WO2023134147A1 - Temperature control unit for mini near-infrared detector and temperature control method - Google Patents
Temperature control unit for mini near-infrared detector and temperature control method Download PDFInfo
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- WO2023134147A1 WO2023134147A1 PCT/CN2022/108217 CN2022108217W WO2023134147A1 WO 2023134147 A1 WO2023134147 A1 WO 2023134147A1 CN 2022108217 W CN2022108217 W CN 2022108217W WO 2023134147 A1 WO2023134147 A1 WO 2023134147A1
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- infrared probe
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- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000001816 cooling Methods 0.000 claims abstract description 43
- 239000000523 sample Substances 0.000 claims description 56
- 239000011521 glass Substances 0.000 claims description 11
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- 238000012937 correction Methods 0.000 claims description 5
- 102220013598 rs4252582 Human genes 0.000 claims description 3
- 102220038624 rs7748563 Human genes 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 8
- 239000000463 material Substances 0.000 description 7
- 238000001228 spectrum Methods 0.000 description 6
- 238000004497 NIR spectroscopy Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002329 infrared spectrum Methods 0.000 description 4
- 230000017525 heat dissipation Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012569 chemometric method Methods 0.000 description 2
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- 238000010892 electric spark Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
Definitions
- the invention relates to the technical field of spectrometers, in particular to a miniature near-infrared probe temperature control device and a temperature control method.
- the near-infrared spectrum is produced by the absorption of light by molecular vibrations, which is mainly generated by the transition from the ground state of molecular vibrations to high-energy states.
- Near-infrared spectroscopy not only carries the characteristic information of the molecule itself such as structure and functional group, but also contains information on intramolecular and intermolecular forces such as hydrogen bonds. However, these forces themselves are easily affected by external conditions such as temperature. Changes in temperature cause changes in intra- and intermolecular forces, which in turn affect the vibrational modes of the molecules. Therefore, near-infrared spectroscopy is more sensitive to temperature changes, which limits the application of near-infrared spectroscopy.
- the near-infrared spectrum analyzer is an instrument that uses the absorption characteristics of the sample to near-infrared light of different wavelengths to analyze the sample. Studies have shown that changes in temperature will produce a shift in the vibration spectrum, making the measurement results of near-infrared spectroscopy at a specific temperature only applicable to the quality analysis of samples at this temperature. Once the temperature around the near-infrared probe of the near-infrared spectroscopy analyzer deviates The temperature will affect the quality measurement results of the sample.
- temperature correction methods are often used, such as chemometric methods, global implicit or explicit temperature compensation, and removal of temperature-sensitive wavelengths.
- Chemometric methods are suitable for samples with large water content, which has limitations; global implicit or temperature compensation methods need to measure spectra and sample measured values at different temperatures during modeling, which increases the workload; remove the temperature-sensitive A wavelength that reduces the accuracy of the model. Therefore, although the above-mentioned existing methods can correct the influence of temperature under certain conditions, they all have certain defects.
- the sample-material temperature can reach a maximum of 70-75°C, far exceeding the operating temperature of the probe (-20-40°C, non-condensing). , the existing above-mentioned temperature correction method is no longer applicable.
- temperature has a great influence on the measurement of the miniature near-infrared probe of the near-infrared spectrum analyzer, but the existing technology cannot fundamentally eliminate the influence of temperature on the spectrum through external control methods. It is easy to cause poor detection accuracy due to high ambient temperature. Therefore, the existing technology cannot effectively guarantee the stable operation of the miniature near-infrared probe in a specific temperature range, and cannot meet the detection requirements.
- the technical problem to be solved by the present invention is to overcome the defect in the prior art that the miniature near-infrared probe cannot always work stably within a specific temperature range.
- the present invention provides a miniature near-infrared probe temperature control device, including a cooling jacket, an air inlet is arranged on the cooling jacket, a vortex tube is connected to the air inlet, and the vortex tube It is connected with an air compressor, and an exhaust hole is also arranged on the cooling jacket.
- the vortex tube and the air inlet are connected by threads.
- the middle part of the vortex tube is provided with an air inlet, and the two ends of the vortex tube are respectively a cold air outlet and a hot air outlet, and the cold air outlet and the cooling jacket The air inlets are connected.
- the cooling jacket is provided with a plurality of exhaust holes, and the plurality of exhaust holes are arranged in a rectangular array or an annular array.
- the outer wall of the cooling jacket protrudes outward to form a bump, and the exhaust hole is arranged on the bump.
- the exhaust holes are oblique holes.
- the exhaust holes are circular or oval.
- the internal temperature is used to adjust the output pressure of the air compressor output to the vortex tube so that the temperature around the infrared probe can be reduced.
- the output pressure Pt of the air compressor output to the vortex tube is calculated by the following formula:
- Tst is the set temperature of the miniature near-infrared probe
- Trt is the internal temperature of the tank of the one-step granulator
- the tank body of the one-step granulator is provided with a mounting hole, the mounting hole is connected with a mounting plate, and the mounting plate is provided with a first window hole and a second window hole, so
- the first window hole is connected to transparent glass
- the second window hole is connected to sapphire glass
- the miniature near-infrared probe is connected to the outside of the second window
- the near-infrared light emitted by the miniature near-infrared probe passes through the sapphire glass. Shot into the inside of the tank of the one-step granulator.
- the miniature near-infrared probe temperature control device and temperature control method described in the present invention can directly control the external environment temperature of the miniature near-infrared probe, so that the miniature near-infrared probe can work in a stable specific temperature range, and will not be affected by excessive ambient temperature. and affect the detection accuracy.
