WO2023120058A1

WO2023120058A1 - Oral composition

Info

Publication number: WO2023120058A1
Application number: PCT/JP2022/043917
Authority: WO
Inventors: 彩佳岩崎; 友一小熊
Original assignee: ライオン株式会社
Priority date: 2021-12-21
Filing date: 2022-11-29
Publication date: 2023-06-29

Abstract

Provided is an oral composition with which there is achieved exceptional fluorine ion retention in the oral cavity, particularly on the surface of teeth.　An oral composition containing: (A) condensed phosphoric acid or a salt thereof; (B) a calcium salt; (C) a fluorine-containing compound; and (D) at least one substance selected from cysteine, polyvinylpyrrolidone, and collagen compounds.

Description

oral composition

The present invention relates to an oral composition that is excellent in retention of fluoride ions in the oral cavity, particularly on tooth surfaces.

Fluorine-containing compounds such as sodium fluoride are widely used in oral compositions such as dentifrice compositions for the purpose of preventing dental caries as medicinal ingredients having functions such as promoting remineralization and inhibiting demineralization. . In order for fluorine-containing compounds to work effectively, it is effective to retain fluoride ions in the oral mucosa and tooth surfaces. It is desirable to retain a large amount of fluorine ions inside.

As a method for improving retention of fluoride ions, a method of coexisting calcium ions and fluoride ions has been adopted, but calcium ions and fluoride ions are highly reactive, and when they coexist, they act on teeth. Previously, it turned into calcium fluoride, which is an insoluble substance, and sufficient effects were not exhibited.
Patent Document 1 (Japanese Patent Publication No. 10-511956) proposes a method of mixing calcium ions and fluoride ions immediately before application to the oral cavity. Since it enters the oral cavity, it is immediately washed away by saliva and does not exhibit a sufficient retention effect.In addition, calcium fluoride precipitates in a short time after mixing the two components, so the fluoride ion is not released sufficiently and the effect is exhibited. I didn't.
Patent Document 2 (Japanese Patent Application Laid-Open No. 2009-137863) proposes a composition in which a complex of polyphosphate, calcium salt, and fluoride salt is prepared in advance. It's far from perfect, and there is still room for improvement.
Further, Patent Document 3 (International Publication No. 2013/47826) discloses an oral composition containing a lactam compound having a lactam skeleton such as pyrrolidonecarboxylic acid or a salt thereof and having an acidic group, and a fluorine compound. , proposed that it has an excellent dentin caries inhibitory effect. Patent Document 4 (Japanese Patent Application Laid-Open No. 2017-48162) proposes an oral composition having an improved dentin caries inhibitory effect, which contains a lactam compound and a water-insoluble calcium salt having a predetermined average particle size. there is However, these are all limited to effects on dentin, and there is still room for improvement with respect to retention of fluoride ions on tooth surfaces.

Japanese Patent Publication No. 10-511956 JP 2009-137863 A WO2013/47826 JP 2017-48162 A Japanese Patent Application Laid-Open No. 2021-95380

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an oral composition that is excellent in retention of fluoride ions in the oral cavity, particularly on tooth surfaces.

As a result of intensive studies to achieve the above object, the present inventors found that (A) condensed phosphoric acid or its salt, (B) calcium salt, (C) fluorine-containing compound, and (D) cysteine and polyvinylpyrrolidone and a collagen compound in an oral composition increases the retention of fluoride ions in the oral cavity, particularly on the tooth surface, and can provide excellent retention of fluoride ions. I came to make

