WO2023151496A1

WO2023151496A1 - Nerve stimulation electrode, nerve stimulation device and nerve stimulation system

Info

Publication number: WO2023151496A1
Application number: PCT/CN2023/074138
Authority: WO
Inventors: 姜传江
Original assignee: 苏州景昱医疗器械有限公司
Priority date: 2022-02-11
Filing date: 2023-02-01
Publication date: 2023-08-17
Also published as: CN114534094A

Abstract

The present application provides a nerve stimulation electrode, a nerve stimulation device and a nerve stimulation system. The nerve stimulation electrode comprises: an electrode housing comprising a hollow tube and a stimulation head end, the simulation head end being disposed inside the electrode housing and being used for conducting electrical stimulation energy to the surface of tissue so as to electrically stimulate the tissue and collecting electric signals of the tissue, wherein the stimulation head end can move in the electrode housing in an axial direction of the electrode housing, and/or the stimulation head end can rotate in the electrode housing in a circumferential direction of the electrode housing. According to the nerve stimulation electrode of the present application, electrical stimulation can be carried out on different parts of the organism tissue by using fewer stimulation contacts, and accurate stimulation is realized by collecting and analyzing the electric signals of the different parts.

Description

Neurostimulation electrodes, neurostimulation devices and neurostimulation systems

This application claims the priority of the Chinese patent with application number 202210130156.6 filed on February 11, 2022, which is incorporated by reference in its entirety.

technical field

The present application relates to the field of implantable medical devices, such as nerve stimulation electrodes, nerve stimulation devices and nerve stimulation systems.

Background technique

The neurostimulation electrodes of related interventional neurostimulation devices usually have multiple fixed stimulation contacts. During the operation, the medical staff implants the electrodes into a specific area in the tissue such as the brain according to the existing knowledge and experience of the specific disease. , so as to electrically stimulate the tissue, so as to achieve the purpose of treating certain diseases. Usually, in order to obtain a better combination of stimulation directions and points, stimulation contacts will be preset as many as possible, for example, 8 contacts, 12 contacts, 24 contacts, etc., and correspondingly set for each stimulation contact Wires are connected to deliver electrical stimulation energy. However, due to the small space in the nerve stimulation electrodes, it is difficult to set too many stimulation contacts and corresponding lines, and thus limits the flexibility of the doctor's identification of disease sites and theoretical research and treatment of more stimulation contact sites .

Contents of the invention

The purpose of this application is to provide nerve stimulation electrodes, nerve stimulation devices and nerve stimulation systems. The nerve stimulation electrodes can use fewer stimulation contacts to achieve electrical stimulation to different parts of biological tissues, and collect and analyze electrical signals from different parts. signal to achieve precise stimulation.

The purpose of this application adopts following technical scheme to realize:

In a first aspect, the present application provides a nerve stimulation electrode, and the nerve stimulation electrode includes:

an electrode housing which is a hollow tube, and

a stimulating tip, the stimulating tip is arranged inside the electrode housing, and the stimulating tip is used to conduct electrical stimulation energy to the surface of the tissue to electrically stimulate the tissue, and collect electrical signals of the tissue,

Wherein, the stimulating tip can move in the electrode housing along the axial direction of the electrode housing, and/or, the stimulating tip can rotate in the electrode housing along the circumferential direction of the electrode housing.

In a possible implementation manner, the nerve stimulation electrode further includes a shaft part, and the shaft part is set inside the electrode housing and extending axially of the electrode housing,

Wherein, the stimulating head end is connected with the shaft component and can rotate around the axial direction of the electrode housing, so that the stimulating head end can rotate along the circumferential direction of the electrode housing.

In a possible implementation manner, the stimulation head end includes:

stimulation contacts for conducting electrical stimulation energy to a tissue surface to electrically stimulate said tissue, and

A signal collection contact, which is used to collect the electrical signal.

In a possible implementation manner, the shape of the stimulation contact is one or more of ellipse, circle, rounded rectangle, rectangle, triangle and ring.

In a possible implementation manner, the number of the stimulating head end is greater than one.

In a possible implementation manner, the electrode casing includes a honeycomb insulating part and a plurality of conductive parts separated by the insulating part, any two conductive parts are kept insulated, and at least two The stimulation tips are respectively in contact with different conductive parts.

