WO2023103772A1

WO2023103772A1 - Solid tumor tracing device

Info

Publication number: WO2023103772A1
Application number: PCT/CN2022/133695
Authority: WO
Inventors: 周星
Original assignee: 周星
Priority date: 2021-12-10
Filing date: 2022-11-23
Publication date: 2023-06-15
Also published as: CN116250942A

Abstract

A solid tumor tracing device (910), including an anti-displacement mechanism (910-1), a delivery mechanism (910-2), a development mechanism (4) and a medical optical tracing system (500), wherein the medical optical tracing system (500) performs optical tracing on the anti-displacement mechanism (910-1). The medical optical tracing system (500) includes a light source (1) and an optical tracing carrier (2). After light emitted by the light source (1) is conducted by means of the optical tracing carrier (2), optical tracing is performed on the optical tracing carrier (2). The light source (1) may also be a miniature LED light source (11), and a light-emitting end (11-1) of the LED light source (11) and the optical tracing carrier (2) are directly arranged as a whole, and are then placed into a human body for optical tracing. The medical optical tracing system (500) is designed; therefore, after entering a human body, the solid tumor tracing device (910) can trace a solid tumor by means of visible light; during surgery, the light source (1) is switched on, and the optical tracing carrier (2) traces the anti-displacement mechanism (910-1), such that the position of the solid tumor can be visually observed by the naked eye under the guidance of light; therefore, clinical surgery is safer and more convenient.

Description

Solid Tumor Tracer

technical field

The invention relates to a medical tracing system, in particular to a solid tumor tracing device.

Background technique

With the sharp increase in the resolution of medical imaging equipment, some tumor tissues can be found in very small volumes, such as lung nodules, uterine fibroids, esophageal tumors, and liver tumors. Due to the small size of these tumor tissues, such as pulmonary nodules, it is difficult to accurately identify them during laparoscopic resection. Therefore, it is necessary to mark the tumor tissues that need to be removed to facilitate surgical resection under laparoscope.

The current calibration of small-volume tumor tissue is usually carried out by placing marking mechanisms such as positioning hooks in the X-ray environment, and then leaving the positioning hooks and other marking mechanisms at the tumor tissue. During the operation, the position of the marking mechanism is identified. Operation.

Because the marking mechanism is usually small in size and is easy to develop in X-ray and other environments, it is often difficult to identify the marking mechanism under the endoscope and during the operation due to the interference of blood, etc., resulting in It is difficult to accurately determine the location of the tumor.

The invention discloses a tumor tissue based on visible light technology, especially a calibration technology and device for solid tumors.

Contents of the invention

The purpose of the present invention is to solve the problem that the location of small-volume tumor tissue or solid tumor tissue cannot be accurately identified in the existing clinical operation. By adopting the setting of optical tracing method, in clinical operation, through the setting of light sources of different colors, it can accurately identify the location of the clinical tumor tissue or solid tumor tissue. The tumor tissue that needs to be removed during the operation is convenient for surgical resection of the tumor tissue under the laparoscope.

The solid tumor tracking device of the present invention is characterized in that: the solid tumor tracking device 910 includes a medical optical tracking system 500; Solid tumors were identified by location.

The medical optical tracer system 500 can emit visible light under the action of the optical tracer carrier 2. In clinical operations, solid tumors can be quickly and effectively identified and resected by the prompt of visible light. .

The solid tumor tracking device 910 includes a developing mechanism 4 . The development mechanism 4 can provide development prompts in X-ray, magnetic navigation, or B-ultrasound scenarios, which facilitates the placement of the solid tumor tracking device 910 .

The solid tumor tracking device 910 includes an anti-displacement mechanism 910-1. The anti-displacement mechanism 910-1 can be fixed on the solid tumor that needs to be calibrated, so as to prevent the solid tumor tracking device 910 from moving with the movement of the human body, such as lung breathing movement, intestinal peristalsis, gastric peristalsis, etc. shift.

The solid tumor tracking device 910 includes a delivery mechanism 910-2. The delivery mechanism 910-2 can deliver the anti-displacement mechanism 910-1 to a solid tumor that needs to be marked.

In clinical applications, the delivery mechanism 910-2 delivers the anti-displacement mechanism 910-1 to the position of the solid tumor under X-ray or MRI conditions, and fixes it on the solid tumor. The carrier 2 is arranged on the anti-displacement mechanism 910-1. By positioning the anti-displacement mechanism 910-1, the position of the solid tumor can be visually observed with the naked eye under the guidance of the light during the operation.

The anti-displacement mechanism 910-1 has a hook-shaped structure, and/or a trumpet-shaped structure, and/or a dumbbell-shaped structure, and/or a coil spring-shaped structure, and/or a nail-shaped structure in a working state. The applicant here only exemplifies the manners of the anti-displacement mechanism 910-1 with the above-mentioned several structures. In practical applications, those skilled in the art can design the anti-displacement mechanism 910-1 with different structures as required 1. The applicant does not give examples one by one here, but they all do not depart from the protection scope of the present application.

The anti-displacement mechanism 910-1 has a hook-like structure and includes at least one positioning hook 910-11.

The anti-displacement mechanism 910-1 includes two positioning hooks 910-11. Usually, the anti-displacement mechanism 910-1 includes 2 or 3 positioning hooks 910-11 to better prevent the anti-displacement mechanism 910-1 from moving with the human body, such as the breathing of the lungs. Displacement occurs due to movement, intestinal peristalsis, etc.

The anti-displacement mechanism 910-1 is made of shape memory alloy, and has a linear structure outside the body, and returns to the set hook structure, and/or horn-shaped structure, and/or dumbbell after entering the human body under the action of body temperature Type structure, and/or helical spring type structure, and/or nail-like structure.

The anti-displacement mechanism 910-1 is made of developing material, which constitutes the developing mechanism 4, and develops under X-ray and/or MRI and/or B-ultrasound. In clinical use, under X-ray, and/or MRI, and/or B-ultrasound, the anti-displacement mechanism 910-1 is placed in the tumor tissue that needs to be marked.

The delivery mechanism 910-2 includes a push mechanism 910-21 and a delivery sheath 910-22.