In the present invention, in an oral composition such as a dentifrice, when the component (C) is combined with the components (A) and (B), a complex is formed by these to form a fluoride which is an insoluble substance. The formation of calcium chloride is prevented, the release of fluoride ions is improved, the adsorption of fluoride ions to the tooth surface (enamel) is increased, and by adding component (D), component (D) is reduced. It has a unique effect of further improving the adsorption of fluoride ions to the tooth surface, thereby remarkably improving the retention of fluoride ions and providing excellent retention of fluoride ions.
The effects of the present invention can be obtained by combining component (D) with components (A), (B) and (C). As shown in Examples and Comparative Examples described later, oral compositions (Examples) obtained by combining components (A), (B) and (C) of the present invention with component (D) are blended into tooth surfaces. The retention of fluorine ions on the tooth surface was higher than that of Comparative Example 2 in which component (D) was not blended.
In addition, Patent Document 5 (Japanese Patent Application Laid-Open No. 2021-95380) describes fluoride ion retention and release in the oral mucosa by a combination of tripolyphosphate or pyrophosphate, water-soluble calcium salt, sodium fluoride, and cationized cellulose. improvement in sexuality. In contrast, the present invention is a combination of components (A), (B), (C) and (D), and the component (D) exerts a specific and unexpected action, thereby It improves the retention of fluoride ions and provides an excellent effect of retention of fluoride ions.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) condensed phosphoric acid or a salt thereof;
(B) a calcium salt;
An oral composition comprising (C) a fluorine-containing compound and (D) one or more selected from cysteine, polyvinylpyrrolidone and a collagen compound.
[2]
(A) The oral composition according to [1], wherein the condensed phosphoric acid or its salt is one or more selected from pyrophosphate, tripolyphosphate and metaphosphate.
[3]
(A) The oral composition according to [2], wherein the condensed phosphoric acid or its salt is potassium pyrophosphate.
[4]
(B) The oral composition according to any one of [1] to [3], wherein the calcium salt is one or more selected from calcium glycerophosphate and calcium chloride.
[5]
(C) The oral composition according to any one of [1] to [4], wherein the fluorine-containing compound is one or more selected from sodium fluoride, sodium monofluorophosphate and tin fluoride.
[6]
The oral cavity use according to any one of [1] to [5], wherein (A)/(C) is 0.05 to 1 as a molar ratio and (B)/(C) is 0.1 to 2 as a molar ratio. Composition.
[7]
The oral composition according to any one of [1] to [6], wherein the content of component (C) is 500 to 5,000 ppm as fluorine ions.
[8]
The content of component (A) is 0.1 to 1.5% by mass, the content of component (B) is 0.1 to 2% by mass, and the content of component (D) is 0.01 to 10% by mass. A composition for oral cavity according to any one of [1] to [7].
[9]
The oral composition according to any one of [1] to [8], which is a dentifrice composition.

According to the present invention, it is possible to provide an oral composition that is excellent in retention of fluoride ions on tooth surfaces in the oral cavity. Since the oral cavity composition of the present invention is excellent in retention of fluoride ions on the tooth surface, a relatively large amount of fluoride ions are retained in the oral cavity, thereby promoting remineralization and demineralization of the component (C). It is possible to sufficiently exert effects such as suppression, and it is effective for caries prevention.

The present invention will be described in further detail below.
The oral composition of the present invention contains one or more selected from (A) condensed phosphoric acid or its salt, (B) calcium salt, (C) fluorine-containing compound, and (D) cysteine, polyvinylpyrrolidone and collagen compound. contains.

(A) Condensed phosphoric acid or a salt thereof has the effect of improving retention of fluoride ions on tooth surfaces.
Water-soluble condensed phosphoric acid or a salt thereof (solubility in water at 20° C.; 1 g/100 g or more) can be preferably used as condensed phosphoric acid or a salt thereof. Component (A) includes, for example, linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid and tetrapolyphosphoric acid or salts thereof, and cyclic polyphosphoric acids such as trimetaphosphoric acid, tetrametaphosphoric acid and hexametaphosphoric acid or salts thereof. . Salts include alkali metal salts such as sodium salts and potassium salts. Among these, pyrophosphates, tripolyphosphates and metaphosphates are preferred, and pyrophosphates and tripolyphosphates are more preferred, from the viewpoint of improving the retention of fluorine ions.
Specific examples of condensed phosphoric acid or salts thereof include potassium pyrophosphate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, etc. Potassium pyrophosphate is particularly preferred.
These may be used singly or in combination of two or more, and commercially available products can be used.

