WO2023157851A1 - Composition aqueuse transparente - Google Patents

Composition aqueuse transparente Download PDF

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Publication number
WO2023157851A1
WO2023157851A1 PCT/JP2023/005089 JP2023005089W WO2023157851A1 WO 2023157851 A1 WO2023157851 A1 WO 2023157851A1 JP 2023005089 W JP2023005089 W JP 2023005089W WO 2023157851 A1 WO2023157851 A1 WO 2023157851A1
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Prior art keywords
cholesterol
surfactant
composition
mass
composition according
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PCT/JP2023/005089
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English (en)
Japanese (ja)
Inventor
千晶 高梨
典弘 高尾
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第一三共ヘルスケア株式会社
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Priority to JP2024501390A priority Critical patent/JPWO2023157851A1/ja
Priority to CN202380020881.0A priority patent/CN118660691A/zh
Publication of WO2023157851A1 publication Critical patent/WO2023157851A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a transparent aqueous composition containing cholesterol.
  • Cholesterol is one of the components that form the lamellar structure in the stratum corneum of the epidermis, and plays an important role in maintaining the barrier function. It is thought that when the ability to synthesize cholesterol in the epidermis decreases, the barrier function decreases, resulting in a decrease in the ability to recover from rough skin. Therefore, cholesterol is generally added to cosmetics, quasi-drugs, pharmaceuticals, etc., in hopes of maintaining the barrier function and improving rough skin. However, cholesterol is an oil-soluble substance that is solid at room temperature, and has a problem that it has low solubility in cosmetic base materials (especially, water-based cosmetic base materials) and can be blended in only a small amount.
  • Solubilization is known as a method for stably dispersing an oily component in an aqueous medium. Solubilization is the thermodynamically stable incorporation of a substance that is poorly soluble or insoluble in water, such as an oily component, into a water-based solvent using a solubilizer such as a surfactant to form a transparent or translucent liquid. Say. Solubilization of various oil-based materials has been attempted so far, but it is generally difficult to solubilize highly crystalline oil-based materials such as cholesterol, and various studies on blending alcohols and fatty acid esters have been conducted.
  • Patent Document 1 a nonionic surfactant in the range of HLB 11 to 16, diglyceryl monoisostearate and/or diglyceryl monooleate, an anionic surfactant, cholesterol and/or phytosterol, and ethanol are blended.
  • a solubilized composition characterized by: Another method for stably dispersing an oily component in an aqueous medium is an emulsification method.
  • an emulsified composition containing cholesterol usually becomes cloudy, and it is difficult to make a transparent composition, and there is also a problem with the feeling of use.
  • composition that can stably disperse cholesterol in an aqueous medium and has excellent transparency is desired.
  • the present invention includes the following embodiments.
  • [1] (a) cholesterol, (b) a surfactant having a sterol skeleton, and (c) water, A transparent aqueous composition in which the mass ratio of (b) a surfactant having a sterol skeleton to (a) cholesterol ((b) surfactant having a sterol skeleton/(a) cholesterol) is 4 or more.
  • the composition according to [1] further comprising (d) a polyol.
  • [3] (a) The composition according to [1] or [2], wherein the content of cholesterol is 0.1 to 3% by mass relative to the total amount of the composition.
  • the surfactant having a sterol skeleton has a mass ratio to (a) cholesterol ((b) surfactant having a sterol skeleton/(a) cholesterol) of 5 to 10, [1] The composition according to any one of - [3]. [5] (b) The composition according to any one of [1] to [4], wherein the surfactant having a sterol skeleton contains at least one of polyoxyethylene cholesteryl ether and polyoxyethylene phytosteryl ether. . [6] The composition according to [5], wherein (b) the surfactant having a sterol skeleton has 12 to 25 moles of added polyoxyethylene.
  • a novel transparent aqueous composition containing cholesterol is provided.
  • the transparent aqueous composition can be suitably used as cosmetics, quasi-drugs, pharmaceuticals and the like (for example, cosmetics and external preparations for skin).
  • the clear aqueous composition has at least one of high transparency, good stability, etc. (preferably high transparency and good stability).
