl groups substituted with one or more amino groups.
  • the aminoalkyl group is a C 1-6 "lower aminoalkyl group" substituted by one or more amino groups.
  • Such examples include, but are not limited to, aminomethyl, amino Ethyl, aminopropyl, aminobutyl and aminohexyl.
  • the ring system formed by the substituent drawing a bond to the central ring represents that the substituent can be substituted at any substitutable position on the ring.
  • This ring system includes a monocyclic, bicyclic or polycyclic ring system.
  • conjugate refers to a compound formed by covalently linking a compound described in this application to biomolecules such as proteins, polypeptides, lipids, nucleic acids, antibodies, and other small molecules, such as PROTAC compound.
  • the "conjugate" described in the present application includes the compound described previously in the present application, a linker and a ubiquitin ligase E3 ligand, and the linker is provided on the compound and the ubiquitin ligase E3 ligand, the connecting chain is connected to the compound through a chemical bond, and the connecting chain is connected to the ubiquitin ligase E3 ligand through a chemical bond, thereby forming a "tribody” ligand.
  • the protein-proteasome pathway specifically degrades the target protein LSD1.
  • the term "pharmaceutically acceptable carrier” includes any solvent, dispersion medium, coating, surfactant, antioxidant, preservative (e.g., antibacterial, antifungal), isotonic agent, Salts, pharmaceutical stabilizers, binders, excipients, dispersants, lubricants, sweeteners, flavoring agents, colorants, or combinations thereof, these carriers are all known to those skilled in the art (such as Remington's Pharmaceutical Sciences, 18th Ed. Mack Printing Company, 1990, pp. 1289-1329). Except in the event that any conventional carrier is incompatible with the active ingredient, its use in a therapeutic or pharmaceutical composition is contemplated.
  • inhibiting LSD1 includes reducing the expression or activity of LSD1 (eg, reducing by at least 10%) and completely inhibiting the expression or activity of LSD1 (ie, 100% inhibiting the expression or activity of LSD1). In some embodiments, the expression or activity of LSD1 is inhibited by at least 50%, at least 65%, at least 75%, at least 85%, at least 90%, or at least 95%.
  • the term "effective amount" of a compound of the present application refers to an amount that elicits the desired biological response.
  • the expected biological response is to inhibit LSD1, prevent the recurrence, evolution, onset or progression of symptoms associated with LSD1 overexpression, or enhance or enhance the preventive or therapeutic effect of another anti-tumor therapy used.
  • the exact amount of compound administered to a subject will depend on the mode and severity of administration and characteristics of the subject, such as health, age, gender, weight, and tolerance to the drug. The skilled artisan will be able to determine the appropriate dosage based on these and other factors.
  • the "effective amount" of the second agent will depend on the type of drug used.
  • Suitable dosages of approved agents are known and can be adjusted by the skilled artisan depending on the condition of the subject, the type of condition being treated, and the amount of compound described herein used. Where the amount is not expressly stated, the effective amount should be taken.
  • the compounds described herein can be administered to a subject in a dosage range of about 0.01-100 mg/body weight/day for therapeutic or preventive treatment.
  • treatment refers to both therapeutic and preventive treatment.
  • therapeutic treatment includes alleviating or ameliorating the progression of LSD1 overexpression-mediated or hyperactive conditions resulting from the administration of one or more therapies (e.g., one or more therapeutic agents (e.g., compounds and compositions of the present application)) , severity and/or duration, or amelioration of one or more symptoms (in particular, one or more discernible symptoms) of a condition mediated by LSD1 overexpression or overactivity.
  • therapeutic treatment includes ameliorating at least one measurable physical parameter of a condition mediated by LSD1 overexpression or hyperactivity.
  • therapeutic treatment includes inhibiting progression of LSD1 overexpression-mediated or hyperactivity-mediated conditions, either physically, for example, by stabilizing discernible symptoms, or physiologically, for example, by stabilizing physical parameters, or both.
  • therapeutic treatment includes alleviating or stabilizing diseases mediated by LSD1 overexpression or overactivity, such as papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, Prostate cancer or non-Hodgkin lymphoma.
  • protecting group refers to a substituent that reacts with other functional groups, often to block or protect specific functionality.
  • amino protecting group refers to a substituent attached to the amino group to block or protect the functionality of the amino group in the compound. Suitable amino protecting groups include acetyl, trifluoroacetyl, and tert-butoxycarbonyl. (BOC,Boc), benzyloxycarbonyl (CBZ,Cbz) and 9-fluorenimethyleneoxycarbonyl (Fmoc).
  • hydroxyl protecting group refers to a substituent on a hydroxyl group that blocks or protects the functionality of the hydroxyl group.
  • Suitable protecting groups include acetyl and silyl groups.
  • Carboxyl protecting group refers to the substituent of the carboxyl group used to block or protect the functionality of the carboxyl group.
  • General carboxyl protecting groups include -CH 2 CH 2 SO 2 Ph, cyanoethyl, 2-(trimethylsilane ethyl), 2-(trimethylsilyl)ethoxymethyl, 2-(p-toluenesulfonyl)ethyl, 2-(p-nitrobenzenesulfonyl)ethyl, 2-(diphenyl Phosphino)ethyl, nitroethyl, etc.
  • protecting groups please refer to the literature: T W. Greene, Protective Groups in Organic Synthesis, John Wiley & Sons, New York, 1991; and PJ Kocienski, Protecting Groups, Thieme, Stuttgart, 2005.
  • This application provides a reversible LSD1 inhibitor with a novel structure, which has higher LSD1 inhibitory activity and can be used for the treatment of various hematological tumors and solid tumors.
  • This application proposes a compound, which is a stereoisomer, tautomer, deuterated product, nitrogen oxide, solvate, or metabolite of a compound represented by formula (I) or a compound represented by formula (I). , a pharmaceutically acceptable salt or its prodrug,
  • X 1 , X 2 , X 3 and X 4 are independently selected from C or N;
  • Y is -(CH 2 ) n -, O or N;
  • R 1 is a C 6-10 aryl group or a heteroaryl group composed of 5-10 atoms, wherein the C 6-10 aryl group and the heteroaryl group composed of 5-10 atoms are each independently unsubstituted or substituted by 1 , 2, 3 or 4 R′ replaced;
