WO2023046169A1 - Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée - Google Patents

Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée Download PDF

Info

Publication number
WO2023046169A1
WO2023046169A1 PCT/CN2022/121351 CN2022121351W WO2023046169A1 WO 2023046169 A1 WO2023046169 A1 WO 2023046169A1 CN 2022121351 W CN2022121351 W CN 2022121351W WO 2023046169 A1 WO2023046169 A1 WO 2023046169A1
Authority
WO
WIPO (PCT)
Prior art keywords
airway
concentration
concentration detection
air
alveolar gas
Prior art date
Application number
PCT/CN2022/121351
Other languages
English (en)
Chinese (zh)
Inventor
罗邦雄
杨雷
张权锋
罗景庭
黄锦波
黄秀松
杨丽华
Original Assignee
惠雨恩科技(深圳)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 惠雨恩科技(深圳)有限公司 filed Critical 惠雨恩科技(深圳)有限公司
Publication of WO2023046169A1 publication Critical patent/WO2023046169A1/fr

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/004—CO or CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0062—General constructional details of gas analysers, e.g. portable test equipment concerning the measuring method or the display, e.g. intermittent measurement or digital display

Definitions

  • the present application relates to the technical field of breath collection, in particular to an alveolar gas concentration detection device and method for separating airways.
  • Exhalation disease diagnosis technology is emerging as a new in vitro diagnostic technology that is parallel and complementary with blood test and imaging detection.
  • breath diagnosis disease technology is highly regarded by researchers and clinicians at home and abroad. Pay attention, the blue ocean of the relevant market can reach the level of 100 billion. Therefore, institutions at home and abroad are scrambling to develop breath testing instruments.
  • Existing breath testing instruments widely used clinically include breath testers for measuring red blood cell life span and Helicobacter pylori (Hp ) tester, exhaled nitric oxide (FENO) tester for detecting airway inflammation, etc. The use of these breath detection instruments is inseparable from the collection of breath.
  • Hp Helicobacter pylori
  • FENO exhaled nitric oxide
  • the gas at the front end of exhalation is also called cavity air. Because it is directly connected to the atmospheric environment, it is generally mixed with more air, and the measurement is greatly affected by the environment; while the gas at the end of exhalation is basically alveolar gas, which is the After blood circulation, the gas that is directly excreted through alveolar gas exchange and can carry a large amount of health status information can best reflect the current health status of the human body.
  • the purpose of the present invention is to provide an alveolar gas concentration detection device and method for isolated airways, which has high applicability and can meet the needs of continuous monitoring.
  • the first technical solution adopted in the present invention is: a device for detecting alveolar gas concentration that separates the airway, comprising:
  • the first airway the first airway includes an air inlet end and an air outlet end, the first airway is provided with a first electromagnetic valve, an air pump and a concentration detection module, and the air pump is arranged on the first electromagnetic valve Between the concentration detection module and the first solenoid valve, the first solenoid valve is arranged at the end of the first airway close to the inlet end, and the concentration detection module is arranged at the first airway close to the air outlet. end of end;
  • the second airway, the second airway is provided with a state monitoring module, the state monitoring module is electrically connected to the first electromagnetic valve, and the state monitoring module is used to monitor the exhalation state.
  • the air pump is arranged between the concentration detection module and the first solenoid valve, or the air pump is arranged on the side of the concentration detection module away from the first solenoid valve.
  • the alveolar gas concentration detection device for separating airways also includes:
  • a third air passage one end of the third air passage is connected between the first electromagnetic valve and the air pump, and a second electromagnetic valve is arranged on the third air passage.
  • the concentration detection module includes a carbon dioxide sensor and a carbon monoxide sensor.
  • a flow limiting module is set between the air pump and the concentration detection module.
  • the flow limiting range of the flow limiting module is between 40mL/min-60mL/min.
  • condition monitoring module includes a flow sensor or an air pressure sensor.
  • the inlet end of the first airway and one end of the second airway are integrated into an exhalation collection module.
  • the second technical solution adopted in the present invention is: a method for detecting alveolar gas concentration of separated airways, comprising:
