WO2023143689A1 - Procédé de production d'une composition en sachet - Google Patents

Procédé de production d'une composition en sachet Download PDF

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Publication number
WO2023143689A1
WO2023143689A1 PCT/DK2023/050019 DK2023050019W WO2023143689A1 WO 2023143689 A1 WO2023143689 A1 WO 2023143689A1 DK 2023050019 W DK2023050019 W DK 2023050019W WO 2023143689 A1 WO2023143689 A1 WO 2023143689A1
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WO
WIPO (PCT)
Prior art keywords
nicotine
water
liquid mixture
pouch
mixture
Prior art date
Application number
PCT/DK2023/050019
Other languages
English (en)
Inventor
Peter BOJE
Original Assignee
Mac Baren Tobacco Company A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mac Baren Tobacco Company A/S filed Critical Mac Baren Tobacco Company A/S
Publication of WO2023143689A1 publication Critical patent/WO2023143689A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof

Definitions

  • This invention relates to a pouch composition, a pouch product comprising said pouch composition in a pouch and a method of manufacturing said pouch composition.
  • Nicotine consumption by smoking has traditionally been the main method of nicotine delivery.
  • smoking as a method of nicotine delivery is being challenged by several alternative systems for nicotine deliv- ery.
  • pouch products containing pouch compositions containing nicotine, also known as snus.
  • These pouch products may vary in type and composition depending on e.g. market of sale and local preferences or regulations.
  • the pouch product is used by placing the pouch in the mouth, preferably between gum and upper lip, where it is left for a desired amount of time delivering nicotine. Nicotine is absorbed by the mucous in the mouth.
  • a method for producing a pouch composition, a pouch product and a pouch composition are provided which in use enable optimized transferal of an active ingredient via the mucous membrane.
  • a pouch product and a pouch composition are pro- vided which in use result in reduced irritation of gums and/or mucous membrane.
  • a pouch product and a pouch composition are provided which in use have an improved feel for the user.
  • a long-lasting flavour with a rapid nicotine delivery' is provided.
  • a quick flavour release in combination with a long- lasting nicotine delivery' is provided.
  • a method to prevent degradation of nicotine is provided.
  • a method for producing a pouch composi- tion comprising one or more sugar alcohols in a total amount of 0 - 22 wt%, one or more intense sweeteners in a total amount of 0 - 5 wt%, water in an amount of 8 - 51 wt%, at least one texturizing agent in a total amount of 0,3 - 5 wt%, at least one water insoluble fibre, nicotine, wherein the method comprises the steps of i.
  • nicotine, water and flavour are mixed in a liquid mixture which is followingly mixed with the dry mix an even distribution of flavour, water and nicotine in the dry mix is achieved, thereby avoiding that flavour and nicotine are not distributed in a sim- ilar manner throughout the obtained pouch composition. This is especially important as flavours at least partly may be added to mask the taste of nicotine.
  • an advantage of the pouch product provided by the present method is that the flavor may be evenly distributed throughout the entire fiber so the user will have a pre- sent taste of flavor during the whole period of usage of a pouch containing the pouch product.
  • an active ingredient such as nicotine alone or in combination with any other active ingredients mentioned herein.
  • This active ingredient may have a release through a longer period which is an advantage for active ingredients that has a bad taste or that needs to be delivered more slowly due to the effect of the active ingredient.
  • An advantage of adding nicotine, water and flavour in a combined liquid mixture is that the taste of the active ingredient(s) may permanently be masked by the flavor because there is simultaneous release of the flavor and the active ingredient that is evenly dis- tributed throughout the particle.
  • nicotine, water and flavour are provided as more than one liquid mixture, it may be possible to control where the majority of nicotine is in the fibres relative to the majority of flavors. This can be controlled by adding liquid mixtures one after another. For ex- ample, first adding a liquid nicotine mixture and then a liquid flavor mixture may result in a product which provides a quick release of flavors in use which will cover nicotine taste in the beginning of using the snus. Alternatively, adding flavors first and then nic- otine may result in a product which provides a quicker delivery of nicotine in the be- ginning of use and then more long-lasting flavours.
  • the relative position of nicotine and flavor in the none water-soluble particles may be controlled so that the centre of each fibre has a large concentration of flavours and the nicotine will be mainly at the surface. This may provide a long-lasting flavour with a rapid nicotine delivery.
