WO2023057966A1 - Sweetener formulations - Google Patents
Sweetener formulations Download PDFInfo
- Publication number
- WO2023057966A1 WO2023057966A1 PCT/IB2022/059586 IB2022059586W WO2023057966A1 WO 2023057966 A1 WO2023057966 A1 WO 2023057966A1 IB 2022059586 W IB2022059586 W IB 2022059586W WO 2023057966 A1 WO2023057966 A1 WO 2023057966A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- sweetener
- edible
- protein
- edible formulation
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 429
- 238000009472 formulation Methods 0.000 title claims abstract description 401
- 239000003765 sweetening agent Substances 0.000 title claims abstract description 273
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- 150000001299 aldehydes Chemical class 0.000 description 1
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- 229960004903 invert sugar Drugs 0.000 description 1
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- 150000002772 monosaccharides Chemical class 0.000 description 1
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- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
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- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/06—Products with modified nutritive value, e.g. with modified starch content
- A21D13/062—Products with modified nutritive value, e.g. with modified starch content with modified sugar content; Sugar-free products
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/18—Carbohydrates
- A21D2/181—Sugars or sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
Definitions
- the present invention relates to sweet formulations and, more particularly, to edible formulations including one or more egg proteins disposed in the sweetener particles.
- an edible formulation including: (a) sweetener particles containing at least one of a sweetener carbohydrate and a sweetener polyol; and (b) a first protein disposed within the sweetener particles, the first protein including an egg protein; wherein a weight-to-weight ratio of the first protein to the sweetener within the sweetener particles is within a range of 0.02% to 0.7%; and wherein the sweetener within the sweetener particles is predominantly crystalline.
- a food formulation containing the edible formulation; and additionally containing (b) a fat; (c) optionally, a starch; and (d) optionally, an edible filler; wherein a weight content of said first protein within the food formulation, on a dry basis, is within a range of 0.01% to 0.5%.
- sweetener formulations or “edible” formulations
- methods for making such improved sweetener formulations and utilizing them in food products may include one or more species of egg protein.
- sweetener formulations, or the egg protein within the formulations may exhibit any of various mucoadhesive properties.
- the inventors have discovered that the location of the protein within the food may be of cardinal importance, at least with respect to the sweetness thereof. Specifically, the inventors have discovered when protein such as egg protein is incorporated within the sweetener particles, the protein may not negatively impact food sweetness. In fact, the inventors have surprisingly discovered that under certain conditions (e.g., within a particular concentration range of the protein/egg protein), the presence of such protein/egg protein within the food may actually enhance food sweetness.
- mucoadhesion of the protein to the mucosa or mucous membranes on the tongue and within the oral cavity may contribute to the retention of sweetener carbohydrates and sweetener polyols, resulting in an enhanced and extended sensation of sweetness.
- This phenomenon occurs, or is greatly enhanced, when the protein/egg protein is incorporated within the sweetener particles, such that the mucosal adhesion between the mucin-containing mucosa and the protein in the sweetener particle helps to fix the sweetener particle to the oral mucosa, or to at least increase the contact time between the sweetener particle to the oral mucosa. This translates into increased activation of the sweetness sensors/receptor sites on the tongue, by way of example.
- the inventors have further surprisingly discovered that within a particular, low range of concentrations of proteins such as egg proteins disposed within the sweetener particles, the increased mucosal adhesion of the proteins appears to more than offset various properties of these proteins that may deleteriously affect taste, including perceived sweetness.
- These deleterious properties include the increased viscosity of the food (inter alia, reducing the solubility kinetics and hindering the transport of sweetener molecules to the sweetness sensors/receptor sites), covering and blocking oral sweetness sensors/receptor sites, and any non-sweet taste of the proteins.
- the presence of these proteins within the sweetener particles may impart appreciably enhanced sweetness to the food.
- the inventors have surprisingly discovered that while a moderate increase in the mucoadhesivity of the sweetener may result in increased sweetness in the sweetener or in food products utilizing such sweetener, a somewhat higher increase in the mucoadhesivity of the sweetener may counterintuitively result in decreased sweetness in the sweetener or in food products utilizing such sweetener.
- mucoadhesive agent refers to a substance exhibiting an affinity for attaching to a mucin layer of a mucosal surface of a human tongue, via mucoadhesion.
- sweetener carbohydrate refers to an edible sweetener having at least one carbohydrate moiety, which carbohydrate is processed within the human body to produce energy.
- This definition is meant to include sweetener carbohydrates having an energy value of at least 0.1 kcal/g, more typically, at least 0.2 kcal/g, more typically, at least 0.5 kcal/g, and yet more typically, at least 1.0 kcal/g. This definition is specifically meant to include allulose.
- sweetener carbohydrate is specifically meant to exclude high- intensity sweeteners such as sucralose, aspartame, and acesulfame-K.
- sweetener when used alone, is meant to include both sweetener carbohydrates and sweetener polyols.
- a sweetener carbohydrate produces a sweet taste when consumed by the typical human consumer. If, on a normalized sweetness scale, on a weight basis, in which sucrose is taken as a standard of 1, maltose is about 0.31, and lactose is about 0.22, the term “sweetener carbohydrate” would apply to lactose, and to any sugar or other nutritive, carbohydrate-containing sweetener having a sweetness within a range of 0.15 to 2.5 on this normalized sweetness scale. Alternatively, it may be stated that the minimum sweetness for the sugar or other nutritive, carbohydrate-containing sweetener would be that of raffinose (which has a sweetness of 0.15 on the above- mentioned scale).
- such a sweetener carbohydrate has a sweetness within a range of 0.25 to 2.5, 0.35 to 2.5, 0.45 to 2.5, 0.25 to 1.8, 0.45 to 1.7, 0.15 to 1.7, or 0.35 to 1.5 on this normalized sweetness scale.
- the term “sweetener carbohydrate” is meant to include fructose, irrespective of any of its reported relative sweetness values.
- the term “normalized sweetness scale”, refers to a relative sweetness scale, on a weight basis, in which sucrose is assigned a value of 1.00. More specifically, the normalized sweetness scale is determined according to the methods disclosed in Moscowitz, H. “Ratio Scales of Sugar Sweetness”; Perception & Psychophysics, 1970, Vol. 7 (5), in which the power function for the sugars and polyols/sugar alcohols has an exponent of 1.3 (n 1.3), as disclosed therein in Table 3, and as provided hereinbelow.
- a sweetener carbohydrate may be a monosaccharide or a disaccharide.
- sweetener carbohydrates include, but are not limited to, sucrose, glucose, maltose, fructose, lactose, or any combination of sweetener carbohydrates.
- One or more sweetener carbohydrate may be combined with one or more sweetener polyols.
- a sweetener carbohydrate may be naturally occurring or synthetically produced.
- sweetener polyol refers to a consumable polyol that produces a sweet taste when consumed by the typical human consumer.
- Non-limiting examples of sweetener polyols include xylitol, maltitol, erythritol, sorbitol, threitol, arabitol, hydrogenated starch hydrolysates (HSH), isomalt, lactitol, mannitol, or galactitol (dulcitol).
- the polyol is a sugar alcohol.
- a sugar alcohol can be produced from a carbohydrate by any known method of reduction (via a chemical or biological transformation) of an acid or aldehyde to an alcohol.
- a sweetener polyol can be synthesized from a parent carbohydrate.
- a sweetener polyol may be obtained from a biological source.
- sweetener polyol is meant to include any polyol/sugar alcohol having a sweetness within a range of 0.15 to 2.5 on the above-described normalized sweetness scale. More typically, such a sweetener polyol has a sweetness within a range of 0.15 to 1.5, 0.15 to 1.0, 0.15 to 0.8, 0.15 to 0.7, 0.20 to 0.7, 0.15 to 0.6, or 0.25 to 0.6, on this normalized sweetness scale.
- the proteins for use in accordance with the formulations and methods of the present invention may have various mucoadhesive properties.
- Mucoadhesion may generally refer to the attachment of particular macromolecules to a mucin layer of a mucosal surface of a human tongue.