  • the breath is inhaled into the concentration detection module, and the concentration detection module detects the target gas concentration in the breath.
  • the concentration detection module detects the target gas concentration in the breath, including:
  • the carbon dioxide sensor and the carbon monoxide sensor in the concentration detection module record the carbon dioxide concentration and the carbon monoxide concentration in the breath in real time;
  • the state monitoring module continues to monitor the exhalation state, and returns to the step of sending the first control signal to the first solenoid valve to open the first solenoid valve when the end of expiration is detected;
  • the concentration of the carbon monoxide sensor is stable, the measured concentration of carbon monoxide in the alveolar gas is obtained, and the measured concentration of carbon monoxide in the alveolar gas is the target gas concentration.
  • the device for detecting alveolar gas concentration with separated airways includes a first airway and a second airway.
  • the first air passage includes an air inlet end and an air outlet end
  • the first air passage is provided with a first electromagnetic valve, an air pump and a concentration detection module
  • the first electromagnetic valve is arranged in the first air passage
  • the concentration detection module is set at the end close to the air inlet end of the first airway;
  • the second airway is provided with a state monitoring module, and the state monitoring module is connected to the air outlet.
  • the first electromagnetic valve is electrically connected, and the state monitoring module is used to monitor the exhalation state.
  • the alveolar gas concentration detection device for separating the airway has high applicability and can meet the requirement of continuous monitoring.
  • Fig. 1 is a schematic structural diagram of an alveolar gas concentration detection device for separating airways provided in an embodiment of the present application.
  • Fig. 2 is another structural schematic diagram of the alveolar gas concentration detection device for separating the airways provided by the embodiment of the present application.
  • Fig. 3 is a comparative waveform curve of the concentration and flow rate of carbon dioxide provided by the embodiment of the present application.
  • Fig. 4 is a schematic flow chart of a method for detecting alveolar gas concentration in an isolated airway provided in an embodiment of the present application.
  • FIG. 1 is a schematic structural diagram of an alveolar gas concentration detection device for separating airways provided in an embodiment of the present application.
  • the device for detecting alveolar gas concentration with separated airways may include a first airway 10 and a second airway 20 .
  • the first air channel 10 includes an air inlet end A and an air outlet end B.
  • the first air channel 10 is provided with a first solenoid valve 11 , an air pump 12 and a concentration detection module 13 .
  • the first solenoid valve 11 is disposed at an end of the first air passage 10 close to the intake end A.
  • the concentration detection module 13 is arranged at the end of the first air passage 10 close to the air outlet B.
  • a state monitoring module 21 is arranged on the second airway 20 .
  • the state monitoring module 21 is electrically connected with the first solenoid valve 11 .
  • the intake end A of the first airway 10 and one end of the second airway 20 are integrated into an exhalation collection module.
  • an exhalation collection module Such as nasal cannula, exhalation mask, etc.
  • the air pump 12 can be disposed between the first solenoid valve 11 and the concentration detection module 13 .
  • the air pump 12 can also be arranged on the side of the concentration detection module 13 away from the first electromagnetic valve 11 .
  • the air pump 12 is electrically connected to the state detection module 21 .
  • the state monitoring module 21 can be used to monitor the exhalation state.
  • the condition monitoring module 21 may include a flow sensor or an air pressure sensor.
  • the alveolar gas concentration detection device for the separated airway can also include a third airway 30, one end of the third airway 30 is connected between the first electromagnetic valve 11 and the air pump 12, and the third airway 30 A second solenoid valve 31 is provided on it.
  • the third air channel 30 communicates with the air, and the third air channel 30 can be used to detect the gas concentration in the air.
  • the concentration detection module 13 may include a carbon dioxide sensor 131 and a carbon monoxide sensor 132 .
  • the carbon dioxide sensor 131 is disposed at the end of the first air passage 10 close to the intake end A, and the carbon monoxide sensor 132 is disposed at the end of the first air passage 10 close to the air discharge end B. It should be noted that the relative positions of the carbon dioxide sensor 131 and the carbon monoxide sensor 132 can be interchanged.