  • the relative position of nicotine and flavor in the none-water soluble par- ticles may be controlled so the centre of the fibres has a large concentration of nicotine, and the flavour will be mainly in the surface of the fibres. This may provide a quick flavour release in combination with a long-lasting nicotine delivery.
  • Advantages of adding nicotine in one liquid mixture and flavor in a second liquid mix- ture may as described above be that it is possible to control how nicotine and flavor is absorbed in the fibers and thereby control the release of nicotine and flavors of the product in use.
  • the method may further comprise steps of injecting at least one of the liquid mixtures in the mixer by compressed nitrogene and/or having purge flows by seals in the mixer with compressed nitrogene in order to prevent degradation of nicotine by oxygen both during mixing and when the fibres are stored later in nitrogen atmosphere.
  • the method may in addition or alternatively comprise steps of removing oxygen bysuction or vacuum in one or more parts of the process.
  • This may have the advantage that, when liquids containing oxygen, eg. Propane- 1,2, 3 -triol, Propane-1, 2-diol and/or Butan- 1,3 -diol, Water is mixed with nicotine and the dissolved oxygen starts a degra- dation process, the freed excess oxygen may be removed by the suction and/or vacuum thereby making the product more stable.
  • liquids containing oxygen eg. Propane- 1,2, 3 -triol, Propane-1, 2-diol and/or Butan- 1,3 -diol
  • the suction or vacuum may advantageously be applied at step ii.
  • Propane- 1,2, 3 -triol is added to the second liquid mixture com- prising water and nicotine before mixing with the dry mix.
  • the liquid mixture comprising water and flavour and optionally nicotine and/or the second liquid mixture comprising water and nicotine is injected into the dry mix by compressed nitrogen preferably in conjunction with nitrogen purge in seals in- side a mixer preventing oxygen atmosphere in the mixing step in order to prevent nico- tine degradation by oxygen.
  • the liquid mixture comprising water and flavour and optionally nicotine and/or the sec- ond liquid mixture comprising water, nicotine and optionally Propane-1, 2, 3-triol may be kept under vacuum of 0,5 bar or less for 30 seconds or more before adding to drymix.
  • the liquid mixture comprising water and flavour and optionally nicotine and/or the sec- ond liquid mixture comprising water, nicotine and optionally Propane- 1,2, 3 -tri oldiol may be kept under vacuum of 0,5 bar or less for 30 seconds or more under stirring.
  • the liquid mixture comprising water, nicotine and/or flavour and/or the second liquid mixture comprising water and nicotine may comprise one or more solvents for dissolv- ing nicotine and wherein liquid mixture comprising water, nicotine and/or flavour and optionally a nicotine solvent and/or the second liquid mixture and optionally a nicotine solvent is under vacuum of 0,5 bar or less for 30 seconds or more before adding to drymix and/or while being mixed with the dry mix.
  • glycerin is defined as Propane-1, 2, 3-triol
  • PG is defined as Propane- 1,2-diol
  • Snus, snuff is defined as none water soluble botanical fibers in a none water soluble saliva permeable bag with ingredients such as nicotine, flavors, pH regulating agents, anticaking agents, preservatives, texturizing agents and sugar alcohols
  • not all water is provided in step ii in which case additional water is added in an optional subsequent step in order to provide a pouch composition with full water content.
  • the insoluble fibre is one or more botanical fibers for example fibers from wheat, oat, buckwheat, potatoes, bamboo, cellulose, apple, cacao, beets, sugar beets, wood, seaweed, barley, rye, com, tomato and any combination hereof.
  • the one or more fibers may be chosen to provide the right water content ranging from very' dry products to very' moist products.
  • the fibers in their capacity of being a water insoluble in- gredient may continue to provide volume to the pouch product during use as they are not dissolved and released by saliva.
  • the majority of the other ingredients present maybe water soluble, whereby they may be dissolved by saliva and released from the pouch composition through the pouch and provide taste, aroma and/or effect of the active in- gredient to the user.
  • At least one of the one or more water insoluble fibers may fibers that can contain from 150 to 1000 wt% of water and are approved for usage in food and/or pharma, such as or up to 200%, 250%, 300%, 350%, 400%, 450%, 500%, 550%, 600%, 650%, 700%, 750%, 800%, 850%, 900%, 950%, 1000%, 200 - 800%, 200 - 600% wt% of water.