In a possible implementation manner, the electrode shell includes a honeycomb insulating part and a plurality of semiconductor parts separated by the insulating part, any two semiconductor parts are kept insulated, and each semiconductor part has a control end, a first connection end and a second connection end, the first connection end of each semiconductor part is connected to the signal transmission end to conduct the electrical stimulation energy or collect the electrical signal, and the second connection end of each semiconductor part extends to said organization;

There are at least two stimulating head terminals respectively contacting the control terminals of different semiconductor parts for turning on and off the first connection terminal and the second connection terminal of the contacted semiconductor parts.

In a possible implementation, the types of diseases that the nerve stimulation electrodes are used for treatment include epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, autism and drug addiction one or more of .

In a second aspect, the present application provides a nerve stimulation device, which includes at least one nerve stimulation electrode described in any one of the foregoing.

In a possible implementation manner, the nerve stimulation device further includes a driving unit, and the driving unit is used to drive the stimulation head end to move along the axial direction of the electrode casing and to move along the circumference of the electrode casing. to rotate.

In a possible implementation manner, the nerve stimulation device further includes a control unit, and the control unit The unit is used for analyzing the electrical signal and moving the stimulating head end according to the analysis result of the electrical signal, so as to realize precise stimulation.

In a third aspect, the present application provides a nerve stimulation system, and the nerve stimulation system includes any one of the above nerve stimulation devices.

The use of the nerve stimulation electrode, nerve stimulation device and nerve stimulation system for household medical equipment provided by the present application has at least the following advantages: electrical stimulation to different parts of biological tissues can be realized with fewer stimulation heads.

Description of drawings

The application will be further described below in conjunction with the accompanying drawings and embodiments.

Fig. 1 is a schematic structural diagram of a nerve stimulation electrode provided by an embodiment of the present application;

Fig. 2 is a perspective view of a stimulating head end and shaft parts provided by the embodiment of the present application;

Fig. 3 is a schematic structural diagram of a stimulation head end provided by an embodiment of the present application;

Fig. 4 is a perspective view of another stimulation head and shaft parts provided by the embodiment of the present application;

Fig. 5 is a perspective view of another stimulation head end and shaft components provided by the embodiment of the present application;

Fig. 6 is a perspective view of another stimulation head end and shaft parts provided by the embodiment of the present application;

Fig. 7 is a perspective view of another stimulation head end and shaft parts provided by the embodiment of the present application;

Fig. 8 is a schematic structural view of an electrode casing provided in an embodiment of the present application;

Fig. 9 is a schematic structural view of another electrode casing provided by the embodiment of the present application;

Fig. 10 is a schematic structural diagram of a nerve stimulation device provided by an embodiment of the present application;

Fig. 11 is a schematic structural diagram of a sliced electrode provided in the related art.

In the figure: 1, nerve stimulation device; 10, nerve stimulation electrode; 101, electrode shell; 1011, insulating part; 1012, conductive part; 1013, semiconductor part; 102, stimulating head; 1021, stimulating contact; Signal acquisition contacts; 103, shaft components; 11, drive unit; 12, energy supply unit; 13, control unit.

Detailed ways

Below, the present application will be further described in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, on the premise of not conflicting, the various embodiments described below or the technical features can be combined arbitrarily to form a new embodiment. .

In the following, one of the application fields (namely, implantable neurostimulator) of the embodiment of the present application will be briefly described first.

An implantable neurostimulator system (a neurostimulation system) mainly includes a stimulator implanted in a patient (ie, an implanted neurostimulator, a neurostimulation device) and a program-controlled device placed outside the patient's body. The related neuromodulation technology mainly uses stereotaxic surgery to implant electrodes in specific parts of the organism's tissues (ie, targets), and the stimulator implanted in the patient's body sends electrical pulses to the targets through the electrodes to regulate the corresponding neural structures. And network electrical activity and its function, thereby improving symptoms and relieving pain. Among them, the stimulator can be an implantable electrical nerve stimulation device, an implantable cardiac electrical stimulation system (also known as a cardiac pacemaker), an implantable drug infusion device (Implantable Drug Delivery System, referred to as IDDS) and a wire switch. any one of the connected devices. Implantable electrical nerve stimulation devices are, for example, Deep Brain Stimulation (DBS), Implantable Cortical Nerve Stimulation (CNS), Implantable Spinal Cord Stimulation , referred to as SCS), implanted sacral nerve stimulation system (Sacral Nerve Stimulation, referred to as SNS), implanted vagus nerve stimulation system (Vagus Nerve Stimulation, referred to as VNS), etc.

