WO2023102772A1 - Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation - Google Patents

Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation Download PDF

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Publication number
WO2023102772A1
WO2023102772A1 PCT/CN2021/136445 CN2021136445W WO2023102772A1 WO 2023102772 A1 WO2023102772 A1 WO 2023102772A1 CN 2021136445 W CN2021136445 W CN 2021136445W WO 2023102772 A1 WO2023102772 A1 WO 2023102772A1
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WO
WIPO (PCT)
Prior art keywords
tail
small animal
small
support
auxiliary device
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PCT/CN2021/136445
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English (en)
Chinese (zh)
Inventor
汤勇
詹阳
葛登云
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中国科学院深圳先进技术研究院
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Application filed by 中国科学院深圳先进技术研究院 filed Critical 中国科学院深圳先进技术研究院
Priority to PCT/CN2021/136445 priority Critical patent/WO2023102772A1/fr
Publication of WO2023102772A1 publication Critical patent/WO2023102772A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes

Definitions

  • the invention relates to the technical field of animal nerve function research, in particular to an auxiliary device for detecting physiological indicators of small animals and a usage method thereof.
  • the light-regulated animal blood glucose real-time monitoring device buckles the animal in an opaque cylinder with a lower opening twice the volume of the animal, and opens several small holes around the top and lower end of the cylinder to facilitate light stimulation and tail detection of blood glucose.
  • the small animal faces a closed cover with little light, which cannot meet the needs of real-time observation of the whole state, and the small animal can freely rotate inside.
  • the small animal is connected with a relatively light and fragile equipment line It is easy to cause the equipment line to be entangled or broken.
  • the current devices used to fix small animals to assist in the detection of changes in animal physiological indicators have problems such as easily causing stress reactions and inconvenient observation in animals, and there are problems such as poor animal fixation, and animals can move freely and turn around.
  • the problem of entanglement or disconnection of the equipment lines connected to the body cannot ensure the accuracy of the detection of changes in physiological indicators of animals.
  • an object of the present invention is to provide an auxiliary device for the detection of small animal physiological indicators and a method of use thereof.
  • the device can open and elastically fix the small animal, so that the small animal's body is loose and semi-free, and the field of vision is wide. After a short period of adaptation, it can stay in place naturally and quietly, which can prevent the small animal from producing a stress response and avoiding the small animal spinning around, which is conducive to accurately detecting changes in the physiological indicators of the small animal.
  • An auxiliary device for detecting physiological indicators of small animals comprising a support structure, a device main body supported on the support structure, an elastic tail root fixing component, and a tail sleeve tube;
  • the device main body includes a support part movably supported on the support structure and a funnel part extending from the support part, the funnel part is used for accommodating small animals and the bottom is provided with a bottom opening, and the bottom opening It is used for the tail of small animals to fall naturally and to facilitate the collection of excrement of small animals;
  • the elastic tail root fixing component is arranged between the bottom opening and the tail sleeve tube, and is used to fix the tail root of the small animal;
  • the tail sleeve tube is used to fix the rear part of the tail of the small animal, and the temperature of the tail sleeve tube is set and maintained within a certain temperature range to ensure that the tail of the small animal can be placed comfortably and to facilitate experimental sampling operations.
  • the main body of the device is made of transparent material, and the inner and outer surfaces are smooth, so as to avoid the small animals from being blocked, and facilitate the observation and recording of the real-time status of the small animals.
  • the elastic tail root fixing assembly includes an adhesive tape, a clip, an elastic member and a tail root fixing ring, wherein the adhesive tape is used to stick the tail root protruding from the bottom opening, the The clip is used to clamp the clampable part of the adhesive tape, and the elastic member is used to bind and fix the clip to the tail root fixing ring, so as to keep the small animal within an autonomous elastic range, And the head of the small animal can face the fixed side of the funnel without turning around, so as to keep all kinds of connections on the small animal quiet and stable.
  • the tail root fixing ring has two fixing ears, and after the elastic member binds and fixes the clip, two ends thereof are respectively fixed to the corresponding fixing ears.