  • Water may for example be present in a contraction of 8 - 55 wt%, such as 10, 20, 25, 30, 35, 40, 45, 48, 50 wt% water.
  • the fibers are selected to have a length of 10 - 300pm, such as 20 - 200 pm, such as 25 - 100 pm, such as 30 - 75 pm.
  • a high content of fibers may provide a product with a dry feel to the user.
  • a dry product may for some users have an undesirable feel and may also result in a reduced impact of the active ingredient as the saliva used to transfer ingredients through the mucous mem- brane may be absorbed by the fibers.
  • texturizing agents may be provided in an amount to balance the dryness of the fibers and provide a desired feeling of moisture and softness to the product.
  • the pouch composition may comprise one or more texturizing agents, for example one or more of agar, guar gum, alginate salts and/or arabica gum which may act as a gelling agent when absorbing water or other liquids.
  • the texturizing agent is each present in an amount of 0.1 — 5 wt%, e.g. in an amount of or up to 0,5, 1, 1,5, 2, 2,5, 3, 3,5, 4, 4.5 or 5 wt%.
  • the total content of texturizing agent may e.g. be 0.1 - 5 wt%.
  • the active ingredient may be chosen to provide a desired effect to the pouch product and pouch composition.
  • nicotine may be present to provide a nicotine de- livery' product, whereby an alternative to products providing nicotine by smoking is achieved.
  • Nicotine may be added to the liquid phase and/or in step b) and/or g) as dissolved in a nicotine solvent such as Propane-1, 2, 3-triol, Propane- 1 ,2-dioi and/or Butan- 1 ,3 -diol as these nicotine solvents may provide sweetness as well as may help balance moisture.
  • a nicotine solvent such as Propane-1, 2, 3-triol, Propane- 1 ,2-dioi and/or Butan- 1 ,3 -diol as these nicotine solvents may provide sweetness as well as may help balance moisture.
  • Propane-1, 2, 3-triol, Propane- 1,2-diol and/or Butan- 1,3 -diol are all known solvents for use in dilution of flavors and other strong ingredients. They are in general tasteless and have a little sweetness from the OH groups. They are fully mixable with water in the range 0 to 100 % but also mixable with other things like nicotine and manyflavors.
  • a pouch composition is achieved which has a texture with a desired sensation of moisture and firmness for the user.
  • the at least one active ingredient may be present in a concentration of 0.01 - 20% de- pending on type and intended effect.
  • One or more active ingredients may be present.
  • other active ingredients may be added in combination with nicotine.
  • Active ingredients may be nicotine, caffeine, cannabinoid such as CBD, CBT and other oils extracted from hemp or cannabis, melatonin, vitamin A, vitamin B, vitamin C, vit- amin D, vitamin E, antioxidants, minerals, salt, pre-biotics, pro-biotics, pain killers or antihistamines, Viagra, products for teeth and gum health such as anti-caries agents, acid buffering agents, tooth whiteners, desensitizers, saliva enhancers, herbals such as chamomile, tea such as green tea, thyme, oregano, ginger, turmeric, mint, appetite sup- pressors, cough suppressors, eucalyptus, relaxing agents, energizing agents, caffeine, ginseng, taurine and/or breath fresheners.
  • cannabinoid such as CBD, CBT and other oils extracted from hemp or cannabis
  • melatonin vitamin A, vitamin B, vitamin C, vit- amin D, vitamin E, antioxidants, minerals, salt, pre-biotic
  • Nicotine may advantageously be provided in a concentration of 0.1 — 5 wt% equivalent to free bae nicotine, depending on the desired strength of the resulting nicotine pouch composition and pouch product in order to achieve a desired nicotine delivery to the user.
  • the amount of nicotine in the pouch composition is up to or between any of 0.2, 0.5 1, 1.5, 1.6, 2, 2,5, 3, 3,5, 4, 4,5 5 wt%, such as 0.2 - 4 wt%, 0.3 - 3.5% wt%, 0, 4 - 3 wt%.
  • the nicotine may be provided in the form of free base nicotine, synthetic nicotine, nic- otine salt and/or as nicotine bound to a resin.
  • Free base nicotine refers to (S)-3-(l-Methyl-2-pyrroli-dinyl)pyridine, (- -)- 1 -Methyl -2- (3-pyridyl)pyrrolidine CAS number 54-11-5.