The anti-displacement mechanism 910-1 is set in the delivery sheath 910-22, and the pushing mechanism 910-21 can push the anti-displacement mechanism 910-1 out of the delivery sheath 910-22. Launched into solid tumors.

The pushing mechanism 910-22 can be fixedly connected with the anti-displacement mechanism 910-1, and stay in the body together after the anti-displacement mechanism 910-1 is pushed out from the delivery sheath 910-21; The mechanism 910-22 can also be detachably connected with the anti-displacement mechanism 910-1, after the anti-displacement mechanism 910-1 is pushed out from the delivery sheath 910-21, and the anti-displacement mechanism 910 - 1 Disconnect, and only place the anti-displacement mechanism 910-1 on the solid tumor.

The medical optical tracer system 500 includes a light source 1 and an optical tracer carrier 2;

A. The optical trace carrier 2 contains a light-guiding material;

B. The light emitted by the light source 1 is transmitted through the optical trace carrier 2, and the optical trace carrier 2 is optically traced.

The optical tracking carrier 2 can perform optical tracking on the displacement mechanism 910-1.

The light source 1 is an LED light source 11, and/or a medical cold light source 12, and/or natural light. The light source 1 can be various light sources capable of emitting light, and the light emitted by the light source 1 can be traced after being transmitted through the optical trace carrier 1 . Compared with ordinary lighting sources, the LED light source 11 has the characteristics of small size, high luminous efficiency, and strong light source directivity. Especially in terms of safety, LED light sources have incomparable advantages over ordinary light sources. First of all, the LED light source is a low-voltage DC power supply, and the power supply voltage only needs to be 6 to 24V; secondly, no mercury is added to the LED light source, which will not cause poisoning or other harm to the human body; more importantly, the LED light source is a cold light source, which will not cause harm to the human body during work. Severe heat, safe to touch, will not cause unexpected high temperature burns to the human body. The medical cold light source 12 is a commonly used light source in the existing operation process, and the light source 1 can be placed behind, which is easy to obtain in the operating room and does not require additional equipment.

The color of light emitted by the light source 1 can be set according to background color or penetration requirements. Through the setting of the light, in the clinical operation, the doctor can directly see the position of the optical tracer 2 through the tissue with the naked eye, and then accurately identify the blood vessels, tissues or organs that need to be protected during the clinical operation, effectively avoiding Accidental injury during surgery. The light emitted by the light source 1 can be differentiated according to the background color in the body cavity or the tissue to be penetrated. When the tissue needs to be penetrated, red and yellow are the best, followed by purple and white.

The light source 1 is a flashing type of light emitting. The light source 1 can also be set in the form of intermittent lighting, flashing, etc. as required.

The intensity of light emitted by the light source 1 can be set. The intensity of the light emitted by the light source 1 can also be adjusted as required to adapt to different clinical environments. The illuminance of the light emitted by the light source 1 can reach 300,000 lux, preferably ranging from 5,000 lux to 150,000 lux.

The light source 1 includes a control system 13, the control system 13 includes a wavelength adjustment mechanism 13-1 and a light intensity adjustment mechanism 13-2, and the wavelength adjustment mechanism 13-1 can adjust the color of the emitted light by adjusting the wavelength , the light intensity adjusting mechanism 13-2 can adjust the illuminance of the emitted light.

The LED light source 11 is arranged inside the body and/or outside the body. Since the volume of the light-emitting end 11-1 of the LED light source 11 can be very small, the LED light source 11 can not only be installed outside the body, and transmit light to the human body through the optical tracer carrier 2, but also can be directly installed In the human body, the optical tracking carrier 2 is coated on the outside and placed directly on the part that needs to be tracked.

The optical tracer 2 is a light-storage self-luminous tracer 21 . Self-luminous materials refer to materials that can absorb energy in a certain way and convert it into non-equilibrium light radiation. The process of converting the energy absorbed inside the material into non-equilibrium light radiation is the luminescence process. In particular, light-storing self-luminescent materials can continue to emit light for more than 12 hours in a dark environment after a few minutes or tens of minutes under the action of external light, which can meet the tracing needs of most operations. The light-storing self-illuminating tracer carrier 21 can directly absorb the energy of the light in the operating room, so that various external lights can form the light source 1, and there is no need to directly connect the light source 1, and the use process is very simple.

The light-storage self-luminous tracer carrier 21 includes a light-storage self-illuminator 21-1 and a protection carrier 21-2.

The protective carrier 21-2 is made of a transparent light-guiding material, and the light-storing self-luminous body 21-1 is closed and arranged in the protective carrier 21-2.

The light-storing self-luminous body 21-1 can absorb external energy and convert it into light. The protective carrier 21-2 is made of transparent medical materials, which can be directly in contact with tissues. The light energy converted from the light-storing self-illuminating body 21-1 effectively passes through for effective tracing, and at the same time ensures clinical Biosafety used. The light-storing self-illuminating body 21-1 can be arranged in different positions and designed in different shapes, and can perform fixed-point tracking or overall tracking as required.

The optical trace carrier 2 is a light guiding fiber 22 . The light-guiding optical fiber 22 has a good light-guiding effect, and guides the light to different positions as required, and can be switched on or off as required, which is very convenient for clinical use.

The light guiding fiber 22 has a non-smooth surface 22-1.

The non-smooth surface 22-1 is a non-smooth surface 22-11 capable of forming reflection and/or scattering. The non-smooth surface 22-1 can realize the overall light emission of the non-smooth surface 22-1 through the reflection and/or scattering of light, so as to achieve the effect of overall tracking.

The light-guiding optical fiber 22 is intermittently provided with a light outlet 22-2. Each of the light outlets 22-2 provided intermittently has a light transmission surface 22-21 and a reflection surface 22-22, the light is transmitted through the transmission surface 22-21, and when it reaches the reflection surface 22-22, The light is reflected and emitted from the light outlet 22-2 to form a tracer point, and a plurality of the light outlets 22-2 can form a chain tracer strip.

