WO2023068437A1 - Écouteur sans fil ayant une fonction de stimulation du nerf vague - Google Patents

Écouteur sans fil ayant une fonction de stimulation du nerf vague Download PDF

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Publication number
WO2023068437A1
WO2023068437A1 PCT/KR2021/017087 KR2021017087W WO2023068437A1 WO 2023068437 A1 WO2023068437 A1 WO 2023068437A1 KR 2021017087 W KR2021017087 W KR 2021017087W WO 2023068437 A1 WO2023068437 A1 WO 2023068437A1
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WO
WIPO (PCT)
Prior art keywords
stimulation
user
nerve stimulation
wireless earphone
controller
Prior art date
Application number
PCT/KR2021/017087
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English (en)
Korean (ko)
Inventor
안우진
박대관
윤민수
민규식
이호승
Original Assignee
주식회사 토닥
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 토닥 filed Critical 주식회사 토닥
Publication of WO2023068437A1 publication Critical patent/WO2023068437A1/fr

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    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00—Details of transducers, loudspeakers or microphones
    • H04R1/10—Earpieces; Attachments therefor ; Earphones; Monophonic headphones
    • H04R1/1016—Earpieces of the intra-aural type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02438—Detecting, measuring or recording pulse rate or heart rate with portable devices, e.g. worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6815—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00—Details of transducers, loudspeakers or microphones
    • H04R1/10—Earpieces; Attachments therefor ; Earphones; Monophonic headphones
    • H04R1/1008—Earpieces of the supra-aural or circum-aural type
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R1/00—Details of transducers, loudspeakers or microphones
    • H04R1/10—Earpieces; Attachments therefor ; Earphones; Monophonic headphones
    • H04R1/1041—Mechanical or electronic switches, or control elements
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04R—LOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R2420/00—Details of connection covered by H04R, not provided for in its groups
    • H04R2420/07—Applications of wireless loudspeakers or wireless microphones