- the mucoadhesive agent’s affinity for attaching to a mucin layer of a mucosal surface of a human tongue may be characterized or quantified by various characterization methods.
- mucoadhesion and “mucosal adhesion” refer to the tendency of a formulation, or of particular macromolecules (e.g., various proteins) to attach to a mucin layer of a mucosal surface of a human tongue.
- macromolecules e.g., various proteins
- mucoadhesive agent refers to a substance exhibiting an affinity for attaching to a mucin layer of a mucosal surface of a human tongue, via mucoadhesion.
- the mucoadhesive properties of the proteins for use in accordance with the formulations and methods of the present invention may have numerous hydrophilic groups, such as amine groups, methoxy groups, hydroxyl groups, etc., which may aid the attachment to mucus or cell membranes through various interactions such as hydrogen bonding and electrostatic interactions. Mucoadhesion may be promoted by various physical phenomena, including entanglement.
- the sweetener or edible formulations of the present invention may have a characteristically high degree of crystallinity.
- the sweetener in the sweetener formulations, as well as the food formulations utilizing such sweetener formulations, is predominantly crystalline. In some embodiments, the crystallinity is within a range of 70 to 100%.
- the crystallinity is within a range of 80 to 100%.
- the crystallinity is within a range of 90 to 100%.
- the crystallinity is within a range of 95 to 100%.
- Quantification of the degree of crystallinity, or of the relative quantities of amorphous sweetener vs. crystalline sweetener may be determined by various analytical procedures known to those skilled in the art, including, but not limited to, the following:
- IMC Isothermal microcalorimeter
- DSC Dynamic vapor sorption
- MTDSC Modulated temperature DSC
- HSC High speed DSC
- Raman spectroscopy ⁇ Near infrared spectroscopy (NIRS)
- SS-NMR Solid state nuclear magnetic resonance
- IIC Inverse phase gas chromatography
- sweetener carbohydrates and sweetener polyols are known to have reduced solubility kinetics (e.g., in water) with respect to their amorphous counterparts
- solubility kinetics e.g., in water
- sweetener carbohydrates and sweetener polyols are known to have reduced solubility kinetics (e.g., in water) with respect to their amorphous counterparts
- solubility kinetics e.g., in water
- sweetener polyols for sweetness enhancement is counterintuitive.
- the inventors have surprisingly discovered, however, that the highly crystalline, protein-containing sweetener particles of the present invention may produce an appreciably enhanced sweetness perception.
- the egg protein includes or mainly includes an albumin.
- the albumin includes or mainly includes ovalbumin. In some embodiments, the egg protein includes or mainly includes a lipoprotein.
- the lipoprotein includes or mainly includes a low density lipoprotein.
- the lipoprotein includes a high density lipoprotein.
- the at least one egg protein may be in the form of any one or any combination of egg protein, egg protein concentrate, and egg protein isolate.
- the at least one egg protein includes an integral protein, as defined hereinbelow.
- the at least one egg protein mainly or predominantly includes an integral protein.
- the at least one egg protein consists essentially of an integral protein.
- an edible filler material is typically utilized to make up the reduced amount of sugar in the food formulations of the present invention.
- the edible filler may be a dietary fiber or soluble fiber such as a soluble dietary fiber.
- the edible filler may be, or include, a polysaccharide, such as a fructan.
- a polysaccharide such as a fructan.
- fructans inulin may typically be used.
- the edible filler may be, or include, an oligosaccharide, such as a fructooligosaccharide.
- the soluble fiber may be, or include, resistant maltodextrin, e.g., soluble com fiber.
- the soluble fiber may be, or include, polydextrose.
- the sweetener formulation or edible formulation is typically devoid of silicon- containing species such as silica.
- the concentration of silicon within the sweetener formulation or edible formulation is at most 1%, at most 0.5%, at most 0.2%, at most 0.1%, at most 0.05%, at most 0.02%, at most 0.01%, at most 0.005%, or at most 0.003%.
- the concentration of silicon within the sweetener formulation or edible formulation is at most 0.002%, at most 0.001%, or the formulation is devoid of silicon.
- the protein and carbohydrate sweetener powders are mixed or blended.
- the resulting powder mixture is added gradually to water.
- the requisite amount of protein is calculated in ratio to the carbohydrate sweetener (weight-weight). For example: in order to prepare about 1 kilogram (typically 65°Bx) of syrup containing 0.1% protein with respect to the carbohydrate sweetener, 0.65 grams of the protein are mixed with 650 grams of the carbohydrate sweetener. This mixture is added gradually (under constant mixing) to 350 grams of water, typically at room temperature.
- the mixing vessel is stirred using an overhead stirrer, typically at 50-800 RPM for at least 45 minutes, or for at least 7 minutes using a high shear mixer (up to 10,000 RPM for IKA; up to 5,000 RPM for Silverson), until the protein is fully dispersed.
- an overhead stirrer typically at 50-800 RPM for at least 45 minutes, or for at least 7 minutes using a high shear mixer (up to 10,000 RPM for IKA; up to 5,000 RPM for Silverson), until the protein is fully dispersed.
- the water fraction may be pre- heated.
- a concentrated sweetener syrup containing one or more carbohydrate sweeteners and/or one or more polyol (typically sugar alcohol) sweeteners is prepared prior to the addition of the protein, from room temperature to as much as 80°C in some cases.
- the default temperature is 60°C for sucrose and any other di- saccharides, and 70°C for other sweetener species.
- the concentration is about 65wt% for most of the carbohydrate and polyol sweeteners. Some of the lower solubility sweeteners, may require higher water concentrations and/or temperatures in order to fully dissolve.
- the protein is then added incrementally or instantaneously under constant mixing.
- the mixing vessel continues to be stirred using an overhead stirrer, typically at 50-800 RPM for at least 45 minutes, or for at least 7 minutes using a high shear mixer (up to 10,000 RPM for IKA; up to 5,000 RPM for Silverson), until the protein is fully dispersed.
- an overhead stirrer typically at 50-800 RPM for at least 45 minutes, or for at least 7 minutes using a high shear mixer (up to 10,000 RPM for IKA; up to 5,000 RPM for Silverson), until the protein is fully dispersed.
- the syrup is heated to facilitate the dispersion of the protein.
- the protein is first dispersed in water. In some cases, the dispersion may be best performed according to the instructions of the manufacturer (e.g., dispersing incrementally in hot water).
- the sweetener (carbohydrate or polyol) is gradually introduced under constant mixing, from room temperature to as much as 80°C in some cases. The default temperature is 60°C for sucrose and any other di-saccharides, and 70°C for other sweetener species.
- Mixing may be effected by means of an overhead stirrer (50-800 RPM for at least 45 minutes) or by means of a high-shear mixer (up to 10,000 RPM for at least 7 minutes when using IKA; up to 5,000 RPM for at least 7 minutes when using the Silverson).
- EXAMPLE 4 Production of a Protein- Sweetener Dispersion — Partial Dispersion Partial dispersion of the protein may be deliberately effected.
- a concentrated sweetener syrup (carbohydrate or polyol) is prepared prior to the addition of the protein, as described in Example 2.
- the protein is then added in instantaneous or substantially instantaneous fashion, without mixing or with gentle mixing, typically up to about 1 minute, so as to deliberately produce small aggregates. In this manner, a concentrated syrup containing partially dispersed protein is produced.
- Concentrated syrup (e.g., produced in any of the above-provided examples) is transferred to the heated double-jacketed vessel of the vacuum dryer (e.g., Stephan).
- the vessel is heated (typically 60°C-70°C), maintained under vacuum (typically 50- 300 mbar), and mixed constantly, so as to evaporate the water, typically at a low rate of evaporation, so as to produce a predominantly or substantially 100% crystalline product.
- the powder may be transferred to an oven operating at 65°C for further drying for several hours or overnight.
- EXAMPLE 6 Size Reduction of the Protein- Sweetener Powder
- the protein-sweetener particles may optionally undergo size reduction.
- the protein-sweetener powder may be milled to produce a fine powder having a D50 that is typically within the range of 75 to 300 micrometers, depending on the particular protein(s) in the concentrate.