The light-guiding optical fiber 22 is braided into a net shape, and light outlets 22-2 are scattered in different positions. The light-guiding optical fiber 22 is braided into a net shape, and the length of each of the light-guiding optical fibers 22 can be set to be different, and the light outlets 22-2 of the light-guiding optical fiber 22 are also different thereupon, scattered and distributed, which can be To realize the overall tracking in the three-dimensional space, since the light outlet 22-1 does not need to be arranged in the middle of each light-guiding optical fiber 22, the light transmission effect is better, and the visual effect of a single tracking point is very bright. It is also possible to weave the light-guiding optical fiber 22 that is provided with the light outlet 22-2 on the side and can be illuminated as a whole into a net shape, so as to realize full-area tracking of the entire anti-displacement mechanism 910-1.

The surface of the light guiding fiber 22 contains a coating 3 . The coating 3 can be designed with different properties as required, such as anticoagulation coating, hydrophilic coating or hydrophobic coating.

The optical trace carrier 2 is provided with a developing mechanism 4, and the developing mechanism 4 performs developing under X-ray, and/or MRI, and/or B-ultrasound. The developing mechanism 4 may be a developing line, and/or a developing ring, and/or a developing block and the like. The applicant here only exemplifies the above-mentioned several developing methods. In practical applications, those skilled in the art can design different developing methods according to needs. The applicant does not give examples here, but they do not deviate from the scope of the application protected range. The development mechanism 4 can perform development prompts in X-ray, magnetic navigation, or B-ultrasound scenarios, and the development mechanism 4 facilitates the optical tracking carrier 2 to be placed into the tumor tissue under the condition of visualization or navigation Inside.

The optical trace carrier 2 is made of flexible medical material, and is arranged on the outer surface of the anti-displacement mechanism 910-1.

The optical tracer carrier 2 is a light guide fiber 22, the proximal end of the light guide fiber 22 is connected to the light guide joint 26, and the far end of the light guide fiber 22 is connected and fixed on the anti-displacement mechanism 910- 1, the light outlet 22-2 of the light guide fiber 22 is set on the anti-displacement mechanism 910-1, and traces the anti-displacement mechanism 910-1.

The light guiding fiber 22 has a non-smooth surface 22-1, and the side of the light guiding fiber 22 is provided with a light outlet 22-2, and the light guiding fiber 22 is an overall display of the anti-displacement mechanism 910-1. trace.

The light guiding fiber 22 is made of flexible medical materials, and is connected and fixed on the anti-displacement mechanism 910-1. When the anti-displacement mechanism 910-1 is deformed, the light guiding fiber 22 follows the The anti-displacement mechanism 910-1 is deformed. Since the light guiding fiber 22 can be lighted as a whole, winding the light guiding fiber 22 on the anti-displacement mechanism 910-1, especially on the positioning hook 910-11, can follow the The anti-displacement mechanism 910-1 is deformed together, especially when the anti-displacement mechanism 910-1 is made of shape memory alloy, as the shape of the anti-displacement mechanism 910-1 changes, the guide The shape of the optical fiber 22 also changes accordingly to ensure the tracking effect of the anti-displacement mechanism 910-1.

The light source 1 of the medical optical tracer system 500 is an LED light source 11, the optical tracer carrier 2 is made of a transparent material, and the light-emitting end 11-1 of the LED light source 11 is set on the optical tracer carrier 2 , set on or on the anti-displacement mechanism 910-1 together with the optical trace carrier 2, and trace the anti-displacement mechanism 910-1.

When the light source 1 adopts the LED light source 11, the light-emitting end 11-1 of the LED light source 11 can be packaged with the optical trace carrier 2 as a whole, and they are jointly arranged on the anti-displacement mechanism 910-1. For the location that needs to be traced, the light emitted by the light-emitting end 11-1 is displayed after being transmitted through the light-guiding material of the optical tracer carrier 2, for clinically identifying the location of the solid tumor.

The LED light source 11 includes a light-emitting terminal 11-1, a circuit system 11-2, a drive board 11-3, and a power supply 11-4; the light-emitting terminal 11-1 passes through the circuit system 11-2 and the drive board 11 -3 and the power supply 11-4 are connected, and under the control of the driving board 11-3, the power supply 11-4 supplies power to the light emitting terminal 11-1 through the circuit system 11-2, and the light emitting The end 11-1 emits light; the driving board 11-3 and the power supply 11-4 are arranged outside the body, and the light emitting end 11-1 is arranged inside the body to trace the anti-displacement mechanism 910-1.

The circuit system 11-2 is a flexible circuit board 11-21, and the light emitting ends 11-1 of the LED light source 11 are dispersedly arranged on the flexible circuit board 11-21 and packaged in the optical tracer carrier 2, It constitutes an LED light strip, or an LED light net, or an LED light ball, and is arranged on the anti-displacement mechanism 910-1 to track the anti-displacement mechanism 910-1.

The LED light source 11 can be packaged with a single light-emitting terminal 11-1 for fixed-point tracking. It is also possible to use a flexible circuit board 11-21 for the circuit system 11-2, and the light-emitting ends 11-1 are dispersedly arranged at any position of the flexible circuit board 11-21, thereby forming a light-emitting strip, and the light-emitting strip Winding on the anti-displacement mechanism 910-1, or packaging multiple LED light sources 11 together with the optical tracer carrier 2 into a net shape, spherical shape, etc., the anti-displacement mechanism 910-1 Carry out overall tracing.

The light-emitting end 11-1 of the LED light source 11 is arranged on the anti-displacement mechanism 910-1, and the outside is coated with the optical tracer carrier 2 made of transparent material, and the light emitted by the light-emitting end 11-1 The anti-displacement mechanism 910-1 is traced.

The light-emitting ends 11-1 are dispersedly arranged on the anti-displacement mechanism 910-1, and trace the entire anti-displacement mechanism (910-1).

The light-emitting end 11-1 can be directly arranged on the anti-displacement mechanism 910-1, and then the optical tracer carrier 2 made of transparent material is coated on the outside, so that the light-emitting end 11-1 can be completely It fits the outer contour of the anti-displacement mechanism 910-1 accurately, and traces any shape of the anti-displacement mechanism 910-1.