- Fig. 1 is the structural representation of miniature near-infrared probe temperature control device of the present invention
- Fig. 2 is a schematic structural view of the cooling jacket in Fig. 1;
- Fig. 3 is a sectional view of the cooling jacket in Fig. 2;
- Fig. 4 is the structural representation of mounting plate
- Fig. 5 is the near-infrared probe temperature change diagram under the implementation of temperature control and non-implementation of temperature control;
- Fig. 6 is the material spectrogram under implementing temperature control and not implementing temperature control
- the present invention discloses a kind of miniature near-infrared probe temperature control device, comprises cooling jacket 1, is provided with air inlet 11 on cooling jacket 1, is connected with vortex tube 2 at air inlet 11, The vortex tube 2 is connected with the air compressor, and the cooling jacket 1 is also provided with an exhaust hole 12, which is convenient for the airflow to take away heat and reduce the temperature of the probe.
- the miniature near-infrared probe When in use, the miniature near-infrared probe is installed inside the cooling jacket 1, and cold air is input into the inside of the cooling jacket 1 through the vortex tube 2, thereby reducing the ambient temperature around the miniature near-infrared probe, so that the miniature near-infrared probe can always be in a specific temperature range It works stably and maintains its detection accuracy.
- the vortex tube 2 is used for cooling and heat dissipation, without moving parts, and the cold air generated can be as low as tens of degrees below zero.
- the cooling range is wide, and cold air can be generated quickly, and the cooling speed is fast; No chemical substances are used, no electric sparks are generated, the whole process is safer, and the operation safety can be effectively guaranteed.
- the above structure achieves cooling through air cooling. Compared with water cooling, which needs to arrange complex pipelines, the air cooling structure is simpler and easier to arrange.
- exhaust holes 12 and air inlets 11 are respectively located on both sides of the cooling jacket 1 and are oppositely arranged.
- cooling jacket 1 can be made of a material with better thermal conductivity to further enhance the heat dissipation effect.
- the vortex tube 2 and the air inlet 11 are connected by threads, the connection is reliable, and the installation and maintenance are convenient.
- a sealing ring can be arranged between the vortex tube 2 and the air inlet 11 .
- the middle part of the vortex tube 2 is provided with an air inlet 21, the compressed air output by the air compressor enters the vortex tube 2 from the air inlet 21, and the two ends of the vortex tube 2 are cold air outlet 22 and hot air outlet respectively 23.
- the cold air outlet 22 communicates with the air inlet 11 of the cooling jacket 1, so that the cold air output by the cold air outlet 22 of the vortex tube 2 enters the inside of the cooling jacket 1 through the air inlet 11, thereby realizing the cooling of the inside of the cooling jacket 1. environment to cool down.
- the cooling jacket 1 is provided with a plurality of exhaust holes 12 arranged in a rectangular array or an annular array to enhance air flow and accelerate heat dissipation.
- the outer wall of the cooling jacket 1 protrudes outward to form a bump 13 , and the exhaust hole 12 is disposed on the bump 13 .
- the strength of the cooling jacket 1 can be enhanced through the arrangement of the protrusions 13, and the deformation of the area where the exhaust hole 12 is located can be prevented from being deformed due to long-term use.
- the exhaust holes 12 are oblique holes to better ensure the air flow effect.
- the exhaust hole 12 is circular or elliptical, but not limited to the above-mentioned shapes, and may also be other shapes.
- the air pressure of the air compressor ranges from 0.1 MPa to 0.7 MPa, which is adjusted according to different equipment or operating conditions of different processes.
- the one-step granulator is a commonly used equipment in the medical field. It is used to condense the drug powder into loose small particles and dry them, and finally form ideal uniform microporous spherical particles. It can be completed in one step in the tank of the one-step granulator. Three processes of mixing, granulating and drying.
- this embodiment also discloses a method for controlling the temperature of the miniature near-infrared probe by using the above-mentioned temperature control device.
- the miniature near-infrared probe is installed on the outer wall of the tank of the one-step granulator, and Adjust the output pressure of the air compressor to the vortex tube 2 according to the internal temperature of the tank of the one-step granulator so that the temperature around the infrared probe can be reduced.
- Tst is the set temperature of the miniature near-infrared probe
- Trt is the internal temperature of the tank of the one-step granulator
- the above formula adjusts the air pressure output by the air compressor through the temperature of the inner cavity of the granulator tank, which can more accurately control the cooling effect and ensure that the near-infrared probe equipment can work normally within a specific temperature range.
- the temperature of the inner cavity of the granulator tank can be transmitted to the central control host.
- the hollow host can adjust the pressure of the compressed air according to the temperature inside the granulator tank, thereby Carry out overall cooling of the near-infrared probe equipment.
- the tank body of the one-step granulator is provided with a mounting hole, and a mounting plate 3 is connected to the mounting hole.
- Two window holes 32 the first window hole 31 is connected with transparent glass 33, such as toughened glass, the second window hole 32 is connected with sapphire glass 34, the miniature near-infrared probe is connected outside the second window, and the miniature near-infrared probe emits
- the near-infrared light is injected into the tank body of the one-step granulator through the sapphire glass 34 to realize the detection of the material inside the tank body, and finally reflect the detection result of the material through the spectrum of the material.
- the above-mentioned installation plate 3 is made of stainless steel.