Definitions

  • the present application relates to wireless earphones having a vagus nerve stimulation function.
  • the vagus nerve one of the 12 cranial nerves, is a complex peripheral nerve that starts in the brain and extends from the brain through the neck and chest to the abdomen. It regulates body functions such as heart rhythm, body temperature, and blood pressure.
  • the vagus nerve stimulator can be used to maintain the homeostasis of the human body through the activation of the parasympathetic nerve, and can be used, for example, to treat conditions such as epilepsy, seizure, migraine, and stroke.
  • vagus nerve stimulators are mainly implemented as invasive stimulators requiring surgery, and their use is limited due to patients' reluctance.
  • non-invasive stimulators such as gammaCore that stimulates the vagus nerve by placing it on the neck and NEMOS that stimulates the vagus nerve by wired connection and fixation to the ear are typical examples.
  • one embodiment of the present invention provides a wireless earphone having a vagus nerve stimulation function.
  • the wireless earphone having the vagus nerve stimulation function includes an earphone unit inserted into the user's ear hole; an electrode unit protruding from one side of the earphone unit and contacting an inner part of the user's auricle (cymba conchae); and a controller that controls nerve stimulation applied to the user by the electrode unit, wherein the controller performs at least one of initial settings for nerve stimulation, adjustment of nerve stimulation, and feedback according to the user's state check.
  • the vagus nerve can be stimulated more conveniently and non-invasively by wearing a stimulator implemented in the form of a wireless earphone.
  • FIG. 1 is a conceptual diagram of a device for stimulating the vagus nerve wirelessly according to an embodiment of the present invention.
  • FIG. 2 is a diagram showing an embodiment of a wireless earphone having a vagus nerve stimulation function according to an embodiment of the present invention.
  • FIG. 3 is a view illustrating examples of viewing the wireless earphone shown in FIG. 2 from various angles.
  • FIG. 4 is a diagram showing an embodiment of a wireless earphone having a vagus nerve stimulation function according to another embodiment of the present invention.
  • FIG. 5 is a view showing examples of the wireless earphone shown in FIG. 4 viewed from various angles.
  • FIG. 6 is a block diagram of a wireless earphone having a vagus nerve stimulation function according to an embodiment of the present invention.
  • FIG. 7 is a flowchart illustrating a method of operating the wireless earphone shown in FIG. 6 .
  • FIG. 1 is a conceptual diagram of a device for stimulating the vagus nerve wirelessly according to an embodiment of the present invention.
  • a smart device 110 eg, a portable terminal, etc.
  • a stimulator 140 may be connected to a stimulator 140 through wireless communication 120, and through this, parameters for vagus nerve stimulation may be set.
  • adjustment or stimulation-related data eg, stimulation history data, etc.
  • the main parameters for stimulation include stimulation intensity (Amplitude), pulse width (width), and frequency (rate), and electrical signals are generated according to these values, so that stimulation suitable for the desired purpose can be applied to the human body.
  • a dedicated application for interworking with the stimulator 140 may be installed in the smart device 110, and the operation of the stimulator 140 may be controlled through the dedicated application.
  • the wireless communication 120 may be implemented with a low-power short-range communication technology such as, for example, Bluetooth Low Energy, and through this, control of the stimulator 140, data communication, and streaming functions may be performed. there is.
  • a low-power short-range communication technology such as, for example, Bluetooth Low Energy
  • the stimulator 140 may be implemented in a form wearable on the user's ear, such as a wireless earphone, and may non-invasively stimulate the vagus nerve by contacting the cymba conchae 10 to which the vagus nerve is connected. . As such, the stimulator 140 may be held by the user or fixed to the user's ear without a separate terminal connected by wire to stimulate the vagus nerve.
  • the stimulator 140 may be connected to the smart device 110 through wireless communication 120 to support an audio streaming function.
  • the stimulator 140 may additionally include a function of measuring a biosignal such as a user's heart rate, and the measurement data may be transmitted to the smart device 110 through wireless communication 120 .
  • FIG. 2 is a view showing an implementation example of a wireless earphone having a vagus nerve stimulation function according to an embodiment of the present invention
  • FIG. 3 is a view showing examples of the wireless earphone shown in FIG. 2 viewed from various angles. am.
  • an optimized structure is proposed so that the electrodes provided in the stimulator can be firmly attached to the cymba conchae, which is a stimulation point, so that electrical stimulation can be performed smoothly.
  • the wireless earphone 200 having a vagus nerve stimulation function includes an earphone unit 210 inserted into the user's ear canal and the earphone unit 210 It may include an electrode unit 230 that comes into contact with the cymba conchae of the user when worn, and an electrode support unit 220 that supports the electrode unit 230.
  • the earphone unit 210 may be implemented in the form of a commonly used earphone, a detailed description thereof will be omitted.
  • the electrode support part 220 protrudes from one side of the earphone part 210, and is inserted into the cymba conchae of the user's auricle to be formed in the form of an ear-hook so that it can be contacted and firmly fixed.
  • the electrode support 220 may be made of an elastic material such as silicon or elastomer so as to be deformable according to various ear shapes for each person.
  • the electrode part 230 may be formed at one point of the electrode support part 220, that is, at a position corresponding to the stimulation point of the inner part of the auricle (cymba conchae).
  • the electrode unit 230 may be made of a conductive metal and may be formed to protrude beyond the surface of the elastic material constituting the electrode support unit 220 . Through this, regardless of the shape and size of the user's ear, the electrode unit 230 can be tightly adhered to the stimulation point of the inner part of the auricle (cymba conchae).
  • FIG. 4 is a view showing an implementation example of a wireless earphone having a vagus nerve stimulation function according to another embodiment of the present invention
  • FIG. 5 is a view showing examples of the wireless earphone shown in FIG. 4 viewed from various angles. am.
  • a wireless earphone 300 having a vagus nerve stimulation function includes an earphone unit 310 inserted into a user's ear hole, and the earphone unit 310 It may be configured to include an electrode unit 320 formed to protrude from one side and contact the inner part of the user's auricle (cymba conchae).
  • the electrode support portion and the electrode portion are not formed separately, but the electrode portion 320 may be formed of a conductive flexible electrode made of an elastic material.
  • the electrode unit 320 may come into contact with the cymba conchae of the user's auricle.
  • FIG. 6 is a block diagram of a wireless earphone having a vagus nerve stimulation function according to an embodiment of the present invention.
  • the wireless earphone 410 having a vagus nerve stimulation function includes a nerve stimulation module 411, a speaker 412, a battery 413, and a DC power supply unit 414. , a controller 415, a heart rate sensor 416, and an antenna 417.