In addition, the light-emitting end 11-1 is arranged symmetrically, and the outside covers the optical tracer carrier 2, and the internal support of the light-emitting end 11-1 and the circuit system 11-2 and the light-emitting end 11-1 Its own volume can constitute the anti-displacement mechanism 910-1, and the medical optical tracking system 500 can simultaneously have the tracking function and the positioning function of the anti-displacement mechanism 910-1.

The circuit system 11-2 is a flexible circuit board 11-21, the optical trace carrier 2 is made of soft transparent material, the light-emitting terminal 11-1, the flexible circuit board 11-21 and the developing mechanism 4 They are arranged together in the optical trace carrier 2 and on the anti-displacement mechanism 910-1. When the anti-displacement mechanism 910-1 is deformed, the light-emitting end 11-1, the The flexible circuit board 11 - 21 , the developing mechanism 4 and the optical trace carrier 2 are deformed together with the anti-displacement mechanism 910 - 1 . Especially when the anti-displacement mechanism 910-1 is made of shape memory alloy, as the shape of the anti-displacement mechanism 910-1 changes, the shape of the flexible circuit board 11-21 also changes accordingly. , to ensure the tracking effect on the anti-displacement mechanism 910-1.

In clinical use, the anti-displacement mechanism 910-1 is set in the delivery sheath 910-21, and under X-ray or MRI conditions, the delivery sheath 910-21 is inserted into the position of the solid tumor, and then the delivery sheath 910-21 is used to The pushing mechanism 910-22 pushes out the anti-displacement mechanism 910-1 and fixes it on the solid tumor, and then removes the delivery sheath 910-21 to stop and fix the anti-displacement mechanism 910-1 on the solid tumor In the operation, the light source 1 is turned on, and the optical tracer traces the anti-displacement mechanism 910-1, so that the position of the solid tumor can be visually observed with the naked eye under the guidance of the light. .

The solid tumor tracking device of the present invention includes an anti-displacement mechanism 910-1, a delivery mechanism 910-2, a developing mechanism 4, and a medical optical tracing system 500; the medical optical tracing system 500 controls the displacement preventing mechanism 910 -1 for optical tracing. The medical optical tracer system 500 includes a light source 1 and an optical tracer carrier 2 . After the light emitted by the light source 1 is transmitted through the optical trace carrier 2, the optical trace carrier 2 is optically traced. The light source 1 can also use the miniature LED light source 11, and the light-emitting end 11-1 of the LED light source 11 is directly arranged with the optical tracer carrier 2 as a whole and put into the human body for optical tracer. Due to the design of the medical optical tracer system 500, the solid tumor tracer device of the present invention can trace solid tumors through visible light after entering the human body. During surgery, the light source 1 is turned on, and the optical tracer The carrier 2 traces the anti-displacement mechanism 910-1, so that the position of the solid tumor can be visually observed with the naked eye under the guidance of the light, and the clinical operation is safer and more convenient.

Description of drawings

FIG. 1 is a three-dimensional structural schematic diagram of a solid tumor tracking device of the present invention with a positioning hook housed in a delivery sheath.

Fig. 1-1 is a sectional view of A-A in Fig. 1 .

Figure 1-2 is an enlarged view of A1 in Figure 1.

Fig. 2 is a schematic diagram of the structure when the positioning hook of Fig. 1 is pushed out.

Fig. 2-1 is a B-B sectional view of Fig. 2 .

Figure 2-2 is an enlarged view of B1 in Figure 2.

Figure 2-3 is an enlarged view of B2 in Figure 2-2.

Figures 2-4 are exploded views of Figure 2.

Fig. 3 is a schematic diagram of the structure in which the light-emitting end of the LED light source is arranged on the positioning hook.

Figure 3-1 is an enlarged view of C1 in Figure 3.

Fig. 4 is a schematic structural view of the solid tumor tracking device of the present invention with an interrupted open sleeve.

Figure 4-1 is an enlarged view of D1 in Figure 4.

Fig. 5 is a schematic structural diagram of a tracking device containing multiple solid tumors.

Figure 5-1 is an exploded view of Figure 5.

Fig. 6 is a schematic structural view of the solid tumor tracking device of the present invention with a spherical anti-displacement mechanism.

Fig. 6-1 is a sectional view along line E-E of Fig. 6 .

Figure 6-2 is an enlarged view of E1 in Figure 6-1.

Fig. 7 is a schematic structural view of the solid tumor tracking device of the present invention with a dumbbell-shaped anti-displacement mechanism.

Figure 7-1 is an enlarged view of F1 in Figure 7.

Fig. 7-2 is a sectional view of F-F in Fig. 7 .

Figure 7-3 is an enlarged view of F2 in Figure 7-2.

Figure 7-4 is a coated dumbbell-shaped anti-displacement mechanism.

Fig. 8 is a schematic structural view of the solid tumor tracking device of the present invention with a helical anti-displacement mechanism.

Figure 8-1 is an enlarged view of G1 in Figure 8.

Fig. 9 is a schematic structural view of the solid tumor tracking device of the present invention which includes both a helical constant and a dumbbell-shaped anti-displacement mechanism.

Figure 9-1 is an enlarged view of H1 in Figure 9.

Fig. 10 is a schematic structural view of a solid tumor tracking device of the present invention including an LED light source.

Fig. 10-1 is a schematic structural view of the delivery mechanism in Fig. 10 after being removed.

Fig. 11 is a schematic structural diagram of a solid tumor tracking device of the present invention including a medical cold light source.

Fig. 12 is a schematic structural diagram of a solid tumor tracking device of the present invention containing a light-storing self-luminescent tracking carrier.

Figure 12-1 is an enlarged view of I1 in Figure 12.

Fig. 13 is a schematic diagram of the working principle of the solid tumor tracking device of the present invention when it is inserted into a pulmonary nodule.

Fig. 13-1 is a working principle diagram of Fig. 13 after the delivery mechanism is removed and the light-guiding fiber is connected to the light source.

In the above figure:

500 is a medical optical tracing system, and 910 is a solid tumor tracing device of the present invention.

1 is a light source, 2 is an optical tracer carrier, 3 is a coating, 4 is a developing mechanism, and 5 is a protective sleeve.