- the temperature of the implementation group can be significantly reduced, and the equipment is carried out During the paste spraying process, the temperature range around the miniature near-infrared probe can be stabilized at 29.1-36.4°C, and during the drying process, the temperature range around the miniature near-infrared probe can be stabilized at 36.4-37.7°C.
- Figure 6 is the spectrogram of the real-time online collection of materials. Figure 6 shows the comparison of the three spectra of continuous scanning for one minute under the control temperature and the uncontrolled temperature. noise, the spectral quality fluctuates greatly, and the quality uniformity is poor, while the spectrum after temperature control has high repeatability and good stability. It is convenient for later data processing and also helps to improve the accuracy of the model.
- the miniature near-infrared probe temperature control device of the above-mentioned embodiment can directly control the external ambient temperature of the miniature near-infrared probe, so that the miniature near-infrared probe can work in a stable specific temperature range, the temperature fluctuation is small, and it will not be affected by excessive ambient temperature. As for the problem that affects the detection accuracy, the cooling control effect is higher.
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Abstract
The present invention relates to a temperature control unit for a mini near-infrared detector and a temperature control method. The temperature control unit comprises a cooling jacket. The cooling jacket is provided with an air inlet where a vortex tube is connected to the cooling jacket. The vortex tube is connected to an air compressor. The cooling jacket is further provided with air exhaust holes. The present invention further provides a temperature control method. The present invention can directly control the ambient temperature of the mini near-infrared detector, such that the mini near-infrared detector can operate in a stable specific temperature range, thus improving the detection accuracy of the mini near-infrared detector.
Description
本发明涉及光谱仪技术领域，尤其是指一种微型近红外探头控温装置以及温度控制方法。The invention relates to the technical field of spectrometers, in particular to a miniature near-infrared probe temperature control device and a temperature control method.
近红外光谱产生于分子振动对光的吸收，主要由分子振动的基态向高能态跃迁产生。近红外光谱不仅携带了结构、官能团等分子本身的特征信息，还包含了诸如氢键等分子内和分子间作用力的信息。然而，这些作用力本身容易受到温度等外界条件的影响。温度的变化会导致分子内和分子间作用力的变化，进而影响分子的振动模式。因此，近红外光谱对温度变化较为敏感，这使得近红外光谱的应用受到了一定限制。The near-infrared spectrum is produced by the absorption of light by molecular vibrations, which is mainly generated by the transition from the ground state of molecular vibrations to high-energy states. Near-infrared spectroscopy not only carries the characteristic information of the molecule itself such as structure and functional group, but also contains information on intramolecular and intermolecular forces such as hydrogen bonds. However, these forces themselves are easily affected by external conditions such as temperature. Changes in temperature cause changes in intra- and intermolecular forces, which in turn affect the vibrational modes of the molecules. Therefore, near-infrared spectroscopy is more sensitive to temperature changes, which limits the application of near-infrared spectroscopy.
近红外光谱分析仪是利用样品对不同波长的近红外光的吸收特性来对样品进行分析的仪器。研究表明，温度的变化会产生振动光谱的偏移，使得特定温度下近红外光谱的测量结果仅适用于该温度下样品的品质分析，一旦近红外光谱分析仪的近红外探头周围的温度偏离特定温度，就会影响样品的品质测量结果。The near-infrared spectrum analyzer is an instrument that uses the absorption characteristics of the sample to near-infrared light of different wavelengths to analyze the sample. Studies have shown that changes in temperature will produce a shift in the vibration spectrum, making the measurement results of near-infrared spectroscopy at a specific temperature only applicable to the quality analysis of samples at this temperature. Once the temperature around the near-infrared probe of the near-infrared spectroscopy analyzer deviates The temperature will affect the quality measurement results of the sample.
为了克服在线应用时温度对光谱的影响，常采用温度修正方法，如化学计量学方法、全局隐含或显式温度补偿、去除对温度敏感的波长等。化学计量学方法适用于含水量较大的样品，具有局限性；全局隐含或温度补偿方法在建模时需要测量不同温度下的光谱及样品实测值，加大了工作量；去除对温度敏感的波长会降低模型的精度。因此，现有的上述方法虽然在特定的条件下可以对温度产生的影响进行修正，但都存在一定的缺陷。In order to overcome the influence of temperature on the spectrum in online applications, temperature correction methods are often used, such as chemometric methods, global implicit or explicit temperature compensation, and removal of temperature-sensitive wavelengths. Chemometric methods are suitable for samples with large water content, which has limitations; global implicit or temperature compensation methods need to measure spectra and sample measured values at different temperatures during modeling, which increases the workload; remove the temperature-sensitive A wavelength that reduces the accuracy of the model. Therefore, although the above-mentioned existing methods can correct the influence of temperature under certain conditions, they all have certain defects.
以制药领域中的一步制粒工段为例，当运行至干燥工序时，样品-物料 温度最高可达到70～75℃，远超过探头的运行温度(-20～40℃，非凝结)，此时，现有的上述温度修正方法已不再适用。Taking the one-step granulation section in the pharmaceutical field as an example, when running to the drying process, the sample-material temperature can reach a maximum of 70-75°C, far exceeding the operating temperature of the probe (-20-40°C, non-condensing). , the existing above-mentioned temperature correction method is no longer applicable.