  • the transparent aqueous composition can inhibit or reduce cholesterol sedimentation and can be suitably used in dosage forms such as mists, sprays or lotions.
  • the transparent aqueous composition is capable of stably solubilizing high concentrations of cholesterol.
  • FIG. 1 is a photograph showing the appearance of the cosmetic compositions prepared in Examples 1-5 and Comparative Examples 1-3.
  • FIG. 2 is a photograph showing the appearance of the cosmetic compositions prepared in Examples 6-10.
  • FIG. 3 is a photograph showing the appearance of the cosmetic compositions prepared in Examples 11-13.
  • FIG. 4 is a photograph showing the appearance of the cosmetic compositions prepared in Examples 14-17.
  • FIG. 5 is a photograph showing the appearance of the cosmetic compositions prepared in Examples 18-22.
  • FIG. 6 is a photograph showing the appearance of the cosmetic compositions prepared in Example 23 and Comparative Examples 4-5.
  • transparent aqueous composition comprises (a) cholesterol, (b) a surfactant having a sterol skeleton, and (c) water.
  • the mass ratio of (b) a surfactant having a sterol skeleton to (a) cholesterol ((b) a surfactant having a sterol skeleton/(a) cholesterol) is 4 or more.
  • compositions By blending (a) cholesterol together with (b) a surfactant having a sterol skeleton at a specific (b)/(a) ratio, (a) cholesterol is stably dispersed in an aqueous medium containing water. and transparent compositions can be obtained.
  • the term “transparent” means that the transmittance of light at a wavelength of 700 nm is 20% or higher (preferably 40% or higher, more preferably 60% or higher, even more preferably 80% or higher, and particularly preferably 95% or higher). means that In this specification, the transmittance of light at a wavelength of 700 nm can be measured with an ultraviolet-visible absorption photometer.
  • Transparent compositions include, in addition to completely transparent compositions, “translucent" compositions having a transmittance in the above range.
  • an "aqueous" composition refers to one in which the external phase of the composition is an aqueous component.
  • the transparent aqueous composition has a (b)/(a) ratio of 4 or more. If the (b)/(a) ratio is less than 4, cholesterol sedimentation will occur and the transparency will decrease.
  • the (b)/(a) ratio is preferably 5 or more, more preferably 6 or more, from the viewpoint of excellent transparency and reduction or suppression of white turbidity and cholesterol sediment.
  • the upper limit of the (b)/(a) ratio is not particularly limited, it is preferably 10 or less, more preferably 9 or less, and even more preferably 8 or less from the viewpoint of feeling during use.
  • the (b)/(a) ratio is preferably 4-10, more preferably 5-10, even more preferably 6-10.
  • the (b)/(a) ratio can be 4-8, or 5-9, or 6-8.
  • the transparent aqueous composition contains (a) cholesterol, (b) a surfactant having a sterol skeleton, and (c) water, as described above.
  • the transparent aqueous composition further contains (d) a polyol and (e) other components ((e1) other oily components, (e2) other surfactants, (e3) other aqueous components) as necessary. It's okay.
  • a polyol and (e) other components ((e1) other oily components, (e2) other surfactants, (e3) other aqueous components
  • Cholesterol Cholesterol contained in the transparent aqueous composition is preferably 0.1 to 3% by mass relative to the total amount (total mass) of the transparent aqueous composition. If the content of cholesterol is 0.1 to 3% by mass of the transparent aqueous composition, skin care effects such as enhancing the barrier function of the skin, suppressing evaporation of water from the inside of the skin, and enhancing moisturizing power can be obtained. and can be suitably used, for example, as cosmetics. In general, as the cholesterol concentration increases, cholesterol sedimentation and cloudiness tend to occur more easily. From the viewpoint of transparency and stability (reduction/suppression of cholesterol sediment/white turbidity), the content is more preferably 0.1 to 2% by mass, still more preferably 0.1 to 1.5% by mass, and particularly preferably is 0.1 to 1.0% by mass.
  • the transparent aqueous composition contains a surfactant having a sterol skeleton.
