WO2022270369A1 - Nutritional composition - Google Patents

Nutritional composition Download PDF

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Publication number
WO2022270369A1
WO2022270369A1 PCT/JP2022/023893 JP2022023893W WO2022270369A1 WO 2022270369 A1 WO2022270369 A1 WO 2022270369A1 JP 2022023893 W JP2022023893 W JP 2022023893W WO 2022270369 A1 WO2022270369 A1 WO 2022270369A1
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nutritional composition
content
mass
kcal
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PCT/JP2022/023893
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French (fr)
Japanese (ja)
Inventor
英利 小久保
英智 三浦
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森永乳業株式会社
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Priority to JP2023530369A priority Critical patent/JPWO2022270369A1/ja
Publication of WO2022270369A1 publication Critical patent/WO2022270369A1/en

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates

Definitions

  • the present invention relates to nutritional compositions.
  • a basic method for suppressing elevation of blood sugar level is to limit the content of carbohydrates in nutritional compositions.
  • sugar content is limited, it is necessary to maintain the calorie of the nutritional composition, so it is necessary to increase the lipid content from the viewpoint of compensating for this.
  • palatinose is also known to use as a carbohydrate in nutritional compositions from the viewpoint of suppressing blood sugar level elevation.
  • Patent Document 1 discloses a nutritional composition containing a nitrogen source, a lipid and a carbohydrate, wherein the nitrogen source contains free isoleucine and/or free leucine, the lipid contains a medium-chain fatty acid triglyceride, and the sugar
  • a nutritional composition for suppressing hyperglycemia characterized by containing palatinose (isomaltulose) and/or trehalose is described.
  • This nutritional composition is excellent in nutritional balance even when ingested for a long period of time, can suppress hyperglycemia after administration, and can reduce the amount of insulin administered.
  • an object of the present invention is to provide a nutritional composition having good emulsification stability even when the lipid content is a predetermined amount or more and the emulsifier content is a predetermined amount or less.
  • the present inventors found that, in a nutritional composition having a lipid content of a predetermined amount or more, by setting the ratio of medium-chain fatty acids in the total fatty acid composition of the lipid to a certain level or more, the content of the emulsifier is reduced to at least emulsification stability. It has been found that a good nutritional composition is obtained. In addition, in the course of research and development to solve the above problems, the present inventors found that increasing the content of palatinose (isomaltulose) in the nutritional composition lowers the emulsion stability.
  • the present inventors have found that even in nutritional compositions containing palatinose (isomaltulose), the ratio of medium-chain fatty acids in the total fatty acids contained in the lipids contained in the nutritional composition is set to a certain level or more, so that emulsifiers are contained. It has been found that at least the amount results in a nutritional composition with good emulsion stability. That is, the present invention is as follows.
  • the present invention for solving the above problems is a nutritional composition
  • a nutritional composition comprising a lipid, a carbohydrate, and an emulsifier
  • the lipid content in the nutritional composition is 3.5 g/100 kcal or more
  • the content of the emulsifier in the nutritional composition is 0.60 g/100 kcal or less
  • the lipid is a nutritional composition containing 20% by mass or more of medium-chain fatty acids in the total constituent fatty acids.
  • the nutritional composition having the above characteristics has good emulsification stability even when the lipid content is equal to or greater than the predetermined amount and the emulsifier content is equal to or less than the predetermined amount.
  • the carbohydrate includes palatinose (isomaltulose). Containing palatinose (isomaltulose) as carbohydrate makes it difficult for the blood sugar level to rise.
  • the content of palatinose (isomaltulose) in the nutritional composition is 2 g/100 kcal or more.
  • a sweet taste is felt and the blood sugar level is less likely to rise.
  • the ratio of the emulsifier content to the lipid content is 6.5% by mass or less.
  • the carbohydrate content is 15 g/100 kcal or less.
  • the calorie is 0.6 kcal/mL or more. By setting the calorie within the above range, the calorie can be efficiently ingested.
  • the nutritional composition further contains protein.
  • the nutritional composition is for suppressing elevation of blood sugar level.
  • the present invention also provides a method for improving the emulsion stability of a nutritional composition, A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates; an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
  • the lipid content in the nutritional composition is 3.5 g/100 kcal or more,
  • the lipid contains medium-chain fatty acids in a proportion of 20% by mass or more in the total constituent fatty acids, It is also a method for improving emulsion stability.
  • the present invention A method for producing a nutritional composition, comprising: A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates; an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
  • the lipid content in the nutritional composition is 3.5 g/100 kcal or more,
  • the lipid contains medium-chain fatty acids in a proportion of 20% by mass or more in the total constituent fatty acids, It is also a method of making a nutritional composition.
  • the present invention it is possible to provide a nutritional composition with good emulsification stability even when the lipid content is a predetermined amount or more and the emulsifier content is a predetermined amount or less.
  • the nutritional composition according to the present invention contains lipids, carbohydrates, and emulsifiers. Ingredients contained in the nutritional composition according to the present invention are described below.
  • lipids according to the present invention for example, MCT, fish oil and vegetable oil can be preferably used.
  • vegetable oils soybean oil, rapeseed oil, rice oil, corn oil, coconut oil, olive oil, sunflower oil, palm oil, flax oil, perilla oil, and safflower oil can be preferably used.
  • the lipid content per 100 kcal of the nutritional composition according to the present invention is 3.5 g or more, preferably 3.8 g or more, 4.1 g or more, more preferably 4.2 g or more, 4.3 g or more, 4 .4 g or more.
  • the lipid content per 100 kcal of the nutritional composition according to the present invention is preferably 10.0 g or less, 9.0 g or less, 8.0 g or less, 7.0 g or less, 6.2 g or less, more preferably 6 0 g or less, 5.5 g or less, 5.0 g or less, more preferably 4.5 g or less, 4.4 g or less.
  • the emulsion stability can be further improved.
  • the lipid content per 100 mL of the nutritional composition according to the present invention is preferably 2.1 g or more, 2.5 g or more, 3.0 g or more, 3.5 g or more, more preferably 4.0 g or more, 4 .5g or more, 5.0g or more, 5.5g or more, more preferably 6.0g or more, 6.1g or more, 6.2g or more, 6.3g or more, 6.4g or more, 6.5g or more, 6.6g 6.7 g or more, 6.8 g or more, 6.9 g or more, and 7.0 g or more.
  • a nutritional composition with high energy concentration and good energy intake efficiency can be obtained.
  • the lipid content per 100 mL of the nutritional composition according to the present invention is preferably 20.0 g or less, 19.0 g or less, 18.0 g or less, 17.0 g or less, 16.0 g or less, 15.0 g or less. 7 .1 g or less.
  • the emulsion stability can be further improved.
  • the lipid contains medium-chain fatty acids among its constituent fatty acids.
  • medium-chain fatty acids refer to fatty acids having 8 to 10 carbon atoms.
  • Examples of medium-chain fatty acids include caprylic acid and capric acid.
  • the proportion of medium-chain fatty acids in the total fatty acids in the lipid is 20% by mass or more, preferably 21% by mass or more, 22% by mass or more, 23% by mass or more, 24% by mass or more, and 25% by mass.
  • the ratio of medium-chain fatty acids in the total constituent fatty acids of the lipid is preferably 90% by mass or less, 89% by mass or less, 88% by mass or less, 87% by mass or less, 86% by mass or less, and 85% by mass or less.
  • MCT refers to oils and fats containing substantially 100% by mass of medium-chain fatty acids among constituent fatty acids.
  • the lipid may further contain an n-3 fatty acid among its constituent fatty acids.
  • n-3 fatty acids include docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and ⁇ -linolenic acid (ALA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). is particularly preferred.
  • the ratio of docosahexaenoic acid (DHA) in the total fatty acids constituting the lipid is preferably 0.1% by mass or more, 0.2% by mass or more, or 0.3% by mass or more as the lower limit, and the upper limit is 0. 0.6% by mass or less, 0.5% by mass or less, and 0.4% by mass or less. Also, any consistent combination of these may be used.
  • the ratio of eicosapentaenoic acid (EPA) in the total fatty acids constituting the lipid is preferably 0.2% by mass or more, 0.5% by mass or more, or 0.7% by mass or more as the lower limit, and the upper limit is They are 1.3 mass % or less, 1.0 mass % or less, and 0.8 mass % or less. Also, any consistent combination of these may be used.
  • the ratio of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in the total fatty acids constituting the lipids of the nutritional composition produced is within the above range.
  • DHA docosahexaenoic acid
  • EPA eicosapentaenoic acid
  • the fish oil fish (sardines, mackerel, bonito, tuna, Alaska pollock, etc.) as raw materials are boiled and the oil is separated from the broth and the oil can be appropriately refined.
  • the nutritional composition according to the present invention contains carbohydrates, and the content per 100 kcal is preferably 15 g or less, 14 g or less, 13 g or less, 12 g or less, 11 g or less, or 10 g or less.
  • the carbohydrate content per 100 mL of the nutritional composition according to the present invention is preferably 30 g or less, 29 g or less, 28 g or less, 27 g or less, 26 g or less, more preferably 25 g or less, 24 g or less, 23 g or less, or 22 g. 21 g or less, more preferably 20 g or less, 19 g or less, 18 g or less, and particularly preferably 17 g or less.
  • carbohydrates refer to components other than dietary fiber among carbohydrates.
