WO2023074707A1 - Aliment améliorant l'obésité - Google Patents

Aliment améliorant l'obésité Download PDF

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Publication number
WO2023074707A1
WO2023074707A1 PCT/JP2022/039801 JP2022039801W WO2023074707A1 WO 2023074707 A1 WO2023074707 A1 WO 2023074707A1 JP 2022039801 W JP2022039801 W JP 2022039801W WO 2023074707 A1 WO2023074707 A1 WO 2023074707A1
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Prior art keywords
obesity
food
improving
cannabidiol
weight
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PCT/JP2022/039801
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English (en)
Japanese (ja)
Inventor
梓 鈴木
巌 堤
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シード医療製薬株式会社
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Priority to JP2023553143A priority Critical patent/JPWO2023074707A1/ja
Publication of WO2023074707A1 publication Critical patent/WO2023074707A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres

Definitions

  • the present invention relates to food for improving obesity.
  • hemp is known as a useful substance for multiple sclerosis, neuropathic pain, cancer, arteriosclerosis, obesity, metabolic syndrome, and diabetes.
  • Cannabidiol is a cannabinoid, but unlike tetrahydrocannabinol, which is known as a psychotropic drug, cannabidiol does not cause euphoria or euphoria, and is not abused, dependent, or tolerated. are compounded.
  • composition capable of promoting the obesity-improving action of cannabidiol in particular, a composition capable of improving obesity as part of a daily diet by being composed of ingredients that can be incorporated into foods has not yet been proposed. do not have.
  • the present invention has been made in view of such circumstances, and provides an obesity-improving food containing a slimming aid composition that promotes the obesity-improving action of cannabidiol.
  • the food for improving obesity includes (1) a food for improving obesity containing cannabidiol and a slimming aid composition that promotes the obesity-improving action of the cannabidiol.
  • the slimming aid composition is composed of an indigestible polymer compound and polyphenols.
  • the food for improving obesity also has the following characteristics.
  • the cannabidiol is contained in 100 parts by weight of the food for improving obesity in a proportion of 0.05 to 10 parts by weight.
  • the indigestible polymer compound contains at least one selected from dextrin, starch, protein, and dietary fiber.
  • the indigestible polymer compound is contained at a ratio of 3 to 50 parts by weight in 100 parts by weight of the food for improving obesity.
  • the polyphenols contain at least one selected from anthocyanin, ferulic acid, chlorogenic acid, catechin, and curcumin.
  • the polyphenols should be contained at a ratio of 1.5 to 20 parts by weight in 100 parts by weight of the food for improving obesity.
  • the dosage form is powder, fine granules, granules, soft capsules, hard capsules, jelly, gummy, liquid or tablet.
  • the obesity-improving food contains cannabidiol and a slimming aid composition that promotes the obesity-improving action of the cannabidiol, wherein the slimming aid composition comprises: Since it is composed of an indigestible polymer compound and polyphenols, it is possible to provide an obesity-improving food containing a slimming aid composition that promotes the obesity-improving action of cannabidiol.
  • cannabidiol when the cannabidiol is contained in 100 parts by weight of the food for ameliorating obesity at a ratio of 0.05 to 10 parts by weight, the obesity-improving action derived from cannabidiol can be enjoyed more steadily. .
  • the indigestible polymer compound contains at least one selected from dextrin, starch, protein, and dietary fiber, only the indigestible polymer compound other than these is included in the slimming aid composition. Compared with the case where it is blended as an ingredient, the obesity-improving action can be promoted more remarkably.
  • the indigestible polymer compound is contained at a ratio of 3 to 50 parts by weight in 100 parts by weight of the obesity-improving food, the obesity-improving action can be promoted more steadily.
  • the polyphenols contain at least one selected from anthocyanin, ferulic acid, chlorogenic acid, catechin, and curcumin, when only polyphenols other than these are blended as components of the slimming aid composition , the obesity-improving action can be promoted more remarkably.
  • the polyphenols are contained at a ratio of 1.5 to 20 parts by weight in 100 parts by weight of the obesity-improving food, the obesity-improving action can be promoted more steadily.
  • the dosage form is powder, granules, granules, soft capsules, hard capsules, jelly, gummies, liquids or tablets, people from the young to the elderly can consume obesity-improving food in dosage forms suitable for their age. It can be carried out.
  • FIG. 10 is an explanatory diagram showing the results of a confirmatory test of the promoting effect of the obesity-improving action of food A1 for improving obesity.
  • FIG. 3 is an explanatory diagram showing the results of confirmation test of the promoting effect of amelioration of obesity when the content of cannabidiol is changed.
  • FIG. 3 is an explanatory diagram showing the results of a confirmation test of the effect of promoting the obesity-improving action when the content of the indigestible polymer compound is changed.
  • FIG. 4 is an explanatory diagram showing the results of a test to confirm the effect of promoting the obesity-improving action when the content of polyphenols is changed.
  • the present invention relates to an obesity-improving food, and particularly to an obesity-improving food containing cannabidiol and a slimming aid composition that promotes the obesity-improving action of the cannabidiol.
  • CBD cannabidiol
  • cannabidiol is a component obtained from the seeds and stems of mature cannabis (Cannabis sativa L.), it tends to be misunderstood in Japan from the perspective of the Cannabis Control Law and is avoided as a food component. rice field.