- the protein-sweetener formulation (e.g., as produced according to Example 3 and crystallized according to Example 5), is added as an ingredient, along with other ingredients, and may be mixed and optionally processed further (e.g., baked) to produce an edible (food) formulation (e.g., cake, muffins, biscuits).
- an edible (food) formulation e.g., cake, muffins, biscuits.
- a dispersion containing 0.02% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 0.13 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.05% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 0.33 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.1% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 0.65 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.3% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 1.95 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.5% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 3.25 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.65% egg albumen (Pulviver, Powder Sport Plus, 99% protein) was prepared according to Example 3: 4.2 grams of the egg albumen were dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the egg albumen dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.1% egg albumen (Pulviver, Powder Sport Plus, 99% protein) and 0.1% pea protein isolate (Nutralys® S85XF) was prepared according to Example 3 : 0.65 grams of the egg albumen and 0.65 grams of the pea protein isolate were simultaneously dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the protein dispersion to produce a concentrated syrup. The syrup was transferred to the heated double-jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- a dispersion containing 0.2% egg albumen (Pulviver, Powder Sport Plus, 99% protein) and 0.1% milk protein (calcium caseinate — Fonterra 380) was prepared according to Example 3 : 1.30 grams of the egg albumen and 0.65 grams of the calcium caseinate formulation were simultaneously dispersed in 350 grams water. Subsequently, 650 grams sucrose were added gradually to the protein dispersion to produce a concentrated syrup. The syrup was transferred to the heated double- jacketed vessel of the vacuum dryer, which was heated and maintained under vacuum according to Example 5, to produce a fine dry crystalline powder.
- the egg protein formulations of Examples 8 to 15 were prepared, but using fructose instead of sucrose.
- the egg protein formulations of Examples 8 to 15 were prepared, but using sorbitol instead of sucrose.
- the egg protein formulations of Examples 8 to 13 were prepared, but using hydrolyzed egg protein (James Wild Herbs) instead of egg albumen.
- the egg protein formulations of Examples 8 to 13 were prepared, but using xylitol instead of sucrose.
- Type I is a “full sugar” control muffin, which may be similar in composition to typical, commercially available muffins.
- Type II is an inventive, reduced-sugar muffin containing the inventive protein-sweetener or protein-sweetener concentrate.
- Type III is a reduced sugar control muffin, having the identical composition as the Type II inventive, reduced-sugar muffin, but being devoid of the protein in the sweetener particles.
- the batter for each type of muffin contains sugar, 14.2% sunflower oil, 21.8% wheat flour (containing approximately 68% starch), 24.5% eggs, baking powder (1.1%), flavors or flavorants (0.1%), salt (0.1%), and about 16.4% water.
- the batter of the Type I muffin contains 21.8 wt.% sugar.
- a fructooligosaccharide is used as a filler to make up for the reduced amount of sugar in the Type II and Type III samples.
- GofosTM typically containing 2% sugar
- the Type II muffin utilizes a sweetener formulation from various exemplary formulations (many of which are described or exemplified hereinabove). Aside from the formulative differences, the preparation and baking process is identical for the inventive muffin and the control muffins.
- the Type II inventive, reduced-sugar muffin contains 39.1% less sugar with respect to the Type I “full sugar” control muffin.
- the fructooligosaccharide (GofosTM) content of the muffin batter is about 8.5wt% (21.8% - 13.38%).
- the Type II inventive, reduced-sugar muffin may contain reduced sugar in an amount other than the typical reduction of 39.1%.
- the Type II muffin may contain 50% less sugar, 35% less sugar, 20% less sugar, or 10% less sugar.
- the Type II muffin contains at least 10% less sugar with respect to the Type I “full sugar” control muffin.
- EXAMPLE 45 Preparation of Butter Cookie Samples
- Type I is a “full sugar” control butter cookie, which may be similar in composition to typical, commercially available butter cookies.
- Type II is an inventive, reduced-sugar butter cookie containing the inventive protein-sweetener or protein-sweetener concentrate.
- Type III is a reduced sugar control butter cookie, having the identical composition as the Type II inventive, reduced-sugar butter cookie, but being devoid of the protein in the sweetener particles.
- the batter for each type of butter cookie contains sugar, 14.6% palm oil, 49.42% wheat flour (containing approximately 68% starch), corn starch (4.2%), water (5.7%), egg (3.6%), soy lecithin (0.19%), baking powder (0.3%), salt (0.2%), 1.2% invert sugar (containing 5% water), 1.5% heavy cream (containing 37% fat and 3.5% lactose), flavor or flavorants (0.1%), with water being the remainder.
- the sugar content of the Type I butter cookie is about 19.0%.
- Inulin is used as a filler to make up for the reduced amount of sugar in the Type II and Type III samples.
- Orafti High Soluble Inulin which contains 10% sugar is utilized.
- the Type II butter cookie utilizes a sweetener formulation from various exemplary formulations (many of which are described or exemplified hereinabove). Aside from the formulative differences, the preparation and baking process is identical for the inventive butter cookie and the control butter cookies.
- the Type II inventive, reduced-sugar butter cookie contains about 40% less sugar with respect to the Type I “full sugar” control butter cookie.
- the inulin content of the batter is about 7.7wt.% (19.0% - 11.3%).
- the Type II inventive, reduced-sugar butter cookie may contain reduced sugar in an amount other than the typical reduction of about 40%.
- the Type II butter cookie may contain 50% less sugar, 40% less sugar, 35% less sugar, 20% less sugar, or 10% less sugar.
- the Type II butter cookie contains at least 10% less sugar with respect to the Type I “full sugar” control butter cookie.
- Type I is a “full sugar” control hazelnut spread, which may be similar in composition to typical, commercially available hazelnut spreads.
- Type II is an inventive, reduced-sugar hazelnut spread containing the inventive protein-sweetener or protein-sweetener concentrate.
- Type III is a reduced sugar control hazelnut spread, having the identical composition as the Type II inventive, reduced-sugar hazelnut spread, but being devoid of the protein in the sweetener particles.
- Each type of hazelnut spread contains sugar, hazelnut paste (15%), palm oil (21.7%), cocoa powder (7.4%) having 12% fat, skim milk powder (6.6%), rapeseed lecithin (0.2%) and flavors or flavorants (0.1%).
- the sugar content of the Type I hazelnut spread is 49%.
- a fructooligosaccharide is used as a filler to make up for the reduced amount of sugar in the Type II and Type III samples.
- GofosTM is utilized.
- the Type II hazelnut spread utilizes a sweetener formulation from various exemplary formulations (many of which are described or exemplified hereinabove). Aside from the formulative differences, the preparation process is identical for the inventive hazelnut spread and the control hazelnut spreads.
- the Type II inventive, reduced-sugar hazelnut spread contains about 41% less sugar with respect to the Type I “full sugar” control hazelnut spread.
- the inulin content of the hazelnut spread is about 20.2 wt.% (49% - 29.4 %).
- the Type II inventive, reduced-sugar hazelnut spread may contain reduced sugar in an amount other than the typical reduction of about 40%.
- the Type II hazelnut spread may contain 50% less sugar, 35% less sugar, 20% less sugar, or 10% less sugar.
- the Type II hazelnut spread contains at least 10% less sugar with respect to the Type I “full sugar” control hazelnut spread.
- the exemplary sweetener or edible formulations may be evaluated by trained sensory panelists using a paired- comparison test.
- the paired-comparison test is a two-product blind test, and the panelists’ task is to choose/indicate the sweeter one of the two products or samples (Sensory Evaluation Practices, 4th Ed., Stone, Bleibaum, Thomas, eds.).
- the results are analyzed using binomial distribution tables, which allows the sensory scientist to determine whether perceived differences between the samples are statistically significant.
- a Comparative Sweetness Index may be calculated from the paired- comparison test results, compiled from all the panelists. For example, if, among 17 panelists, 10 chose the inventive product as being sweeter, while the other 7 panelists chose the comparative or control product, the Comparative Sweetness Index (CSI) would be calculated as:
- DME difference magnitude estimation
- a cookie is made from fat (palm oil, 17%), white wheat flour (61%), a sugar of the present invention (sucrose, 12%; 0.1% WPI), and a fructan (inulin, 10%).
