WO2023092929A8 - 一种检测核黄素在角膜中渗透深度的方法及装置 - Google Patents
一种检测核黄素在角膜中渗透深度的方法及装置 Download PDFInfo
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- WO2023092929A8 WO2023092929A8 PCT/CN2022/087001 CN2022087001W WO2023092929A8 WO 2023092929 A8 WO2023092929 A8 WO 2023092929A8 CN 2022087001 W CN2022087001 W CN 2022087001W WO 2023092929 A8 WO2023092929 A8 WO 2023092929A8
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- riboflavin
- cornea
- image
- ciel
- penetration depth
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- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 8
- 210000004087 cornea Anatomy 0.000 title abstract 7
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 4
- 230000035515 penetration Effects 0.000 title abstract 4
- 229960002477 riboflavin Drugs 0.000 title abstract 4
- 235000019192 riboflavin Nutrition 0.000 title abstract 4
- 239000002151 riboflavin Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000003086 colorant Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/11—Region-based segmentation
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10024—Color image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30041—Eye; Retina; Ophthalmic
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Computer Vision & Pattern Recognition (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Quality & Reliability (AREA)
- Signal Processing (AREA)
- Eye Examination Apparatus (AREA)
- Image Analysis (AREA)
Abstract
本发明提供一种检测核黄素在角膜中渗透深度的方法，包括获取RGB彩色的眼刨面图像并转换到CIEL*a*b*彩色空间，且提取CIEL*a*b*彩色空间中亮度分量L*，进一步进行二值化及Blob形状分析，得到去除非角膜区域后的图像；基于去除非角膜区域后的图像及亮度分量L*图像，提取所有角膜前后表面边界点并进行曲线拟合，得到角膜前后表面曲线；将角膜前后表面曲线与CIEL*a*b*彩色空间进行图像融合，得到仅包含角膜区域的CIEL*a*b*彩色图像；在仅包含角膜区域的CIEL*a*b*彩色图像中，确定出核黄素渗透区域并分割出核黄素渗透点，且对所有核黄素渗透点进行曲线拟合及去除噪点，得到核黄素渗透深度及角膜前后表面曲线。实施本发明，能定量检测核黄素在角膜中的渗透深度，且直观准确。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111405728.9 | 2021-11-24 | ||
| CN202111405728.9A CN114399457A (zh) | 2021-11-24 | 2021-11-24 | 一种检测核黄素在角膜中渗透深度的方法及装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2023092929A1 WO2023092929A1 (zh) | 2023-06-01 |
| WO2023092929A8 true WO2023092929A8 (zh) | 2023-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2022/087001 WO2023092929A1 (zh) | 2021-11-24 | 2022-04-15 | 一种检测核黄素在角膜中渗透深度的方法及装置 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114399457A (zh) |
| WO (1) | WO2023092929A1 (zh) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100727935B1 (ko) * | 2005-05-24 | 2007-06-14 | 삼성전자주식회사 | 이미지 보정 방법 및 장치 |
| CN105893957B (zh) * | 2016-03-30 | 2019-03-22 | 上海交通大学 | 基于视觉湖面船只检测识别与跟踪方法 |
| CN108470348A (zh) * | 2018-02-13 | 2018-08-31 | 温州眼视光发展有限公司 | 裂隙灯眼前节断层图像特征提取方法 |
| CN111861977A (zh) * | 2020-05-27 | 2020-10-30 | 温州医科大学附属眼视光医院 | 一种基于机器视觉的眼前节断层图像的特征提取方法 |
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2021
- 2021-11-24 CN CN202111405728.9A patent/CN114399457A/zh active Pending
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2022
- 2022-04-15 WO PCT/CN2022/087001 patent/WO2023092929A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023092929A1 (zh) | 2023-06-01 |
| CN114399457A (zh) | 2022-04-26 |
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