综上，温度对近红外光谱分析仪的微型近红外探头的测量具有较大的影响，但是现有技术无法通过外部控制方法从根本上消除温度对光谱的影响，微型近红外探头在实际测量时易因周围温度过高而导致检测准确度较差，因此，现有技术无法有效保证微型近红外探头在特定温度区间内稳定工作，无法满足检测需求。In summary, temperature has a great influence on the measurement of the miniature near-infrared probe of the near-infrared spectrum analyzer, but the existing technology cannot fundamentally eliminate the influence of temperature on the spectrum through external control methods. It is easy to cause poor detection accuracy due to high ambient temperature. Therefore, the existing technology cannot effectively guarantee the stable operation of the miniature near-infrared probe in a specific temperature range, and cannot meet the detection requirements.
发明内容Contents of the invention
为此，本发明所要解决的技术问题在于克服现有技术中无法使得微型近红外探头始终在特定温度区间内稳定工作的缺陷。Therefore, the technical problem to be solved by the present invention is to overcome the defect in the prior art that the miniature near-infrared probe cannot always work stably within a specific temperature range.
为解决上述技术问题，本发明提供了一种微型近红外探头控温装置，包括冷却套，所述冷却套上设置有进气口，所述进气口处连接有涡流管，所述涡流管和空气压缩机相连接，所述冷却套上还设置有排气孔。In order to solve the above technical problems, the present invention provides a miniature near-infrared probe temperature control device, including a cooling jacket, an air inlet is arranged on the cooling jacket, a vortex tube is connected to the air inlet, and the vortex tube It is connected with an air compressor, and an exhaust hole is also arranged on the cooling jacket.
在本发明的一个实施例中，所述涡流管和所述进气口通过螺纹连接。In one embodiment of the present invention, the vortex tube and the air inlet are connected by threads.
在本发明的一个实施例中，所述涡流管的中部设置有空气进口，所述涡流管的两端分别为冷空气出口和热空气出口，所述冷空气出口和所述冷却套的所述进气口相连通。In one embodiment of the present invention, the middle part of the vortex tube is provided with an air inlet, and the two ends of the vortex tube are respectively a cold air outlet and a hot air outlet, and the cold air outlet and the cooling jacket The air inlets are connected.
在本发明的一个实施例中，所述冷却套上设置有多个所述排气孔，多个所述排气孔呈矩形阵列或环形阵列排布。In one embodiment of the present invention, the cooling jacket is provided with a plurality of exhaust holes, and the plurality of exhaust holes are arranged in a rectangular array or an annular array.
在本发明的一个实施例中，所述冷却套的外壁向外凸出形成凸块，所述排气孔设置在所述凸块上。In one embodiment of the present invention, the outer wall of the cooling jacket protrudes outward to form a bump, and the exhaust hole is arranged on the bump.
在本发明的一个实施例中，所述排气孔为斜孔。In one embodiment of the present invention, the exhaust holes are oblique holes.
在本发明的一个实施例中，所述排气孔呈圆形或椭圆形。In one embodiment of the present invention, the exhaust holes are circular or oval.
一种利用上述任一项所述的控温装置对微型近红外探头进行温度控制的方法，将微型近红外探头安装在一步制粒机的罐体外壁上，并根据一步制粒机的罐体内部温度来调节空气压缩机输出至涡流管的输出压力而使得红 外探头周围温度得以下降。A method for controlling the temperature of the miniature near-infrared probe using the temperature control device described in any of the above, wherein the miniature near-infrared probe is installed on the outer wall of the tank of the one-step granulator, and according to the tank body of the one-step granulator The internal temperature is used to adjust the output pressure of the air compressor output to the vortex tube so that the temperature around the infrared probe can be reduced.
在本发明的一个实施例中，空气压缩机输出至涡流管的输出压力Pt，由以下公式计算得到：In one embodiment of the present invention, the output pressure Pt of the air compressor output to the vortex tube is calculated by the following formula:
Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst
2+p11*Tst*Trt+p02*Trt
2+p30*Tst
3+p21*Tst
2*Trt+p12*Tst*Trt
2
Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst 2 +p11*Tst*Trt+p02*Trt 2 +p30*Tst 3 +p21*Tst 2 *Trt+p12*Tst *Trt 2
其中，Tst为微型近红外探头的设定温度，Trt为一步制粒机的罐体内部温度，P00、P10、P01、P20、P11、P02、P30、P21和P12均为温度修正系数，P00＝33.97，P10＝-3.485，P01＝0.301，P20＝0.14，P11＝-0.05225，P02＝0.01229，P30＝-0.002042，P21＝0.001384，P12＝-0.0003962。Among them, Tst is the set temperature of the miniature near-infrared probe, Trt is the internal temperature of the tank of the one-step granulator, P00, P10, P01, P20, P11, P02, P30, P21 and P12 are temperature correction coefficients, P00= 33.97, P10=-3.485, P01=0.301, P20=0.14, P11=-0.05225, P02=0.01229, P30=-0.002042, P21=0.001384, P12=-0.0003962.
在本发明的一个实施例中，一步制粒机的罐体上设置有安装孔，所述安装孔上连接有安装板，所述安装板上设置有第一视窗孔和第二视窗孔，所述第一视窗孔处连接透明玻璃，所述第二视窗孔处连接有蓝宝石玻璃，所述微型近红外探头连接在所述第二视窗口外部，微型近红外探头射出的近红外光通过蓝宝石玻璃射入所述一步制粒机的罐体内部。In one embodiment of the present invention, the tank body of the one-step granulator is provided with a mounting hole, the mounting hole is connected with a mounting plate, and the mounting plate is provided with a first window hole and a second window hole, so The first window hole is connected to transparent glass, the second window hole is connected to sapphire glass, the miniature near-infrared probe is connected to the outside of the second window, and the near-infrared light emitted by the miniature near-infrared probe passes through the sapphire glass. Shot into the inside of the tank of the one-step granulator.