  • disaccharides As carbohydrates, disaccharides, oligosaccharides, starch hydrolysates, and fructose can be preferably used. Palatinose (isomaltulose), sucrose, maltose, cellobiose, lactose, isomaltose and trehalose can be particularly preferably used as disaccharides.
  • oligosaccharides As oligosaccharides, lactulose, raffinose, galacto-oligosaccharides, fructo-oligosaccharides, xylooligosaccharides, and milk oligosaccharides can be particularly preferably used.
  • starch decomposition product dextrin, maltodextrin, malto-oligosaccharide, powdered candy, and highly branched dextrin can be particularly preferably used.
  • the lower limit of the content of palatinose (isomaltulose) per 100 kcal of the nutritional composition according to the present invention is preferably 2.0 g or more and 2.1 g or more, more preferably 2.2 g or more and 2.3 g or more. , 2.4 g or more, 2.5 g or more, 2.6 g or more, 2.7 g or more, 2.8 g or more, 2.9 g or more, 3.0 g or more, 3.1 g or more, 3.2 g or more, 3.3 g or more , 3.4 g or more, 3.5 g or more, 3.6 g or more, 3.7 g or more, more preferably 3.8 g or more.
  • the upper limit of the content of palatinose (isomaltulose) per 100 kcal of the nutritional composition according to the present invention is preferably 10.0 g or less, 9.5 g or less, 9.0 g or less, 8.5 g or less, 8.0 g or less, 7.5 g or less, more preferably 7.0 g or less, 6.5 g or less, 6.0 g or less, 5.5 g or less, more preferably 5.0 g or less, 4.5 g or less, 4.0 g or less , 3.9 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the content of palatinose (isomaltulose) per 100 mL of the nutritional composition according to the present invention is preferably 1.2 g or more, 1.5 g or more, 2.0 g or more, 2.5 g or more, 3.0 g or more, more preferably 3.5 g or more, 4.0 g or more, 4.5 g or more, 5.0 g or more, 5.5 g or more, still more preferably 6.0 g or more, 6.1 g or more.
  • the upper limit of the content of palatinose (isomaltulose) per 100 mL of the nutritional composition according to the present invention is preferably 20.0 g or less, 19.0 g or less, 18.0 g or less, 17.0 g or less, 16.0 g or less, more preferably 15.0 g or less, 14.0 g or less, 13.0 g or less, 12.0 g or less, 11.0 g or less, 10.0 g or less, 9.0 g or less, 8.0 g or less, more preferably is 7.9 g or less, 7.8 g or less, 7.7 g or less, 7.6 g or less, 7.5 g or less, 7.4 g or less, 7.3 g or less, 7.2 g or less, 7.1 g or less, 7.0 g or less , 6.9 g or less, 6.8 g or less, 6.7 g or less, 6.6 g or less, 6.5 g or less, 6.4 g or less, 6.3 g or less, 6.2
  • the lower limit of the proportion of palatinose (isomaltulose) in carbohydrates is preferably 20% by mass or more, 25% by mass or more, more preferably 30% by mass or more, 31% by mass or more, 32% by mass or more, and 33% by mass. % or more, 34% by mass or more, more preferably 35% by mass or more and 36% by mass or more, and the upper limit is preferably 90% by mass or less, 89% by mass or less, 88% by mass or less, 87% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, 65% by mass or less, 60% by mass or less, 59% by mass or less, 58% by mass or less. Also, any consistent combination of these may be used.
  • sweetness can be felt and the blood sugar level is less likely to rise.
  • the content of palatinose (isomaltulose) may be as described above, or the total content of disaccharides may be added to the above-mentioned palatinose ( isomaltulose) content may be applied.
  • the lower limit of the oligosaccharide content per 100 kcal of the nutritional composition according to the present invention is preferably 0.1 g or more and 0.2 g or more, and the upper limit is 2.0 g or less and 1.0 g. Below, it is 0.8 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the oligosaccharide content per 100 mL of the nutritional composition according to the present invention is preferably 0.06 g or more, 0.1 g or more, 0.2 g or more, or 0.5 g or more, and the upper limit is is 3.0 g or less, 2.0 g or less, 1.5 g or less, or 1.0 g or less. Also, any consistent combination of these may be used. Intestinal environment can be improved by including oligosaccharides.
  • the lower limit of the content of the starch decomposition product per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more, 2.0 g or more, or 3.0 g or more, and the upper limit is preferably 12.0 g or less, 11.0 g or less, 10.0 g or less, and 9.0 g or less. Also, any consistent combination of these may be used.
  • the content of the starch decomposition product per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, and the upper limit is is preferably 24 g or less, 22 g or less, 20 g or less, 19 g or less, 18 g or less, 17 g or less, 16 g or less, 15 g or less, and 14 g or less. Also, any consistent combination of these may be used.
  • the nutritional composition according to the present invention contains an emulsifier and its content is 0.60 g/100 kcal or less.
  • the lower limit of the emulsifier content per 100 kcal is preferably 0.01 g or more, 0.02 g or more, 0.03 g or more, 0.04 g or more, 0.05 g or more, 0.06 g or more, 0.07 g or more, 0.08 g or more, 0.09 g or more, 0.10 g, 0.11 g or more, 0.12 g or more, 0.13 g or more, 0.14 g or more, 0.15 g or more.
  • the upper limit of the emulsifier content per 100 kcal is preferably 0.60 g or less, 0.59 g or less, 0.58 g or less, 0.57 g or less, 0.56 g or less, 0.55 g or less, 0.54 g.
  • the lower limit of the content of the emulsifier per 100 mL of the nutritional composition according to the present invention is preferably 0.006 g or more, more preferably 0.01 g or more, still more preferably 0.10 g or more, and particularly preferably 0.20 g or more.
  • the upper limit of the content of the emulsifier per 100 mL of the nutritional composition according to the present invention is preferably 0.50 g or less, more preferably 0.30 g or less, even more preferably 0.20 g or less, and particularly preferably 0.2 g or less. 15 g or less. Also, any consistent combination of these may be used.
  • the ratio of the emulsifier content to the lipid content is preferably 1.0% by mass or more, more preferably 1.5% by mass or more, 2.0% by mass or more, and 3.0% by mass as a lower limit. Above, more preferably 3.5% by mass or more, 3.6% by mass or more, 3.7% by mass or more, 3.8% by mass or more, and 3.9% by mass or more.
  • the upper limit of the ratio of the emulsifier content to the lipid content is preferably 6.5% by mass or less, 6.0% by mass or less, 5.5% by mass or less, 5.0% by mass or less, or more. It is preferably 4.5% by mass or less, 4.4% by mass or less, 4.3% by mass or less, and 4.2% by mass or less. Also, any consistent combination of these may be used.
  • the nutritional composition according to the present invention has good emulsion stability even when the content of the emulsifier is within the above range.
  • the emulsifier is not particularly limited as long as it can be used as food, and examples thereof include lecithin, organic acid monoglyceride, glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, and sucrose fatty acid ester.
  • lecithin and organic acid monoglyceride can be preferably used. It is particularly preferred to contain both lecithin and organic acid monoglyceride, preferably in a mass ratio of 1:9 to 9:1, more preferably 3:7 to 7:3, even more preferably 4:6 to 6:4. is.
  • the nutritional composition according to the present invention preferably contains dietary fiber. It is preferable to use water-soluble dietary fiber as dietary fiber. Moreover, it is preferable to use a dietary fiber having an effect of suppressing an increase in blood sugar level. Either high-viscosity or low-viscosity dietary fiber can be used.
  • Water-soluble dietary fibers known to have the effect of suppressing elevation of blood sugar include inulin, indigestible dextrin, polydextrose, guar gum decomposition product, pectin, glucomannan, ⁇ -glucan, alginate, guar gum, and agar. A suitable example can be given. It is also possible to blend one or more of these. In particular, one or more selected from indigestible dextrin and inulin can be preferably used.
  • the lower limit of the dietary fiber content per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more and 2.0 g or more, and the upper limit is preferably 5.0 g or less and 4.0 g. It is below. Also, any consistent combination of these may be used.
  • the lower limit of the content of dietary fiber per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 1.5 g or more, 2.0 g or more, and the upper limit is is preferably 10.0 g or less, 9.0 g or less, 8.0 g or less, 7.0 g or less, 6.0 g or less, or 5.0 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the inulin content per 100 kcal of the nutritional composition according to the present invention is preferably 0.1 g or more and 0.5 g or more, and the upper limit is preferably 2.5 g or less and 2.0 g or less. , 1.5 g or less, and 1.0 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the content of inulin per 100 mL of the nutritional composition according to the present invention is preferably 0.06 g or more, 0.1 g or more, 0.2 g or more, 0.3 g or more, 0.4 g or more, It is 0.5 g or more and 1.0 g or more, and the upper limit is preferably 4.0 g or less, 3.5 g or less, 3.0 g or less, 2.5 g or less, 2.0 g or less, and 1.5 g or less. Also, any consistent combination of these may be used.
  • the content of indigestible dextrin per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more and 2.0 g or more as a lower limit, and preferably 4.0 g or less as an upper limit. , 3.0 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the content of the indigestible dextrin per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, The upper limit is preferably 8.0 g or less, 6.0 g or less, or 4.0 g or less. Also, any consistent combination of these may be used.
  • Intestinal environment can be improved by including dietary fiber.
  • by including dietary fiber having a blood sugar level suppressing effect the blood sugar level suppressing effect of the nutritional composition can be further enhanced.