  • a flow limiting module 14 is provided between the air pump 12 and the concentration detection module 13 .
  • the gas flow limitation range of the flow limiting module 14 is between 40mL/min-60mL/min.
  • the gas flow restriction of the flow restriction module 14 is 50mL/min.
  • the flow limiting module 14 may include a flow limiting valve or a capillary.
  • the flow limiting module 14 can be used to detect the gas flow rate entering the concentration detection module 13 .
  • the state detection module 21 may also include a control unit, which may be electrically connected to various components in the alveolar gas concentration detection device for separating the airways provided in the embodiment of the present application, so as to realize the signal control.
  • a control unit which may be electrically connected to various components in the alveolar gas concentration detection device for separating the airways provided in the embodiment of the present application, so as to realize the signal control.
  • the exhalation collection module integrated with the intake end A of the first airway 10 and one end of the second airway 20 can be connected to the patient's oral cavity or nasal cavity . It should be noted that, at this moment, the first solenoid valve 11 is in a closed state. Then, the exhalation state is monitored through the state monitoring module 21 on the second airway 20 .
  • the state monitoring module 21 When the state monitoring module 21 detects the onset of end-expiration, it can send a first control signal to the first solenoid valve 11 to make the first solenoid valve 11 open. At this time, under the action of the air pump 12, breath is inhaled into the concentration detection module 13, and the carbon dioxide sensor 131 and carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and carbon monoxide concentration in real time.
  • the state monitoring module 21 When the state monitoring module 21 detects that the end of exhalation is over, it can send a second control signal to the first solenoid valve 11 to close the first solenoid valve 11 . Then, the state monitoring module 21 continues to monitor the exhalation state, and returns to the step of sending the first control signal to the first solenoid valve 11 to open the first solenoid valve 11 when the end of expiration is detected.
  • a third airway 30 may be provided in the alveolar gas concentration detection device of the separated airway.
  • one end of the third air passage 30 is connected between the first solenoid valve 11 and the air pump 12
  • the third air passage 30 is provided with a second solenoid valve 31 .
  • One end of the third air channel 30 is connected between the first electromagnetic valve 11 and the air pump 12
  • the second electromagnetic valve 31 is arranged on the third air channel 30 .
  • the second solenoid valve 31 can be opened before the end of expiration, or after the end of expiration. Under the action of the air pump 12, the air is sucked into the concentration detection module 13, the carbon dioxide sensor 131 and the carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and the carbon monoxide concentration in real time at this moment, when the carbon monoxide sensor 132 After the reading is stable, the carbon monoxide concentration C3 in the air is obtained.
  • the air pump 12 is always on.
  • the carbon dioxide concentration waveform under normal breathing conditions can be as shown in FIG. 3 . Indicating the state of respiration through the carbon dioxide concentration curve can better distinguish the various stages of exhalation.
  • the change in the CO2 concentration curve is due to the mixing of ambient air and alveolar air.
  • the carbon dioxide concentration in the inhalation section reflects the carbon dioxide concentration in the environment, and the gas in the inhalation section can be considered as ambient air.
  • the initial expiratory phase can be regarded as the proportional mixture of the ambient air in the inspiratory phase and the alveolar gas in the final expiratory phase.
  • the air in the early part of exhalation can also be considered cavity air.
  • the detection of end-tidal carbon monoxide concentration is essentially the detection of carbon monoxide concentration at the end of expiration.
  • the breathing curve can not only be reflected by the carbon dioxide concentration curve, but also can be better reflected by sensors such as flow sensor/barometric pressure sensor.
  • the advantage of the flow sensor/air pressure sensor is that the flow sensor reflects the state of breathing by detecting the breathing pressure, and can eliminate the interference caused by the change of gas composition in the air.
  • the key is that the transmission speed of the air pressure is extremely fast, and the response time of the flow sensor (air pressure sensor) is extremely short. For people with a high respiratory rate, it can more accurately reflect the changes in the breathing curve.