  • a surfactant having a sterol skeleton together with cholesterol, cholesterol can be stably dispersed in water, thereby obtaining a composition with excellent transparency and reduced or suppressed cholesterol sedimentation and white turbidity.
  • a surfactant having a sterol skeleton in the present invention is a surfactant having a sterol skeleton in the lipophilic group (hydrophobic portion).
  • a sterol skeleton is an alcohol having a hydroxy group bonded to the 3-position of a cyclopentanohydrophenanthrene ring shown in the following formula, and a surfactant having a sterol skeleton is a compound having a hydrophilic group bonded to this sterol skeleton.
  • the symbols A to D in the following formula represent each ring constituting the cyclopentanohydrophenanthrene ring, and the numbers represent the position numbers of the carbon atoms constituting the cyclopentanohydrophenanthrene ring.
  • the sterol skeleton of the lipophilic group may have a double bond on the cyclopentanohydrophenanthrene ring.
  • sterols having a double bond in the B ring or stanols composed of a saturated ring are preferred.
  • phytosterols such as ⁇ -sitosterol, campesterol, stigmasterol, and brassicasterol, or stanols thereof, cholesterol, cholestanol, lanosterol, ergosterol, and the like, preferably phytosterols and phytostanols.
  • cholesterol, cholestanol more preferably phytosterol or cholesterol.
  • Hydrophilic groups are not particularly limited, and examples include polyoxyalkylene chains (e.g., polyoxyethylene (POE) chains, polyoxypropylene (POP) chains, etc.), polyglycerin, polyglucosides, sorbitan, nonionic groups such as sucrose.
  • anionic hydrophilic groups such as carboxylates, sulfonates, sulfates and phosphates; and cationic hydrophilic groups such as aliphatic amine salts and quaternary ammonium salts.
  • Alkylene in the polyoxyalkylene chain preferably has 1 to 4 carbon atoms, more preferably 1 or 2 carbon atoms, and particularly preferably ethylene.
  • the hydrophilic group is preferably a nonionic hydrophilic group, more preferably a polyoxyalkylene chain, and still more preferably a polyoxyethylene (POE) chain.
  • the number of added moles of polyoxyalkylene chains is not particularly limited, but is preferably 12 or more, more preferably 15 or more, and still more preferably 18 or more.
  • the number of added moles of polyoxyalkylene chains is preferably 25 or less, more preferably 24 or less, and still more preferably 22 or less.
  • the number of added moles of the polyoxyalkylene chain (preferably polyoxyethylene (POE)) is preferably 12-25, more preferably 15-24, even more preferably 18-22. is.
  • Surfactants having a sterol skeleton are, for example, polyoxyalkylene ether-bonded to the sterol skeleton, more specifically, polyoxyalkylene cholesteryl ether (e.g., POE cholesteryl ether, POP cholesteryl ether), poly Oxyalkylene phytosteryl ether (e.g. POE phytosteryl ether, POP phytosteryl ether), Polyoxyalkylene cholestanol (e.g. POE cholestanol, POP cholestanol), Polyoxyalkylene phytostanol (e.g. POE phytostanol, POP phytosteryl ether) stanol) and the like, but are not limited to these.
  • polyoxyalkylene cholesteryl ether e.g., POE cholesteryl ether, POP cholesteryl ether
  • poly Oxyalkylene phytosteryl ether e.g. POE phytosteryl ether, POP phytosteryl ether
  • the surfactant having a sterol skeleton is preferably at least one of polyoxyethylene cholesteryl ether and polyoxyethylene phytosteryl ether from the viewpoint of transparency and stability.
  • POE (12-25, more preferably 15-24, still more preferably 18-22) cholesterol and POE (12-25, more preferably 15-24, still more preferably 18-22) phytosteryl ether are preferred.
  • the HLB (Hydrophilic-Lipophilic Balance) of the surfactant having a sterol skeleton is not particularly limited, it is preferably 11 or more, more preferably 12 or more from the viewpoint of improving transparency.
  • the HLB of the surfactant having a sterol skeleton is not particularly limited, but is preferably 16 or less, more preferably 15 or less.