  • R 2 is H, deuterium, C 1-6 alkyl, C 3-12 carbocyclyl, C 3-12 carbocyclyl-C 1-4 alkylene, heterocyclyl composed of 3-12 atoms, ( Heterocyclyl composed of 3-12 atoms)-C 1-4 alkylene, C 6-10 aryl, C 6-10 aryl-C 1-4 alkylene, heterocyclic group composed of 5-14 atoms Aryl, (heteroaryl composed of 5-14 atoms)-C 1-4 alkylene, wherein the C 1-6 alkyl, C 3-12 carbocyclyl, C 3-12 carbocyclyl -C 1-4 alkylene group, heterocyclic group composed of 3-12 atoms, (heterocyclic group composed of 3-12 atoms) -C 1-4 alkylene group, C 6-10 aryl group, C 6 -10aryl -C 1-4 alkylene, heteroaryl group composed of 5-14 atoms, (heteroaryl group composed of 5-14
  • R 3 is H, deuterium, F, Cl, Br, CN, NO 2 , -OR a , -NR b R c , C 1-6 alkyl;
  • R a , R b , and R c are each independently H, deuterium, C 1-6 alkyl, C 1-6 haloalkyl, a heterocyclic group composed of 3-6 atoms, or R b , R c and connected to them The nitrogen atoms together form a heterocyclic ring composed of 3-6 atoms, wherein the C 1-6 alkyl group and the heterocyclic ring composed of 3-6 atoms are each independently unsubstituted or substituted by 1, 2, 3 or 4 Substituted with a substituent independently selected from deuterium, F, Cl, CN, OH, NH 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy or C 1-6 alkylamino;
  • n is an integer between 0 and 6.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (II) or its prodrug:
  • Y, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 and R 3 have the definitions as described in this application.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (III) or its prodrug:
  • X 1 , X 2 , X 3 , X 4 , R 1 , R 2 and R 3 have the definitions as described in this application.
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, and pharmaceutically acceptable salts of compounds having the structure shown in formula (IV) or its prodrug:
  • n 1 is 1, 2 or 3;
  • n1 0, 1, 2, 3 or 4;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (V) or its prodrug:
  • n 2 is 1, 2 or 3;
  • m2 is 0, 1, 2, 3 or 4 ;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, and pharmaceutically acceptable salts of compounds having the structure shown in formula (VI) or its prodrug:
  • n 3 is 1, 2 or 3;
  • m3 is 0, 1, 2, 3 or 4 ;
  • the present application relates to stereoisomers, tautomers, deuterated products, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts of compounds having the structure shown in formula (VII) or its prodrug:
  • n 4 is 1, 2 or 3;
  • m4 is 0, 1, 2, 3 or 4 ;
  • X 5 and X 6 are independently C or N, and at least one of X 5 and X 6 is N;
  • X3 is C.
  • Y is empty, -(CH 2 )n-, O or N, wherein n is an integer between 1 and 6, and -(CH 2 )n- is unsubstituted or deuterated.
  • F, Cl, Br, CN, NO 2 , O, -OR a , -NR b R c substituted.
  • R 1 is a C 6-9 aryl group or a heteroaryl group composed of 5-9 atoms, wherein the C 6-9 aryl group and the heteroaryl group composed of 5-9 atoms are each independently Ground is unsubstituted or substituted by 1 or 2 R′.
  • R is H, deuterium, C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl-C 1-4 alkylene, 3-6 atoms Composed heterocyclyl, (heterocyclyl composed of 3-6 atoms)-C 1-4 alkylene, C 6-8 aryl, C 6-8 aryl-C 1-4 alkylene, 5 -Heteroaryl group composed of 8 atoms, (Heteroaryl group composed of 5-8 atoms)-C 1-4 alkylene group, wherein the C 1-6 alkyl group, C 3-6 carbocyclyl group, C 3-6 carbocyclyl-C 1-4 alkylene group, heterocyclyl group composed of 3-6 atoms, (heterocyclyl group composed of 3-6 atoms)-C 1-4 alkylene group, C 6 -8 aryl, C 6-8 aryl-C 1-4 alkylene, heteroaryl group composed of 5-8 atoms, (heterocyclyl group
  • R 3 is H, deuterium, F, Cl, Br, CN, NO 2 , -OH, -NH 2 or C 1-3 alkyl.
  • X 1 is C or N
  • X 2 is N
  • X 3 is C
  • X 4 is N
  • X 1 is C
  • X 2 is N
  • X 3 is C
  • X 4 is N.
  • X 1 is N
  • X 2 is N
  • X 3 is C
  • X 4 is N
  • Y is O.
  • R is phenyl, naphthyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, 1,3, 5-triazinyl, thiazolyl, thienyl, pyrazinyl, pyridazinyl, pyrimidinyl, indolyl, purinyl, quinolyl, isoquinolyl, phenoxathiyl, wherein the phenyl , naphthyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, 1,3,5-triazinyl, thiazolyl, thienyl, Pyrazinyl, pyridazinyl, pyrimidin
  • R1 is phenyl, which is unsubstituted or is each independently substituted with 1 or 2 R'.
  • R1 is described Unsubstituted or each independently substituted by 1 or 2 R'.
  • R1 is described Unsubstituted or each independently substituted by 1 or 2 R'.
  • R1 is described Unsubstituted or each independently substituted by 1 or 2 R'.
  • R1 is described Unsubstituted or each independently substituted by 1 or 2 R'.
  • R 2 is C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl-C 1-4 alkylene, heterocycle composed of 3-6 atoms base, (heterocyclyl composed of 3-6 atoms) -C 1-4 alkylene, wherein the C 1-6 alkyl, C 3-6 carbocyclyl, C 3-6 carbocyclyl- C 1-4 alkylene group, heterocyclyl group composed of 3-6 atoms, (heterocyclyl group composed of 3-6 atoms)-C 1-4 alkylene group are each independently unsubstituted or substituted by 1, 2 Or replaced by 3 R′′.
  • R2 is described Unsubstituted or substituted by 1, 2 or 3 R′′.
  • R2 is described Unsubstituted or substituted by 1, 2 or 3 R′′.
  • R2 is methyl, which is unsubstituted or substituted with 1, 2, or 3 R′′.
  • R2 is described Unsubstituted or substituted by 1, 2 or 3 R′′.
  • R2 is described Unsubstituted or substituted by 1, 2 or 3 R′′.
  • R2 is described Unsubstituted or substituted by 1, 2 or 3 R′′.
  • R3 is F, Cl, or Br.
  • R3 is F.
  • each R′′ is independently F, Cl, Br, -NR b R c .
  • R1 is N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl
  • R2 is N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl
  • R a , R b , R c are each independently H, deuterium, methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, C 1-3 haloalkyl base, a heterocyclic group composed of 3-6 atoms or R b , R c and the nitrogen atoms connected to them together form a heterocyclic ring composed of 3-6 atoms, wherein the methyl, ethyl, isopropyl , n-propyl, n-butyl, tert-butyl and a heterocyclic ring composed of 3-6 atoms are each independently unsubstituted or substituted by 1, 2 or 3 substituents, the substituents are independently selected from deuterium , F, Cl, CN, OH, NH 2 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy or C 1-6 al
  • the present application relates to a compound having one of the following structures, or their stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable accepted salt or its prodrug.
  • the present application relates to a conjugate, which includes a compound as described above, a linking chain and a ubiquitin ligase E3 ligand, the linking chain being disposed between the compound and the ubiquitin.