  • the nutritional composition according to the invention preferably contains protein.
  • the type of protein is not particularly limited as long as it is used for foods, such as milk protein, egg protein, animal protein such as collagen, vegetable protein such as soybean protein, rice protein, and wheat protein.
  • Milk proteins are particularly preferably used in the present invention.
  • casein sodium caseinate, calcium caseinate, potassium caseinate, micellar casein (MCC), milk protein concentrate (MPC), milk protein isolate (MPI), milk protein hydrolyzate (MPH), concentrate Whey protein (WPC), whey protein isolate (WPI) and the like can be used.
  • the lower limit of the protein content per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more, 2.0 g or more, or 3.0 g or more, and the upper limit is preferably 6.0 g or less. , 5.0 g or less, and 4.0 g or less. Also, any consistent combination of these may be used.
  • the lower limit of the protein content per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, 4.0 g or more, It is 5.0 g or more, and the upper limit is preferably 12.0 g or less, 10.0 g or less, or 7.0 g or less. Also, any consistent combination of these may be used.
  • ⁇ Other ingredients Arbitrary components can be appropriately used in the nutritional composition according to the present invention within a range that does not impair the effects of the present technology.
  • Optional ingredients include, for example, vitamins, minerals, carnitine, milk/dairy products, stabilizers, thickeners, pH adjusters, flavoring agents, fragrances, pigments, bifidobacterium powder, and lactic acid bacteria powder.
  • the calorie content of the nutritional composition according to the present invention is preferably 0.6 kcal/mL or more, 1.0 kcal/mL or more, 1.3 kcal/mL or more, 1.4 kcal/mL or more, 1.5 kcal/mL or more. 6 kcal/mL or more, 1.7 kcal/mL or more, 1.8 kcal/mL or more, 1.9 kcal/mL or more, 2.0 kcal/mL or more.
  • the calorific value of the nutritional composition according to the present invention is preferably calorific value mainly derived from lipids, carbohydrates, and proteins.
  • the lipid energy ratio, carbohydrate energy ratio, and protein energy ratio refer to the ratio of the calorie derived from lipids, carbohydrates, and proteins to the calorie in the nutritional composition.
  • the lower limit of the lipid energy ratio of the nutritional composition according to the present invention is preferably 30% or more, 35% or more, and 40% or more, and the upper limit is preferably 60% or less, 55% or less, and 50% or less. is. Also, any consistent combination of these may be used.
  • the lower limit is preferably 30% or more, 35% or more and 40% or more
  • the upper limit is preferably 60% or less, 55% or less and 50% or less. is. Also, any consistent combination of these may be used.
  • the ratio of energy derived from carbohydrates is called the carbohydrate energy ratio.
  • the carbohydrate energy ratio of the nutritional composition according to the present invention has a lower limit of preferably 25% or more, 30% or more and 35% or more, and an upper limit of preferably 55% or less, 50% or less and 45%. It is below. Also, any consistent combination of these may be used.
  • the lower limit of the protein energy ratio of the nutritional composition according to the present invention is preferably 5% or more and 10% or more, and the upper limit is preferably 25% or less and 20% or less. Also, any consistent combination of these may be used.
  • the nutritional composition according to the present invention is preferably for suppressing elevation of blood sugar level.
  • “suppression of blood sugar level rise” and “suppression of blood sugar level rise” refer to the action of suppressing a rapid rise in blood sugar level, the action of lowering or lowering blood sugar level, and the action of slowing the absorption of sugar, especially after a meal. It refers to the action to improve hyperglycemia and the action to improve hyperglycemia.
  • the nutritional composition of the present invention can be used for suppressing elevation of blood sugar level.
  • the nutritional composition according to the present invention may be in liquid or semi-solid form, but liquid form is particularly preferred.
  • the upper limit of the viscosity at 20° C. of the nutritional composition according to the present invention is preferably 100000 mPa ⁇ s or less, 10000 mPa ⁇ s or less, 1000 mPa ⁇ s or less, 100 mPa ⁇ s or less, 50 mPa ⁇ s or less, or 30 mPa ⁇ s or less. be.
  • the lower limit of the viscosity at 20° C. of the nutritional composition according to the present invention is 0.1 mPa ⁇ s or more, more preferably 1 mPa ⁇ s or more.
  • the nutritional composition according to the present invention can be provided as an oral nutritional composition, as well as a nutritional composition for nasal administration and a nutritional composition for gastrostomy tube administration.
  • the nutritional composition of the present invention can be produced by preparing an oil phase containing lipids and an aqueous phase containing carbohydrates, and emulsifying them by adding an emulsifier.
  • the aqueous phase preferably contains proteins and carbohydrates.
  • the preferred aspects described above can be applied.
  • the mass ratio of the oil phase to the water phase is preferably 1:6 to 1:60.
  • the present invention also provides a method for improving the emulsion stability of a nutritional composition, comprising: a preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates; and an emulsification step of adding and mixing an emulsifier of 60 g/100 kcal or less, wherein the content of the lipid in the nutritional composition is 3.5 g/100 kcal or more, and the lipid contains all its constituent fatty acids. It is also a method for improving emulsification stability by including medium-chain fatty acids in a proportion of 20% by mass or more.
  • the aqueous phase preferably contains proteins and carbohydrates.
  • the method for improving emulsion stability improves emulsion stability, particularly in nutritional compositions containing palatinose (isomaltulose). As other preferred aspects, the preferred aspects described above can be applied.
  • Test Example 1 Emulsion stability test (effect of lipid content)>
  • Test Example 1 in order to examine the effect of lipid content on emulsion stability, two samples with different lipid contents were prepared and the emulsion stability was examined.
  • a nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, respectively, and emulsifying them by adding an emulsifier.
  • an emulsifier lecithin and organic acid monoglyceride were used at a weight ratio of 1:1.
  • the control example and comparative example 1-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
  • lipid energy ratio, lipid content, ratio of medium-chain fatty acids in the total constituent fatty acids (medium-chain fatty acid ratio), carbohydrate energy ratio, carbohydrate content, and palatinose of the lipids of the control example and Comparative Example 1-1 (Isomaltulose) content and emulsifier content are as shown in Table 1.
  • ⁇ Weight of centrifuge tube residue Transfer the liquid contents to another container after centrifugation, measure the weight of the centrifuge tube, subtract the previously measured weight of the centrifuge tube alone, and calculate the weight of the centrifuge tube residue. was measured.
  • the weight of the residue in the centrifuge tube is the total weight of the fat component adhering to the upper part of the centrifuge tube and the sediment remaining in the lower part of the centrifuge tube.
  • Test Example 2 Emulsion stability test (influence of palatinose (isomaltulose) content)>
  • Test Example 2 in order to examine the effect of the palatinose (isomaltulose) content on emulsion stability, samples with different palatinose (isomaltulose) contents were prepared and the emulsion stability was examined.
  • a nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier.
  • an emulsifier lecithin and organic acid monoglyceride were used at a weight ratio of 1:1.
  • Control and Comparative Examples 2-1 to 2-6 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
  • the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, carbohydrate content, palatinose (iso Maltulose) content and emulsifier content are as shown in Table 3.
  • the same test as in Test Example 1 was performed on the samples shown in Table 3.
  • the fat deposit relative area was calculated with the area of the control example set at 1.000.
  • Table 4 shows the results.
  • FIG. 3 shows a photograph taken during the evaluation of the relative fat deposit area.
  • a graph of the results of fat deposit relative area is shown in FIG.
  • palatinose in both evaluations, there was a tendency that the higher the content of palatinose (isomaltulose), the worse the emulsion stability. From the above, it was shown that palatinose (isomaltulose) dose-dependently deteriorates emulsification stability in nutritional compositions containing a certain amount or more of lipids.
  • ⁇ Test Example 3 Emulsion stability test (influence of medium-chain fatty acid ratio)> In Test Examples 3 to 9, in order to examine the influence of medium-chain fatty acid ratios on emulsion stability, samples with different medium-chain fatty acid ratios were prepared and their emulsion stability was examined.
  • a nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1.
  • the control, comparative example 3-1, and example 3-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
  • the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, carbohydrate content, and palatinose of the lipids in the control example, Comparative Example 3-1, and Example 3-1 (Isomaltulose) content and emulsifier content are as shown in Table 5.
  • the same test as in Test Example 1 was performed on the samples shown in Table 5.
  • the fat deposit relative area was calculated with the area of the control example set at 1.000. Table 6 shows the results.
  • FIG. 5 shows a photograph taken during the evaluation of the relative fat deposit area.
  • a graph of the results of fat deposit relative area is shown in FIG.
  • Example 3-1 which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 3-1. From the above, it was shown that in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 0 g/100 kcal, increasing the ratio of medium-chain fatty acids improves emulsion stability.
  • Example 4-1 which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 4-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 2.29 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
  • Example 5-1 which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 5-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
  • Example 6-1 which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 6-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 4.58 g/100 kcal, the emulsification stability is improved by increasing the ratio of medium-chain fatty acids.
  • Example 7-1 which has a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 7-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 6.11 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
  • ⁇ Test Example 8 Emulsion stability test (influence of medium-chain fatty acid ratio)>
  • the samples listed in Table 11 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field.
  • the fat deposit relative area was calculated by setting the area of Comparative Example 8-1 to 1.000.
  • Table 11 shows the results.