The stimulator can include IPG, extension wires and electrode wires. IPG (implantable pulse generator, implantable pulse generator) is set in the patient's body, receives program-controlled instructions sent by the program-controlled device, and relies on sealed batteries and circuits to provide controllable pulses to tissues in the body. The electrical stimulation energy, through the implanted extension lead and electrode lead, delivers one or two controllable specific electrical stimulations to specific areas of tissues in the body. The extension wire is used in conjunction with the IPG as a transmission medium for the electrical stimulation signal, and transmits the electrical stimulation signal generated by the IPG to the electrode wire. The electrode leads may be neurostimulation electrodes that deliver electrical stimulation to specific regions of tissue in the body through multiple electrode contacts. The stimulator is provided with one or more electrode wires on one side or both sides, and a plurality of electrode contacts are arranged on the electrode wires, and the electrode contacts can be arranged uniformly or non-uniformly in the circumferential direction of the electrode wires. As an example, the electrode contacts may be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) in the circumferential direction of the electrode wire. Electrode contacts may include stimulation contacts and/or collection contacts. The electrode contacts can be in the shape of, for example, a sheet, a ring, or a dot.

In some possible ways, the stimulated body tissue can be the patient's brain tissue, and the stimulated site can be a specific part of the brain tissue. When the patient's disease type is different, the stimulated site is generally different, the number of stimulation contacts (single source or multi-source) used, one or more channels (single-channel or multi-channel) specific electrical stimulation signals The application and stimulus parameter data are also different. The embodiment of this application is suitable for The type of disease used is not limited, and it may be the type of disease applicable to deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. Among the types of disorders that DBS can be used to treat or manage include, but are not limited to: spasticity disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety disorders, Post-traumatic stress disorder, hypodepression, obsessive-compulsive disorder (OCD), conduct disorder, mood disorder, memory disorder, mental status disorder, mobility disorder (eg, essential tremor or Parkinson's disease), Huntington's disease, Al Alzheimer's disease, drug addiction, autism, or other neurological or psychiatric conditions and impairments.

In the embodiment of the present application, when the program-controlled device and the stimulator establish a program-controlled connection, the program-controlled device can be used to adjust the stimulation parameters of the stimulator (different stimulation parameters correspond to different electrical stimulation signals), and the stimulator can also be used to sense the deep brain of the patient. The bioelectric activity of the stimulator can be used to collect the electrophysiological signal, and the stimulation parameters of the electrical stimulation signal of the stimulator can be adjusted continuously through the collected electrophysiological signal.

Stimulation parameters can include: frequency (for example, the number of electrical stimulation pulse signals per unit time 1s, unit is Hz), pulse width (duration of each pulse, unit is μs), amplitude (generally expressed by voltage, that is, The intensity of each pulse, the unit is V), timing (for example, it can be continuous or triggered), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cycle stimulation mode), doctor's control upper limit One or more of upper and lower limits (range adjustable by doctors) and upper and lower limits of patient control (range adjustable by patients).

In a specific application scenario, various stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

The program-controlled device may be a doctor-programmed device (ie, a program-controlled device used by a doctor) or a patient-programmed device (ie, a program-controlled device used by a patient). The doctor's program-controlled device can be, for example, a tablet computer, a notebook computer, a desktop computer, a mobile phone and other smart terminal devices equipped with program-controlled software. The patient program-controlled device can be, for example, smart terminal devices such as tablet computers, notebook computers, desktop computers, and mobile phones equipped with program-controlled software, and the patient program-controlled device can also be other electronic devices with program-controlled functions (such as chargers with program-controlled functions, data collection device).

The embodiment of the present application does not limit the data interaction between the doctor's program-controlled device and the stimulator. When the doctor remotely programs, the doctor's program-controlled device can perform data interaction with the stimulator through the server and the patient's program-controlled device. When the doctor performs program control with the patient face-to-face offline, the doctor’s program-controlled device can interact with the stimulator through the patient’s program-controlled device, and the doctor’s program-controlled device can also directly interact with the stimulator.

In some possible ways, the patient programmable device may include a host (communicating with the server) and a slave (communicating with the stimulator), the host and slave being communicatively connected. Among them, the doctor's program-controlled equipment can exchange data with the server through the 3G/4G/5G network, the server can exchange data with the host through the 3G/4G/5G network, and the host can exchange data with the slave through the Bluetooth protocol/WIFI protocol/USB protocol. Interaction, the sub-machine can exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band, and the doctor's program-controlled equipment can directly exchange data with the stimulator through the 401MHz-406MHz working frequency band/2.4GHz-2.48GHz working frequency band interact.