  • the HLB of the surfactant having a sterol skeleton is preferably in the range of 11-16, more preferably in the range of 12-15. In this specification, unless otherwise specified, the HLB value is determined experimentally by comparing emulsifying power with a standard sample.
  • Any surfactant having the sterol skeleton may be used as long as it has the above properties, and commercially available products may be used.
  • Commercially available products include, for example, the EALEX CS series (EMALEX CS-15, EALEX CS-20, EALEX CS-24, etc.) manufactured by Nippon Emulsion Co., Ltd., and the NIKKOL BPS series (NIKKOL BPS-20, etc.) manufactured by Nikko Chemicals Co., Ltd. etc., but not limited to these.
  • surfactants having a sterol skeleton can be used singly or in combination of two or more.
  • the content of (b) a surfactant having a sterol skeleton in the transparent aqueous composition is not particularly limited, but is preferably 0.5 to 10% by mass relative to the total amount of the composition from the viewpoint of feeling during use.
  • Water Water is not particularly limited as long as it is commonly used in cosmetics. For example, tap water, ion-exchanged water, distilled water, purified water, etc. can be used.
  • the content of water is not particularly limited, but from the viewpoint of transparency, it is preferably 60% by mass or more, more preferably 70% by mass or more, and even more preferably 80% by mass or more.
  • the upper limit is not particularly limited, it is, for example, 99.5% by mass or less, or 97% by mass or less, or 95% by mass or less.
  • the water content in the transparent aqueous composition is preferably 60 to 99.5% by mass, more preferably 70 to 97% by mass, more preferably 80 to 95% by mass, based on the total amount of the composition. More preferred.
  • the transparent aqueous composition may contain other aqueous components in addition to water. From the viewpoint of transparency, the proportion of (c) water in the aqueous component is preferably 60% by mass or more, more preferably 70% by mass, and even more preferably 80% by mass or more.
  • the mass ratio of (a) cholesterol and (c) water ((a) cholesterol:(c) water) is preferably 0.1:99.9 to 3:97 from the viewpoint of transparency and stability. 0.1:99.9 to 2:98 is more preferred, and 0.1:99.9 to 1.5:98.5 is even more preferred.
  • the main component of the transparent aqueous composition is water, which is liquid.
  • the transparent aqueous composition may contain a polyol.
  • Polyols are amphiphilic, and the inclusion of polyols improves the dispersibility of cholesterol in water, which can improve the transparency of the composition.
  • the polyol is not particularly limited as long as it is commonly used in cosmetics. For example, propylene glycol, dipropylene glycol, 1,3-propanediol, 1,3-butylene glycol, isopentyldiol, pentylene glycol, hexanediol, caprylyl glycol, glycerin, diglycerin, polyglycerin, polyethylene glycol, poly and oxyethylene methyl glucoside.
  • dihydric alcohols such as propylene glycol, 1,3-propanediol, 1,3-butylene glycol, pentylene glycol and hexanediol are preferable from the viewpoint of improving transparency.
  • Polyols may be used singly or in combination of two or more.
  • the content of the polyol is not particularly limited, but from the viewpoint of transparency and stability, it is preferably 0.1% by mass or more, more preferably 1% by mass or more, and more preferably 3% by mass or more. .
  • the upper limit is not particularly limited, for example, it is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less.
  • the water content in the transparent aqueous composition is preferably 60 to 95% by mass, more preferably 70 to 95% by mass, and even more preferably 80 to 95% by mass, relative to the total amount of the composition. .
  • the transparent aqueous composition may contain oily components other than cholesterol.
  • the oily component means a component generally used as an oily component in the field of cosmetics.
  • the solubility in water at 25° C. is less than 0.1% by mass (less than 1 g/L).
  • the oily component does not include surfactants (above (b) surfactants having a sterol skeleton and (e2) other surfactants described later).
  • the clear aqueous composition is substantially free of oily components (such as water-insoluble solvents) other than cholesterol. In some embodiments, the clear aqueous composition does not contain oily components other than cholesterol. Transparency and stability can be improved by using a composition containing little or no oil component other than cholesterol.