  • the wording synthetic nicotine may refer to (S)-3-(l-Methyl-2-pyrroli-dinyl)pyridine derived from a chemical synthesis or a mixture of (S)-3-(l-Methyl-2-pyrroli-dinyl)pyr- idine and (R)-3-(l-Methyl-2-pyrroli-dinyl)pyridine derived from a chemical synthesis. Also referred to as R,S-nicotine. CAS Number 6912-85-2.
  • nicotine bound to a resin may refer to a plastic resin such as, but not limited to, Amberlite IRP64, Purolite Cl 15HMR or Doshion P551 mixed with free base nico- tine.
  • free nicotine salt may refer to any salt that is obtained from free base nicotine.
  • Such salts could be (but not limited to): nicotine hydrochloride, nicotine dihy- drochloride, nicotine monotartrate, nicotine bitartrate, nicotine bitartrate dihydrate, nic- otine sulphate, nicotine zinc chloride monohydrate and nicotine salicylate, and mixtures thereof.
  • nicotine is provided in more than one form.
  • a combination of nicotine may be advantageous in case of polarcrilex (NICOTINE. POLACRILEX 20% NP CAS No. 96055-45-7) and free base nicotine, such combinations may for example be 30 % polarcrilex and 70 % free base nicotine.
  • the polarcrilex gives a long slow release of nicotine where the free base gives a quick release for immediate nicotine craving.
  • a combination of nicotine salt and freebase nitocine can also be used to give another experience of how the nicotine is delivered through the oral mucosa.
  • a second active ingredient taken from the group comprising nic- otine, cannabinoids such as CBD, melatonin, turmeric, chamomile, and similar active ingredients that relax your body is also present.
  • cannabinoids such as CBD, melatonin, turmeric, chamomile, and similar active ingredients that relax your body
  • nicotine may advantageously be provided together with active ingredients for teeth and gum health, vitamin supplements, calming effects, oral hygiene, appetite regulating and similar.
  • nicotine may advantageously be provided together with active ingredients for providing an increased feeling of energy such as caffeine and/or canna- binoid such as CBD, CBT and other oils extracted from hemp or cannabis, melatonin, vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, antioxidants, minerals, salt, pre- biotics, pro-biotics, pain killers or antihistamines, Viagra, products for teeth and gum health such as anti-caries agents, acid buffering agents, tooth whiteners, desensitizers, saliva enhancers, herbals such as chamomile, tea such as green tea, thyme, oregano, ginger, turmeric, mint, appetite suppressors, cough suppressors, eucalyptus, relaxing agents, energizing agents, caffeine, ginseng, taurine and/or breath fresheners.
  • active ingredients for providing an increased feeling of energy such as caffeine and/or canna- binoid such as CBD, CBT and other oils extracted from hemp or cannabis, melatonin, vitamin A
  • the concentration of the at last one first active ingredient is 0,01 --- 5 wt% such as or up to 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5 wt% and/or wherein concentration of the second active ingredient is 0,1 - 5 wt% such as or up to 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5 wt% and/or wherein the ratio between the first active ingredient and the second active ingredient is 0,1 - 1.
  • the one or more sugar alcohol may be one or more of sorbitol, mannitol, xylitol, hy- drogenated starch hydrolyzates, maltitol, isomalt, erythritol, lactitol, poly dextrose alone or in combination.
  • These sugarless sweeteners may be provided to at sweetness to the pouch composition but may also be included as a humectant.
  • a first of the one or more sugar alcohols may be present in an amount of 0 - 12 wt%, such as or up to 0.1, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 lor 12 wt°v and optionally a second and/or third sugar alcohol may be present in an amount of 0 -12 wt% such as or up to 0.1, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, l lor 12 wt%.
  • the pouch composition may comprise intense sweeteners in a concentration of 0.01 - 5 wt%, such as or up to 0.05, 0.1, 0.5, 1, 1.5, 2 or 2.5 wt% combination with or as an alternative to the one or more sugar alcohol.
  • the intense sweeteners may e.g. be Acesulphame potassium, (950) Advantame (969), Alitame (956), Aspartame (951), Aspartame-acesulphame salt (962), Cyclamate (952), Monk fruit extract Neotame (961), Saccharin (954), Steviol glycosides (960), Sucralose (955) and/or Thaumatin (957).
  • a combination of two or more sugar alcohols may be used in the pouch composition.
  • xylitol and sorbitol may be used together in order to achieve a combination of a nice cooling effect from xvlitol and a good humectant effect from sorbitol as well as a specific amount of sweetness may be provided to the pouch com- position.