  • cannabidiol is completely different from the so-called “marijuana and cannabis” that have stimulating effects as stipulated in the Cannabis Control Law.
  • “Cannabis” as defined in the Cannabis Control Law means flower heads and leaves of annual cannabis plants, or compounds with 21 carbon atoms derived from them. A representative of such components is tetrahydrocannabinol (THC), which is the main component of marijuana.
  • cannabidiol which is also used in the present invention, is a component that is completely different in structure and physiological action from tetrahydrocannabinol, and is a safe mature cannabis plant for industrial use that does not exhibit stimulant or psychoactive effects like marijuana.
  • Polyphenolic structures obtained from seeds or stems.
  • cannabidiol exerts various useful effects by acting on cannabidiol receptors throughout the body.
  • cannabidiol has already been commercialized in Japan by being incorporated into cosmetics and processed foods.
  • cannabidiol are specialized for the action of a single component of cannabidiol, and are not formulated from the synergistic viewpoint of the biological and physiological actions originally possessed by cannabidiol.
  • cannabidiol promotes the physiological functions of living organisms, and when commercializing cannabidiol preparations, it is necessary to promote metabolism, adjust the synaptic potential of the biological nervous system, and promote brain nerve transmission.
  • Prescription design that takes into account physiological metabolism promotion such as is important.
  • cannabidiol is a component that has the function of promoting and adjusting biologically active functions, and has a so-called trigger action that acts on physiologically active substances such as metabolic enzymes, neurotransmission functions, metabolic functions, and hormones that exist in living organisms. It has a mechanism.
  • cannabidiol in formulations aimed at improving obesity, cannabidiol cannot be expected to have the desired effect unless it acts on the cannabinoid receptors (CB1, CB2) scattered throughout the body.
  • the obesity-improving food according to the present embodiment can promote the obesity-improving effect of cannabidiol by blending cannabidiol with a slimming aid composition that promotes the obesity-improving effect of cannabidiol.
  • a slimming aid composition that promotes the obesity-improving effect of cannabidiol.
  • the slimming aid composition which is one of the characteristics of the food for improving obesity according to the present embodiment, is made up of an indigestible polymer compound and polyphenols. That is, the slimming aid composition can improve obesity as part of a daily diet because all constituent elements are food ingredients.
  • cannabidiol be contained at a rate of 0.05 to 10 parts by weight in 100 parts by weight of food for improving obesity.
  • cannabidiol By containing cannabidiol at such a concentration, the obesity improving effect derived from cannabidiol can be enjoyed more steadily.
  • the indigestible polymer compound is a compound that has been recognized as safe when taken orally in an appropriate amount as food, and has the property of being difficult to be decomposed by digestive enzymes. Dextrin, starch, protein or dietary fiber are preferred.
  • the indigestible polymer compound When the indigestible polymer compound is contained at a ratio of less than 3 parts by weight, it cannot sufficiently promote the obesity-improving action. Moreover, when it is contained at a rate exceeding 50 parts by weight, the obesity-improving action is not promoted in a concentration-dependent manner. Therefore, the indigestible polymer compound is desirably contained in a proportion of 3 to 50 parts by weight in 100 parts by weight of the food for improving obesity.
  • polyphenols are recognized as safe when taken orally in appropriate amounts as food, and are compounds in which two or more hydrogen atoms of aromatic hydrocarbons are substituted with hydroxyl groups.
  • it is a molecule having a plurality of phenolic hydroxyl groups or derivatives thereof, which are premised on safety in oral intake as described above, and is preferably anthocyanin, ferulic acid, chlorogenic acid, catechin, or curcumin.
  • Comparative foods X1 to X3 were also prepared. Comparative foods X1 to X3 are manufactured by the same method as obesity-improving food A1, but lack some raw materials.
  • the comparative food X1 is composed of 0.005 parts by weight of cannabidiol and 3.495 parts by weight of starch. It is a food that does not contain both ferulic acid and ferulic acid.
  • Comparative food X2 is composed of 0.005 parts by weight of cannabidiol, 0.105 parts by weight of indigestible dextrin, and 3.390 parts by weight of starch. It is a food that does not contain the constituent ferulic acid.
  • Comparative food X3 is composed of 0.005 parts by weight of cannabidiol, 0.053 parts by weight of ferulic acid, and 3.442 parts by weight of starch, and constitutes a slimming aid composition compared with food A1 for improving obesity.
  • the food does not contain indigestible dextrin.
  • Subjects were men and women in their 20s to 50s, 6 people (3 men, 3 women) in the group ingesting the obesity-improving food A1 (hereinafter referred to as the test group), and a group ingesting the comparative food X1 ( 6 persons (3 males, 3 females) in the first comparative group), and 6 persons (3 males, 3 females) in the group (hereinafter referred to as the second comparative group) ingesting food for comparison X2. 6 people (3 males and 3 females) in the group ingesting the comparative food X3 (hereinafter referred to as the 3rd comparison group), and 3 out of the 12 males and 12 females recruited. assigned randomly.
  • comparative groups 1 to 3 are also collectively referred to as comparative groups.
  • test group was asked to take 1 packet of obesity-improving food A1 30 minutes before dinner a day for 12 weeks.
  • the control group was also allowed to ingest one of the corresponding food products X1 to X3 for 12 weeks, one packet per day 30 minutes before dinner.