  • the wireless earphone 410 may be implemented as described above with reference to FIGS. 2 and 3 or 4 and 5 , and each component of the wireless earphone 410 is the wireless earphone shown in FIG. 2 or 4 . It can be contained within the housing of the earphone.
  • the nerve stimulation module 411 is for applying nerve stimulation under the control of the controller 415, and an electrode for applying the stimulation (corresponding to the electrode part shown in FIG. 2 or 4) and a signal for generating a stimulation signal It may be configured to include a generating unit and the like.
  • the speaker 412 is for outputting an audio signal streamed from the external terminal 418 .
  • the battery 413 is for charging power supplied from the cradle 421 and providing power for the operation of the wireless earphone 410 .
  • the DC power supply unit 414 is to receive DC power for operation from the cradle 421 .
  • the controller 415 is for controlling the entire operation of the wireless earphone 410, for example, as will be described later with reference to FIG. 7, initial settings for nerve stimulation, adjustment of nerve stimulation, and feedback according to the user's status check. At least one of these may be performed.
  • the heart rate sensor 416 is for measuring the user's heart rate, and may be placed in contact with the user's ear canal to enable energy-efficient heart rate sensing.
  • the antenna 417 is for performing communication with an external terminal 418 .
  • the wireless earphone 410 may be mounted on the cradle 421 for storage and charging.
  • the cradle 421 receives power from an external power source 425 and charges the wireless earphones 410 mounted on the cradle 421 by the wired charging unit 423 or the wireless charging unit 424, or the cradle battery 422. can be charged.
  • FIG. 7 is a flowchart illustrating a method of operating the wireless earphone shown in FIG. 6 .
  • the wireless earphones are removed from the cradle and worn on the user's ears, and a dedicated application installed on the user's smart device is executed, and then the application and the wireless earphones communicate wirelessly. It can be connected via
  • a switch provided in the wireless earphone may be touched or clicked, or an ON button may be clicked through an application installed in the smart device.
  • stimulation parameters such as stimulation intensity, pulse width, and frequency may be set to preset default values (eg, minimum values).
  • the stimulation parameter may be set to a value set at the time of previous use or a value previously set by the user.
  • a nerve stimulation signal may be applied according to the stimulation parameters set as described above.
  • a pre-stored tutorial mode may be performed to obtain basic values for nerve stimulation control.
  • a nerve stimulation signal may be applied while changing the stimulation intensity for a predetermined period of time (eg, several minutes), and the magnitude of the stimulation voltage may be measured.
  • a predetermined period of time e.g. several minutes
  • the magnitude of the stimulation voltage may be measured.
  • the stimulus intensity when the stimulus intensity is automatically increased by one step starting from the minimum stimulus intensity or gradually increased according to the user's input, when the user recognizes the stimulus for the first time and the stimulus intensity gradually increases Accordingly, an input may be received from each user at a point in time when pain is felt. Accordingly, the minimum value of the stimulation intensity may be set to the stimulation intensity at the time of first recognizing the stimulation, and the maximum value of the stimulation intensity may be set to the stimulation intensity at the time of feeling pain.
  • the above-described tutorial mode may proceed even when the wireless earphone is not used for the first time, that is, when reused after the initial setting has already been completed. In this case, the tutorial mode is constant for a preset time (eg, several minutes).
  • the magnitude of the stimulation voltage can be measured. Through this, it is possible to check the wearing state of the stimulator and calculate the impedance during stimulation.
  • the calculated average impedance value is compared with the pre-stored average impedance value, and if it is greater than the pre-stored average impedance value, the minimum and maximum values of the stimulus intensity set during the initial setting are reset by increasing by a predetermined step, and if it is smaller than the pre-stored average impedance value, the initial The minimum and maximum values of the stimulus intensity set during setup are reset by lowering them by a predetermined level, and the changed average impedance value can be stored.
  • one or more of stimulation parameters such as stimulation intensity, pulse width, and frequency may be adjusted through an application installed on the smart device, and a nerve stimulation signal may be applied according to the adjusted stimulation parameters.
  • the application may provide a plurality of pre-stored neurostimulation modes.
  • the stimulation parameter for each mode is preset to a preset value, and the user can adjust the stimulation parameter by selecting one of a plurality of nerve stimulation modes.
  • the application may provide a user with a questionnaire about a current state and a target state, and automatically determine an appropriate neurostimulation mode according to the user's input. For example, as shown in Table 1, the user selects one of a plurality of previously provided items for each of the user's current state and target state, and according to the selected item, the most appropriate neurostimulation mode among a plurality of pre-stored neurostimulation modes. can be automatically determined.
  • the first mode may be a relaxation mode inducing relaxation
  • the second mode may be a ready-to-sleep mode inducing sleep
  • the third mode may be acupuncture mode inducing arousal. Accordingly, stimulation parameters are preset to appropriate values. has been
  • the user may check the user's state through the application installed on the smart device and adjust the nerve stimulation accordingly.
  • the user may You can check the heart rate measured by the wireless earphone through the application. For example, when a user is wearing wireless earphones on both ears, a nerve stimulation signal may be applied through the wireless earphone worn on the left ear, and the user's heart rate may be monitored through the wireless earphone worn on the right ear.
  • heart rate data measured by a measuring device (eg, smart watch) possessed by the user may be provided separately from the wireless earphone.
  • the application or controller calculates an index for checking the stress state of the user based on heart rate data measured for a predetermined minimum time (eg, 1 minute) or more, and compares the calculated index with a predetermined reference value to stimulate stimulation.
  • intensity can be adjusted.
  • SDNN standard deviation of the NN interval
  • the SDNN interval is divided into a plurality of intervals, and the stimulation intensity is increased or decreased by a predetermined step depending on which interval the SDNN value belongs to. can give In this case, the lower the SDNN value, the higher the stimulation intensity, and the higher the SDNN value, the lower the stimulation intensity.
  • User status check and feedback as described above may be performed before nerve stimulation is performed (eg, in a tutorial mode) or while nerve stimulation is performed.
  • use may be terminated by touching or clicking a switch provided in the wireless earphone or clicking the OFF button through an application installed on the smart device.
  • use of the wireless earphone may be terminated by mounting the wireless earphone on the cradle.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
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  • Electrotherapy Devices (AREA)