  • FIG. 15 shows photographs taken during the evaluation of the relative fat deposit area.
  • a graph of the results of fat deposit relative area is shown in FIG.
  • Example 8-1 which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 8-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 6.87 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
  • Example 9-1 which had a higher medium-chain fatty acid ratio, showed better emulsion stability than Comparative Example 9-1. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 9.16 g/100 kcal, the emulsification stability is improved by increasing the medium-chain fatty acid ratio.
  • ⁇ Test Example 10 Emulsion stability test (comparison when the emulsifier content is further reduced)>
  • Test Example 10 the effects of the palatinose (isomaltulose) content and medium-chain fatty acid ratio on the emulsion stability were investigated when the emulsifier content was further reduced. Except for the ratio of medium-chain fatty acids in the total constituent fatty acids, the content of palatinose (isomaltulose), and the content of emulsifier, the samples shown in Table 13 were tested under the same conditions as in Comparative Example 3-1, as in Test Example 1. A similar test was performed. The fat deposit relative area was calculated by setting the area of Comparative Example 10-1 to 1.000. The results are shown in Table 13. In addition, FIG. 19 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
  • Example 10-1 showed better emulsification stability than Comparative Example 10-1. From the above, in a nutritional composition with a high fat content, even if the emulsifier content is reduced, the combination of increasing the ratio of medium-chain fatty acids in the fatty acids constituting the lipid and containing palatinose (isomaltulose) , it was shown that a liquid nutritional composition with good emulsification stability can be obtained even if it is high in fat.
  • Test Example 11 Blood sugar level measurement>
  • a nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, respectively, and emulsifying them by adding an emulsifier.
  • an emulsifier lecithin and organic acid monoglyceride were used at a weight ratio of 1:1.
  • the control and Example 11-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
  • the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in the total constituent fatty acids, carbohydrate energy ratio, carbohydrate content, and palatinose (isomaltulose) content of the lipid in the control example and Example 11-1 The amount and emulsifier content are as shown in Table 14.
  • the subjects were nine adult men and women. From the start to the end of the test, a Freestyle Libre Pro sensor (manufactured by Abbott Japan LLC) was worn on the upper arm, and the blood sugar level was measured every 15 minutes. After resting for 1 hour on an empty stomach in the morning, they ingested 125 mL of either test food, and then rested for an additional 2 hours. After an interval of 3 days or more, the other test food was similarly tested.
  • the amount of increase in blood glucose level after subtracting the blood glucose level in the morning fasting and the area under the curve were evaluated.
  • the amount of blood glucose increase and the average value of the area under the curve at each time point were calculated, and the significant difference between the control example and Example 11-1 was tested by the paired t-test, and a risk rate of 5% or less was considered significant.
  • FIG. 21 shows the amount of increase in blood sugar based on the blood sugar level at the time of ingestion.
  • the increase in blood sugar 45 minutes after eating was 39 ⁇ 14 mg/dL in the control example, whereas it was 27 ⁇ 14 mg/dL in Example 11-1, which was significantly suppressed.
  • iAUC ⁇ Area under the blood glucose increase curve
  • the nutritional composition according to the present invention can suppress an increase in blood sugar level.
  • Example 12-1 contains palatinose (isomaltulose), highly branched dextrin, milk protein, indigestible dextrin, MCT, vegetable oil, starch hydrolyzate, lactulose, inulin, refined fish oil, yeast extract, dry yeast, carnitine, lactic acid bacteria (pasteurized), sodium caseinate, pH adjuster, emulsifier, potassium chloride, flavor, caramel coloring.
  • the amount of the emulsifier was 0.175 g/100 kcal, and the weight ratio of lecithin and organic acid monoglyceride was 1:1.
  • Example 12-1 was sterilized at an ultra-high temperature, 125 mL each was aseptically filled into paper packs, and stored at room temperature for 6 months. When the degree of fat floatation of Example 12-1 that had been stored still for 6 months was visually confirmed, no fat floatation that would cause problems in use was observed, and the product was in good condition.
  • Example 13-1 and 13-2 which have higher medium-chain fatty acid ratios, showed better emulsification stability than Comparative Example 13-1.
  • Example 13-2 which has a higher medium-chain fatty acid ratio, good results in emulsion stability were obtained. From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
  • Emulsion stability test (influence of medium-chain fatty acid ratio)>
  • samples with different ratios of medium-chain fatty acids were prepared under conditions of high lipid content, and the emulsion stability was examined.
  • a nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier.
  • an emulsifier lecithin and organic acid monoglyceride were used at a weight ratio of 1:1.
  • Comparative Example 14-1, Example 14-1, and Example 14-2 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal. Further, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, and carbohydrate content of the lipids of Comparative Example 14-1, Example 14-1, and Example 14-2 , palatinose (isomaltulose) content, and emulsifier content are as shown in Table 17. The same test as in Test Example 1 was performed on the samples shown in Table 17. The fat deposit relative area was calculated by setting the area of Comparative Example 14-1 to 1.000. The results are shown in Table 18. In addition, FIG. 25 shows a photograph of evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
  • Example 14-1 and 14-2 which have higher medium-chain fatty acid ratios, showed better emulsification stability than Comparative Example 14-1.
  • Example 14-2 which has a higher ratio of medium-chain fatty acids, good emulsion stability was obtained. From the above, even in a nutritional composition with a particularly high fat content of 6.11 g/kcal and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves emulsion stability. It has been shown.
  • a stable nutritional composition can be provided.

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Abstract

The present invention addresses the problem of providing a nutritional composition that has high calories and that has excellent emulsification stability even when the contained amount of an emulsifier is less. This nutritional composition contains lipids, carbohydrates, and an emulsifier. The contained amount of the lipids in the nutritional composition is 3.5 g/100kcal or more. The contained amount of the emulsifier in the nutritional composition is 0.60 g/100kcal or less. In the lipids, the proportion of medium chain fatty acids in the total constitutional fatty acids is 20 mass% or more.

Description

栄養組成物nutritional composition
 本発明は、栄養組成物に関する。 The present invention relates to nutritional compositions.
 糖尿病患者や、血糖値の高い高齢者の栄養補給のために、血糖値上昇が抑制された栄養組成物が求められている。血糖値上昇を抑制するための基本的手法は、栄養組成物における糖質の含有量を制限することである。ここで、糖質の含有量を制限した場合であっても、栄養組成物の熱量を維持することが必要となるため、これを補う観点から脂質の含有量を増加させることが必要となる。
 また、血糖値上昇を抑制する観点から、栄養組成物の糖質としてパラチノース(イソマルツロース)を使用することが知られている。
There is a demand for a nutritional composition that suppresses an increase in blood sugar level for nutritional supplementation of diabetic patients and elderly people with high blood sugar levels. A basic method for suppressing elevation of blood sugar level is to limit the content of carbohydrates in nutritional compositions. Here, even if the sugar content is limited, it is necessary to maintain the calorie of the nutritional composition, so it is necessary to increase the lipid content from the viewpoint of compensating for this.
It is also known to use palatinose (isomaltulose) as a carbohydrate in nutritional compositions from the viewpoint of suppressing blood sugar level elevation.
 例えば、特許文献1には、窒素源、脂質及び糖質を含有する栄養組成物であって、窒素源に遊離イソロイシン及び/又は遊離ロイシンを含有し、脂質に中鎖脂肪酸トリグリセリドを含有し、糖質にパラチノース(イソマルツロース)及び/又はトレハロースを含有することを特徴とする高血糖抑制用栄養組成物が記載されている。この栄養組成物は、長期間摂取した場合でも栄養バランスに優れ、かつ投与後の高血糖を抑制でき、インスリン投与量を軽減できる。 For example, Patent Document 1 discloses a nutritional composition containing a nitrogen source, a lipid and a carbohydrate, wherein the nitrogen source contains free isoleucine and/or free leucine, the lipid contains a medium-chain fatty acid triglyceride, and the sugar A nutritional composition for suppressing hyperglycemia characterized by containing palatinose (isomaltulose) and/or trehalose is described. This nutritional composition is excellent in nutritional balance even when ingested for a long period of time, can suppress hyperglycemia after administration, and can reduce the amount of insulin administered.
再表2009/096579号公報Retable 2009/096579
 従来、栄養組成物における脂質の含有量を増加させようとすると、その乳化安定性が課題となる。
 乳化安定性を高める方法としては、乳化剤の含有量を増加させる方法がある。しかしながら、乳化剤には特有の好ましくない風味があり、その含有量は極力少ない方が好ましい。
 そこで、本発明は、脂質の含有量が所定量以上であり、乳化剤の含有量が所定量以下であっても、乳化安定性が良好な栄養組成物を提供することを課題とする。
Conventionally, attempts to increase the lipid content in nutritional compositions pose a problem of their emulsion stability.
As a method for enhancing the emulsion stability, there is a method of increasing the content of the emulsifier. However, emulsifiers have a characteristic undesirable flavor, and the content thereof should preferably be as low as possible.
Accordingly, an object of the present invention is to provide a nutritional composition having good emulsification stability even when the lipid content is a predetermined amount or more and the emulsifier content is a predetermined amount or less.
