WO2023046169A1 - Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée - Google Patents
Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée Download PDFInfo
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- WO2023046169A1 WO2023046169A1 PCT/CN2022/121351 CN2022121351W WO2023046169A1 WO 2023046169 A1 WO2023046169 A1 WO 2023046169A1 CN 2022121351 W CN2022121351 W CN 2022121351W WO 2023046169 A1 WO2023046169 A1 WO 2023046169A1
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- Prior art keywords
- airway
- concentration
- concentration detection
- air
- alveolar gas
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000005259 measurement Methods 0.000 title abstract description 7
- 238000012544 monitoring process Methods 0.000 claims abstract description 42
- 238000001514 detection method Methods 0.000 claims description 74
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 52
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 35
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 35
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 26
- 239000001569 carbon dioxide Substances 0.000 claims description 25
- 230000009471 action Effects 0.000 claims description 5
- 239000003570 air Substances 0.000 description 85
- 230000029058 respiratory gaseous exchange Effects 0.000 description 9
- 239000012080 ambient air Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 230000003930 cognitive ability Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001595 flow curve Methods 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 238000013313 FeNO test Methods 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003434 inspiratory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/004—CO or CO2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0062—General constructional details of gas analysers, e.g. portable test equipment concerning the measuring method or the display, e.g. intermittent measurement or digital display
Definitions
- the present application relates to the technical field of breath collection, in particular to an alveolar gas concentration detection device and method for separating airways.
- Exhalation disease diagnosis technology is emerging as a new in vitro diagnostic technology that is parallel and complementary with blood test and imaging detection.
- breath diagnosis disease technology is highly regarded by researchers and clinicians at home and abroad. Pay attention, the blue ocean of the relevant market can reach the level of 100 billion. Therefore, institutions at home and abroad are scrambling to develop breath testing instruments.
- Existing breath testing instruments widely used clinically include breath testers for measuring red blood cell life span and Helicobacter pylori (Hp ) tester, exhaled nitric oxide (FENO) tester for detecting airway inflammation, etc. The use of these breath detection instruments is inseparable from the collection of breath.
- Hp Helicobacter pylori
- FENO exhaled nitric oxide
- the gas at the front end of exhalation is also called cavity air. Because it is directly connected to the atmospheric environment, it is generally mixed with more air, and the measurement is greatly affected by the environment; while the gas at the end of exhalation is basically alveolar gas, which is the After blood circulation, the gas that is directly excreted through alveolar gas exchange and can carry a large amount of health status information can best reflect the current health status of the human body.
- the purpose of the present invention is to provide an alveolar gas concentration detection device and method for isolated airways, which has high applicability and can meet the needs of continuous monitoring.
- the first technical solution adopted in the present invention is: a device for detecting alveolar gas concentration that separates the airway, comprising:
- the first airway the first airway includes an air inlet end and an air outlet end, the first airway is provided with a first electromagnetic valve, an air pump and a concentration detection module, and the air pump is arranged on the first electromagnetic valve Between the concentration detection module and the first solenoid valve, the first solenoid valve is arranged at the end of the first airway close to the inlet end, and the concentration detection module is arranged at the first airway close to the air outlet. end of end;
- the second airway, the second airway is provided with a state monitoring module, the state monitoring module is electrically connected to the first electromagnetic valve, and the state monitoring module is used to monitor the exhalation state.
- the air pump is arranged between the concentration detection module and the first solenoid valve, or the air pump is arranged on the side of the concentration detection module away from the first solenoid valve.
- the alveolar gas concentration detection device for separating airways also includes:
- a third air passage one end of the third air passage is connected between the first electromagnetic valve and the air pump, and a second electromagnetic valve is arranged on the third air passage.
- the concentration detection module includes a carbon dioxide sensor and a carbon monoxide sensor.
- a flow limiting module is set between the air pump and the concentration detection module.
- the flow limiting range of the flow limiting module is between 40mL/min-60mL/min.
- condition monitoring module includes a flow sensor or an air pressure sensor.
- the inlet end of the first airway and one end of the second airway are integrated into an exhalation collection module.
