WO2023033753A1 - Food supplement with antioxidant/ antiproliferative properties - Google Patents
Food supplement with antioxidant/ antiproliferative properties Download PDFInfo
- Publication number
- WO2023033753A1 WO2023033753A1 PCT/TR2021/050883 TR2021050883W WO2023033753A1 WO 2023033753 A1 WO2023033753 A1 WO 2023033753A1 TR 2021050883 W TR2021050883 W TR 2021050883W WO 2023033753 A1 WO2023033753 A1 WO 2023033753A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- food supplement
- supplement according
- process step
- distilled water
- artemisiaannua
- Prior art date
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 39
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 11
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 9
- 230000001028 anti-proliverative effect Effects 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 241001678559 COVID-19 virus Species 0.000 claims abstract description 16
- 240000000011 Artemisia annua Species 0.000 claims abstract description 14
- 240000007817 Olea europaea Species 0.000 claims abstract description 14
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000002725 Olea europaea Nutrition 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 10
- 238000011282 treatment Methods 0.000 claims abstract description 10
- 235000001405 Artemisia annua Nutrition 0.000 claims abstract description 9
- 241000711573 Coronaviridae Species 0.000 claims abstract description 8
- 208000025721 COVID-19 Diseases 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000008240 homogeneous mixture Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 description 7
- 230000000840 anti-viral effect Effects 0.000 description 6
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- RFWGABANNQMHMZ-UHFFFAOYSA-N 8-acetoxy-7-acetyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline Natural products CC=C1C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(C(=O)OC)=COC1OC1OC(CO)C(O)C(O)C1O RFWGABANNQMHMZ-UHFFFAOYSA-N 0.000 description 2
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 2
- 235000003097 Artemisia absinthium Nutrition 0.000 description 2
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 2
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 2
- 240000006891 Artemisia vulgaris Species 0.000 description 2
- HKVGJQVJNQRJPO-UHFFFAOYSA-N Demethyloleuropein Natural products O1C=C(C(O)=O)C(CC(=O)OCCC=2C=C(O)C(O)=CC=2)C(=CC)C1OC1OC(CO)C(O)C(O)C1O HKVGJQVJNQRJPO-UHFFFAOYSA-N 0.000 description 2
- RFWGABANNQMHMZ-HYYSZPHDSA-N Oleuropein Chemical compound O([C@@H]1OC=C([C@H](C1=CC)CC(=O)OCCC=1C=C(O)C(O)=CC=1)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RFWGABANNQMHMZ-HYYSZPHDSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000001138 artemisia absinthium Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000003293 cardioprotective effect Effects 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- RFWGABANNQMHMZ-CARRXEGNSA-N oleuropein Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)C(=CC)[C@H]1CC(=O)OCCc3ccc(O)c(O)c3 RFWGABANNQMHMZ-CARRXEGNSA-N 0.000 description 2
- 235000011576 oleuropein Nutrition 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 241000315672 SARS coronavirus Species 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 241000300544 Veronica prostrata Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003510 anti-fibrotic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 description 1
- 229960004191 artemisinin Drugs 0.000 description 1
- 229930101531 artemisinin Natural products 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000000321 herbal drug Substances 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
Definitions
- the present invention relates to a food supplement with antioxidant/antiproliferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
- Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease (COVID-19) has been associated with millions of deaths worldwide. This inflammatory, respiratory and systemic disease is highly contagious and in most cases lifethreatening.
- Document No TR2020/16536 can be shown as an example to the state of the art in the research made in the literature.
- Said document relates to an effective herbal food supplement against covid-19.
- medical and aromatic plant In said invention, medical and aromatic plant, herbal food supplement related to pharmacology-toxicology and virology, and herbal food supplement effective against Covid-19 that can be used in the pharmaceutical industry are disclosed.
- Said food supplement is obtained by extracting at least one herbal drug (root, herb, seed, fruit, etc.) with proven antiviral activities, adding sweetener and/or creating a fermentation environment by adding water.
- Document No TR2021/008034 can be shown as another example to the state of the art.
- Said document relates to an antiviral, antibacterial, anti-allergen and cardioprotective liquid food supplement
- a food supplement in the form of antiviral antibacterial, anti-allergen and cardioprotective effective syrup containing effective amounts of quercetin, resveratrol and L-ascorbic acid (vitamin C) is disclosed.