11 is the LED light source, 12 is the medical cold light source, 13 is the control system, 11-1 is the light-emitting terminal, 11-2 is the circuit system, 11-3 is the drive board, 11-4 is the power supply, 13-1 is the wavelength adjustment mechanism , 13-2 is a light intensity adjustment mechanism, and 11-21 is a flexible circuit board.

21 is a light-storage self-illumination tracer carrier, 22 is a light-guiding optical fiber, and 26 is a light-guiding joint; 21-1 is a light-storage self-illumination body, and 21-2 is a protection carrier; 22-1 is a non-smooth surface, and 22-2 is a Light outlet: 22-11 is a non-smooth surface capable of forming reflection and/or scattering, 22-21 is a conductive surface, and 22-22 is a reflective surface.

910-1 is an anti-displacement mechanism, 910-2 is a delivery mechanism; 910-11 is a positioning hook, 910-21 is a delivery sheath, and 910-22 is a pushing mechanism.

Detailed ways

Embodiment 1: The solid tumor tracking device of the present invention

Referring to Fig. 1 to Fig. 5-1, the anti-displacement mechanism 910-1, the delivery mechanism 910-2, the developing mechanism 4 and the medical optical tracer system 500 in this embodiment, the medical optical tracer system 500 is for the described The anti-displacement mechanism 910-1 performs optical tracking.

The anti-displacement mechanism 910-1 can be fixed on the solid tumor that needs to be calibrated, so as to prevent the solid tumor tracking device 910 from moving with the movement of the human body, such as lung breathing movement, intestinal peristalsis, gastric peristalsis, etc. shift.

The color of light emitted by the light source 1 can be set according to background color or penetration requirements. Through the setting of light, in clinical operations, doctors can directly see the position of the optical tracer carrier 2 through the tissue with the naked eye, and then accurately identify the blood vessels, tissues or organs that need to be protected during clinical operations, effectively avoiding Accidental injury during surgery. The light emitted by the light source 1 can be differentiated according to the background color in the body cavity or the tissue to be penetrated. When the tissue needs to be penetrated, red and yellow are the best, followed by purple and white.

The light source 1 is a flashing type of light emitting. The light source 1 can also be set to intermittent lighting, flashing, etc. as required.

10 and 11, the light source 1 includes a control system 13, the control system 13 includes a wavelength adjustment mechanism 13-1 and a light intensity adjustment mechanism 13-2, and the wavelength adjustment mechanism 13-1 can adjust the wavelength To adjust the color of the emitted light, the light intensity adjustment mechanism 13-2 can adjust the illuminance of the emitted light.

Referring to Fig. 1 to Fig. 5-1, in this embodiment, the anti-displacement mechanism 910-1 is in a hook-shaped structure in working state, and includes two positioning hooks 910-11.

Usually, the anti-displacement mechanism 910-1 includes 2 or 3 positioning hooks 910-11 to better prevent the anti-displacement mechanism 910-1 from moving with the human body, such as the breathing of the lungs. Displacement occurs due to movement, intestinal peristalsis, etc.

In practical applications, the anti-displacement mechanism 910-1 can also be a spherical structure (refer to FIG. 6 to FIG. 6-2 ), a horn-shaped structure, and/or a dumbbell-shaped structure (refer to FIG. 7 to FIG. 3, Figure 9 and Figure 9-1), and/or a helical spring structure (refer to Figure 8 and Figure 8-1, Figure 9 and Figure 9-1), and/or a nail-like structure. The applicant here only exemplifies the manners of the anti-displacement mechanism 910-1 with the above-mentioned several structures. In practical applications, those skilled in the art can design the anti-displacement mechanism 910-1 with different structures as required 1. The applicant does not give examples one by one here, but they all do not depart from the protection scope of the present application.

The anti-displacement mechanism 910-1 can be made of shape memory alloy, which has a linear structure outside the body, and returns to the set hook-shaped structure and/or trumpet-shaped structure under the action of body temperature after entering the human body, and/or A dumbbell-shaped structure, and/or a helical spring-shaped structure, and/or a spike-shaped structure.

In this embodiment, the anti-displacement mechanism 910-1 is made of a developing material, which constitutes the developing mechanism 4, and develops under X-ray and/or MRI and/or B-ultrasound. In clinical use, under X-ray, and/or MRI, and/or B-ultrasound, the anti-displacement mechanism 910-1 is placed in the tumor tissue that needs to be marked.

Referring to Fig. 1 and Fig. 1-1, the anti-displacement mechanism 910-1 is set in the delivery sheath 910-22, and the pushing mechanism 910-21 can push the anti-displacement mechanism 910-1 from The delivery sheath 910-22 is pushed out and placed into a solid tumor.

The medical optical tracer system 500 includes a light source 1 and an optical tracer carrier 2 .

The optical tracer carrier 2 contains a light-guiding material, and the light emitted by the light source 1 is conducted through the optical tracer carrier 2 and optically traces the optical tracer carrier 2 .

10 to 11, the light source 1 may be an LED light source 11, and/or a medical cold light source 12, and/or natural light. The light source 1 can be various light sources capable of emitting light, and the light emitted by the light source 1 can be traced after being transmitted through the optical trace carrier 1 . Compared with ordinary lighting sources, the LED light source 11 has the characteristics of small size, high luminous efficiency, and strong light source directivity. Especially in terms of safety, LED light sources have incomparable advantages over ordinary light sources. First of all, the LED light source is a low-voltage DC power supply, and the power supply voltage only needs to be 6 to 24V; secondly, no mercury is added to the LED light source, which will not cause poisoning or other harm to the human body; more importantly, the LED light source is a cold light source, which will not cause harm to the human body during work. Severe heat, safe to touch, will not cause unexpected high temperature burns to the human body. The medical cold light source 12 is a commonly used light source in the existing operation process, and the light source 1 can be placed behind, which is easy to obtain in the operating room and does not require additional equipment.

In this embodiment, the light source 1 is the LED light source 11 .