 本発明者らは、脂質の含有量が所定量以上の栄養組成物において、脂質の全構成脂肪酸中の中鎖脂肪酸の割合を一定以上とすることで、乳化剤の含有量が少なくとも乳化安定性が良好な栄養組成物が得られることを見出した。
 また、本発明者らは、上記課題を解決するための研究開発過程で、栄養組成物中のパラチノース(イソマルツロース)の含有量を増加させると、乳化安定性が低下することを見出した。本発明者らは、パラチノース(イソマルツロース)を含有する栄養組成物においても、栄養組成物に含まれる脂質の全構成脂肪酸中の中鎖脂肪酸の割合を一定以上とすることで、乳化剤の含有量が少なくとも乳化安定性が良好な栄養組成物が得られることを見出した。
 すなわち、本発明は、以下の通りである。
The present inventors found that, in a nutritional composition having a lipid content of a predetermined amount or more, by setting the ratio of medium-chain fatty acids in the total fatty acid composition of the lipid to a certain level or more, the content of the emulsifier is reduced to at least emulsification stability. It has been found that a good nutritional composition is obtained.
In addition, in the course of research and development to solve the above problems, the present inventors found that increasing the content of palatinose (isomaltulose) in the nutritional composition lowers the emulsion stability. The present inventors have found that even in nutritional compositions containing palatinose (isomaltulose), the ratio of medium-chain fatty acids in the total fatty acids contained in the lipids contained in the nutritional composition is set to a certain level or more, so that emulsifiers are contained. It has been found that at least the amount results in a nutritional composition with good emulsion stability.
That is, the present invention is as follows.
 前記課題を解決する本発明は、脂質と、糖質と、乳化剤とを含む栄養組成物であって、
 前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
 前記栄養組成物中の前記乳化剤の含有量は、0.60g/100kcal以下であり、
 前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、栄養組成物である。
 上記特徴を有する栄養組成物は、脂質の含有量が所定量以上であり、乳化剤の含有量が所定量以下であっても、乳化安定性が良好である。
The present invention for solving the above problems is a nutritional composition comprising a lipid, a carbohydrate, and an emulsifier,
The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
The content of the emulsifier in the nutritional composition is 0.60 g/100 kcal or less,
The lipid is a nutritional composition containing 20% by mass or more of medium-chain fatty acids in the total constituent fatty acids.
The nutritional composition having the above characteristics has good emulsification stability even when the lipid content is equal to or greater than the predetermined amount and the emulsifier content is equal to or less than the predetermined amount.
 また、本発明の好ましい形態では、前記糖質は、パラチノース(イソマルツロース)を含む。
 糖質としてパラチノース(イソマルツロース)を含むことによって、血糖値が上昇しにくくなる。
Moreover, in a preferred embodiment of the present invention, the carbohydrate includes palatinose (isomaltulose).
Containing palatinose (isomaltulose) as carbohydrate makes it difficult for the blood sugar level to rise.
 また、本発明の好ましい形態では、前記栄養組成物中のパラチノース(イソマルツロース)の含有量は、2g/100kcal以上である。
 パラチノース(イソマルツロース)を2g/100kcal以上含有することによって、甘みが感じられ、かつ血糖値が上昇しにくくなる。
Also, in a preferred embodiment of the present invention, the content of palatinose (isomaltulose) in the nutritional composition is 2 g/100 kcal or more.
By containing 2 g/100 kcal or more of palatinose (isomaltulose), a sweet taste is felt and the blood sugar level is less likely to rise.
 また、本発明の好ましい形態では、脂質の含有量に対する乳化剤の含有量の比率が6.5質量%以下である。
 乳化剤の含有量の比率を一定以下とすることによって、乳化剤特有の好ましくない風味を低減することができる。
Further, in a preferred embodiment of the present invention, the ratio of the emulsifier content to the lipid content is 6.5% by mass or less.
By setting the content ratio of the emulsifier to a certain value or less, it is possible to reduce the undesirable flavor peculiar to the emulsifier.
 また、本発明の好ましい形態では、糖質の含有量が、15g/100kcal以下である。
 糖質の含有量を前記範囲とすることによって、血糖値が上昇しにくくなる。
Moreover, in a preferred embodiment of the present invention, the carbohydrate content is 15 g/100 kcal or less.
By setting the sugar content within the above range, the blood sugar level is less likely to rise.
 また、本発明の好ましい形態では、熱量が0.6kcal/mL以上である。
 熱量を前記範囲とすることによって、熱量を効率よく摂取することができる。
Further, in a preferred form of the present invention, the calorie is 0.6 kcal/mL or more.
By setting the calorie within the above range, the calorie can be efficiently ingested.
 また、本発明の好ましい形態では、栄養組成物は、さらに、たんぱく質を含む。 In addition, in a preferred form of the present invention, the nutritional composition further contains protein.
 また、本発明の好ましい形態では、栄養組成物は、血糖値上昇抑制用である。 Also, in a preferred form of the present invention, the nutritional composition is for suppressing elevation of blood sugar level.
 また、本発明は、栄養組成物の乳化安定性向上方法であって、
 脂質を含む油相と、糖質を含む水相とを調製する調製工程と、
 前記油相及び前記水相を、0.60g/100kcal以下の乳化剤を添加して混合する乳化工程とを含み、
 前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
 前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、
 乳化安定性向上方法でもある。
The present invention also provides a method for improving the emulsion stability of a nutritional composition,
A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates;
an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
The lipid contains medium-chain fatty acids in a proportion of 20% by mass or more in the total constituent fatty acids,
It is also a method for improving emulsion stability.
 また、本発明は、
 栄養組成物の製造方法であって、
 脂質を含む油相と、糖質を含む水相とを調製する調製工程と、
 前記油相及び前記水相を、0.60g/100kcal以下の乳化剤を添加して混合する乳化工程とを含み、
 前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
 前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、
 栄養組成物の製造方法でもある。
In addition, the present invention
A method for producing a nutritional composition, comprising:
A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates;
an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
The lipid contains medium-chain fatty acids in a proportion of 20% by mass or more in the total constituent fatty acids,
It is also a method of making a nutritional composition.
 本発明によれば、脂質の含有量が所定量以上であり、乳化剤の含有量が所定量以下であっても、乳化安定性が良好な栄養組成物を提供することができる。本発明の好ましい形態では、血糖値上昇が抑制され、一定以上の熱量を有する乳化安定性が良好な栄養組成物を提供することができる。 According to the present invention, it is possible to provide a nutritional composition with good emulsification stability even when the lipid content is a predetermined amount or more and the emulsifier content is a predetermined amount or less. In a preferred embodiment of the present invention, it is possible to provide a nutritional composition that suppresses an increase in blood sugar level, has a certain amount of calories or more, and has good emulsification stability.
試験例1における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 1 試験例1における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 1 試験例2における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 2 試験例2における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 2 試験例3における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 3 試験例3における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 3 試験例4における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 4 試験例4における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 4 試験例5における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 5 試験例5における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 5 試験例6における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 6 試験例6における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 6 試験例7における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 7 試験例7における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 7 試験例8における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 8 試験例8における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 8 試験例9における脂肪付着の相対面積の評価の写真Photograph of evaluation of relative area of fat deposit in Test Example 9 試験例9における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 9 試験例10における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 10 試験例10における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 10 試験例11における血糖値上昇量のグラフGraph of increase in blood glucose level in Test Example 11 試験例11における血糖値上昇曲線下面積のグラフGraph of area under the blood glucose level increase curve in Test Example 11 試験例13における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 13 試験例13における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 13 試験例14における脂肪付着相対面積の評価の写真Photograph of evaluation of fat adhesion relative area in Test Example 14 試験例14における脂肪付着相対面積のグラフGraph of fat adhesion relative area in Test Example 14
 以下、本発明の実施の形態について説明し、本発明の理解に供する。なお、以下の実施の形態は、本発明を具体化した一例であって、特許請求の範囲に記載された範囲内において適宜変更が可能である。 Embodiments of the present invention will be described below for understanding of the present invention. It should be noted that the following embodiment is an example that embodies the present invention, and can be appropriately modified within the scope described in the claims.
 本発明に係る栄養組成物は、脂質と、糖質と、乳化剤とを含む。以下、本発明に係る栄養組成物に含まれる成分について説明する。 The nutritional composition according to the present invention contains lipids, carbohydrates, and emulsifiers. Ingredients contained in the nutritional composition according to the present invention are described below.
[成分]
<脂質>
 本発明に係る脂質として、例えばMCT、魚油、植物油を好ましく用いることができる。また、植物油として、大豆油、菜種油、米油、コーン油、やし油、オリーブ油、ひまわり油、パーム油、フラックス油、エゴマ油、サフラワー油を好ましく用いることができる。
[component]
<Lipid>
As lipids according to the present invention, for example, MCT, fish oil and vegetable oil can be preferably used. As vegetable oils, soybean oil, rapeseed oil, rice oil, corn oil, coconut oil, olive oil, sunflower oil, palm oil, flax oil, perilla oil, and safflower oil can be preferably used.
 本発明に係る栄養組成物の100kcalあたりの脂質の含有量は3.5g以上であって、好ましくは3.8g以上、4.1g以上、より好ましくは4.2g以上、4.3g以上、4.4g以上である。
 100kcalあたりの脂質の含有量を上記範囲内とすることで、脂質由来のエネルギーを多く含む栄養組成物とすることができる。
 本発明に係る栄養組成物の100kcalあたりの脂質の含有量は、好ましくは10.0g以下、9.0g以下、8.0g以下、7.0g以下、6.2g以下であり、より好ましくは6.0g以下、5.5g以下、5.0g以下、さらに好ましくは4.5g以下、4.4g以下である。
 100kcalあたりの脂質の含有量を上記上限以下とすることによって、乳化安定性をより改善することができる。
The lipid content per 100 kcal of the nutritional composition according to the present invention is 3.5 g or more, preferably 3.8 g or more, 4.1 g or more, more preferably 4.2 g or more, 4.3 g or more, 4 .4 g or more.
