WO2023027638A3 - Polyfluorophore nanoreporters for fluorogenic imaging and early diagnosis - Google Patents

Polyfluorophore nanoreporters for fluorogenic imaging and early diagnosis Download PDF

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Publication number
WO2023027638A3
WO2023027638A3 PCT/SG2022/050602 SG2022050602W WO2023027638A3 WO 2023027638 A3 WO2023027638 A3 WO 2023027638A3 SG 2022050602 W SG2022050602 W SG 2022050602W WO 2023027638 A3 WO2023027638 A3 WO 2023027638A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
polyfluorophore
nanoreporters
fluorogenic
imaging
Prior art date
Application number
PCT/SG2022/050602
Other languages
French (fr)
Other versions
WO2023027638A2 (en
WO2023027638A9 (en
Inventor
Kanyi Pu
Jiaguo Huang
Original Assignee
Nanyang Technological University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanyang Technological University filed Critical Nanyang Technological University
Priority to CN202280057428.2A priority Critical patent/CN117858731A/en
Publication of WO2023027638A2 publication Critical patent/WO2023027638A2/en
Publication of WO2023027638A3 publication Critical patent/WO2023027638A3/en
Publication of WO2023027638A9 publication Critical patent/WO2023027638A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Disclosed herein is a polymeric nanoreporter compound according to formula I, or a pharmaceutically acceptable salt or solvate thereof, and its uses. Also disclosed herein is a method of detecting a pathological condition in a subject, the method comprising the steps of (a) administering a polymeric nanoreporter compound according to formula I, or a pharmaceutically acceptable salt or solvate thereof, that targets the selected pathological condition to a subject; and (b) detecting any fluorescence in one or both of urine from the subject and an organ or a tissue in the subject that is targeted by the polymeric nanoreporter compound according to formula I, wherein the presence of the pathological condition in the subject is indicated by fluorescence in the urine, the tissue or organ, or both the urine and the tissue or organ.
PCT/SG2022/050602 2021-08-23 2022-08-23 Polyfluorophore nanoreporters for fluorogenic imaging and early diagnosis WO2023027638A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202280057428.2A CN117858731A (en) 2021-08-23 2022-08-23 Multi-fluorophore nanoreporters for fluorescence imaging and early diagnosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10202109190P 2021-08-23
SG10202109190P 2021-08-23

Publications (3)

Publication Number Publication Date
WO2023027638A2 WO2023027638A2 (en) 2023-03-02
WO2023027638A3 true WO2023027638A3 (en) 2023-04-13
WO2023027638A9 WO2023027638A9 (en) 2023-05-11

Family

ID=85323513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2022/050602 WO2023027638A2 (en) 2021-08-23 2022-08-23 Polyfluorophore nanoreporters for fluorogenic imaging and early diagnosis

Country Status (2)

Country Link
CN (1) CN117858731A (en)
WO (1) WO2023027638A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110213121A1 (en) * 2008-08-29 2011-09-01 Ick-Chan Kwon Nanoparticle sensor for measuring protease activity and method for manufacturing the same
WO2018064383A1 (en) * 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methods and compositions for noninvasive detection of organ transplant rejection
WO2020081635A2 (en) * 2018-10-16 2020-04-23 Massachusetts Institute Of Technology Renal clearable nanocatalysts for disease monitoring

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110213121A1 (en) * 2008-08-29 2011-09-01 Ick-Chan Kwon Nanoparticle sensor for measuring protease activity and method for manufacturing the same
WO2018064383A1 (en) * 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methods and compositions for noninvasive detection of organ transplant rejection
WO2020081635A2 (en) * 2018-10-16 2020-04-23 Massachusetts Institute Of Technology Renal clearable nanocatalysts for disease monitoring

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUANG, J. ET AL.: "Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 59, no. 29, 13 July 2020 (2020-07-13), pages 11717 - 11731, XP072101418, [retrieved on 20230301], DOI: 10.1002/ANIE.202001783 *
HUANG, J. ET AL.: "Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection", NATURE MATERIALS, vol. 21, no. 5, 14 April 2022 (2022-04-14), pages 598 - 607, XP037815790, [retrieved on 20230301], DOI: 10.1038/S41563-022-01224-2 *

Also Published As

Publication number Publication date
CN117858731A (en) 2024-04-09
WO2023027638A2 (en) 2023-03-02
WO2023027638A9 (en) 2023-05-11

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