  • the concentration detection module 13 in the alveolar gas concentration detection device of the separated airway can be removed, and then an air bag 15 is installed on the air outlet B to collect the end-tidal gas gas. Then, the concentration of the end-tidal gas in the air bag 15 is detected by the gas sensor, so as to realize the off-line detection of the end-tidal gas.
  • FIG. 4 is a schematic flowchart of a method for detecting alveolar gas concentration in separated airways provided in an embodiment of the present application.
  • the method for detecting alveolar gas concentration of separated airways is applied to the device for detecting alveolar gas concentration of separated airways in the above embodiments.
  • the specific flow of the method for detecting the alveolar gas concentration of the separated airway can be as follows:
  • the state monitoring module 21 detects the start of end-expiration, send a first control signal to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are turned on.
  • the breath is sucked into the concentration detection module 13, and the concentration detection module 13 detects the target gas concentration in the breath.
  • the step "the concentration detection module 13 detects the concentration of the target gas in the breath” may include:
  • the carbon dioxide sensor 131 and the carbon monoxide sensor 132 in the concentration detection module 13 record the carbon dioxide concentration and the carbon monoxide concentration in the breath in real time;
  • a second control signal is sent to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are closed;
  • the state monitoring module 21 continues to monitor the exhalation state, and when it detects that the end of exhalation begins, it returns to the process of sending the first control signal to the first electromagnetic valve 11 and the air pump 12, so that the first electromagnetic valve 11 and the air pump 12 are opened. step;
  • the concentration of the carbon monoxide sensor 132 is stable, the measured concentration of carbon monoxide in the alveolar gas is obtained, and the measured concentration of carbon monoxide in the alveolar gas is the target gas concentration.
  • the device for detecting alveolar gas concentration with separated airways includes a first airway 10 and a second airway 20 .
  • the first air channel 10 includes an air inlet end A and an air outlet end B.
  • the first air channel 10 is provided with a first solenoid valve 11 , an air pump 12 and a concentration detection module 13 .
  • the first solenoid valve 11 is disposed at an end of the first air passage 10 close to the intake end A.
  • the concentration detection module 13 is arranged at the end of the first air passage 10 close to the air outlet B.
  • a state monitoring module 21 is arranged on the second airway 20 .
  • the state monitoring module 21 is electrically connected with the first electromagnetic valve 11, and the state monitoring module 21 is used for monitoring the exhalation state.
  • the alveolar gas concentration detection device for separating the airway has high applicability and can meet the requirement of continuous monitoring.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Combustion & Propulsion (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un appareil et un procédé de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée. L'appareil de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée comprend des première (10) et seconde (20) voies respiratoires. La première voie respiratoire (10) comprend une extrémité d'entrée d'air (A) et une extrémité de sortie d'air (B); la première voie respiratoire (10) est pourvue d'une première vanne électromagnétique (11), d'une pompe à air (12) et d'un module de mesure de la concentration (13); la première vanne électromagnétique (11) est disposée à l'extrémité de la première voie respiratoire (10) à proximité de l'extrémité d'entrée d'air (A); et le module de mesure de la concentration (13) est disposé à l'extrémité de la première voie respiratoire (10) à proximité de l'extrémité de sortie d'air (B). La seconde voie respiratoire (20) est pourvue d'un module de surveillance d'état (21); le module de surveillance d'état (21) est connecté électriquement à la première vanne électromagnétique (11); et le module de surveillance d'état (21) est utilisé pour surveiller un état d'expiration. L'appareil de mesure de la concentration des gaz alvéolaires pour une voie respiratoire séparée présente une grande applicabilité et peut satisfaire les exigences d'une surveillance continue.
PCT/CN2022/121351 2021-09-27 2022-09-26 Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée WO2023046169A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202111138173.6 2021-09-27
CN202111138173.6A CN113777244A (zh) 2021-09-27 2021-09-27 分离气道的肺泡气浓度检测装置及方法