Referring to FIG. 1 and FIG. 2, FIG. 1 shows a schematic structural diagram of a nerve stimulation electrode 10 provided in an embodiment of the present application, and FIG. 2 shows a structure of a stimulating head end 102 and a shaft part 103 provided in an embodiment of the present application. stereogram. The embodiment of the present application provides a nerve stimulation electrode 10, the nerve stimulation electrode 10 includes:

An electrode casing 101, which is a hollow tube, and

Stimulation head end 102, the stimulation head end 102 is arranged inside the electrode housing 101, and the stimulation head end 102 is used to conduct electrical stimulation energy to the tissue surface to electrically stimulate the tissue, and collect the tissue pair electrical signal,

Wherein, the stimulating head end 102 can move in the electrode housing 101 along the axial direction of the electrode housing 101, and/or, the stimulating head end 102 can move along the electrode housing 101 in the electrode housing 101 101 circumferential rotations.

As shown in FIG. 1 , in some possible manners, the nerve stimulation electrode 10 includes an electrode housing 101 and a stimulation tip 102 . The electrode casing 101 is a hollow tube, and the stimulating tip 102 is accommodated inside the electrode casing 101 . There is no specific limitation on the material of the electrode casing 101, and materials commonly used in this field can be used. In a specific application, the electrode housing 101 may be a flexible elongated hollow tube.

In some possible ways, the stimulation head end 102 is connected to the energy supply unit 12 (described in detail below) through a wire, and is used to apply the electrical stimulation energy from the energy supply unit 12 to a specific part of the tissue of the living body, so as to realize Electrical stimulation of specific parts of the tissue (also sometimes referred to herein as "neural stimulation"). At the same time, the stimulating head end 102 can also collect electrical signals of tissues in the living body. When the stimulated tissue is brain tissue, such electrical signals are, for example, electroencephalogram signals. The embodiment of the present application does not limit the generated electrical signal, which can be a single-cell electrical signal generated by a single cell (electrical changes at the neuron level), or a local field potential (electrical changes at the central level such as the nuclei level). Variety).

This application does not limit the type of organism, which can be human, or monkey, rabbit, cat, Dogs and other animals.

In some possible ways, the stimulation tip 102 can move inside the electrode housing 101 . There is no particular limitation on the specific way in which the stimulating head end 102 moves inside the electrode housing 101, for example, the stimulating head end 102 can move (translate) along the axial direction of the electrode housing 101, or the stimulating head end 102 can move along the circumferential direction of the electrode housing 101 Rotate (rotate to move). In some possible ways, the stimulating head end 102 can rotate 360 degrees along the circumference of the electrode shell 101, and the control precision of the rotation angle can be millimeter, micron or nanometer level, so as to achieve a smooth, Continuous adjustment function. Through the translational and rotational movement of the stimulating head end 102 , a small number of stimulating head ends 102 can respectively stimulate different parts of the biological tissue and collect electrical signals of these parts.

In some possible ways, as shown in FIGS. 1 and 2 , the nerve stimulation electrode 10 further includes a shaft part 103 . The shaft member 103 is disposed inside the electrode casing 101 and extends along the axial direction of the electrode casing 101 . In some possible ways, the shaft member 103 is set to coincide with the central axis of the electrode casing 101 . In some possible ways, the stimulation head 102 is connected with the shaft part 103 to rotate around the axis of the electrode housing 101 (for example, the central axis of the shaft part 103 itself), so as to realize the circumferential rotation of the electrode housing 101 . The material of the shaft member 103 is not particularly limited.

The present application does not limit the ways in which the stimulating head end 102 conducts electrical stimulation energy and collects electrical signals, which can be realized by the same set of electrodes or by two sets of electrodes set separately. As used herein, a single electrode can conduct electrical stimulation energy and/or acquire electrical signals. The electrical signal collected may be a single cell EEG signal, or a local field potential (LFP) EEG signal, or may include the above two signals at the same time.

Referring to FIG. 3 , FIG. 3 shows a schematic structural diagram of a stimulation head end 102 provided by an embodiment of the present application. In some possible ways, the stimulation head end 102 may include a stimulation contact 1021 and a signal collection contact 1022 . There is no particular limitation on the specific materials of the stimulation contacts 1021 and the signal collection contacts 1022 . Specifically, in some possible manners, the stimulating contact 1021 is used to conduct electrical stimulation energy to the surface of the tissue to electrically stimulate the tissue, while the signal collection contact 1022 is used to collect electrical signals of tissues in the body.