(A) The amount of condensed phosphoric acid or its salt is preferably 0.1 to 1.5% (% by mass, the same shall apply hereinafter) of the entire composition, more preferably 0.15 to 1.4%, and still more preferably is 0.2 to 1.0%. When the compounding amount is 0.1% or more, the retention of fluoride ions is sufficiently improved, and the retention of fluoride ions on the tooth surface is excellent. When it is 1.5% or less, the retention of fluorine ions is sufficiently maintained.

(B) Calcium salt has the effect of improving retention of fluoride ions on the tooth surface.
A calcium salt having a solubility in water at 20° C. of 0.5 g/100 g or more can be preferably used. For example calcium glycerophosphate, calcium chloride, calcium nitrate, calcium acetate, calcium citrate, calcium gluconate, calcium benzoate, calcium formate, calcium fumarate, calcium lactate, calcium butyrate, calcium isobutyrate, calcium malate, calcium maleate, Calcium propionate, calcium valerate and the like can be mentioned. Among these, calcium glycerophosphate and calcium chloride are preferable from the viewpoint of improving the retention of fluorine ions.
These may be used singly or in combination of two or more, and commercially available products can be used.

(B) The content of calcium salt is preferably 0.1 to 2%, more preferably 0.1 to 1.5%, and still more preferably 0.2 to 1% of the total composition. When the compounding amount is 0.1% or more, the retention of fluoride ions is sufficiently improved, and the retention of fluoride ions on the tooth surface is excellent. When it is 2% or less, the retention of fluorine ions is sufficiently maintained.

(C) As the fluorine-containing compound, sodium fluoride, sodium monofluorophosphate, tin fluoride, and the like can be used. Among these, sodium fluoride is particularly preferred from the viewpoint of improving retention of fluoride ions on the tooth surface.
These may be used singly or in combination of two or more, and commercially available products can be used.

(C) The content of the fluorine-containing compound is preferably 500 to 5,000 ppm, more preferably 1,100 to 3,000 ppm, in terms of fluorine ions, based on the total composition. When the content is 500 ppm or more in terms of fluoride ions, retention of fluoride ions can be sufficiently improved, and when it is 5,000 ppm or less, adverse effects such as mottled teeth due to overdose can be prevented.
The blending amount of the fluorine-containing compound varies depending on the amount of fluoride ions to be supplied. For example, in the case of sodium fluoride, when the amount of fluoride ions to be supplied is 500 ppm, the amount to be blended is 0.11% of the total composition. Specifically, the content of sodium fluoride is preferably 0.11 to 1.1%, more preferably 0.25 to 0.7% of the total composition.

In the present invention, (A)/(C), which indicates the quantitative ratio of component (A) and component (C), is preferably 0.05 to 1, more preferably 0.1 to 0.5 as a molar ratio. be.
Also, (B)/(C), which indicates the quantitative ratio of component (B) to component (C), is preferably 0.1-2, more preferably 0.2-1 as a molar ratio.
More preferably, the molar ratio of (A)/(C) and the molar ratio of (B)/(C) are within the above ranges. When the component (C) is blended within these molar ratio ranges, the retention of fluorine ions on the tooth surface is more excellent.

Component (D) is selected from cysteine, polyvinylpyrrolidone and collagen compounds, and one of these can be used alone or two or more of them can be used in combination. Component (D), in combination with components (A), (B) and (C), further enhances retention of fluoride ions on the tooth surface, and exerts an effect of imparting remarkable retention.
As the component (D), polyvinylpyrrolidone is preferable from the viewpoint of improving retention of fluorine ions on the tooth surface.

Cysteine includes L-cysteine, D-cysteine, DL-cysteine, and salts and hydrates such as hydrochlorides thereof (eg, cysteine hydrochloride, cysteine hydrochloride hydrate). These can be used individually by 1 type or in combination of 2 or more types. Among them, L-cysteine is preferable from the viewpoint of improving retention of fluoride ions on the tooth surface.
Cysteine may be derived from natural products such as animals and plants, may be chemically synthesized, or may be commercially available. Co., Ltd.) and the like can be used.