  • the supporting structure includes a supporting base, an L-shaped bracket connected to the supporting base, and a supporting ring connected to the L-shaped bracket, and the supporting part of the device body is a cylinder shaped structure and the top is extended to form an extension flange, the support part is movably sleeved in the support ring, and can form a state where the bottom surface of the extension flange is opposed to the top surface of the support ring, In order to be able to adjust the state of the main body of the device by lifting the supporting part, it is convenient to induce small animals to actively climb and protrude their tails from the bottom opening of the funnel part.
  • the support part has a top opening, so that the connecting wire of the external detection device can be introduced into the funnel part through the top opening and connected to the small animal.
  • the support structure further includes a first support column connecting the support base and the tail root fixing ring, and a second support column connecting the support base and the tail sleeve tube.
  • a method for using an auxiliary device for detecting physiological indicators of small animals comprising steps:
  • the step S1 includes the steps of:
  • the main body of the device is lifted obliquely so that the small animal actively climbs to induce it to protrude its tail through the bottom opening of the funnel.
  • the method for using the auxiliary device for detection of small animal physiological indicators further includes the step: S5, after the small animal adapts to the connection line connected to the detection device, perform optogenetic stimulation, electrical stimulation, etc. Any one or more of the experimental operations of stimulation, catheter administration, catheter collection of body fluids, tail blood collection, and electromyography collection.
  • the auxiliary device for the detection of small animal physiological indicators of the present invention adopts an open elastic fixation method to fix the small animal, so that the small animal can be naturally and elastically maintained in a quiet and stable state, thereby preventing the small animal from producing stress responses and freedom. Rotating, thereby avoiding entanglement or disconnection of various equipment cables connected to small animals, especially light-weight filament wires will not be bitten off by small animals or torn off due to small animals spinning and winding, which can be done To reduce the foreign body sensation on small animals and smoothly connect various precision testing equipment.
  • the device main body of the auxiliary device for small animal physiological index detection of the present invention is made of transparent materials, which can facilitate multi-angle naked eye observation or use a camera to record the real-time state of small animals in the device main body, satisfying real-time Observe the full state as needed.
  • the main body of the auxiliary device for the detection of small animal physiological indicators of the present invention is provided with the bottom opening, which not only facilitates the natural extension of the tail of the small animal, but also facilitates the real-time collection of excrement of the small animal.
  • the tail sleeve tube used in the auxiliary device for the detection of small animal physiological indicators of the present invention can be kept within a certain temperature range, such as within 25°C to 37°C, that is, kept at a relatively comfortable temperature for small animals Within the range, the tail of the small animal can be comfortably placed, and at the same time, it is convenient for experimental operations, such as blood collection from the tail of the small animal.
  • Fig. 1 is a schematic structural diagram of the auxiliary device for detecting physiological indicators of small animals according to a preferred embodiment of the present invention.
  • Fig. 2 is a flow chart of the method for using the auxiliary device for detecting physiological indicators of small animals according to the above selected embodiment of the present invention.
  • support structure 10 support structure 10; support base 11; L-shaped bracket 12; support ring 13; first support column 14; second support column 15; device main body 20; ; Funnel 22; Bottom opening 221; Elastic tail root fixing assembly 30; Adhesive tape 31; Clip 32;
  • the term “a” should be understood as “at least one” or “one or more”, that is, in one embodiment, the number of an element can be one, while in another embodiment, the number of the element
  • the quantity can be multiple, and the term “a” cannot be understood as a limitation on the quantity.
  • connection should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; it can be mechanically connected, or electrically connected, or can communicate with each other; it can be directly connected, or indirectly connected through an intermediary, and it can be the internal communication of two components or the interaction of two components relation.
  • installation connection
  • connection connection
  • connection should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; it can be mechanically connected, or electrically connected, or can communicate with each other; it can be directly connected, or indirectly connected through an intermediary, and it can be the internal communication of two components or the interaction of two components relation.
  • the present invention provides an open elastic auxiliary device for fixing small animals, so as to achieve loose and semi-free bodies of small animals, wide field of vision, and to stay in place naturally and quietly after a short period of adaptation, thereby avoiding stress reactions of small animals And free rotation, to ensure accurate detection of changes in the physiological indicators of small animals, to provide accurate experimental basis for the study of animal nerve function.