  • the connecting chain is connected to the compound through chemical bonds, and the connecting chain is connected to the ubiquitin ligase E3 ligand through chemical bonds.
  • the present application relates to a pharmaceutical composition
  • a pharmaceutical composition comprising an effective amount of a compound as described above or a conjugate as described above.
  • the pharmaceutical composition further comprises: a pharmaceutically acceptable carrier, auxiliary agent, vehicle, or combinations thereof.
  • the pharmaceutical composition further comprises one or more therapeutic agents, wherein the therapeutic agents are selected from other anti-neoplastic drugs.
  • the therapeutic agent is an antimitotic drug, an alkylating agent, an antimetabolite drug, a topoisomerase inhibitor, an estrogen receptor modulator, an androgen receptor modulator, a protein kinase-targeting Small molecule inhibitors, antibody drugs targeting protein kinases.
  • the antimitotic drug is paclitaxel or vincristine.
  • the alkylating agent is cisplatin, oxaliplatin, carboplatin, or cyclophosphamide.
  • the antimetabolite is gemcitabine, 5-fluorouracil, or methotrexate.
  • the topoisomerase inhibitor is epipodophyllotoxin, etoposide, topotecan, or camptothecin.
  • the estrogen receptor modulator is tamoxifen or fulvestrant.
  • the androgen receptor modulator is bicalutamide.
  • the small molecule inhibitor targeting protein kinase is dasatinib, bosutinib, gefitinib, erlotinib, lapatinib, imatinib, Rotinib, sorafenib, tipifarnib, sunitinib, axitinib.
  • the protein kinase-targeting antibody drug is trastuzumab, panitumumab, or cetuximab.
  • the present application relates to the use of the aforementioned compound, the aforementioned conjugate or the aforementioned pharmaceutical composition in the preparation of a medicament, wherein the medicament is used for prevention, treatment, treatment or Alleviating diseases related to LSD1 overexpression or overactivity in patients.
  • the LSD1 overexpression-related disease is a tumor.
  • the tumor is papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, prostate cancer, or non-Hodgkin lymphoma.
  • the present application relates to the use of a compound as described above, a conjugate as described above, or a pharmaceutical composition as described above, for the preparation of a medicament, wherein the medicament is used to inhibit LSD1.
  • the present application relates to a method of preventing, treating, treating, or alleviating a disease associated with overexpression or overactivity of LSD1 in a patient.
  • the method includes administering to the patient a pharmaceutically acceptable dose of the aforementioned compound, the aforementioned conjugate, or the aforementioned pharmaceutical composition.
  • the salt refers to a pharmaceutically acceptable salt.
  • pharmaceutically acceptable means that the substance or composition must be chemically and/or toxicologically compatible with the other ingredients of the formulation and/or the mammal being treated therewith.
  • the compounds of the present application also include other salts of such compounds, which are not necessarily pharmaceutically acceptable salts, and can be used for the preparation and/or purification of the compounds of the present application and/or for the isolation of the compounds of the present application.
  • Intermediates of enantiomers are not necessarily pharmaceutically acceptable salts, and can be used for the preparation and/or purification of the compounds of the present application and/or for the isolation of the compounds of the present application.
  • Pharmaceutically acceptable acid addition salts can be formed with inorganic and organic acids, such as acetates, aspartates, benzoates, benzenesulfonates, bromides/hydrobromides, bicarbonates/ Carbonate, bisulfate/sulfate, camphorsulfonate, chloride/hydrochloride, chlorophylline salt, citrate, ethanedisulfonate, fumarate, glucoheptonate, glucosamine Conate, Glucuronate, Hippurate, Hydroiodide/Iodide, Isethionate, Lactate, Lacturonate, Lauryl Sulfate, Malate, Maleate Acid salt, malonate, mandelate, methanesulfonate, methyl sulfate, naphthoate, naphthalene sulfonate, nicotinate, nitrate, stearic acid Salt, oleate, oxalate, palmitate, pa
  • Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like.
  • Organic acids from which salts may be derived include, for example, acetic acid, propionic acid, glycolic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, mandelic acid, methanesulfonic acid , ethanesulfonic acid, p-toluenesulfonic acid, sulfosalicylic acid, etc.
  • Pharmaceutically acceptable base addition salts can be formed with inorganic and organic bases.
  • Inorganic bases from which salts can be derived include, for example, ammonium salts and metals from Groups I to XII of the Periodic Table.
  • the salts are derived from sodium, potassium, ammonium, calcium, magnesium, iron, silver, zinc and copper; particularly suitable salts include ammonium, potassium, sodium, calcium and magnesium salts.
  • Organic bases from which salts may be derived include primary, secondary and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like.
  • Certain organic amines include, for example, isopropylamine, benzathine, cholinate, diethanolamine, diethylamine, lysine, meglumine, piperazine, and tromethamine .
  • the pharmaceutically acceptable salts of the present application can be synthesized from the parent compound, basic or acidic moieties using conventional chemical methods.
  • such salts can be obtained by reacting the free acid forms of these compounds with a stoichiometric amount of a suitable base (such as Na, Ca, Mg or K hydroxides, carbonates, bicarbonates, etc.) or by The free base forms of these compounds are prepared by reacting a stoichiometric amount of the appropriate acid.
  • a suitable base such as Na, Ca, Mg or K hydroxides, carbonates, bicarbonates, etc.
  • Such reactions are usually carried out in water or organic solvents or a mixture of the two.
  • non-aqueous media such as diethyl ether, ethyl acetate, ethanol, isopropanol or acetonitrile will be used.
  • the compounds of the present application can also be obtained in the form of hydrates or include other solvents used for crystallization thereof.
  • the compounds of the present application may inherently or by design form solvates with pharmaceutically acceptable solvents, including water; thus, the present application is intended to include both solvated and unsolvated forms.
  • Isotopically labeled compounds have a structure depicted by the general formula given herein, except that one or more atoms are replaced by atoms of a selected atomic weight or mass number.