- the only starch-containing ingredient is the white wheat flour, which contains about 68% starch.
- the starch content of the cookie is 68% of 61%, or about 41.5%.
- a hazelnut spread is made from fat (palm oil, 24%), a sugar of the present invention (sucrose, 30%; 0.1% rice protein formulation), pure hazelnut paste (13%, having a 61% fat content), non-fat milk powder (6%), cocoa powder (7% having a 12% fat content) and a fructan (inulin, 20%).
- the total fat content of the hazelnut spread is 24% + 61% of 13% + 12% of 7%, or about 32.8%.
- the mucoadhesion properties of sweetener formulations were evaluated by performing detachment tests using the TA.XTplus Texture Analyzer.
- the effect of various mucoadhesive species of egg protein on the adhesiveness of the sweetener formulation was also investigated, at various concentrations.
- Tablets made from various sweetener samples provided hereinabove, were prepared for detachment test using the Tableting Minipress Mil machine. "Dry Mix” samples were ground and mixed with magnesium stearate (as a lubricant) at 2 w/w% in a Tumble Mixer for 2 minutes. The mixture was introduced to the Minipress and pressed at an upper punch penetration of 11 mm, to produce flat tablets. The sweetener samples, produced according to Example 3 and further processed according to Example 5 (including further drying overnight), were pressed at a lower upper punch penetration of 7.5 - 9 mm. For all samples, the preparation rate was around 40 tablets/minute, in automatic mode. The diameter of the tablet is 10 mm.
- the trimmed pig tongue piece was pressure-fixed between a plastic platform and a lid, by means of four screws.
- a hole 13 mm in diameter, disposed in the middle of the lid, enables tablet-tongue contact.
- the plastic platform and pig tongue arrangement was maintained in the artificial saliva solution under constant temperature of 37°C.
- a sweetener tablet was attached to the Texture Analyzer (TA) probe (cylinder) by means of a double-sided adhesive tape. The measurement was performed using the following procedure: the probe, together with the tablet, was lowered at constant speed until a pre-determined applied force was exerted, for a fixed contact time, with the tongue tissue.
- TA Texture Analyzer
- detachment test procedure As used herein, the above-described detachment test procedure is referred to as a “standard detachment test”.
- Tablets of various sweetener samples were evaluated to determine the maximum detachment force and the work of detachment, using the equipment and procedures disclosed in Example 50.
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition, (i.e. , a formulation being devoid of the egg protein, but being otherwise identical to the sweetener formulation in both composition and preparation method).
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition by at least 1%, at least 1.5%, at least 2%, at least 3%, or at least 4%, and in some cases, at least 5%, at least 7%, at least 10%, at least 12%, or at least 15%.
- the inventors have further discovered that at relatively high levels of mucosal adhesion (e.g., as characterized by at least one of the maximum detachment force and the work of detachment), the presence of the protein/egg protein may actually be detrimental to the sweetness of the food or formulation, as perceived by taste-testing.
- mucosal adhesion e.g., as characterized by at least one of the maximum detachment force and the work of detachment
- the presence of the protein/egg protein may actually be detrimental to the sweetness of the food or formulation, as perceived by taste-testing.
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition by at most 200%, at most 150%, at most 100%, at most 80%, and more typically, at most 60%, at most 50%, at most 40%, at most 35%, or at most 30%.
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition by a value within a range of 1% to 200%, 1% to 120%, 1% to 80%, 1% to 60%, 1% to 40%, 1% to 30%, 1% to 25%, 1% to 20%, 1.5% to 60%, 1.5% to 40%, 1.5% to 30%, 1.5% to 25%, 1.5% to 20%, 2% to 200%, 2% to 120%, 2% to 80%, 2% to 60%, 2% to 50%, 2% to 40%, 2% to 30%, 2% to 25%, 2% to 20%,
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition, (i.e. , as above, a formulation being devoid of the egg protein, but being otherwise identical to the sweetener formulation in both composition and preparation method).
- the mucosal adhesion of the sweetener formulation, as characterized by the work of detachment is greater than that of the control composition by at least 1%, at least 1.5%, at least 2%, at least 3%, at least 5%, at least 7%, at least 10%, at least 20%, at least 30%, at least 40%, or at least 45%.
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition by at most 200%, at most 150%, at most 125%, at most 110%, at most 100%, at most 90%, at most 80%, at most 70%, at most 60%, or at most 50%.
- the mucosal adhesion of the sweetener formulation is greater than that of the control composition by a value within a range of 10% to 150%, 10% to 125%, 10% to 100%, 10% to 80%, 20% to 150%, 20% to 125%, 20% to 100%, 20% to 80%, 30% to 150%, 30% to 125%, 30% to 100%, 30% to 80%, 40% to 150%, 40% to 125%, 40% to 100%, 40% to 80%, 50% to 150%, 50% to 125%, 50% to 100%, or 50% to 90%.
- maximum detachment force (F Dmax ) refers to the maximum detachment force as measured by the standard detachment test.
- detachment work (W D ) refers to the work of detachment as measured by the standard detachment test.
- the term “work of detachment determination” (W D-D ) for a sweetener formulation containing a particular species of egg protein within the sweetener particles thereof refers to the work of detachment for the identical egg-protein-containing sweetener formulation, but having a concentration of 1% of that particular species of egg protein with respect to the sweetener, and prepared and measured according to the standard procedure of Example 50, the obtained detachment work (W D ) then being linearly applied using a coefficient K conc based on the actual concentration ( C actual ), in %, of that particular egg protein disposed within the sweetener particles of the formulation.
- the term “maximum force of detachment determination” (F D-D ) for a sweetener formulation containing a particular species of egg protein within the sweetener particles thereof refers to the maximum detachment force (F Dmax ) for the identical egg-protein-containing sweetener formulation, but having a concentration of 1% of that particular species of egg protein with respect to the sweetener, and prepared and measured according to the standard procedure of Example 50, the obtained maximum detachment force (F Dmax ) then being linearly applied using a coefficient K conc based on the actual concentration (C actual ), in %, of that particular species of egg protein disposed within the sweetener particles of the formulation.
- C actual actual concentration
- K conc C actual / 1 % (A)
- F D-D K conc ⁇ F Dmax (B)
- W D-D K conc ⁇ W D (C)
- mucosal adhesion and the like, with respect to a formulation, is meant to refer to mucosal adhesion as exhibited by at least one of maximum detachment force (F Dmax ), maximum force of detachment determination (F D-D ), detachment work (W D ), and work of detachment determination (W D-D ).
- F Dmax maximum detachment force
- F D-D maximum force of detachment determination
- W D detachment work
- W D-D work of detachment determination
- the mucoadhesive properties of egg protein were characterized using rheological measurements. It is known that the rheological behavior of the mixture containing the mucoadhesive egg protein and mucin may be appreciably influenced by chemical interactions, conformational changes and chain interlocking between the two species. Rheological techniques are used to study the deformation of material and their flow behavior under shear. Such measurement allows monitoring the interactions between polymers (Hassan and Gallo, 1990). Interactions between the mucoadhesive egg proteins and the mucin are manifested by viscosity enhancement, such that the viscosity of the mixture exceeds the sum of the individual viscosities of the mucin and the egg protein.
- the mucoadhesive force between the mucin and the egg protein may be characterized, according to the following equation: where is the total (measured) viscosity of the system (mixture), is the viscosity component of bioadhesion (viscosity enhancement) and are the individually- measured viscosities of mucin and egg protein single-component dispersions, respectively.
- an egg protein can be considered to be mucoadhesive, or to be a mucoadhesive agent, if the bioadhesion viscosity component as measured according to the standard procedure of Example 51 at a egg protein concentration of 1%, is at least 3 mPa ⁇ s. More typically, is at least 5 mPa ⁇ s, at least 7 mPa ⁇ s, or at least 10 mPa ⁇ s.
- this determination of mucoadhesivity i.e., whether the egg protein is considered to be mucoadhesive, or to be a mucoadhesive agent
- a standard rheological determination is referred to as a “standard rheological determination”.