本发明的上述技术方案相比现有技术具有以下优点：The above technical solution of the present invention has the following advantages compared with the prior art:
本发明所述的微型近红外探头控温装置及温度控制方法，能够直接控制微型近红外探头外部环境温度，使得微型近红外探头能够在稳定的特定温度范围内工作，不会因周围温度过高而影响检测准确度的问题。The miniature near-infrared probe temperature control device and temperature control method described in the present invention can directly control the external environment temperature of the miniature near-infrared probe, so that the miniature near-infrared probe can work in a stable specific temperature range, and will not be affected by excessive ambient temperature. and affect the detection accuracy.
为了使本发明的内容更容易被清楚的理解，下面根据本发明的具体实施例并结合附图，对本发明作进一步详细的说明。In order to make the content of the present invention more clearly understood, the present invention will be further described in detail below according to the specific embodiments of the present invention and in conjunction with the accompanying drawings.
图1是本发明的微型近红外探头控温装置的结构示意图；Fig. 1 is the structural representation of miniature near-infrared probe temperature control device of the present invention;
图2是图1中冷却套的结构示意图；Fig. 2 is a schematic structural view of the cooling jacket in Fig. 1;
图3是图2中冷却套的剖视图；Fig. 3 is a sectional view of the cooling jacket in Fig. 2;
图4是安装板的结构示意图；Fig. 4 is the structural representation of mounting plate;
图5是实施温度控制和未实施温度控制下的近红外探头温度变化图；Fig. 5 is the near-infrared probe temperature change diagram under the implementation of temperature control and non-implementation of temperature control;
图6是实施温度控制和未实施温度控制下的物料光谱图；Fig. 6 is the material spectrogram under implementing temperature control and not implementing temperature control;
说明书附图标记说明：1、冷却套；11、进气口；12、排气孔；13、凸块；2、涡流管；21、空气进口；22、冷空气出口；23、热空气出口；3、安装板；31、第一视窗孔；32、第二视窗孔；33、透明玻璃；34、蓝宝石玻璃。Explanation of reference signs in the manual: 1. cooling jacket; 11. air inlet; 12. exhaust hole; 13. bump; 2. vortex tube; 21. air inlet; 22. cold air outlet; 23. hot air outlet; 3. Mounting plate; 31. First window hole; 32. Second window hole; 33. Transparent glass; 34. Sapphire glass.
下面结合附图和具体实施例对本发明作进一步说明，以使本领域的技术人员可以更好地理解本发明并能予以实施，但所举实施例不作为对本发明的限定。The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, so that those skilled in the art can better understand the present invention and implement it, but the examples given are not intended to limit the present invention.
参照图1-图3所示，本发明公开了一种微型近红外探头控温装置，包括冷却套1，冷却套1上设置有进气口11，进气口11处连接有涡流管2，涡流管2和空气压缩机相连接，冷却套1上还设置有排气孔12，排气孔12便于气流带走热量，降低探头温度。Referring to Fig. 1-shown in Fig. 3, the present invention discloses a kind of miniature near-infrared probe temperature control device, comprises cooling jacket 1, is provided with air inlet 11 on cooling jacket 1, is connected with vortex tube 2 at air inlet 11, The vortex tube 2 is connected with the air compressor, and the cooling jacket 1 is also provided with an exhaust hole 12, which is convenient for the airflow to take away heat and reduce the temperature of the probe.
使用时，微型近红外探头安装在冷却套1内部，通过涡流管2向冷却套1内部输入冷空气，从而降低微型近红外探头周围的环境温度，使得微型近红外探头始终能够在特定的温度范围内稳定工作，保持其检测准确性。When in use, the miniature near-infrared probe is installed inside the cooling jacket 1, and cold air is input into the inside of the cooling jacket 1 through the vortex tube 2, thereby reducing the ambient temperature around the miniature near-infrared probe, so that the miniature near-infrared probe can always be in a specific temperature range It works stably and maintains its detection accuracy.
另外，采用涡流管2制冷散热，无需运动部件，产生的冷空气最低可达到零下几十度左右，制冷范围较广，且可以迅速产生冷空气，制冷速度较快；整个制冷过程不用电、不用任何化学物质、不会产生电火花，整个过程更加安全，可以有效保证作业安全。In addition, the vortex tube 2 is used for cooling and heat dissipation, without moving parts, and the cold air generated can be as low as tens of degrees below zero. The cooling range is wide, and cold air can be generated quickly, and the cooling speed is fast; No chemical substances are used, no electric sparks are generated, the whole process is safer, and the operation safety can be effectively guaranteed.
上述结构是通过气冷实现降温，相较于水冷需布置复杂管道来说，气冷结构更加简单，便于布置。The above structure achieves cooling through air cooling. Compared with water cooling, which needs to arrange complex pipelines, the air cooling structure is simpler and easier to arrange.
进一步，上述排气孔12和进气口11分别位于冷却套1两侧，呈相对设置。Further, the above-mentioned exhaust holes 12 and air inlets 11 are respectively located on both sides of the cooling jacket 1 and are oppositely arranged.
另外，冷却套1可采用导热性较好的材质进行制造，以进一步加强散热 效果。In addition, the cooling jacket 1 can be made of a material with better thermal conductivity to further enhance the heat dissipation effect.