Polyvinylpyrrolidone preferably has a K value of 25 to 95, more preferably 25 to 50. Various grades can be used as long as the effects of the present invention are not impaired, and commercially available products are used. You can also
The above K value is a value determined by the method described in the Japanese Pharmacopoeia, 18th Edition, Articles "Povidone".
Examples of such polyvinylpyrrolidone include polyvinylpyrrolidone K25, polyvinylpyrrolidone K30, polyvinylpyrrolidone K60, polyvinylpyrrolidone K90, and the like. These can be used individually by 1 type or in combination of 2 or more types.
Polyvinylpyrrolidone is a commercial product, specifically, Plasdone K-25, Plasdone K-90, Plasdone K-90D, Plasdone K-90M, Plasdone K-29/32 (all manufactured by ISP), Rubis Koll K-30, Kollidon 12PF, Kollidon 17PF, Kollidon 25, Kollidon 30, Kollidon 90F (all manufactured by BASF) and the like can be used.

Collagen compounds include water-soluble collagen, insoluble collagen, hydrolysates thereof, derivatives thereof, and salts thereof. These can be used individually by 1 type or in combination of 2 or more types.
Specifically, water-soluble collagen and insoluble collagen extracted and purified from mammals, birds, and fish can be used, and atelocollagen and hydrolyzed collagen peptide obtained by enzymatic treatment and hydrolysis thereof can also be used. . Furthermore, derivatives obtained by adding fatty acids and the like to these collagen compounds can also be used. Among them, hydrolyzed collagen peptide is preferable from the viewpoint of improving the retention of fluoride ions on the tooth surface.
The collagen compound preferably has a weight average molecular weight of 100 to 9,000 (measured by the average molecular weight measurement method described in Photographic Gelatin Test Method (PAGI Method) 10th Edition).
As the collagen compound, "hydrolyzed collagen powder" described in the Standards for Quasi-drug Ingredients 2021 can be used, and commercially available products can also be used. Specifically, HACP-U2 (manufactured by Zerais Co., Ltd.) and the like can be used as the hydrolyzed collagen peptide.

The amount of component (D) to be blended is preferably 0.01 to 10% of the total composition. When the compounding amount is 0.01% or more, the retention of fluorine ions is sufficiently improved, and the retention of fluorine ions on the tooth surface is excellent. When it is 10% or less, the retention of fluorine ions is sufficiently maintained.
Furthermore, when cysteine is blended as component (D), the blending amount is preferably 0.1 to 3%, more preferably 0.2 to 2%, still more preferably 0.5 to 1.0% of the total composition. 5%.
When polyvinylpyrrolidone is blended as the component (D), its blending amount is preferably 0.01 to 5%, more preferably 0.02 to 2%, and still more preferably 0.04 to 1.5% of the total composition. %.
When a collagen compound is blended as component (D), its blending amount is preferably 0.1 to 10%, more preferably 0.5 to 8%, and still more preferably 1 to 5% of the total composition.

The oral composition of the present invention may be in the form of paste, gel or liquid, particularly paste or liquid, and may be used in dentifrices such as toothpaste, gel toothpaste, liquid dentifrice and wet toothpaste, and cleansers. It can be used after being prepared as oral agents, mouthwashes, mouthsprays, and the like. A dentifrice composition is particularly preferable, and is suitable as a dentifrice such as a toothpaste.
As a preparation method, a conventional method can be adopted depending on the form and dosage form. A dentifrice composition can be prepared by a known method, for example, by blending components (A) to (D), water, and optional ingredients in a conventional manner.
In this case, in addition to the components described above, other optional components can be blended as necessary depending on the purpose, dosage form, etc. of the oral composition. Optional ingredients include, for example, surfactants, abrasives, thickeners, wetting agents, sweetening agents, flavoring agents, preservatives, coloring agents, active ingredients, solvents and the like.
Specific examples of optional components are shown below. These optional components can be blended singly or in combination of two or more, and the blending amount of each optional component can be a normal amount within a range that does not impair the effects of the present invention.