Referring to Fig. 4 and Fig. 5, Fig. 4 shows a perspective view of another stimulating head end 102 and a shaft part 103 provided in the embodiment of the present application, and Fig. 5 shows another stimulating head end 102 provided in the embodiment of the present application and a perspective view of the shaft member 103. It can be seen that, in FIG. 4 , two stimulating head ends 102 are arranged on the shaft component 103 , and the angle between the two stimulating head ends 102 is 60 degrees. In some other possible ways, when the shaft part 103 When two stimulation heads 102 are provided, the included angle between them may be 15 degrees, 30 degrees, 45 degrees, 90 degrees, 120 degrees, 180 degrees, etc., which is not limited in this embodiment of the present application. In FIG. 5, there are 15 stimulating head-ends 102, and the 15 stimulating head-ends 102 are arranged in a circular array of 5 rows and 3 columns. The embodiment of the present application does not limit the arrangement of the plurality of stimulating head ends 102 , which may be evenly distributed on the shaft member 103 or unevenly distributed.

As mentioned above, in some possible manners of the present application, the number of stimulating head-ends 102 may be one, and in other possible manners, the number of stimulating head-ends 102 may be greater than one. Each stimulating tip 102 may be provided with one stimulating contact 1021 , or each stimulating tip 102 may be provided with more than one stimulating contact 1021 that is insulated from each other. There is no particular limitation on the specific number of total stimulation contacts 1021 , and the number is, for example, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36 and so on. The specific shape of the stimulation contact 1021 is not particularly limited, for example, it may be one or more of oval, circular, rounded rectangle, rectangle, triangle and ring. In addition, there is no particular limitation on the specific shape of the signal collection contact 1022 .

In a practical application, the number of signal collection contacts 1022 is the same as the number of stimulation contacts 1021 , and each signal collection contact 1022 is set at the center of the stimulation contact 1021 in a one-to-one correspondence.

It should be noted that the signal collection contacts 1022 and the stimulation contacts 1021 are insulated from each other, that is, in the embodiment of the present application, any two signal collection contacts 1022 are insulated from each other, and any two stimulation contacts 1021 are insulated from each other. The contacts 1021 are insulated from each other, and any signal collection contact 1022 and any stimulation contact 1021 are insulated from each other.

Referring to FIG. 6 , FIG. 6 shows a perspective view of another stimulation head end 102 and shaft component 103 provided by the embodiment of the present application. Wherein, the number of stimulating head-ends 102 is 8, each stimulating head-end 102 is provided with 1 stimulating contact 1021 and 1 signal collecting contact 1022, like this, the quantity of signal collecting contact 1022 and stimulating contact 1021 The quantity is 8. The stimulation contacts 1021 form four ring structures with the same diameter arranged in sequence along the axial direction, the first and last ring structures are composed of a ring electrode, and the middle two ring structures are respectively arranged at intervals along the circumference of the electrode housing 101 It consists of 3 sliced electrodes (located on the 3 stimulating head ends 102 respectively). At this time, the stimulating tip 102 may be in a shape corresponding to the stimulating contact 1021 , such as a ring shape.

Referring to FIG. 6 and FIG. 7 , FIG. 7 shows a perspective view of another stimulation head end 102 and shaft component 103 provided by the embodiment of the present application. When the shape of the stimulating head end 102 is ring-shaped, the connection part between it and the shaft part 103 One (as shown in FIG. 6 ) may be provided, or multiple (as shown in FIG. 7 , a plurality of connecting parts are arranged in a structure uniformly distributed along the circumference of the electrode casing 101), when multiple When there are two connecting parts evenly distributed along the circumference of the electrode shell 101, the shaft member 103 can be prevented from being deformed due to uneven force, thereby improving the service life of the entire nerve stimulation electrode 10.

Referring to FIG. 8 , FIG. 8 shows a schematic structural diagram of an electrode casing 101 provided by an embodiment of the present application. In a possible implementation manner, the electrode casing 101 includes a honeycomb insulating portion 1011 and a plurality of conductive portions 1012 separated by the insulating portion 1011, and insulation between any two conductive portions 1012 is maintained. , at least two stimulating head ends 102 are in contact with different conductive parts 1012 respectively.

It should be noted that the cellular shape in the embodiment of the present application refers to the porous shape, and the application does not limit the number, shape, and size of the holes, and the number of holes can be 3, 5, 8, 16, 24 pcs, 32 pcs, 100 pcs, 1000 pcs, 10000 pcs, etc. The shape of each hole can be circular as shown in Figure 8, or oval, rounded rectangle, rectangle, triangle, ring, regular pentagon , regular hexagon, regular octagon, etc., the shapes of the multiple holes may be the same or different.