在其中一个实施方式中，涡流管2和进气口11通过螺纹连接，连接可靠，且便于安装和维护。In one of the embodiments, the vortex tube 2 and the air inlet 11 are connected by threads, the connection is reliable, and the installation and maintenance are convenient.
为保证连接气密性，涡流管2和进气口11之间可设置密封圈。In order to ensure the air tightness of the connection, a sealing ring can be arranged between the vortex tube 2 and the air inlet 11 .
在其中一个实施方式中，涡流管2的中部设置有空气进口21，空气压缩机输出的压缩空气从空气进口21进入涡流管2，涡流管2的两端分别为冷空气出口22和热空气出口23，冷空气出口22和冷却套1的进气口11相连通，以使得涡流管2的冷空气出口22输出的冷空气经由进气口11进入冷却套1内部，从而实现对冷却套1内部环境进行降温的作用。In one of the embodiments, the middle part of the vortex tube 2 is provided with an air inlet 21, the compressed air output by the air compressor enters the vortex tube 2 from the air inlet 21, and the two ends of the vortex tube 2 are cold air outlet 22 and hot air outlet respectively 23. The cold air outlet 22 communicates with the air inlet 11 of the cooling jacket 1, so that the cold air output by the cold air outlet 22 of the vortex tube 2 enters the inside of the cooling jacket 1 through the air inlet 11, thereby realizing the cooling of the inside of the cooling jacket 1. environment to cool down.
在其中一个实施方式中，冷却套1上设置有多个排气孔12，多个排气孔12呈矩形阵列或环形阵列排布，以加强空气流动性，加速热量散失。In one embodiment, the cooling jacket 1 is provided with a plurality of exhaust holes 12 arranged in a rectangular array or an annular array to enhance air flow and accelerate heat dissipation.
在其中一个实施方式中，冷却套1的外壁向外凸出形成凸块13，排气孔12设置在凸块13上。通过凸块13的设置可以增强冷却套1的强度，防止排气孔12所在区域因长期使用发生变形。In one embodiment, the outer wall of the cooling jacket 1 protrudes outward to form a bump 13 , and the exhaust hole 12 is disposed on the bump 13 . The strength of the cooling jacket 1 can be enhanced through the arrangement of the protrusions 13, and the deformation of the area where the exhaust hole 12 is located can be prevented from being deformed due to long-term use.
在其中一个实施方式中，排气孔12为斜孔，以更好地保证空气流动效果。In one embodiment, the exhaust holes 12 are oblique holes to better ensure the air flow effect.
在其中一个实施方式中，排气孔12呈圆形或椭圆形，但不限于上述形状，也可以是其他形状。In one embodiment, the exhaust hole 12 is circular or elliptical, but not limited to the above-mentioned shapes, and may also be other shapes.
在其中一个实施方式中，空气压缩机的空气压力范围为0.1MPa～0.7MPa，根据不同的设备或者不同的工序运行情况进行调整。In one embodiment, the air pressure of the air compressor ranges from 0.1 MPa to 0.7 MPa, which is adjusted according to different equipment or operating conditions of different processes.
一步制粒机是医药领域常用的设备，用于使得药物粉末凝成疏松的小颗粒并进行干燥，最终形成理想的均匀的多微孔球状颗粒，在一步制粒机的罐体中可以一次完成混合、造粒和干燥三个工序。The one-step granulator is a commonly used equipment in the medical field. It is used to condense the drug powder into loose small particles and dry them, and finally form ideal uniform microporous spherical particles. It can be completed in one step in the tank of the one-step granulator. Three processes of mixing, granulating and drying.
以一步制粒机为例，本实施例还公开了一种利用上述控温装置对微型近 红外探头进行温度控制的方法，将微型近红外探头安装在一步制粒机的罐体外壁上，并根据一步制粒机的罐体内部温度来调节空气压缩机输出至涡流管2的输出压力而使得红外探头周围温度得以下降。Taking the one-step granulator as an example, this embodiment also discloses a method for controlling the temperature of the miniature near-infrared probe by using the above-mentioned temperature control device. The miniature near-infrared probe is installed on the outer wall of the tank of the one-step granulator, and Adjust the output pressure of the air compressor to the vortex tube 2 according to the internal temperature of the tank of the one-step granulator so that the temperature around the infrared probe can be reduced.
进一步地，空气压缩机输出至涡流管2的输出压力，由以下公式计算得到：Further, the output pressure of the air compressor output to the vortex tube 2 is calculated by the following formula:
Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst
2+p11*Tst*Trt+p02*Trt
2+p30*Tst
3+p21*Tst
2*Trt+p12*Tst*Trt
2
Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst 2 +p11*Tst*Trt+p02*Trt 2 +p30*Tst 3 +p21*Tst 2 *Trt+p12*Tst *Trt 2
其中，Tst为微型近红外探头的设定温度，Trt为一步制粒机的罐体内部温度，P00、P10、P01、P20、P11、P02、P30、P21和P12均为温度修正系数，P00＝33.97，P10＝-3.485，P01＝0.301，P20＝0.14，P11＝-0.05225，P02＝0.01229，P30＝-0.002042，P21＝0.001384，P12＝-0.0003962。Among them, Tst is the set temperature of the miniature near-infrared probe, Trt is the internal temperature of the tank of the one-step granulator, P00, P10, P01, P20, P11, P02, P30, P21 and P12 are temperature correction coefficients, P00= 33.97, P10=-3.485, P01=0.301, P20=0.14, P11=-0.05225, P02=0.01229, P30=-0.002042, P21=0.001384, P12=-0.0003962.