  • the subject in order for the subject to become accustomed to the environment in the test room under certain conditions (room temperature of 25 degrees, humidity of 50%), they first acclimatize for about 10 minutes. After acclimation, the subject stands barefoot on the measuring device and measures body fat according to the procedure of the measuring device.
  • each person when taking measurements, each person should bring appropriate clothing (such as a T-shirt or shorts), weigh the clothing before wearing it, and use the weight measurement value that is the basis for calculating the body fat percentage. I decided to deduct it. During the test period, the subjects were instructed to refrain from overeating and drinking and to maintain a regular lifestyle. The results are shown in FIG.
  • the second comparative group ingested the comparative food X2 containing cannabidiol and indigestible dextrin among the functional ingredients
  • the third comparative group ingested the comparative food X3 containing cannabidiol and ferulic acid.
  • a gradual decreasing trend was observed in changes in body fat percentage, almost the same as in Comparative Group 1.
  • the slimming aid composition contained in the obesity-improving food A1 according to the present embodiment promotes the obesity-improving action of cannabidiol.
  • Table 1 shows three types of foods with different cannabidiol contents.
  • the obesity-improving food B1 has a cannabidiol content of 1.75 mg, which is equivalent to 0.05 parts by weight when the total weight of the food is 100 parts by weight, compared to the previous formulation of the obesity-improving food A1. , and the other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the obesity-improving food C1 has a cannabidiol content of 350 mg, which is equivalent to 10 parts by weight when the total weight of the food is 100 parts by weight, compared to the previous prescription of the obesity-improving food A1. , and other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the obesity-improving food C2 has a cannabidiol content of 525 mg, which is equivalent to 15 parts by weight when the total weight of the food is 100 parts by weight. , and other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the obesity-improving food D1 has an indigestible dextrin content of 50 parts by weight when the total weight of the food is 100 parts by weight, as compared with the formulation of the obesity-improving food A1. It is an obesity-improving food with a total weight of 1,750 mg and adjusted with starch while maintaining the same content of other functional ingredients.
  • the obesity-improving food D2 has an indigestible dextrin content of 60 parts by weight when the total weight of the food is 100 parts by weight. It is an obesity-improving food with a weight of 2100 mg, with other functional ingredients having the same content and the total weight being adjusted with starch.
  • the obesity-improving food D3 has a content of indigestible dextrin equivalent to 1 part by weight when the total weight of the food is 100 parts by weight. It is an obesity-improving food with a total weight of 35 mg and adjusted with starch while maintaining the same content of other functional ingredients.
  • test method is the same as the above-mentioned "[1] Effect confirmation test with basic prescription", assigning 6 subjects, 3 men and 3 men, to each group, ingesting food for 12 weeks, each measurement Body fat percentage was measured daily. The results are shown in FIG.
  • the body fat percentage increased in both the groups ingesting the obesity-improving food B1 and the obesity-improving foods D1 and D2.
  • a significant decrease (p ⁇ 0.05) in the change in the weight loss is observed, and the indigestible polymer compound, indigestible dextrin, and the polyphenol, ferulic acid, act synergistically to function as a slimming aid composition.
  • the obesity improving effect of cannabidiol was promoted.
  • the obesity-improving food D3 which contains 35 mg of indigestible dextrin, which is equivalent to 1 part by weight when the total weight of the food is 100 parts, is the same as the comparative food X1, which contains only cannabidiol.
  • each functional component did not act synergistically, and the function as a slimming aid composition was not exhibited. .
  • the obesity-improving food F1 has a ferulic acid content of 700 mg, which is equivalent to 20 parts by weight when the total weight of the food is 100 parts by weight. , and other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the obesity-improving food F2 has a ferulic acid content of 1050 mg, which is equivalent to 30 parts by weight when the total weight of the food is 100 parts by weight, compared to the previous prescription of the obesity-improving food A1. , and other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the obesity-improving food F3 has a ferulic acid content of 35 mg, which is equivalent to 1 part by weight when the total weight of the food is 100 parts by weight, compared to the previous prescription of the obesity-improving food A1. , and other functional ingredients are the same, but the total weight is adjusted with starch to improve obesity.
  • the body fat percentage increased in both the groups ingesting the obesity-improving food B1 and the obesity-improving foods F1 and F2.
  • a significant decrease (p ⁇ 0.05) in the change in the weight loss is observed, and the indigestible polymer compound, indigestible dextrin, and the polyphenol, ferulic acid, act synergistically to function as a slimming aid composition.
  • the obesity improving effect of cannabidiol was promoted.
  • the content of ferulic acid is 35 mg, which is equivalent to 1 part by weight when the total weight of the food is 100 parts. This is a change in the body fat percentage, and as a result of the reduction in ferulic acid, each functional component did not act synergistically, and it was considered that the function as a slimming aid composition was not exhibited.
  • the obesity-improving food contains cannabidiol and a slimming aid composition that promotes the obesity-improving action of the cannabidiol, Since the slimming aid composition comprises an indigestible polymer compound and polyphenols, it is possible to provide an obesity-improving food containing a slimming aid composition that promotes the obesity-improving action of cannabidiol. can.