  • the auxiliary device for small animal physiological index detection includes a support structure 10, a device main body 20 supported on the support structure 10, an elastic tail root fixing assembly 30, and a tail sleeve tube 40; wherein the device main body 20 includes a Movably supported on the support part 21 of the support structure 10 and the funnel part 22 extending from the support part 21, the funnel part 22 is used to accommodate small animals and the bottom is provided with a bottom opening 221, the bottom opening 221 It is used for the tail of the small animal to fall naturally and to facilitate the collection of excrement of the small animal; wherein the elastic tail root fixing assembly 30 is arranged between the bottom opening 221 and the tail sleeve tube 40 for fixing the small animal.
  • tail sleeve 40 is used to fix the rear part of the tail of the small animal, and the temperature of the tail sleeve 40 is set and kept within a certain temperature range to ensure that the tail of the small animal can be comfortable Place and facilitate experimental sampling operations.
  • the main body 20 of the device is made of transparent material, and the inner and outer surfaces are smooth, so as to avoid the small animal being blocked, and most of the body of the small animal can be seen with the naked eye from multiple angles, thereby facilitating multi-angle naked eye observation.
  • a camera is used to record the real-time state of the small animal in the device main body 20 to meet the needs of real-time observation of the whole state.
  • the device main body 20 is made of acrylic material.
  • the tail sleeve tube 40 can be connected with an external heating device or coated with a heat preservation bag so that its temperature can be kept within a certain temperature range.
  • the specific temperature maintenance of the tail sleeve tube 40 in the present invention The method is not limited.
  • the temperature of the tail sleeve 40 is preferably kept at 25°C to 37°C, so as to be close to the body temperature of the small animal, and kept within a relatively comfortable temperature range for the small animal.
  • the tail can be comfortably placed and convenient for experimental sampling operations, such as blood collection operations on small animal tails.
  • the elastic tail root fixing assembly 30 includes an adhesive tape 31, a clip 32, an elastic member 33 and a tail root fixing ring 34, wherein the adhesive tape 31 is used to stick the tail root protruding from the bottom opening 221, so
  • the clip 32 is used to clamp the clampable part of the adhesive tape 31, and the elastic member 33 is used to bind and fix the clip 32 on the tail root fixing ring 34, so as to keep the small animal in a Within the scope of autonomy, and the head of the small animal can face the fixed side of the funnel 22 without turning around, so as to keep all kinds of connections on the small animal quiet and stable.
  • the adhesive tape 31 is preferably a medical adhesive tape, and the clampable part of the adhesive tape 31 is the part of the adhesive tape 31 other than the tail base of the small animal.
  • the elastic member 33 Preferably a rubber band.
  • the tail root fixing ring 34 has two fixing ears 341 , and the elastic member 33 binds and fixes the clip 32 and fixes both ends to the corresponding fixing ears 341 respectively.
  • the small animal can be in a loose and semi-free state, and since the main body 20 of the device is a transparent device, the small animal has a wide field of vision, After a short period of semi-free activities, the small animals can adapt and stay in place naturally and quietly, naturally and flexibly maintain a quiet and stable state, avoiding stress reactions. Simultaneously, because the tail root of the small animal is fixed on the tail root fixing ring 34 via the clip 32 and the elastic member 33, it can keep the small animal with its head facing the fixed side of the funnel within an autonomous elastic range without spinning , so as to keep the connection of various detection equipment quiet and stable.
  • the auxiliary device for the detection of small animal physiological indicators adopts an open elastic fixation method to fix the small animal, so that the small animal can be naturally and elastically maintained in a quiet and stable state, thereby avoiding the stress response and Rotate freely, thereby avoiding entanglement or disconnection of various equipment cables connected to small animals, especially light-weight thin wires, which will not be bitten off by small animals or torn off due to small animals spinning and entangled. To reduce the foreign body sensation on small animals and smoothly connect various precision testing equipment.
  • the support structure 10 includes a support base 11, an L-shaped bracket 12 connected to the support base 11, and a support ring 13 connected to the L-shaped bracket 12.
  • the support part 21 is a cylindrical structure with an extension flange 211 extending from the top, the support part 21 is movably sleeved in the support ring 13, and can form the bottom surface of the extension flange 211 and the support In a state where the top surfaces of the ring 13 are supported, the device main body 20 can be movably supported on the support structure 10 .
  • the main body 20 of the device is movably supported on the L-shaped bracket 12, when the tail of the small animal is inside the funnel, the device can be adjusted by lifting the supporting part 21
  • the state of the main body 20 for example, can lift the main body 20 of the device obliquely, so as to induce small animals to actively climb and protrude their tails from the bottom opening 221 of the funnel 22 .