- this bioadhesion viscosity component is within a range of 2- 400 mPa ⁇ s, 2.5-400 mPa ⁇ s, 2-350 mPa ⁇ s, 2.5-350 mPa ⁇ s, 3-400 mPa ⁇ s, 3-350 mPa ⁇ s, 3-300 mPa ⁇ s, 3-250 mPa ⁇ s, 3-200 mPa ⁇ s, 3-150 mPa ⁇ s, 4-400 mPa ⁇ s, 4-350 mPa ⁇ s, 4- 300 mPa ⁇ s, 4-250 mPa ⁇ s, 5-400 mPa ⁇ s, 5-350 mPa ⁇ s, 5-300 mPa ⁇ s, 5-250 mPa ⁇ s, 5- 200 mPa ⁇ s, 5-150 mPa ⁇ s, 6-400 mPa ⁇ s, 6-350 mPa ⁇ s, 6-300 mPa ⁇ s, 6-200 mPa ⁇ s, 6- 150 mPa ⁇ s, 7-200 mP
- bioadhesive concentration of egg protein refers to a particular concentration of at least one species of egg protein disposed within the sweetener particles of a formulation, the particular concentration of the at least one species of egg protein being sufficient to attain a value of at least 3 mPa ⁇ s for a bioadhesion viscosity component ( ⁇ b) , as measured according to the standard procedure of Example 51, but at that particular concentration.
- bioadhesive content of egg protein refers to an actual concentration (C actual ) of at least one species of egg protein disposed within the sweetener particles of the formulation, said actual concentration being sufficient to attain a bioadhesion viscosity increase ( ⁇ PS ) of at least 1.0 mPa ⁇ s, wherein the bioadhesion viscosity component ( ⁇ b ) is measured according to the standard procedure of Example 51 at a concentration of 1% egg protein, and then linearly applied to obtain ⁇ PS using a coefficient K conc based on the actual concentration (C actual ), in %, of the at least one species of egg protein disposed within the sweetener particles of the formulation:
- the formulation is deemed to have a bioadhesive content of egg protein.
- Embodiments 1 to 155 are provided hereinbelow.
- Embodiment 1 An edible formulation comprising:
- a first protein disposed within the sweetener particles including an egg protein; wherein a weight-to-weight ratio of the first protein to the sweetener within the sweetener particles is within a range of 0.02% to 0.7%; and wherein the sweetener within the sweetener particles is predominantly crystalline.
- Embodiment 2 The edible formulation of Embodiment 1, wherein a mucosal adhesion of the edible formulation is greater than that of a control formulation, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation, the mucosal adhesion of the edible formulation exceeding that of the control formulation by 3% to 200%.
- Embodiment 3 An edible formulation comprising:
- a first protein disposed within the sweetener particles the first protein including an egg protein; wherein a weight-to-weight ratio of the first protein to the sweetener within the sweetener particles is within a range of 0.02% to 0.7%; wherein a mucosal adhesion of the edible formulation is greater than that of a control formulation by 3 to 200%, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation.
- Embodiment 4 The edible formulation of Embodiment 2 or 3, wherein the mucosal adhesion of the edible formulation exceeds that of the control formulation by at most 125%.
- Embodiment 5 The edible formulation of Embodiment 4, wherein the mucosal adhesion of the edible formulation exceeds that of the control formulation by at most 100%, at most 75%, at most 50%, at most 40%, at most 30%, or at most 25%.
- Embodiment 6 The edible formulation of any one of Embodiments 3 to 5, wherein the mucosal adhesion of the edible formulation exceeds that of the control formulation by at least 4%, at least 5%, at least 6%, at least 7%, at least 10%, at least 15%, or at least 20%.
- Embodiment 7 The edible formulation of any one of the preceding Embodiments, wherein the sweetener has a sweetness of at least 0.25, on a normalized sweetness scale.
- Embodiment 7A The edible formulation of any one of the preceding Embodiments, wherein the sweetener includes, predominantly includes, or consists essentially of the sweetener carbohydrate.
- Embodiment 8 The edible formulation of Embodiment 7 A, wherein the sweetener carbohydrate is sucrose, or predominantly sucrose.
- Embodiment 9 The edible formulation of any one of the preceding
- Embodiments wherein the sweetener and the first protein make up at least 80% of the edible formulation.
- Embodiment 10 The edible formulation of any one of the preceding
- Embodiments wherein the egg protein makes up at least 25% of the first protein.
- Embodiment 11 The edible formulation of any one of the preceding
- Embodiments wherein the mucosal adhesion of the edible formulation is determined by a standard maximum detachment force determination.
- Embodiment 12 The edible formulation of any one of the preceding Embodiments, the mucosal adhesion of the edible formulation is determined by a standard work of detachment determination.
- Embodiment 12 A The edible formulation of any one of the preceding Embodiments, wherein the crystallinity of the sweetener particles is determined by quantitative XRD analysis such as XRPD.
- Embodiment 12B The edible formulation of any one of the preceding Embodiments, wherein the crystallinity of the sweetener particles is determined by isothermal microcalorimeter (IMC).
- IMC isothermal microcalorimeter
- Embodiment 12C The edible formulation of any one of the preceding Embodiments, wherein the crystallinity of the sweetener particles is determined by solution calorimetry.
- Embodiment 12D The edible formulation of any one of the preceding Embodiments, wherein the crystallinity of the sweetener particles is determined by differential scanning calorimetry (DSC).
- DSC differential scanning calorimetry
- Embodiment 12E The edible formulation of any one of the preceding Embodiments, wherein the crystallinity of the sweetener particles is determined by specific gravity measurement.
- Embodiment 13 An edible or food formulation comprising:
- Embodiment 14 The food formulation of Embodiment 13, containing at least 3% of the edible filler.
- Embodiment 15 The food formulation of Embodiment 13 or 14, wherein a total concentration of the fat, the edible filler, the starch, and any one of the edible formulation, the sweetener, and the sweetener particles, within the food formulation, is at least 30%.
- Embodiment 16 The food formulation of Embodiment 15, wherein this total concentration is at least 60%.
- Embodiment 17 The food formulation of any one of Embodiments 13 to 16, containing at least 10% of the fat, at least 10% of the starch, at least 5% of the edible filler, and at least 8% of any one of the edible formulation, the sweetener, and the sweetener particles.
- Embodiment 18 The food formulation of any one of Embodiments 13 to 17, containing at least 15% of the starch.
- Embodiment 19 The food formulation of any one of Embodiments 13 to 18, wherein a ratio of the sweetener in the sweetener particles to a total amount of sweetener in the food formulation is at least 50%.
- Embodiment 19A The food formulation of Embodiment 19, wherein the ratio is at least 65%.
- Embodiment 19B The food formulation of Embodiment 19, wherein the ratio is at least 75%.
- Embodiment 19C The food formulation of Embodiment 19, wherein the ratio is at least 85%.
- Embodiment 19D The food formulation of any one of Embodiments 13 to 19C, wherein the crystallinity of the total population of sweetener particles within the food formulation is at least 75%.
- Embodiment 19E The food formulation of Embodiment 19D, wherein the crystallinity of the total population of sweetener particles is determined by quantitative XRD analysis.
- Embodiment 19F The food formulation of Embodiment 19D, wherein the crystallinity of the total population of sweetener particles is determined by isothermal microcalorimeter (IMC).
- IMC isothermal microcalorimeter
- Embodiment 19G The food formulation of Embodiment 19D, wherein the crystallinity of the total population of sweetener particles is determined by solution calorimetry.
- Embodiment 19H The food formulation of Embodiment 19D, wherein the crystallinity of the total population of sweetener particles is determined by differential scanning calorimetry (DSC).
- DSC differential scanning calorimetry
- Embodiment 19 The food formulation of Embodiment 19D, wherein the crystallinity of the total population of sweetener particles is determined by specific gravity measurement.
- Embodiment 20 A method of producing the food formulation of any one of Embodiments 13 to 191, the method comprising:
- step (c) optionally subjecting the product of step (b) to an elevated temperature.