A plurality of conductive parts 1012 are disposed in a plurality of holes of the honeycomb insulating part 1011, and the number of the conductive parts 1012 may be the same as the number of holes. The electrode shell 101 can form a relatively airtight environment, which isolates the contact between the internal tissues of the living body and the stimulation head 102 .

The present application does not limit the material of the insulating part 1011 and the conductive part 1012. The material of the insulating part 1011 is, for example, parylene or other silicon-based materials, and the material of the conductive part 1012 is, for example, copper, tin, silver, gold and platinum. one or more of.

Thus, the honeycomb-shaped insulating part 1011 is set to provide mutual insulation conditions for a plurality of conductive parts 1012, and at least two stimulating head ends 102 are respectively contacted with different conductive parts 1012 to realize the wire function (conduction) of a traditional nerve stimulation electrode. Electrical stimulation, transmission of collected electrical signals), compared with traditional nerve stimulation electrodes that need to use multiple wires to realize the interactive function between multiple electrodes and pulse generators, only the movable stimulation head 102 is required to be fixed The provided electrode casing 101 can play an interactive role, avoiding a sharp increase in process cost and maintenance cost caused by too many wires. Each stimulating head end 102 is connected to the pulse generator respectively, and the stimulating head end 102 can reach any position during use (the conduction between the stimulating head ends 102 is realized through the corresponding conductive part 1012), so that the doctor can control the internal tissue of the patient. The various parts of the body need to be stimulated and collected.

Referring to Fig. 9, Fig. 9 shows a schematic structural view of another electrode housing 101 provided by the embodiment of the present application picture. In a possible implementation manner, the electrode shell 101 includes a honeycomb insulating portion 1011 and a plurality of semiconductor portions 1013 separated by the insulating portion 1011, any two semiconductor portions 1013 are kept insulated, each Each semiconductor part 1013 has a control terminal, a first connection terminal and a second connection terminal, the first connection terminal of each semiconductor part 1013 is connected to the signal transmission terminal to conduct the electrical stimulation energy or collect the electrical signal, each semiconductor the second connection end of portion 1013 extends to the tissue;

At least two stimulating head terminals 102 are respectively in contact with the control terminals of different semiconductor parts 1013 for turning on and off the first connection terminal and the second connection terminal of the semiconductor part 1013 they contact.

A semiconductor is a material whose conductivity is between a conductor and an insulator at room temperature. Common semiconductor materials include silicon (Si), germanium (Ge), compound semiconductors such as gallium arsenide (Gas), etc., doped or made into other compound semiconductors Materials such as boron (B), phosphorus (P), indium (In) and antimony (Sb), etc. Silicon is the most commonly used semiconductor material. Semiconductors usually have the following characteristics:

1. The conductivity of semiconductors is between that of conductors and insulators;

2. When the semiconductor is stimulated by external light and heat, its conductivity will change significantly;

3. In a pure semiconductor, adding a small amount of impurities will sharply increase its conductivity.

The application does not limit the components selected for the semiconductor part 1013, which may be a single transistor, MOS transistor, JFET, etc., or a circuit including a transistor, MOS transistor or JFET. MOS tube, that is, Metal-Oxide Semiconductor Field-Effect Transistor, referred to as Metal-Oxi de-Semiconductor Field-Effect Transistor (MOSFET). JFET refers to the junction field effect transistor (Junction Field-Effect Transistor, JFET). For a triode, the control terminal can be its base, and the first connection terminal and the second connection terminal can be its emitter and collector; for MOS tubes and JFETs, the control terminal can be its gate, and the first connection terminal and the second connection terminal may be its source and drain. For the various semiconductor parts 1013 mentioned above, the first connection terminal and the second connection terminal can be turned on and off by inputting different electrical signals to their control terminals.

Thus, the honeycomb-shaped insulating part 1011 is set to provide mutual insulation conditions for a plurality of semiconductor parts 1013, and at least two stimulating head ends 102 contact different semiconductor parts 1013 respectively to realize the wire function of the traditional nerve stimulation electrode (conduction electrical stimulation) , transmission of collected electrical signals), compared with traditional nerve stimulation electrodes that need to use multiple wires to realize the interactive function between multiple electrodes and pulse generators, only the movable stimulation head 102 is required to cooperate with the fixed set The electrode casing 101 can play an interactive role, avoiding a sharp increase in process cost and maintenance cost caused by too many wires. Each stimulation head end 102 is respectively connected to The pulse generator can make the stimulation head end 102 reach any position during use (the conduction between the stimulation head end 102 is realized through the corresponding semiconductor part 1013), so as to realize the needs of doctors to stimulate and collect various parts of the tissue in the patient's body.