  • the posture of the small animal inside the device body 20 can be adjusted by adjusting the posture of the device body 20, so as to To meet the needs of different experiments, while avoiding the stress response of small animals caused by adjustment methods such as direct grasping.
  • the support part 21 has a top opening 212, so that the connecting wire of the external detection equipment can be introduced into the funnel part 22 through the top opening 212, and connected to the small animal.
  • the support structure 10 also includes a first support column 14 connecting the support base 11 and the tail root fixing ring 34 and a second support column 15 connecting the support base 11 and the tail sleeve tube 40 .
  • the tail root fixing ring 34 , the tail sleeve tube 40 and the support structure 10 are all preferably made of stainless steel.
  • the small animal used by the auxiliary device of the present invention to assist detection is a mouse, or other small animals, and the present invention does not limit the specific type of small experimental animals.
  • the specific dimensions of the auxiliary device for the detection of small animal physiological indicators are: the support base 11 is a cuboid structure with a length of 50 cm, a width of 30 cm, and a height of 8 cm.
  • the diameter of the top opening 212 of 20 is 13 cm
  • the depth of the support part 21 is 6.5 cm
  • the depth of the funnel part 22 is 12.5 cm.
  • the diameter of the bottom opening 221 is 1 cm
  • the distance between the bottom opening 221 and the support base 11 is 15 cm.
  • the auxiliary device for detecting physiological indicators of small animals may have other sizes, which are not limited in the present invention.
  • the small animal needs to move freely in the funnel 22 of the device main body 20 to get familiar with the environment of the funnel 22, for three consecutive days, about one hour per day.
  • the main body 20 of the device After the small animals are familiar with the main body 20 of the device, they will climb quietly and stay at the bottom of the funnel 22, some will actively extend their tails out of the bottom opening 221 of the funnel, and some will wrap their tails around the funnel. Inside, the main body 20 of the device can be raised separately and slightly tilted so that the small animal actively climbs and induces its tail to protrude from the opening 221 at the bottom of the funnel.
  • the tail passes through the tail root fixing ring 34, the tail is inserted into the tail sleeve tube 40, and the heat preservation pouch is assisted on the tail sleeve tube 40 to maintain a certain temperature, preferably close to the body temperature of the small animal.
  • the present invention also provides a method for using the auxiliary device for detecting physiological indicators of small animals in another aspect, including steps:
  • step S1 includes the steps of:
  • the device main body 20 is tilted and lifted so that the small animal actively climbs and induces its tail to stretch out through the bottom opening 221 of the funnel portion 22.
  • the method for using the auxiliary device for detection of small animal physiological indicators also includes the step: S5, after the small animal adapts to the connection line connected to the detection device, perform optogenetic stimulation, electrical stimulation, catheter administration, Any one or more of the experimental operations of catheter collection of body fluids, tail blood collection, and electromyography collection.
  • the auxiliary device for the detection of small animal physiological indicators has the following advantages:
  • the small animal is fixed in an open elastic fixing method, so that the small animal can be naturally and elastically kept in a quiet and stable state, thereby preventing the small animal from producing a stress response and spinning around freely;
  • the main body 20 of the device adopts a transparent material, so as to observe and record the real-time state of the small animal from multiple angles with the naked eye or an ordinary camera;
  • the tail of the small animal can be elastically stable in the described tail sleeve tube 40 kept within a certain temperature range, and the tail can be comfortably placed and convenient for experimental sampling operation;
  • the bottom opening 221 of the device main body 20 can facilitate the natural drop and extension of the tail of the small animal, and can also collect the excrement of the small animal in real time.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation, l'appareil comprenant une structure de support (10) et un corps principal d'appareil (20), un ensemble de fixation de racine de queue élastique (30) et un manchon de queue (40) supporté sur la structure de support (10). Le corps principal d'appareil (20) est constitué d'un matériau transparent, de telle sorte que l'état en temps réel d'un petit animal peut être observé de manière pratique et enregistré sous de multiples angles. Le corps principal d'appareil (20) est également pourvu d'une ouverture (221) au niveau de son fond, de telle sorte que la queue du petit animal peut s'étendre naturellement et que les excréments du petit animal puissent être collectés commodément en temps réel. L'ensemble de fixation de racine de queue élastique (30) fixe le petit animal dans un mode de fixation élastique non restreint, de telle sorte que le petit animal puisse conserver un état calme et stable dans le corps principal de l'appareil, ce qui permet d'empêcher le petit animal de subir une réaction de stress et de rouler librement, évitant l'enchevêtrement ou la déconnexion de divers fils de dispositif reliés au corps du petit animal. Le manchon de queue (40) peut rester dans une certaine plage de température, ce qui permet à la queue du petit animal d'être confortablement placée et de faciliter des opérations d'échantillonnage expérimental.