- Embodiment 20A The method of Embodiment 20, wherein the contacting includes mixing.
- Embodiment 20B The method of Embodiment 20 or 20 A, wherein the product of step (b) is subjected to an elevated temperature.
- Embodiment 21 An edible formulation comprising:
- Embodiment 21 A The edible formulation of Embodiment 21, wherein the first protein includes the egg protein.
- Embodiment 21B The edible formulation of Embodiment 21, wherein the first protein consists essentially of the egg protein.
- Embodiment 21 C The edible formulation of Embodiment 21, wherein the first protein mainly includes the egg protein.
- Embodiment 22 The edible formulation of any one of Embodiments 21 to 21C, wherein the sweetener is the sweetener carbohydrate.
- Embodiment 23 The edible formulation of any one of Embodiments 21 to 21C, wherein the sweetener is the sweetener polyol.
- Embodiment 24 The edible formulation of any one of Embodiments 21 to 23, wherein a total concentration of the sweetener and at least one fat within the edible formulation is at least 10%, on a weight basis.
- Embodiment 25 The edible formulation of any one of the preceding Embodiments, wherein the egg protein includes an albumin.
- Embodiment 26 The edible formulation of any one of the preceding Embodiments, wherein the egg protein includes a lipoprotein.
- Embodiment 27 The edible formulation of any one of the preceding Embodiments, wherein at least a portion of the egg protein is in the form of an egg protein concentrate.
- Embodiment 28 The edible formulation of any one of the preceding Embodiments, wherein at least a portion of the egg protein is in the form of an egg protein isolate.
- Embodiment 29 The edible formulation of any one of the preceding
- the egg protein includes at least one integral egg protein.
- Embodiment 30 The edible formulation of any one of the preceding
- the egg protein predominantly includes at least one integral egg protein.
- Embodiment 31 The edible formulation of any one of Embodiments 1 to 30, wherein the egg protein includes at least one partially-hydrolyzed egg protein.
- Embodiment 32 The edible formulation of any one of Embodiments 21 to 31, wherein a weight-to-weight ratio of the first protein or the egg protein to the sweetener within the sweetener particles is within a range of 0.02% to 1.5%.
- Embodiment 33 The edible formulation of any one of Embodiments 21 to 32, wherein the weight-to-weight ratio of the first protein or the egg protein within the sweetener particles is within a range of 0.005% to 0.7%.
- Embodiment 34 The edible formulation of any one of the preceding Embodiments, wherein a total concentration of the sweetener, a or the at least one fat, and a or the at least one starch, within the edible formulation, is at least 30%, on a weight basis.
- Embodiment 35 The edible formulation of any one of the preceding Embodiments, wherein a or the weight-to-weight ratio of the first protein or the egg protein to the sweetener within the sweetener particles is within a range of 0.03% to 0.7%.
- Embodiment 36 The edible formulation of any one of the preceding Embodiments, wherein a or the weight content of the first protein or the egg protein within the edible formulation, on a dry basis, is within a range of 0.005% to 0.5%.
- Embodiment 37 The edible formulation of any one of the preceding Embodiments, wherein an average particle size, by weight, of the sweetener particles within the edible formulation is at least 80 ⁇ m.
- Embodiment 38 The edible formulation of any one of the preceding Embodiments, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation, the control formulation being devoid of the first protein or the egg protein, but being otherwise identical to the edible formulation.
- Embodiment 39 The edible formulation of any one of the preceding Embodiments, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation by a value of at least 10%, and optionally, at least 20%, at least 30%, at least 40%, at least 50%, at least 75%, or at least 100%, the control formulation being devoid of the first protein or the egg protein, but being otherwise identical to the edible formulation.
- Embodiment 40 The edible formulation of any one of Embodiments 1 to 38, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation by a value of 5% to 200%, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation.
- Embodiment 41 The edible formulation of Embodiment 40, wherein the mucosal adhesion of the edible formulation is greater than that of the control formulation by a value of 3% to 90%.
- Embodiment 42 The edible formulation of Embodiment 40, wherein the mucosal adhesion of the edible formulation is greater than that of the control formulation by a value of 10% to 90%.
- Embodiment 43 The edible formulation of Embodiment 38, wherein the mucosal adhesion of the edible formulation is greater than that of the control formulation by a value of 3% to 50%, 3% to 30%, 5% to 50%, 10% to 50%, 15% to 90%, 15% to 80%, 15% to 70%, 15% to 50%, 20% to 90%, 20% to 70%, 25% to 90%, or 25% to 70%.
- Embodiment 44 The edible formulation of any one of Embodiment 42, wherein the mucosal adhesion of the edible formulation is greater than that of the control formulation by a value of 10% to 70%.
- Embodiment 45 The edible formulation of any one of the preceding Embodiments, wherein the a value of the mucosal adhesion of the edible formulation is determined by a standard maximum detachment force determination.
- Embodiment 46 The edible formulation of any one of the preceding
- Embodiments wherein a or the mucosal adhesion of the edible formulation is determined by a standard work of detachment determination.
- Embodiment 47 The edible formulation of any one of the preceding
- Embodiments wherein a total weight content of the sweetener particles within the edible formulation is at least 5%.
- Embodiment 48 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 8%.
- Embodiment 49 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 10%.
- Embodiment 50 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 15%.
- Embodiment 51 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 20%.
- Embodiment 52 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 25%.
- Embodiment 53 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 30%.
- Embodiment 54 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 40%.
- Embodiment 55 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 50%.
- Embodiment 56 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 65%.
- Embodiment 57 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 75%.
- Embodiment 58 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 85%.
- Embodiment 59 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 90%.
- Embodiment 60 The edible formulation of Embodiment 47, wherein the weight content of the sweetener is at least 95%.
- Embodiment 61 The edible formulation of any one of the preceding Embodiments, wherein a total weight content of the sweetener particles within the edible formulation is within a range of 8% to 80%.
- Embodiment 62 The edible formulation of Embodiment 61, wherein this total weight content is within a range of 10% to 70%.
- Embodiment 63 The edible formulation of Embodiment 61, wherein this total weight content is within a range of 15% to 70%.
- Embodiment 64 The edible formulation of any one of the preceding Embodiments, wherein the sweetener particles have an average particle size (D V 50) of at least 30 ⁇ m.
- Embodiment 65 The edible formulation of Embodiment 64, wherein D V 50 is within a range of 30 ⁇ m to 1500 ⁇ m.
- Embodiment 66 The edible formulation of Embodiment 64 or 65, wherein D V 50 is at least 50 ⁇ m.
- Embodiment 67 The edible formulation of Embodiment 66, wherein D V 50 is at least 100 ⁇ m.
- Embodiment 68 The edible formulation of Embodiment 66, wherein D V 50 is at least 200 ⁇ m.
- Embodiment 69 The edible formulation of Embodiment 66, wherein D V 50 is at least 350 ⁇ m.
- Embodiment 70 The edible formulation of any one of the preceding Embodiments, wherein the weight-to-weight ratio of the at least one egg protein to the sweetener within the sweetener particles is within a range of 0.03% to 0.7%, 0.03% to 0.6%, 0.03% to 0.5%, 0.05% to 0.7%, 0.1% to 0.65%, 0.1% to 0.6%, 0.2% to 0.7%,
- Embodiment 71 The edible formulation of any one of the preceding Embodiments, wherein the weight-to-weight ratio of the at least one egg protein to the sweetener within the sweetener particles is within a range of 0.1% to 0.7%.
- Embodiment 72 The edible (food) formulation of any one of the preceding Embodiments, wherein a or the weight content of the first protein within the edible formulation, on the dry basis, is at least 0.005%, at least 0.007%, at least 0.01%, at least 0.025%, at least 0.05%, at least 0.075%, at least 0.1%, at least 0.2%, or at least 0.3%, and at most 0.7%, or at most 0.6%.
- Embodiment 73 The edible (food) formulation of any one of the preceding Embodiments, wherein a or the weight content of the first protein within the edible formulation, on the dry basis, is within a range of 0.005% to 0.45%.