  • the ratio between a first sugar alcohol and a second sugar alcohol may for example be 1 : 1 - 1 : 100, such as 1 :50, such as 1 :25, such as 1 : 10, such as 1 :5 whereby an optimum of e.g. sweetness, cooling or humectance from one is combined with added density from another.
  • the sugar alcohols may be added to e g. act as humectants, to help control density, to help deliver nicotine to the oral mucosa and to have an improved oral hygiene.
  • a texturizing agent may be added to give a nice smooth water full feeling. Together with humectants in the form of sugar alcohols, glycerine and similar, they keep the water content high and a nice moist piece of snuff is always available, also in hot and dry areas.
  • salt in form of sodiumchloride, ammoniumchloride, and/or po- tassium chloride is added in an amount of 0,05 - 18 wt%, such as or up to 0.1, 0.5, 1,
  • tobacco is present in an amount of 0 - 5 wt%, such as up to 4%, 3%, 2%, 1%, 0,5%.
  • a product with a combination of an active ingredient, such as nic- otine, with tobacco may provide a product with a reduced amount of tobacco still having a desired nicotine content. This combination may be advantageous in that the user still gets the tobacco taste, but a much lower amount of the none-healthy ingredients in to- bacco beside nicotine.
  • Tobacco may also in some embodiments be added in combination with other active ingredients mentioned herein.
  • Tobacco may be in the form tobacco rustica or tobacco nicotiana and/or a mixture of them. Depending on mixture it can be very’ strong with a nicotine content up to 17 % from tobacco rustica or a milder version mixed with none-tobacco products and/or to- bacco nicotiana products.
  • Tobacco may for example be provided as whole or in partic- ulate form with a size between 0.1 - 6 mm, such as or up to 0.2, 0.5, 1, 1.5, 2, 2.5, 3,
  • the pouch composition comprises one or more preservatives, one or more pH regulating agents, and/or one or more flavours.
  • a flavor may in some embodiments provide aroma and/or taste.
  • the flavour may be any of but not limited to: coconut, coffee, chocolate, vanilla, grape fruit, orange, lime, menthol, hemp, , liquorice, caramel aroma, honey aroma, peanut, walnut, cashew, ha- zelnut, almonds, pineapple, strawberry, raspberry, tropical fruits, cherries, cinnamon, peppermint, wintergreen, spearmint, eucalyptus, and mint, fruit essence such as from apple, pear, peach, strawberry', apricot, raspberry, cherry, pineapple, lemongrass, lime, jalapenos, chili (capsaicin), citrus, tobacco fl avorvari mixer and/or plum essence.
  • oils including peppermint, spearmint, men- thol, eucalyptus, clove oil, bay oil, anise, thyme, cedar leaf oil, nutmeg, and oils of the fruits mentioned above.
  • the one or more flavours may each be present in an amount of 0 - 15 wt% such as 2 - 12 wt% such as or up to 1, 2, 3, 4, 5, 6, 7 ,8, 9, 10, 11, 12, 13, 14, 15 wt%. Adding up to a total amount of 0 - 15 wt%
  • Preservatives may be selected as one or more of sorbic acid, sodium sorbate, potassium sorbate, calcium sorbate, benzoic acid, sodium benzoate, calcium benzoate, propionic acid, sodium propionate, potassium propionate, calcium propionate.
  • pH regulating agents may be selected as one or more of sodium bicarbonate, sodium carbonate, magnesium carbonate, magnesium bicarbonate, potassium carbonate, potas- sium bicarbonate, ferrous carbonate.
  • nicotine type and other ingredi- ents with acidic / caustic properties E.g.
  • sodiumcarbonate to elevate pH to more than 8 if polarcrilex or nicotinesalts are used.
  • the preservative is present in an amount of 0,01 - 2 wt%, such as or up to 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8,1.9 2 wt%
  • the pH regulating agent is present in an amount of 0,2 - 4 wt%
  • the flavour is present in an amount of 2 --- 12 wt%.
  • Water may be any of e.g. tap water, ionexchanged water, reversed osmosis and/or dis- tilled water.
  • the pouch composition may further comprise one or more solvents, such as flavour solvents, such as
  • flavour solvents may comprise ethanol in combination with water in a 0,5 to 80 wt%.