The LED light source 11 can be arranged inside the body, or outside the body. Since the volume of the light-emitting end 11-1 of the LED light source 11 can be very small, usually the size of the light-emitting end 11-1 is controlled below 2 mm, such as an LED lamp with a package size between 0.2 mm and 0.5 mm. Therefore, the The above-mentioned LED light source 11 can not only be installed outside the body, and conduct light transmission into the human body through the optical tracer carrier 2, but also can be directly installed in the human body, coated with the optical tracer carrier 2, and directly arranged in the place where tracer is required. parts.

When the LED light source 11 is placed outside the body, the optical trace carrier 2 is a light guiding fiber 22 . The light-guiding optical fiber 22 has a good light-guiding effect, and guides the light to different positions as required, and can be switched on or off as required, which is very convenient for clinical use.

Referring to FIG. 2 and FIG. 4 , in this embodiment, the light guiding fiber 22 has a non-smooth surface 22 - 1 .

The non-smooth surface 22-1 is a non-smooth surface 22-11 capable of forming reflection and/or scattering. The overall luminescence of the non-smooth surface 22-1 can be realized to achieve the effect of overall tracking.

The light-guiding optical fiber 22 is intermittently provided with a light outlet 22-2. Each of the light outlets 22-2 provided intermittently has a light transmission surface 22-21 and a reflection surface 22-22, the light is transmitted through the transmission surface 22-21, and when it reaches the reflection surface 22-22, The light is reflected and emitted from the light outlet 22-2 to form a tracer point, and a plurality of the light outlets 22-2 can form a chain tracer strip. The light guiding fiber 22 can be fixed on the anti-displacement mechanism 910-1 through the protective sleeve 5, refer to the figure.

The light-guiding optical fiber 22 can also be woven into a net shape, and the light outlets 22-2 are scattered in different positions. The light-guiding optical fiber 22 is braided into a net shape, and the length of each of the light-guiding optical fibers 22 can be set to be different, and the light outlets 22-2 of the light-guiding optical fiber 22 are also different thereupon, scattered and distributed, which can be To realize the overall tracking in the three-dimensional space, since the light outlet 22-1 does not need to be arranged in the middle of each light-guiding optical fiber 22, the light transmission effect is better, and the visual effect of a single tracking point is very bright. It is also possible to weave the light-guiding optical fiber 22 that is provided with the light outlet 22-2 on the side and can be illuminated as a whole into a net shape, so as to realize full-area tracking of the entire anti-displacement mechanism 910-1.

Referring to FIG. 7-4 , the surface of the light guiding fiber 22 may be provided with a coating 3 . The coating 3 can be designed with different properties as required, such as anticoagulation coating, hydrophilic coating or hydrophobic coating.

When the anti-displacement mechanism 910-1 is made of non-developing material, the developing mechanism 4 can also be arranged on the optical tracer carrier 2, and the developing mechanism 4 can be used under X-ray and/or MRI , and/or develop under B-ultrasound. The developing mechanism 4 may be a developing line 41, and/or a developing ring 42, and/or a developing block 43, and the like. The applicant here only exemplifies the above-mentioned several developing methods. In practical applications, those skilled in the art can design different developing methods according to needs. The applicant does not give examples here, but they do not deviate from the scope of the application protected range. The development mechanism 4 can perform development prompts in X-ray, magnetic navigation, or B-ultrasound scenarios, and the development mechanism 4 facilitates the optical tracking carrier 2 to be placed into the tumor tissue under the condition of visualization or navigation Inside, refer to Fig.**.

In this embodiment, the proximal end of the light guiding fiber 22 is connected to the light guiding connector 26, the far end of the light guiding fiber 22 is connected and fixed on the anti-displacement mechanism 910-1, the light guiding fiber The light outlet 22-2 of 22 is set on the anti-displacement mechanism 910-1.

Referring to Fig. 2 to Fig. 2-3, the light guide fiber 22 is made of flexible medical material, connected and fixed on the anti-displacement mechanism 910-1, when the anti-displacement mechanism 910-1 is deformed , the light guiding fiber 22 is deformed along with the anti-displacement mechanism 910-1. Since the light guiding fiber 22 can be lighted as a whole, winding the light guiding fiber 22 on the anti-displacement mechanism 910-1, especially on the positioning hook 910-11, can follow the The anti-displacement mechanism 910-1 is deformed together, especially when the anti-displacement mechanism 910-1 is made of shape memory alloy, as the shape of the anti-displacement mechanism 910-1 changes, the guide The shape of the optical fiber 22 also changes accordingly to ensure the tracking effect of the anti-displacement mechanism 910-1.

When the LED light source 11 adopts a miniature design, the LED light source 11 includes a light-emitting terminal 11-1 and a circuit system 11-2. The light-emitting end 11-1 can be set inside the body.

At this time, the optical trace carrier 2 is made of a transparent material, and the light-emitting end 11-1 of the LED light source 11 can be packaged on the optical trace carrier 2, and is set together with the optical trace carrier 2 On the anti-displacement mechanism 910-1, trace the anti-displacement mechanism 910-1.

The light emitted from the light-emitting end 11-1 is displayed after being transmitted through the light-guiding material of the optical tracer carrier 2, for clinically identifying the position of a solid tumor.

Referring to Fig. 3 and Fig. 3-1 and Fig. 7 to Fig. 7-3, the LED light source 11 includes a light-emitting terminal 11-1, a circuit system 11-2, a driving board 11-3 and a power supply 11-4; the light-emitting terminal 11-1 is connected to the drive board 11-3 and the power supply 11-4 through the circuit system 11-2, and under the control of the drive board 11-3, the power supply 11-4 passes through the circuit The system 11-2 supplies power to the light-emitting end 11-1, and the light-emitting end 11-1 emits light; the driving board 11-3 and the power supply 11-4 are arranged outside the body, and the light-emitting end 11-1 In vivo, the anti-displacement mechanism 910-1 is tracked.

The LED light source 11 can be packaged with a single light-emitting terminal 11-1 for fixed-point tracing, or the circuit system 11-2 can be used with a flexible circuit board 11-21, and the light-emitting terminals 11-1 can be dispersed be arranged at any position of the flexible circuit board 11-21 to form a light strip, and the light strip is wound on the anti-displacement mechanism 910-1, or a plurality of the LED light sources 11 and the optical display The tracking carrier 2 is packaged together into a shape such as a mesh or a ball, and the overall tracking of the anti-displacement mechanism 910-1 is carried out.