上述公式通过制粒机罐体内腔温度来调节空气压缩机输出的空气压力，能够更加准确地控制降温效果，保证近红外探头设备能够稳定在特定的温度范围内正常工作。实际过程中，可以将制粒机罐体内腔温度传输至中控主机，当工艺调节时，或者物料实时状态发生改变时，中空主机就可以根据制粒机罐体内温度调节压缩空气的压力，从而进行对近红外探头设备进行整体降温。The above formula adjusts the air pressure output by the air compressor through the temperature of the inner cavity of the granulator tank, which can more accurately control the cooling effect and ensure that the near-infrared probe equipment can work normally within a specific temperature range. In the actual process, the temperature of the inner cavity of the granulator tank can be transmitted to the central control host. When the process is adjusted or the real-time state of the material changes, the hollow host can adjust the pressure of the compressed air according to the temperature inside the granulator tank, thereby Carry out overall cooling of the near-infrared probe equipment.
在其中一个实施方式中，一步制粒机的罐体上设置有安装孔，安装孔上连接有安装板3，其结构如图4所示，安装板3上设置有第一视窗孔31和第二视窗孔32，第一视窗孔31处连接有透明玻璃33，例如钢化玻璃，第二视窗孔32处连接有蓝宝石玻璃34，微型近红外探头连接在第二视窗口外部，微型近红外探头射出的近红外光通过蓝宝石玻璃34射入一步制粒机的罐体内部，以实现对罐体内部物料的检测，最终通过物料的光谱图来反映物料的检测结果。In one of the embodiments, the tank body of the one-step granulator is provided with a mounting hole, and a mounting plate 3 is connected to the mounting hole. Two window holes 32, the first window hole 31 is connected with transparent glass 33, such as toughened glass, the second window hole 32 is connected with sapphire glass 34, the miniature near-infrared probe is connected outside the second window, and the miniature near-infrared probe emits The near-infrared light is injected into the tank body of the one-step granulator through the sapphire glass 34 to realize the detection of the material inside the tank body, and finally reflect the detection result of the material through the spectrum of the material.
在其中一个实施方式中，上述安装板3采用不锈钢板。In one embodiment, the above-mentioned installation plate 3 is made of stainless steel.
以下述参数进行设置：设置近红外光谱分析仪的扫描参数，积分时间 10.3ms，扫描次数100次，扫描间隔为20s，波长范围908nm-1676nm；制粒机设备运行喷膏工序，空气压缩机供气压力为0.15MPa，时间为58min；制粒机设备运行干燥工序，空气压缩机供气压力为0.4MPa，时间为30min。由图5-图6可见，图5中实施组为实行上述实施例的温度控制方法的方式，对照组为未采用温度控制的方式，由图5可知，实施组的温度得以明显下降，设备进行喷膏工序时，微型近红外探头周围温度范围可以稳定在29.1～36.4℃，干燥工序时，微型近红外探头周围温度范围可以稳定在36.4～37.7℃。图6为实时在线采集物料的光谱图，图6中显示了控制温度下与未控制温度下，连续扫描一分钟的三张光谱比较情况，由图6可知，未控制温度的光谱明细有较大的噪声，光谱质量波动较大，质量均一性较差，而经过控制温度的光谱重复性较高，稳定性好，达到了在线检测光谱质量的水平，其光谱图的质量明显得到了提高，既便于后期数据处理，也利于提高模型的精确度。Set the following parameters: set the scanning parameters of the near-infrared spectrum analyzer, the integration time is 10.3ms, the number of scans is 100 times, the scanning interval is 20s, and the wavelength range is 908nm-1676nm; the granulator equipment runs the paste spraying process, and the air compressor supplies The air pressure is 0.15MPa, and the time is 58min; the granulator equipment runs the drying process, and the air supply pressure of the air compressor is 0.4MPa, and the time is 30min. As can be seen from Fig. 5-Fig. 6, the implementation group in Fig. 5 is the mode of implementing the temperature control method of the above-mentioned embodiment, and the control group is the mode of not adopting temperature control. As can be seen from Fig. 5, the temperature of the implementation group can be significantly reduced, and the equipment is carried out During the paste spraying process, the temperature range around the miniature near-infrared probe can be stabilized at 29.1-36.4°C, and during the drying process, the temperature range around the miniature near-infrared probe can be stabilized at 36.4-37.7°C. Figure 6 is the spectrogram of the real-time online collection of materials. Figure 6 shows the comparison of the three spectra of continuous scanning for one minute under the control temperature and the uncontrolled temperature. noise, the spectral quality fluctuates greatly, and the quality uniformity is poor, while the spectrum after temperature control has high repeatability and good stability. It is convenient for later data processing and also helps to improve the accuracy of the model.
上述实施例的微型近红外探头控温装置，能够直接控制微型近红外探头外部环境温度，使得微型近红外探头能够在稳定的特定温度范围内工作，温度波动较小，不会因周围温度过高而影响检测准确度的问题，降温控制效果较高。The miniature near-infrared probe temperature control device of the above-mentioned embodiment can directly control the external ambient temperature of the miniature near-infrared probe, so that the miniature near-infrared probe can work in a stable specific temperature range, the temperature fluctuation is small, and it will not be affected by excessive ambient temperature. As for the problem that affects the detection accuracy, the cooling control effect is higher.