  • the pouch composition may also comprise one or more flavor solvents such as Propane- 1,2, 3-triol, Propane- 1,2-diol and/or Butan-l,3-diol.
  • flavor solvents such as Propane- 1,2, 3-triol, Propane- 1,2-diol and/or Butan-l,3-diol.
  • the nicotine solvents may also provide sweetness as well as may help balance moisture by acting as humectants.
  • the flavor solvents can be used to adjust the transporta- tion time of nicotine to the oral mucosa. This adjustment can be done by using the fact the free base nicotine has higher affinity towards none-polar solvents than polar sol- vents. If a part, such as the center or surface region, of the pouch contains more solvent that is less polar than water, this part will automatically have a higher percentage of nicotine, especially when the pouch is worked in the mouth.
  • the present application also relates to a pouch product comprising a pouch and a pouch composition as described herein.
  • the pouch may in some embodiments be at least partly from a water permeable mem- brane e.g. a non-woven fabric or paper.
  • the pouch comprises at least one chamber for containing the pouch composition.
  • the at least one chamber When filled, the at least one chamber may have a length of 2 - 50 mm, such as 10 - 40mm, such as or up to 20, 25, 30, 35, 40 mm.
  • the at least one chamber When filled, the at least one chamber may have a width of 5 - 20 mm, such as or up to 7 - 15mm, such as or up to 5, 7, 10, 12, 15, 17, 20mm.
  • the at least one chamber When filled, the at least one chamber may have a thickness of 2 - 12 mm, such as or up to 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 mm.
  • the pouch product may be manufactured as follows.
  • the pouch composition may be provided by a process in which all dry matter is weighted off and added together to a dry mix. Similarly, all liquid matter may be added together and preferably mixed to obtain a liquid mix, or the liquid matter may be added together in two or more liquid mixtures.
  • the liquid mix(s) may hereafter be added to the dry mix by spraying during mixing. After all liquid has been added to the dry mix, stirring may be continued until a pouch composition with an even distribution of ingredients is obtained.
  • the pouch composition may be added to storage bags, preferably under inert conditions for storage until further process steps. Alternatively, the pouch composition may directly be used in following process step.
  • the pouch composition may then be filled into pouches with at least one chamber for the pouch composition where after the pouch is closed. If de- sired, further water may be sprayed unto the pouch with pouch material.
  • the method may comprise steps where e.g. oxygen is removed, for example when the liquid matter is added together and/or when one or more of the liquid mix(s) are added to and/or mixed with the dry mix.
  • Each pouch with pouch composition may e.g. weigh 0,425 g before a final water addi- tion step and 0,525 g after water addition.
  • the water content in the pouch composition in the pouch product may thus be higher than in the pouch composition before being filled into the pouch in case the pouch com- position comprises an intermediate water content and the final water content is achieved in a final hydration step (water addition step).
  • This pouch composition with an interme- diate water content may be named an intermediate pouch composition.
  • the present also relates to a pouch composition provided by the method described herein.
  • Said pouch composition comprising at least one water insoluble fibre, at least one ac- tive ingredient, at least one texturizing agent, at least one sugar alcohol in a total amount of 0- 20 wt%, one or more intense sweeteners in a total amount of 0 - 8wt%, water in a total amount of 8 - 50 wt%,
  • the pouch composition may also comprise any of the other ingredients described herein such as preservatives, flavours and/or pH adjusting agents in amounts described above.
  • compositions F1 - F7 are shown. The compositions are intended to illustrate different embodiments of the present invention and are not to be construed as limiting to the invention.
  • Compositions F1 - F7 are either the finished pouch composition in- tended to be filled in to pouches without a water addition step or pouch compositions in a pouch to which a final amount of water has been added, i..e. pouch composition with full water content.
  • F1 Composition F1 is based on wheat fibers and free base nicotine, texturizing agent is Arabica Gum. It is a sweet product for maximum delivery of flavor and nicotine.
  • Composition F2 is based on MCC (micro crystalline cellulose) fibers and nicotine based on freebase nicotine mixed with an ion exchange resin.
  • Texturizing agent is Arabica Gum. It is a sweet product for maximum delivery of flavor and a slow release of nicotine. The slow release of nicotine provides a better lifetime for the product be- cause the nicotine does not evaporate, and it gives an overall better nicotine uptake because the nicotine is slowly going to the oral mucosa. This also helps less nicotine to enter the stomach with can create stomach problems for users.