- Embodiment 74 The edible (food) formulation of Embodiment 73, wherein a or the weight content of the first protein within the edible formulation, on the dry basis, is within a range of 0.015% to 0.3%.
- Embodiment 75 The edible (food) formulation of Embodiment 73, wherein a or the weight content of the first protein within the edible formulation, on the dry basis, is within a range of 0.015% to 0.1%.
- Embodiment 76 The edible formulation of any one of the preceding Embodiments, wherein the sweetener carbohydrate is selected from at least one of the group consisting of sucrose, glucose, fructose, maltose, lactose, mannose, allulose, tagatose, xylose, galactose, arabinose, galactofructose.
- Embodiment 77 The edible formulation of any one of the preceding
- the sweetener carbohydrate includes sucrose.
- Embodiment 78 The edible formulation of any one of the preceding
- the sweetener carbohydrate includes or mainly includes glucose.
- Embodiment 79 The edible formulation of any one of the preceding Embodiments, wherein the sweetener carbohydrate includes or mainly includes fructose.
- Embodiment 80 The edible formulation of any one of the preceding
- Embodiment 81 The edible formulation of any one of the preceding
- Embodiments including a sweetener polyol or further including the sweetener polyol, wherein the sweetener polyol is selected from at least one of the group consisting of xylitol, maltitol, erythritol, sorbitol, threitol, arabitol, hydrogenated starch hydrolysates (HSH), isomalt, lactitol, mannitol, and galactitol (dulcitol).
- HSH hydrogenated starch hydrolysates
- Embodiment 82 The edible formulation of any one of the preceding Embodiments, wherein the formulation is in the form of a particulate solid such as a powder, e.g., a free-flowing powder.
- a particulate solid such as a powder, e.g., a free-flowing powder.
- Embodiment 83 The edible formulation of any one of the preceding Embodiments, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation by a first value of at least 5%, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation, the mucosal adhesion of the edible formulation and of the control formulation being determined by a standard work of detachment determination.
- Embodiment 84 The edible formulation of Embodiment 83, wherein the first value is at most 200%.
- Embodiment 85 The edible formulation of Embodiment 83, wherein the first value is within a range of 5% to 180%.
- Embodiment 86 The edible formulation of Embodiment 83, wherein the first value is within a range of 10% to 150%.
- Embodiment 87 The edible formulation of Embodiment 83, wherein the first value is within a range of 10% to 125%.
- Embodiment 88 The edible formulation of Embodiment 83, wherein the first value is within a range of 15% to 110%.
- Embodiment 89 The edible formulation of Embodiment 83, wherein the first value is within a range of 5% to 150%, 5% to 125%, 10% to 100%, 10% to 80%, 15% to 125%, 20% to 180%, 20% to 150%, 20% to 125%, 20% to 100%, 20% to 80%, 30% to 150%, 30% to 125%, 30% to 100%, 30% to 80%, 40% to 150%, 40% to 125%, 40% to 100%, 40% to 80%, 50% to 150%, 50% to 125%, 50% to 100%, or
- Embodiment 90 The edible formulation of any one of Embodiments 84 to 89, wherein the first value is at most 100%, at most 90%, at most 80%, at most 70%, at most 60%, at most 50%, or at most 40%.
- Embodiment 91 The edible formulation of any one of the preceding Embodiments, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation by a second value of at least 3%, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation, the mucosal adhesion of the edible formulation and of the control formulation being determined by a standard maximum detachment force determination.
- Embodiment 92 The edible formulation of Embodiment 91, wherein the second value is at most 150%.
- Embodiment 93 The edible formulation of Embodiment 91, wherein the second value is within a range of 3% to 125%.
- Embodiment 94 The edible formulation of Embodiment 91, wherein the second value is within a range of 5% to 125%.
- Embodiment 95 The edible formulation of Embodiment 91, wherein the second value is within a range of 5% to 100%.
- Embodiment 96 The edible formulation of Embodiment 91, wherein the second value is within a range of 5% to 75%.
- Embodiment 97 The edible formulation of Embodiment 91, wherein the second value is within a range of 5% to 50%.
- Embodiment 98 The edible formulation of Embodiment 91, wherein the second value is within a range of 5% to 35%.
- Embodiment 99 The edible formulation of Embodiment 91, wherein the second value is within a range of 7% to 50%.
- Embodiment 100 The edible formulation of Embodiment 91, wherein the second value is within a range of 7% to 25%.
- Embodiment 101 The edible formulation of Embodiment 91, wherein the second value is within a range of 10% to 50%.
- Embodiment 102 The edible formulation of Embodiment 91, wherein the second value is within a range of 3% to 100%, 3% to 60%, 3% to 40%, 7% to 100%, 7% to 80%, 7% to 70%, 7% to 60%, 7% to 40%, 8% to 60%, 8% to 40%, 8% to 30%, 10% to 80%, 10% to 60%, 10% to 35%, or 10% to 30%.
- Embodiment 103 The edible formulation of any one of Embodiments 91 to 102, wherein the second value is at most 65%, at most 60%, at most 55%, at most 50%, at most 45%, at most 40%, at most 35%, at most 30%, at most 25%, or at most 20%.
- Embodiment 104 The edible formulation of any one of the preceding Embodiments, wherein a or the mucosal adhesion of the edible formulation is greater than that of a control formulation by a first value of at least 5%, the control formulation being devoid of the first protein, but being otherwise identical to the edible formulation, the first value being determined by a standard work of detachment determination; and wherein a or the mucosal adhesion of the edible formulation is greater than that of the control formulation by a second value of at least 3%, the second value being determined by a standard maximum detachment force determination.
- Embodiment 105 The edible formulation of Embodiment 104, wherein the first value is within a range of 5% to 150%, and wherein the second value is within a range of 3% to 75%.
- Embodiment 106 The edible formulation of Embodiment 104, wherein the first value is within a range of 10% to 125%, and wherein the second value is within a range of 5% to 50%.
- Embodiment 107 An edible formulation comprising: (a) sweetener particles containing at least one sweetener selected from the group consisting of a sweetener carbohydrate and a sweetener polyol;
- a weight-to-weight ratio of the egg protein to the sweetener within the sweetener particles is within a range of 0.02% to 1.5%; and wherein a total concentration of the sweetener, the fat, and the starch, within the edible formulation, is at least 30%, on a weight basis.
- Embodiment 108 The edible formulation of any one of the preceding Embodiments, the edible formulation further comprising an or the edible filler.
- Embodiment 109 The edible formulation of any one of the preceding Embodiments, wherein a concentration of an or the edible filler within the edible formulation is at least 3.5%.
- Embodiment 110 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is at least 5%.
- Embodiment 111 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is at least 7%, at least 10%, at least 12%, or at least 15%.
- Embodiment 112. The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 3% to 35%.
- Embodiment 113 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 3% to 30%.
- Embodiment 114 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 5% to 30%.
- Embodiment 115 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 7% to 25%.
- Embodiment 116 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 10% to 35%.
- Embodiment 117 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 10% to 25%.
- Embodiment 118 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 12% to 25%.
- Embodiment 119 The edible formulation of Embodiment 109, wherein the concentration of the edible filler is within a range of 15% to 25%.
- Embodiment 120 The edible formulation of any one of the preceding Embodiments, wherein an or the edible filler within the edible formulation is a soluble fiber.
- Embodiment 121 The edible formulation of any one of the preceding Embodiments, wherein an or the edible filler within the edible formulation is a dietary fiber.
- Embodiment 122 The edible formulation of Embodiment 121, wherein the dietary fiber is a soluble dietary fiber.
- Embodiment 123 The edible formulation of any one of the preceding Embodiments, wherein an or the edible filler within the edible formulation is, or includes, a polysaccharide filler.
- Embodiment 124 The edible formulation of Embodiment 123, wherein the polysaccharide filler is, or includes, a fructan.
- Embodiment 125 The edible formulation of Embodiment 124, wherein the fructan is inulin.
- Embodiment 126 The edible formulation of Embodiment 124, wherein the fructan includes inulin.
