WO2023199992A1 - Flow path opening/closing valve for chemical circuit, and chemical circuit comprising said flow path opening/closing valve - Google Patents

Flow path opening/closing valve for chemical circuit, and chemical circuit comprising said flow path opening/closing valve Download PDF

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Publication number
WO2023199992A1
WO2023199992A1 PCT/JP2023/015093 JP2023015093W WO2023199992A1 WO 2023199992 A1 WO2023199992 A1 WO 2023199992A1 JP 2023015093 W JP2023015093 W JP 2023015093W WO 2023199992 A1 WO2023199992 A1 WO 2023199992A1
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WIPO (PCT)
Prior art keywords
piston
flow path
valve
syringe
case
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Application number
PCT/JP2023/015093
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French (fr)
Japanese (ja)
Inventor
笠原　正孝
進 平野
かほり 安永
優作 荒井
顕識 仲田
Original Assignee
株式会社根本杏林堂
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Publication of WO2023199992A1 publication Critical patent/WO2023199992A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body

Definitions

  • the present invention relates to a flow path opening/closing valve used in a chemical liquid circuit including a plurality of tubes, etc., and a chemical liquid circuit equipped with the flow path opening/closing valve.
  • a drug injection device is often used to inject a drug into a subject. From the viewpoint of easy injection at a desired injection rate, many drug injection devices attach a syringe detachably and fill the syringe through a drug circuit that fluidly connects the syringe and the subject. The device is configured to inject a medicinal solution.
  • a syringe is used only once, but it is often used multiple times by refilling the syringe with drug solution from the bottle.
  • the injection circuit has a subject line leading from the syringe to the subject, and a bottle line branching from the subject line and leading to the bottle.
  • the bottle line is closed when a drug solution is injected, but when a drug solution is filled, the bottle line is opened after the subject line is closed downstream from the branch of the bottle line. At this time, it is important to prevent the subject's blood flowing backward through the subject line (reverse blood) from reaching the upstream side of the closed part of the subject line.
  • Patent Document 1 International Publication No. 2018/181270
  • the above-mentioned closing part is connected to a first moving member having a flow path and a flow path.
  • a second moving member having a path and located downstream of the subject line than the first moving member, and a housing that slidably accommodates the first moving member and the second moving member
  • a chemical liquid circuit is disclosed in which the flow path of the second moving member is opened after the flow path of the first moving member is opened.
  • Chemical liquid circuits are consumables that are replaced each time they are used once or multiple times, and they include not only tubes that serve as flow paths for chemical liquids, but also various parts such as on-off valves and connectors for controlling the flow of chemical liquids. is used. Further, in the chemical liquid circuit, a contrast medium is often used as the chemical liquid, and a high pressure of, for example, 2.07 ⁇ 10 6 to 8.27 ⁇ 10 6 Pa (300 to 1200 psi) acts on the chemical liquid circuit. Therefore, each component that makes up the chemical liquid circuit, especially the mechanical parts that involve movement, is required to operate stably even under high pressure.For example, in a flow path opening/closing valve, even if high pressure is applied, chemical liquid may leak. It is important that there is no Therefore, an object of the present invention is to provide a mechanical component such as a flow path opening/closing valve that is suitable for use in a chemical liquid circuit and can operate stably even under high pressure.
  • a flow path opening/closing valve used in a chemical liquid circuit a housing with an inlet and an outlet; a piston slidably inserted into the housing so as to be capable of assuming open and closed positions; a stopper structure having a convex portion that limits a movement range of the piston relative to the housing, and a recess that extends in a sliding direction of the piston and receives the convex portion; has The concave portion has a first end portion that the convex portion abuts when the piston is in the open position, and a second end portion that the convex portion abuts when the piston is in the closed position. the length is determined so as to have, and The convex portion is formed on one of the housing and the piston, and the concave portion is formed on the other.
  • a flow path opening/closing valve is provided.
  • upstream and downstream mean “upstream” and “downstream” with respect to the flow direction of the drug solution.
  • upstream and downstream with respect to the flow direction of the medicinal solution during injection of the medicinal solution are meant.
  • FIG. 1 is a schematic diagram of a medical image capture system according to an embodiment of the invention.
  • FIG. 2 is a schematic diagram of the chemical liquid circuit shown in FIG. 1.
  • FIG. FIG. 2 is an exploded perspective view of one form of a syringe that can be used in the liquid drug injection device shown in FIG. 1.
  • FIG. FIG. 3 is a perspective view of one form of the flow path opening/closing valve shown in FIG. 2.
  • FIG. 5 is a perspective view of the housing of the flow path on-off valve shown in FIG. 4.
  • FIG. 6 is a cross-sectional perspective view taken along line 5A-5A of the housing shown in FIG. 5.
  • FIG. FIG. 5 is a perspective view of a piston of the flow path opening/closing valve shown in FIG.
  • FIG. 7 is a cross-sectional perspective view taken along line 6A-6A of the piston shown in FIG. 6.
  • FIG. 7 is a cross-sectional perspective view taken along line 6B-6B of the piston shown in FIG. 6.
  • FIG. 5 is a sectional view taken along line 7A-7A of the flow path opening/closing valve shown in FIG. 4 at an open position and a closed position.
  • FIG. 5 is a sectional view taken along line 7B-7B of the flow path opening/closing valve shown in FIG. 4 at an open position and a closed position.
  • FIG. 7B is a cross-sectional view similar to FIG. 7B, showing an enlarged view of the stopper mechanism shown in FIG. 7B.
  • FIG. 2 is a perspective view of a first embodiment of a one-way valve that can be used in a chemical liquid circuit.
  • FIG. 8A is an exploded perspective view of the one-way valve shown in FIG. 8A.
  • FIG. 8C is a sectional view taken along line 8C-8C of the one-way valve shown in FIG. 8A.
  • 8A is a perspective view of the first case of the one-way valve shown in FIG. 8A.
  • FIG. 8A is a perspective view of a second case of the one-way valve shown in FIG. 8A.
  • FIG. FIG. 7 is a sectional view showing a closed state of a second one-way valve used in a chemical liquid circuit.
  • FIG. 7 is a cross-sectional view showing a second type of one-way valve that can be used in a chemical liquid circuit in an open state. It is a perspective view of the form 3 of a one-way valve which can be used for a chemical liquid circuit.
  • FIG. 10B is an exploded perspective view of the one-way valve shown in FIG. 10A.
  • FIG. 10A is a cross-sectional view of the one-way valve shown in FIG. 10A.
  • It is a perspective view of the form 4 of a one-way valve which can be used for a chemical liquid circuit.
  • FIG. 11B is an exploded perspective view of the one-way valve shown in FIG. 11A.
  • FIG. 11A is a cross-sectional view of the one-way valve shown in FIG. 11A.
  • FIG. 11A is a cross-sectional view of the one-way valve shown in FIG. 11A.
  • FIG. 2 is a perspective view of a suction tube unit that can be used in a chemical liquid circuit.
  • 13 is a perspective view of the suction valve of the suction tube unit shown in FIG. 12.
  • FIG. 12A is an exploded perspective view of the suction valve shown in FIG. 12A.
  • FIG. 12C is a cross-sectional perspective view taken along line 12C-12C of the suction valve shown in FIG. 12A.
  • FIG. 12B is a perspective view of the spike of the suction tube unit shown in FIG. 12A.
  • 12E is a cross-sectional perspective view taken along line 12E-12E of the spike shown in FIG. 12A.
  • FIG. 7 is a partially cross-sectional side view of a modified example of a syringe connector and a syringe.
  • 2 is a block diagram showing the configuration of an injection head of the medical image capturing system shown in FIG. 1.
  • FIG. 15 is a perspective view of the head main body of the injection head shown in FIG. 14.
  • FIG. 15 is a perspective view of the head main body of the injection head shown in FIG. 14.
  • angio imaging system that is preferably used for cardiac catheterization using coronary angiography will be described as an example, but the present invention is not limited to this. It is also applicable to PET (Positron Emission Tomography) systems, etc.
  • FIG. 1 there is shown a schematic diagram of a medical image capture system according to an embodiment of the present invention, which includes a drug solution injection device 10, a drug solution circuit 30, and a medical image capture device 50.
  • the chemical liquid injection device 10 includes an injection head 10a and a console 10b.
  • the chemical liquid circuit 30 fluidly connects the injection head 10a and the subject.
  • the liquid drug injection device 10 and the medical image capturing device 50 can be connected to each other so that data can be transmitted and received between them.
  • the connection between the two may be a wired connection or a wireless connection.
  • the medical image capturing apparatus 50 includes an imaging operation unit 52 that executes an imaging operation and an imaging control unit 51 that controls the operation of the imaging operation unit 52. Medical images including tomographic images and/or three-dimensional images of the examiner can be acquired.
  • the imaging operation unit 52 usually includes a bed for the subject, an electromagnetic wave irradiation unit that irradiates electromagnetic waves to a predetermined space above the bed, and the like.
  • the imaging control unit 51 controls the operation of the entire medical image capturing apparatus, such as determining imaging conditions and controlling the operation of the imaging operation unit 52 according to the determined imaging conditions.
  • the imaging control unit 51 can be configured to include a so-called microcomputer, and can have a CPU, ROM, RAM, and interfaces with other devices.
  • a computer program for controlling the medical image capturing apparatus 50 is installed in the ROM.
  • the CPU controls the operation of each part of the medical image capturing apparatus 50 by executing various functions in accordance with this computer program.
  • the medical image capturing apparatus 50 can further include a display device 54 such as a liquid crystal display that can display imaging conditions, acquired medical images, etc., and an input device 53 for inputting imaging conditions and the like.
  • a display device 54 such as a liquid crystal display that can display imaging conditions, acquired medical images, etc.
  • an input device 53 for inputting imaging conditions and the like.
  • the input device 53 at least one kind of known input devices such as various buttons, a keyboard, and a mouse can be used.
  • At least part of the data used to determine the imaging conditions is input from the input device 53 and sent to the imaging control unit 51.
  • Data displayed on the display device 54 is transmitted from the imaging control unit 51.
  • a touch panel in which a touch screen is disposed as an input device on a display that is a display device can also be used as the input device 53 and the display device 54.
  • a portion of the input device 53, the display device 54, and the imaging control unit 51 can be incorporated into one housing as a console for the medical image capturing apparatus.
  • the drug solution injection device 10 is a device used to inject a drug solution filled in a syringe into a blood vessel of a subject via a drug solution circuit 30.
  • the syringe is removably mounted on the injection head 10a, and at least one syringe drive mechanism for operating the plunger (or piston) of the syringe is built into the injection head 10a.
  • the injection head 10a is configured to be able to mount two syringes 20A and 20B so that two types of medical solutions, such as a contrast medium and physiological saline, can be injected separately or simultaneously.
  • 20B have two syringe drive mechanisms that independently operate the syringes.
  • at least one of the syringe drive mechanism for injecting one drug solution and the other syringe drive mechanism for injecting a drug solution may be plural.
  • the illustrated syringe is generally called a rodless syringe, and includes a cylinder 22 having a flange 22a and a nozzle portion 22b formed at its distal end and tip, respectively, and a plunger 23 inserted into the cylinder 22 so as to be movable forward and backward. are doing.
  • a flange-shaped convex portion (not shown) that engages with the syringe drive mechanism of the injection head 10a is integrally formed at the end of the plunger 23.
  • the syringe may be a prefilled syringe provided by a manufacturer filled with a medical solution, or it may be an on-site filling type syringe filled with a medical solution at a medical site.
  • the syringe is inserted into the protective cover 21 and attached to the injection head 10a.
  • the protective cover 21 has a cylindrical shape with a size that substantially leaves no gap between the outer circumferential surface of the cylinder 22 and the inner circumferential surface of the protective cover 21 in order to suppress expansion due to an increase in the internal pressure of the cylinder 22 during injection of the chemical solution. It is a part composed of.
  • the protective cover 21 is formed with a wall thickness that has sufficient mechanical strength to withstand the internal pressure that acts on the cylinder 22 during injection of the chemical solution.
  • An opening is formed at the tip of the protective cover 21, and the cylinder 22 is inserted into the protective cover 21 with the nozzle portion 22b protruding from this opening.
  • a cover flange 21a is formed at the end of the protective cover 21 and has a ring-shaped recess for receiving the flange 22a of the cylinder 22.
  • the syringe is used by being inserted into the protective cover 21, but the protective cover 21 is not essential in the present invention, and the syringe may be directly attached to the injection head 10a.
  • the console 10b has an injection control unit 11, an input device 12 and a display device 13.
  • the injection control unit 11 uses at least part of the data input from the input device 12 to determine injection conditions such as the injection amount and injection speed of the drug solution, and performs injection so that the drug solution is injected according to the determined injection conditions. It controls the operation of the entire chemical liquid injector, such as controlling the operation of the head 10a and controlling the display of the display device 13.
  • the injection control unit 11 can be configured to include a so-called microcomputer, and can have a CPU, ROM, RAM, and interfaces with other devices.
  • a computer program for controlling the liquid drug injection device 10 is installed in the ROM.
  • the CPU can control the operation of each part of the liquid drug injection device 10 by executing various functions in accordance with this computer program.
  • the input device 12 is a device used to input data and the like used for determining the injection conditions of the drug solution in the injection control unit 11.
  • the input device 12 for example, at least one kind of known input devices such as various buttons, a keyboard, and a mouse can be used.
  • Data input from the input device 12 is sent to the injection control unit 11, and data displayed on the display device 13 is sent from the injection control unit 11.
  • the display device 13 is controlled by the injection control unit 11, and displays data necessary for determining injection conditions of the drug solution, injection protocols, injection operations, various guidances, and various warnings. conduct.
  • the injection protocol indicates what kind of drug solution is to be injected, in what amount, and at what speed.
  • the injection rate may be constant or may vary over time.
  • the injection protocol also includes information such as in what order these medical solutions should be injected. Any known injection protocol can be used as the injection protocol.
  • a known procedure can be used for setting the injection protocol, and the set injection protocol can be changed arbitrarily by the user.
  • the injection protocol may also include maximum allowable injection pressures (pressure limits). If a pressure limit is set, the injection pressure is monitored during the injection operation, and the operation of the injection head 10a is controlled so that the injection pressure does not exceed the set pressure limit.
  • the display device 13 may be a known display device such as a liquid crystal display device. Further, a touch panel in which a touch screen is disposed as an input device on a display that is a display device can also be used as the input device 12 and the display device 13. Some of the input devices 12 may be provided separately from the console.
  • the chemical liquid circuit 30 constitutes a liquid flow path that communicates the syringe and the subject, and can include at least one tube, at least one connector, and at least one valve.
  • FIG. 2 shows one form of a chemical liquid circuit 30 that can be suitably used in the chemical liquid injection device 10 shown in FIG. 1.
  • the chemical liquid circuit 30 shown in FIG. 2 is connected to the syringes 20A and 20B, and is used when injecting the first medical liquid and the second medical liquid contained in the syringes 20A and 20B, respectively, into the subject.
  • the chemical liquid circuit 30 can also be connected to a first container 40A and a second container 40B which respectively contain a first chemical liquid and a second medical liquid, and connect the first container 40A and the second container 40B to each syringe 20A, 20B. It is also possible to suck the first medical liquid and the second medical liquid, respectively.
  • the first medical liquid and the second medical liquid are medical medical liquids, and a case will be described below in which the first medical liquid is a contrast agent and the second medical liquid is physiological saline.
  • the chemical liquid circuit 30 includes a first main line 301a connected to a syringe 20A containing a contrast medium, a second main line 302a connected to a syringe 20B containing physiological saline, and a first main line 302a connected to a syringe 20B containing a contrast medium.
  • a transducer line 304 is provided.
  • the term “line” refers to a channel through which a liquid flows, and includes various members through which the liquid flows (for example, various tubes, T-shaped pipes, various fluid connectors, various valves, mixing devices, etc.). Furthermore, in FIG. 2, each line is shown for convenience of illustration, and the relative length of each line does not represent the relative length of the actual line.
  • the term “tube” used in the following explanation may be composed of a single tube member, or may be composed of a plurality of tube members connected together.
  • the tube assembly may be made up of a tube assembly.
  • the first main line 301a includes, in order from the upstream side, a syringe connector 310a, a T-tube 311a, a first tube 312a, a rotating high-pressure adapter 313a, a female Luer lock connector 314a, and a second tube 315a.
  • the syringe connector 310a is rotatably connected to the T-tube 311a via a rotary joint, and the syringe 20A is detachably connected thereto.
  • the rotating high-pressure adapter 313a and the female Luer lock connector 314a are detachably connected. Accordingly, the first main line 301a can be separated between the first tube 312a and the second tube 315a.
  • the first subline 301b connects the first container 40A and the first main line 301a.
  • the first subline 301b includes, in order from the first container 40A side, a spike 310b, a third tube 311b, a drip chamber 312b, a fourth tube 313b, and a one-way valve 314b.
  • Spike 310b is connected to first container 40A.
  • the one-way valve 314b is installed in a direction that allows liquid to flow only in the direction from the first container 40A toward the first main line 301a, and is connected to the T-shaped pipe 311a of the first main line 301a.
  • the first container 40A is, for example, a bottle-shaped container, and the contrast agent flowing out from the first container 40A is dripped into the drip chamber 312b and then supplied to the first main line 301a.
  • the chemical solution is prevented from flowing into the first sub-line 301b from the first main line 301a.
  • the second main line 302a includes, in order from the upstream side, a syringe connector 320a, a T-tube 321a, a first tube 322a, a rotating high-pressure adapter 323a, a female Luer lock connector 324a, and a second tube 325a.
  • the syringe connector 320a is rotatably connected to the T-tube 321a via a rotary joint, and the syringe 20B is detachably connected thereto.
  • the rotating high-pressure adapter 323a and the female Luer lock connector 324a are detachably connected. Accordingly, the second main line 302a can be separated between the first tube 322a and the second tube 325a.
  • the second subline 302b connects the second container 40B and the second main line 302a.
  • the second subline 302b includes, in order from the second container 40B side, a spike 320b, a third tube 321b, a drip chamber 322b, a fourth tube 323b, and a one-way valve 324b.
  • Spike 320b is connected to second container 40B.
  • the one-way valve 324b is installed in a direction that allows liquid to flow only in the direction from the second container 40B toward the second main line 302a, and is connected to the T-shaped pipe 321a of the second main line 302a.
  • the second container 40B is, for example, a bag-shaped container, and the physiological saline flowing out from the second container 40B is supplied to the second main line 302a after dripping into the drip chamber 322b.
  • the chemical solution is prevented from flowing into the second subline 302b from the second main line 302a.
  • the subject line 303 includes, in order from the upstream side, a mixing device 330, a fifth tube 331, a flow path on-off valve 332, a one-way valve 333 connected to the flow path on-off valve 332 via a tube, a T-shaped pipe 334, and a fifth tube. 6 tubes 335 and connectors 336.
  • the mixing device 330 has two inlets and one outlet, and is configured to mix liquids flowing in from each inlet and flowing out from the outlet. Each inlet of the mixing device 330 is connected to the second tube 315a of the first main line 301a and the second tube 325a of the second main line 302a, respectively.
  • the outlet of the mixing device 330 is connected to the fifth tube 331 .
  • the mixing device 330 for example, "SPIRAL FLOW" (registered trademark) manufactured by Nemoto Kyorindo Co., Ltd. can be used.
  • a T-shaped connector can be used instead of the mixing device 330.
  • the flow path opening/closing valve 332 is a unit configured to be able to control opening and closing of the flow path.
  • the channel opening/closing valve 332 will be described in detail later.
  • the one-way valve 333 is installed in an orientation that allows liquid to flow only in the direction from upstream to downstream.
  • the connector 336 is arranged at the downstream end of the subject line 303, and the subject line 303 is connected to a catheter or the like to be punctured or inserted into the subject via the connector 336.
  • the transducer line 304 is a line connected to the T-tube 334 of the subject line 303 so as to branch from the subject line 303, and is a line connected to the T-shaped tube 334 of the subject line 303 in order from the T-shaped tube 334 side.
  • the tube assembly 340 includes a plurality of tubes, and a connector 343. At least a portion of the tube assembly 340 is flexible enough to be crushed by being pinched from the outside.
  • the transducer 70 is connected to the connector 343 in order to detect the subject's blood pressure and monitor the pulse.
  • a display (not shown) that displays the pulse waveform of the subject is connected to the transducer 70.
  • the chemical liquid circuit 30 configured as described above can be divided into a downstream single-use section 300A and an upstream multi-use section 300B.
  • the single-use portion 300A is a so-called disposable portion that can be used only once.
  • the multiple-use portion 300B is a portion that can be used repeatedly multiple times.
  • the single-use portion 300A includes a downstream portion separated by the female Luer lock connector 314a of the first main line 301a, and a downstream portion separated by the female Luer lock connector 324a of the second main line 302a. 3, a subject line 303 and a transducer line 304.
  • the multiple use section 300B is a portion of the chemical liquid circuit 30 other than the single use section 300A, that is, the upstream portion of the first main line 301a separated by the rotating high pressure adapter 313a, the first subline 301b, and the second main line. 302a and a second subline 302b separated by a rotating high pressure adapter 323a.
  • the chemical liquid circuit 30 can further include an auxiliary circuit 350.
  • the auxiliary circuit 350 includes a female Luer lock connector 351 with a one-way valve, a tenth tube 352, and a male Luer lock connector 353 connected to the female Luer lock connector 351 via the tenth tube 352.
  • the one-way valve of the female Luer lock connector 351 allows liquid to flow only in the direction from the female Luer lock connector 351 to the male Luer lock connector 353.
  • the multi-use section 300B is connected to the syringes 20A, 20B and the drug solution containers 40A, 40B, air is removed.
  • one female Luer lock connector 351 is connected to each of the rotary high pressure adapter 313a of the first main line 301a and the rotary high pressure adapter 323a of the second main line 302a until air bleeding is completed.
  • the attached circuit 350 is removed from the first main line 301a and the second main line 302a, and the female Luer lock connectors 314a, 324a of the single-use portion 300A are connected to the rotating high voltage connectors 313a, 323a, respectively. Connected.
  • (B-a) Channel opening/closing valve As shown in FIG. 4, the channel opening/closing valve 332 is slidably inserted into the housing 501 in the direction of arrow S so that it can take an open position and a closed position. and a piston 502.
  • the flow path opening/closing valve 332 shown in FIG. 4 will be described below with reference to FIGS. 5, 5A, 6, 6A, and 6B.
  • the housing 501 can be molded, for example, by injection molding of resin, and has a cylinder portion 501c into which the piston 502 is slidably inserted.
  • the cylinder portion 501c is constituted by a through hole formed along the axial direction of the housing 501.
  • the housing 501 is provided with conduit portions 501a and 501b that are adjacent to the cylinder portion 501c and extend from the outer wall of the housing 501 in a direction perpendicular to the axial direction of the cylinder portion 501c.
  • One conduit section 501a is connected to the fifth tube 331 (see FIG. 2) of the subject line 303.
  • the other conduit section 501b is connected to the one-way valve 333 (see FIG. 2) of the subject line 303 via a tube. Therefore, in the illustrated embodiment, the conduit portion 501a serves as the inflow path, and the conduit portion 501b serves as the discharge path.
  • the housing 501 is formed with a communication channel 501e that communicates between one conduit section 501a and the cylinder section 501c, and a communication channel 501g that communicates between the other conduit section 501b and the cylinder section 501c.
  • These conduit portions 501a, 501b and communication channels 501e, 501g are arranged in alignment on a straight line.
  • the piston 502 is, for example, a columnar member molded by injection molding of resin, and has a flange-shaped head 502a that extends radially outward at one end thereof.
  • a flow path 502b is formed in a longitudinally intermediate portion of the piston 502 so as to cross the piston 502 in a direction perpendicular to the longitudinal direction of the piston 502.
  • Sealing rings 506 such as O-rings are attached to the outer peripheral surface of the piston 502 on both sides of the flow path 502b in the longitudinal direction of the piston 502, respectively.
  • the flow path opening/closing valve 332 further includes a stopper structure 503 that limits the movement range of the piston 502 with respect to the housing 501.
  • the stopper structure 503 has a protrusion 503a formed in the housing 501 and a recess 503b formed in the piston 502, as shown in FIG. 7C.
  • the recess 503b extends in the sliding direction of the piston 502 and receives the protrusion 503a.
  • the recessed portion 503b also has a first end 503c, which the convex portion 503a abuts when the piston 502 is in the open position, and a second end 503d, which the convex portion 503a abuts when the piston 502 is in the closed position.
  • the length of the piston 502 in the sliding direction is determined so as to have the following.
  • the protrusion 503a can be formed as a part of the housing 501, and the recess 503b can be formed as a part of the piston 502.
  • the stopper structure 503 can be configured only with the housing 501 and the piston 502 without using other parts, and the flow path opening/closing valve 332 can be configured with a smaller number of parts.
  • two convex portions 503a are formed on the outer peripheral surface of the housing 501 at equal angular intervals in the circumferential direction of the housing 501.
  • two recesses 503b are also formed in the piston 502 at equal angular intervals in the circumferential direction of the piston 502.
  • the number of protrusions 503a may be one, or three or more.
  • the number of concave portions 503b is also the same as the number of convex portions 503a.
  • the concave portion 503b is formed at one end of the piston 502 (in the illustrated form, the concave portion 503b is formed on the side opposite to the head 502a of the piston 502, as shown in the figure). Although it is formed at the end, it may be formed at the end on the head 502a side.) It is preferable to form it in a hook shape so as to extend beyond the peripheral wall of the housing 501 and wrap around the outer peripheral surface of the housing 501. .
  • the convex portion 503a it is possible to configure the convex portion 503a to be received in the concave portion 503b.
  • the housing 501 and the piston 502 can be connected by a snap-fit type connection without using any other parts other than the housing 501 and the piston 502.
  • a notch 503e is formed in the peripheral wall of the housing 501, and the recess 503b wraps around the outer peripheral surface of the housing 501 through the notch 503e, thereby making the flow path opening/closing valve 332 compact. can do.
  • the protrusion 501a is formed on the housing 501, and the recess 503b is formed on the piston 502, but the opposite may be used. That is, the housing 501 may have a recess and the piston 502 may have a protrusion.