- the second technical solution adopted in the present invention is: a method for detecting alveolar gas concentration of separated airways, comprising:
- the breath is inhaled into the concentration detection module, and the concentration detection module detects the target gas concentration in the breath.
- the concentration detection module detects the target gas concentration in the breath, including:
- the carbon dioxide sensor and the carbon monoxide sensor in the concentration detection module record the carbon dioxide concentration and the carbon monoxide concentration in the breath in real time;
- the state monitoring module continues to monitor the exhalation state, and returns to the step of sending the first control signal to the first solenoid valve to open the first solenoid valve when the end of expiration is detected;
- the concentration of the carbon monoxide sensor is stable, the measured concentration of carbon monoxide in the alveolar gas is obtained, and the measured concentration of carbon monoxide in the alveolar gas is the target gas concentration.
- the device for detecting alveolar gas concentration with separated airways includes a first airway and a second airway.
- the first air passage includes an air inlet end and an air outlet end
- the first air passage is provided with a first electromagnetic valve, an air pump and a concentration detection module
- the first electromagnetic valve is arranged in the first air passage
- the concentration detection module is set at the end close to the air inlet end of the first airway;
- the second airway is provided with a state monitoring module, and the state monitoring module is connected to the air outlet.
- the first electromagnetic valve is electrically connected, and the state monitoring module is used to monitor the exhalation state.
- the alveolar gas concentration detection device for separating the airway has high applicability and can meet the requirement of continuous monitoring.
- Fig. 1 is a schematic structural diagram of an alveolar gas concentration detection device for separating airways provided in an embodiment of the present application.
- Fig. 2 is another structural schematic diagram of the alveolar gas concentration detection device for separating the airways provided by the embodiment of the present application.
- Fig. 3 is a comparative waveform curve of the concentration and flow rate of carbon dioxide provided by the embodiment of the present application.
- Fig. 4 is a schematic flow chart of a method for detecting alveolar gas concentration in an isolated airway provided in an embodiment of the present application.
- FIG. 1 is a schematic structural diagram of an alveolar gas concentration detection device for separating airways provided in an embodiment of the present application.
- the device for detecting alveolar gas concentration with separated airways may include a first airway 10 and a second airway 20 .
- the first air channel 10 includes an air inlet end A and an air outlet end B.
- the first air channel 10 is provided with a first solenoid valve 11 , an air pump 12 and a concentration detection module 13 .
- the first solenoid valve 11 is disposed at an end of the first air passage 10 close to the intake end A.
- the concentration detection module 13 is arranged at the end of the first air passage 10 close to the air outlet B.
- a state monitoring module 21 is arranged on the second airway 20 .
- the state monitoring module 21 is electrically connected with the first solenoid valve 11 .
- the intake end A of the first airway 10 and one end of the second airway 20 are integrated into an exhalation collection module.
- an exhalation collection module Such as nasal cannula, exhalation mask, etc.
- the air pump 12 can be disposed between the first solenoid valve 11 and the concentration detection module 13 .
- the air pump 12 can also be arranged on the side of the concentration detection module 13 away from the first electromagnetic valve 11 .
- the air pump 12 is electrically connected to the state detection module 21 .
- the state monitoring module 21 can be used to monitor the exhalation state.
- the condition monitoring module 21 may include a flow sensor or an air pressure sensor.
- the alveolar gas concentration detection device for the separated airway can also include a third airway 30, one end of the third airway 30 is connected between the first electromagnetic valve 11 and the air pump 12, and the third airway 30 A second solenoid valve 31 is provided on it.
- the third air channel 30 communicates with the air, and the third air channel 30 can be used to detect the gas concentration in the air.
- the concentration detection module 13 may include a carbon dioxide sensor 131 and a carbon monoxide sensor 132 .
- the carbon dioxide sensor 131 is disposed at the end of the first air passage 10 close to the intake end A, and the carbon monoxide sensor 132 is disposed at the end of the first air passage 10 close to the air discharge end B. It should be noted that the relative positions of the carbon dioxide sensor 131 and the carbon monoxide sensor 132 can be interchanged.