显然，上述实施例仅仅是为清楚地说明所作的举例，并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引申出的显而易见的变化或变动仍处于本发明创造的保护范围之中。Apparently, the above-mentioned embodiments are only examples for clear description, and are not intended to limit the implementation. For those of ordinary skill in the art, on the basis of the above description, other changes or changes in various forms can also be made. It is not necessary and impossible to exhaustively list all the implementation manners here. However, the obvious changes or changes derived therefrom are still within the scope of protection of the present invention.
Claims (10)
- 一种微型近红外探头控温装置，其特征在于：包括冷却套，所述冷却套上设置有进气口，所述进气口处连接有涡流管，所述涡流管和空气压缩机相连接，所述冷却套上还设置有排气孔。A miniature near-infrared probe temperature control device, characterized in that it includes a cooling jacket, an air inlet is arranged on the cooling jacket, a vortex tube is connected to the air inlet, and the vortex tube is connected to an air compressor , the cooling jacket is also provided with exhaust holes.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述涡流管和所述进气口通过螺纹连接。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the vortex tube and the air inlet are connected by threads.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述涡流管的中部设置有空气进口，所述涡流管的两端分别为冷空气出口和热空气出口，所述冷空气出口和所述冷却套的所述进气口相连通。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the middle part of the vortex tube is provided with an air inlet, and the two ends of the vortex tube are respectively a cold air outlet and a hot air outlet, and the cold air The air outlet communicates with the air inlet of the cooling jacket.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述冷却套上设置有多个所述排气孔，多个所述排气孔呈矩形阵列或环形阵列排布。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the cooling jacket is provided with a plurality of exhaust holes, and the plurality of exhaust holes are arranged in a rectangular array or an annular array.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述冷却套的外壁向外凸出形成凸块，所述排气孔设置在所述凸块上。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the outer wall of the cooling jacket protrudes outward to form a bump, and the exhaust hole is arranged on the bump.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述排气孔为斜孔。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the exhaust hole is an oblique hole.
- 根据权利要求1所述的微型近红外探头控温装置，其特征在于：所述排气孔呈圆形或椭圆形。The miniature near-infrared probe temperature control device according to claim 1, characterized in that: the exhaust hole is circular or oval.
- 一种利用如权利要求1-7任一项所述的控温装置对微型近红外探头进行温度控制的方法，其特征在于：将所述微型近红外探头安装在一步制粒机的罐体外壁上，并根据一步制粒机的罐体内部温度来调节空气压缩机输出至涡流管的输出压力而使得红外探头周围温度得以下降。A method for controlling the temperature of the miniature near-infrared probe using the temperature control device as claimed in any one of claims 1-7, characterized in that: the miniature near-infrared probe is installed on the outer wall of the tank of the one-step granulator According to the internal temperature of the tank of the one-step granulator, the output pressure of the air compressor to the vortex tube is adjusted to reduce the temperature around the infrared probe.
- 根据权利要求8所述的对微型近红外探头进行温度控制的方法，其 特征在于：空气压缩机输出至涡流管的输出压力Pt，由以下公式计算得到：The method for carrying out temperature control to the miniature near-infrared probe according to claim 8, is characterized in that: the output pressure Pt of air compressor output to vortex tube is calculated by following formula:Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst 2+p11*Tst*Trt+p02*Trt 2+p30*Tst 3+p21*Tst 2*Trt+p12*Tst*Trt 2 Pt＝F(Tst,Trt)＝p00+p10*Tst+p01*Trt+p20*Tst 2 +p11*Tst*Trt+p02*Trt 2 +p30*Tst 3 +p21*Tst 2 *Trt+p12*Tst *Trt 2其中，Tst为微型近红外探头的设定温度，Trt为一步制粒机的罐体内部温度，P00、P10、P01、P20、P11、P02、P30、P21和P12均为温度修正系数，P00＝33.97，P10＝-3.485，P01＝0.301，P20＝0.14，P11＝-0.05225，P02＝0.01229，P30＝-0.002042，P21＝0.001384，P12＝-0.0003962。Among them, Tst is the set temperature of the miniature near-infrared probe, Trt is the internal temperature of the tank of the one-step granulator, P00, P10, P01, P20, P11, P02, P30, P21 and P12 are temperature correction coefficients, P00= 33.97, P10=-3.485, P01=0.301, P20=0.14, P11=-0.05225, P02=0.01229, P30=-0.002042, P21=0.001384, P12=-0.0003962.
- 根据权利要求8所述的对微型近红外探头进行温度控制的方法，其特征在于：所述一步制粒机的罐体上设置有安装孔，所述安装孔上连接有安装板，所述安装板上设置有第一视窗孔和第二视窗孔，所述第一视窗孔处连接透明玻璃，所述第二视窗孔处连接有蓝宝石玻璃，所述微型近红外探头连接在所述第二视窗口外部，微型近红外探头射出的近红外光通过蓝宝石玻璃射入所述一步制粒机的罐体内部。The method for controlling the temperature of a miniature near-infrared probe according to claim 8, characterized in that: the tank body of the one-step granulator is provided with a mounting hole, and a mounting plate is connected to the mounting hole, and the mounting The board is provided with a first window hole and a second window hole, the first window hole is connected with transparent glass, the second window hole is connected with sapphire glass, and the miniature near-infrared probe is connected with the second window hole. Outside the window, the near-infrared light emitted by the miniature near-infrared probe is injected into the tank of the one-step granulator through the sapphire glass.
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