Publications (1)

Publication Number Publication Date
WO2023046169A1 true WO2023046169A1 (fr) 2023-03-30

Family

ID=78853996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/121351 WO2023046169A1 (fr) 2021-09-27 2022-09-26 Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée

Country Status (2)

Country Link
CN (1) CN113777244A (fr)
WO (1) WO2023046169A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113777244A (zh) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 分离气道的肺泡气浓度检测装置及方法
CN218035914U (zh) * 2022-06-14 2022-12-13 惠雨恩科技(深圳)有限公司 一种呼气末采集装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596029A (zh) * 2009-10-22 2012-07-18 皇家飞利浦电子股份有限公司 用于测量呼出空气中气体的浓度的方法和设备
CN205157269U (zh) * 2015-12-04 2016-04-13 无锡市尚沃医疗电子股份有限公司 潮气末气体取样装置
CN105496412A (zh) * 2015-12-04 2016-04-20 无锡市尚沃医疗电子股份有限公司 一种呼气炎症监护方法和装置
US20170191984A1 (en) * 2014-09-23 2017-07-06 Shenzhen Seekya Bio-Sci & Tech Co., Ltd. Method and apparatus for measuring endogenous co concentration in alveolar air
CN109602420A (zh) * 2018-11-23 2019-04-12 深圳市美好创亿医疗科技有限公司 呼出气体检测设备及检测方法
CN113777244A (zh) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 分离气道的肺泡气浓度检测装置及方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102596029A (zh) * 2009-10-22 2012-07-18 皇家飞利浦电子股份有限公司 用于测量呼出空气中气体的浓度的方法和设备
US20170191984A1 (en) * 2014-09-23 2017-07-06 Shenzhen Seekya Bio-Sci & Tech Co., Ltd. Method and apparatus for measuring endogenous co concentration in alveolar air
CN205157269U (zh) * 2015-12-04 2016-04-13 无锡市尚沃医疗电子股份有限公司 潮气末气体取样装置
CN105496412A (zh) * 2015-12-04 2016-04-20 无锡市尚沃医疗电子股份有限公司 一种呼气炎症监护方法和装置
CN109602420A (zh) * 2018-11-23 2019-04-12 深圳市美好创亿医疗科技有限公司 呼出气体检测设备及检测方法
CN113777244A (zh) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 分离气道的肺泡气浓度检测装置及方法

Also Published As

Publication number Publication date
CN113777244A (zh) 2021-12-10

Similar Documents

Publication Publication Date Title
WO2023046169A1 (fr) Appareil et procédé de mesure de concentration des gaz alvéolaires pour voie respiratoire séparée
US20190076053A1 (en) Method and device for measuring a component in exhaled breath
US6067983A (en) Method and apparatus for controlled flow sampling from the airway
US20070123792A1 (en) System and method for determining airway obstruction
US4802492A (en) Method for determining respiratory function
US8683998B2 (en) Multipurpose cannula
US9532731B2 (en) Method and apparatus for measuring the concentration of a gas in exhaled air
JP2000506601A (ja) ヒトの呼気成分の測定のための方法および装置
Gappa et al. Comparison of nitrogen washout and plethysmographic measurements of lung volume in healthy infants
Frölund et al. Comparison between different techniques for measuring nasal patency in a group of unselected patients
Fletcher et al. Passive respiratory mechanics
CN111643086A (zh) 一种双侧鼻阻力与鼻流量测试装置及测试方法
WO2020103281A1 (fr) Appareil de détection de gaz exhalé et procédé associé
Freezer et al. Predictive value of measurements of respiratory mechanics in preterm infants with HMD
Conterato et al. Assessment of spontaneous ventilation in anesthetized children with use of a pediatric circle or a Jackson-Rees system
Paulus Capnography.
CN217237937U (zh) 分离气道的肺泡气浓度检测装置
Gerhardt et al. Measurement and monitoring of pulmonary function
WO2023046165A1 (fr) Appareil de collecte de gaz de fin d'expiration présentant des canaux d'air séparés
CN213046880U (zh) 一种新型手持式鼻阻力测试装置
CN207923877U (zh) 一种不需要控制呼气流量的呼出气一氧化氮测量装置
WO2023155612A1 (fr) Système de détection de gaz à voies respiratoires multiples et son procédé de commande
TWI766640B (zh) 血糖濃度的評估方法及檢測裝置
Waldau et al. Reliability of CO2 measurements from the airway by a pharyngeal catheter in unintubated, spontaneously breathing subjects
CN117770794A (zh) 一种鼻阻力和鼻呼气一氧化氮浓度联合测定装置及方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22872212

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE