WO2023175363A1 - Method for optimizing the effect of the use of cannabinoids with terpenes - Google Patents
Method for optimizing the effect of the use of cannabinoids with terpenes Download PDFInfo
- Publication number
- WO2023175363A1 WO2023175363A1 PCT/IB2022/000088 IB2022000088W WO2023175363A1 WO 2023175363 A1 WO2023175363 A1 WO 2023175363A1 IB 2022000088 W IB2022000088 W IB 2022000088W WO 2023175363 A1 WO2023175363 A1 WO 2023175363A1
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- WIPO (PCT)
- Prior art keywords
- terpenes
- effect
- oil
- optimizing
- cannabinoids
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Definitions
- Terpenes are considered to be aerosols that promote human health and are emitted in particular by forest trees.
- Cannabinoids are active ingredients of the cannabis plant that - with or without the intoxicating THC - counteract psychological states of tension.
- Tension headaches can be divided into chronic and episodic. In chronic pain, attempts are made to address the general cause, but in episodic, painkillers are largely relied upon. i i
- the inventive step to overcome this is to first define the specifics of cannabiols according to their origin and to determine those combinations that best realize the desired effects.
- CBD oil is offered by “maschinetician heiligen Andreas” as free of gluten, vegan, with full-spectrum entourage effect, free of synthetic ingredients and as a natural CBD extract.
- the THC content in such oils is so low that no intoxicating effect is to be expected.
- Patent US9744200 describes a process of supercritical CO2 extraction for the production of a cannabidiol extract.
- the carbon dioxide is used as a solvent in this process.
- the plants are crushed, heated and decarboxylated. During this process, a carbon molecule splits off from the cannabinoids in the plant. Since these are naturally present as acids, it is only after the cleavage that the familiar cannabidiols are formed.
- the extracted substances are separated from each other by pressure and temperature. Due to the overall complex process, it is possible to achieve a strong entourage effect, as the production is very gentle and none of the ingredients are eradicated.
- the mixture of two different cannabis oils is proposed.
- One of the oils contains only the terpenes of the particular variety of the plant used, while the other oil contains only the corresponding cannabinoids.
- Steam distillation is used to extract the terpenes from the cannabis flower material as essential oils. This is done by heating to the boiling point of the terpenes until they change to a gaseous state. By capturing and cooling the gas, liquid terpenes are obtained.
- the concentration of the oil is very high, it is mixed with a hemp oil, obtained from the seeds of the plant, in an adjusted ratio.
- the process of obtaining the cannabinoids in an oil is decarboxylation. Since the active ingredients are present as acids in the plant, the plant material must be activated by heating to convert the acids into the cannabinoids.
- the cannabinoids dissolve and combine with the hemp oil.
- hemp oils produced are mixed together according to the recipe and the intended effect, aiming for an approximately equal ratio of terpenes and cannabinoids.
- Fig. 1 shows the basic process for producing a cannabidoids oil with entourage effect.
- cannabis flower material (1) is subjected to steam distillation (2). During this process, the material is heated to the boiling point of the terpenes, causing them to volatilize as gas.
- the task of the process is to capture the gas and cool it to a liquid, wherein essential oil (3) is obtained.
- this intermediate has a very high concentration, it is mixed with an oil obtained from hemp seeds (4).
- plant material (1a) is treated with decarboxylation (2a).
- decarboxylation (2a) the material is heated to such an extent that the acids present in the plant are converted into cannabidiols.
- hemp oil (3a) By boiling in hemp oil (3a), the cannabidiols are bound in the liquid and cannabinoid oil (4a) is obtained.
- Fig. 2 shows an example symbolic representation for terpenes in a plant. In the process, an oil is produced using only the terpenes of the plant.
- Fig. 3 shows a representation of a cannabis plant to symbolize cannabinoids.
- the cannabinoid oil is mixed with the terpene oil to form a combined oil.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cannabinoids are selected and combined with terpenes for application in such a way that a self-reinforcing effect results.
Description
Method for optimizing the effect of the use of cannabiniods with terpenes.
BACKGROUND OF THE INVENTION
Terpenes are considered to be aerosols that promote human health and are emitted in particular by forest trees.
Their intensity is appreciated by a growing community through applications of “forest bath- mg .
Cannabinoids are active ingredients of the cannabis plant that - with or without the intoxicating THC - counteract psychological states of tension.
In their combination of both groups of active ingredients, the so-called “entourage effect" is sought, which in a defined composition significantly increases the effect of the individual components.