  • Oily components other than cholesterol are not particularly limited, but include higher monoalcohols, hydrocarbons, ester oils, fats and oils, fatty acids, waxes, and silicone oils. These may be used individually by 1 type, and may be used in combination of 2 or more types.
  • the higher monoalcohol is not particularly limited, but is preferably linear, more preferably linear with 12 to 22 carbon atoms (more preferably with 14 to 22 carbon atoms, still more preferably with 16 to 22 carbon atoms). ) is a higher monoalcohol. Specific examples include cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol, and the like.
  • the hydrocarbon is not particularly limited, and examples thereof include liquid paraffin, squalane, ⁇ -olefin oligomer, petrolatum, microcrystalline wax, and the like.
  • Ester oils are not particularly limited, and examples include cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-hexyldecyl 2-ethylhexanoate, 2-octyldodecyl myristate, 2-hexyldecyl myristate, and isononane.
  • Fats and oils are not particularly limited, and examples thereof include olive oil, shea butter, grape seed oil and the like.
  • the wax is not particularly limited, and examples thereof include jojoba oil, beeswax, candelilla wax and the like.
  • Fatty acids are not particularly limited and include, for example, myristic acid, palmitic acid, stearic acid and the like.
  • the transparent aqueous composition does not contain higher monoalcohols.
  • the clear aqueous composition is free of hydrocarbons.
  • the clear aqueous composition is free of ester oils.
  • the clear aqueous composition is fat-free.
  • the clear aqueous composition does not contain fatty acids.
  • the clear aqueous composition is wax-free.
  • the clear aqueous composition is free of silicone oil.
  • the transparent aqueous composition may optionally contain (b) a surfactant other than the surfactant having a sterol skeleton (other surfactants).
  • a surfactant other than the surfactant having a sterol skeleton other surfactants.
  • Other surfactants include, but are not limited to, alkyl ether surfactants such as polyoxyethylene alkyl ethers and polyoxyethylene polyoxypropylene alkyl ethers; polyoxyethylene fatty acid esters; polyoxyethylene sorbitan fatty acid esters.
  • sorbitan fatty acid esters such as sorbitan monopalmitate; polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil isostearate, polyoxyethylene sorbitol tetra fatty acid ester, polyoxyethylene phytosterol, lipophilic Glycerin fatty acid esters such as glyceryl monostearate and tetraglyceryl monostearate, glycerin fatty acid esters such as polyglycerin fatty acid esters, sucrose fatty acid esters, polyethylene glycol distearate, etc. may be used alone. , may be used in combination of two or more. Among these, at least one of sorbitan monopalmitate, lipophilic glyceryl monostearate, and tetraglyceryl monostearate is preferably used.
  • the content of other surfactants is not particularly limited, but from the viewpoint of transparency and stability, it is preferably 0 to 3% by mass, more preferably 0 to 1% by mass, based on the total amount of the composition.
  • the clear aqueous composition does not contain other surfactants.
  • the transparent aqueous composition may contain aqueous components other than (c) water and (d) polyol.
  • the aqueous component forms the outer phase of the composition.
  • aqueous components examples include wetting agents, natural polymers, synthetic polymers, preservatives, and lower monoalcohols. These may be used individually by 1 type, and may be used in combination of 2 or more types.
  • the aqueous component does not include surfactants (above (b) surfactants having a sterol skeleton and (e2) other surfactants).
  • Wetting agents include, but are not limited to, sugars such as sorbitol, mannitol, glucose, xylitol, maltitol, and trehalose, arginine, proline, serine, lysine HCl, threonine, valine, leucine, histidine, alanine, glycine, carnosine, and the like. amino acids, sodium pyrrolidonecarboxylate, betaine, urea, sodium lactate, plant extracts, seaweed extracts and the like can be used.
  • the aqueous component is not particularly limited, but natural polymers such as guar gum, carrageenan, xanthan gum, sodium hyaluronate, pullulan, agar, alginate, hydroxyethyl cellulose, hydroxymethyl cellulose, carboxyvinyl polymer, and polyacrylate. , polyvinyl alcohol, synthetic polymers such as acrylic acid-alkyl methacrylate copolymer, preservatives, and the like may also be used.