  • a concave portion can be formed on the inner circumferential surface of the housing 501 and a convex portion can be formed on the outer circumferential surface of the piston 502.
  • FIG. 7A is a sectional view taken along the line 7A-7A of the flow path on-off valve 332 shown in FIG. 4, and FIG. This will be explained below with reference to 7B.
  • the flow path 502b of the piston 502 is located on the same straight line as the communication flow paths 501e and 501g of the housing 501, and the conduit portion 501a , 501b are in communication via a flow path 502b.
  • the first end 503c of the recess 503b of the piston 502 comes into contact with the protrusion 503a of the housing 501, and the piston 502 is moved in the pushing direction so that the piston 502 is not pushed further into the housing 501. The amount of movement is limited.
  • the recess 503b of the piston 502 also moves along the moving direction of the piston 502, and in the closed position, the convex part 503a is connected to the second end 503d of the recess 503b. come into contact with As a result, the amount of movement of the piston 502 in the withdrawal direction is limited so that the piston 502 is not pulled out any further from the housing 501.
  • the flow path opening/closing valve 332 can be operated by at least the housing 501, the piston 502, and the two It can be constructed of four parts: a sealing ring 506; Furthermore, since the stopper structure 503 is a structure that utilizes the engagement between the convex portion 503a and the concave portion 503b, the piston 502 is inserted into the housing 501, and the convex portion 503a and the concave portion 503b are further engaged in a snap-fit manner. By doing so, the flow path opening/closing valve 332 can be assembled without using adhesive. Therefore, the flow path opening/closing valve 332 of this embodiment can be configured with a minimum number of parts, and/or the number of assembly steps can be reduced, allowing for significant cost reduction.
  • the inner circumferential surface of the housing 501 and the outer circumferential surface of the piston 502 must be in contact at least in the closed position.
  • packing can be added to the outer peripheral surface of the piston 502.
  • the piston 502 and the housing 501 may be made of materials having different moduli of elasticity. In this case, packing is not necessary.
  • the housing 501 and the piston 502 are made of materials with different moduli of elasticity, for example, the housing can be made of polycarbonate (PC) and the piston can be made of high-density polyethylene (HDPE).
  • the pushing and pulling operations of the piston into and out of the housing 501 can be performed using the head 502a.
  • an engagement member that engages with the head 502a and is operated to reciprocate in the moving direction of the piston 502 is engaged with the head 502a, and the piston 501 is moved to the open position. and the closed position.
  • the movement of the piston 502 between the open and closed positions is such that the engagement member can more easily engage the head 502a and move the piston 502 between the open and closed positions.
  • one end of the piston 502 in the moving direction protrudes from the housing 501 in the moving range, and the head 502a is formed in the protruding portion.
  • both ends of the piston 502 in the moving direction protrude from the housing 501, or only one end of the piston 502 protrudes in the open position, It is also possible that only the other end of the piston 502 protrudes in the closed position.
  • the piston 502 can be moved between the open position and the closed position by pushing the piston 502 from both sides of the piston 502, so that the engaging member such as the head 502a can be engaged. No structure is required.
  • a rod-shaped pushing member can be used to push the piston 502.
  • the length of the piston 502 can be set to such a length that the piston 502 does not protrude from the housing 501 in both the open position and the closed position.
  • the flow path opening/closing valve 332 of the present embodiment includes a housing 501, a piston 502 slidably inserted into the housing 501, and a stopper structure 503 that limits the sliding amount of the piston 502.
  • the flow path opening/closing valve 332 is not limited to the configuration described above, and may have other configurations.
  • the opening/closing unit described in International Publication No. 2018/181270 can be used, or the crushing mechanism described below can also be used.
  • FIG. 8A a perspective view of a one-way valve 610 according to Form 1 is shown.
  • 8B shows an exploded perspective view of the one-way valve 610 shown in FIG. 8A, and
  • FIG. 8C shows a cross-sectional view of the one-way valve 610 taken along line 8C-8C in FIG. 8A.
  • the one-way valve 610 has a first case 611, a second case 612, and a valve body 613, and is configured to allow the flow of the chemical liquid only in the direction of arrow 8A.
  • the valve body 613 is a spherical member, and is movably arranged in a valve chamber 610a formed by fittingly joining the first case 611 and the second case 612.
  • FIGS. 8B, 8C, and FIG. 8D which is a perspective view taken from a different angle from FIG. have
  • the receiving recess 611a has a concave spherical surface as a whole and receives the spherical valve body 613.
  • the downstream flow path 611b communicates with the receiving recess 611a and opens at the end of the first case 611 opposite to the joint with the second case 612.
  • the valve body position regulating protrusion 611c is brought into contact with the valve body 613 that has moved downstream in the flow direction of the chemical solution in the one-way valve 610 (arrow 8A direction), so that the valve body 613 does not block the downstream flow path 611b.
  • the position of the valve body 613 is regulated as follows.
  • a groove 611d and/or a protrusion 611e may be formed on the surface of the receiving recess 611a of the first case 611.
  • the groove 611d is preferably formed along the flow direction of the chemical solution within the one-way valve 610 over the entire receiving recess 611a.
  • the convex portion 611e protrudes from the surface of the receiving recess 611a, it may be formed over the entire receiving recess 611a in the flow direction of the chemical solution in the one-way valve 610, or may be formed only in a part of the receiving recess 611a. may be formed.
  • the number of grooves 611d and the number of protrusions 611e may be one or two or more.
  • the number of grooves 611d and the number of protrusions 611e may be the same or different.
  • it is preferable that the plurality of grooves 611d are arranged at equal angular intervals in the circumferential direction of the one-way valve 610. This prevents uneven movement of the chemical liquid within the valve chamber 610a and prevents the valve from moving unbalanced.
  • the valve body 613 can be moved smoothly within the chamber 610a.
  • the case where a plurality of convex portions 611e are formed is similar to the case where a plurality of grooves 611d are formed.
  • the second case 612 has a valve seat 612a and an upstream flow path 612b, as shown in FIG. 8C and FIG. 8E, which is a perspective view taken along line 8C-8C in FIG. 8A.
  • the valve seat 612a has a concave spherical surface.
  • the upstream flow path 612b communicates with the valve seat 612a and opens at the end of the second case 612 opposite to the joint with the first case 611.
  • the valve body 613 moves inside the valve chamber 610a.
  • the fluid moves from the second case 612 side to the first case 611 side, thereby allowing fluid to flow inside the one-way valve 610. That is, one-way valve 610 opens.
  • the valve body 613 moves to the first case inside the valve chamber 610a.
  • the valve chamber 610a is moved from the 611 side to the second case 612 side, thereby closing the valve chamber 610a. That is, one-way valve 610 is closed.
  • the receiving recess 611a of the first case 611 has a concave spherical surface as a whole
  • the valve seat 612a of the second case 612 has a concave spherical surface.
  • the valve body 613 is a spherical member. Therefore, when the one-way valve 610 is open and fluid flows inside the valve chamber 610a formed by the receiving recess 611a and the valve seat 612a, turbulence is less likely to occur inside the valve chamber 610a, and the generation of air bubbles is suppressed. It has a structure that can be used.
  • the valve body 613 is made to move smoothly according to the change in fluid pressure between the upstream side and the downstream side.
  • the valve body 613 is preferably made of a material having a specific gravity smaller than the specific gravity of the fluid flowing through the one-way valve 610.
  • the valve body 613 can be made of polypropylene (PP). Thereby, backflow of fluid can be prevented.
  • Luer lock type connection structure is formed at the upstream end of the second case 612.
  • a luer lock type connector is also attached to the tube connected to the second case 612, so that the user can attach and detach the tube to the second case 612.
  • the method of joining the first case 611 and the second case 612 is not particularly limited, and examples thereof include bonding using an adhesive and welding such as thermal welding and ultrasonic welding.
  • an adhesive and welding such as thermal welding and ultrasonic welding.
  • one of the first case 611 and the second case 612 may serve as an injection port and a reservoir for the adhesive to the joint between the two.
  • a recess can be formed.
  • the joint between the first case 611 and the second case 612 is such that the outer circumferential surface of the first case 611 and the inner circumferential surface of the second case 612 are joined at their opposing end sides. configured to be used. Therefore, in the first embodiment, a recess 612d is formed in the second case 612, as shown in FIG. 8E.
  • the first case 611 When joining the first case 611 and the second case 612, first, the first case 611 is fitted into the second case 612 with the valve body 613 disposed between the first case 611 and the second case 612. . After that, adhesive is poured into the recess 612d of the second case 612. Then, the poured adhesive enters the joint surface between the first case 611 and the second case 612 due to capillary action. Furthermore, when the first case 611 is rotated in the circumferential direction of the one-way valve 610, the infiltrated adhesive spreads in the circumferential direction, and finally the adhesive spreads over the entire circumference of the joint surface between the first case 611 and the second case 612. is applied to. By drying the adhesive in this state, the first case 611 and the second case 612 are joined. Thereby, the first case 611 and the second case 612 can be easily and reliably joined.
  • a wider joint area is secured between the first case 611 and the second case 612 by fitting them together, and the valve body 613 is made of a spherical member.
  • a Luer lock type connection structure is formed at the upstream end of the second case 612 in order to allow the tube to be detachably attached to the second case 612. This is not essential, and the second case 612 and the tube may be bonded together. .
  • FIGS. 9A and 9B show cross-sectional views along the fluid flow direction of the second one-way valve.
  • 9A and 9B show the one-way valve in a closed and open state, respectively.
  • the basic configuration of the second embodiment is the same as the first embodiment, and includes a first case 611, a second case 612, and a valve body 613.
  • the size and material of the valve body 613 are different from those in the first embodiment.
  • a description of the configuration that may be the same as that of the first embodiment will be omitted, and the valve body 613 will be mainly described.
  • the valve body 613 has a main body 613a that is a spherical part and a protrusion 613b that is a part that projects from the main body 613a.
  • the protrusion 613b is located in a communication hole that communicates the valve chamber and the upstream flow path 612b, and has a size and shape that allows fluid to flow between the valve chamber and the upstream flow path 612b. Ru.
  • Such a protrusion 613b can be used to hold the valve body 613 in a fixed position when the first case 611 and the second case 612 are joined in assembling the one-way valve 610.
  • the valve body 613 may be arranged with respect to the second case 612 in such a direction that the protruding portion 613b can be positioned within the second communication hole when the valve body 613 is brought into contact with the valve seat 612a.
  • an elongated rod-shaped valve body fixing jig (not shown) is inserted into the upstream flow path 612b from the side opposite to the valve seat 612a of the second case 612.
  • the tip of the valve body fixing jig has a structure that can fix the protrusion 613b, and this structure is used to fix the valve body 613 to the inserted valve body fixing jig.
  • the valve body 613 is held in a fixed position with respect to the second case 612, so by joining the second case 612 and the first case 611 in this state, the valve body 610 can be assembled more easily. .
  • the valve body fixing jig is removed from the valve body 613.
  • the main body 613a which is the spherical portion of the valve body 613, has a larger diameter compared to the first embodiment, and the valve body occupancy rate, which is the ratio of the volume of the main body 613a to the volume of the valve chamber, is higher than the first embodiment.
  • the valve body occupancy rate can be expressed as Vb/Vc ⁇ 100 (%), where the volume of the valve chamber is Vc and the volume of the main body 613b of the valve body 613 is Vb.
  • the valve body occupancy rate is preferably 80% or more, more preferably 85% or more, and even more preferably 90% or more.
  • the valve body occupancy rate is preferably 95% or less.
  • the valve body 613 When the valve body occupancy rate is maximized within a practical range, the valve body 613 is sized so that it contacts the valve body position regulating protrusion 611c on the downstream side and contacts the valve seat 612a on the upstream side. be able to. In this case, since it is difficult for the valve body 613 to move within the valve chamber, the valve body 613 is formed of an elastic member such as rubber, and as the pressure acting on the valve body 613 increases on the upstream side of the valve body 613.
  • the one-way valve 610 is configured to open by elastically deforming the valve body 613. Specifically, the elastic deformation of the valve body 613 is compression, and as shown in FIG.
  • valve body 613 is compressed toward the downstream side and moves away from the valve seat 612a, thereby opening the valve 613.
  • the pressure acting on the upstream side of the valve body 613 returns to its original state, the shape of the valve body 613 is restored and the valve body 613 comes into contact with the valve seat 612a. This closes the one-way valve.
  • the material of the valve body 613 silicone rubber can be used.
  • the hardness of the valve body 613 is preferably 70 degrees or less, more preferably 50 degrees or less.
  • the valve body 613 will be compressed on the inner surface of the valve chamber over the entire circumferential direction of the one-way valve 610.
  • the opening/closing operation may fail due to contact with the valve chamber and blocking the valve chamber.
  • the hardness of the valve body 613 is preferably 30 degrees or more, more preferably 40 degrees or more.
  • the protruding portion 613b of the valve body 613 is not essential, and like the first form, it may be only a spherical portion. Conversely, in the first embodiment, the valve body 613 may have the protrusion 613b, as in the second embodiment.
  • FIG. 10A shows a perspective view of the third one-way valve
  • FIG. 10B shows an exploded perspective view thereof
  • FIG. 10C shows a cross-sectional view of the one-way valve of Form 3 along the fluid flow direction.
  • the basic configuration of form 3 is the same as form 2, and includes a first case 611, a second case 612, and a valve body 613.
  • the structure of the first case 611 is different from that in the second embodiment.
  • a description of the configuration that may be the same as that of the second embodiment will be omitted, and the first case 611 will be mainly described.
  • the first case 611 also has a structure that functions as a Luer lock type connector.
  • a luer lock type connector connected to this connector is also attached to the tube connected to the first case 611, so that the user can attach and detach the tube to the first case 611.
  • the second case 612 is also configured to allow the tube to be attached and removed, so according to the third embodiment, the user can freely remove the one-way valve 610 from the tube.
  • the first case 611 having such a structure functioning as a connector can also be applied to Form 1.
  • FIG. 11A shows a perspective view of form 4 of the one-way valve
  • FIG. 11B shows an exploded perspective view thereof
  • FIG. 11C shows a cross-sectional view of the one-way valve of Form 4 along the fluid flow direction.
  • the one-way valve 620 of the fourth embodiment also has a first case 621, a second case 622, and a valve body 623, as in the first to third embodiments, and allows the flow of the chemical liquid only in the direction of the arrow 11A.
  • the shape and structure are different from the configuration 3, and the configuration 4 further includes a gasket 624 and a biasing spring 625.
  • the first case 621 and the second case 622 each have a downstream flow path 621b and an upstream flow path 622b, and are joined to each other to form a valve chamber.
  • the method of joining the first case 621 and the second case 622 and the structure related to the joining may be the same as in the first embodiment.
  • Valve body 623, gasket 624, and biasing spring 625 are arranged within the valve chamber.
  • the valve body 623 has a valve body 623a, a leg portion 623b, a plurality of first convex portions 623c, and a plurality of second convex portions 623d, and is located within the valve chamber so as to be movable in the axial direction of the one-way valve 620.
  • the valve body 623a is a portion of the valve body 623 having a tapered downstream end.
  • the leg portion 623a is a portion of the one-way valve 620 that extends in the axial direction of the one-way valve 620 from the downstream end surface of the valve body 623a.
  • the first convex portion 623c is formed on the side surface of the valve body 623a, and prevents movement of the valve body 623a in the radial direction of the one-way valve 620.
  • the second convex portion 623d is formed on the upstream end surface of the valve body 623a to hold the gasket 624.
  • the gasket 624 is a hemispherical member and is arranged with the spherical surface facing upstream so that the spherical surface can close the valve chamber side opening of the upstream flow path 622b.
  • a recess is formed in the downstream end surface of the gasket 624, and the second protrusion 623d of the valve body 623 fits into the recess, thereby holding the gasket 624 on the valve body 623a.
  • the hemispherical top of the gasket 624 may have a protrusion similar to the protrusion 613b (see FIG. 9A) of the valve body 613 described in the second embodiment.
  • biasing spring 625 Any means can be used as the biasing spring 625 as long as it can bias the valve body 623 toward the upstream side of the one-way valve 620, but in the fourth embodiment, a coil spring is used, and the leg portion 623b is provided inside the coil spring. To position.
  • the spring coefficient of the biasing spring 625 is set according to a predetermined pressure at which the one-way valve 620 is to be opened and closed. By appropriately setting the spring coefficient of the biasing spring 625, it can be used as a one-way valve 620 that opens when a drug solution is drawn from a drug solution container into a syringe, or as a one-way valve that opens when a drug solution is injected from a syringe.
  • the downstream flow path 621b of the first case 621 has a first portion 621U, a second portion 621M, and a third portion 621L whose diameter gradually decreases from the upstream side to the downstream side. Formed with.
  • the first portion 621U has a diameter that allows the biasing spring 625 to be inserted but not the valve body 623a.
  • the second portion 621M has a diameter such that the leg 623b is insertable but the biasing spring 625 is not.
  • the third portion 621L has a diameter such that the leg portion 623b cannot be inserted.
  • the step between the first portion 621U and the second portion 621M functions as a stopper for the biasing spring 625
  • the step between the second portion 621M and the third portion 621L acts as a stopper of the leg portion 623b. Functions as a stopper.
  • the valve body 623a is urged upstream by the urging spring 625, and the valve chamber of the upstream flow path 622b is The side openings are closed by gaskets 624. That is, one-way valve 620 is closed.
  • the pressure acting on the upstream side of the valve 620 becomes greater than a predetermined pressure, or when the valve chamber becomes negative pressure, the valve body 623 moves downstream against the urging force of the urging spring 625. As a result, the gasket 624 moves away from the valve chamber side opening of the upstream flow path 622b, and the one-way valve 620 opens.
  • the chemical liquid circuit 30 may further include an additional unit.
  • Additional units include suction tube units used to aspirate medical fluids from medical fluid containers (40A, 40B) to syringes (20A, 20B).
  • suction tube unit used to aspirate medical fluids from medical fluid containers (40A, 40B) to syringes (20A, 20B).
  • FIG. 12 is a perspective view thereof
  • FIGS. 12A to 12E which are perspective views of each component constituting the suction tube unit.
  • the suction tube unit 400 includes a tube body 410, a suction valve 420 connected to one end of the tube body 410, an open/close dust cap 430 with a lid detachably attached to the open end of the suction valve 420, and a tube body. It has a spike 440 connected to the other end of 410 and a spike cap 450.
  • the suction valve 420 includes a first case 421, a second case 422, a valve body 423, and a coil spring 424.
  • the first case 421 and the second case 422 each have a flow path, and by joining the first case 421 and the second case 422, there is a flow path between the first case 421 and the second case 422.
  • a valve chamber communicating with these channels is formed.
  • valve body 423 and the coil spring 424 are arranged within the valve chamber. Inside the valve chamber, the valve body 423 is urged toward the flow path of the second case 422 by a coil spring 424 .
  • the valve body 423 closes the opening of the flow path to the valve chamber of the second case 422 due to the biasing force of the coil spring 424, but a force that pushes the valve body 423 toward the first case 421 acts on the valve body 423. Then, the valve body 423 moves toward the first case 421 against the urging force of the coil spring 424, thereby opening the opening of the flow path of the second case 422 on the valve chamber side.
  • the tip of the valve body 423 (the end on the second case 422 side) does not block the opening of the nozzle when the tip of the nozzle of the syringe comes into contact with it, and also ensures that the inside of the syringe and the valve chamber are connected to each other. Shaped for fluid communication.
  • the flow path of the second case 422 has a diameter that allows the nozzle portion of a syringe to be inserted therein.
  • a plurality of ribs 422a are formed on the inner surface of the flow path of the second case 422 at equal intervals in the circumferential direction of the flow path. These ribs 422a function as a stopper for the syringe and prevent the syringe from entering too far into the suction valve 420. Furthermore, these ribs 422a also function as a guide during operation of the valve body 423, thereby allowing the valve body 423 to operate stably.
  • the spike 440 is a part connected to the chemical liquid container, and has a chemical liquid introduction path 440a extending over the entire lengthwise direction.
  • the tip of the spike 440 is formed as a sharp piercing portion 440b, and by passing the piercing portion 440b through the plug member of the liquid medicine container, fluid communication is established between the liquid medicine container and the introduction path 440a.
  • a pair of grippers 440c be integrally provided at the base of the stabbing portion 440b.
  • the gripper 440c may be textured to prevent slipping.
  • an air vent 440d is formed in the piercing portion 440b separately from the introduction path 440a.
  • a filter 441 (not shown in FIGS. 12D and 12E) is attached to the end of the air vent 440d.
  • a Luer lock type connection structure is formed at the end of the second case 422.
  • the opening/closing dust cap 430 is formed with a Luer lock type connection structure that engages with the connection structure of the second case 422.
  • the openable/closable dust cap 430 is detachably connected to the end of the second case 422.
  • a spike cap 450 is detachably attached to the piercing portion 440b of the spike 440.
  • the procedure for using the above-mentioned suction tube unit 400 will be explained.
  • the lid of the retractable dust cap 430 is opened and the spike cap 450 is removed.
  • the spike 440 is pierced into the stopper member of the drug solution container, and then the nozzle portion of the syringe is inserted into the flow path of the suction valve 420.
  • the syringe used is an empty syringe that is not filled with a drug solution, and is a syringe in which the plunger is located at the most advanced position.
  • the plunger of the syringe is moved back to suck the drug solution from the drug solution container into the syringe.
  • the nozzle portion of the syringe is pulled out from the suction valve 420, and the spike 440 is pulled out from the plug member of the medicinal solution container.
  • the valve body 423 is returned to its original position by the biasing force of the coil spring 424, and the suction valve 420 is closed.
  • the syringe connectors 310a and 320a that connect the syringe and the medicinal liquid circuit are not particularly limited in structure as long as the medicinal liquid does not leak during the injection and suction operation of the medicinal liquid, but the syringe connector is prevented from loosening. It is preferable that it has a function.
  • FIG. 13 shows a side view of a syringe connector with a loosening prevention function and a syringe corresponding to the syringe connector.
  • the syringe connector 360 shown in FIG. 13 is a cap-shaped member into which the nozzle portion of the syringe 22 is inserted, and a thread groove that engages with a thread formed on the nozzle portion of the syringe 22 is formed on the inner surface of the syringe connector 360.
  • a connecting member such as a tube or T-shaped pipe is connected to the end of the syringe connector 360 opposite to the side where the nozzle part of the cylinder 22 is inserted through a rotary joint.
  • a plurality of connector protrusions 360a are formed at the end of the syringe connector 360 on the side into which the nozzle portion of the cylinder 22 is inserted.
  • the connector protrusions 360a are arranged at regular intervals in the circumferential direction of the syringe connector 360, and extend in the longitudinal direction of the syringe connector 360 so as to further extend the syringe connector 360.
  • a plurality of syringe protrusions 22c are also formed on the nozzle portion of the syringe 22 and protrude from its outer surface.
  • the syringe protrusion 22c is formed in such a position, shape, and size that it is located between the connector protrusion 360a when the syringe 22 and the syringe connector 360 are connected.
  • the connector protrusion 360a hits the syringe protrusion 22c, and the syringe connector 360 receives resistance from the syringe protrusion 22c.
  • the syringe connector 360 is constructed of materials and dimensions such that when the syringe connector 360 is further rotated, the connector protrusion 360a is elastically deformed and can overcome the syringe protrusion 22c. Therefore, the user can apply greater force to the syringe connector 360 and further rotate the syringe connector 360 to screw it into the nozzle portion of the syringe 22.
  • the connector protrusion 360a is located between the syringe protrusions 22c.
  • it is necessary to apply a force that allows the connector protrusion 360a to elastically deform and overcome the syringe protrusion 22c. It functions as a function to prevent the syringe 22 from loosening.
  • a clicking sensation is given to the user by the connector protrusion 360a climbing over the syringe protrusion 22c.
  • the user can intuitively understand that the syringe connector 360 is screwed into the nozzle portion of the syringe 22.
  • the magnitude of the click feeling can be arbitrarily set by appropriately designing the material of the syringe connector 360, the dimensions of the connector protrusion 360a, and the dimensions of the syringe protrusion 22c.
  • the injection head 10a holds a head main body 101 on which a syringe is mounted, a chemical liquid circuit operating unit 102 arranged in front of the head main body 101 (on the side on which the syringe is mounted), and chemical liquid containers 40A and 40B (see FIG. 1). It has a drug solution container holder 103.
  • (C-a) Head Body The main function of the head body 101 is to mount a syringe and operate the syringe mounted thereon. Therefore, the head main body 101 includes a clamper 111 that removably fixes the two syringes 20A and 20B (see FIG. 1), a presser 112, and an operating section 113, as shown in FIG.
  • the clamper 111 can have a first holding structure 111a and two second holding structures 111b that cooperate with the first holding structure 111a to hold the syringe.
  • the first holding structure 111a has two recesses that receive circumferential portions of the end flange portions of the two syringes (in the form shown in FIG. 3, the cover flanges 21a of the protective cover 21).
  • the second holding structure 111b is arranged to correspond to each recess of the first holding structure 111a, and is configured to have a recess capable of receiving at least a portion of the remaining flange portion received in each recess.
  • the second holding structure 111b is supported movably between an open position and a closed position with respect to the first holding structure 111a, and in the closed position, cooperates with the first holding structure 111a to hold the flange portion of the syringe. It is held immovable in the longitudinal direction.
  • immovable includes not only that the target structure does not move at all, but also that it moves within the range of clearance caused by design dimensional tolerances.
  • the presser 112 is movable forward and backward by a drive source such as a motor, and constitutes a part of the syringe drive mechanism.
  • the tip of the presser 112 has an engaging portion that engages with a plunger (or piston) of a syringe. This engaging portion engages with the plunger (or piston), and by moving the presser 112 forward and backward with the syringe held by the clamper 111, the plunger (or piston) moves forward and backward with respect to the cylinder. do. Thereby, it is possible to inject a medicinal solution from the syringe or to aspirate the medicinal solution into the syringe.
  • the operation unit 113 has a plurality of buttons, such as a forward button and a backward button, for operating the presser 112. 112 can be operated.