- a flow limiting module 14 is provided between the air pump 12 and the concentration detection module 13 .
- the gas flow limitation range of the flow limiting module 14 is between 40mL/min-60mL/min.
- the gas flow restriction of the flow restriction module 14 is 50mL/min.
- the flow limiting module 14 may include a flow limiting valve or a capillary.
- the flow limiting module 14 can be used to detect the gas flow rate entering the concentration detection module 13 .
- the state detection module 21 may also include a control unit, which may be electrically connected to various components in the alveolar gas concentration detection device for separating the airways provided in the embodiment of the present application, so as to realize the signal control.
- a control unit which may be electrically connected to various components in the alveolar gas concentration detection device for separating the airways provided in the embodiment of the present application, so as to realize the signal control.
- the exhalation collection module integrated with the intake end A of the first airway 10 and one end of the second airway 20 can be connected to the patient's oral cavity or nasal cavity . It should be noted that, at this moment, the first solenoid valve 11 is in a closed state. Then, the exhalation state is monitored through the state monitoring module 21 on the second airway 20 .
- the state monitoring module 21 When the state monitoring module 21 detects the onset of end-expiration, it can send a first control signal to the first solenoid valve 11 to make the first solenoid valve 11 open. At this time, under the action of the air pump 12, breath is inhaled into the concentration detection module 13, and the carbon dioxide sensor 131 and carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and carbon monoxide concentration in real time.
- the state monitoring module 21 When the state monitoring module 21 detects that the end of exhalation is over, it can send a second control signal to the first solenoid valve 11 to close the first solenoid valve 11 . Then, the state monitoring module 21 continues to monitor the exhalation state, and returns to the step of sending the first control signal to the first solenoid valve 11 to open the first solenoid valve 11 when the end of expiration is detected.
- a third airway 30 may be provided in the alveolar gas concentration detection device of the separated airway.
- one end of the third air passage 30 is connected between the first solenoid valve 11 and the air pump 12
- the third air passage 30 is provided with a second solenoid valve 31 .
- One end of the third air channel 30 is connected between the first electromagnetic valve 11 and the air pump 12
- the second electromagnetic valve 31 is arranged on the third air channel 30 .
- the second solenoid valve 31 can be opened before the end of expiration, or after the end of expiration. Under the action of the air pump 12, the air is sucked into the concentration detection module 13, the carbon dioxide sensor 131 and the carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and the carbon monoxide concentration in real time at this moment, when the carbon monoxide sensor 132 After the reading is stable, the carbon monoxide concentration C3 in the air is obtained.
- the air pump 12 is always on.
- the carbon dioxide concentration waveform under normal breathing conditions can be as shown in FIG. 3 . Indicating the state of respiration through the carbon dioxide concentration curve can better distinguish the various stages of exhalation.
- the change in the CO2 concentration curve is due to the mixing of ambient air and alveolar air.
- the carbon dioxide concentration in the inhalation section reflects the carbon dioxide concentration in the environment, and the gas in the inhalation section can be considered as ambient air.
- the initial expiratory phase can be regarded as the proportional mixture of the ambient air in the inspiratory phase and the alveolar gas in the final expiratory phase.
- the air in the early part of exhalation can also be considered cavity air.
- the detection of end-tidal carbon monoxide concentration is essentially the detection of carbon monoxide concentration at the end of expiration.
- the breathing curve can not only be reflected by the carbon dioxide concentration curve, but also can be better reflected by sensors such as flow sensor/barometric pressure sensor.
- the advantage of the flow sensor/air pressure sensor is that the flow sensor reflects the state of breathing by detecting the breathing pressure, and can eliminate the interference caused by the change of gas composition in the air.
- the key is that the transmission speed of the air pressure is extremely fast, and the response time of the flow sensor (air pressure sensor) is extremely short. For people with a high respiratory rate, it can more accurately reflect the changes in the breathing curve.