  • a lower monoalcohol may be included as an aqueous component.
  • lower monoalcohols include primary alcohols having 1 to 5 carbon atoms, preferably ethanol.
  • the content of the lower monoalcohol as the aqueous component should be as small as possible from the viewpoint of safety.
  • the content of the lower monoalcohol is preferably 0 to 5% by mass, more preferably 0 to 3% by mass, still more preferably 0 to 1% by mass, relative to the total amount of the composition.
  • the clear aqueous composition is free of lower monoalcohols.
  • the mass ratio of the lower monoalcohol to (c) water (lower monoalcohol/water) is preferably 0.3 or less.
  • the mass ratio (lower monoalcohol/water) is more preferably 0.2 or less, still more preferably 0.1 or less.
  • a transparent aqueous composition may be prepared by selecting raw materials as necessary.
  • the transparent aqueous composition may contain optional ingredients contained in ordinary cosmetics, quasi-drugs, or pharmaceuticals.
  • moisturizing agents, antioxidants, ultraviolet absorbers, thickeners, pH adjusters, powder components, sequestering agents, colorants, various skin nutrients and drugs, etc. may be appropriately contained as necessary. can.
  • a transparent aqueous composition can be produced according to a conventional method.
  • (a) cholesterol, and optionally (d) polyol, (e1) an oily component containing other oily components, (b) a surfactant having a sterol skeleton, and optionally (e2 ) a surfactant containing other surfactants, (c) water, and optionally (e3) an aqueous component containing other aqueous components are stirred and mixed in an appropriate order, and if necessary Heat and homogenize.
  • the transparent aqueous composition of the present invention can also be made into various dosage forms. Specific examples include, but are not limited to, mists, sprays, lotions, and the like.
  • the transparent aqueous composition can be used as a cosmetic.
  • a cosmetic for example, lotion, milky lotion, cream, serum, massage agent, mask, hand cream, body lotion, body cream, skin care cosmetics such as sunscreen, foundation, eye shadow, eyeliner, mascara, eyebrow, concealer, lipstick , finishing cosmetics such as lip balms, hair cosmetics such as hair mists, treatments, hair creams, hair shampoos and hair rinses.
  • skin care cosmetics such as sunscreen, foundation, eye shadow, eyeliner, mascara, eyebrow, concealer, lipstick
  • finishing cosmetics such as lip balms
  • hair cosmetics such as hair mists, treatments, hair creams, hair shampoos and hair rinses.
  • the method of use include a method of using hands, fingers, cotton, and a method of impregnating a non-woven fabric or the like.
  • the transparent aqueous composition of the present invention is also suitably used for quasi-drugs, pharmaceuticals and the like.
  • the transparent aqueous composition can also be used as an external skin preparation. Examples include external liquids, external gels, creams, ointments, liniments, lotions, poultices, plasters, sprays, aerosols, and the like.
  • the method of use thereof is the same as that of the cosmetics described above.
  • the transparent aqueous composition of the present invention has excellent transparency.
  • the transparent aqueous composition has a transmittance of 20% or more (preferably 40% or more, more preferably 60% or more, still more preferably 80% or more, and particularly preferably 95% or more) at a wavelength of 700 nm.
  • the clear aqueous composition is free of haze and sediment. In some embodiments, the clear aqueous composition is solubilized.
  • the transparent aqueous composition of the present invention has excellent stability.
  • the transparent aqueous composition is free from white turbidity and sediment after being left at room temperature (for example, 20 to 30° C., especially 25° C.) for one month after preparation.
  • the clear aqueous composition is solubilized.
  • “solubilized” refers to the state of microemulsion.
  • the transparent aqueous composition is solubilized, defined herein as having a transmittance of 95% or greater for light at a wavelength of 700 nm.
  • compositions having compositions shown in Tables 1 to 6 were prepared by the following procedure. First, components other than purified water (cholesterol, surfactant, polyol) were mixed and heated to 85° C. to dissolve cholesterol in the solution. Purified water heated to 85° C. was added to this, and the mixture was cooled to 35° C. while stirring with a stirrer to obtain a cosmetic composition.