The light-emitting end 11-1 of the LED light source 11 can also be directly arranged on the anti-displacement mechanism 910-1, and the optical trace carrier 2 made of transparent material is coated on the outside, and the light-emitting end 11-1 The emitted light traces the anti-displacement mechanism 910-1.

In addition, the light-emitting end 11-1 is arranged symmetrically, and the outside covers the optical tracer carrier 2, and the internal support of the light-emitting end 11-1 and the circuit system 11-2 and the light-emitting end 11-1 Its own volume can constitute the anti-displacement mechanism 910-1, and the medical optical tracer system 500 can have both the tracing function and the positioning function of the anti-displacement mechanism 910-1, refer to Fig. 7 to Fig. 7-4.

Referring to FIG. 12 and FIG. 12-1 , the optical trace carrier 2 is a light-storing self-luminous trace carrier 21 . Self-luminous materials refer to materials that can absorb energy in a certain way and convert it into non-equilibrium light radiation. The process of converting the energy absorbed inside the material into non-equilibrium light radiation is the luminescence process. In particular, light-storing self-luminescent materials can continue to emit light for more than 12 hours in a dark environment after a few minutes or tens of minutes under the action of external light, which can meet the tracing needs of most operations. The light-storing self-illuminating tracer carrier 21 can directly absorb the energy of the light in the operating room, so that various external lights can form the light source 1, and there is no need to directly connect the light source 1, and the use process is very simple.

Referring to FIG. 13 , in clinical application, when lung tumors (especially lung nodules) or liver tumors need to be calibrated, the anti-displacement mechanism 910-1 is set in the delivery sheath 910-21, and Under the X-ray state, the delivery sheath 910-21 is inserted into the position of the solid tumor, and then the anti-displacement mechanism 910-1 is pushed out by the pushing mechanism 910-22, and fixed on the lung tumor (especially the lung nodule). ), or liver tumors and other solid tumors, and then remove the delivery sheath 910-21, stay and fix the anti-displacement mechanism 910-1 on the solid tumor, and then connect the light-guiding optical fiber 22 to the On the light source 1, refer to Figure 13-1. During the operation, the light source 1 is turned on, and the optical tracer carrier 2 traces the anti-displacement mechanism 910-1, so that under the guidance of light, the naked eye can see Visually observe the location of lung tumors (especially lung nodules), or solid tumors such as liver tumors.

In clinical application, if it is necessary to calibrate the uterine fibroids, under the guidance of B-ultrasound, the anti-displacement mechanism 910-1 can be delivered to the uterine fibroids and fixed on the uterine fibroids. The light source 1 and the optical tracer 2 trace the anti-displacement mechanism 910-1, so that the position of the uterine fibroids can be visually observed with the naked eye under the guidance of the light.

The solid tumor tracking device of this embodiment is designed with the medical optical tracking system 500. The solid tumor tracking device of the present invention can track solid tumors through visible light after entering the human body. The light source 1 and the optical tracer carrier trace the anti-displacement mechanism 910-1, so that the position of the solid tumor can be visually observed with the naked eye under the guidance of the light, and the clinical operation is safer and more convenient.

It should be noted that the structures disclosed and described herein can be replaced by other structures with the same effect, and the embodiments described in the present invention are not the only structures for realizing the present invention. Although preferred embodiments of the present invention have been described and described herein, it is clear to those skilled in the art that these embodiments are for illustration only, and that numerous changes, modifications and improvements can be made by those skilled in the art. Instead, without departing from the present invention, therefore, the protection scope of the present invention should be defined according to the spirit and scope of the appended claims of the present invention.

Claims

The solid tumor tracking device is characterized in that: the solid tumor tracking device (910) includes a medical optical tracking system (500); Tracking technology for location identification of solid tumors.
The solid tumor tracking device according to claim 1, characterized in that: the solid tumor tracking device (910) includes a developing mechanism (4).
The solid tumor tracking device according to claim 1, characterized in that: the solid tumor tracking device (910) includes an anti-displacement mechanism (910-1).
The solid tumor tracking device according to claim 1, characterized in that: the solid tumor tracking device (910) comprises a delivery mechanism (910-2).
The solid tumor tracking device according to claim 1, characterized in that: the anti-displacement mechanism (910-1) has a hook-shaped structure, and/or a horn-shaped structure, and/or a dumbbell-shaped structure, and /or helical spring-type structure, and/or nail-like structure.
The solid tumor tracking device according to claim 5, characterized in that: the anti-displacement mechanism (910-1) has a hook-like structure and includes at least one positioning hook (910-11).
The solid tumor tracking device according to claim 6, characterized in that: the anti-displacement mechanism (910-1) includes two positioning hooks (910-11).
The solid tumor tracking device according to claim 6, characterized in that: the anti-displacement mechanism (910-1) is made of a shape memory alloy, which has a linear structure outside the body, and returns to a shape under the action of body temperature after entering the human body. The set hook-shaped structure, and/or trumpet-shaped structure, and/or dumbbell-shaped structure, and/or coil spring-shaped structure, and/or nail-shaped structure.
The solid tumor tracking device according to claim 1, characterized in that: the anti-displacement mechanism (910-1) is made of a developing material, constituting the developing mechanism (4), under X-ray, and/or Develop under MRI and/or B-ultrasound.
The solid tumor tracking device according to claim 1, characterized in that: the delivery mechanism (910-2) comprises a push mechanism (910-21) and a delivery sheath (910-22).
The solid tumor tracking device according to claim 10, characterized in that: the anti-displacement mechanism (910-1) is set in the delivery sheath (910-22), and the pushing mechanism (910-21 ) is capable of pushing the anti-displacement mechanism (910-1) out of the delivery sheath (910-22) into a solid tumor.
The solid tumor tracing device according to claim 1, characterized in that: the medical optical tracing system (500) comprises a light source (1) and an optical tracing carrier (2);

A, the optical tracer carrier (2) contains a light-guiding material;