In Germany, around 29 million people are affected by tension headaches. The most common causes of these pains are stress and long-lasting incorrect posture, for example at work. The consequences are tension and insomnia.
Tension headaches can be divided into chronic and episodic. In chronic pain, attempts are made to address the general cause, but in episodic, painkillers are largely relied upon. i i
With prolonged use of common painkillers, unpleasant side effects often occur. After a certain period of use, the symptoms may even worsen. Thus, a gentle means of treating the pain is still missing.
TASK OF THE INVENTION/PROBLEM TO BE SOLVED
It is therefore the task of the present invention to find a method by which certain combinations of terpenes and cannabinoids of hemp plants can be optimized and applied under changing conditions, such as provenance of origin, growing conditions, as well as storage and processing. Furthermore, wherein a remedy free of side effects against tension headaches shall be provided.
Up to now it is valid that the entourage effect occurs above all, if the components of a plant in by extract or other procedures occurred conditions as little as possible disturbed and natural remains.
On the other hand, with active ingredients imported by various trade routes, this is hardly feasible.
The inventive step to overcome this is to first define the specifics of cannabiols according to their origin and to determine those combinations that best realize the desired effects.
From our own findings and experience, three cannabis strains have emerged whose constituents are complementary and yield the desired effects for reducing tension headaches: Research Genetics (THC-Victory), Haze/Skunk X High CBD variety, Unhybridised Afghan Indica.
PRIOR ART
The website “Apotheke zum heiligen Andreas” (Last accessed on 05.11.2021 : https://www. andreas-apotheke.at/de/magazin/detail/320/was-bedeutet-entourage-effekt-bei-cbd.html) describes the entourage effect, which states that an intake of cannabidioles is strongest when the active ingredients of a hemp plant are taken in combination.
Known is the use of the effect in CBD oil. Such an oil is offered by “Apotheke zum heiligen Andreas” as free of gluten, vegan, with full-spectrum entourage effect, free of synthetic ingredients and as a natural CBD extract.
As a rule, the THC content in such oils is so low that no intoxicating effect is to be expected. i
The website “Hanfosan” (Last accessed on 05.11 .2021 : https://www.hanfosan.de/cbd-oel- herstellung.html) describes various extraction methods for the production of cannabidiol oil from hemp plants.
To achieve the entourage effect of a plant, extraction with supercritical carbon dioxide had to be applied so far, because with other methods the effectiveness of the final product, due to the loss of one or more active ingredients, decreases.
The effect of the combined ingredients is stronger than the sum of the individual substances.
Patent US9744200 describes a process of supercritical CO2 extraction for the production of a cannabidiol extract.
The carbon dioxide is used as a solvent in this process.
In processing, the plants are crushed, heated and decarboxylated. During this process, a carbon molecule splits off from the cannabinoids in the plant. Since these are naturally present
as acids, it is only after the cleavage that the familiar cannabidiols are formed.
In the further steps, the extracted substances are separated from each other by pressure and temperature. Due to the overall complex process, it is possible to achieve a strong entourage effect, as the production is very gentle and none of the ingredients are eradicated.
SOLUTION
As a solution, the mixture of two different cannabis oils is proposed. One of the oils contains only the terpenes of the particular variety of the plant used, while the other oil contains only the corresponding cannabinoids.
Steam distillation is used to extract the terpenes from the cannabis flower material as essential oils. This is done by heating to the boiling point of the terpenes until they change to a gaseous state. By capturing and cooling the gas, liquid terpenes are obtained.
Since the concentration of the oil is very high, it is mixed with a hemp oil, obtained from the seeds of the plant, in an adjusted ratio.
The process of obtaining the cannabinoids in an oil is decarboxylation. Since the active ingredients are present as acids in the plant, the plant material must be activated by heating to convert the acids into the cannabinoids.
By boiling the material in hemp oil, the cannabinoids dissolve and combine with the hemp oil.
The hemp oils produced are mixed together according to the recipe and the intended effect, aiming for an approximately equal ratio of terpenes and cannabinoids.
CLOSER DESCRIPTION ALONG TO THE DRAWING
Fig. 1 shows the basic process for producing a cannabidoids oil with entourage effect. To obtain an oil containing only terpenes (5), cannabis flower material (1) is subjected to steam distillation (2). During this process, the material is heated to the boiling point of the terpenes, causing them to volatilize as gas.