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  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
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Abstract

L'invention concerne un aliment améliorant l'obésité contenant une composition d'aide à l'amincissement qui favorise l'effet d'amélioration de l'obésité du cannabidiol.　Cet aliment améliorant l'obésité contient du cannabidiol et une composition d'aide à l'amincissement qui favorise l'effet d'amélioration de l'obésité du cannabidiol, la composition d'aide à l'amincissement étant constituée d'un composé polymère non digestible et d'un polyphénol. Le cannabidiol est caractérisé en ce qu'il est inclus dans l'aliment d'amélioration de l'obésité selon un rapport de 0,05 à 10 parties en poids du cannabidiol pour 100 parties en poids de l'aliment améliorant l'obésité.
PCT/JP2022/039801 2021-10-25 2022-10-25 Aliment améliorant l'obésité WO2023074707A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190133966A1 (en) * 2017-09-08 2019-05-09 Scicann Therapeutics Inc. Compositions comprising a cannabinoid and spilanthol
US20210015762A1 (en) * 2019-07-16 2021-01-21 TRUETIVA, Inc. Compositions for treating obesity
JP2021090453A (ja) * 2015-12-09 2021-06-17 ポビバ コーポレーションPoviva Corp. 脂溶性の活性物質を含む安定なレディ・トゥ・ドリンク飲料組成物
US20210251894A1 (en) * 2019-01-04 2021-08-19 Nutrition Therapeutics, Inc. Functional beverage compositions and methods of using and making same
WO2022024096A1 (fr) * 2020-07-31 2022-02-03 Ai Pharmaceuticals Jamaica Limited Compositions et procédés pour favoriser la perte de poids et pour le traitement de l'obésité

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021090453A (ja) * 2015-12-09 2021-06-17 ポビバ コーポレーションPoviva Corp. 脂溶性の活性物質を含む安定なレディ・トゥ・ドリンク飲料組成物
US20190133966A1 (en) * 2017-09-08 2019-05-09 Scicann Therapeutics Inc. Compositions comprising a cannabinoid and spilanthol
US20210251894A1 (en) * 2019-01-04 2021-08-19 Nutrition Therapeutics, Inc. Functional beverage compositions and methods of using and making same
US20210015762A1 (en) * 2019-07-16 2021-01-21 TRUETIVA, Inc. Compositions for treating obesity
WO2022024096A1 (fr) * 2020-07-31 2022-02-03 Ai Pharmaceuticals Jamaica Limited Compositions et procédés pour favoriser la perte de poids et pour le traitement de l'obésité

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