- the present invention relates to a food supplement with antioxidant/ antiproliferative properties which eliminates the abovementioned disadvantages and brings new advantages to the relevant technical field.
- the main objective of the invention is to provide a food supplement used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
- the object of the invention is to provide a food supplement obtained from Artemisia Annua plant used in the treatment of malaria infection, colloidal silver water with antibacterial, antiviral and antimicrobial effects, and OleaEuroaea (olive leaf oil extract) as binder.
- Another object of the invention is to provide a food supplement which has antioxidant/antiproliferative properties that help the body to be more resistant to the infections and external factors and support the immune system.
- the present invention relates to a food supplement with antioxidant/antiproiiferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
- the invention in its most basic form is a food supplement containing artemisiaannua, distilled water, colloidal silver water, oleaeuroaea (olive leaf oil extract) .
- the inventive food supplement is presented in spray or drop form.
- Artemisia annua is a plant extract used in traditional Chinese medicine. Artemisinin, one of the active components of the plant, has antiviral, anti-inflammatory, antiparasitic, antiallergic, antifibrotic, antiarrhythmic, immunomodulatory, antitumor and cytotoxic effects. Artemisia Annua is also known as sweat wormwood, annual wormwood, kaabe wormwood, veronica prostrata.
- Artemisia annua extracts are a good source of various phenolic compounds and are therefore considered to be a source of natural antioxidants.
- the leaves are harvested in the summer, before the plant blooms, and dried for later use.
- Distilled water is demineralized water obtained by re-liquefying the steam in a separate container.
- Colloidal silver water is a homogeneous dispersion of silver particles in pure water. Dissolved silver particles repulse each other because they have the same electrical charge. Therefore, it is completely homogeneously dispersed in the solvent. Since silver particles have the same electrical charge, they repel each other and distribute homogeneously, thus allowing them not to accumulate in the body. After they complete their tasks in the circulatory system for a certain period of time, they are disposed through the digestive system.
- Colloidal silver water is homogeneous, does not come into contact with each other and does not cause any side effects or permanent effects due to its features that it can be easily disposed of through the digestive system. Colloidal silver water has antibacterial, antiviral and antimicrobial effects.
- Oleaeuroaea (olive leaf oil extract) is used as a binder.
- the olive tree the longest- lived tree in the world, has survived for 3000 years depending on oleuropein (C25H32O13) in olive leaves, which protects from all kinds of harmful bacteria, micro-organisms and viruses and more than 20,000 other phenolic compounds.Oleuropein (OE), found in the structure of the olive leaf is the main phenolic component and is responsible for the physiological effects of the olive leaf.
- Olive oil leaf oil exhibits radical scavenging activity in food supplement.
- the process steps of the inventive production method of the food supplement is as follows; a) Boiling 25gr of artemisiaannua plant in 250ml distilled water at 50°C for 200 minutes and then letting the same rest, b) Adding 3% oleaeuroaea (olive leaf oil extract) into the mixture of artemisiaannua and distilled water, which is rested after boiling, mixing for 4 hours and obtaining a homogeneous mixture,
- 1% colloidal silver water can be added into the homogeneous mixture and mixed for half an hour.
- the inventive food supplement is preferably in the form of a spray and can also be provided in the form of drops.
- the food supplement in spray form is applied by spraying directly into the oral cavity.
- the food supplement in drop form is mixed with water and then drunk.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a food supplement with antioxidant/antiproliferative properties that is used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contains artemisia annua, distilled water, colloidal silver water and Olea Europaea (olive leaf oil extract).
Description
FOOD SUPPLEMENT WITH ANTIOXIDANT/ ANTIPROLIFERATIVE PROPERTIES
Field of the Invention
The present invention relates to a food supplement with antioxidant/antiproliferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
State of the Art
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease (COVID-19) has been associated with millions of deaths worldwide. This inflammatory, respiratory and systemic disease is highly contagious and in most cases lifethreatening.
Effective and accurate treatments are required for patients suffering from 2019 COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, in the state of the art, antiviral drugs licensed for other diseases are widely used in the treatment of COVID-19 coronavirus disease, whose clinical efficacy is questioned. For this reason, there is an urgent need for the treatment of COVID-19 and the identification of additional antivirals against SARS-CoV-2.