The task of the process is to capture the gas and cool it to a liquid, wherein essential oil (3) is obtained. However, since this intermediate has a very high concentration, it is mixed with an oil obtained from hemp seeds (4).
To produce a cannabinoid oil (4a), plant material (1a) is treated with decarboxylation (2a). In this process, the material is heated to such an extent that the acids present in the plant are converted into cannabidiols. By boiling in hemp oil (3a), the cannabidiols are bound in the liquid and cannabinoid oil (4a) is obtained.
In the last step, the two oils obtained so far are mixed (6) and an oil with entourage effect (7) is obtained.
Fig. 2 shows an example symbolic representation for terpenes in a plant. In the process, an oil is produced using only the terpenes of the plant.
Fig. 3 shows a representation of a cannabis plant to symbolize cannabinoids. The cannabinoid oil is mixed with the terpene oil to form a combined oil. i i
Claims
1 . Method for optimizing the effect of the application of cannabiniods and terpenes, wherein at least two different oils from one or more cannabis varieties are used.
2. Method for optimizing the effect of the application of cannabiniods and terpenes according to claim 1 , wherein at least one of the oils contains terpenes from one or more cannabis varieties.
3. Method for optimizing the effect of the application of cannabiniods and terpenes according to claim 1 , wherein at least one of the oils contains cannabiniode from one or more cannabis varieties.
4. Method for optimizing the effect of the application of cannabiniods with terpenes according to claim 2, wherein the terpenes are obtained as essential oils.
5. Method for optimizing the effect of the application of cannabiniods with terpenes according to claim 2, wherein the cannabiniods are obtained by decarboxylation and boiling from hemp oil.
6. Method for optimizing the effect of the application of cannabiniode with terpenes according to claim 2, wherein the terpenes are obtained as essential oils. i
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2022/000088 WO2023175363A1 (en) | 2022-03-17 | 2022-03-17 | Method for optimizing the effect of the use of cannabinoids with terpenes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2022/000088 WO2023175363A1 (en) | 2022-03-17 | 2022-03-17 | Method for optimizing the effect of the use of cannabinoids with terpenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023175363A1 true WO2023175363A1 (en) | 2023-09-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2022/000088 WO2023175363A1 (en) | 2022-03-17 | 2022-03-17 | Method for optimizing the effect of the use of cannabinoids with terpenes |
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| WO (1) | WO2023175363A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9744200B1 (en) | 2017-01-19 | 2017-08-29 | Oak and Crane, LLC | System for producing a terpene-enhanced cannabinoid concentrate |
| US20180296617A1 (en) * | 2017-04-18 | 2018-10-18 | Jose Rivas | Apparatus for preparation of pharmacologically-relevant compounds from botanical sources |
| US20180296616A1 (en) * | 2017-04-18 | 2018-10-18 | Jose Rivas | Method for preparation of pharmacologically-relevant compounds from botanical sources |
| US20180344786A1 (en) * | 2017-06-06 | 2018-12-06 | NC3 Systems | System and method enhanced cannabiniod effect delivery |
-
2022
- 2022-03-17 WO PCT/IB2022/000088 patent/WO2023175363A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9744200B1 (en) | 2017-01-19 | 2017-08-29 | Oak and Crane, LLC | System for producing a terpene-enhanced cannabinoid concentrate |
| US20180296617A1 (en) * | 2017-04-18 | 2018-10-18 | Jose Rivas | Apparatus for preparation of pharmacologically-relevant compounds from botanical sources |
| US20180296616A1 (en) * | 2017-04-18 | 2018-10-18 | Jose Rivas | Method for preparation of pharmacologically-relevant compounds from botanical sources |
| US20180344786A1 (en) * | 2017-06-06 | 2018-12-06 | NC3 Systems | System and method enhanced cannabiniod effect delivery |
Non-Patent Citations (2)
| Title |
|---|
| ETHAN B RUSSO: "Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 163, no. 7, 12 July 2011 (2011-07-12), pages 1344 - 1364, XP071102687, ISSN: 0007-1188, DOI: 10.1111/J.1476-5381.2011.01238.X * |
| TERNELLI MARCO ET AL: "Innovative methods for the preparation of medical Cannabis oils with a high content of both cannabinoids and terpenes", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, ELSEVIER B.V, AMSTERDAM, NL, vol. 186, 6 April 2020 (2020-04-06), XP086187960, ISSN: 0731-7085, [retrieved on 20200406], DOI: 10.1016/J.JPBA.2020.113296 * |
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