B. The light emitted by the light source (1) is transmitted through the optical trace carrier (2), and the optical trace carrier (2) is optically traced.
The solid tumor tracking device according to claim 12, characterized in that: the light source (1) is an LED light source (11), and/or a medical cold light source (12), and/or natural light.
The medical optical tracing system according to claim 12, characterized in that: the color of the light emitted by the light source (1) can be set according to background color or penetration requirements.
The medical optical tracing system according to claim 12, characterized in that: the light source (1) is a flashing light.
The medical optical tracing system according to claim 12, characterized in that the intensity of the light emitted by the light source (1) can be set.
The solid tumor tracking device according to claim 12, characterized in that: the LED light source (11) is set inside the body and/or outside the body.
The solid tumor tracking device according to claim 12, characterized in that: the optical tracking carrier (2) is a light-storing self-luminous tracking carrier (21).
The solid tumor tracking device according to claim 18, characterized in that: the light-storage self-luminescence tracing carrier (21) includes a light-storage self-luminescence body (21-1) and a protection carrier (21-2).
The solid tumor tracking device according to claim 19, characterized in that: the protective carrier (21-2) is made of transparent light-guiding material, and the light-storing self-illuminating body (21-1) is closed and arranged on the protective Inside the carrier (21-2).
The solid tumor tracking device according to claim 12, characterized in that: the optical tracking carrier (2) is a light-guiding optical fiber (22).
The solid tumor tracking device according to claim 21, characterized in that: the light guiding optical fiber (22) has a non-smooth surface (22-1).
The solid tumor tracking device according to claim 22, characterized in that: the non-smooth surface (22-1) is a non-smooth surface (22-11) capable of forming reflection and/or scattering
The solid tumor tracking device according to claim 23, characterized in that: the light-guiding optical fiber (22) is intermittently provided with light outlets (22-2).
The solid tumor tracking device according to claim 24, characterized in that: the light guiding optical fiber (22) is woven into a net shape, and light outlets (22-2) are scattered in different positions.
The solid tumor tracking device according to claim 12, characterized in that: the surface of the light-guiding optical fiber (22) contains a coating (3).
According to the medical optical tracer system according to claim 21, it is characterized in that: the optical tracer carrier (2) is provided with a developing mechanism (4), and the developing mechanism (4) is under X-ray and/or MRI Under, and/or under the B ultrasound for development. .
The medical optical tracer system according to claim 1, characterized in that: the optical tracer carrier (2) is made of compliant medical material, and is arranged on the outer surface of the anti-displacement mechanism (910-1).
The solid tumor tracking device according to claim 1, characterized in that: the optical tracking carrier (2) is a light-guiding optical fiber (22), and the proximal end of the light-guiding optical fiber (22) is connected to the light-guiding joint (26 ) connection, the far end of the light guiding fiber (22) is connected and fixed on the anti-displacement mechanism (910-1), and the light outlet (22-2) of the light guiding fiber (22) is set on the On the anti-displacement mechanism (910-1), trace the anti-displacement mechanism (910-1).
The solid tumor tracing device according to claim 29, characterized in that: the light guiding fiber (22) has a non-smooth surface (22-1), and the side of the light guiding fiber (22) is provided with a light outlet ( 22-2), the light guiding optical fiber (22) traces the anti-displacement mechanism (910-1) as a whole.
The solid tumor tracking device according to claim 30, characterized in that: the light-guiding optical fiber (22) is made of flexible medical material, connected and fixed on the anti-displacement mechanism (910-1), when the When the anti-displacement mechanism (910-1) deforms, the light guide fiber (22) deforms along with the anti-displacement mechanism (910-1).
The solid tumor tracking device according to claim 1, characterized in that: the light source (1) of the medical optical tracking system (500) is an LED light source (11), and the optical tracking carrier (2) is made of a transparent material The light-emitting end (11-1) of the LED light source (11) is arranged on the optical trace carrier (2), and is arranged on the anti-displacement mechanism together with the optical trace carrier (2) (910-1) or on the anti-displacement mechanism (910-1), trace the anti-displacement mechanism (910-1).
The solid tumor tracing device according to claim 32, characterized in that: the LED light source (11) includes a light-emitting terminal (11-1), a circuit system (11-2), a driving board (11-3) and a power supply ( 11-4); the light-emitting terminal (11-1) is connected to the drive board (11-3) and the power supply (11-4) through the circuit system (11-2), and the drive board Under the control of (11-3), the power supply (11-4) supplies power to the light-emitting terminal (11-1) through the circuit system (11-2), and the light-emitting terminal (11-1) emits light ; The driving board (11-3) and the power supply (11-4) are arranged outside the body, and the light-emitting terminal (11-1) is arranged inside the body to show the anti-displacement mechanism (910-1) trace.
The solid tumor tracking device according to claim 33, characterized in that: the circuit system (11-2) is a flexible circuit board (11-21), and the light emitting end (11-1) of the LED light source (11) Dispersed on the flexible circuit board (11-21) and packaged in the optical tracer carrier (2), forming an LED light strip, or LED light net, or LED light ball, arranged on the anti-displacement On the mechanism (910-1), trace the anti-displacement mechanism (910-1).
The solid tumor tracking device according to claim 29, characterized in that: the light-emitting end (11-1) of the LED light source (11) is set on the anti-displacement mechanism (910-1), and the outer coating is transparent The optical tracking carrier (2) is made of material, and the light emitted from the light-emitting end (11-1) tracks the anti-displacement mechanism (910-1).
The solid tumor tracking device according to claim 31, characterized in that: the light-emitting ends (11-1) are dispersedly arranged on the anti-displacement mechanism (910-1), and the anti-displacement mechanism ( 910-1) for overall tracing.
The solid tumor tracking device according to claim 36, characterized in that: the circuit system (11-2) is a flexible circuit board (11-21), and the optical tracking carrier (2) is made of soft transparent material In this way, the light-emitting end (11-1), the flexible circuit board (11-21) and the developing mechanism (4) are arranged together in the optical tracer carrier (2), and arranged on the anti-displacement mechanism (910-1), when the anti-displacement mechanism (910-1) deforms, the light emitting end (11-1), the flexible circuit board (11-21), the developing mechanism ( 4) deform together with the optical tracking carrier (2) along with the anti-displacement mechanism (910-1).