  • Exemplary isotopes that may be incorporated into the compounds of the present application include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine and chlorine, such as 2 H, 3 H, 11 C, 13 C, 14 C, 15 N, 18 F , 31 P, 32 P, 36 S, 37 Cl or 125 I.
  • compounds described herein include compounds as defined herein labeled with various isotopes, for example, those compounds in which radioactive isotopes such as 3 H, 14 C and 18 F are present, or in which non-radioactive isotopes are present, Such as 2H and 13C .
  • isotopically labeled compounds can be used for metabolic studies (using 14 C), reaction kinetic studies (using for example 2 H or 3 H), detection or imaging techniques such as positron emission tomography (PET) or including drugs or substrates.
  • PET positron emission tomography
  • SPECT Single-photon emission computed tomography
  • 18 F-labeled compounds are particularly ideal for PET or SPECT studies.
  • Isotopically labeled compounds of formula (I) can be prepared by using appropriate isotopically labeled reagents instead of the originally used unlabeled reagents using conventional techniques familiar to those skilled in the art or as described in the examples and preparation procedures in this application.
  • substitution with heavier isotopes may provide certain therapeutic advantages resulting from greater metabolic stability. For example, this may result from increased half-life in vivo or reduced dosage requirements or improved therapeutic index.
  • deuterium in this context is regarded as the compound of formula (I) Daiji.
  • Isotope enrichment factors can be used to define the concentration of heavier isotopes, especially deuterium.
  • the term "isotopic enrichment factor" as used herein refers to the ratio between the isotopic abundance and the natural abundance of a specified isotope.
  • the compound has for each designated deuterium atom at least 3500 (52.5% deuterium incorporation at each designated deuterium atom), at least 4000 (60% deuterium incorporation), At least 4500 (67.5% deuterium incorporation), at least 5000 (75% deuterium incorporation), at least 5500 (82.5% deuterium incorporation), at least 6000 (90% deuterium incorporation), at least 6333.3 (95% deuterium incorporation) deuterium incorporation), an isotope enrichment factor of at least 6466.7 (97% deuterium incorporation), at least 6600 (99% deuterium incorporation), or at least 6633.3 (99.5% deuterium incorporation).
  • Pharmaceutically acceptable solvates herein include those in which the crystallization solvent may be isotopically substituted such as D2O , acetone- d6 , or DMSO- d6 .
  • the present application provides a conjugate, which includes the aforementioned compound, a connecting chain and a ubiquitin ligase E3 ligand, and the connecting chain is disposed between the compound and the ubiquitin ligase E3 ligand.
  • the connecting chain is connected to the compound through a chemical bond
  • the connecting chain is connected to the ubiquitin ligase E3 ligand through a chemical bond.
  • the present application provides a pharmaceutical composition, which includes an effective amount of a compound described in the present application or a stereoisomer or conjugate thereof.
  • the pharmaceutical composition further comprises at least one pharmaceutically acceptable carrier, diluent, adjuvant or vehicle, and optionally, other therapeutic and/or preventive ingredients.
  • the pharmaceutical composition includes an effective amount of at least one pharmaceutically acceptable carrier, diluent, adjuvant, or vehicle.
  • Pharmaceutically acceptable carriers may contain inert ingredients that do not unduly inhibit the biological activity of the compound.
  • a pharmaceutically acceptable carrier should be biocompatible, such as non-toxic, non-inflammatory, non-immunogenic, or have no other adverse effects or side effects once administered to a patient. Standard pharmaceutical techniques can be used.
  • the pharmaceutical composition or pharmaceutically acceptable composition described in this application further includes a pharmaceutically acceptable carrier, adjuvant or excipient, as used in this application, including those suitable for specific Any solvent, diluent, liquid excipient, dispersant, suspending agent, surfactant, isotonic agent, thickener, emulsifier, preservative, solid binder or lubricant, etc. .
  • substances that may be used as pharmaceutically acceptable carriers include, but are not limited to, ion exchangers, aluminum oxide, aluminum stearate, lecithin, serum proteins (e.g., human serum albumin), buffer substances (e.g., Tween 80 , phosphate, glycine, sorbic acid or potassium sorbate), mixtures of partial glycerides of saturated vegetable fatty acids, water, salts or electrolytes (e.g.
  • protamine sulfate disodium hydrogen phosphate, potassium hydrogen phosphate, sodium chloride or zinc salts
  • silica gel silica gel
  • magnesium trisilicate polyvinylpyrrolidone
  • polyacrylates waxes
  • polyethylene-polyoxypropylene-block copolymer methylcellulose, hydroxypropylmethylcellulose, lanolin, sugars (e.g.
  • lactose glucose and sucrose
  • starch such as corn starch and potato starch
  • cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate
  • powdered tragacanth malt
  • Gels talc
  • excipients such as cocoa butter and suppository waxes
  • oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil
  • glycols such as propylene glycol or polypropylene glycol) Ethylene glycol
  • esters such as ethyl oleate and ethyl laurate
  • agar buffers (such as magnesium hydroxide and aluminum hydroxide), alginic acid, pyrogen-free water, isotonic saline, Ringer's solution (Ringer's solution), ethanol and phosphate buffers and other non-toxic compatible slips
  • Lubricants such as sodium lauryl
  • the compounds, conjugates or compositions of the present application may be administered by any suitable means, depending on the severity of the disease being treated, orally, rectally, parenterally, intracisternally, intravaginally, intraperitoneally, topically (as by powder,
  • the above-described compounds and pharmaceutically acceptable compositions are administered to humans or other animals as ointments or drops), orally as oral or nasal sprays, or the like.
  • Liquid dosage forms for oral administration include, but are not limited to, pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs.
  • liquid dosage forms may contain inert diluents customary in the art, such as water or other solvents, solubilizers and emulsifiers, such as ethanol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate Esters, propylene glycol, 1,3-butanediol, dimethylformamide, oils (especially cottonseed oil, peanut oil, corn oil, germ oil, olive oil, castor oil and sesame oil), glycerin, tetrahydrofurfuryl alcohol, poly Fatty acid esters of ethylene glycol and sorbitan and mixtures thereof.