- Embodiment 127 The edible formulation of any one of the preceding Embodiments, wherein an or the edible filler within the edible formulation is, or includes, an oligosaccharide.
- Embodiment 128 The edible formulation of Embodiment 127, wherein the oligosaccharide is, or includes, a fructooligosaccharide.
- Embodiment 129 The edible formulation of any one of the preceding Embodiments, wherein an or the soluble fiber within the edible formulation is, or includes, a resistant maltodextrin.
- Embodiment 130 The edible formulation of any one of the preceding Embodiments, wherein an or the soluble fiber within the edible formulation is, or includes, soluble com fiber.
- Embodiment 131 The edible formulation of any one of the preceding Embodiments, wherein an or the soluble fiber within the edible formulation is, or includes, polydextrose.
- Embodiment 132 The edible formulation of any one of the preceding Embodiments, wherein a total concentration of the sweetener and an or the fat is at least 10%, on a weight basis.
- Embodiment 133 The edible formulation of Embodiment 132, wherein the total concentration of Embodiment 132 is at least 15%, on the weight basis.
- Embodiment 134 The edible formulation of Embodiment 132, wherein the total concentration of Embodiment 132 is at least 20%, on the weight basis.
- Embodiment 135. The edible formulation of Embodiment 132, wherein the total concentration of Embodiment 132 is at least 25%, at least 30%, or a least 40%, on the weight basis.
- Embodiment 136 The edible formulation of any one of the preceding Embodiments, wherein a total concentration of the sweetener, an or the fat, and a or the starch within the edible formulation is at least 32%, on a weight basis.
- Embodiment 137 The edible formulation of Embodiment 136, wherein the total concentration of Embodiment 136 is at least 40%, on the weight basis.
- Embodiment 138 The edible formulation of Embodiment 136, wherein the total concentration of Embodiment 136 is at least 50%, on the weight basis.
- Embodiment 139 The edible formulation of Embodiment 136, wherein the total concentration of Embodiment 136 is at least 60%, on the weight basis.
- Embodiment 140 The edible formulation of any one of the preceding Embodiments, wherein a total concentration of the sweetener, an or the fat, a or the starch, and a or the edible filler within the edible formulation is at least 50%, on a weight basis.
- Embodiment 141 The edible formulation of Embodiment 140, wherein the total concentration of Embodiment 140 within the edible formulation is at least 55%.
- Embodiment 142 The edible formulation of Embodiment 140, wherein the total concentration of Embodiment 140 is at least 65%.
- Embodiment 143 The edible formulation of Embodiment 140, wherein the total concentration of Embodiment 140 within the edible formulation is at least 75%.
- Embodiment 144 The edible formulation of any one of the preceding Embodiments, wherein a concentration of cocoa powder within the edible formulation is at least 2%.
- Embodiment 145 The edible formulation of any one of the preceding Embodiments, containing at least 5% of the sweetener, at least 5% of a or the fat, and at least 5% of a or the starch.
- Embodiment 146 The edible formulation of Embodiment 145, containing at least 2% of a or the edible filler.
- Embodiment 147 The edible formulation of Embodiment 145 or 146, containing at least 10% of the sweetener, at least 10% of a or the fat, and at least 10% of a or the starch.
- Embodiment 148 The edible formulation of Embodiment 145, containing at least 5% of a or the edible filler.
- Embodiment 149 The edible formulation of Embodiment 145, containing at least 8% of a or the edible filler.
- Embodiment 150 The edible formulation of any one of the preceding Embodiments, wherein the egg protein makes up at least 40% of the first protein.
- Embodiment 151 The edible formulation of Embodiment 150, wherein the egg protein makes up at least 60% of the first protein.
- Embodiment 152 The edible formulation of Embodiment 150, wherein the egg protein makes up at least 80% of the first protein.
- Embodiment 153 The edible formulation of any one of the preceding
- the first protein includes a milk protein.
- Embodiment 154 The edible formulation of any one of the preceding
- the first protein includes a vegetable protein.
- Embodiment 155 The edible formulation of Embodiment 150, wherein the egg protein makes up all of the first protein.
- bioadhesive formulation As used herein in the specification and in the claims section that follows, the terms “bioadhesive formulation”, “bioadhesive sweet formulation” and the like refer to a formulation containing at least one of a bioadhesive concentration of egg protein and a bioadhesive content of egg protein.
- egg protein is meant to include any native protein found in eggs (from poultry), including egg protein in egg whites (albumen) and egg yolks.
- the term “egg protein” is also meant to include a denatured protein of egg protein or a modified protein of the egg protein, as will be appreciated by those of skill in the art.
- egg protein is further meant to include hydrolyzed egg proteins, such as an egg protein hydrolyzate or an egg white hydrolyzate.
- “Native” proteins may possess all four levels of biomolecular structure, wherein the secondary through quaternary structure may be formed from weak interactions along the covalently-bonded backbone.
- integral protein refers to a non-hydrolyzed or at most partially hydrolyzed protein.
- integral egg protein refers to a non-hydrolyzed or at most partially hydrolyzed egg protein.
- denatured protein does not include disruption to the primary protein structure, such as disruption to the sequence of amino acids held together by covalent peptide bonds.
- hydrolyzed protein refers to protein structures that have undergone such disruption to the primary protein structure, such as disruption to the sequence of amino acids held together by covalent peptide bonds.
- the term “mainly includes”, with respect to a component within a formulation refers to the major component within the formulation, on a weight basis.
- starch is meant to include edible starches that are used or may be used in foodstuffs. Typically, such starches include at least one of amylose and amylopectin, and more typically, both amylose and amylopectin.
- starch may be made, in order to impart to a particular foodstuff, or to the starch therein, specific chemical and/or physical properties, including, by way of example, the prevention of gelling at cold temperatures, withstanding low pH, or resistance to high shear or to high temperatures.
- starch is present in an ingredient, e.g., flour.
- the starch content is typically about 68%.
- the starch content is typically about 58%.
- fat is meant to include edible oils, including those that are liquid at room temperature, e.g., cooking oils. Specific examples of edible oils are olive oil, walnut oil, com oil, and cottonseed oil.
- Fats may be a separate ingredient, or may be an ingredient within a food ingredient.
- hazelnut paste and cocoa powder both contain fat.
- Average particle size may be based on the number of particles in the population (“D N 50”) or may be based on the volume of particles ( D V 50). These measurements may be obtained by various known methods including static light scattering (SLS), dynamic light scattering (DLS), sieving, and various methods of microscopy. Some methods may be preferred for larger ranges of particles, others may be preferred for smaller ranges of particles.
- the term “percent”, or “%”, refers to percent by weight, unless specifically indicated otherwise.
- the weight-percent of the protein is with respect to the sweetener.
- concentration refers to concentration on a weight basis, unless specifically indicated otherwise.
- ratio refers to a weight ratio, unless specifically indicated otherwise.
- the phrase “at least one of A and B” is equivalent to an inclusive “or”, and includes any one of “only A”, “only B”, or “A and B”.
- the phrase “at least one of A, B, and C” is equivalent to an inclusive “or”, and includes any one of "only A”, “only B”, “only C”, “A and B”, “A and C", “B and C”, or "A and B and C”.
Abstract
Description
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US202163253133P | 2021-10-07 | 2021-10-07 | |
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PCT/IB2022/050065 WO2022149072A1 (en) | 2021-01-05 | 2022-01-05 | Sweetener formulations |
US202263316015P | 2022-03-03 | 2022-03-03 | |
US63/316,015 | 2022-03-03 | ||
PCT/IB2022/057310 WO2023012741A1 (en) | 2021-08-05 | 2022-08-05 | Sweetener concentrate formulations |
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US20190021381A1 (en) * | 2015-08-28 | 2019-01-24 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US20190343155A1 (en) * | 2018-05-08 | 2019-11-14 | Weiyao Shi | Sweetener and flavor compositions, methods of making and methods of use thereof |
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US20190021381A1 (en) * | 2015-08-28 | 2019-01-24 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
US20190343155A1 (en) * | 2018-05-08 | 2019-11-14 | Weiyao Shi | Sweetener and flavor compositions, methods of making and methods of use thereof |
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