By setting the lipid content per 100 kcal within the above range, a nutritional composition containing a large amount of lipid-derived energy can be obtained.
The lipid content per 100 kcal of the nutritional composition according to the present invention is preferably 10.0 g or less, 9.0 g or less, 8.0 g or less, 7.0 g or less, 6.2 g or less, more preferably 6 0 g or less, 5.5 g or less, 5.0 g or less, more preferably 4.5 g or less, 4.4 g or less.
By setting the lipid content per 100 kcal to the above upper limit or less, the emulsion stability can be further improved.
 また、本発明に係る栄養組成物の100mLあたりの脂質の含有量は、好ましくは2.1g以上、2.5g以上、3.0g以上、3.5g以上、より好ましくは4.0g以上、4.5g以上、5.0g以上、5.5g以上、さらに好ましくは6.0g以上、6.1g以上、6.2g以上、6.3g以上、6.4g以上、6.5g以上、6.6g以上、6.7g以上、6.8g以上、6.9g以上、7.0g以上である。
 栄養組成物の100mLあたりの脂質の含有量を上記範囲内とすることで、エネルギーの濃度が高く、エネルギーの摂取効率の良い栄養組成物とすることができる。
 また、本発明に係る栄養組成物の100mLあたりの脂質の含有量は、好ましくは20.0g以下、19.0g以下、18.0g以下、17.0g以下、16.0g以下、15.0g以下、14.0g以下、13.0g以下、12.0g以下、11.0g以下、より好ましくは10.0g以下、9.5g以下、9.0g以下、8.0g以下、7.5g以下、7.1g以下である。
 栄養組成物の100mLあたりの脂質の含有量を上記範囲内とすることで、乳化安定性をより改善することができる。
In addition, the lipid content per 100 mL of the nutritional composition according to the present invention is preferably 2.1 g or more, 2.5 g or more, 3.0 g or more, 3.5 g or more, more preferably 4.0 g or more, 4 .5g or more, 5.0g or more, 5.5g or more, more preferably 6.0g or more, 6.1g or more, 6.2g or more, 6.3g or more, 6.4g or more, 6.5g or more, 6.6g 6.7 g or more, 6.8 g or more, 6.9 g or more, and 7.0 g or more.
By setting the lipid content per 100 mL of the nutritional composition within the above range, a nutritional composition with high energy concentration and good energy intake efficiency can be obtained.
In addition, the lipid content per 100 mL of the nutritional composition according to the present invention is preferably 20.0 g or less, 19.0 g or less, 18.0 g or less, 17.0 g or less, 16.0 g or less, 15.0 g or less. 7 .1 g or less.
By setting the lipid content per 100 mL of the nutritional composition within the above range, the emulsion stability can be further improved.
 また、前記脂質は、その構成脂肪酸中に、中鎖脂肪酸を含む。
 なお、本明細書中において、中鎖脂肪酸とは、炭素数8~10の脂肪酸を指す。中鎖脂肪酸の例として、カプリル酸、カプリン酸が挙げられる。
In addition, the lipid contains medium-chain fatty acids among its constituent fatty acids.
In this specification, medium-chain fatty acids refer to fatty acids having 8 to 10 carbon atoms. Examples of medium-chain fatty acids include caprylic acid and capric acid.
 また、前記脂質は、その全構成脂肪酸中の中鎖脂肪酸の割合が20質量%以上であり、好ましくは21質量%以上、22質量%以上、23質量%以上、24質量%以上、25質量%以上、26質量%以上、27質量%以上、28質量%以上、29質量%以上、30質量%以上、31質量%以上、32質量%以上、33質量%以上、34質量%以上、35質量%以上、36質量%以上、37質量%以上、38質量%以上、39質量%以上、40質量%以上、より好ましくは41質量%以上、42質量%以上、43質量%以上、44質量%以上、45質量%以上、46質量%以上である。
 また、前記脂質は、その全構成脂肪酸中の中鎖脂肪酸の割合が、好ましくは90質量%以下、89質量%以下、88質量%以下、87質量%以下、86質量%以下、85質量%以下、84質量%以下、83質量%以下、82質量%以下、81質量%以下、80質量%以下、79質量%以下、78質量%以下、77質量%以下、76質量%以下、75質量%以下、74質量%以下、73質量%以下、72質量%以下、71質量%以下、70質量%以下、69質量%以下、68質量%以下、67質量%以下、66質量%以下、65質量%以下、64質量%以下、63質量%以下、62質量%以下、61質量%以下、60質量%以下、59質量%以下、58質量%以下、57質量%以下、56質量%以下、55質量%以下、54質量%以下、53質量%以下、52質量%以下、51質量%以下、より好ましくは50質量%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
In addition, the proportion of medium-chain fatty acids in the total fatty acids in the lipid is 20% by mass or more, preferably 21% by mass or more, 22% by mass or more, 23% by mass or more, 24% by mass or more, and 25% by mass. 26% by mass or more, 27% by mass or more, 28% by mass or more, 29% by mass or more, 30% by mass or more, 31% by mass or more, 32% by mass or more, 33% by mass or more, 34% by mass or more, 35% by mass 36% by mass or more, 37% by mass or more, 38% by mass or more, 39% by mass or more, 40% by mass or more, more preferably 41% by mass or more, 42% by mass or more, 43% by mass or more, 44% by mass or more, It is 45 mass % or more and 46 mass % or more.
In addition, the ratio of medium-chain fatty acids in the total constituent fatty acids of the lipid is preferably 90% by mass or less, 89% by mass or less, 88% by mass or less, 87% by mass or less, 86% by mass or less, and 85% by mass or less. , 84% by mass or less, 83% by mass or less, 82% by mass or less, 81% by mass or less, 80% by mass or less, 79% by mass or less, 78% by mass or less, 77% by mass or less, 76% by mass or less, 75% by mass or less , 74% by mass or less, 73% by mass or less, 72% by mass or less, 71% by mass or less, 70% by mass or less, 69% by mass or less, 68% by mass or less, 67% by mass or less, 66% by mass or less, 65% by mass or less , 64% by mass or less, 63% by mass or less, 62% by mass or less, 61% by mass or less, 60% by mass or less, 59% by mass or less, 58% by mass or less, 57% by mass or less, 56% by mass or less, 55% by mass or less , 54% by mass or less, 53% by mass or less, 52% by mass or less, 51% by mass or less, and more preferably 50% by mass or less. Also, any consistent combination of these may be used.
 脂質原料としてMCTを7質量%以上90質量%以下含むことによって、製造される栄養組成物に含まれる脂質の構成脂肪酸中の中鎖脂肪酸の割合を上記範囲内とすることができる。なお、本明細書中においてMCTとは、構成脂肪酸中に中鎖脂肪酸を実質的に100質量%含む油脂のことをいう。 By containing 7% by mass or more and 90% by mass or less of MCT as a lipid raw material, the proportion of medium-chain fatty acids in the constituent fatty acids of the lipid contained in the produced nutritional composition can be within the above range. In the present specification, MCT refers to oils and fats containing substantially 100% by mass of medium-chain fatty acids among constituent fatty acids.
 また、前記脂質は、その構成脂肪酸中に、さらにn-3系脂肪酸を含むことができる。
 n-3系脂肪酸の例として、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)、α-リノレン酸(ALA)などが挙げられるが、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)を含むことが特に好ましい。
In addition, the lipid may further contain an n-3 fatty acid among its constituent fatty acids.
Examples of n-3 fatty acids include docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α-linolenic acid (ALA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). is particularly preferred.
 脂質の全構成脂肪酸中のドコサヘキサエン酸(DHA)の割合は、下限としては、好ましくは0.1質量%以上、0.2質量%以上、0.3質量%以上であり、上限としては、0.6質量%以下、0.5質量%以下、0.4質量%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The ratio of docosahexaenoic acid (DHA) in the total fatty acids constituting the lipid is preferably 0.1% by mass or more, 0.2% by mass or more, or 0.3% by mass or more as the lower limit, and the upper limit is 0. 0.6% by mass or less, 0.5% by mass or less, and 0.4% by mass or less. Also, any consistent combination of these may be used.
 脂質の全構成脂肪酸中のエイコサペンタエン酸(EPA)の割合は、下限としては、好ましくは0.2質量%以上、0.5質量%以上、0.7質量%以上であり、上限としては、1.3質量%以下、1.0質量%以下、0.8質量%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The ratio of eicosapentaenoic acid (EPA) in the total fatty acids constituting the lipid is preferably 0.2% by mass or more, 0.5% by mass or more, or 0.7% by mass or more as the lower limit, and the upper limit is They are 1.3 mass % or less, 1.0 mass % or less, and 0.8 mass % or less. Also, any consistent combination of these may be used.