PCT/CN2021/136445 2021-12-08 2021-12-08 Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation WO2023102772A1 (fr)

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PCT/CN2021/136445 WO2023102772A1 (fr) 2021-12-08 2021-12-08 Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation

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PCT/CN2021/136445 WO2023102772A1 (fr) 2021-12-08 2021-12-08 Appareil pour faciliter la détection d'indicateurs physiologiques de petits animaux et son procédé d'utilisation

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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201341969Y (zh) * 2009-02-16 2009-11-11 王丽敏 大鼠代谢用多功能固定器
JP2011177331A (ja) * 2010-03-01 2011-09-15 Panasonic Corp 小動物用血圧呼吸測定装置
CN103222900A (zh) * 2013-05-22 2013-07-31 闫洪涛 大鼠固定器
CN103815982A (zh) * 2014-03-03 2014-05-28 中国人民解放军第三军医大学 一种小动物束缚装置
CN203749637U (zh) * 2014-03-18 2014-08-06 苏州大学 一种用于固定实验用小鼠尾巴进行静脉注射的装置
JP2020103683A (ja) * 2018-12-28 2020-07-09 国立研究開発法人産業技術総合研究所 注射針穿刺補助器具
CN211049691U (zh) * 2019-08-15 2020-07-21 贵州省人民医院 一种多功能实验鼠固定装置
CN211881626U (zh) * 2019-12-26 2020-11-10 徐州宏华玻璃科技有限公司 一种实验鼠应激实验束缚装置
CN213406414U (zh) * 2020-06-24 2021-06-11 云南农业大学 一种动物实验用固定架
KR20210117502A (ko) * 2020-03-19 2021-09-29 주식회사 바이탈스 혈액 채취가 가능한 마우스 홀더 장치
CN214549728U (zh) * 2020-12-01 2021-11-02 佳木斯大学 一种可移动式鼠尾固定器
CN114288056A (zh) * 2021-12-08 2022-04-08 中国科学院深圳先进技术研究院 一种用于小动物生理指标检测的辅助装置及其使用方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201341969Y (zh) * 2009-02-16 2009-11-11 王丽敏 大鼠代谢用多功能固定器
JP2011177331A (ja) * 2010-03-01 2011-09-15 Panasonic Corp 小動物用血圧呼吸測定装置
CN103222900A (zh) * 2013-05-22 2013-07-31 闫洪涛 大鼠固定器
CN103815982A (zh) * 2014-03-03 2014-05-28 中国人民解放军第三军医大学 一种小动物束缚装置
CN203749637U (zh) * 2014-03-18 2014-08-06 苏州大学 一种用于固定实验用小鼠尾巴进行静脉注射的装置
JP2020103683A (ja) * 2018-12-28 2020-07-09 国立研究開発法人産業技術総合研究所 注射針穿刺補助器具
CN211049691U (zh) * 2019-08-15 2020-07-21 贵州省人民医院 一种多功能实验鼠固定装置
CN211881626U (zh) * 2019-12-26 2020-11-10 徐州宏华玻璃科技有限公司 一种实验鼠应激实验束缚装置
KR20210117502A (ko) * 2020-03-19 2021-09-29 주식회사 바이탈스 혈액 채취가 가능한 마우스 홀더 장치
CN213406414U (zh) * 2020-06-24 2021-06-11 云南农业大学 一种动物实验用固定架
CN214549728U (zh) * 2020-12-01 2021-11-02 佳木斯大学 一种可移动式鼠尾固定器
CN114288056A (zh) * 2021-12-08 2022-04-08 中国科学院深圳先进技术研究院 一种用于小动物生理指标检测的辅助装置及其使用方法

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