Document No TR2020/16536 can be shown as an example to the state of the art in the research made in the literature. Said document relates to an effective herbal food supplement against covid-19. In said invention, medical and aromatic plant, herbal food supplement related to pharmacology-toxicology and virology, and herbal food supplement effective against Covid-19 that can be used in the pharmaceutical industry are disclosed. Said food supplement is obtained by extracting at least one herbal drug (root, herb, seed, fruit, etc.) with proven antiviral activities, adding sweetener and/or creating a fermentation environment by adding water.
Document No TR2021/008034 can be shown as another example to the state of the art. Said document relates to an antiviral, antibacterial, anti-allergen and
cardioprotective liquid food supplement In said invention, a food supplement in the form of antiviral antibacterial, anti-allergen and cardioprotective effective syrup containing effective amounts of quercetin, resveratrol and L-ascorbic acid (vitamin C) is disclosed.
As a result, in order to solve the abovementioned problems and the insufficiency of the current solutions makes it necessary to make a development in the relevant technical field.
Object of the Invention
The present invention relates to a food supplement with antioxidant/ antiproliferative properties which eliminates the abovementioned disadvantages and brings new advantages to the relevant technical field.
The main objective of the invention is to provide a food supplement used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The object of the invention is to provide a food supplement obtained from Artemisia Annua plant used in the treatment of malaria infection, colloidal silver water with antibacterial, antiviral and antimicrobial effects, and OleaEuroaea (olive leaf oil extract) as binder.
Another object of the invention is to provide a food supplement which has antioxidant/antiproliferative properties that help the body to be more resistant to the infections and external factors and support the immune system.
Detailed Description of the Invention
In this detailed description, the preferred alternatives of the inventive food supplement are described only for clarifying the subject matter such that no limiting effect is created.
The present invention relates to a food supplement with antioxidant/antiproiiferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The invention in its most basic form is a food supplement containing artemisiaannua, distilled water, colloidal silver water, oleaeuroaea (olive leaf oil extract) . The inventive food supplement is presented in spray or drop form.
In Table 1 , the content and ratios of the inventive food supplement are given.
Table 1 : Food supplement content and usage rates
Artemisia annua is a plant extract used in traditional Chinese medicine. Artemisinin, one of the active components of the plant, has antiviral, anti-inflammatory, antiparasitic, antiallergic, antifibrotic, antiarrhythmic, immunomodulatory, antitumor and cytotoxic effects. Artemisia Annua is also known as sweat wormwood, annual wormwood, kaabe wormwood, veronica prostrata.
Artemisia annua extracts are a good source of various phenolic compounds and are therefore considered to be a source of natural antioxidants. The leaves are harvested in the summer, before the plant blooms, and dried for later use.
Since Artmesiaannua is known to be a natural source of antioxidants, it is beneficial for all people exposed to free radicals.
Distilled water is demineralized water obtained by re-liquefying the steam in a separate container.
Colloidal silver water is a homogeneous dispersion of silver particles in pure water. Dissolved silver particles repulse each other because they have the same electrical charge. Therefore, it is completely homogeneously dispersed in the solvent. Since silver particles have the same electrical charge, they repel each other and distribute homogeneously, thus allowing them not to accumulate in the body. After they complete their tasks in the circulatory system for a certain period of time, they are disposed through the digestive system. Colloidal silver water is homogeneous, does not come into contact with each other and does not cause any side effects or permanent effects due to its features that it can be easily disposed of through the digestive system. Colloidal silver water has antibacterial, antiviral and antimicrobial effects.
Oleaeuroaea (olive leaf oil extract) is used as a binder.The olive tree, the longest- lived tree in the world, has survived for 3000 years depending on oleuropein (C25H32O13) in olive leaves, which protects from all kinds of harmful bacteria, micro-organisms and viruses and more than 20,000 other phenolic compounds.Oleuropein (OE), found in the structure of the olive leaf is the main phenolic component and is responsible for the physiological effects of the olive leaf. Olive oil leaf oil exhibits radical scavenging activity in food supplement.
The process steps of the inventive production method of the food supplement is as follows; a) Boiling 25gr of artemisiaannua plant in 250ml distilled water at 50°C for 200 minutes and then letting the same rest, b) Adding 3% oleaeuroaea (olive leaf oil extract) into the mixture of artemisiaannua and distilled water, which is rested after boiling, mixing for 4 hours and obtaining a homogeneous mixture,
C) Packaging of the resulting liquid mixture.
After the process step (b) mentioned in an alternative embodiment of the invention, 1% colloidal silver water can be added into the homogeneous mixture and mixed for half an hour.