Surfactant:
Examples of surfactants include anionic surfactants, nonionic surfactants, and amphoteric surfactants, and specific examples are shown in (i) to (iii) below.
(i) Anionic Surfactants Alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acylmethyl taurine salts, acyl glutamates, and α-olefin sulfonates (tetradecene sulfonates) can be mentioned. As the above salt, alkali metal salts such as sodium salts and potassium salts are preferable.
(ii) Nonionic Surfactant Polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, fatty acid monoglyceride.
(iii) Amphoteric Surfactant Fatty acid amidopropyl betaine such as coconut oil fatty acid amidopropyl betaine, and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salt.
The surfactant content is preferably 0.001 to 10%, more preferably 0.1 to 5%, of the total composition.

Abrasive:
Examples include silica-based abrasives such as silicic anhydride, zeolite, and aluminum hydroxide. The amount of abrasive compounded is usually 2 to 50%, particularly 10 to 40%, of the total composition.

Thickener:
Organic thickeners such as xanthan gum, sodium alginate, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, cationized cellulose and carboxyvinyl polymer, and inorganic thickeners such as thickening silica. The blending amount of the thickener is usually 0.1-10%, particularly 0.1-8% of the total composition.

Wetting agent:
Examples include sugar alcohols such as sorbitol, xylitol and erythritol, and polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycol (PEG). The humectant content is usually 2-50% of the total composition.

Sweetener:
Saccharin, sodium saccharin, sucralose.

Fragrance:
Menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyllinalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil , rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, etc. These can be used alone or in combination of two or more. The amount of perfume compounded is usually 0.01 to 2% of the total composition.

Preservative:
paraoxybenzoic acid ester, sodium benzoate, and the like.
Colorant:
Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, mica titanium and the like.

Optional Active Ingredients:
Enzymes such as dextranase, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, zeolite, aluminum lactate, potassium nitrate, oak extract is mentioned. The amount of these active ingredients to be blended can be an effective amount within a range that does not impair the effects of the present invention.

solvent:
Lower monohydric alcohols having 2 or 3 carbon atoms such as purified water and ethanol can be used. Ethanol, when blended, may be 25% or less of the total composition, or may not be blended.

Examples, Comparative Examples, and Formulation Examples are shown below to specifically describe the present invention, but the present invention is not limited to the following Examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
A dentifrice composition (toothpaste) having the composition shown in Tables 1 and 2 was prepared by a conventional method and evaluated by the following methods. The results are also shown in the table.

Method for evaluating retention of fluoride ions on tooth surface A dentifrice composition diluted 4-fold with purified water was allowed to act on a hydroxyapatite (HA) disk (diameter 7 mm, thickness 3.5 mm, manufactured by PENTAX) for 3 minutes. was immediately washed with purified water. After drying the HA disc, the upper surface of the HA disc was decalcified with 120 μL of 0.1 N HCl for 2 minutes to extract the fluoride ions, and the fluoride ions contained in the solution were measured using an ion meter (Orion 1115000 4-Star, Thermo Fisher). Scientific Co., Ltd.) to determine the fluorine ion concentration (ppm) (average value of N=3) and standard deviation.
Those with an average fluoride ion concentration of 1.6 ppm or more were judged to have improved retention of fluoride ions on the tooth surface and high retention of fluoride ions.

Details of raw materials used are shown below.
(A) Potassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. (B) Calcium glycerophosphate: manufactured by Iwaki Seika Co., Ltd. (B) Calcium chloride manufactured by Kanto Chemical Industry Co., Ltd. (C) Sodium fluoride: Stella Chemifa Co., Ltd. ) (D) L-Cysteine: L-Cysteine, Tokyo Chemical Industry Co., Ltd. (D) Polyvinylpyrrolidone: Rubiscol K-30, BASF K value ^* 26 to 34
*: Determined by the method described in the Japanese Pharmacopoeia, 18th Edition, Articles "Povidone".
(D) Collagen compound: HACP-U2, manufactured by Zerais Co., Ltd. Weight average molecular weight ^** 1,500
**: Measured by the average molecular weight measurement method described in Photographic Gelatin Test Method (PAGI Method) 10th edition.

In addition, prescription examples 1 to 3 are shown.

[Prescription example 1]
(A) potassium pyrophosphate 0.5
(B) Calcium chloride 0.2
(C) sodium fluoride 0.32
(D) L-cysteine 1
Silicic anhydride (abrasive silica) 7
Sorbit solution (70% aqueous solution) 30
Propylene glycol 3
Xanthan gum 0.6
Sodium polyacrylate 0.6
Silicic anhydride (thickening silica) 4
Xylit 2.5
Sodium lauryl sulfate 0.4
Titanium oxide 0.4
Coconut fatty acid amidopropyl betaine 0.2
Hydroxyethyl cellulose dimethyl diallyl ammonium chloride 0.05
Saccharin sodium 0.1
Perfume 0.6
Purified water residue
Total 100.0%
(A)/(C) (molar ratio): 0.20
(B)/(C) (molar ratio): 0.24

[Prescription Example 2]
(A) potassium pyrophosphate 0.35
(B) Calcium chloride 0.15
(C) sodium fluoride 0.21
(D) polyvinylpyrrolidone 1
Silicic anhydride (abrasive silica) 7
Sorbit solution (70% aqueous solution) 35
Propylene glycol 3
Xanthan gum 0.6
Sodium polyacrylate 0.6
Silicic anhydride (thickening silica) 4
Xylit 1
Sodium lauryl sulfate 0.4
Titanium oxide 0.4
Coconut fatty acid amidopropyl betaine 0.2
Hydroxyethyl cellulose dimethyl diallyl ammonium chloride 0.05
Saccharin sodium 0.1
Perfume 0.7
Purified water residue
Total 100.0%
(A)/(C) (molar ratio): 0.21
(B)/(C) (molar ratio): 0.27

[Prescription Example 3]
(A) potassium pyrophosphate 0.2
(B) Calcium chloride 0.07
(C) sodium fluoride 0.11
(D) collagen compound 1
Silicic anhydride (abrasive silica) 7
Sorbit solution (70% aqueous solution) 35
Propylene glycol 3
Xanthan gum 0.6
Sodium polyacrylate 0.6
Silicic anhydride (thickening silica) 4
Xylit 1
Sodium lauryl sulfate 0.4
Titanium oxide 0.4
Coconut fatty acid amidopropyl betaine 0.2
Hydroxyethyl cellulose dimethyl diallyl ammonium chloride 0.05
Saccharin sodium 0.1
Perfume 0.7
Purified water residue
Total 100.0%
(A)/(C) (molar ratio): 0.23
(B)/(C) (molar ratio): 0.24

Claims

(A) condensed phosphoric acid or a salt thereof;
(B) a calcium salt;
An oral composition comprising (C) a fluorine-containing compound and (D) one or more selected from cysteine, polyvinylpyrrolidone and a collagen compound.
(A) The oral composition according to claim 1, wherein the condensed phosphoric acid or its salt is one or more selected from pyrophosphate, tripolyphosphate and metaphosphate.
(A) The oral composition according to claim 2, wherein the condensed phosphoric acid or its salt is potassium pyrophosphate.
(B) The oral composition according to claim 1, wherein the calcium salt is one or more selected from calcium glycerophosphate and calcium chloride.
(C) The oral composition according to claim 1, wherein the fluorine-containing compound is one or more selected from sodium fluoride, sodium monofluorophosphate and tin fluoride.
The oral cavity composition according to claim 1, wherein (A)/(C) has a molar ratio of 0.05 to 1 and (B)/(C) has a molar ratio of 0.1 to 2.
The oral composition according to claim 1, wherein the content of component (C) is 500 to 5,000 ppm as fluorine ions.
The content of component (A) is 0.1 to 1.5% by mass, the content of component (B) is 0.1 to 2% by mass, and the content of component (D) is 0.01 to 10% by mass. An oral composition according to claim 1.
The oral composition according to any one of claims 1 to 8, which is a dentifrice composition.