  • the oral compositions can also include adjuvants such as we
  • Injectable preparations may be formulated according to known techniques using suitable dispersing or wetting agents and suspending agents, for example, sterile injectable aqueous or oily suspensions.
  • the sterile injectable preparation may also be a sterile injectable solution, suspension, or emulsion in a nontoxic parenterally acceptable diluent or solvent, such as a solution in 1,3-butanediol.
  • a nontoxic parenterally acceptable diluent or solvent such as a solution in 1,3-butanediol.
  • the acceptable vehicles and solvents that may be employed are water, Ringer's solution, U.S.P., and isotonic sodium chloride solution.
  • sterile fixed oils as the solvent or suspending medium.
  • any odorless fixed oil may be employed including synthetic mono- or diglycerides.
  • fatty acids such as octadecenoic acid, are used in the preparation of injectables.
  • injectable preparations can be sterilized by filtration through a bacteria-retaining filter or by the addition of a sterilizing agent in the form of a sterile solid composition that is soluble or dispersible in sterile water or other sterile injectable medium prior to use.
  • Injectable depot forms are made by forming a matrix of microencapsules of the compound in biodegradable polymers such as polylactide-polyglycolic acid. Depending on the ratio of compound to polymer and the nature of the particular polymer employed, the rate of compound release can be controlled. Examples of other biodegradable polymers include polyorthoesters and polyanhydrides. Injectable depot formulations may also be prepared by entrapping the compound in liposomes or microemulsions that are compatible with body tissues.
  • compositions for rectal or vaginal administration are particularly suppositories prepared by mixing a compound described herein with a suitable non-irritating excipient or carrier, such as cocoa butter, polyethylene glycol or a suppository wax.
  • a suitable non-irritating excipient or carrier such as cocoa butter, polyethylene glycol or a suppository wax.
  • the carrier is solid at ambient temperature but liquid at body temperature and therefore melts in the rectal or vaginal cavity and releases the active compound.
  • Oral solid dosage forms include capsules, tablets, pills, powders and granules.
  • the active compound is mixed with at least one inert pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) a filler or bulking agent such as starch, lactose, sucrose , glucose, mannitol and silicic acid, b) binders such as carboxymethylcellulose, alginates, gels, polyvinylpyrrolidone, sucrose and gum arabic, c) humectants such as glycerol, d) disintegrants , such as agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates and sodium carbonate, e) solution retardants, such as paraffin, f) absorption accelerators, such as quaternary ammonium compounds, g) wetting agents, For example cetyl alcohol and glyceryl monostearate, h)
  • Solid compositions of a similar type may also be used as fillers in soft and hard gel capsules using excipients such as lactose or milk sugar and high molecular weight polyethylene glycols.
  • Solid dosage forms of tablets, dragees, capsules, pills and granules may be prepared with coating shells such as enteric coatings and other coatings well known in the pharmaceutical art. They may optionally contain opacifying agents and may also be of a composition such that the active ingredient is released only, optionally in a delayed manner, or preferably, in a certain part of the intestinal tract. Examples of embedding compositions that can be used include polymers and waxes. Similar types of solid compositions may also be used as fillers in soft and hard gel capsules using excipients such as lactose or milk sugar and high molecular weight polyethylene glycols.
  • the active compounds can also be in microencapsulated form with one or more of the above-mentioned excipients.
  • Solid dosage forms of tablets, dragees, capsules, pills and granules may be prepared with coating shells such as enteric coatings, controlled release coatings and other coatings well known in the pharmaceutical arts.
  • the active compound may be mixed with at least one inert diluent, such as sucrose, lactose or starch.
  • inert diluent such as sucrose, lactose or starch.
  • such dosage forms may also contain additional substances besides the inert diluent, such as tableting lubricants and other tableting aids, such as magnesium stearate and microcrystalline cellulose.
  • the dosage form may also contain buffering agents.
  • opacifying agents may optionally contain opacifying agents and may also be of a composition such that the active ingredient is released only, optionally in a delayed manner, or preferably, in a certain part of the intestinal tract.
  • embedding compositions include polymers and waxes.
  • Dosage forms for topical or transdermal administration of the compounds described herein include ointments, ointments, creams, lotions, gels, powders, solutions, sprays, inhalants, or patches.
  • the active compounds are combined under sterile conditions with a pharmaceutically acceptable carrier and any desired preservatives or buffers that may be required.
  • Ophthalmic preparations, ear drops and eye drops are also contemplated within the scope of this application.
  • the present application contemplates the use of skin patches with the added advantage of providing controlled delivery of compounds to the body.
  • Such dosage forms can be prepared by dissolving or dispersing the compound in an appropriate medium.
  • Absorption enhancers may also be used to increase the flux of compounds through the skin. The rate can be controlled by providing a rate controlling membrane or by dispersing the compound in a polymer matrix or gel.
  • compositions described herein may also be administered orally, parenterally, topically by inhalation spray, rectally, nasally, bucally, vaginally, or via an implantable kit.
  • parenteral as used herein includes, but is not limited to, subcutaneous, intravenous, intramuscular, intraarticular, intrasynovial, intrasternal, intrathecal, intrahepatic, intralesional, and intracranial injection or infusion techniques.
  • the composition is administered orally, intraperitoneally or intravenously.
  • Sterile injectable forms of the compositions described herein may be aqueous or oily suspensions. These suspensions may be prepared following techniques known in the art using suitable dispersing or wetting agents and suspending agents.
  • the sterile injectable preparation may also be a sterile injectable solution or suspension in a nontoxic parenterally acceptable diluent or solvent, such as a solution in 1,3-butanediol.
  • a nontoxic parenterally acceptable diluent or solvent such as a solution in 1,3-butanediol.
  • the acceptable vehicles and solvents which may be employed are water, Ringer's solution and isotonic sodium chloride solution.
  • fatty acids such as oleic acid and its glyceride derivatives are used in the preparation of injectables, as are natural pharmaceutically acceptable oils, especially in polyoxyethylated forms, such as olive oil or castor oil.
  • oils especially in polyoxyethylated forms, such as olive oil or castor oil.
  • These oil solutions or suspensions may also contain long-chain alcohol diluents or dispersants such as carboxymethyl cellulose or similar dispersants commonly used in the formulation of pharmaceutically acceptable dosage forms including emulsions and suspensions.
  • Other commonly used surfactants such as Tweens, Spans and other emulsifiers or bioavailability enhancers commonly used in the production of pharmaceutically acceptable solid, liquid or other dosage forms may also be used for formulation purposes.
  • compositions described herein may be administered orally in any orally acceptable dosage form, including, but not limited to, capsules, tablets, aqueous suspensions, or solutions.
  • common carriers include, but are not limited to, lactose and starch.
  • a lubricant such as magnesium stearate is often added.
  • useful diluents include lactose and dried cornstarch.
  • aqueous suspensions are required for oral administration, the active ingredients are combined with emulsifying and suspending agents. If desired, certain sweetening, flavoring or coloring agents may also be added.
  • compositions described herein may be administered in the form of suppositories for rectal use.
  • These pharmaceutical compositions can be prepared by mixing the agent with a non-irritating excipient which is solid at room temperature but liquid at rectal temperature and will therefore melt in the rectum to release the drug.
  • a non-irritating excipient which is solid at room temperature but liquid at rectal temperature and will therefore melt in the rectum to release the drug.
  • Such substances include, but are not limited to, cocoa butter, beeswax, and polyethylene glycol.
  • compositions described herein may also be administered topically, particularly when the target of treatment involves topical application to an easily accessible area or organ, including eye, skin, or lower intestinal disease. Suitable topical formulations are readily prepared for each of these areas or organs.
  • Topical administration to the lower bowel may be achieved in the form of rectal suppositories (see above) or suitable enema formulations. Topical skin patches may also be used.
  • the pharmaceutical composition may be formulated as a suitable ointment containing the active ingredient suspended or dissolved in one or more carriers.
  • Carriers suitable for topical administration of compounds of the present application include, but are not limited to, mineral oil, petrolatum, white petrolatum, propylene glycol, polyoxyethylene, polyoxypropylene compounds, emulsifying waxes and water.
  • the pharmaceutical compositions may be formulated as a suitable lotion or cream containing the active ingredients suspended or dissolved in one or more pharmaceutically acceptable carriers.
  • Suitable carriers include, but are not limited to, mineral oil, sorbitan monostearate, polysorbate 60, cetyl ester wax, cetearyl alcohol, 2-octyldodecanol, benzyl alcohol, and water .
  • the pharmaceutical compositions are formulated as a micronized suspension in isotonic pH-adjusted sterile saline, or particularly as a solution in isotonic pH-adjusted sterile saline, with or without a preservative such as benzalkonium chloride.
  • the pharmaceutical composition may be formulated as an ointment, such as petroleum jelly.
  • compositions may also be administered via nasal aerosol spray or inhalation.
  • Such compositions are prepared according to techniques well known in the pharmaceutical arts and prepared in saline using benzyl alcohol and other suitable preservatives, absorption enhancers to enhance bioavailability, fluorocarbons and/or other conventional solubilizing or dispersing agents. solution.
  • unit dosage form refers to physically discrete units suitable as unitary dosages for subjects, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, optionally in association with a suitable pharmaceutical carrier.
  • the unit dosage form may be presented as a single daily dose or as one of multiple daily doses (eg, about 1 to 4 or more times per day). When multiple daily doses are used, the dosage unit form for each dose may be the same or different.
  • the above-mentioned compounds, conjugates and pharmaceutical compositions provided by this application can be used to prepare medicines for preventing, treating or alleviating LSD1 overexpression or hyperactivity-related diseases in patients.
  • the LSD1 overexpression or hyperactivity-related diseases is a tumor, for example, papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, prostate cancer or non-Hodgkin's lymphoma.
  • This application also provides the use of the above-mentioned compounds, conjugates or pharmaceutical compositions thereof in the preparation of drugs for inhibiting LSD1.
  • the present application provides a method for treating, preventing or delaying diseases caused by overexpression or overactivity of LSD1, which method includes administering a therapeutically effective amount of the above-mentioned compound, conjugate or pharmaceutical composition thereof to a patient in need of treatment.
  • the disease caused by overexpression or overactivity of LSD1 is a tumor, such as papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, prostate cancer or non-Hodgkin lymphoma .
  • the above-mentioned compounds, conjugates or pharmaceutical compositions thereof provided in this application can be co-administered with other therapies or therapeutic agents.
  • the administration can be simultaneous, sequential or at certain time intervals.
  • the dosage of a compound or pharmaceutical composition required to effect treatment, prevention or delay generally depends on the specific compound administered, the patient, the specific disease or condition and its severity, route and frequency of administration, etc., and needs to be determined by the attending physician. Determine specific circumstances. For example, when a compound or pharmaceutical composition provided herein is administered via the intravenous route, administration may occur once a week or even at longer intervals.
  • this application provides a novel compound that can serve as an LSD1 inhibitor.
  • the compound of the present application is suitable for making into medicines in various dosage forms It can be widely used to treat tumors such as papillary thyroid cancer, breast cancer, gastric cancer, bronchial cancer, lung cancer, acute myeloid leukemia, small cell lung cancer, prostate cancer or non-Hodgkin lymphoma.
  • the compounds and pharmaceutical compositions of the present application may also find application in the veterinary treatment of mammals such as pets, introduced breeds, and farm animals. Other examples of animals include horses, dogs, and cats.
  • the compounds of the present application include pharmaceutically acceptable derivatives thereof.
  • the compounds of the present application can be prepared by the methods described in the present application, unless there is further explanation, in which the substituents are defined as shown in formula (I).
  • the following reaction schemes and examples serve to further illustrate the content of this application.
  • LCMS models used for detection in the following examples are Agilent 1200Series, Agilent 1260Infinity 2 or Agilent 1260-6125B, and the nuclear magnetic model: Bruker AVANCE 3 400MHZ Ultra shield TM Digital NMR.
  • each of X 1 , X 2 , X 3 , X 4 , X 5 , , n 3 , n 4 , n 5 , n 6 , Rn1, Rn2, Rn3, Rn4, Rn5, m1, m2, m3, m4, m5 have the definitions as described in this application.
  • the halogenated heterocyclic compound Ia undergoes Mitsunobu reaction with R 2 -OH to obtain intermediate Ib, and the latter undergoes Suzuki coupling reaction with Ic to obtain intermediate Id.
  • Id reacts with R 1 -OH in the presence of NaH as a base to obtain compound I'.
  • Dissolve compound 4-6 (1.1g, 2.4mmol) in dichloromethane (20mL), add trifluoroacetic acid (3mL), react at room temperature for 5 hours, concentrate to remove the solvent, and add 12M amine in methanol to the crude residue.
  • Solution (20 mL) continue stirring at room temperature for 30 minutes, rotate to remove the solvent, and obtain a white solid, which is slurried with an appropriate amount of methylene chloride and filtered.
  • the obtained filter cake is redissolved with a large amount of ethyl acetate and washed with water several times to remove the suspended solid.
  • the organic phase was dried over anhydrous sodium sulfate and concentrated to obtain compound 4-7 as a white solid (700 mg, yield: 88%).
  • LCMS(M+H) + 335.0.
  • Dissolve compound 21-2 (60 mg, 0.4 mmol) in DMF (4 mL), add sodium hydrogen (11 mg, 0.4 mmol) in batches under an ice-water bath, stir the reaction at room temperature for 30 minutes after the addition, and add the compound in batches under an ice-water bath.
  • 21-3 (100 mg, 0.2 mmol), raise the temperature to 100°C and stir for 3 hours.
  • Dissolve compound 25-3 (160 mg, 0.576 mmol) in THF (3 mL), add 0.3 mL of 3M sodium hydroxide (46 mg, 1.15 mmol) aqueous solution in an ice water bath, and then add hydrogen peroxide (44 mg, 1.15 mmol). , react at room temperature for 3 hours, adjust the pH to weak acidity with 3M dilute hydrochloric acid, and remove the solvent from the reaction mixture through a freeze dryer to obtain crude white solid mixture 25-4 (90 mg, yield: 93%).
  • LCMS(M+H) + 169.0.
  • the purpose of this experiment is to detect the in vitro inhibitory activity of the compound of the present application on LSD1.
  • the purpose of this experiment is to detect the in vitro inhibitory activity of the compound of the present application on LSD1.
  • This experiment uses the AlphaScreen method to test the in vitro enzyme level inhibitory activity of the compound of the present application on LSD1.
  • the experimental steps are as follows:
  • Equation 1:Inh% (Max-Signal)/(Max-Min)*100
  • Y is the inhibition rate
  • X is the compound concentration
  • Table 1 shows the experimental data on the inhibitory activity of some compounds of the present application on LSD1.
  • Example B Pharmacokinetic evaluation of the compound of the present application after intravenous injection or oral administration in mice
  • the purpose of this experiment is to detect the pharmacokinetic properties of the compound of this application in mice.
  • the test compound was dissolved in 10% DMSO/10% Solutol HS15/80% physiological saline, vortexed and ultrasonicated to prepare a clear solution of corresponding concentration, and filtered with a microporous membrane for later use.
  • CD-1 mice weighing 21 to 27 grams were selected, and the test compound solution was administered intravenously at a dose of 5 mg/kg.
  • the test compound was dissolved in 10% DMSO/10% Solutol HS15/80% physiological saline, vortexed and ultrasonicated to prepare a clear solution of corresponding concentration, and filtered with a microporous membrane for later use.
  • CD-1 mice weighing 21 to 27 grams were selected, and the test compound solution was orally administered at a dose of 5 mg/kg.
  • Whole blood was collected at a certain time point, plasma was prepared, drug concentration was analyzed by LC-MS/MS method, and pharmacokinetic parameters were calculated using Phoenix WinNonlin software.
  • first and second are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Therefore, features defined as “first” and “second” may explicitly or implicitly include at least one of these features.
  • “plurality” means at least two, such as two, three, etc., unless otherwise expressly and specifically limited.
  • references to the terms “one embodiment,” “some embodiments,” “an example,” “specific examples,” or “some examples” or the like means that specific features are described in connection with the embodiment or example. , structures, materials or features are included in at least one embodiment or example of the present application. In this specification, the schematic expressions of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, those skilled in the art may combine and combine different embodiments or examples and features of different embodiments or examples described in this specification unless they are inconsistent with each other.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un composé ayant une structure représentée par la formule (I), ou un stéréoisomère, un tautomère, une forme deutérée, un N-oxyde, un solvate, un métabolite, un sel pharmaceutiquement acceptable ou un promédicament de celui-ci.
PCT/CN2023/083163 2022-04-28 2023-03-22 Dérivé de pyrrolo[2,3-d]pyrimidine ou de pyrazolo[3,4-d]pyrimidine et son utilisation WO2023207447A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210471007.6A CN117003754A (zh) 2022-04-28 2022-04-28 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途
CN202210471007.6 2022-04-28

Publications (1)

Publication Number Publication Date
WO2023207447A1 true WO2023207447A1 (fr) 2023-11-02

Family

ID=88517287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/083163 WO2023207447A1 (fr) 2022-04-28 2023-03-22 Dérivé de pyrrolo[2,3-d]pyrimidine ou de pyrazolo[3,4-d]pyrimidine et son utilisation

Country Status (2)

Country Link
CN (1) CN117003754A (fr)
WO (1) WO2023207447A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024110649A1 (fr) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 et d'inhibiteurs de ménine pour le traitement du cancer

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763597A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. Orally active adenosine kinase inhibitors
US5763596A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
WO2003090751A1 (fr) * 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de metalloproteinase a base de pyrimidine-2, 4, 6-trione
WO2003091258A1 (fr) * 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de la metalloproteinase n-substitues-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione
WO2011004132A1 (fr) * 2009-07-10 2011-01-13 Sanofi-Aventis Nouveaux derives de l'indole inhibiteurs d'hsp90, compositions les contenant et utilisation
CN102439003A (zh) * 2009-03-19 2012-05-02 赛诺菲 抑制hsp90的吲唑衍生物、含有所述衍生物的组合物及其用途
CN102471335A (zh) * 2009-07-10 2012-05-23 大鹏药品工业株式会社 氮杂二环式化合物或其盐
CN103402995A (zh) * 2011-01-07 2013-11-20 大鹏药品工业株式会社 新型吲哚、吲唑衍生物或其盐
CN104870422A (zh) * 2012-10-31 2015-08-26 富山化学工业株式会社 新颖的胺衍生物或其盐
WO2020238900A1 (fr) * 2019-05-27 2020-12-03 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Inhibiteur de protéine kinase dépendante de l'adn
CN113354648A (zh) * 2020-03-03 2021-09-07 轶诺(浙江)药业有限公司 新型hpk1抑制剂及其制备方法和应用
US11427578B1 (en) * 2017-07-18 2022-08-30 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyridine-derivatives

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763597A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. Orally active adenosine kinase inhibitors
US5763596A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
WO2003090751A1 (fr) * 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de metalloproteinase a base de pyrimidine-2, 4, 6-trione
WO2003091258A1 (fr) * 2002-04-26 2003-11-06 Pfizer Products Inc. Inhibiteurs de la metalloproteinase n-substitues-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione
CN102439003A (zh) * 2009-03-19 2012-05-02 赛诺菲 抑制hsp90的吲唑衍生物、含有所述衍生物的组合物及其用途
WO2011004132A1 (fr) * 2009-07-10 2011-01-13 Sanofi-Aventis Nouveaux derives de l'indole inhibiteurs d'hsp90, compositions les contenant et utilisation
CN102471335A (zh) * 2009-07-10 2012-05-23 大鹏药品工业株式会社 氮杂二环式化合物或其盐
CN103402995A (zh) * 2011-01-07 2013-11-20 大鹏药品工业株式会社 新型吲哚、吲唑衍生物或其盐
CN104870422A (zh) * 2012-10-31 2015-08-26 富山化学工业株式会社 新颖的胺衍生物或其盐
US11427578B1 (en) * 2017-07-18 2022-08-30 Bayer Pharma Aktiengesellschaft Substituted pyrrolopyridine-derivatives
WO2020238900A1 (fr) * 2019-05-27 2020-12-03 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Inhibiteur de protéine kinase dépendante de l'adn
CN113354648A (zh) * 2020-03-03 2021-09-07 轶诺(浙江)药业有限公司 新型hpk1抑制剂及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EL HAFI MOHAMED, NAAS MOHAMMED, LOUBIDI MOHAMMED, JOUHA JABRANE, RAMLI YOUSSEF, MAGUE JOEL T., ESSASSI EL MOKHTAR, GUILLAUMET GÉRA: "Palladium-catalyzed regioselective direct C H arylation of pyrazolo[3,4- d ]pyrimidines", COMPTES RENDUS CHIMIE, ELSEVIER, PARIS., FR, vol. 20, no. 9-10, 1 September 2017 (2017-09-01), FR , pages 927 - 933, XP093103873, ISSN: 1631-0748, DOI: 10.1016/j.crci.2017.06.004 *
OTTO, D. ET AL.: "Trypanocide Diamidine mit drei isolierten Ringsystemen", LIEBIGS ANN. CHEM., 31 December 1975 (1975-12-31), XP000931371, ISSN: 0075-4617 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024110649A1 (fr) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 et d'inhibiteurs de ménine pour le traitement du cancer

Also Published As

Publication number Publication date
CN117003754A (zh) 2023-11-07

Similar Documents

Publication Publication Date Title
CN109415360B (zh) 用于抑制shp2活性的化合物和组合物
CN109475531B (zh) Ptpn11的杂环抑制剂
CN104918934B (zh) 3‑取代的吡唑及其作为dlk抑制剂的用途
KR101837223B1 (ko) 피리디논/피라지논, 그의 제조 방법 및 사용 방법
CN107253963B (zh) 吡啶酮和氮杂吡啶酮化合物及使用方法
WO2019158019A1 (fr) Composé cyclique fusionné à une pyrimidine, son procédé de préparation et son application
CN111440189B (zh) 稠环嘧啶氨基衍生物、其制备方法、中间体、药物组合物及应用
WO2015127872A1 (fr) Dérivés de 1,5-diamine phénylène 2,4-disubstitués et leurs applications, compositions pharmaceutiques et compositions pharmaceutiquement acceptables préparées à partir de ces dérivés
TW201718536A (zh) 可作為ＴＮＦα調節劑之雜環化合物
WO2020200158A1 (fr) Dérivés d'amide n-hétéroaromatiques destinés au traitement du cancer
WO2016169421A1 (fr) Dérivé imidazo isoindole, méthode de préparation correspondante et utilisation médicale correspondante
TW201506018A (zh) 二雜芳基化合物及其用途
CN105939997A (zh) 作为dlk抑制剂的吡唑衍生物及其用途
CN109988106B (zh) 抑制ssao/vap-1的胺类化合物及其在医药上的应用
JP2023535932A (ja) 三環式のヘテロ環
AU2011258389A1 (en) Substituted-6-methylnicotinamides as mGluR5 positive allosteric modulators
JP2023509155A (ja) ビフェニル系誘導体阻害剤、その調製方法及び使用
WO2022048631A1 (fr) Composé ayant une activité antitumorale et son utilisation
WO2021041970A1 (fr) Composés d'imidazolopyrazine inhibiteurs de perk
TW201927787A (zh) 吡咯並三嗪化合物及抑制ｔａｍ激酶之方法
WO2023207447A1 (fr) Dérivé de pyrrolo[2,3-d]pyrimidine ou de pyrazolo[3,4-d]pyrimidine et son utilisation
WO2023179078A1 (fr) Dérivé d'imidazo[1,2-a]pyrazine ou de pyrazolo[1,5-a]pyrimidine et son utilisation
EP3233839B1 (fr) Dérivés d'imidazopyridazine liés à de l'hétérocyclyle en tant qu'inhibiteurs de pi3kbeta
WO2023109751A1 (fr) Dérivé de pyrimidine ou de pyridine et son utilisation médicinale
WO2023036252A1 (fr) Dérivé de pyrrolopyrimidine ou de pyrrolopyridine et son utilisation médicale

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23794882

Country of ref document: EP

Kind code of ref document: A1