- the concentration detection module 13 in the alveolar gas concentration detection device of the separated airway can be removed, and then an air bag 15 is installed on the air outlet B to collect the end-tidal gas gas. Then, the concentration of the end-tidal gas in the air bag 15 is detected by the gas sensor, so as to realize the off-line detection of the end-tidal gas.
- FIG. 4 is a schematic flowchart of a method for detecting alveolar gas concentration in separated airways provided in an embodiment of the present application.
- the method for detecting alveolar gas concentration of separated airways is applied to the device for detecting alveolar gas concentration of separated airways in the above embodiments.
- the specific flow of the method for detecting the alveolar gas concentration of the separated airway can be as follows:
- the state monitoring module 21 detects the start of end-expiration, send a first control signal to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are turned on.
- the breath is sucked into the concentration detection module 13, and the concentration detection module 13 detects the target gas concentration in the breath.
- the step "the concentration detection module 13 detects the concentration of the target gas in the breath” may include:
- the carbon dioxide sensor 131 and the carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and the carbon monoxide concentration in the breath in real time;
- a second control signal is sent to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are closed;
- the state monitoring module 21 continues to monitor the exhalation state, and when it detects that the end of exhalation begins, it returns to the process of sending the first control signal to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are opened. step;
- the concentration of the carbon monoxide sensor 132 is stable, the measured concentration of carbon monoxide in the alveolar gas is obtained, and the measured concentration of carbon monoxide in the alveolar gas is the target gas concentration.
- the device for detecting alveolar gas concentration with separated airways includes a first airway 10 and a second airway 20 .
- the first air channel 10 includes an air inlet end A and an air outlet end B.
- the first air channel 10 is provided with a first solenoid valve 11 , an air pump 12 and a concentration detection module 13 .
- the first solenoid valve 11 is disposed at an end of the first air passage 10 close to the intake end A.
- the concentration detection module 13 is arranged at the end of the first air passage 10 close to the air outlet B.
- a state monitoring module 21 is arranged on the second airway 20 .
- the state monitoring module 21 is electrically connected with the first electromagnetic valve 11, and the state monitoring module 21 is used for monitoring the exhalation state.
- the alveolar gas concentration detection device for separating the airway has high applicability and can meet the requirement of continuous monitoring.
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Abstract
L'invention concerne un appareil et un procédé de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée. L'appareil de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée comprend des première (10) et seconde (20) voies respiratoires. La première voie respiratoire (10) comprend une extrémité d'entrée d'air (A) et une extrémité de sortie d'air (B); la première voie respiratoire (10) est pourvue d'une première vanne électromagnétique (11), d'une pompe à air (12) et d'un module de mesure de la concentration (13); la première vanne électromagnétique (11) est disposée à l'extrémité de la première voie respiratoire (10) à proximité de l'extrémité d'entrée d'air (A); et le module de mesure de la concentration (13) est disposé à l'extrémité de la première voie respiratoire (10) à proximité de l'extrémité de sortie d'air (B). La seconde voie respiratoire (20) est pourvue d'un module de surveillance d'état (21); le module de surveillance d'état (21) est connecté électriquement à la première vanne électromagnétique (11); et le module de surveillance d'état (21) est utilisé pour surveiller un état d'expiration. L'appareil de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée présente une grande applicabilité et peut satisfaire les exigences d'une surveillance continue.
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CN202111138173.6 | 2021-09-27 | ||
CN202111138173.6A CN113777244A (zh) | 2021-09-27 | 2021-09-27 | 分离气道的肺泡气浓度检测装置及方法 |
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PCT/CN2022/121351 WO2023046169A1 (fr) | 2021-09-27 | 2022-09-26 | Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée |
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CN113777244A (zh) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | 分离气道的肺泡气浓度检测装置及方法 |
CN218035914U (zh) * | 2022-06-14 | 2022-12-13 | 惠雨恩科技(深圳)有限公司 | 一种呼气末采集装置 |
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CN109602420A (zh) * | 2018-11-23 | 2019-04-12 | 深圳市美好创亿医疗科技有限公司 | 呼出气体检测设备及检测方法 |
CN113777244A (zh) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | 分离气道的肺泡气浓度检测装置及方法 |
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