Referring to FIG. 10 , FIG. 10 shows a schematic structural diagram of a nerve stimulation device 1 provided by an embodiment of the present application. The present application also provides a nerve stimulation device 1 . In some possible ways, the nerve stimulation device 1 includes at least one nerve stimulation electrode 10 of the present application. During the operation, the electrical stimulation of the tissue of the organism is realized by implanting the nerve stimulation electrode 10 of the nerve stimulation device 1 into the tissue of the organism and providing electrical stimulation energy to the nerve stimulation electrode 10 . In some possible manners, the nerve stimulation device 1 further includes a driving unit 11 for driving the movement of the stimulation head 102 within the electrode housing 101 (including forward and backward movement and rotational movement). The specific form of the drive unit 11 is not particularly limited, for example, it may be a super micro-motion motor. In some possible manners, the nerve stimulation device 1 further includes an energy supply unit 12 for supplying power to the drive unit 11 .

In a possible implementation, the drive unit 11 may be a micro motor with a very small size, and may be a micro motor with dimensions on the order of millimeters or smaller manufactured using microfabrication technology in modern microelectronics manufacturing technology. It consists of a miniature winding coil, a magnetoresistive sensor, a magnetic rotor and a control circuit. For example, a miniature resonant ultrasonic motor uses the inverse piezoelectric effect of piezoelectric ceramics to excite the resonance of the elastic body, and converts the micro-deformation of the elastic body into the macroscopic motion of the rotor or mover through frictional coupling, so as to realize the satellite resonance type Operation of the ultrasonic motor. Another example is a miniature non-resonant stepping motor, which uses the precise displacement output characteristics of the piezoelectric laminate, combined with the principle of inertial impact or the principle of inchworms, to achieve continuous and precise stepping motion of moving parts.

It should be noted that the shaft component 103 can be driven to rotate by the driving unit 11 , and in a possible implementation manner, the shaft component 103 can be integrated or integrally formed with the base or the output shaft of the driving unit 11 .

In a possible implementation manner, the energy supply unit 12 may include a rechargeable battery, and the energy supply unit 12 may be charged in a wireless charging manner or a wired charging manner, so that the energy supply unit 12 has sufficient electric energy, and the electrical stimulus The energy is released at a specific part of the tissue of the organism through the wire and the stimulating head end 102, so as to realize the electrical stimulation of the specific part of the tissue. Similarly, the power supply unit 12 can also be used to supply power to the driving unit 11 . In a possible implementation manner, the nerve stimulation device 1 may further include a gear box (not shown in the figure) arranged between the drive unit 11 and the shaft member 103, and a first stage may be arranged in the gear box. Or multi-stage gears to provide transmission and speed regulation functions.

Continuing to refer to FIG. 10 , in some possible manners, the nerve stimulation device 1 may further include a control unit 13 . The control unit 13 controls the drive unit 11 to move the stimulation head end 102 . The control unit 13 can also control the stimulation head end 102 to supply electrical stimulation energy. In addition, in some possible ways, the control unit 13 can also analyze the electrical signal collected by the signal collection contact 1022, and then further adjust the position of the stimulation head 102 according to the analysis result, so as to realize precise stimulation. Specifically, when the control unit 13 finds, according to the analysis results, that the electrical signals in some parts are relatively strong, while the electrical signals in other parts are relatively mild, at this time, the control unit 13 can control the driving unit 11 to move the stimulation head end 102 To the part where the electric signal is relatively strong, in order to achieve precise stimulation. Wherein, the relatively strong electrical signal means that the collected electrical signal satisfies one or more of the following conditions: the intensity of the electrical signal is greater than the preset intensity; the waveform of the electrical signal conforms to the preset waveform; the pulse width of the electrical signal is within the preset pulse width range.

Since the nerve stimulation electrode 10 of the present application can realize 360-degree electrical stimulation energy conduction in the circumferential direction, it can precisely locate the part with strong electrical signal, which cannot be achieved by the technical route of setting a limited number of segmented electrodes in the circumferential direction.

For example, as shown in FIG. 11 , FIG. 11 shows a schematic structural diagram of a sliced electrode provided in the related art. Related technologies provide a technical route for stimulating and collecting using sliced electrodes. If 3 sliced electrodes are set in the circumferential direction, the stimulation range corresponding to a single electrode is a fan-shaped area approximately 120 degrees; if 4 electrodes are set, the stimulation range corresponding to a single electrode is 90 degrees; if 6 electrodes are set, a single electrode The corresponding stimulation range is 60 degrees, and the more the number of sliced electrodes arranged in the circumferential direction, the complexity of the process and the cost of manufacturing will rise sharply, and the product yield will decrease accordingly, which is not conducive to the large-scale promotion and application of the product. However, using the nerve stimulation electrode 10 of the present application, it is not necessary to arrange multiple sliced electrodes in the circumferential direction to achieve precise stimulation. During program control, the stimulation head 102 can be controlled to move axially and circumferentially after being implanted in the patient. And stimulate the tissue in real time, collect electrical signals, manually explore the parts with strong electrical signals (or stimulate the pose of the head end 102) or intelligently analyze the parts with strong electrical signals (or stimulate the pose of the head end 102) through software algorithms , so as to help doctors locate the best part suitable for treatment. Among them, pose refers to position information and attitude information.

An embodiment of the present application also provides a nerve stimulation system, the nerve stimulation system including any one of the above nerve stimulation devices.

According to the nerve stimulation system of the present application, it can utilize fewer stimulation contacts to achieve stimulation of biological tissues Electrical stimulation is performed on different parts of the body, and precise stimulation is achieved by collecting and analyzing electrical signals from different parts.

Claims

A nerve stimulation electrode, the nerve stimulation electrode comprising:

an electrode housing which is a hollow tube, and

a stimulating tip, the stimulating tip is arranged inside the electrode housing, and the stimulating tip is used to conduct electrical stimulation energy to the surface of the tissue to electrically stimulate the tissue, and collect electrical signals of the tissue,

Wherein, the stimulating tip can move in the electrode housing along the axial direction of the electrode housing, and/or, the stimulating tip can rotate in the electrode housing along the circumferential direction of the electrode housing.
The nerve stimulation electrode according to claim 1, wherein the nerve stimulation electrode further comprises a shaft member disposed inside the electrode housing and extending along the axial direction of the electrode housing,

Wherein, the stimulating head end is connected with the shaft component and can rotate around the axial direction of the electrode housing, so that the stimulating head end can rotate along the circumferential direction of the electrode housing.
The nerve stimulation electrode according to claim 1, wherein the stimulation tip comprises:

stimulation contacts for conducting electrical stimulation energy to the tissue surface for electrical stimulation of the tissue, and

A signal collection contact, which is used to collect the electrical signal.
The nerve stimulating electrode according to claim 3, wherein the shape of the stimulating contact is one or more of ellipse, circle, rounded rectangle, rectangle, triangle and ring.
The nerve stimulating electrode according to claim 3, wherein the number of the stimulating head ends is greater than one.
The nerve stimulation electrode according to claim 5, wherein the electrode shell comprises a honeycomb insulating part and a plurality of conductive parts separated by the insulating part, any two conductive parts are kept insulated, At least two stimulating tips contact different conductive parts respectively.
The nerve stimulation electrode according to claim 5, wherein the electrode shell comprises a honeycomb insulating part and a plurality of semiconductor parts separated by the insulating part, any two semiconductor parts are kept insulated, each The semiconductor part has a control terminal, a first connection terminal and a second connection terminal, the first connection terminal of each semiconductor part is connected to the signal transmission terminal to conduct the electrical stimulation energy or collect the electrical signal, the second connection terminal of each semiconductor part two connecting ends extend to the tissue;

There are at least two stimulation heads respectively contacting the control terminals of different semiconductor parts for turning on and off The first connection terminal and the second connection terminal of the contacted semiconductor part.
The neurostimulation electrode according to claim 1, wherein the types of diseases that the neurostimulation electrode is used for treatment include epilepsy, tremor, Parkinson's disease, depression, obsessive-compulsive disorder, Alzheimer's disease, autism and drug One or more of Addiction Disorders.
A nerve stimulation device comprising at least one nerve stimulation electrode according to any one of claims 1-8.
The nerve stimulation device according to claim 9, wherein the nerve stimulation device further comprises a driving unit for driving the stimulation tip to move along the axial direction of the electrode casing and along the electrode housing. Circumferential rotation of the casing.
The nerve stimulation device according to claim 9, wherein the nerve stimulation device further comprises a control unit configured to analyze the electrical signal and move the stimulation tip according to the analysis result of the electrical signal, for precise stimulation.
A nerve stimulation system, comprising the nerve stimulation device according to any one of claims 9-11.