 脂質原料として、魚油を1質量%以上6質量%以下含むことで、製造される栄養組成物の脂質の全構成脂肪酸中のドコサヘキサエン酸(DHA)、及びエイコサペンタエン酸(EPA)の割合を上記範囲内とすることができる。
 魚油として、原料となる魚(イワシ、サバ、カツオ、マグロ、スケソウダラ等)を煮熟し、煮汁の中から油を分離して適宜精製したものを用いることができる。
By containing 1% by mass or more and 6% by mass or less of fish oil as a lipid raw material, the ratio of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in the total fatty acids constituting the lipids of the nutritional composition produced is within the above range. can be within
As the fish oil, fish (sardines, mackerel, bonito, tuna, Alaska pollock, etc.) as raw materials are boiled and the oil is separated from the broth and the oil can be appropriately refined.
 また、脂質原料として、植物油を10質量%以上93質量%以下含むことが好ましい。 In addition, it is preferable to contain 10% by mass or more and 93% by mass or less of vegetable oil as a lipid raw material.
<糖質>
 本発明に係る栄養組成物は、糖質を含み、その100kcalあたりの含有量は、好ましくは15g以下、14g以下、13g以下、12g以下、11g以下、10g以下である。
<sugar>
The nutritional composition according to the present invention contains carbohydrates, and the content per 100 kcal is preferably 15 g or less, 14 g or less, 13 g or less, 12 g or less, 11 g or less, or 10 g or less.
 また、本発明に係る栄養組成物の100mLあたりの糖質の含有量は、好ましくは30g以下、29g以下、28g以下、27g以下、26g以下、より好ましくは25g以下、24g以下、23g以下、22g以下、21g以下、さらに好ましくは20g以下、19g以下、18g以下、特に好ましくは17g以下である。
 ここで、糖質とは、炭水化物のうち、食物繊維以外の成分をいう。
In addition, the carbohydrate content per 100 mL of the nutritional composition according to the present invention is preferably 30 g or less, 29 g or less, 28 g or less, 27 g or less, 26 g or less, more preferably 25 g or less, 24 g or less, 23 g or less, or 22 g. 21 g or less, more preferably 20 g or less, 19 g or less, 18 g or less, and particularly preferably 17 g or less.
Here, carbohydrates refer to components other than dietary fiber among carbohydrates.
 糖質として、二糖類、オリゴ糖、デンプン分解物、果糖を好ましく用いることができる。
 二糖類として、パラチノース(イソマルツロース)、ショ糖、麦芽糖、セロビオース、ラクトース、イソマルトース、トレハロースを特に好ましく用いることができる。また、オリゴ糖として、ラクチュロース、ラフィノース、ガラクトオリゴ糖、フラクトオリゴ糖、キシロオリゴ糖、乳果オリゴ糖を特に好ましく用いることができる。また、デンプン分解物として、デキストリン、マルトデキストリン、マルトオリゴ糖、粉飴、高分岐デキストリンを特に好ましく用いることができる。
As carbohydrates, disaccharides, oligosaccharides, starch hydrolysates, and fructose can be preferably used.
Palatinose (isomaltulose), sucrose, maltose, cellobiose, lactose, isomaltose and trehalose can be particularly preferably used as disaccharides. As oligosaccharides, lactulose, raffinose, galacto-oligosaccharides, fructo-oligosaccharides, xylooligosaccharides, and milk oligosaccharides can be particularly preferably used. As the starch decomposition product, dextrin, maltodextrin, malto-oligosaccharide, powdered candy, and highly branched dextrin can be particularly preferably used.
 本発明に係る栄養組成物の100kcalあたりのパラチノース(イソマルツロース)の含有量は、下限としては、好ましくは2.0g以上、2.1g以上、より好ましくは2.2g以上、2.3g以上、2.4g以上、2.5g以上、2.6g以上、2.7g以上、2.8g以上、2.9g以上、3.0g以上、3.1g以上、3.2g以上、3.3g以上、3.4g以上、3.5g以上、3.6g以上、3.7g以上、さらに好ましくは3.8g以上である。
 また、本発明に係る栄養組成物の100kcalあたりのパラチノース(イソマルツロース)の含有量は、上限としては、好ましくは10.0g以下、9.5g以下、9.0g以下、8.5g以下、8.0g以下、7.5g以下、より好ましくは7.0g以下、6.5g以下、6.0g以下、5.5g以下、さらに好ましくは5.0g以下、4.5g以下、4.0g以下、3.9g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
The lower limit of the content of palatinose (isomaltulose) per 100 kcal of the nutritional composition according to the present invention is preferably 2.0 g or more and 2.1 g or more, more preferably 2.2 g or more and 2.3 g or more. , 2.4 g or more, 2.5 g or more, 2.6 g or more, 2.7 g or more, 2.8 g or more, 2.9 g or more, 3.0 g or more, 3.1 g or more, 3.2 g or more, 3.3 g or more , 3.4 g or more, 3.5 g or more, 3.6 g or more, 3.7 g or more, more preferably 3.8 g or more.
The upper limit of the content of palatinose (isomaltulose) per 100 kcal of the nutritional composition according to the present invention is preferably 10.0 g or less, 9.5 g or less, 9.0 g or less, 8.5 g or less, 8.0 g or less, 7.5 g or less, more preferably 7.0 g or less, 6.5 g or less, 6.0 g or less, 5.5 g or less, more preferably 5.0 g or less, 4.5 g or less, 4.0 g or less , 3.9 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりのパラチノース(イソマルツロース)の含有量は、下限としては、好ましくは1.2g以上、1.5g以上、2.0g以上、2.5g以上、3.0g以上、より好ましくは3.5g以上、4.0g以上、4.5g以上、5.0g以上、5.5g以上、さらに好ましくは6.0g以上、6.1g以上である。
 また、本発明に係る栄養組成物の100mLあたりのパラチノース(イソマルツロース)の含有量は、上限としては、好ましくは20.0g以下、19.0g以下、18.0g以下、17.0g以下、16.0g以下、より好ましくは15.0g以下、14.0g以下、13.0g以下、12.0g以下、11.0g以下、10.0g以下、9.0g以下、8.0g以下、さらに好ましくは7.9g以下、7.8g以下、7.7g以下、7.6g以下、7.5g以下、7.4g以下、7.3g以下、7.2g以下、7.1g以下、7.0g以下、6.9g以下、6.8g以下、6.7g以下、6.6g以下、6.5g以下、6.4g以下、6.3g以下、6.2g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
In addition, the lower limit of the content of palatinose (isomaltulose) per 100 mL of the nutritional composition according to the present invention is preferably 1.2 g or more, 1.5 g or more, 2.0 g or more, 2.5 g or more, 3.0 g or more, more preferably 3.5 g or more, 4.0 g or more, 4.5 g or more, 5.0 g or more, 5.5 g or more, still more preferably 6.0 g or more, 6.1 g or more.
The upper limit of the content of palatinose (isomaltulose) per 100 mL of the nutritional composition according to the present invention is preferably 20.0 g or less, 19.0 g or less, 18.0 g or less, 17.0 g or less, 16.0 g or less, more preferably 15.0 g or less, 14.0 g or less, 13.0 g or less, 12.0 g or less, 11.0 g or less, 10.0 g or less, 9.0 g or less, 8.0 g or less, more preferably is 7.9 g or less, 7.8 g or less, 7.7 g or less, 7.6 g or less, 7.5 g or less, 7.4 g or less, 7.3 g or less, 7.2 g or less, 7.1 g or less, 7.0 g or less , 6.9 g or less, 6.8 g or less, 6.7 g or less, 6.6 g or less, 6.5 g or less, 6.4 g or less, 6.3 g or less, 6.2 g or less. Also, any consistent combination of these may be used.
 糖質中のパラチノース(イソマルツロース)の割合は、下限としては、好ましくは20質量%以上、25質量%以上、より好ましくは30質量%以上、31質量%以上、32質量%以上、33質量%以上、34質量%以上、さらに好ましくは35質量%以上、36質量%以上であり、上限としては、好ましくは、90質量%以下、89質量%以下、88質量%以下、87質量%以下、85質量%以下、80質量%以下、75質量%以下、70質量%以下、65質量%以下、60質量%以下、59質量%以下、58質量%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
 パラチノース(イソマルツロース)の含有量を上記範囲内とすることで、甘みが感じられ、かつ血糖値が上昇しにくくなる。
The lower limit of the proportion of palatinose (isomaltulose) in carbohydrates is preferably 20% by mass or more, 25% by mass or more, more preferably 30% by mass or more, 31% by mass or more, 32% by mass or more, and 33% by mass. % or more, 34% by mass or more, more preferably 35% by mass or more and 36% by mass or more, and the upper limit is preferably 90% by mass or less, 89% by mass or less, 88% by mass or less, 87% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, 65% by mass or less, 60% by mass or less, 59% by mass or less, 58% by mass or less. Also, any consistent combination of these may be used.
By setting the content of palatinose (isomaltulose) within the above range, sweetness can be felt and the blood sugar level is less likely to rise.
 なお、パラチノース(イソマルツロース)以外の二糖類を含有する場合は、パラチノース(イソマルツロース)の含有量を上述の通りにしてもよいし、二糖類の含有量の合計に、上述のパラチノース(イソマルツロース)の含有量を適用してもよい。 When disaccharides other than palatinose (isomaltulose) are contained, the content of palatinose (isomaltulose) may be as described above, or the total content of disaccharides may be added to the above-mentioned palatinose ( isomaltulose) content may be applied.