  • purified water cholesterol, surfactant, polyol
  • Surfactant having a sterol skeleton ⁇ EMALEX CS-15 (manufactured by Nippon Emulsion Co., Ltd.): Polyoxyethylene (POE15) cholesteryl ether (HLB: 11) ⁇ EMALEX CS-20 (manufactured by Nippon Emulsion Co., Ltd.): polyoxyethylene (POE20) cholesteryl ether (HLB: 12) ⁇ EMALEX CS-24 (manufactured by Nippon Emulsion Co., Ltd.): polyoxyethylene (POE24) cholesteryl ether (HLB: 13) 2.
  • NIKKOL HCO-40 manufactured by Nikko Chemicals Co., Ltd.
  • POE 40
  • HLB hydrogenated castor oil
  • Decaglyn 1-ISV manufactured by Nikko Chemicals Co., Ltd.
  • polyglyceryl isostearate-10 HLB: 12
  • compositions of the example yields a composition having excellent transparency. Furthermore, the compositions of these examples did not have cholesterol sediments and were excellent in stability (evaluation of stability: C or higher).
  • the compositions of Examples, in which the (b) surfactant is blended at a (b)/(a) ratio of 5 or more achieve high transparency, suppress or reduce white turbidity, and maintain stability. was excellent.
  • a transparent liquid containing 0.1 to 2.0% by mass of cholesterol can be obtained by blending a surfactant having a sterol skeleton (EMALEX CS-20) together with cholesterol.
  • EMALEX CS-20 a surfactant having a sterol skeleton
  • the compositions of Examples containing 0.1 to 1.0% by mass of cholesterol exhibited high transparency and excellent stability.
  • the white turbidity tended to become stronger. is 4 or more, more preferably 5 or more), it was confirmed that cholesterol can be stably dispersed in water.
  • composition having 15 to 24 added moles of polyoxyethylene in the (b) surfactant having a sterol skeleton was excellent in transparency and stability.
  • the composition in which the number of added moles of polyoxyethylene was 20 was particularly excellent in transparency and stability.
  • the transparent aqueous composition of the present invention has excellent transparency while containing cholesterol in the aqueous phase, and can be suitably used, for example, as cosmetics and external preparations for skin.

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Abstract

L'invention vise à fournir une composition exceptionnellement transparente dans laquelle le cholestérol peut être dispersé de manière stable dans un milieu aqueux.　L'invention concerne une composition aqueuse transparente contenant (a) du cholestérol, (b) un tensioactif ayant un squelette stérol, et (c) de l'eau, le rapport massique ((b) tensioactif ayant un squelette stérol/(a) cholestérol) du (b) tensioactif ayant un squelette stérol au (a) cholestérol étant supérieur ou égal à 4.
PCT/JP2023/005089 2022-02-16 2023-02-15 Composition aqueuse transparente WO2023157851A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011195461A (ja) * 2010-03-17 2011-10-06 Nikko Chemical Co Ltd ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物
JP2013227294A (ja) * 2012-03-30 2013-11-07 Kose Corp 半透明性乃至透明性組成物
WO2017090740A1 (fr) * 2015-11-26 2017-06-01 株式会社コーセー Composition contenant une structure bicellulaire
WO2018061854A1 (fr) * 2016-09-28 2018-04-05 株式会社マンダム Composition pour produit cosmétique
JP2020002113A (ja) * 2018-07-02 2020-01-09 日本メナード化粧品株式会社 透明組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011195461A (ja) * 2010-03-17 2011-10-06 Nikko Chemical Co Ltd ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物
JP2013227294A (ja) * 2012-03-30 2013-11-07 Kose Corp 半透明性乃至透明性組成物
WO2017090740A1 (fr) * 2015-11-26 2017-06-01 株式会社コーセー Composition contenant une structure bicellulaire
WO2018061854A1 (fr) * 2016-09-28 2018-04-05 株式会社マンダム Composition pour produit cosmétique
JP2020002113A (ja) * 2018-07-02 2020-01-09 日本メナード化粧品株式会社 透明組成物

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