The inventive food supplement is preferably in the form of a spray and can also be provided in the form of drops.
The food supplement in spray form is applied by spraying directly into the oral cavity.
The food supplement in drop form is mixed with water and then drunk.
Claims
1. A food supplement with antioxidant/antiproliferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), characterized in that;
- It contains artemisiaannua, distilled water and oleaeuroaea (olive leaf oil extract).
2. A food supplement according to claim 1, characterized in that; it contains 25-150grartemisiaannua by weight.
3. A food supplement according to claim 1, characterized in that; it contains 250-1000ml distilled water by weight.
4. A food supplement according to claim 1, characterized in that; it contains %3-30 oleaeuroaea (olive leaf oil extract) by weight.
5. A food supplement according to claim 1, characterized in that; it contains colloidal silver water.
6. A food supplement according to claim 5, characterized in that; colloidal silver wateris in a ratio of 1-20%.
7. A method for producing a food supplement with antioxidant/antiproliferative properties used in the treatment of COVID-19 coronavirus disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), characterized in that;it comprises the following process steps; a) Boiling artemisiaannua plant in distilled water and then letting it rest, b) Adding oleaeuroaea (olive leaf oil extract) into the mixture of artemisiaannua and distilled water, which is rested after boiling, mixing the same and obtaining a homogeneous mixture,
C) Packaging of the resulting liquid mixture.
8. A food supplement according to claim 6, characterized in that; artemisiaannua plant is boiled in distilled water at 50°C for 200 minutes in said process step (a).
5 9. A food supplement according to claim 6, characterized in that; artemisiaannua plant is 25gr in said process step (a).
10. A food supplement according to claim 6, characterized in that; the distilled water is 250 ml in said process step (a).
10
11. A food supplement according to claim 6, characterized in that; oleaeuroaea (olive leaf oil extract) is in a ratio of 3% in said process step (b).
12. A food supplement according to claim 6, characterized in that; the mixture is
15 mixed for 4 hours in said process step (b).
13. A food supplement according to claim 6, characterized in that; it comprises the process step of adding colloidal silver water into the homogenous mixture and mixing the same for half an hour after said process step (b).
20
14. A food supplement according to claim 13, characterized in that; colloidal silver water is in a ratio of 1%.
15. A food supplement according to claim 1 or claim 6, characterized in that; it
25 is in spray or drop form.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2021/013784 | 2021-09-02 | ||
| TR2021/013784A TR2021013784A2 (en) | 2021-09-02 | 2021-09-02 | FOOD SUPPLEMENT WITH ANTIOXIDANT/ANTIPROLIFERATIVE PROPERTIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023033753A1 true WO2023033753A1 (en) | 2023-03-09 |
Family
ID=83995966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/TR2021/050883 WO2023033753A1 (en) | 2021-09-02 | 2021-09-04 | Food supplement with antioxidant/ antiproliferative properties |
Country Status (2)
| Country | Link |
|---|---|
| TR (1) | TR2021013784A2 (en) |
| WO (1) | WO2023033753A1 (en) |
-
2021
- 2021-09-02 TR TR2021/013784A patent/TR2021013784A2/en unknown
- 2021-09-04 WO PCT/TR2021/050883 patent/WO2023033753A1/en unknown
Non-Patent Citations (2)
| Title |
|---|
| IGNATOV IGNAT: "Antiviral Effects of Water Catholyte, Oxidal with Methylene Blue and Colloidal Silver. Possible Mechanism of Influence over Coronavirus SARSr-CoV and SARSr-CoV-2 with Disease COVID-19", JOURNAL OF HEALTH, MEDICINE AND NURSING, vol. 73, 30 April 2020 (2020-04-30), pages 96 - 101, XP093044634, ISSN: 2422-8419, DOI: 10.7176/JHMN/73-11 * |
| PATEL BHOOMIKA; SHARMA SUPRIYA; NAIR NISHA; MAJEED JASEELA; GOYAL RAMESH K.; DHOBI MAHAVEER: "Therapeutic opportunities of edible antiviral plants for COVID-19", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 476, no. 6, 15 February 2021 (2021-02-15), pages 2345 - 2364, XP037451857, ISSN: 0300-8177, DOI: 10.1007/s11010-021-04084-7 * |
Also Published As
| Publication number | Publication date |
|---|---|
| TR2021013784A2 (en) | 2021-09-21 |
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