  • the head main body 101 can have a support shaft 114 extending in a direction perpendicular to the longitudinal direction of the syringe to be mounted.
  • the head main body 101 can be rotatably supported via the support shaft 114 on a stand (not shown) or a pivot arm (not shown) extending from the ceiling.
  • the head main body 101 By supporting the head main body 101 with the support shaft 114 oriented substantially horizontally, the head main body 101 can be placed in a posture with the tip of the syringe facing the ceiling (upward posture) and with the tip of the syringe facing the floor. It can be supported rotatably between the facing position (downward facing position) and the downward facing position.
  • (C-b) Chemical liquid circuit operating unit The chemical liquid circuit operating unit 102 is detachably attached to the single-use portion 300A (see FIG. 2) of the chemical liquid circuit 30, and controls each flow path of the single-use portion 300A. It has multiple mechanisms. These mechanisms are electrically driven and are housed in a casing, except for the parts necessary for routing the chemical liquid circuit 30, so that the chemical liquid does not come into contact with these mechanisms. There is.
  • the chemical liquid circuit operation unit 102 may be fixed to the head main body 101. By fixing the chemical liquid circuit operating unit 102 to the head main body 101, the chemical liquid circuit 30 can be arranged in an orderly manner without bending the tubes forming the chemical liquid circuit 30.
  • Mechanisms included in the chemical liquid circuit operating unit 102 include air sensors 710, 780, crushing mechanisms 720, 730, 750, and flow path opening/closing valve drive mechanism 740. The operations of these are controlled by the injection control unit 11 of the console 10b (see FIG. 1). Further, these positions are shown in FIG.
  • Air Sensor detects air in the flow path.
  • two air sensors 710 detect the presence of air within the second tubes 315a, 325b of the first and second main lines 301a, 302a of the chemical circuit 30, respectively.
  • Air sensor 780 detects the presence of air within eighth tube 340 of transducer line 304 of chemical circuit 30 .
  • any known sensor can be used as long as it can detect air inside the tube.
  • An example of an air sensor is an ultrasonic sensor having a transmitter and a receiver placed opposite each other with a tube in between.
  • the squishing mechanisms 720, 730, and 750 control opening and closing of the flow path by operating to crush and open the tube.
  • the squeezing mechanism 720, 730 can be placed near the air sensor 710, 780. As long as it is near the air sensors 710, 780, the crushing mechanisms 720, 730 may be placed upstream or downstream of the air sensors 710, 780. In order to perform a closing operation that effectively prevents air from reaching the subject by controlling the crushing mechanisms 720, 730 when air is detected by the air sensors 710, 780, it is necessary to It is preferable that crushing mechanisms 720 and 730 are arranged (on the downstream side). A crushing mechanism 750 can be disposed on the sixth tube 335.
  • the crushing mechanism 720, 730, 750 can have, for example, a base on which the tube is placed, and a pushing member slidably supported by the base. With the tube placed on the base, the push member can be moved toward the base and the tube can be crushed by the base and the push member to close the flow path.
  • the passage opening/closing valve driving mechanism 740 is equipped with a passage opening/closing valve 332 (see FIG. 4, etc.) and drives the passage opening/closing valve 332. This is a mechanism for opening and closing the flow path within 332.
  • the structure of the flow path opening/closing valve drive mechanism 740 is not particularly limited as long as it can control the opening and closing of the flow path.
  • the device may include a hook, which is an engaging portion that engages with the piston 502 (see FIG. 4), and a mechanism for moving the hook.
  • the flow path on-off valve drive mechanism 740 can further include a sensor that detects whether or not the flow path on-off valve 332 is attached to the flow path on-off valve drive mechanism 740 .
  • a sensor is not particularly limited, and any sensor that can detect that the flow path opening/closing valve 332 attached to the flow path opening/closing valve drive mechanism 740 is attached can be used.
  • a crushing mechanism 730 is arranged in the transducer line 304, but instead, a flow path opening/closing valve 332 is arranged in the transducer line 304, and the crushing mechanism 730 is used as a flow path opening/closing valve. 332 may be substituted.
  • the chemical liquid circuit operation unit 102 can have a lighting module that illuminates the flow path on-off valve 332 attached to the flow path on-off valve drive mechanism 740. This makes it easier to visually recognize the channel opening/closing valve 332 attached to the chemical liquid circuit operation unit 102.
  • the lighting module includes a light source, and the lighting method by the lighting module may be arbitrary. As the light source, any light source such as a light emitting diode can be used. It is preferable that the lighting module illuminates the flow path on-off valve only when the flow path on-off valve is attached to the flow path on-off valve drive mechanism. Thereby, the user can easily visually recognize that the channel opening/closing valve is attached to the channel opening/closing valve drive mechanism.
  • the drug solution container holder 103 detachably holds the drug solution containers 40A and 40B, and can be attached to the injection head 10a or the drug solution circuit operation unit 102 in a suspended manner.
  • the chemical liquid container holder 103 may include an air sensor 841 that detects air in the first subline 301b and the second subline 302b shown in FIG. 2.
  • the air sensor 841 any sensor such as an ultrasonic air sensor can be used.
  • the crushing mechanism is opened means that the crushing mechanism is driven so that the flow path is opened between the upstream side and the downstream side thereof.
  • the crushing mechanism is closed means that the crushing mechanism is driven such that the flow path is closed between its upstream and downstream sides.
  • the operation of the crushing mechanism 730 in the following description can be read as the operation of the replaced flow path opening/closing valve driving mechanism 740. I can do it.
  • (D-d) Injection condition setting screen (check, standby, start OK)
  • the A-side and B-side crushing mechanisms 720 are closed. Further, the flow path opening/closing valve 332 is closed, and the crushing mechanism 730 of the transducer line 304 and the crushing mechanism 750 of the sixth tube 335 are opened.
  • the opening and closing timing of the crushing mechanism 730 of the transducer line 304 it is preferable to close it in accordance with the injection timing within a pressure range in which the transducer is protected. If there is residual pressure after injection, it may be opened a predetermined time after injection to avoid the influence of the residual pressure.
  • (e4) Advance A When the advance button on the A side of the injection head 10a is operated (that is, when the plunger of the syringe on the A side is manually advanced), while the operation is being performed, the A side The crushing mechanism 720 on the B side is opened, and the crushing mechanism 720 on the B side is closed. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.

Abstract

Provided is a mechanical component such as a flow path opening/closing valve that is suitable for use in a chemical circuit and capable of stably operating even under high pressure. A flow path opening/closing valve 332 has: a housing 501 that comprises an inlet path and outlet path; a piston 502 that is freely slidably inserted within the housing 501 so as to be capable of achieving an open position and closed position; and a stopper structure 503 having a protrusion that limits the movement range of the piston 502 and a recess that extends in the sliding direction of the piston 502 and receives the protrusion. The recess has a length that is established such that the recess has a first end against which the protrusion abuts when the piston 502 is located in the open position and a second end against which the protrusion abuts when the piston 502 is located in the closed position. One from among the housing 501 and the piston 502 has a protrusion formed thereon, and the other has a recess formed therein.

Description

薬液回路用流路開閉弁、および該流路開閉弁を備える薬液回路A flow path opening/closing valve for a chemical liquid circuit, and a chemical liquid circuit equipped with the flow path opening/closing valve.
　本発明は、複数のチューブ等を含む薬液回路に用いられる流路開閉弁、および該流路開閉弁を備える薬液回路に関する。 The present invention relates to a flow path opening/closing valve used in a chemical liquid circuit including a plurality of tubes, etc., and a chemical liquid circuit equipped with the flow path opening/closing valve.
　被検者に薬液を注入するのに薬液注入装置が用いられることが多い。多くの薬液注入装置は、所望の注入速度での注入が容易である観点から、シリンジを着脱自在に装着し、シリンジと被検者とを流体的に接続する薬液回路を介して、シリンジに充填された薬液を注入するように構成されている。 A drug injection device is often used to inject a drug into a subject. From the viewpoint of easy injection at a desired injection rate, many drug injection devices attach a syringe detachably and fill the syringe through a drug circuit that fluidly connects the syringe and the subject. The device is configured to inject a medicinal solution.
　シリンジは、原則的には単数回しか使用されないが、ボトルからシリンジへ薬液を再充填して複数回使用されることも多い。その場合、注入回路は、シリンジから被検者へ通じる被検者ラインと、被検者ラインから分岐してボトルへ通じるボトルラインとを有する。薬液の注入時にはボトルラインは閉鎖されるが、薬液の充填時には、ボトルラインの分岐部より下流側で被検者ラインが閉鎖された後、ボトルラインが開かれる。この際、被検者ラインを逆流する被検者の血液（逆血）が被検者ラインの閉鎖部よりも上流側に到達しないようにすることが重要である。 In principle, a syringe is used only once, but it is often used multiple times by refilling the syringe with drug solution from the bottle. In that case, the injection circuit has a subject line leading from the syringe to the subject, and a bottle line branching from the subject line and leading to the bottle. The bottle line is closed when a drug solution is injected, but when a drug solution is filled, the bottle line is opened after the subject line is closed downstream from the branch of the bottle line. At this time, it is important to prevent the subject's blood flowing backward through the subject line (reverse blood) from reaching the upstream side of the closed part of the subject line.
　そのような血液の逆流をよりより確実に防止できる薬液回路として、例えば特許文献１（国際公開第２０１８／１８１２７０号）には、上記の閉鎖部が、流路を有する第１移動部材と、流路を有し前記第１移動部材よりも被検者ラインの下流側に位置する第２移動部材と、前記第１移動部材および前記第２移動部材を摺動可能に収容するハウジングとを備え、前記第１移動部材の流路を開放した後に、前記第２移動部材の流路が開放されるように構成されている薬液回路が開示されている。 For example, in Patent Document 1 (International Publication No. 2018/181270), as a medical liquid circuit that can more reliably prevent such backflow of blood, the above-mentioned closing part is connected to a first moving member having a flow path and a flow path. a second moving member having a path and located downstream of the subject line than the first moving member, and a housing that slidably accommodates the first moving member and the second moving member, A chemical liquid circuit is disclosed in which the flow path of the second moving member is opened after the flow path of the first moving member is opened.
国際公開第２０１８／１８１２７０号International Publication No. 2018/181270
　薬液回路は、１回または複数回使用されるごとに取り換えられる消耗品であるが、薬液の流路となるチューブのみならず、薬液の流れの制御のための開閉弁やコネクタなど、様々な部品が用いられる。また、薬液回路では造影剤が薬液として用いられることが多く、薬液回路には例えば２．０７×１０６～８．２７×１０６Ｐａ（３００～１２００ｐｓｉ）といった高圧が作用する。そのため、薬液回路を構成する各部品、特に動作を伴う機構部品は、高圧においても安定して動作することが求められ、例えば流路開閉弁においては高い圧力が作用しても薬液の漏れが生じないことが重要である。そこで本発明は、高圧においても安定して動作しうる、薬液回路に使用されるのに適した流路開閉弁のような機構部品を提供することを目的とする。 Chemical liquid circuits are consumables that are replaced each time they are used once or multiple times, and they include not only tubes that serve as flow paths for chemical liquids, but also various parts such as on-off valves and connectors for controlling the flow of chemical liquids. is used. Further, in the chemical liquid circuit, a contrast medium is often used as the chemical liquid, and a high pressure of, for example, 2.07×10 6 to 8.27×10 6 Pa (300 to 1200 psi) acts on the chemical liquid circuit. Therefore, each component that makes up the chemical liquid circuit, especially the mechanical parts that involve movement, is required to operate stably even under high pressure.For example, in a flow path opening/closing valve, even if high pressure is applied, chemical liquid may leak. It is important that there is no Therefore, an object of the present invention is to provide a mechanical component such as a flow path opening/closing valve that is suitable for use in a chemical liquid circuit and can operate stably even under high pressure.
　本発明の一態様によれば、
　薬液回路に用いられる流路開閉弁であって、
　流入路および排出路を備えたハウジングと、
　開位置および閉位置を取り得るように前記ハウジング内にスライド自在に挿入されたピストンと、
　前記ハウジングに対する前記ピストンの移動範囲を制限する、凸部と、前記ピストンのスライド方向に延びて前記凸部を受け入れる凹部とを有するストッパ構造と、
　を有し、
　前記凹部は、前記ピストンが前記開位置に位置するときに前記凸部が当接する第１端部と、前記ピストンが前記閉位置に位置するときに前記凸部が当接する第２端部とを有するように長さが定められ、かつ、
　前記ハウジングおよび前記ピストンの一方に前記凸部が形成され、他方に前記凹部が形成されている、
流路開閉弁が提供される。 According to one aspect of the invention,
A flow path opening/closing valve used in a chemical liquid circuit,
a housing with an inlet and an outlet;
a piston slidably inserted into the housing so as to be capable of assuming open and closed positions;
a stopper structure having a convex portion that limits a movement range of the piston relative to the housing, and a recess that extends in a sliding direction of the piston and receives the convex portion;
has
The concave portion has a first end portion that the convex portion abuts when the piston is in the open position, and a second end portion that the convex portion abuts when the piston is in the closed position. the length is determined so as to have, and
The convex portion is formed on one of the housing and the piston, and the concave portion is formed on the other.
A flow path opening/closing valve is provided.
　（用語の定義）
　本明細書において、「上流」および「下流」は、薬液の流れ方向に対する「上流」および「下流」を意味する。ただし、薬液の注入および吸引のように薬液が双方向に流れ得る場合は、特に断りがない限り、薬液の注入時の薬液の流れ方向に対する「上流」および「下流」を意味する。 (Definition of terms)
As used herein, "upstream" and "downstream" mean "upstream" and "downstream" with respect to the flow direction of the drug solution. However, in cases where the medicinal solution can flow in both directions, such as during injection and aspiration of the medicinal solution, unless otherwise specified, "upstream" and "downstream" with respect to the flow direction of the medicinal solution during injection of the medicinal solution are meant.
　本発明によれば、高圧でも安定して動作しうる、薬液回路での使用に適した機構部品を提供することができる。 According to the present invention, it is possible to provide a mechanical component suitable for use in a chemical liquid circuit that can operate stably even under high pressure.
本発明の一実施形態による医用画像撮像システムの概略図である。1 is a schematic diagram of a medical image capture system according to an embodiment of the invention. FIG. 図１に示す薬液回路の概略図である。2 is a schematic diagram of the chemical liquid circuit shown in FIG. 1. FIG. 図１に示す薬液注入装置に使用できるシリンジの一形態の分解斜視図である。FIG. 2 is an exploded perspective view of one form of a syringe that can be used in the liquid drug injection device shown in FIG. 1. FIG. 図２に示す流路開閉弁の一形態の斜視図である。FIG. 3 is a perspective view of one form of the flow path opening/closing valve shown in FIG. 2. FIG. 図４に示す流路開閉弁のハウジングの斜視図である。FIG. 5 is a perspective view of the housing of the flow path on-off valve shown in FIG. 4. FIG. 図５に示すハウジングの５Ａ－５Ａ線断面斜視図である。6 is a cross-sectional perspective view taken along line 5A-5A of the housing shown in FIG. 5. FIG. 図４に示す流路開閉弁のピストンの斜視図である。FIG. 5 is a perspective view of a piston of the flow path opening/closing valve shown in FIG. 4; 図６に示すピストンの６Ａ－６Ａ線断面斜視図である。7 is a cross-sectional perspective view taken along line 6A-6A of the piston shown in FIG. 6. FIG. 図６に示すピストンの６Ｂ－６Ｂ線断面斜視図である。7 is a cross-sectional perspective view taken along line 6B-6B of the piston shown in FIG. 6. FIG. 図４に示す流路開閉弁の、開位置および閉位置における７Ａ－７Ａ線断面図である。FIG. 5 is a sectional view taken along line 7A-7A of the flow path opening/closing valve shown in FIG. 4 at an open position and a closed position. 図４に示す流路開閉弁の、開位置および閉位置における７Ｂ－７Ｂ線断面図である。FIG. 5 is a sectional view taken along line 7B-7B of the flow path opening/closing valve shown in FIG. 4 at an open position and a closed position. 図７Ｂに示すストッパ機構を拡大して示す、図７Ｂと同様の断面図である。FIG. 7B is a cross-sectional view similar to FIG. 7B, showing an enlarged view of the stopper mechanism shown in FIG. 7B. 薬液回路に用いることのできる一方弁の形態１の斜視図である。FIG. 2 is a perspective view of a first embodiment of a one-way valve that can be used in a chemical liquid circuit. 図８Ａに示す一方弁の分解斜視図である。FIG. 8A is an exploded perspective view of the one-way valve shown in FIG. 8A. 図８Ａに示す一方弁の８Ｃ－８Ｃ線断面図である。FIG. 8C is a sectional view taken along line 8C-8C of the one-way valve shown in FIG. 8A. 図８Ａに示す一方弁の第１ケースの斜視図である。8A is a perspective view of the first case of the one-way valve shown in FIG. 8A. FIG. 図８Ａに示す一方弁の第２ケースの斜視図である。8A is a perspective view of a second case of the one-way valve shown in FIG. 8A. FIG. 薬液回路に用いられる一方弁の形態２の、閉じた状態を示す断面図である。FIG. 7 is a sectional view showing a closed state of a second one-way valve used in a chemical liquid circuit. 薬液回路に用いることのできる一方弁の形態２の、開いた状態を示す断面図である。FIG. 7 is a cross-sectional view showing a second type of one-way valve that can be used in a chemical liquid circuit in an open state. 薬液回路に用いることができる一方弁の形態３の斜視図である。It is a perspective view of the form 3 of a one-way valve which can be used for a chemical liquid circuit. 図１０Ａに示す一方弁の分解斜視図である。FIG. 10B is an exploded perspective view of the one-way valve shown in FIG. 10A. 図１０Ａに示す一方弁の断面図である。FIG. 10A is a cross-sectional view of the one-way valve shown in FIG. 10A. 薬液回路に用いることができる一方弁の形態４の斜視図である。It is a perspective view of the form 4 of a one-way valve which can be used for a chemical liquid circuit. 図１１Ａに示す一方弁の分解斜視図である。FIG. 11B is an exploded perspective view of the one-way valve shown in FIG. 11A. 図１１Ａに示す一方弁の断面図である。FIG. 11A is a cross-sectional view of the one-way valve shown in FIG. 11A. 薬液回路に用いることができる吸引チューブユニットの斜視図である。FIG. 2 is a perspective view of a suction tube unit that can be used in a chemical liquid circuit. 図１２に示す吸引チューブユニットの吸引弁の斜視図である。13 is a perspective view of the suction valve of the suction tube unit shown in FIG. 12. FIG. 図１２Ａに示す吸引弁の分解斜視図である。FIG. 12A is an exploded perspective view of the suction valve shown in FIG. 12A. 図１２Ａに示す吸引弁の１２Ｃ－１２Ｃ線断面斜視図である。FIG. 12C is a cross-sectional perspective view taken along line 12C-12C of the suction valve shown in FIG. 12A. 図１２Ａに示す吸引チューブユニットのスパイクの斜視図である。FIG. 12B is a perspective view of the spike of the suction tube unit shown in FIG. 12A. 図１２Ａに示すスパイクの１２Ｅ－１２Ｅ線断面斜視図である。12E is a cross-sectional perspective view taken along line 12E-12E of the spike shown in FIG. 12A. FIG. シリンジコネクタおよびシリンジの変形例の、一部を断面で示した側面図である。FIG. 7 is a partially cross-sectional side view of a modified example of a syringe connector and a syringe. 図１に示す医用画像撮像システムの注入ヘッドの構成を示すブロック図である。2 is a block diagram showing the configuration of an injection head of the medical image capturing system shown in FIG. 1. FIG. 図１４に示す注入ヘッドのヘッド本体の斜視図である。15 is a perspective view of the head main body of the injection head shown in FIG. 14. FIG.
　以下、本発明の実施形態について図面を参照して説明する。ここでは、冠動脈造影による心臓カテーテル検査などに好ましく用いられるアンギオ撮像システムを例に挙げて説明するが、本発明はこれに限定されるものではなく、ＣＴ（Ｃｏｍｐｕｔｅｄ　Ｔｏｍｏｇｒａｐｈｙ）撮像システム、ＭＲＩ（Ｍａｇｎｅｔｉｃ　Ｒｅｓｏｎａｎｃｅ　Ｉｍａｇｉｎｇ）システム、ＰＥＴ（Ｐｏｓｉｔｒｏｎ　Ｅｍｉｓｓｉｏｎ　Ｔｏｍｏｇｒａｐｈｙ）システムなどにも適用可能である。 Hereinafter, embodiments of the present invention will be described with reference to the drawings. Here, an angio imaging system that is preferably used for cardiac catheterization using coronary angiography will be described as an example, but the present invention is not limited to this. It is also applicable to PET (Positron Emission Tomography) systems, etc.
　［Ａ］全体構成
　図１を参照すると、薬液注入装置１０と、薬液回路３０と、医用画像撮像装置５０と、を有する本発明の一実施形態による医用画像撮像入システムの概略図が示されている。薬液注入装置１０は、注入ヘッド１０ａとコンソール１０ｂとを有する。薬液回路３０は、注入ヘッド１０ａと被検者とを流体的に接続する。薬液注入装置１０と医用画像撮像装置５０とは、相互間でデータの送受信を行うことができるように互いに接続されることができる。両者の接続は、有線接続であってもよいし無線接続であってもよい。 [A] Overall Configuration Referring to FIG. 1, there is shown a schematic diagram of a medical image capture system according to an embodiment of the present invention, which includes a drug solution injection device 10, a drug solution circuit 30, and a medical image capture device 50. There is. The chemical liquid injection device 10 includes an injection head 10a and a console 10b. The chemical liquid circuit 30 fluidly connects the injection head 10a and the subject. The liquid drug injection device 10 and the medical image capturing device 50 can be connected to each other so that data can be transmitted and received between them. The connection between the two may be a wired connection or a wireless connection.
　医用画像撮像装置５０は、撮像動作を実行する撮像動作ユニット５２と、撮像動作ユニット５２の動作を制御する撮像制御ユニット５１と、を有しており、薬液注入装置１０によって薬液が注入された被検者の断層画像および／または三次元画像を含む医用画像を取得することができる。撮像動作ユニット５２は、通常、被検者用の寝台、寝台上の所定の空間に電磁波を照射する電磁波照射ユニット等を有する。撮像制御ユニット５１は、撮像条件を決定したり、決定した撮像条件に従って撮像動作ユニット５２の動作を制御したりする等、医用画像撮像装置全体の動作を制御する。撮像制御ユニット５１は、いわゆるマイクロコンピュータを含んで構成することができ、ＣＰＵ、ＲＯＭ、ＲＡＭ、他の機器とのインターフェースを有することができる。ＲＯＭには、医用画像撮像装置５０の制御用のコンピュータプログラムが実装されている。ＣＰＵは、このコンピュータプログラムに対応して各種機能を実行することで、医用画像撮像装置５０の各部の動作を制御する。 The medical image capturing apparatus 50 includes an imaging operation unit 52 that executes an imaging operation and an imaging control unit 51 that controls the operation of the imaging operation unit 52. Medical images including tomographic images and/or three-dimensional images of the examiner can be acquired. The imaging operation unit 52 usually includes a bed for the subject, an electromagnetic wave irradiation unit that irradiates electromagnetic waves to a predetermined space above the bed, and the like. The imaging control unit 51 controls the operation of the entire medical image capturing apparatus, such as determining imaging conditions and controlling the operation of the imaging operation unit 52 according to the determined imaging conditions. The imaging control unit 51 can be configured to include a so-called microcomputer, and can have a CPU, ROM, RAM, and interfaces with other devices. A computer program for controlling the medical image capturing apparatus 50 is installed in the ROM. The CPU controls the operation of each part of the medical image capturing apparatus 50 by executing various functions in accordance with this computer program.
　医用画像撮像装置５０は、撮像条件や取得した医用画像などを表示できる液晶ディスプレイなどの表示デバイス５４、および撮像条件などを入力するための入力デバイス５３をさらに含むことができる。入力デバイス５３としては、各種ボタン、キーボードおよびマウスなど公知の入力デバイスの少なくとも１種を用いることができる。撮像条件を決定するのに用いられるデータの少なくとも一部は入力デバイス５３から入力され、撮像制御ユニット５１に送信される。表示デバイス５４に表示されるデータは撮像制御ユニット５１から送信される。また、表示デバイスであるディスプレイ上に入力デバイスとしてタッチスクリーンを配置したタッチパネルを入力デバイス５３および表示デバイス５４として用いることもできる。入力デバイス５３の一部、表示デバイス５４および撮像制御ユニット５１は、医用画像撮像装置用のコンソールとして一つの筐体に組み込むことができる。 The medical image capturing apparatus 50 can further include a display device 54 such as a liquid crystal display that can display imaging conditions, acquired medical images, etc., and an input device 53 for inputting imaging conditions and the like. As the input device 53, at least one kind of known input devices such as various buttons, a keyboard, and a mouse can be used. At least part of the data used to determine the imaging conditions is input from the input device 53 and sent to the imaging control unit 51. Data displayed on the display device 54 is transmitted from the imaging control unit 51. Further, a touch panel in which a touch screen is disposed as an input device on a display that is a display device can also be used as the input device 53 and the display device 54. A portion of the input device 53, the display device 54, and the imaging control unit 51 can be incorporated into one housing as a console for the medical image capturing apparatus.
　薬液注入装置１０は、シリンジに充填された薬液を、薬液回路３０を介して被検者の血管内に注入するのに使用される装置である。シリンジは注入ヘッド１０ａに着脱自在に搭載され、シリンジのプランジャ（またはピストン）を操作する少なくとも１つのシリンジ駆動機構が注入ヘッド１０ａに内蔵されている。本形態では、注入ヘッド１０aは、例えば造影剤および生理食塩水といった２種類の薬液を別々にまたは同時に注入できるように、２つのシリンジ２０Ａ、２０Ｂを搭載できるように構成され、また、各シリンジ２０Ａ、２０Ｂを独立して操作する２つのシリンジ駆動機構を有している。しかし、一方の薬液注入のためのシリンジ駆動機構および他方の薬液注入のためのシリンジ駆動機構の少なくとも一方が複数であってもよい。 The drug solution injection device 10 is a device used to inject a drug solution filled in a syringe into a blood vessel of a subject via a drug solution circuit 30. The syringe is removably mounted on the injection head 10a, and at least one syringe drive mechanism for operating the plunger (or piston) of the syringe is built into the injection head 10a. In this embodiment, the injection head 10a is configured to be able to mount two syringes 20A and 20B so that two types of medical solutions, such as a contrast medium and physiological saline, can be injected separately or simultaneously. , 20B have two syringe drive mechanisms that independently operate the syringes. However, at least one of the syringe drive mechanism for injecting one drug solution and the other syringe drive mechanism for injecting a drug solution may be plural.
　ここで、本形態で用いることのできるシリンジの一形態について図３を参照して説明する。図示したシリンジは、一般にロッドレスシリンジと呼ばれるものであり、末端および先端にそれぞれフランジ２２ａおよびノズル部２２ｂが形成されたシリンダ２２と、シリンダ２２内に進退移動可能に挿入されたプランジャ２３とを有している。プランジャ２３の末端には、注入ヘッド１０ａのシリンジ駆動機構と係合するフランジ状の凸部（不図示）が一体に形成されている。シリンジは、薬液が充填された状態でメーカーから提供されるプレフィルドタイプのシリンジであってもよいし、医療現場で薬液を充填した現場充填タイプのシリンジであってもよい。 Here, one form of a syringe that can be used in this embodiment will be described with reference to FIG. 3. The illustrated syringe is generally called a rodless syringe, and includes a cylinder 22 having a flange 22a and a nozzle portion 22b formed at its distal end and tip, respectively, and a plunger 23 inserted into the cylinder 22 so as to be movable forward and backward. are doing. A flange-shaped convex portion (not shown) that engages with the syringe drive mechanism of the injection head 10a is integrally formed at the end of the plunger 23. The syringe may be a prefilled syringe provided by a manufacturer filled with a medical solution, or it may be an on-site filling type syringe filled with a medical solution at a medical site.
　シリンジは、保護カバー２１に挿入されて注入ヘッド１０ａに装着される。保護カバー２１は、薬液注入中のシリンダ２２の内圧上昇による膨張を抑制するために、シリンダ２２の外周面と保護カバー２１の内周面との間に実質的に隙間が生じない寸法で円筒状に構成された部品である。保護カバー２１がこの役割を果たすために、保護カバー２１は、薬液注入中にシリンダ２２に作用する内圧に十分に耐え得る機械的強度を有する肉厚で形成されている。 The syringe is inserted into the protective cover 21 and attached to the injection head 10a. The protective cover 21 has a cylindrical shape with a size that substantially leaves no gap between the outer circumferential surface of the cylinder 22 and the inner circumferential surface of the protective cover 21 in order to suppress expansion due to an increase in the internal pressure of the cylinder 22 during injection of the chemical solution. It is a part composed of. In order for the protective cover 21 to play this role, the protective cover 21 is formed with a wall thickness that has sufficient mechanical strength to withstand the internal pressure that acts on the cylinder 22 during injection of the chemical solution.
　保護カバー２１の先端には開口部が形成されており、シリンダ２２は、この開口部からノズル部２２ｂを突出させた状態で保護カバー２１に挿入される。保護カバー２１の末端には、シリンダ２２のフランジ２２ａを受け入れるリング状の凹部が形成されたカバーフランジ２１ａが形成されている。本形態では、シリンジが保護カバー２１に挿入されて使用されるが、保護カバー２１は本発明においては必須ではなく、シリンジが注入ヘッド１０ａに直接装着されてもよい。 An opening is formed at the tip of the protective cover 21, and the cylinder 22 is inserted into the protective cover 21 with the nozzle portion 22b protruding from this opening. A cover flange 21a is formed at the end of the protective cover 21 and has a ring-shaped recess for receiving the flange 22a of the cylinder 22. In this embodiment, the syringe is used by being inserted into the protective cover 21, but the protective cover 21 is not essential in the present invention, and the syringe may be directly attached to the injection head 10a.
　再び図１を参照すると、コンソール１０ｂは、注入制御ユニット１１、入力デバイス１２および表示デバイス１３を有する。注入制御ユニット１１は、入力デバイス１２から入力されたデータの少なくとも一部を用いて薬液の注入量および注入速度等の注入条件を決定したり、決定した注入条件に従って薬液が注入されるように注入ヘッド１０ａの動作を制御したり、表示デバイス１３の表示を制御したりするなど、薬液注入装置全体の動作を制御する。注入制御ユニット１１は、いわゆるマイクロコンピュータを含んで構成することができ、ＣＰＵ、ＲＯＭ、ＲＡＭ、他の機器とのインターフェースを有することができる。ＲＯＭには、薬液注入装置１０の制御用のコンピュータプログラムが実装されている。ＣＰＵは、このコンピュータプログラムに対応して各種機能を実行することで、薬液注入装置１０の各部の動作を制御することができる。 Referring again to FIG. 1, the console 10b has an injection control unit 11, an input device 12 and a display device 13. The injection control unit 11 uses at least part of the data input from the input device 12 to determine injection conditions such as the injection amount and injection speed of the drug solution, and performs injection so that the drug solution is injected according to the determined injection conditions. It controls the operation of the entire chemical liquid injector, such as controlling the operation of the head 10a and controlling the display of the display device 13. The injection control unit 11 can be configured to include a so-called microcomputer, and can have a CPU, ROM, RAM, and interfaces with other devices. A computer program for controlling the liquid drug injection device 10 is installed in the ROM. The CPU can control the operation of each part of the liquid drug injection device 10 by executing various functions in accordance with this computer program.
　入力デバイス１２は、注入制御ユニット１１で薬液の注入条件を決定するのに用いられるデータなどを入力するのに用いられるデバイスである。入力デバイス１２としては、例えば、各種ボタン、キーボードおよびマウスなど公知の入力デバイスの少なくとも１種を用いることができる。入力デバイス１２から入力されたデータは注入制御ユニット１１に送信され、表示デバイス１３に表示されるデータは注入制御ユニット１１から送信される。表示デバイス１３は、注入制御ユニット１１によって制御されて、薬液の注入条件の決定に必要なデータ等の表示、注入プロトコルの表示、注入動作の表示、各種ガイダンスの表示、および各種警告の表示などを行う。 The input device 12 is a device used to input data and the like used for determining the injection conditions of the drug solution in the injection control unit 11. As the input device 12, for example, at least one kind of known input devices such as various buttons, a keyboard, and a mouse can be used. Data input from the input device 12 is sent to the injection control unit 11, and data displayed on the display device 13 is sent from the injection control unit 11. The display device 13 is controlled by the injection control unit 11, and displays data necessary for determining injection conditions of the drug solution, injection protocols, injection operations, various guidances, and various warnings. conduct.
　注入プロトコルとは、どのような薬液を、どれだけの量、どれくらいの速度で注入するかを示すものである。注入速度は、一定であってもよいし、時間とともに変化するものであってもよい。また、複数種の薬液、例えば造影剤と生理食塩水とを注入する場合、それらの薬液をどのような順序で注入するかといった情報も注入プロトコルに含まれる。注入プロトコルは、公知の任意の注入プロトコルを用いることができる。また、注入プロトコルの設定手順についても、公知の手順を用いることができるし、設定された注入プロトコルをユーザが任意に変更可能とすることもできる。また、注入プロトコルは、注入圧力の許容最大値（圧力リミット）を含むこともある。圧力リミットが設定された場合は、注入動作中、注入圧力が監視され、注入圧力が、設定された圧力リミットを超えないように注入ヘッド１０ａの動作が制御される。 The injection protocol indicates what kind of drug solution is to be injected, in what amount, and at what speed. The injection rate may be constant or may vary over time. Furthermore, when injecting multiple types of medical solutions, for example, a contrast medium and physiological saline, the injection protocol also includes information such as in what order these medical solutions should be injected. Any known injection protocol can be used as the injection protocol. Furthermore, a known procedure can be used for setting the injection protocol, and the set injection protocol can be changed arbitrarily by the user. The injection protocol may also include maximum allowable injection pressures (pressure limits). If a pressure limit is set, the injection pressure is monitored during the injection operation, and the operation of the injection head 10a is controlled so that the injection pressure does not exceed the set pressure limit.
　表示デバイス１３としては、例えば液晶ディスプレイ装置等、公知の表示装置であってよい。また、表示デバイスであるディスプレイ上に入力デバイスとしてタッチスクリーンを配置したタッチパネルを入力デバイス１２および表示デバイス１３として用いることもできる。入力デバイス１２の一部は、コンソールとは別に設けられてもよい。 The display device 13 may be a known display device such as a liquid crystal display device. Further, a touch panel in which a touch screen is disposed as an input device on a display that is a display device can also be used as the input device 12 and the display device 13. Some of the input devices 12 may be provided separately from the console.
　薬液回路３０は、シリンジと被検者とを連絡する液体の流路構成し、少なくとも１本のチューブ、少なくとも１つのコネクタおよび少なくとも１つのバルブを有することができる。 The chemical liquid circuit 30 constitutes a liquid flow path that communicates the syringe and the subject, and can include at least one tube, at least one connector, and at least one valve.
　［Ｂ］薬液回路の構成
　図１に示す薬液注入装置１０に好適に用いることのできる薬液回路３０の一形態を図２に示す。図２に示す薬液回路３０は、シリンジ２０Ａ、２０Ｂが接続され、各シリンジ２０Ａ、２０Ｂにそれぞれ収容されている第１薬液および第２薬液を被検者に注入する際に用いられる。また、薬液回路３０は、それぞれ第１薬液および第２薬液を収容する第１容器４０Ａおよび第２容器４０Ｂも接続することができ、第１容器４０Ａおよび第２容器４０Ｂから各シリンジ２０Ａ、２０Ｂにそれぞれ第１薬液および第２薬液を吸引することもできる。第１薬液および第２薬液は、医療用の薬液であり、以下では第１薬液が造影剤であり、第２薬液が生理食塩水である場合について説明する。 [B] Configuration of Chemical Liquid Circuit FIG. 2 shows one form of a chemical liquid circuit 30 that can be suitably used in the chemical liquid injection device 10 shown in FIG. 1. The chemical liquid circuit 30 shown in FIG. 2 is connected to the syringes 20A and 20B, and is used when injecting the first medical liquid and the second medical liquid contained in the syringes 20A and 20B, respectively, into the subject. Further, the chemical liquid circuit 30 can also be connected to a first container 40A and a second container 40B which respectively contain a first chemical liquid and a second medical liquid, and connect the first container 40A and the second container 40B to each syringe 20A, 20B. It is also possible to suck the first medical liquid and the second medical liquid, respectively. The first medical liquid and the second medical liquid are medical medical liquids, and a case will be described below in which the first medical liquid is a contrast agent and the second medical liquid is physiological saline.
　薬液回路３０は、造影剤が収容されるシリンジ２０Ａと接続される第１メインライン３０１ａ、生理食塩水が収容されるシリンジ２０Ｂと接続される第２メインライン３０２ａ、造影剤が収容される第１容器４０Ａと接続される第１サブライン３０１ｂ、生理食塩水が収容される第２容器４０Ｂと接続される第２サブライン３０２ｂ、第１メインライン３０１ａの下流に位置する被検者ライン３０３およびトランスデューサと接続されるトランスデューサライン３０４を有する。 The chemical liquid circuit 30 includes a first main line 301a connected to a syringe 20A containing a contrast medium, a second main line 302a connected to a syringe 20B containing physiological saline, and a first main line 302a connected to a syringe 20B containing a contrast medium. A first sub-line 301b connected to the container 40A, a second sub-line 302b connected to the second container 40B containing physiological saline, and connected to the subject line 303 located downstream of the first main line 301a and the transducer. A transducer line 304 is provided.
　ここで「ライン」とは、液体が流れる流路を意味し、液体が流れる各部材（例えば、各種チューブ、Ｔ字管、各種流体コネクタ、各種バルブ、ミキシングデバイスなど）を備える。また、図２では、各ラインは図示のために便宜的に表されており、各ラインの相対的な長さは、実際のラインの相対的な長さを表すものではない。また、「ライン」を構成する部品の１つである「チューブ」について、以下の説明で使用する用語「チューブ」は、１本のチューブ部材で構成されてもよいし、複数のチューブ部材を接続したチューブアセンブリで構成されてもよい。 Here, the term "line" refers to a channel through which a liquid flows, and includes various members through which the liquid flows (for example, various tubes, T-shaped pipes, various fluid connectors, various valves, mixing devices, etc.). Furthermore, in FIG. 2, each line is shown for convenience of illustration, and the relative length of each line does not represent the relative length of the actual line. In addition, regarding the "tube" which is one of the parts constituting the "line", the term "tube" used in the following explanation may be composed of a single tube member, or may be composed of a plurality of tube members connected together. The tube assembly may be made up of a tube assembly.
　第１メインライン３０１ａは、上流側から順に、シリンジコネクタ３１０ａ、Ｔ字管３１１ａ、第１チューブ３１２ａ、回転高圧アダプタ３１３ａ、雌ルアーロックコネクタ３１４ａおよび第２チューブ３１５ａを有する。シリンジコネクタ３１０ａは、回転式のジョイントを介してＴ字管３１１ａと回転自在に接続されており、シリンジ２０Ａが着脱自在に接続される。回転高圧アダプタ３１３ａおよび雌ルアーロックコネクタ３１４ａは、着脱自在に接続される。これによって、第１メインライン３０１ａは、第１チューブ３１２ａと第２チューブ３１５ａとの間で分離可能である。 The first main line 301a includes, in order from the upstream side, a syringe connector 310a, a T-tube 311a, a first tube 312a, a rotating high-pressure adapter 313a, a female Luer lock connector 314a, and a second tube 315a. The syringe connector 310a is rotatably connected to the T-tube 311a via a rotary joint, and the syringe 20A is detachably connected thereto. The rotating high-pressure adapter 313a and the female Luer lock connector 314a are detachably connected. Accordingly, the first main line 301a can be separated between the first tube 312a and the second tube 315a.
　第１サブライン３０１ｂは、第１容器４０Ａと第１メインライン３０１ａとを接続する。第１サブライン３０１ｂは、第１容器４０Ａ側から順に、スパイク３１０ｂ、第３チューブ３１１ｂ、ドリップチャンバー３１２ｂ、第４チューブ３１３ｂおよび一方弁３１４ｂを有する。スパイク３１０ｂは、第１容器４０Ａと接続される。一方弁３１４ｂは、第１容器４０Ａから第１メインライン３０１ａへ向かう方向のみへの液体の流れを許容する向きで取り付けられ、第１メインライン３０１ａのＴ字管３１１ａと接続される。第１容器４０Ａは、例えばボトル状の容器であり、第１容器４０Ａから流れ出た造影剤は、ドリップチャンバー３１２ｂ内に滴下した後、第１メインライン３０１ａに供給される。 The first subline 301b connects the first container 40A and the first main line 301a. The first subline 301b includes, in order from the first container 40A side, a spike 310b, a third tube 311b, a drip chamber 312b, a fourth tube 313b, and a one-way valve 314b. Spike 310b is connected to first container 40A. The one-way valve 314b is installed in a direction that allows liquid to flow only in the direction from the first container 40A toward the first main line 301a, and is connected to the T-shaped pipe 311a of the first main line 301a. The first container 40A is, for example, a bottle-shaped container, and the contrast agent flowing out from the first container 40A is dripped into the drip chamber 312b and then supplied to the first main line 301a.
　以上のように、第１サブライン３０１ｂに一方弁３１４ｂを配置することで、第１メインライン３０１ａから第１サブライン３０１ｂへ薬液が流入することが防止される。 As described above, by arranging the one-way valve 314b in the first sub-line 301b, the chemical solution is prevented from flowing into the first sub-line 301b from the first main line 301a.
　第２メインライン３０２ａは、上流側から順に、シリンジコネクタ３２０ａ、Ｔ字管３２１ａ、第１チューブ３２２ａ、回転高圧アダプタ３２３ａ、雌ルアーロックコネクタ３２４ａおよび第２チューブ３２５ａを有する。シリンジコネクタ３２０ａは、回転式のジョイントを介してＴ字管３２１ａと回転自在に接続されており、シリンジ２０Ｂが着脱自在に接続される。回転高圧アダプタ３２３ａおよび雌ルアーロックコネクタ３２４ａは、着脱自在に接続される。これによって、第２メインライン３０２ａは、第１チューブ３２２ａと第２チューブ３２５ａとの間で分離可能である。 The second main line 302a includes, in order from the upstream side, a syringe connector 320a, a T-tube 321a, a first tube 322a, a rotating high-pressure adapter 323a, a female Luer lock connector 324a, and a second tube 325a. The syringe connector 320a is rotatably connected to the T-tube 321a via a rotary joint, and the syringe 20B is detachably connected thereto. The rotating high-pressure adapter 323a and the female Luer lock connector 324a are detachably connected. Accordingly, the second main line 302a can be separated between the first tube 322a and the second tube 325a.
　第２サブライン３０２ｂは、第２容器４０Ｂと第２メインライン３０２ａとを接続する。第２サブライン３０２ｂは、第２容器４０Ｂ側から順に、スパイク３２０ｂ、第３チューブ３２１ｂ、ドリップチャンバー３２２ｂ、第４チューブ３２３ｂおよび一方弁３２４ｂを有する。スパイク３２０ｂは、第２容器４０Ｂと接続される。一方弁３２４ｂは、第２容器４０Ｂから第２メインライン３０２ａへ向かう方向のみへの液体の流れを許容する向きで取り付けられ、第２メインライン３０２ａのＴ字管３２１ａと接続される。第２容器４０Ｂは、例えばバッグ状の容器であり、第２容器４０Ｂから流れ出た生理食塩水は、ドリップチャンバー３２２ｂ内に滴下した後、第２メインライン３０２ａに供給される。 The second subline 302b connects the second container 40B and the second main line 302a. The second subline 302b includes, in order from the second container 40B side, a spike 320b, a third tube 321b, a drip chamber 322b, a fourth tube 323b, and a one-way valve 324b. Spike 320b is connected to second container 40B. The one-way valve 324b is installed in a direction that allows liquid to flow only in the direction from the second container 40B toward the second main line 302a, and is connected to the T-shaped pipe 321a of the second main line 302a. The second container 40B is, for example, a bag-shaped container, and the physiological saline flowing out from the second container 40B is supplied to the second main line 302a after dripping into the drip chamber 322b.
　以上のように、第２サブライン３０２ｂに一方弁３２４ｂを配置することで、第２メインライン３０２ａから第２サブライン３０２ｂへ薬液が流入することが防止される。 As described above, by arranging the one-way valve 324b in the second subline 302b, the chemical solution is prevented from flowing into the second subline 302b from the second main line 302a.
　被検者ライン３０３は、上流側から順に、ミキシングデバイス３３０、第５チューブ３３１、流路開閉弁３３２、流路開閉弁３３２とチューブを介して接続された一方弁３３３、Ｔ字管３３４、第６チューブ３３５およびコネクタ３３６を有する。ミキシングデバイス３３０は、２つの流入口および１つの流出口を有し、各流入口から流入した液体を混合して流出口から流出するように構成される。ミキシングデバイス３３０の各流入口はそれぞれ第１メインライン３０１ａの第２チューブ３１５ａおよび第２メインライン３０２ａの第２チューブ３２５ａに接続される。ミキシングデバイス３３０の流出口は、第５チューブ３３１に接続される。ミキシングデバイス３３０としては、例えば、株式会社根本杏林堂製の「ＳＰＩＲＡＬ　ＦＬＯＷ」（登録商標）を用いることができる。また、ミキシングデバイス３３０の代わりにＴ字コネクタを用いることもできる。 The subject line 303 includes, in order from the upstream side, a mixing device 330, a fifth tube 331, a flow path on-off valve 332, a one-way valve 333 connected to the flow path on-off valve 332 via a tube, a T-shaped pipe 334, and a fifth tube. 6 tubes 335 and connectors 336. The mixing device 330 has two inlets and one outlet, and is configured to mix liquids flowing in from each inlet and flowing out from the outlet. Each inlet of the mixing device 330 is connected to the second tube 315a of the first main line 301a and the second tube 325a of the second main line 302a, respectively. The outlet of the mixing device 330 is connected to the fifth tube 331 . As the mixing device 330, for example, "SPIRAL FLOW" (registered trademark) manufactured by Nemoto Kyorindo Co., Ltd. can be used. Also, a T-shaped connector can be used instead of the mixing device 330.
　流路開閉弁３３２は、流路の開放および閉鎖を制御可能に構成されたユニットである。流路開閉弁３３２について詳しくは後述する。 The flow path opening/closing valve 332 is a unit configured to be able to control opening and closing of the flow path. The channel opening/closing valve 332 will be described in detail later.
　　一方弁３３３は、上流から下流へ向かう方向のみへ液体の流れを許容する向きで取り付けられる。コネクタ３３６は被検者ライン３０３の下流端に配置されており、被検者ライン３０３は、コネクタ３３６を介して、被検者に穿刺または挿入されるカテーテルなどに接続される。 The one-way valve 333 is installed in an orientation that allows liquid to flow only in the direction from upstream to downstream. The connector 336 is arranged at the downstream end of the subject line 303, and the subject line 303 is connected to a catheter or the like to be punctured or inserted into the subject via the connector 336.
　トランスデューサライン３０４は、被検者ライン３０３から分岐するように被検者ライン３０３のＴ字管３３４に接続されたラインであり、Ｔ字管３３４側から順に、１本のチューブまたは直列に接続された複数のチューブからなるチューブアセンブリ３４０、およびコネクタ３４３を有する。チューブアセンブリ３４０は、その少なくとも一部が、外側から挟み付けることによって押し潰すことができる程度の柔軟性を有する。コネクタ３４３には、被検者の血圧を検出して脈をモニタリングするために、トランスデューサ７０が接続される。トランスデューサ７０には、被検者の脈の波形を表示するディスプレイ（不図示）が接続される。 The transducer line 304 is a line connected to the T-tube 334 of the subject line 303 so as to branch from the subject line 303, and is a line connected to the T-shaped tube 334 of the subject line 303 in order from the T-shaped tube 334 side. The tube assembly 340 includes a plurality of tubes, and a connector 343. At least a portion of the tube assembly 340 is flexible enough to be crushed by being pinched from the outside. The transducer 70 is connected to the connector 343 in order to detect the subject's blood pressure and monitor the pulse. A display (not shown) that displays the pulse waveform of the subject is connected to the transducer 70.
　上述のとおり構成された薬液回路３０は、下流側の単数回使用部３００Ａと上流側の複数回使用部３００Ｂとに分けることができる。単数回使用部３００Ａとは、１回のみ使用できる、いわゆる使い捨てとされる部分である。複数回使用部３００Ｂとは、複数回繰り返し使用できる部分である。具体的には、単数回使用部３００Ａは、第１メインライン３０１ａの雌ルアーロックコネクタ３１４ａで分離される下流側の部分、第２メインライン３０２ａの雌ルアーロックコネクタ３２４ａで分離される下流側の部分、被検者ライン３０３およびトランスデューサライン３０４で構成される。複数回使用部３００Ｂは、薬液回路３０の単数回使用部３００Ａ以外の部分、すなわち、第１メインライン３０１ａの回転高圧アダプタ３１３ａで分離される上流側の部分、第１サブライン３０１ｂ、第２メインライン３０２ａの回転高圧アダプタ３２３ａで分離される上流側の部分および第２サブライン３０２ｂで構成される。 The chemical liquid circuit 30 configured as described above can be divided into a downstream single-use section 300A and an upstream multi-use section 300B. The single-use portion 300A is a so-called disposable portion that can be used only once. The multiple-use portion 300B is a portion that can be used repeatedly multiple times. Specifically, the single-use portion 300A includes a downstream portion separated by the female Luer lock connector 314a of the first main line 301a, and a downstream portion separated by the female Luer lock connector 324a of the second main line 302a. 3, a subject line 303 and a transducer line 304. The multiple use section 300B is a portion of the chemical liquid circuit 30 other than the single use section 300A, that is, the upstream portion of the first main line 301a separated by the rotating high pressure adapter 313a, the first subline 301b, and the second main line. 302a and a second subline 302b separated by a rotating high pressure adapter 323a.
　なお、薬液回路３０は、付属回路３５０をさらに有することができる。付属回路３５０は、一方弁付きの雌ルアーロックコネクタ３５１と、第１０チューブ３５２と、第１０チューブ３５２を介して雌ルアーロックコネクタ３５１と接続された雄ルアーロックコネクタ３５３とを有する。雌ルアーロックコネクタ３５１の一方弁は、雌ルアーロックコネクタ３５１から雄ルアーロックコネクタ３５３へ向かう方向のみへの液体の流れを許容する。複数回使用部３００Ｂは、シリンジ２０Ａ、２０Ｂおよび薬液容器４０Ａ、４０Ｂと接続された後、エア抜きが行われる。付属回路３５０は、エア抜きが終了するまで、雌ルアーロックコネクタ３５１が、第１メインライン３０１ａの回転高圧アダプタ３１３ａおよび第２メインライン３０２ａの回転高圧アダプタ３２３ａそれぞれに１つずつ接続されている。 Note that the chemical liquid circuit 30 can further include an auxiliary circuit 350. The auxiliary circuit 350 includes a female Luer lock connector 351 with a one-way valve, a tenth tube 352, and a male Luer lock connector 353 connected to the female Luer lock connector 351 via the tenth tube 352. The one-way valve of the female Luer lock connector 351 allows liquid to flow only in the direction from the female Luer lock connector 351 to the male Luer lock connector 353. After the multi-use section 300B is connected to the syringes 20A, 20B and the drug solution containers 40A, 40B, air is removed. In the attached circuit 350, one female Luer lock connector 351 is connected to each of the rotary high pressure adapter 313a of the first main line 301a and the rotary high pressure adapter 323a of the second main line 302a until air bleeding is completed.
　エア抜きの終了後、第１メインライン３０１ａおよび第２メインライン３０２ａから付属回路３５０が取り外されて、各回転高圧コネクタ３１３ａ、３２３ａにはそれぞれ単数回使用部３００Ａの雌ルアーロックコネクタ３１４ａ、３２４ａが接続される。 After air bleeding is completed, the attached circuit 350 is removed from the first main line 301a and the second main line 302a, and the female Luer lock connectors 314a, 324a of the single-use portion 300A are connected to the rotating high voltage connectors 313a, 323a, respectively. Connected.
　以下、薬液回路３０の主要な構成についてより詳細に説明する。 Hereinafter, the main configuration of the chemical liquid circuit 30 will be explained in more detail.
　（Ｂ－ａ）流路開閉弁
　図４に示すように、流路開閉弁３３２は、ハウジング５０１と、開位置および閉位置を取り得るように矢印Ｓ方向にスライド可能にハウジング５０１内に挿入されたピストン５０２と、を有する。以下、図４に示す流路開閉弁３３２について、図５、図５Ａ、図６、図６Ａ、図６Ｂも参照しつつ説明する。 (B-a) Channel opening/closing valve As shown in FIG. 4, the channel opening/closing valve 332 is slidably inserted into the housing 501 in the direction of arrow S so that it can take an open position and a closed position. and a piston 502. The flow path opening/closing valve 332 shown in FIG. 4 will be described below with reference to FIGS. 5, 5A, 6, 6A, and 6B.
　ハウジング５０１は、例えば、樹脂を射出成型することによって成型することができ、ピストン５０２をスライド自在に挿入するシリンダ部５０１ｃを有する。シリンダ部５０１ｃは、ハウジング５０１の軸方向に沿って形成された貫通孔によって構成されている。また、ハウジング５０１には、シリンダ部５０１ｃに隣接してシリンダ部５０１ｃの軸方向に直交する方向にハウジング５０１の外壁から延びる導管部５０１ａ、５０１ｂが設けられている。一方の導管部５０１ａは、被検者ライン３０３の第５チューブ３３１（図２参照）に接続される。他方の導管部５０１ｂは、チューブを介して被検者ライン３０３の一方弁３３３（図２参照）に接続される。したがって、図示した形態では、導管部５０１ａが流入路となり、導管部５０１ｂが排出路となる。 The housing 501 can be molded, for example, by injection molding of resin, and has a cylinder portion 501c into which the piston 502 is slidably inserted. The cylinder portion 501c is constituted by a through hole formed along the axial direction of the housing 501. Further, the housing 501 is provided with conduit portions 501a and 501b that are adjacent to the cylinder portion 501c and extend from the outer wall of the housing 501 in a direction perpendicular to the axial direction of the cylinder portion 501c. One conduit section 501a is connected to the fifth tube 331 (see FIG. 2) of the subject line 303. The other conduit section 501b is connected to the one-way valve 333 (see FIG. 2) of the subject line 303 via a tube. Therefore, in the illustrated embodiment, the conduit portion 501a serves as the inflow path, and the conduit portion 501b serves as the discharge path.
　さらに、ハウジング５０１には、一方の導管部５０１ａとシリンダ部５０１ｃとを連通する連通流路５０１ｅ、および他方の導管部５０１ｂとシリンダ部５０１ｃとを連通する連通流路５０１ｇが形成される。これら導管部５０１ａ、５０１ｂ、連通流路５０１ｅ、５０１ｇは、直線上に整列して配置される。 Further, the housing 501 is formed with a communication channel 501e that communicates between one conduit section 501a and the cylinder section 501c, and a communication channel 501g that communicates between the other conduit section 501b and the cylinder section 501c. These conduit portions 501a, 501b and communication channels 501e, 501g are arranged in alignment on a straight line.
　ピストン５０２は、例えば、樹脂を射出成型することによって成型された柱状の部材であり、その一端に、半径方向外側に広がるフランジ状のヘッド５０２ａを有する。ピストン５０２の長手方向中間部には、流路５０２ｂが、ピストン５０２の長手方向に直交する方向にピストン５０２を横断して形成されている。ピストン５０２の外周面には、ピストン５０２の長手方向において流路５０２ｂの両側にそれぞれＯリングなどの封止リング５０６が装着されている。 The piston 502 is, for example, a columnar member molded by injection molding of resin, and has a flange-shaped head 502a that extends radially outward at one end thereof. A flow path 502b is formed in a longitudinally intermediate portion of the piston 502 so as to cross the piston 502 in a direction perpendicular to the longitudinal direction of the piston 502. Sealing rings 506 such as O-rings are attached to the outer peripheral surface of the piston 502 on both sides of the flow path 502b in the longitudinal direction of the piston 502, respectively.
　流路開閉弁３３２は、ハウジング５０１に対するピストン５０２の移動範囲を制限するストッパ構造５０３をさらに有する。ストッパ構造５０３は、図７Ｃに示すように、ハウジング５０１に形成された凸部５０３ａと、ピストン５０２に形成された凹部５０３ｂとを有する。凹部５０３ｂは、ピストン５０２のスライド方向に延びて凸部５０３ａを受け入れる。また、凹部５０３ｂは、ピストン５０２が開位置に位置するときに凸部５０３ａが当接する第１端部５０３ｃと、ピストン５０２が閉位置に位置するときに凸部５０３ａが当接する第２端部５０３ｄとを有するように、ピストン５０２のスライド方向での長さが定められている。 The flow path opening/closing valve 332 further includes a stopper structure 503 that limits the movement range of the piston 502 with respect to the housing 501. The stopper structure 503 has a protrusion 503a formed in the housing 501 and a recess 503b formed in the piston 502, as shown in FIG. 7C. The recess 503b extends in the sliding direction of the piston 502 and receives the protrusion 503a. The recessed portion 503b also has a first end 503c, which the convex portion 503a abuts when the piston 502 is in the open position, and a second end 503d, which the convex portion 503a abuts when the piston 502 is in the closed position. The length of the piston 502 in the sliding direction is determined so as to have the following.
　凸部５０３ａは、ハウジング５０１の一部分として形成され、かつ、凹部５０３ｂはピストン５０２の一部分として形成されることができる。これにより、ハウジング５０１およびピストン５０２のみで、他の部品を用いることなくストッパ構造５０３を構成し、より少ない部品点数で流路開閉弁３３２を構成することができる。 The protrusion 503a can be formed as a part of the housing 501, and the recess 503b can be formed as a part of the piston 502. Thereby, the stopper structure 503 can be configured only with the housing 501 and the piston 502 without using other parts, and the flow path opening/closing valve 332 can be configured with a smaller number of parts.
　本形態では、２つの凸部５０３ａがハウジング５０１の外周面にハウジング５０１の周方向に等角度間隔で形成されている。それに対応して、ピストン５０２にも２つの凹部５０３ｂがピストン５０２の周方向に等角度間隔で形成されている。凸部５０３ａの数は、１つでもよいし、３つ以上でもよい。凹部５０３ｂの数についても、凸部５０３ａの数と同様である。 In this embodiment, two convex portions 503a are formed on the outer peripheral surface of the housing 501 at equal angular intervals in the circumferential direction of the housing 501. Correspondingly, two recesses 503b are also formed in the piston 502 at equal angular intervals in the circumferential direction of the piston 502. The number of protrusions 503a may be one, or three or more. The number of concave portions 503b is also the same as the number of convex portions 503a.
　凸部５０３ａがハウジング５０１の外周面に形成される場合、図に示すように、凹部５０３ｂを、ピストン５０２の一方の端部（図示した形態では、凹部５０３ｂはピストン５０２のヘッド５０２ａと反対側の端部に形成されているが、ヘッド５０２ａ側の端部に形成されてもよい。）からハウジング５０１の周壁を越えて延び、ハウジング５０１の外周面に回り込むようにフック状に形成することが好ましい。 When the convex portion 503a is formed on the outer circumferential surface of the housing 501, the concave portion 503b is formed at one end of the piston 502 (in the illustrated form, the concave portion 503b is formed on the side opposite to the head 502a of the piston 502, as shown in the figure). Although it is formed at the end, it may be formed at the end on the head 502a side.) It is preferable to form it in a hook shape so as to extend beyond the peripheral wall of the housing 501 and wrap around the outer peripheral surface of the housing 501. .
　これによって、凸部５０３ａが凹部５０３ｂに受け入れられるように構成することができる。また、凹部５０３ｂをフック状に形成することで、ハウジング５０１およびピストン５０２以外の他の部品を用いることなく、ハウジング５０１とピストン５０２とをスナップフィット式の接続で連結することができる。また、図５に示すようにハウジング５０１の周壁に切込み５０３ｅを形成し、この切込み５０３ｅを通って凹部５０３ｂがハウジング５０１の外周面に回り込むようにすることで、流路開閉弁３３２をコンパクトに構成することができる。 With this, it is possible to configure the convex portion 503a to be received in the concave portion 503b. Further, by forming the recess 503b in a hook shape, the housing 501 and the piston 502 can be connected by a snap-fit type connection without using any other parts other than the housing 501 and the piston 502. Furthermore, as shown in FIG. 5, a notch 503e is formed in the peripheral wall of the housing 501, and the recess 503b wraps around the outer peripheral surface of the housing 501 through the notch 503e, thereby making the flow path opening/closing valve 332 compact. can do.
　本形態では、ハウジング５０１に凸部５０１ａが形成され、ピストン５０２に凹部５０３ｂが形成されているが、その逆であってもよい。つまり、ハウジング５０１に凹部が形成され、ピストン５０２に凸部が形成されてもよい。この場合、凹部をハウジング５０１の内周面に形成し、凸部をピストン５０２の外周面に形成することができる。 In this embodiment, the protrusion 501a is formed on the housing 501, and the recess 503b is formed on the piston 502, but the opposite may be used. That is, the housing 501 may have a recess and the piston 502 may have a protrusion. In this case, a concave portion can be formed on the inner circumferential surface of the housing 501 and a convex portion can be formed on the outer circumferential surface of the piston 502.
　流路開閉弁３３２の動作について、図４に示す流路開閉弁３３２の７Ａ－７Ａ線断面図である 図７Ａ、および図４に示す流路開閉弁３３２の７Ｂ－７Ｂ線断面図である図７Ｂを参照して以下に説明する。 Regarding the operation of the flow path on-off valve 332, FIG. 7A is a sectional view taken along the line 7A-7A of the flow path on-off valve 332 shown in FIG. 4, and FIG. This will be explained below with reference to 7B.
　開位置（図示した形態では、ピストン５０２がハウジング５０１内に押し込まれた状態）では、ピストン５０２の流路５０２ｂは、ハウジング５０１の連通流路５０１ｅ、５０１ｇと同一直線上に位置し、導管部５０１ａ、５０１ｂは、流路５０２ｂを介して連通している。また、開位置においては、ピストン５０２の凹部５０３ｂの第１端部５０３ｃが、ハウジング５０１の凸部５０３ａに当接し、ピストン５０２がこれ以上ハウジング５０１内に押し込まれないよう、ピストン５０２の押し込み方向への移動量が制限されている。 In the open position (in the illustrated embodiment, the piston 502 is pushed into the housing 501), the flow path 502b of the piston 502 is located on the same straight line as the communication flow paths 501e and 501g of the housing 501, and the conduit portion 501a , 501b are in communication via a flow path 502b. In addition, in the open position, the first end 503c of the recess 503b of the piston 502 comes into contact with the protrusion 503a of the housing 501, and the piston 502 is moved in the pushing direction so that the piston 502 is not pushed further into the housing 501. The amount of movement is limited.
　開位置においてピストン５０２をハウジング５０１から引き出すと、ピストン５０２の移動に伴って流路５０２ｂが移動する。ピストン５０２が閉位置から距離Ｌだけ引き出されて閉位置に位置すると、連通流路５０１ｅ、５０１ｇがピストン５０２によって完全に塞がれ、導管部５０１ａ、５０１ｂ間での流体の流れが遮断される。 When the piston 502 is pulled out from the housing 501 in the open position, the flow path 502b moves as the piston 502 moves. When the piston 502 is pulled out by a distance L from the closed position and located at the closed position, the communication channels 501e and 501g are completely blocked by the piston 502, and the flow of fluid between the conduit portions 501a and 501b is blocked.
　また、開位置から閉位置へのピストン５０２の移動に伴って、ピストン５０２の凹部５０３ｂもピストン５０２の移動方向に沿って移動し、閉位置では凸部５０３ａは凹部５０３ｂの第２端部５０３ｄに当接する。これによって、ピストン５０２がこれ以上ハウジング５０１から引き出されないよう、ピストン５０２の引き出し方向への移動量が制限されている。 Further, as the piston 502 moves from the open position to the closed position, the recess 503b of the piston 502 also moves along the moving direction of the piston 502, and in the closed position, the convex part 503a is connected to the second end 503d of the recess 503b. come into contact with As a result, the amount of movement of the piston 502 in the withdrawal direction is limited so that the piston 502 is not pulled out any further from the housing 501.
　ハウジング５０１に対するピストン５０２の移動範囲を制限するストッパ構造５０３を、ハウジング５０１の一部およびピストン５０２の一部で構成することで、流路開閉弁３３２を、少なくともハウジング５０１、ピストン５０２、および２つの封止リング５０６という４つの部品で構成することができる。また、ストッパ構造５０３は、凸部５０３ａと凹部５０３ｂとの係合を利用した構造であるので、ピストン５０２をハウジング５０１に挿入し、さらに凸部５０３ａと凹部５０３ｂとをスナップフィット式に係合させることで、接着剤を用いることなく流路開閉弁３３２を組み立てることができる。よって、本形態の流路開閉弁３３２は、最小限の部品点数で構成できるという観点、および／または組み立て工数を削減できるという観点から、大幅なコストダウンが可能となる。 By configuring the stopper structure 503 that limits the movement range of the piston 502 with respect to the housing 501 from a part of the housing 501 and a part of the piston 502, the flow path opening/closing valve 332 can be operated by at least the housing 501, the piston 502, and the two It can be constructed of four parts: a sealing ring 506; Furthermore, since the stopper structure 503 is a structure that utilizes the engagement between the convex portion 503a and the concave portion 503b, the piston 502 is inserted into the housing 501, and the convex portion 503a and the concave portion 503b are further engaged in a snap-fit manner. By doing so, the flow path opening/closing valve 332 can be assembled without using adhesive. Therefore, the flow path opening/closing valve 332 of this embodiment can be configured with a minimum number of parts, and/or the number of assembly steps can be reduced, allowing for significant cost reduction.
　閉位置において連通流路５０１ｅ、５０１ｇと流路５０２ｂが確実に遮断されるようにするためには、ハウジング５０１の内周面とピストン５０２の外周面とが少なくとも閉位置において接触していることが望ましい。そのためには、例えば、ピストン５０２の外周面にパッキンを追加することができる。あるいは、ピストン５０２とハウジング５０１とを弾性率の異なる材料で構成することもできる。この場合、パッキンは不要である。ハウジング５０１およびピストン５０２を弾性率の異なる材料で構成する場合、例えば、ハウジングをポリカーボネート（ＰＣ）で構成し、ピストンを高密度ポリエチレン（ＨＤＰＥ）で構成することができる。 In order to ensure that the communication channels 501e, 501g and the channel 502b are blocked in the closed position, the inner circumferential surface of the housing 501 and the outer circumferential surface of the piston 502 must be in contact at least in the closed position. desirable. For this purpose, for example, packing can be added to the outer peripheral surface of the piston 502. Alternatively, the piston 502 and the housing 501 may be made of materials having different moduli of elasticity. In this case, packing is not necessary. When the housing 501 and the piston 502 are made of materials with different moduli of elasticity, for example, the housing can be made of polycarbonate (PC) and the piston can be made of high-density polyethylene (HDPE).
　ハウジング５０１に対するピストンの押し込み動作および引き出し動作は、ヘッド５０２ａを利用して行うことができる。具体的には、ハウジング５０１を固定した状態で、ヘッド５０２ａに係合してピストン５０２の移動方向に往復移動するよう動作される係合部材をヘッド５０２ａに係合させて、ピストン５０１を開位置と閉位置との間で動作させることができる。係合部材がより容易にヘッド５０２ａに係合でき、その状態でピストン５０２を開位置と閉位置との間で移動できるようにするために、開位置と閉位置との間でのピストン５０２の移動範囲においてピストン５０２の移動方向一端部がハウジング５０１から突出するようにし、その突出した部分にヘッド５０２ａを構成することが好ましい。あるいは、開位置と閉位置との間でのピストン５０２の移動範囲においてピストン５０２の移動方向両端部がハウジング５０１から突出するようにしたり、開位置においてはピストン５０２の一方の端部のみが突出し、閉位置においてはピストン５０２の他方の端部のみが突出するようにしたりすることもできる。この場合、ピストン５０２の両側からそれぞれピストン５０２を押し込むことによって、開位置と閉位置との間でピストン５０２を移動させることができるので、ヘッド５０２ａのような、係合部材が係合するための構造は不要である。ピストン５０２の押し込みには、ロッド状の押し込み部材を用いることができる。押し込み部材として、シリンダ部５０１ｃの直径以下の直径を有する押し込み部材を用いれば、ピストン５０２の長さは、開位置および閉位置の両方でピストン５０２がハウジング５０１から突出しない長さとすることもできる。 The pushing and pulling operations of the piston into and out of the housing 501 can be performed using the head 502a. Specifically, with the housing 501 fixed, an engagement member that engages with the head 502a and is operated to reciprocate in the moving direction of the piston 502 is engaged with the head 502a, and the piston 501 is moved to the open position. and the closed position. The movement of the piston 502 between the open and closed positions is such that the engagement member can more easily engage the head 502a and move the piston 502 between the open and closed positions. It is preferable that one end of the piston 502 in the moving direction protrudes from the housing 501 in the moving range, and the head 502a is formed in the protruding portion. Alternatively, in the movement range of the piston 502 between the open position and the closed position, both ends of the piston 502 in the moving direction protrude from the housing 501, or only one end of the piston 502 protrudes in the open position, It is also possible that only the other end of the piston 502 protrudes in the closed position. In this case, the piston 502 can be moved between the open position and the closed position by pushing the piston 502 from both sides of the piston 502, so that the engaging member such as the head 502a can be engaged. No structure is required. A rod-shaped pushing member can be used to push the piston 502. If a pushing member having a diameter equal to or smaller than the diameter of the cylinder portion 501c is used as the pushing member, the length of the piston 502 can be set to such a length that the piston 502 does not protrude from the housing 501 in both the open position and the closed position.
　以上説明したように、本形態の流路開閉弁３３２は、ハウジング５０１，ハウジング５０１にスライド自在に挿入されたピストン５０２、およびピストン５０２のスライド量を制限するストッパ構造５０３を有し、このストッパ構造５０３をハウジング５０１およびピストン５０２で構成するようにしたことで、高圧下での動作においても薬液の漏れが生じない安定した動作を達成することができる。 As described above, the flow path opening/closing valve 332 of the present embodiment includes a housing 501, a piston 502 slidably inserted into the housing 501, and a stopper structure 503 that limits the sliding amount of the piston 502. By configuring 503 by housing 501 and piston 502, stable operation without leakage of chemical liquid can be achieved even when operating under high pressure.
　なお、流路開閉弁３３２としては、上述した構成のものに限らず、他の構成であってもよい。例えば、流路開閉弁３３２の代わりに、国際公開第２０１８／１８１２７０号に記載された開閉ユニットを用いることもできるし、後述する押しつぶし機構を用いることもできる。 Note that the flow path opening/closing valve 332 is not limited to the configuration described above, and may have other configurations. For example, instead of the channel opening/closing valve 332, the opening/closing unit described in International Publication No. 2018/181270 can be used, or the crushing mechanism described below can also be used.
　（Ｂ－ｂ）一方弁
　上述したとおり、第１サブライン３０１ｂ、第２サブライン３０２ｂおよび被検者ライン３０３は、それぞれ一方弁３１４ｂ、３２４ｂおよび３３３を有している。以下、薬液回路のような高圧下での使用に適した一方弁のいくつかの形態を説明する。 (Bb) One-way valve As described above, the first subline 301b, the second subline 302b, and the subject line 303 have one- way valves 314b, 324b, and 333, respectively. Hereinafter, several forms of one-way valves suitable for use under high pressure such as in chemical liquid circuits will be described.
　［一方弁の形態１］
　図８Ａを参照すると、形態１による一方弁６１０の斜視図が示される。また、図８Ｂは、図８Ａに示した一方弁６１０の分解斜視図を示し、図８Ｃは、一方弁６１０の、図８Ａの８Ｃ－８Ｃ線で切断した断面図を示す。 [One-way valve form 1]
Referring to FIG. 8A, a perspective view of a one-way valve 610 according to Form 1 is shown. 8B shows an exploded perspective view of the one-way valve 610 shown in FIG. 8A, and FIG. 8C shows a cross-sectional view of the one-way valve 610 taken along line 8C-8C in FIG. 8A.
　形態１による一方弁６１０は、第１ケース６１１、第２ケース６１２および弁体６１３を有し、矢印８Ａ方向のみへの薬液の流れを許容するように構成される。弁体６１３は、球状の部材であり、第１ケース６１１と第２ケース６１２とが嵌め合い式に接合されることによって形成される弁室６１０ａ内に移動自在に配置される。 The one-way valve 610 according to Form 1 has a first case 611, a second case 612, and a valve body 613, and is configured to allow the flow of the chemical liquid only in the direction of arrow 8A. The valve body 613 is a spherical member, and is movably arranged in a valve chamber 610a formed by fittingly joining the first case 611 and the second case 612.
　第１ケース６１１は、図８Ｂ、図８Ｃ、および図８Ｂとは別角度からの斜視図である図８Ｄにも示すように、受入れ凹部６１１ａ、下流側流路６１１ｂおよび弁体位置規制突起６１１ｃを有する。受入れ凹部６１１ａは、全体として凹球面状の表面を有し、球状の弁体６１３を受け入れる。下流側流路６１１ｂは、受入れ凹部６１１ａと連通して、第１ケース６１１の第２ケース６１２との接合部と反対側の端部に開口する。弁体位置規制突起６１１ｃは、一方弁６１０内での薬液の流れ方向（矢印８Ａ方向）下流側に移動した弁体６１３が当接することによって、弁体６１３が下流側流路６１１ｂを塞がないように弁体６１３の位置を規制する。 As shown in FIGS. 8B, 8C, and FIG. 8D, which is a perspective view taken from a different angle from FIG. have The receiving recess 611a has a concave spherical surface as a whole and receives the spherical valve body 613. The downstream flow path 611b communicates with the receiving recess 611a and opens at the end of the first case 611 opposite to the joint with the second case 612. The valve body position regulating protrusion 611c is brought into contact with the valve body 613 that has moved downstream in the flow direction of the chemical solution in the one-way valve 610 (arrow 8A direction), so that the valve body 613 does not block the downstream flow path 611b. The position of the valve body 613 is regulated as follows.
　一方弁６１０内での薬液の流路をより良好に確保するために、第１ケース６１１の受入れ凹部６１１ａの表面に、溝６１１ｄおよび／または凸部６１１ｅが形成されていてもよい。溝６１１ｄは、一方弁６１０内での薬液の流れ方向に沿って、受入れ凹部６１１ａの全体に渡って形成することが好ましい。凸部６１１ｅは、受入れ凹部６１１ａの表面に対して突出していれば、一方弁６１０内での薬液の流れ方向において、受入れ凹部６１１ａの全体に渡って形成されていてもよいし、一部のみに形成されていてもよい。溝６１１ｄの数および凸部６１１ｅの数は、１つでもよいし２つ以上でもよい。溝６１１ｄの数および凸部６１１ｅの数は同じであってもよいし異なっていてもよい。複数の溝６１１ｄを形成する場合、複数の溝６１１ｄは一方弁６１０の周方向において等角度間隔で配置することが好ましく、これによって、弁室６１０ａ内での薬液の移動に偏りが生じず、弁室６１０ａ内で弁体６１３をスムーズに移動させることができる。複数の凸部６１１ｅを形成する場合も、複数の溝６１１ｄを形成する場合と同様である。 In order to better ensure a flow path for the chemical liquid within the one-way valve 610, a groove 611d and/or a protrusion 611e may be formed on the surface of the receiving recess 611a of the first case 611. The groove 611d is preferably formed along the flow direction of the chemical solution within the one-way valve 610 over the entire receiving recess 611a. As long as the convex portion 611e protrudes from the surface of the receiving recess 611a, it may be formed over the entire receiving recess 611a in the flow direction of the chemical solution in the one-way valve 610, or may be formed only in a part of the receiving recess 611a. may be formed. The number of grooves 611d and the number of protrusions 611e may be one or two or more. The number of grooves 611d and the number of protrusions 611e may be the same or different. When forming the plurality of grooves 611d, it is preferable that the plurality of grooves 611d are arranged at equal angular intervals in the circumferential direction of the one-way valve 610. This prevents uneven movement of the chemical liquid within the valve chamber 610a and prevents the valve from moving unbalanced. The valve body 613 can be moved smoothly within the chamber 610a. The case where a plurality of convex portions 611e are formed is similar to the case where a plurality of grooves 611d are formed.
　第２ケース６１２は、図８Ｃ、および図８Ａの８Ｃ－８Ｃ線で破断した斜視図である図８Ｅに示すように、弁座６１２ａおよび上流側流路６１２ｂを有する。弁座６１２ａは、凹球面状の表面を有する。上流側流路６１２ｂは、弁座６１２ａと連通して、第２ケース６１２の第１ケース６１１との接合部と反対側の端部に開口する。 The second case 612 has a valve seat 612a and an upstream flow path 612b, as shown in FIG. 8C and FIG. 8E, which is a perspective view taken along line 8C-8C in FIG. 8A. The valve seat 612a has a concave spherical surface. The upstream flow path 612b communicates with the valve seat 612a and opens at the end of the second case 612 opposite to the joint with the first case 611.
　上述の構成において、弁室６１０ａ内が陰圧になる等、一方弁６１０内での液体の流れ方向上流側の圧力が下流側の圧力よりも高くなると、弁体６１３が弁室６１０ａ内で第２ケース６１２側から第１ケース６１１側へ移動し、これによって、流体は一方弁６１０内を流れることができる。すなわち、一方弁６１０が開く。逆に、弁室６１０ａ内が陽圧になる等、一方弁６１０内での液体の流れ方向上流側の圧力が下流側の圧力よりも低くなると、弁体６１３が弁室６１０ａ内で第１ケース６１１側から第２ケース６１２側へ移動し、これによって、弁室６１０ａが塞がれる。すなわち、一方弁６１０が閉じる。 In the above-described configuration, when the pressure on the upstream side in the flow direction of liquid in the one-way valve 610 becomes higher than the pressure on the downstream side, such as when the inside of the valve chamber 610a becomes negative pressure, the valve body 613 moves inside the valve chamber 610a. The fluid moves from the second case 612 side to the first case 611 side, thereby allowing fluid to flow inside the one-way valve 610. That is, one-way valve 610 opens. Conversely, when the pressure on the upstream side in the flow direction of liquid in the one-way valve 610 becomes lower than the pressure on the downstream side, such as when the inside of the valve chamber 610a becomes positive pressure, the valve body 613 moves to the first case inside the valve chamber 610a. The valve chamber 610a is moved from the 611 side to the second case 612 side, thereby closing the valve chamber 610a. That is, one-way valve 610 is closed.
　ここで、前述したとおり第１ケース６１１の受入れ凹部６１１ａは全体として凹球面状の表面を有し、第２ケース６１２の弁座６１２ａは、凹球面状の表面を有する。また、弁体６１３は球状の部材である。よって、一方弁６１０が開いた状態において、受入れ凹部６１１ａと弁座６１２ａとで形成される弁室６１０ａ内を流体が流れるとき、弁室６１０ａの内部で乱流が生じにくく、気泡の発生が抑制され得る構造となっている。これにより、例えば、一方弁６１０の上流側に薬液ボトル等の薬液容器を接続するとともに下流側に空のシリンジを接続し、薬液容器からシリンジ内に薬液を吸引した場合に、シリンジ内への気泡の流入を抑制することができる。 Here, as described above, the receiving recess 611a of the first case 611 has a concave spherical surface as a whole, and the valve seat 612a of the second case 612 has a concave spherical surface. Further, the valve body 613 is a spherical member. Therefore, when the one-way valve 610 is open and fluid flows inside the valve chamber 610a formed by the receiving recess 611a and the valve seat 612a, turbulence is less likely to occur inside the valve chamber 610a, and the generation of air bubbles is suppressed. It has a structure that can be used. This prevents air bubbles from entering the syringe when, for example, a drug container such as a drug bottle is connected to the upstream side of the one-way valve 610 and an empty syringe is connected to the downstream side, and the drug solution is sucked from the drug container into the syringe. It is possible to suppress the influx of
　また、一方弁６１０が開いた状態から閉じた状態へ動作する際に、上流側と下流側との間での流体の圧力の変化に応じて弁体６１３がスムーズに移動するようにするために、弁体６１３は、一方弁６１０を流れる流体の比重より小さい比重を有する材料で構成することが好ましい。例えば、この一方弁６１０を造影剤や生理食塩水用の薬液回路に用いる場合、弁体６１３はポリプロピレン（ＰＰ）で構成することができる。これにより、流体の逆流を防止することができる。 Further, when the one-way valve 610 moves from the open state to the closed state, the valve body 613 is made to move smoothly according to the change in fluid pressure between the upstream side and the downstream side. The valve body 613 is preferably made of a material having a specific gravity smaller than the specific gravity of the fluid flowing through the one-way valve 610. For example, when this one-way valve 610 is used in a chemical liquid circuit for contrast medium or physiological saline, the valve body 613 can be made of polypropylene (PP). Thereby, backflow of fluid can be prevented.
　なお、第２ケース６１２の上流側端部には、ルアーロック式の連結構造が形成されている。第２ケース６１２と接続されるチューブにもこれと接続されるルアーロック式のコネクタが取り付けられており、ユーザが第２ケース６１２にチューブを着脱できるように構成されている。 Note that a Luer lock type connection structure is formed at the upstream end of the second case 612. A luer lock type connector is also attached to the tube connected to the second case 612, so that the user can attach and detach the tube to the second case 612.
　第１ケース６１１と第２ケース６１２との接合方法は特に限定されず、例えば、接着剤を用いた接着、および熱溶着や超音波溶着などの溶着を挙げることができる。第１ケース６１１と第２ケース６１２とを接着剤で接合する場合、例えば、第１ケース６１１および第２ケース６１２のいずれか一方に、両者の接合部への接着剤の注入口およびリザーバを兼ねる凹部を形成することができる。一方弁６１０の形態１では、第１ケース６１１と第２ケース６１２との接合部は、互いの向き合う端部側において、第１ケース６１１の外周面と第２ケース６１２の内周面とが接合されるように構成される。そこで、形態１では、図８Ｅに示すように第２ケース６１２に凹部６１２ｄを形成している。 The method of joining the first case 611 and the second case 612 is not particularly limited, and examples thereof include bonding using an adhesive and welding such as thermal welding and ultrasonic welding. When joining the first case 611 and the second case 612 with adhesive, for example, one of the first case 611 and the second case 612 may serve as an injection port and a reservoir for the adhesive to the joint between the two. A recess can be formed. In the first embodiment of the one-way valve 610, the joint between the first case 611 and the second case 612 is such that the outer circumferential surface of the first case 611 and the inner circumferential surface of the second case 612 are joined at their opposing end sides. configured to be used. Therefore, in the first embodiment, a recess 612d is formed in the second case 612, as shown in FIG. 8E.
　第１ケース６１１と第２ケース６１２との接合に際しては、まず、第１ケース６１１と第２ケース６１２との間に弁体６１３を配置した状態で第２ケース６１２に第１ケース６１１を嵌め合わせる。その後、第２ケース６１２の凹部６１２ｄに接着剤を流し込む。すると、流し込んだ接着剤は、毛管現象によって第１ケース６１１と第２ケース６１２との接合面に浸入する。さらに、第１ケース６１１を一方弁６１０の周方向に回転させると、浸入した接着剤が周方向に広がり、最終的に接着剤は全周にわたって第１ケース６１１と第２ケース６１２との接合面に塗布される。この状態で接着剤を乾燥させることで、第１ケース６１１と第２ケース６１２とが接合される。これにより、簡単かつ確実に第１ケース６１１と第２ケース６１２とを接合することができる。 When joining the first case 611 and the second case 612, first, the first case 611 is fitted into the second case 612 with the valve body 613 disposed between the first case 611 and the second case 612. . After that, adhesive is poured into the recess 612d of the second case 612. Then, the poured adhesive enters the joint surface between the first case 611 and the second case 612 due to capillary action. Furthermore, when the first case 611 is rotated in the circumferential direction of the one-way valve 610, the infiltrated adhesive spreads in the circumferential direction, and finally the adhesive spreads over the entire circumference of the joint surface between the first case 611 and the second case 612. is applied to. By drying the adhesive in this state, the first case 611 and the second case 612 are joined. Thereby, the first case 611 and the second case 612 can be easily and reliably joined.
　以上説明したように、本形態によれば、第１ケース６１１と第２ケース６１２とを嵌め込み式に接合することによって両者のより広い接合面積を確保し、かつ、弁体６１３を球状の部材で構成することで、高圧下での動作においても薬液の漏れが生じない安定した動作を達成することができる。 As explained above, according to the present embodiment, a wider joint area is secured between the first case 611 and the second case 612 by fitting them together, and the valve body 613 is made of a spherical member. With this configuration, stable operation without leakage of chemical liquid can be achieved even when operating under high pressure.
　なお、形態１では、第２ケース６１２にチューブを着脱自在に装着できるようにするため、第２ケース６１２の上流側端部にルアーロック式の連結構造が形成されているが、この連結構造は必須ではなく、第２ケース６１２とチューブとが接着されていてもよい。。 In addition, in the first embodiment, a Luer lock type connection structure is formed at the upstream end of the second case 612 in order to allow the tube to be detachably attached to the second case 612. This is not essential, and the second case 612 and the tube may be bonded together. .
　［一方弁の形態２］
　図９Ａ、９Ｂに一方弁の形態２の流体の流れ方向に沿った断面図を示す。図９Ａおよび図９Ｂは、それぞれ一方弁が閉じた状態および開いた状態を示している。形態２の基本的な構成は形態１と同じであり、第１ケース６１１、第２ケース６１２および弁体６１３を有する。ただし、形態２では弁体６１３のサイズおよび材料が形態１と異なる。以下、形態１と同じであってよい構成の説明は省略し、主に弁体６１３について説明する。 [One-way valve form 2]
FIGS. 9A and 9B show cross-sectional views along the fluid flow direction of the second one-way valve. 9A and 9B show the one-way valve in a closed and open state, respectively. The basic configuration of the second embodiment is the same as the first embodiment, and includes a first case 611, a second case 612, and a valve body 613. However, in the second embodiment, the size and material of the valve body 613 are different from those in the first embodiment. Hereinafter, a description of the configuration that may be the same as that of the first embodiment will be omitted, and the valve body 613 will be mainly described.
　形態２では、弁体６１３は、球状の部分である本体６１３ａと、本体６１３ａから突出した部分である突出部６１３ｂと、を有する。突出部６１３ｂは、弁室と上流側流路６１２ｂとを連通する連通孔内に位置し、かつ、弁室と上流側流路６１２ｂとの間での流体の流れを許容するサイズおよび形状とされる。 In form 2, the valve body 613 has a main body 613a that is a spherical part and a protrusion 613b that is a part that projects from the main body 613a. The protrusion 613b is located in a communication hole that communicates the valve chamber and the upstream flow path 612b, and has a size and shape that allows fluid to flow between the valve chamber and the upstream flow path 612b. Ru.
　このような突出部６１３ｂは、一方弁６１０の組み立てにおいて第１ケース６１１と第２ケース６１２とを接合するとき、弁体６１３を定位置に保持するのに利用することができる。例えば、弁体６１３を弁座６１２ａに当接させたときに突状部６１３ｂが第２の連通孔内に位置することができるような向きで第２ケース６１２に対して弁体６１３を配置し、この状態で、細長い棒状の弁体固定治具（不図示）を第２ケース６１２の弁座６１２ａとは反対側から上流側流路６１２ｂ内に挿入する。弁体固定治具の先端は突状部６１３ｂを固定できる構造を有しており、この構造を利用して、挿入した弁体固定治具に弁体６１３を固定する。これにより弁体６１３が第２ケース６１２に対して定位置に保持されるので、この状態で第２ケース６１２と第１ケース６１１を接合することにより、より容易に弁体６１０を組み立てることができる。弁体６１０の組み立て後、弁体固定治具は弁体６１３から取り外される。 Such a protrusion 613b can be used to hold the valve body 613 in a fixed position when the first case 611 and the second case 612 are joined in assembling the one-way valve 610. For example, the valve body 613 may be arranged with respect to the second case 612 in such a direction that the protruding portion 613b can be positioned within the second communication hole when the valve body 613 is brought into contact with the valve seat 612a. In this state, an elongated rod-shaped valve body fixing jig (not shown) is inserted into the upstream flow path 612b from the side opposite to the valve seat 612a of the second case 612. The tip of the valve body fixing jig has a structure that can fix the protrusion 613b, and this structure is used to fix the valve body 613 to the inserted valve body fixing jig. As a result, the valve body 613 is held in a fixed position with respect to the second case 612, so by joining the second case 612 and the first case 611 in this state, the valve body 610 can be assembled more easily. . After assembling the valve body 610, the valve body fixing jig is removed from the valve body 613.
　弁体６１３の球状の部分である本体６１３ａは形態１と比較して直径が大きく、弁室の容積に占める本体６１３ａの体積の割合である弁体占有率が形態１と比較して高い。弁体占有率は、弁室の容積をＶｃ、弁体６１３の本体６１３ｂの体積をＶｂとしたとき、Ｖｂ／Ｖｃ×１００（％）で表すことができる。弁体占有率を高くすることで、弁室内でのエアの滞留が抑制され、一方弁６１０内での流体の流れによるエアの抜けを向上させることができる。弁室内でのエアの滞留を効果的に抑制するためには、弁体占有率は８０％以上であることが好ましく、より好ましくは８５％以上、さらに好ましくは９０％以上である。一方、弁体占有率が高すぎると流体が流れにくくなるため、弁体占有率は９５％以下であることが好ましい。 The main body 613a, which is the spherical portion of the valve body 613, has a larger diameter compared to the first embodiment, and the valve body occupancy rate, which is the ratio of the volume of the main body 613a to the volume of the valve chamber, is higher than the first embodiment. The valve body occupancy rate can be expressed as Vb/Vc×100 (%), where the volume of the valve chamber is Vc and the volume of the main body 613b of the valve body 613 is Vb. By increasing the valve body occupancy rate, air retention within the valve chamber is suppressed, and air escape due to fluid flow within the one-way valve 610 can be improved. In order to effectively suppress air retention in the valve chamber, the valve body occupancy rate is preferably 80% or more, more preferably 85% or more, and even more preferably 90% or more. On the other hand, if the valve body occupancy rate is too high, it becomes difficult for fluid to flow, so the valve body occupancy rate is preferably 95% or less.
　弁体占有率を実用的な範囲で最大限とした場合、弁体６１３は、下流側では弁体位置規制突起６１１ｃと接触し、かつ、上流側では弁座６１２ａと接触するような大きさとすることができる。この場合、弁室内での弁体６１３の移動が困難であるので、弁体６１３はゴム等の弾性部材で形成し、弁体６１３の上流側において弁体６１３に作用する圧力の上昇に伴って弁体６１３が弾性変形することによって、一方弁６１０が開くように構成される。弁体６１３の弾性変形は、具体的には圧縮であり、図９Ｂに示すように、弁体６１３が下流側に向かって圧縮され、弁座６１２ａから離れ、これによって弁６１３が開く。一方、弁体６１３の上流側に作用する圧力が元に戻ると弁体６１３の形状が復元し、弁体６１３は弁座６１２ａに接触する。これによって一方弁が閉じる。 When the valve body occupancy rate is maximized within a practical range, the valve body 613 is sized so that it contacts the valve body position regulating protrusion 611c on the downstream side and contacts the valve seat 612a on the upstream side. be able to. In this case, since it is difficult for the valve body 613 to move within the valve chamber, the valve body 613 is formed of an elastic member such as rubber, and as the pressure acting on the valve body 613 increases on the upstream side of the valve body 613. The one-way valve 610 is configured to open by elastically deforming the valve body 613. Specifically, the elastic deformation of the valve body 613 is compression, and as shown in FIG. 9B, the valve body 613 is compressed toward the downstream side and moves away from the valve seat 612a, thereby opening the valve 613. On the other hand, when the pressure acting on the upstream side of the valve body 613 returns to its original state, the shape of the valve body 613 is restored and the valve body 613 comes into contact with the valve seat 612a. This closes the one-way valve.
　弁体６１３の材料としては、シリコーンゴムを用いることができる。圧力変化に伴う弁体６１３の弾性変形を生じさせるためには、弁体６１３の硬度は７０度以下であることが好ましく、より好ましくは５０度以下である。一方、圧力変化に伴う弁体６１３の過剰な弾性変形が生じると、上流側の圧力上昇に伴い弁体６１３が圧縮した際に、一方弁６１０の周方向全体にわたって弁体６１３が弁室の内面に接触して弁室を塞いでしまう開閉動作不良が生じる可能性がある。このような開閉動作不良を防止するため、弁体６１３の硬度は３０度以上であることが好ましく、より好ましくは４０度以上である。 As the material of the valve body 613, silicone rubber can be used. In order to cause elastic deformation of the valve body 613 in response to pressure changes, the hardness of the valve body 613 is preferably 70 degrees or less, more preferably 50 degrees or less. On the other hand, if excessive elastic deformation of the valve body 613 occurs due to pressure changes, when the valve body 613 is compressed due to an increase in pressure on the upstream side, the valve body 613 will be compressed on the inner surface of the valve chamber over the entire circumferential direction of the one-way valve 610. There is a possibility that the opening/closing operation may fail due to contact with the valve chamber and blocking the valve chamber. In order to prevent such opening/closing defects, the hardness of the valve body 613 is preferably 30 degrees or more, more preferably 40 degrees or more.
　以上一方弁６１０の形態２について説明したが、上述の説明において、弁体６１３の突出部６１３ｂは必須ではなく、形態１と同様、球状の部分のみであってもよい。逆に、形態１において、形態２と同様に、弁体６１３が突出部６１３ｂを有していてもよい。 Although the second form of the one-way valve 610 has been described above, in the above description, the protruding portion 613b of the valve body 613 is not essential, and like the first form, it may be only a spherical portion. Conversely, in the first embodiment, the valve body 613 may have the protrusion 613b, as in the second embodiment.
　［一方弁の形態３］
　図１０Ａに一方弁の形態３の斜視図を示し、図１０Ｂにその分解斜視図を示す。また、図１０Ｃに、形態３の一方弁の流体の流れ方向に沿った断面図を示す。形態３の基本的な構成は形態２と同じであり、第１ケース６１１、第２ケース６１２および弁体６１３を有する。ただし、形態３では第１ケース６１１の構造が形態２と異なる。以下、形態２と同じであってよい構成の説明は省略し、主に第１ケース６１１について説明する。 [One-way valve form 3]
FIG. 10A shows a perspective view of the third one-way valve, and FIG. 10B shows an exploded perspective view thereof. Further, FIG. 10C shows a cross-sectional view of the one-way valve of Form 3 along the fluid flow direction. The basic configuration of form 3 is the same as form 2, and includes a first case 611, a second case 612, and a valve body 613. However, in the third embodiment, the structure of the first case 611 is different from that in the second embodiment. Hereinafter, a description of the configuration that may be the same as that of the second embodiment will be omitted, and the first case 611 will be mainly described.
　第１ケース６１１は、図１０Ｃに示すように、ルアーロック式のコネクタとして機能する構造も有して構成されている。この第１ケース６１１に接続されるチューブにもこのコネクタと接続されるルアーロック式のコネクタが取り付けられており、ユーザが第１ケース６１１にチューブを着脱できるように構成されている。形態１で説明したように、第２ケース６１２もチューブを着脱できるように構成されているので、形態３によれば、ユーザがチューブから一方弁６１０を自由に取り外すことができる。このような、コネクタとして機能する構造を有する第１ケース６１１は、形態１に適用することもできる。 As shown in FIG. 10C, the first case 611 also has a structure that functions as a Luer lock type connector. A luer lock type connector connected to this connector is also attached to the tube connected to the first case 611, so that the user can attach and detach the tube to the first case 611. As described in the first embodiment, the second case 612 is also configured to allow the tube to be attached and removed, so according to the third embodiment, the user can freely remove the one-way valve 610 from the tube. The first case 611 having such a structure functioning as a connector can also be applied to Form 1.
　［一方弁の形態４］
　図１１Ａに一方弁の形態４の斜視図を示し、図１１Ｂにその分解斜視図を示す。また、図１１Ｃに、形態４の一方弁の流体の流れ方向に沿った断面図を示す。形態４の一方弁６２０も、形態１～３と同様、第１ケース６２１、第２ケース６２２および弁体６２３を有し、矢印１１Ａ方向のみへの薬液の流れを許容するが、それぞれ形態１～３とは形状および構造が異なり、形態４ではさらにガスケット６２４および付勢ばね６２５を有する。 [One-way valve form 4]
FIG. 11A shows a perspective view of form 4 of the one-way valve, and FIG. 11B shows an exploded perspective view thereof. Further, FIG. 11C shows a cross-sectional view of the one-way valve of Form 4 along the fluid flow direction. The one-way valve 620 of the fourth embodiment also has a first case 621, a second case 622, and a valve body 623, as in the first to third embodiments, and allows the flow of the chemical liquid only in the direction of the arrow 11A. The shape and structure are different from the configuration 3, and the configuration 4 further includes a gasket 624 and a biasing spring 625.
　第１ケース６２１および第２ケース６２２は、それぞれ下流側流路６２１ｂおよび上流側流路６２２ｂを有し、互いに接合されて弁室を形成する。第１ケース６２１と第２ケース６２２との接合方法および接合に関する構造は、形態１と同様であってよい。弁体６２３、ガスケット６２４および付勢ばね６２５は、弁室内に配置される。 The first case 621 and the second case 622 each have a downstream flow path 621b and an upstream flow path 622b, and are joined to each other to form a valve chamber. The method of joining the first case 621 and the second case 622 and the structure related to the joining may be the same as in the first embodiment. Valve body 623, gasket 624, and biasing spring 625 are arranged within the valve chamber.
　弁体６２３は、弁本体６２３ａ、脚部６２３ｂ、複数の第１凸部６２３ｃおよび第２凸部６２３ｄを有し、一方弁６２０の軸方向に移動可能に弁室内に位置する。弁本体６２３ａは、下流側端部がテーパ状に形成された弁体６２３の部分である。脚部６２３ａは、弁本体６２３ａの下流側端面から一方弁６２０の軸方向に延びる、一方弁６２０の部分である。第１凸部６２３ｃは、弁本体６２３ａの側面に形成され、一方弁６２０の径方向への弁本体６２３ａの動きを防止する。第２凸部６２３ｄは、ガスケット６２４を保持するために弁本体６２３ａの上流側端面に形成される。 The valve body 623 has a valve body 623a, a leg portion 623b, a plurality of first convex portions 623c, and a plurality of second convex portions 623d, and is located within the valve chamber so as to be movable in the axial direction of the one-way valve 620. The valve body 623a is a portion of the valve body 623 having a tapered downstream end. The leg portion 623a is a portion of the one-way valve 620 that extends in the axial direction of the one-way valve 620 from the downstream end surface of the valve body 623a. The first convex portion 623c is formed on the side surface of the valve body 623a, and prevents movement of the valve body 623a in the radial direction of the one-way valve 620. The second convex portion 623d is formed on the upstream end surface of the valve body 623a to hold the gasket 624.
　ガスケット６２４は、半球状の部材であり、球状の表面で上流側流路６２２ｂの弁室側の開口を塞ぐことができるように、球状の表面を上流側に向けて配置される。ガスケット６２４の下流側端面には凹部が形成され、この凹部に弁体６２３の第２凸部６２３ｄが嵌合することでガスケット６２４は弁本体６２３ａに保持される。ガスケット６２４の半球状の頂部には、形態２で説明した弁体６１３の突出部６１３ｂ（図９Ａ参照）と同様の突出部を有していてもよい。 The gasket 624 is a hemispherical member and is arranged with the spherical surface facing upstream so that the spherical surface can close the valve chamber side opening of the upstream flow path 622b. A recess is formed in the downstream end surface of the gasket 624, and the second protrusion 623d of the valve body 623 fits into the recess, thereby holding the gasket 624 on the valve body 623a. The hemispherical top of the gasket 624 may have a protrusion similar to the protrusion 613b (see FIG. 9A) of the valve body 613 described in the second embodiment.
　付勢ばね６２５は、弁体６２３を一方弁６２０の上流側に付勢できれば任意の手段を用いることができるが、形態４ではコイルばねを用いており、このコイルばねの内側に脚部６２３ｂが位置する。付勢ばね６２５のばね係数は、一方弁６２０を開閉動作すべき所定の圧力に応じて設定される。付勢ばね６２５のばね係数を適宜設定することで、薬液容器からシリンジへの薬液の吸引時に開く一方弁６２０、または、シリンジからの薬液の注入時に開く一方弁として用いることができる。 Any means can be used as the biasing spring 625 as long as it can bias the valve body 623 toward the upstream side of the one-way valve 620, but in the fourth embodiment, a coil spring is used, and the leg portion 623b is provided inside the coil spring. To position. The spring coefficient of the biasing spring 625 is set according to a predetermined pressure at which the one-way valve 620 is to be opened and closed. By appropriately setting the spring coefficient of the biasing spring 625, it can be used as a one-way valve 620 that opens when a drug solution is drawn from a drug solution container into a syringe, or as a one-way valve that opens when a drug solution is injected from a syringe.
　第１ケース６２１の下流側流路６２１ｂは、上流側から下流側に向かって段階的に直径が小さくなる第１の部分６２１Ｕ、第２の部分６２１Ｍおよび第３の部分６２１Ｌを有すように段付きに形成される。第１の部分６２１Ｕは、付勢ばね６２５は挿入可能であるが弁本体６２３ａは挿入不可である直径を有する。第２の部分６２１Ｍは、脚部６２３ｂは挿入可能であるが付勢ばね６２５は挿入不可である直径を有する。第３の部分６２１Ｌは、脚部６２３ｂが挿入不可である直径を有する。よって、第１の部分６２１Ｕと第２の部分６２１Ｍとの間の段差は付勢ばね６２５のストッパとして機能し、第２の部分６２１Ｍと第３の部分６２１Ｌとの間の段差は脚部６２３ｂのストッパとして機能する。ただし、これら段差の径方向での寸法は最小限となるように、脚部６２３ｂおよび付勢ばね６２５等の寸法を設計することが、一方弁６２０内での圧力損失の低減のために好ましい。また、一方弁６２０内の空間容積をできるだけ小さくすることは、一方弁６２０内でのエアの滞留を抑制し、エアの抜けをよくするうえで好ましい。 The downstream flow path 621b of the first case 621 has a first portion 621U, a second portion 621M, and a third portion 621L whose diameter gradually decreases from the upstream side to the downstream side. Formed with. The first portion 621U has a diameter that allows the biasing spring 625 to be inserted but not the valve body 623a. The second portion 621M has a diameter such that the leg 623b is insertable but the biasing spring 625 is not. The third portion 621L has a diameter such that the leg portion 623b cannot be inserted. Therefore, the step between the first portion 621U and the second portion 621M functions as a stopper for the biasing spring 625, and the step between the second portion 621M and the third portion 621L acts as a stopper of the leg portion 623b. Functions as a stopper. However, in order to reduce pressure loss within the one-way valve 620, it is preferable to design the dimensions of the leg portion 623b, the biasing spring 625, etc. so that the radial dimensions of these steps are minimized. Furthermore, it is preferable to make the space volume within the one-way valve 620 as small as possible in order to suppress the accumulation of air within the one-way valve 620 and improve air escape.
　上述した構成に基づき、一方弁６２０の上流側に作用する圧力が所定の圧力以下であるときは、弁体６２３ａが付勢ばね６２５によって上流側に付勢され、上流側流路６２２ｂの弁室側の開口がガスケット６２４によって塞がれている。すなわち、一方弁６２０は閉じている。一方弁６２０の上流側に作用する圧力が所定の圧力より大きくなるか、または弁室が陰圧になると、弁体６２３は付勢ばね６２５の付勢力に抗して下流側に移動する。これによって、ガスケット６２４が上流側流路６２２ｂの弁室側の開口から離れ、一方弁６２０が開く。 Based on the above-described configuration, when the pressure acting on the upstream side of the one-way valve 620 is lower than a predetermined pressure, the valve body 623a is urged upstream by the urging spring 625, and the valve chamber of the upstream flow path 622b is The side openings are closed by gaskets 624. That is, one-way valve 620 is closed. On the other hand, when the pressure acting on the upstream side of the valve 620 becomes greater than a predetermined pressure, or when the valve chamber becomes negative pressure, the valve body 623 moves downstream against the urging force of the urging spring 625. As a result, the gasket 624 moves away from the valve chamber side opening of the upstream flow path 622b, and the one-way valve 620 opens.
　　（Ｂ－ｃ）追加のユニット
　薬液回路３０は、追加のユニットをさらに含んでもよい。追加のユニットとしては、薬液容器（４０Ａ、４０Ｂ）からシリンジ（２０Ａ、２０Ｂ）へ薬液を吸引するために用いられる吸引チューブユニットが挙げられる。以下、吸引チューブユニットの一形態について、その斜視図である図１２、および吸引チューブユニットを構成する各部品の斜視図である図１２Ａ～１２Ｅを参照して説明する。 (Bc) Additional Unit The chemical liquid circuit 30 may further include an additional unit. Additional units include suction tube units used to aspirate medical fluids from medical fluid containers (40A, 40B) to syringes (20A, 20B). Hereinafter, one form of the suction tube unit will be described with reference to FIG. 12, which is a perspective view thereof, and FIGS. 12A to 12E, which are perspective views of each component constituting the suction tube unit.
　吸引チューブユニット４００は、チューブ本体４１０と、チューブ本体４１０の一端に接続された吸引弁４２０と、吸引弁４２０の開口端に着脱可能に取り付けられた、蓋付きの開閉ダストキャップ４３０と、チューブ本体４１０の他端に接続されたスパイク４４０と、スパイクキャップ４５０と、を有する。 The suction tube unit 400 includes a tube body 410, a suction valve 420 connected to one end of the tube body 410, an open/close dust cap 430 with a lid detachably attached to the open end of the suction valve 420, and a tube body. It has a spike 440 connected to the other end of 410 and a spike cap 450.
　吸引弁４２０は、第１ケース４２１と、第２ケース４２２と、弁体４２３と、コイルばね４２４と、を有する。第１ケース４２１および第２ケース４２２は、それぞれ流路を有し、第１ケース４２１と第２ケース４２２とが接合されることで、第１ケース４２１および第２ケース４２２の流路の間でこれら流路と連通する弁室が形成される。 The suction valve 420 includes a first case 421, a second case 422, a valve body 423, and a coil spring 424. The first case 421 and the second case 422 each have a flow path, and by joining the first case 421 and the second case 422, there is a flow path between the first case 421 and the second case 422. A valve chamber communicating with these channels is formed.
　弁体４２３およびコイルばね４２４は、弁室内に配置されている。弁室内において、弁体４２３はコイルばね４２４によって第２ケース４２２の流路に向けて付勢される。弁体４２３はコイルばね４２４の付勢力によって、第２ケース４２２の弁室への流路の開口を塞ぐが、弁体４２３を第１ケース４２１に向かって押し込むような力が弁体４２３に作用すると、弁体４２３はコイルばね４２４の付勢力に抗して第１ケース４２１側に移動し、これによって第２ケース４２２の流路の弁室側の開口が開放される。弁体４２３の先端部（第２ケース４２２側の端部）は、シリンジのノズル部の先端が当接したときに、ノズル部の開口を塞がず、かつ、シリンジの内部と弁室とが流体連通するような形状に形成されている。 The valve body 423 and the coil spring 424 are arranged within the valve chamber. Inside the valve chamber, the valve body 423 is urged toward the flow path of the second case 422 by a coil spring 424 . The valve body 423 closes the opening of the flow path to the valve chamber of the second case 422 due to the biasing force of the coil spring 424, but a force that pushes the valve body 423 toward the first case 421 acts on the valve body 423. Then, the valve body 423 moves toward the first case 421 against the urging force of the coil spring 424, thereby opening the opening of the flow path of the second case 422 on the valve chamber side. The tip of the valve body 423 (the end on the second case 422 side) does not block the opening of the nozzle when the tip of the nozzle of the syringe comes into contact with it, and also ensures that the inside of the syringe and the valve chamber are connected to each other. Shaped for fluid communication.
　第２ケース４２２の流路は、シリンジのノズル部を挿入することができる直径を有している。第２ケース４２２の流路の内面には、複数のリブ４２２ａが、流路の周方向に等間隔で形成されている。これらのリブ４２２ａは、シリンジのストッパとして機能し、シリンジが吸引弁４２０の奥まで入りすぎることを防止する。さらに、これらのリブ４２２ａは、弁体４２３の動作時のガイドとしても機能し、これによって弁体４２３を安定して動作させることができる。 The flow path of the second case 422 has a diameter that allows the nozzle portion of a syringe to be inserted therein. A plurality of ribs 422a are formed on the inner surface of the flow path of the second case 422 at equal intervals in the circumferential direction of the flow path. These ribs 422a function as a stopper for the syringe and prevent the syringe from entering too far into the suction valve 420. Furthermore, these ribs 422a also function as a guide during operation of the valve body 423, thereby allowing the valve body 423 to operate stably.
　スパイク４４０は、薬液容器と接続される部分であり、長手方向全体にわたって延びる薬液の導入路４４０ａを有する。スパイク４４０の先端部は先鋭な突き刺し部４４０ｂとして形成され、突き刺し部４４０ｂを薬液容器の栓部材に貫通させることで、薬液容器と導入路４４０ａとが流体連通する。この突き刺し操作においてユーザがスパイク４４０をしっかりホールドできるように、突き刺し部４４０ｂの根本部に一対のグリッパ４４０ｃが一体に設けられることが好ましい。グリッパ４４０ｃには、凹凸による滑り止め加工がなされていてもよい。また、突き刺し部４４０ｂには、導入路４４０ａとは別にエアベント４４０ｄが形成されている。エアベント４４０ｄの末端にはフィルタ４４１（図１２Ｄおよび１２Ｅでは不図示）が取り付けられている。 The spike 440 is a part connected to the chemical liquid container, and has a chemical liquid introduction path 440a extending over the entire lengthwise direction. The tip of the spike 440 is formed as a sharp piercing portion 440b, and by passing the piercing portion 440b through the plug member of the liquid medicine container, fluid communication is established between the liquid medicine container and the introduction path 440a. In order to enable the user to firmly hold the spike 440 during this stabbing operation, it is preferable that a pair of grippers 440c be integrally provided at the base of the stabbing portion 440b. The gripper 440c may be textured to prevent slipping. Furthermore, an air vent 440d is formed in the piercing portion 440b separately from the introduction path 440a. A filter 441 (not shown in FIGS. 12D and 12E) is attached to the end of the air vent 440d.
　ここで、第２ケース４２２の端部にはルアーロック式の連結構造が形成されている。一方、開閉ダストキャップ４３０には、第２ケース４２２の連結構造と噛み合うルアーロック式の連結構造が形成されている。これらの連結構造によって開閉ダストキャップ４３０は第２ケース４２２の端部に着脱自在に連結される。また、スパイク４４０の突き刺し部４４０ｂにはスパイクキャップ４５０が着脱自在に装着される。吸引チューブユニット４００の非使用時には、これら開閉ダストキャップ４３０およびスパイクキャップ４５０は、それぞれ吸引弁４２０およびスパイク４４０に装着されたままとされており、これによって、吸引チューブユニット４００への異物の混入が防止される。 Here, a Luer lock type connection structure is formed at the end of the second case 422. On the other hand, the opening/closing dust cap 430 is formed with a Luer lock type connection structure that engages with the connection structure of the second case 422. With these connection structures, the openable/closable dust cap 430 is detachably connected to the end of the second case 422. Further, a spike cap 450 is detachably attached to the piercing portion 440b of the spike 440. When the suction tube unit 400 is not in use, the open/close dust cap 430 and the spike cap 450 remain attached to the suction valve 420 and the spike 440, respectively, thereby preventing foreign matter from entering the suction tube unit 400. Prevented.
　次に、上述した吸引チューブユニット４００の使用手順について説明する。まず、開閉ダストキャップ４３０の蓋を開けるとともに、スパイクキャップ４５０を取り外す。次いで、スパイク４４０を薬液容器の栓部材に突き刺してから、吸引弁４２０の流路にシリンジのノズル部を挿入する。使用するシリンジは、薬液が充填されていない空シリンジであり、かつ、プランジャが最前進位置に位置しているシリンジである。吸引弁４２０にシリンジのノズル部を挿入することで弁体４２３が押し込まれ、これによって吸引弁４２０が開く。このようにして吸引チューブユニット４００を介して薬液容器とシリンジとを接続した後、シリンジのプランジャを後退させることで薬液容器からシリンジへ薬液が吸引される。薬液の吸引後は、シリンジのノズル部が吸引弁４２０から引き抜かれるとともに、スパイク４４０が薬液容器の栓部材から引き抜かれる。シリンジのノズル部が吸引弁４２０から引き抜かれることによって、弁体４２３はコイルばね４２４の付勢力によって元の位置に戻され、吸引弁４２０が閉じられる。 Next, the procedure for using the above-mentioned suction tube unit 400 will be explained. First, the lid of the retractable dust cap 430 is opened and the spike cap 450 is removed. Next, the spike 440 is pierced into the stopper member of the drug solution container, and then the nozzle portion of the syringe is inserted into the flow path of the suction valve 420. The syringe used is an empty syringe that is not filled with a drug solution, and is a syringe in which the plunger is located at the most advanced position. By inserting the nozzle portion of the syringe into the suction valve 420, the valve body 423 is pushed in, thereby opening the suction valve 420. After the drug solution container and the syringe are connected through the suction tube unit 400 in this manner, the plunger of the syringe is moved back to suck the drug solution from the drug solution container into the syringe. After suctioning the medicinal solution, the nozzle portion of the syringe is pulled out from the suction valve 420, and the spike 440 is pulled out from the plug member of the medicinal solution container. When the nozzle portion of the syringe is pulled out from the suction valve 420, the valve body 423 is returned to its original position by the biasing force of the coil spring 424, and the suction valve 420 is closed.
　　（Ｂ－ｄ）シリンジコネクタ
　シリンジと薬液回路とを接続するシリンジコネクタ３１０ａ、３２０ａは、薬液の注入および吸引動作中に薬液の漏れが生じなければその構造は特に限定されないが、シリンジコネクタの緩み防止機能を有していることが好ましい。 (B-d) Syringe Connector The syringe connectors 310a and 320a that connect the syringe and the medicinal liquid circuit are not particularly limited in structure as long as the medicinal liquid does not leak during the injection and suction operation of the medicinal liquid, but the syringe connector is prevented from loosening. It is preferable that it has a function.
　図１３に、緩み防止機能を有するシリンジコネクタおよびそのシリンジコネクタに対応するシリンジの側面図を示す。なお、図１３では、シリンジの下半分は断面で示している。図１３に示すシリンジコネクタ３６０は、シリンジ２２のノズル部が挿入されるキャップ状の部材であり、シリンジコネクタ３６０の内面には、シリンジ２２のノズル部に形成されたねじ山と噛み合うねじ溝が形成され、シリンジコネクタ３６０をシリンジ２２のノズル部にねじ込むことでシリンジコネクタ３６０とシリンジとを接続することができる。 FIG. 13 shows a side view of a syringe connector with a loosening prevention function and a syringe corresponding to the syringe connector. In addition, in FIG. 13, the lower half of the syringe is shown in cross section. The syringe connector 360 shown in FIG. 13 is a cap-shaped member into which the nozzle portion of the syringe 22 is inserted, and a thread groove that engages with a thread formed on the nozzle portion of the syringe 22 is formed on the inner surface of the syringe connector 360. By screwing the syringe connector 360 into the nozzle portion of the syringe 22, the syringe connector 360 and the syringe can be connected.
　シリンジコネクタ３６０の、シリンダ２２のノズル部が挿入される側と反対側の端部には、回転式のジョイントを介してチューブやＴ字管などの接続部材（図１３では不図示）が接続されている。シリンジコネクタ３６０の、シリンダ２２のノズル部が挿入される側の端部には、複数のコネクタ突起３６０ａが形成されている。コネクタ突起３６０ａは、シリンジコネクタ３６０の周方向に等間隔に配置され、シリンジコネクタ３６０をさらに延長するようにシリンジコネクタ３６０の長手方向に延びている。 A connecting member (not shown in FIG. 13) such as a tube or T-shaped pipe is connected to the end of the syringe connector 360 opposite to the side where the nozzle part of the cylinder 22 is inserted through a rotary joint. ing. A plurality of connector protrusions 360a are formed at the end of the syringe connector 360 on the side into which the nozzle portion of the cylinder 22 is inserted. The connector protrusions 360a are arranged at regular intervals in the circumferential direction of the syringe connector 360, and extend in the longitudinal direction of the syringe connector 360 so as to further extend the syringe connector 360.
　コネクタ突起３６０ａに対応して、シリンジ２２のノズル部にもその外面から突出する複数のシリンジ突起２２ｃが形成されている。シリンジ突起２２ｃは、シリンジ２２とシリンジコネクタ３６０とが接続されたときにコネクタ突起３６０ａの間に位置するような位置、形状および寸法で形成される。 In correspondence with the connector protrusion 360a, a plurality of syringe protrusions 22c are also formed on the nozzle portion of the syringe 22 and protrude from its outer surface. The syringe protrusion 22c is formed in such a position, shape, and size that it is located between the connector protrusion 360a when the syringe 22 and the syringe connector 360 are connected.
　シリンジ２２とシリンジコネクタ３６０との接続において、シリンジコネクタ３６０をシリンジ２２のノズル部にねじ込んでいくと、コネクタ突起３６０ａがシリンジ突起２２ｃに当たり、シリンジコネクタ３６０はシリンジ突起２２ｃによる抵抗を受ける。ここで、シリンジコネクタ３６０は、シリンジコネクタ３６０をさらに回転させるとコネクタ突起３６０ａが弾性変形してシリンジ突起２２ｃを乗り越えることができるような材料および寸法で構成される。よって、ユーザは、シリンジコネクタ３６０によりに大きな力を加え、シリンジコネクタ３６０をさらに回転させてシリンジ２２のノズル部にねじ込むことができる。 In connecting the syringe 22 and the syringe connector 360, as the syringe connector 360 is screwed into the nozzle portion of the syringe 22, the connector protrusion 360a hits the syringe protrusion 22c, and the syringe connector 360 receives resistance from the syringe protrusion 22c. Here, the syringe connector 360 is constructed of materials and dimensions such that when the syringe connector 360 is further rotated, the connector protrusion 360a is elastically deformed and can overcome the syringe protrusion 22c. Therefore, the user can apply greater force to the syringe connector 360 and further rotate the syringe connector 360 to screw it into the nozzle portion of the syringe 22.
　シリンジコネクタ３６０が最後までねじ込まれ、シリンジ２２に完全に接続されると、シリンジ突起２２ｃの間にコネクタ突起３６０ａが位置する。この状態では、シリンジ２２とシリンジコネクタ３６０とを相対的に回転させるためには、コネクタ突起３６０ａが弾性変形してシリンジ突起２２ｃを乗り越えることができるような力を加える必要があり、このことが結果的にシリンジ２２の緩み防止機能として働く。 When the syringe connector 360 is screwed all the way in and is completely connected to the syringe 22, the connector protrusion 360a is located between the syringe protrusions 22c. In this state, in order to relatively rotate the syringe 22 and syringe connector 360, it is necessary to apply a force that allows the connector protrusion 360a to elastically deform and overcome the syringe protrusion 22c. It functions as a function to prevent the syringe 22 from loosening.
　コネクタ突起３６０ａがシリンジ突起２２ｃを乗り越えることによって、ユーザにはクリック感が与えられる。クリック感が与えられることによって、ユーザはシリンジコネクタ３６０がシリンジ２２のノズル部にねじ込まれていることを感覚的に把握することができる。クリック感の大きさは、シリンジコネクタ３６０の材料、コネクタ突起３６０ａの寸法、およびシリンジ突起２２ｃの寸法を適宜設計することによって任意に設定可能である。 A clicking sensation is given to the user by the connector protrusion 360a climbing over the syringe protrusion 22c. By providing a click feeling, the user can intuitively understand that the syringe connector 360 is screwed into the nozzle portion of the syringe 22. The magnitude of the click feeling can be arbitrarily set by appropriately designing the material of the syringe connector 360, the dimensions of the connector protrusion 360a, and the dimensions of the syringe protrusion 22c.
　［Ｃ］注入ヘッドの構成
　次に、図１に示した注入ヘッド１０ａについて、図１４などを参照して説明する。注入ヘッド１０ａは、シリンジが搭載されるヘッド本体１０１、ヘッド本体１０１の前方（シリンジが搭載される側）に配置された薬液回路動作ユニット１０２および薬液容器４０Ａ、４０Ｂ（図１参照）を保持する薬液容器ホルダ１０３を有する。 [C] Configuration of Injection Head Next, the injection head 10a shown in FIG. 1 will be described with reference to FIG. 14 and the like. The injection head 10a holds a head main body 101 on which a syringe is mounted, a chemical liquid circuit operating unit 102 arranged in front of the head main body 101 (on the side on which the syringe is mounted), and chemical liquid containers 40A and 40B (see FIG. 1). It has a drug solution container holder 103.
　（Ｃ－ａ）ヘッド本体
　ヘッド本体１０１の主な機能は、シリンジを搭載し、搭載したシリンジを操作することである。そのためヘッド本体１０１は、図１５に示すように２つのシリンジ２０Ａ、２０Ｂ（図１参照）を着脱可能に固定するクランパ１１１と、プレッサ１１２と、操作部１１３とを有する。 (C-a) Head Body The main function of the head body 101 is to mount a syringe and operate the syringe mounted thereon. Therefore, the head main body 101 includes a clamper 111 that removably fixes the two syringes 20A and 20B (see FIG. 1), a presser 112, and an operating section 113, as shown in FIG.
　クランパ１１１は、第１保持構造１１１ａと、第１保持構造１１１ａと協働してシリンジを保持する２つの第２保持構造１１１ｂとを有することができる。第１保持構造１１１ａは、２つのシリンジの末端のフランジ部分（図３に示す形態では、保護カバー２１のカバーフランジ２１ａ）の周方向の一部を受け入れる２つの凹部を有する。第２保持構造１１１ｂは、第１保持構造１１１ａの各凹部に対応して配置され、各凹部に受け入れられたフランジ部分の残りの少なくとも一部を受け入れることができる凹部を有して構成される。 The clamper 111 can have a first holding structure 111a and two second holding structures 111b that cooperate with the first holding structure 111a to hold the syringe. The first holding structure 111a has two recesses that receive circumferential portions of the end flange portions of the two syringes (in the form shown in FIG. 3, the cover flanges 21a of the protective cover 21). The second holding structure 111b is arranged to correspond to each recess of the first holding structure 111a, and is configured to have a recess capable of receiving at least a portion of the remaining flange portion received in each recess.
　第２保持構造１１１ｂは、第１保持構造１１１ａに対する開放位置と閉止位置との間を移動可能に支持され、閉止位置において、第１保持構造１１１ａと協働してシリンジのフランジ部分を、シリンジの長手方向へは移動不能に保持する。ここで、「移動不能」とは、対象となる構造体が全く動かないことのみならず、設計上の寸法公差等により生じるクリアランスの範囲内で移動することも含む。 The second holding structure 111b is supported movably between an open position and a closed position with respect to the first holding structure 111a, and in the closed position, cooperates with the first holding structure 111a to hold the flange portion of the syringe. It is held immovable in the longitudinal direction. Here, "immovable" includes not only that the target structure does not move at all, but also that it moves within the range of clearance caused by design dimensional tolerances.
　プレッサ１１２は、モータ等の駆動源によって進退移動可能とされ、シリンジ駆動機構の一部を構成する。プレッサ１１２の先端部には、シリンジのプランジャ（またはピストン）と係合する係合部を有する。この係合部がプランジャ（またはピストン）に係合し、かつ、クランパ１１１によってシリンジが保持された状態でプレッサ１１２を前進および後退させることで、プランジャ（またはピストン）がシリンダに対して前進および後退する。これによって、シリンジから薬液を注入したり、シリンジ内に薬液を吸引したりすることができる。 The presser 112 is movable forward and backward by a drive source such as a motor, and constitutes a part of the syringe drive mechanism. The tip of the presser 112 has an engaging portion that engages with a plunger (or piston) of a syringe. This engaging portion engages with the plunger (or piston), and by moving the presser 112 forward and backward with the syringe held by the clamper 111, the plunger (or piston) moves forward and backward with respect to the cylinder. do. Thereby, it is possible to inject a medicinal solution from the syringe or to aspirate the medicinal solution into the syringe.
　操作部１１３は、プレッサ１１２を動作させるための、前進ボタン、後退ボタンなど複数のボタンを有し、注入制御ユニット１１（図１参照）で設定された条件とは別にユーザが所望に応じてプレッサ１１２を動作させることができる。 The operation unit 113 has a plurality of buttons, such as a forward button and a backward button, for operating the presser 112. 112 can be operated.
　また、ヘッド本体１０１は、搭載されるシリンジの長手方向に直角な方向に延びるサポートシャフト１１４を有することができる。ヘッド本体１０１は、サポートシャフト１１４を介して、スタンド（不図示）または天井から延びる旋回アーム（不図示）に、サポートシャフト１１４を中心として回動自在に支持されることができる。サポートシャフト１１４を略水平方向に向けた状態でヘッド本体１０１を支持することによって、ヘッド本体１０１は、シリンジの先端を天井側へ向けた姿勢（上向き姿勢）にと、シリンジの先端を床面側へ向けた姿勢（下向き姿勢）との間で回動自在に支持することができる。 Further, the head main body 101 can have a support shaft 114 extending in a direction perpendicular to the longitudinal direction of the syringe to be mounted. The head main body 101 can be rotatably supported via the support shaft 114 on a stand (not shown) or a pivot arm (not shown) extending from the ceiling. By supporting the head main body 101 with the support shaft 114 oriented substantially horizontally, the head main body 101 can be placed in a posture with the tip of the syringe facing the ceiling (upward posture) and with the tip of the syringe facing the floor. It can be supported rotatably between the facing position (downward facing position) and the downward facing position.
　（Ｃ－ｂ）薬液回路動作ユニット
　薬液回路動作ユニット１０２は、薬液回路３０の単数回使用部３００Ａ（図２参照）が着脱自在に装着され、この単数回使用部３００Ａの各流路を制御する複数の機構を有する。これらの機構は、電気的に駆動されるものであり、これらの機構に薬液がかからないように、これらの機構は、薬液回路３０を引き回すために必要な部分を除いて、ケーシング内に収容されている。 (C-b) Chemical liquid circuit operating unit The chemical liquid circuit operating unit 102 is detachably attached to the single-use portion 300A (see FIG. 2) of the chemical liquid circuit 30, and controls each flow path of the single-use portion 300A. It has multiple mechanisms. These mechanisms are electrically driven and are housed in a casing, except for the parts necessary for routing the chemical liquid circuit 30, so that the chemical liquid does not come into contact with these mechanisms. There is.
　薬液回路動作ユニット１０２は、ヘッド本体１０１に固定されていてもよい。薬液回路動作ユニット１０２をヘッド本体１０１に固定することで、薬液回路３０を構成するチューブが折れ曲がったりすることなく薬液回路３０を整然と配置することができる。 The chemical liquid circuit operation unit 102 may be fixed to the head main body 101. By fixing the chemical liquid circuit operating unit 102 to the head main body 101, the chemical liquid circuit 30 can be arranged in an orderly manner without bending the tubes forming the chemical liquid circuit 30.
　薬液回路動作ユニット１０２が備える機構としては、エアセンサ７１０、７８０、押しつぶし機構７２０、７３０、７５０、流路開閉弁駆動機構７４０を挙げることができる。これらはコンソール１０ｂ（図１参照）の注入制御ユニット１１によって動作が制御される。また、これらの位置については図２に示している。 Mechanisms included in the chemical liquid circuit operating unit 102 include air sensors 710, 780, crushing mechanisms 720, 730, 750, and flow path opening/closing valve drive mechanism 740. The operations of these are controlled by the injection control unit 11 of the console 10b (see FIG. 1). Further, these positions are shown in FIG.
　（Ｃ－ｂ１）エアセンサ
　エアセンサは、流路内のエアを検出する。図２を参照すると、２つのエアセンサ７１０は、それぞれ薬液回路３０の第１および第２メインライン３０１ａ、３０２ａの第２チューブ３１５ａ、３２５ｂ内でのエアの存在を検出する。エアセンサ７８０は、薬液回路３０のトランスデューサライン３０４の第８チューブ３４０内でのエアの存在を検出する。これらエアセンサ７１０、７８０としては、チューブ内のエアを検出できるものであれば、公知の任意のセンサを用いることができる。エアセンサの一例として、チューブを間において対向配置された送信器および受信器を有する超音波式のセンサを挙げることができる。 (C-b1) Air Sensor The air sensor detects air in the flow path. Referring to FIG. 2, two air sensors 710 detect the presence of air within the second tubes 315a, 325b of the first and second main lines 301a, 302a of the chemical circuit 30, respectively. Air sensor 780 detects the presence of air within eighth tube 340 of transducer line 304 of chemical circuit 30 . As these air sensors 710 and 780, any known sensor can be used as long as it can detect air inside the tube. An example of an air sensor is an ultrasonic sensor having a transmitter and a receiver placed opposite each other with a tube in between.
　（Ｃ－ｂ２）押しつぶし機構
　押しつぶし機構７２０、７３０、７５０は、チューブを押しつぶしたり開放したりするように動作することによって、流路の開放および閉鎖を制御する。押しつぶし機構７２０、７３０は、エアセンサ７１０、７８０の近傍に配置することができる。エアセンサ７１０、７８０の近傍であれば、押しつぶし機構７２０、７３０はエアセンサ７１０、７８０の上流側に配置されていてもよいし、下流側に配置されていてもよい。エアセンサ７１０、７８０によりエアが検出されたときに押しつぶし機構７２０、７３０の制御により効果的に被検者へのエア到達を妨げる閉止動作をするためには、エアセンサ７１０、７８０よりも被検者側（下流側）に押しつぶし機構７２０、７３０が配置されることが好ましい。押しつぶし機構７５０は、第６チューブ３３５に配置することができる。押しつぶし機構７２０、７３０、７５０は、例えば、チューブがおかれるベースと、ベースにスライド可能に支持された押し部材と、を有することができる。ベースにチューブを配置した状態で、押し部材をベースに向けて移動させ、ベースおよび押し部材でチューブを押しつぶすことによって流路を閉鎖することができる。 (C-b2) Squeezing mechanism The squishing mechanisms 720, 730, and 750 control opening and closing of the flow path by operating to crush and open the tube. The squeezing mechanism 720, 730 can be placed near the air sensor 710, 780. As long as it is near the air sensors 710, 780, the crushing mechanisms 720, 730 may be placed upstream or downstream of the air sensors 710, 780. In order to perform a closing operation that effectively prevents air from reaching the subject by controlling the crushing mechanisms 720, 730 when air is detected by the air sensors 710, 780, it is necessary to It is preferable that crushing mechanisms 720 and 730 are arranged (on the downstream side). A crushing mechanism 750 can be disposed on the sixth tube 335. The crushing mechanism 720, 730, 750 can have, for example, a base on which the tube is placed, and a pushing member slidably supported by the base. With the tube placed on the base, the push member can be moved toward the base and the tube can be crushed by the base and the push member to close the flow path.
　（Ｃ－ｂ３）流路開閉弁駆動機構
　流路開閉弁駆動機構７４０は、流路開閉弁３３２（図４等参照）を装着し、流路開閉弁３３２を駆動することによって、流路開閉弁３３２内の流路を開放したり閉鎖したりするための機構である。 (C-b3) Channel opening/closing valve drive mechanism The passage opening/closing valve driving mechanism 740 is equipped with a passage opening/closing valve 332 (see FIG. 4, etc.) and drives the passage opening/closing valve 332. This is a mechanism for opening and closing the flow path within 332.
　流路開閉弁駆動機構７４０は、流路の開放および閉鎖を制御することができればその構成は特に限定されず、例えば、流路開閉弁３３２を着脱自在に保持するホルダと、流路開閉弁３３２のピストン５０２（図４参照）と係合する係合部であるフックと、フックを移動させる機構とを有することができる。流路開閉弁駆動機構７４０は、流路開閉弁駆動機構７４０に流路開閉弁３３２が装着されているか否かを検出するセンサをさらに備えることができる。そのようなセンサとしては、特に限定されず、流路開閉弁駆動機構７４０に装着された流路開閉弁３３２が装着されていることを検出できる任意のセンサを用いることができる。 The structure of the flow path opening/closing valve drive mechanism 740 is not particularly limited as long as it can control the opening and closing of the flow path. The device may include a hook, which is an engaging portion that engages with the piston 502 (see FIG. 4), and a mechanism for moving the hook. The flow path on-off valve drive mechanism 740 can further include a sensor that detects whether or not the flow path on-off valve 332 is attached to the flow path on-off valve drive mechanism 740 . Such a sensor is not particularly limited, and any sensor that can detect that the flow path opening/closing valve 332 attached to the flow path opening/closing valve drive mechanism 740 is attached can be used.
　なお、図２に示す薬液回路３０では、トランスデューサライン３０４に押しつぶし機構７３０が配置されているが、その代わりに、トランスデューサライン３０４に流路開閉弁３３２を配置し、押しつぶし機構７３０を流路開閉弁３３２に置き換えてもよい。 Note that in the chemical liquid circuit 30 shown in FIG. 2, a crushing mechanism 730 is arranged in the transducer line 304, but instead, a flow path opening/closing valve 332 is arranged in the transducer line 304, and the crushing mechanism 730 is used as a flow path opening/closing valve. 332 may be substituted.
　（Ｃ－ｂ４）流路開閉弁の照明
　薬液回路動作ユニット１０２は、流路開閉弁駆動機構７４０に装着された流路開閉弁３３２を照明する照明モジュールを有することができる。これにより、薬液回路動作ユニット１０２に装着された流路開閉弁３３２が視認し易くなる。照明モジュールは、光源を含み、照明モジュールによる照明方式は任意であってよい。光源としては、例えば発光ダイオードなど任意の光源を用いることができる。照明モジュールは、流路開閉弁が流路開閉弁駆動機構に装着されているときのみ流路開閉弁を照明するようにすることが好ましい。これにより、流路開閉弁が流路開閉弁駆動機構に装着されていることをユーザが視覚的に容易に認識できる。 (C-b4) Illumination of flow path on-off valve The chemical liquid circuit operation unit 102 can have a lighting module that illuminates the flow path on-off valve 332 attached to the flow path on-off valve drive mechanism 740. This makes it easier to visually recognize the channel opening/closing valve 332 attached to the chemical liquid circuit operation unit 102. The lighting module includes a light source, and the lighting method by the lighting module may be arbitrary. As the light source, any light source such as a light emitting diode can be used. It is preferable that the lighting module illuminates the flow path on-off valve only when the flow path on-off valve is attached to the flow path on-off valve drive mechanism. Thereby, the user can easily visually recognize that the channel opening/closing valve is attached to the channel opening/closing valve drive mechanism.
　（Ｃ－ｃ）薬液容器ホルダ
　薬液容器ホルダ１０３は、薬液容器４０Ａ、４０Ｂを着脱自在に保持するものであり、吊り下げ式に、注入ヘッド１０ａまたは薬液回路動作ユニット１０２に取り付けられることができる。薬液容器ホルダ１０３は、図２に示す第１サブライン３０１ｂおよび第２サブライン３０２ｂ内のエアを検出するエアセンサ８４１を有していてもよい。エアセンサ８４１としては、超音波式のエアセンサなど任意のセンサを用いることができる。 (Cc) Chemical Solution Container Holder The drug solution container holder 103 detachably holds the drug solution containers 40A and 40B, and can be attached to the injection head 10a or the drug solution circuit operation unit 102 in a suspended manner. The chemical liquid container holder 103 may include an air sensor 841 that detects air in the first subline 301b and the second subline 302b shown in FIG. 2. As the air sensor 841, any sensor such as an ultrasonic air sensor can be used.
　［Ｄ］薬液注入装置の動作
　次に、上述した薬液注入装置の動作について、流路開閉弁３３２、および押しつぶし機構７２０、７３０、７５０の動作を中心に説明する。これらの動作は、注入制御ユニット１１によって制御される。以下の説明では、第１メインライン３０１ａおよび第１サブライン３０１ｂが造影剤（Ａ）のライン、第２メインライン３０２ａおよび第２サブライン３０２ｂが生理食塩水（Ｂ）のラインである場合について説明する。また、説明の簡略化のため、造影剤を「Ａ」、生理食塩水を「Ｂ」と表記する。また、以下の説明において、「押しつぶし機構が開かれる」とは、その上流側と下流側との間で流路が開放されるように、押しつぶし機構が駆動されることを意味する。同様に、「押しつぶし機構が閉じられる」とは、その上流側と下流側との間で流路が閉鎖されるように、押しつぶし機構が駆動されることを意味する。また、トランスデューサライン３０４において、押しつぶし機構７３０が流路開閉弁駆動機構７４０に置き換えられる場合は、以下の説明における押しつぶし機構７３０の動作は、置き換えられた流路開閉弁駆動機構７４０の動作として読み替えることができる。 [D] Operation of the chemical liquid injector Next, the operation of the chemical liquid injector described above will be explained, focusing on the operation of the channel opening/closing valve 332 and the crushing mechanisms 720, 730, and 750. These operations are controlled by the injection control unit 11. In the following description, a case will be described in which the first main line 301a and the first sub-line 301b are contrast agent (A) lines, and the second main line 302a and second sub-line 302b are physiological saline (B) lines. Moreover, for the sake of simplicity of explanation, the contrast medium is written as "A" and the physiological saline solution is written as "B". Furthermore, in the following description, "the crushing mechanism is opened" means that the crushing mechanism is driven so that the flow path is opened between the upstream side and the downstream side thereof. Similarly, "the crushing mechanism is closed" means that the crushing mechanism is driven such that the flow path is closed between its upstream and downstream sides. In addition, in the transducer line 304, when the crushing mechanism 730 is replaced with the flow path opening/closing valve drive mechanism 740, the operation of the crushing mechanism 730 in the following description can be read as the operation of the replaced flow path opening/closing valve driving mechanism 740. I can do it.
　（Ｄ－ａ）電源ＯＮ
　薬液注入装置の電源ＯＮ時は、各押しつぶし機構７２０、７３０、７５０および流路開閉弁３３２は開いている。 (D-a) Power ON
When the liquid injector is powered on, each of the crushing mechanisms 720, 730, 750 and the channel opening/closing valve 332 are open.
　（Ｄ－ｂ）セルフチェック
　セルフチェックでは、各押しつぶし機構７２０、７３０、７５０および流路開閉弁３３２は、正常に動作するかの確認が行われる。 (Db) Self-check In the self-check, it is confirmed whether each crushing mechanism 720, 730, 750 and flow path opening/closing valve 332 operate normally.
　（Ｄ－ｃ）セットアップ
　（ｃ１）マルチキット（複数回使用部３００Ｂ）
　薬液回路３０の複数回使用部３００Ｂのセットアップ時は、各押しつぶし機構７２０、７３０、７５０および流路開閉弁３３２は、いずれも開いた状態のままとされる。 (D-c) Setup (c1) Multi-kit (multiple use part 300B)
When setting up the multi-use section 300B of the chemical liquid circuit 30, each of the crushing mechanisms 720, 730, 750 and the flow path opening/closing valve 332 are all kept open.
　（ｃ２）シングルキット（単数回使用部３００Ａ）
　薬液回路３０の単数回使用部３００Ａのセットアップ時（チューブ装着後）は、流路開閉弁３３２、トランスデューサライン３０４の押しつぶし機構７３０および第６チューブ３３５の押しつぶし機構７５０は開いた状態とされるが、Ａ側およびＢ側の押しつぶし機構７２０は閉じられる。 (c2) Single kit (single use part 300A)
When setting up the single-use portion 300A of the chemical liquid circuit 30 (after the tube is attached), the flow path opening/closing valve 332, the crushing mechanism 730 of the transducer line 304, and the crushing mechanism 750 of the sixth tube 335 are in an open state. The A-side and B-side crushing mechanisms 720 are closed.
　（Ｄ－ｄ）注入条件設定画面（チェック、スタンバイ、スタートＯＫ）
　注入条件設定時には、Ａ側およびＢ側の押しつぶし機構７２０は閉じられる。また、流路開閉弁３３２は閉じられ、トランスデューサライン３０４の押しつぶし機構７３０および第６チューブ３３５の押しつぶし機構７５０は開かれる。 (D-d) Injection condition setting screen (check, standby, start OK)
When setting injection conditions, the A-side and B-side crushing mechanisms 720 are closed. Further, the flow path opening/closing valve 332 is closed, and the crushing mechanism 730 of the transducer line 304 and the crushing mechanism 750 of the sixth tube 335 are opened.
　（Ｄ－ｅ）注入、プライミング（エア抜き）、マニュアル前進（前進ボタン）
　（ｅ１）Ａ注入またはＡプライミング
　造影剤の注入中または造影剤ライン（第１メインラインおよび被検者ライン）のプライミング中は、Ａ側の押しつぶし機構７２０は開かれ、Ｂ側の押しつぶし機構７２０は閉じられる。また、流路開閉弁３３２は開かれ、トランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (De) Injection, priming (air release), manual advance (forward button)
(e1) A injection or A priming During injection of contrast medium or priming of contrast medium lines (first main line and subject line), the A side crushing mechanism 720 is opened, and the B side crushing mechanism 720 is opened. Closed. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.
　（ｅ２）Ｂ注入またはＢプライミング
　生理食塩水の注入中または生理食塩水ライン（第２メインラインおよび被検者ライン）のプライミング中は、Ａ側の押しつぶし機構７２０は閉じられ、Ｂ側の押しつぶし機構７２０は開かれる。また、流路開閉弁３３２は開かれ、トランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (e2) B injection or B priming During injection of physiological saline or priming of the physiological saline line (second main line and subject line), the A side crushing mechanism 720 is closed, and the B side crushing mechanism 720 is opened. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.
　（ｅ３）Ａ+Ｂ注入またはＡ+Ｂプライミング
　造影剤および生理食塩水の同時注入中、またはその場合の注入ライン（第１メインライン、第２メインラインおよび被検者ライン）のプライミング中は、Ａ側およびＢ側の押しつぶし機構７２０が開かれる。また、流路開閉弁３３２は開かれ、トランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (e3) A+B injection or A+B priming During simultaneous injection of contrast medium and saline, or during priming of the injection lines (first main line, second main line, and subject line) in that case, The A-side and B-side crushing mechanisms 720 are opened. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.
　トランスデューサライン３０４の押しつぶし機構７３０の開閉タイミングについては、トランスデューサが保護される圧力範囲で、注入タイミングに応じて閉鎖することが好ましい。注入後の残圧がある場合は、残圧による影響を避けるため、注入後の所定の時間後に開放してもよい。 Regarding the opening and closing timing of the crushing mechanism 730 of the transducer line 304, it is preferable to close it in accordance with the injection timing within a pressure range in which the transducer is protected. If there is residual pressure after injection, it may be opened a predetermined time after injection to avoid the influence of the residual pressure.
　（ｅ４）Ａ前進
　注入ヘッド１０ａのＡ側の前進ボタンが操作された場合（すなわち、Ａ側のシリンジのプランジャのマニュアルによる前進操作が行われた場合）、その操作がなされている間、Ａ側の押しつぶし機構７２０は開かれ、Ｂ側の押しつぶし機構７２０は、閉じられる。また、流路開閉弁３３２は開かれ、トランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (e4) Advance A When the advance button on the A side of the injection head 10a is operated (that is, when the plunger of the syringe on the A side is manually advanced), while the operation is being performed, the A side The crushing mechanism 720 on the B side is opened, and the crushing mechanism 720 on the B side is closed. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.
　（ｅ５）Ｂ前進
　注入ヘッド１０ａのＢ側の前進ボタンが操作された場合（すなわち、Ｂ側のシリンジのプランジャのマニュアルによる前進操作が行われた場合）、その操作がなされている間、Ａ側の押しつぶし機構７２０は閉じられ、Ｂ側の押しつぶし機構７２０は、開かれる。また、流路開閉弁３３２は開かれ、トランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (e5) B advance When the advance button on the B side of the injection head 10a is operated (that is, when the plunger of the B side syringe is manually advanced), while the operation is being performed, the A side The crushing mechanism 720 on the B side is closed, and the crushing mechanism 720 on the B side is opened. Further, the channel opening/closing valve 332 is opened and the crushing mechanism 730 of the transducer line 304 is closed.
　（ｅ６）トランスデューサ―ラインのプライミング
　トランスデューサ―ラインのプライミング中は、Ａ側の押しつぶし機構７２０は閉じられ、Ｂ側の押しつぶし機構７２０、流路開閉弁３３２、およびトランスデューサライン３０４の押しつぶし機構７３０は開かれる。第６チューブ３３５の押しつぶし機構７５０は閉じられる。トランスデューサラインのプライミング時に押しつぶし機構７５０を閉じることで、好適にプライミングを行うことができる。 (e6) Priming of the transducer line During priming of the transducer line, the crushing mechanism 720 on the A side is closed, and the crushing mechanism 720 on the B side, the flow path opening/closing valve 332, and the crushing mechanism 730 of the transducer line 304 are opened. . The crushing mechanism 750 of the sixth tube 335 is closed. By closing the crushing mechanism 750 when priming the transducer line, priming can be suitably performed.
　（Ｄ－ｆ）フラッシュ
　生理食塩水によるフラッシュの間は、Ｂ側の押しつぶし機構７２０および流路開閉弁３３２は開かれ、Ａ側の押しつぶし機構７２０およびトランスデューサライン３０４の押しつぶし機構７３０は閉じられる。 (Df) Flush During flushing with physiological saline, the B-side crushing mechanism 720 and flow path opening/closing valve 332 are opened, and the A-side crushing mechanism 720 and the crushing mechanism 730 of the transducer line 304 are closed.
　（Ｄ－ｇ）吸引
　薬液容器からシリンジへの薬液の吸引の間、Ａ側およびＢ側の押しつぶし機構７２０は閉じられている。また、流路開閉弁３３２は閉じられているが、トランスデューサライン３０４の押しつぶし機構７３０および第６チューブ３３５の押しつぶし機構７５０は開かれている。薬液の吸引時に流路開閉弁や押しつぶし機構の上流側の与圧が低減する可能性がある場合は、吸引終了後に与圧を行ってもよい。 (Dg) Suction During suction of the medical solution from the medical solution container into the syringe, the crushing mechanisms 720 on the A side and B side are closed. Furthermore, although the flow path opening/closing valve 332 is closed, the crushing mechanism 730 of the transducer line 304 and the crushing mechanism 750 of the sixth tube 335 are open. If there is a possibility that the pressurization on the upstream side of the channel opening/closing valve or the crushing mechanism is reduced during suction of the chemical solution, pressurization may be performed after suction is completed.
　（Ｄ－ｈ）終了－シングルキット取り外し
　各種動作が終了し、シングルキットが取り外される際は、Ａ側およびＢ側の押しつぶし機構７２０、流路開閉弁３３２、トランスデューサライン３０４の押しつぶし機構７３０および第６チューブ３３５の押しつぶし機構７５０は、開かれる。 (Dh) Completion - Single Kit Removal When various operations are completed and the single kit is removed, the crushing mechanisms 720 on the A side and B side, the flow path opening/closing valve 332, the crushing mechanism 730 on the transducer line 304, and the sixth Squeezing mechanism 750 of tube 335 is opened.
　（Ｄ－ｉ）エア検出
　エアセンサによってエアの存在が検出されると、Ａ側およびＢ側の押しつぶし機構７２０、流路開閉弁３３２、およびトランスデューサライン３０４の押しつぶし機構７３０は、閉じられる。 (Di) Air Detection When the presence of air is detected by the air sensor, the crushing mechanisms 720 on the A side and B side, the flow path opening/closing valve 332, and the crushing mechanism 730 on the transducer line 304 are closed.
　
　１０　　薬液注入装置
　１０ａ　　注入ヘッド
　１０ｂ　　コンソール
　２２　　シリンジ
　２２ａ　　フランジ
　２２ｂ　　ノズル部
　２２ｃ　　シリンジ突起
　３０　　薬液回路
　１０１　　ヘッド本体
　１０２　　薬液回路動作ユニット
　１０３　　薬液容器ホルダ
　１１１　　クランパ
　１１２　　プレッサ
　１１３　　操作部
　３０１ａ　　第１メインライン
　３０１ｂ　　第１サブライン
　３０２ａ　　第２メインライン
　３０２ｂ　　第２サブライン
　３０３　　被検者ライン
　３０４　　トランスデューサライン
　３３２　　流路開閉弁
　３６０　　シリンジコネクタ
　３６０ａ　　コネクタ突起
　４００　　吸引チューブユニット
　４１０　　チューブ本体
　４２０　　吸引弁
　４２１　　第１ケース
　４２２　　第２ケース
　４２３　　弁体
　４２４　　コイルばね
　４３０　　開閉ダストキャップ
　４４０　　スパイク
　４４０ａ　　導入路
　４４０ｂ　　突き刺し部
　４４０ｄ　　エアベント
　４４１　　フィルタ
　５０１　　ハウジング
　５０１ａ、５０１ｂ　　導管部
　５０２　　ピストン
　５０２ａ　　ヘッド
　５０３　　ストッパ構造
　５０３ａ　　凸部
　５０３ｂ　　凹部
　５０６　　封止リング
　６１０、６２０　　一方弁
　６１０ａ　　弁室
　６１１、６２１　　第１ケース
　６１１ａ　　受入れ凹部
　６１１ｂ、６２１ｂ　　下流側流路
　６１１ｃ　　弁体位置規制突起
　６１２、６２２　　第２ケース
　６１２ａ　　弁座
　６１２ｂ、６２２ｂ　　上流側流路
　６１３、６２３　　弁体
　６２４　　ガスケット
　６２５　　付勢ばね
　７１０、７８０　　エアセンサ
　７２０、７３０　　押しつぶし機構
　７４０　　流路開閉弁駆動機構
　８４１　　エアセンサ
10 Chemical injection device 10a Injection head 10b Console 22 Syringe 22a Flange 22b Nozzle part 22c Syringe protrusion 30 Chemical liquid circuit 101 Head main body 102 Chemical liquid circuit operation unit 103 Chemical liquid container holder 111 Clamper 112 Presser 113 Operation part 301a 1st main line 301b 1st sub line 302a 2nd main line 302b 2nd subline 303 Subject line 304 Transducer line 332 Channel opening/closing valve 360 Syringe connector 360a Connector protrusion 400 Suction tube unit 410 Tube body 420 Suction valve 421 1st case 422 2nd case 423 Valve body 424 Coil spring 430 Opening/closing dust cap 440 Spike 440a Introduction path 440b Pierce part 440d Air vent 441 Filter 501 Housing 501a, 501b Conduit part 502 Piston 502a Head 503 Stopper structure 503a Convex part 503b Recess part 506 Sealing ring 610, 62 0 One-way valve 610a Valve chamber 611 , 621 First case 611a Receiving recess 611b, 621b Downstream passage 611c Valve body position regulating protrusion 612, 622 Second case 612a Valve seat 612b, 622b Upstream passage 613, 623 Valve body 624 Gasket 625 Biasing spring 710, 780 Air sensor 720, 730 Squeezing mechanism 740 Channel opening/closing valve drive mechanism 841 Air sensor

Claims (6)

  1. 　薬液回路に用いられる流路開閉弁であって、
    　流入路および排出路を備えたハウジングと、
    　開位置および閉位置を取り得るように前記ハウジング内にスライド自在に挿入されたピストンと、
    　前記ハウジングに対する前記ピストンの移動範囲を制限する、凸部と、前記ピストンのスライド方向に延びて前記凸部を受け入れる凹部とを有するストッパ構造と、
    　を有し、
    　前記凹部は、前記ピストンが前記開位置に位置するときに前記凸部が当接する第１端部と、前記ピストンが前記閉位置に位置するときに前記凸部が当接する第２端部とを有するように長さが定められ、かつ、
    　前記ハウジングおよび前記ピストンの一方に前記凸部が形成され、他方に前記凹部が形成されている、流路開閉弁。     A flow path opening/closing valve used in a chemical liquid circuit,
    a housing with an inlet and an outlet;
    a piston slidably inserted into the housing so as to be capable of assuming open and closed positions;
    a stopper structure having a convex portion that limits a movement range of the piston relative to the housing, and a recess that extends in a sliding direction of the piston and receives the convex portion;
    has
    The concave portion has a first end portion that the convex portion abuts when the piston is in the open position, and a second end portion that the convex portion abuts when the piston is in the closed position. the length is determined so as to have, and
    A flow path opening/closing valve, wherein the convex portion is formed on one of the housing and the piston, and the concave portion is formed on the other.
  2. 　前記ハウジングは貫通孔を有し、前記貫通孔内に前記ピストンがスライド自在に挿入されている、請求項１に記載の流路開閉弁。 The flow path opening/closing valve according to claim 1, wherein the housing has a through hole, and the piston is slidably inserted into the through hole.
  3. 　前記ピストンは、前記開位置および前記閉位置において、少なくとも一方の端部が前記貫通孔から突出している請求項２に記載の流路開閉弁。 The flow path opening/closing valve according to claim 2, wherein at least one end of the piston protrudes from the through hole in the open position and the closed position.
  4. 　前記ピストンの両端が前記貫通孔から突出いている請求項３に記載の流路開閉弁。 The flow path opening/closing valve according to claim 3, wherein both ends of the piston protrude from the through hole.
  5. 　前記凹部は、前記ハウジングの外周面に形成され、
    　前記凸部は、前記ピストンの一方の端部から前記ハウジングの外周面に回り込んで延びて形成されている、
    　請求項２～４のいずれか一項に記載の流路開閉弁。     The recess is formed on the outer peripheral surface of the housing,
    The convex portion is formed to extend from one end of the piston to the outer peripheral surface of the housing.
    The flow path opening/closing valve according to any one of claims 2 to 4.
  6. 　請求項１に記載の流路開閉弁を有する薬液回路。

          A chemical liquid circuit comprising the flow path opening/closing valve according to claim 1.
PCT/JP2023/015093 2022-04-14 2023-04-13 Flow path opening/closing valve for chemical circuit, and chemical circuit comprising said flow path opening/closing valve WO2023199992A1 (en)

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US8388603B1 (en) * 2009-03-19 2013-03-05 Steven Friedman Device for detraction of fluid from flow line for temporary storage and later use
JP2015217032A (en) * 2014-05-15 2015-12-07 泉工医科工業株式会社 Liquid injection/blood sampling branch tube device
WO2020158830A1 (en) * 2019-01-29 2020-08-06 株式会社サーキュラス Opening/closing unit drive mechanism for drug solution circuit, and drug solution injection device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388603B1 (en) * 2009-03-19 2013-03-05 Steven Friedman Device for detraction of fluid from flow line for temporary storage and later use
JP2015217032A (en) * 2014-05-15 2015-12-07 泉工医科工業株式会社 Liquid injection/blood sampling branch tube device
WO2020158830A1 (en) * 2019-01-29 2020-08-06 株式会社サーキュラス Opening/closing unit drive mechanism for drug solution circuit, and drug solution injection device

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