  • Composition F3 is based on sea wheat fibers and free base nicotine in VG.
  • the 20 nicotine in VG makes nicotine safer to handle and it does not so easy get oxidated by- air because it is diluted.
  • Texturizing gent is Guar Gum.
  • Guar Gum is a bit more jelly like than Arabica Gum and creates a smooth feeling outside the pouch when used orally. It is a sweet product for maximum delivery’ of flavor and nicotine.
  • Composition F4 is based on bamboo fibers and free nicotine salt.
  • Texturizing agent is Sodium Alginate in combination with a free nicotine salt. Free nicotine salts are more acidic than free base nicotine, therefor sodium carbonate is added ad pH adjusting agent. Free nicotine salts generally enter the body more through the throat than the upper oral mucosa. This is a different feeling that some users prefer when using snuff
  • Composition F5 is based on wheat fibers and free base nicotine.
  • Texturizing agent is Agar that is known not be especially white. It is a salty product that together with ammoniumchloride provides maximum nicotine delivery'.
  • Composition F6 is based on w’heat fibers and free base nicotine.
  • Texturizing agent is Guar Gum that is known to provide a moist feeling outside on the snuff. It is a salty product that together with ammoniumchloride provides maximum nicotine delivery .
  • Composition F7 is based on wheat fibers and free base nicotine. Tobacco is added to give a tobacco flavor and because some countries insist on tobacco in the snuff. Tex- turizing agent is Guar Gum that is known to provide a moist feeling outside on the snuff. It is a salty product that together with ammoniumchloride provides maximum nicotine delivery'. Table I
  • compositions in II and III are pouch compositions with a low water content (may be named intermediate pouch compositions) i.e. pouch composition intended to be submitted to a hydration step pref- erably after the pouch composition has been added to a pouch.
  • Table II A salty formulation with 16mg nicotine pr 100g: Table III A sweet formulation with 20mg nicotine pr 100g:

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Abstract

L'invention concerne un procédé de production d'une composition en sachet, ladite composition en sachet comprenant au moins une fibre insoluble dans l'eau, de la nicotine, au moins un alcool de sucre à raison de 0 à 22 % en poids, un ou plusieurs édulcorants intenses à raison de 0 à 8 % en poids, de l'eau à raison de 8 à 48 % en poids. Le procédé comprend les étapes consistant à i. fournir un mélange sec comprenant une ou plusieurs desdites fibres insolubles dans l'eau, un ou plusieurs desdits alcools de sucre, un ou plusieurs agents de texturation, éventuellement un agent anti-agglomérant, éventuellement un agent d'ajustement de pH, éventuellement un conservateur, éventuellement un sel ; ii. fournir un mélange liquide contenant de l'eau, de la nicotine et un arôme ; iii. mélanger le mélange liquide et le mélange sec pour obtenir une composition en sachet.
PCT/DK2023/050019 2022-01-28 2023-01-27 Procédé de production d'une composition en sachet WO2023143689A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA202270040A DK181550B1 (en) 2022-01-28 2022-01-28 Method for producing a pouch composition
DKPA202270040 2022-01-28

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019110076A1 (fr) * 2017-12-08 2019-06-13 Fertin Pharma A/S Absorption élevée de nicotine
US20210169889A1 (en) * 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral products
EP3868224A1 (fr) * 2020-02-18 2021-08-25 Nerudia Limited Article sans fumée
US20210307375A1 (en) * 2019-06-07 2021-10-07 Ncp Nextgen A/S Nicotine pouch composition
EP3937662A1 (fr) * 2019-06-07 2022-01-19 NCP NextGen A/S Composition en sachet de nicotine sans tabac destinée à être administrée par voie orale

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019110076A1 (fr) * 2017-12-08 2019-06-13 Fertin Pharma A/S Absorption élevée de nicotine
US20210307375A1 (en) * 2019-06-07 2021-10-07 Ncp Nextgen A/S Nicotine pouch composition
EP3937662A1 (fr) * 2019-06-07 2022-01-19 NCP NextGen A/S Composition en sachet de nicotine sans tabac destinée à être administrée par voie orale
US20210169889A1 (en) * 2019-12-09 2021-06-10 Nicoventures Trading Limited Oral products
EP3868224A1 (fr) * 2020-02-18 2021-08-25 Nerudia Limited Article sans fumée

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAS , no. 96055-45-7
CAS, no. r 54-11-5

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