Abstract

Un écouteur sans fil ayant une fonction de stimulation du nerf vague, selon un mode de réalisation de la présente invention, comprend : une unité d'écouteur qui est insérée dans le canal auditif d'un utilisateur ; une unité d'électrode qui fait saillie d'un côté de l'unité d'écouteur et entre en contact avec une partie interne du pavillon de l'oreille de l'utilisateur (cymba conchae) ; et un dispositif de commande qui commande la stimulation nerveuse appliquée à l'utilisateur par l'unité d'électrode, le dispositif de commande effectuant au moins l'un parmi les réglages initiaux pour la stimulation nerveuse, l'ajustement de la stimulation nerveuse et la rétroaction en fonction de la confirmation d'état de l'utilisateur.
PCT/KR2021/017087 2020-10-30 2021-11-19 Écouteur sans fil ayant une fonction de stimulation du nerf vague WO2023068437A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20200142734 2020-10-30
KR1020210140996A KR102512499B1 (ko) 2020-10-30 2021-10-21 미주신경자극 기능을 구비하는 무선 이어폰
KR10-2021-0140996 2021-10-21

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WO2023068437A1 true WO2023068437A1 (fr) 2023-04-27

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Publication number Priority date Publication date Assignee Title
KR20230162517A (ko) * 2022-05-20 2023-11-28 주식회사 뉴라이브 임피던스 측정을 반영한 미주신경에 대한 전기자극 인가 방법 및 미주신경 자극 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040000319A (ko) * 2002-06-24 2004-01-03 정종필 알파파유도 전기자극기
KR20170127958A (ko) * 2016-05-13 2017-11-22 주식회사 비에스엘 전기 자극 구조를 가진 히어링 디바이스
US20180339148A1 (en) * 2015-11-23 2018-11-29 The General Hospital Corporation System and method for ear-arranged transcutaneous vagus nerve stimulation
KR20200035053A (ko) * 2017-07-31 2020-04-01 더 파인스타인 인스티튜츠 포 메디칼 리서치 귀 자극 디바이스, 시스템 및 사용 방법
US20210069505A1 (en) * 2019-09-11 2021-03-11 Bose Corporation Wearable audio device with vagus nerve stimulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2981044A1 (fr) * 2015-03-27 2016-10-06 Elwha Llc Procede et systeme de stimulation auditive

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040000319A (ko) * 2002-06-24 2004-01-03 정종필 알파파유도 전기자극기
US20180339148A1 (en) * 2015-11-23 2018-11-29 The General Hospital Corporation System and method for ear-arranged transcutaneous vagus nerve stimulation
KR20170127958A (ko) * 2016-05-13 2017-11-22 주식회사 비에스엘 전기 자극 구조를 가진 히어링 디바이스
KR20200035053A (ko) * 2017-07-31 2020-04-01 더 파인스타인 인스티튜츠 포 메디칼 리서치 귀 자극 디바이스, 시스템 및 사용 방법
US20210069505A1 (en) * 2019-09-11 2021-03-11 Bose Corporation Wearable audio device with vagus nerve stimulation

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KR102512499B1 (ko) 2023-03-22

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