 また、本発明に係る栄養組成物の100kcalあたりのオリゴ糖の含有量は、下限としては、好ましくは0.1g以上、0.2g以上であり、上限としては、2.0g以下、1.0g以下、0.8g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the oligosaccharide content per 100 kcal of the nutritional composition according to the present invention is preferably 0.1 g or more and 0.2 g or more, and the upper limit is 2.0 g or less and 1.0 g. Below, it is 0.8 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりのオリゴ糖の含有量は、下限としては、好ましくは0.06g以上、0.1g以上、0.2g以上、0.5g以上であり、上限としては、3.0g以下、2.0g以下、1.5g以下、1.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
 オリゴ糖を含むことによって、腸内環境を改善することができる。
The lower limit of the oligosaccharide content per 100 mL of the nutritional composition according to the present invention is preferably 0.06 g or more, 0.1 g or more, 0.2 g or more, or 0.5 g or more, and the upper limit is is 3.0 g or less, 2.0 g or less, 1.5 g or less, or 1.0 g or less. Also, any consistent combination of these may be used.
Intestinal environment can be improved by including oligosaccharides.
 また、本発明に係る栄養組成物の100kcalあたりのデンプン分解物の含有量は、下限としては、好ましくは1.0g以上、2.0g以上、3.0g以上であり、上限としては、好ましくは12.0g以下、11.0g以下、10.0g以下、9.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the content of the starch decomposition product per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more, 2.0 g or more, or 3.0 g or more, and the upper limit is preferably 12.0 g or less, 11.0 g or less, 10.0 g or less, and 9.0 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりのデンプン分解物の含有量は、下限としては、好ましくは0.6g以上、1.0g以上、2.0g以上、3.0g以上であり、上限としては、好ましくは24g以下、22g以下、20g以下、19g以下、18g以下、17g以下、16g以下、15g以下、14g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 In addition, the content of the starch decomposition product per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, and the upper limit is is preferably 24 g or less, 22 g or less, 20 g or less, 19 g or less, 18 g or less, 17 g or less, 16 g or less, 15 g or less, and 14 g or less. Also, any consistent combination of these may be used.
<乳化剤>
 本発明に係る栄養組成物は乳化剤を含み、その含有量は0.60g/100kcal以下である。
 100kcalあたりの乳化剤の含有量は、下限としては、好ましくは0.01g以上、0.02g以上、0.03g以上、0.04g以上、0.05g以上、0.06g以上、0.07g以上、0.08g以上、0.09g以上、0.10g、0.11g以上、0.12g以上、0.13g以上、0.14g以上、0.15g以上である。
 また、100kcalあたりの乳化剤の含有量は、上限としては、好ましくは0.60g以下、0.59g以下、0.58g以下、0.57g以下、0.56g以下、0.55g以下、0.54g以下、0.53g以下、0.52g以下、0.51g以下、0.50g以下、0.49g以下、0.48g以下、0.47g以下、0.46g以下、0.45g以下、0.44g以下、0.43g以下、0.42g以下、0.41g以下、0.40g以下、0.39g以下、0.38g以下、0.37g以下、0.36g以下、0.35g以下、0.34g以下、0.33g以下、0.32g以下、0.31g以下、0.30g以下、0.29g以下、0.28g以下、0.27g以下、0.26g以下、0.25g以下、0.24g以下、0.23g以下、0.22g以下、0.21g以下、0.20g以下、0.19g以下、0.18g以下、0.17g以下、0.16g以下、0.15g以下、0.14g以下、0.13g以下、0.12g以下、0.11g以下、0.10g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
<Emulsifier>
The nutritional composition according to the present invention contains an emulsifier and its content is 0.60 g/100 kcal or less.
The lower limit of the emulsifier content per 100 kcal is preferably 0.01 g or more, 0.02 g or more, 0.03 g or more, 0.04 g or more, 0.05 g or more, 0.06 g or more, 0.07 g or more, 0.08 g or more, 0.09 g or more, 0.10 g, 0.11 g or more, 0.12 g or more, 0.13 g or more, 0.14 g or more, 0.15 g or more.
The upper limit of the emulsifier content per 100 kcal is preferably 0.60 g or less, 0.59 g or less, 0.58 g or less, 0.57 g or less, 0.56 g or less, 0.55 g or less, 0.54 g. 0.53 g or less, 0.52 g or less, 0.51 g or less, 0.50 g or less, 0.49 g or less, 0.48 g or less, 0.47 g or less, 0.46 g or less, 0.45 g or less, 0.44 g 0.43 g or less, 0.42 g or less, 0.41 g or less, 0.40 g or less, 0.39 g or less, 0.38 g or less, 0.37 g or less, 0.36 g or less, 0.35 g or less, 0.34 g 0.33 g or less, 0.32 g or less, 0.31 g or less, 0.30 g or less, 0.29 g or less, 0.28 g or less, 0.27 g or less, 0.26 g or less, 0.25 g or less, 0.24 g 0.23 g or less, 0.22 g or less, 0.21 g or less, 0.20 g or less, 0.19 g or less, 0.18 g or less, 0.17 g or less, 0.16 g or less, 0.15 g or less, 0.14 g 0.13 g or less, 0.12 g or less, 0.11 g or less, and 0.10 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりの乳化剤の含有量は、下限としては、好ましくは以上0.006g以上、より好ましくは0.01g以上、さらに好ましくは0.10g以上、特に好ましくは0.20g以上である。
 また、本発明に係る栄養組成物100mLあたりの乳化剤の含有量は、上限としては、好ましくは0.50g以下、より好ましくは0.30g以下、さらに好ましくは0.20g以下、特に好ましくは0.15g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
The lower limit of the content of the emulsifier per 100 mL of the nutritional composition according to the present invention is preferably 0.006 g or more, more preferably 0.01 g or more, still more preferably 0.10 g or more, and particularly preferably 0.20 g or more.
The upper limit of the content of the emulsifier per 100 mL of the nutritional composition according to the present invention is preferably 0.50 g or less, more preferably 0.30 g or less, even more preferably 0.20 g or less, and particularly preferably 0.2 g or less. 15 g or less. Also, any consistent combination of these may be used.
 また、脂質の含有量に対する乳化剤の含有量の比率は、下限としては、好ましくは1.0質量%以上、より好ましくは1.5質量%以上、2.0質量%以上、3.0質量%以上、さらに好ましくは3.5質量%以上、3.6質量%以上、3.7質量%以上、3.8質量%以上、3.9質量%以上である。
 また、脂質の含有量に対する乳化剤の含有量の比率は、上限としては、好ましくは6.5質量%以下、6.0質量%以下、5.5質量%以下、5.0質量%以下、より好ましくは4.5質量%以下、4.4質量%以下、4.3質量%以下、4.2質量%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
In addition, the ratio of the emulsifier content to the lipid content is preferably 1.0% by mass or more, more preferably 1.5% by mass or more, 2.0% by mass or more, and 3.0% by mass as a lower limit. Above, more preferably 3.5% by mass or more, 3.6% by mass or more, 3.7% by mass or more, 3.8% by mass or more, and 3.9% by mass or more.
In addition, the upper limit of the ratio of the emulsifier content to the lipid content is preferably 6.5% by mass or less, 6.0% by mass or less, 5.5% by mass or less, 5.0% by mass or less, or more. It is preferably 4.5% by mass or less, 4.4% by mass or less, 4.3% by mass or less, and 4.2% by mass or less. Also, any consistent combination of these may be used.
 乳化剤の含有量を上記上限以下とすることで、乳化剤に特有の風味を低減することができる。本発明に係る栄養組成物は、乳化剤の含有量を上記範囲内としても、良好な乳化安定性を有する。 By keeping the content of the emulsifier below the above upper limit, it is possible to reduce the flavor peculiar to the emulsifier. The nutritional composition according to the present invention has good emulsion stability even when the content of the emulsifier is within the above range.
 乳化剤としては、食用として用いることができるものであれば特に制限されず、レシチン、有機酸モノグリセリド、グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ショ糖脂肪酸エステル等が例示できる。
 その中でもレシチン、有機酸モノグリセリドを好ましく用いることができる。
 レシチンと有機酸モノグリセリドの両方を含むことが特に好ましく、その質量比は、好ましくは1:9~9:1、より好ましくは3:7~7:3、さらに好ましくは4:6~6:4である。
The emulsifier is not particularly limited as long as it can be used as food, and examples thereof include lecithin, organic acid monoglyceride, glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, and sucrose fatty acid ester.
Among them, lecithin and organic acid monoglyceride can be preferably used.
It is particularly preferred to contain both lecithin and organic acid monoglyceride, preferably in a mass ratio of 1:9 to 9:1, more preferably 3:7 to 7:3, even more preferably 4:6 to 6:4. is.
<食物繊維>
 本発明に係る栄養組成物は、食物繊維を含むことが好ましい。
 食物繊維として水溶性食物繊維を用いることが好ましい。また、血糖値上昇抑制効果を有する食物繊維を用いることが好ましい。食物繊維は、高粘性または低粘性のいずれのものも使用することができる。
 血糖値上昇抑制効果を有することが知られている水溶性食物繊維としては、イヌリン、難消化性デキストリン、ポリデキストロース、グァーガム分解物、ペクチン、グルコマンナン、βグルカン、アルギン酸塩、グァーガム、寒天などを好適に例示することができる。これらの1又は複数を配合することも可能である。特に、難消化性デキストリン及びイヌリンから選ばれる1又は複数を好ましく用いることができる。
<Dietary fiber>
The nutritional composition according to the present invention preferably contains dietary fiber.
It is preferable to use water-soluble dietary fiber as dietary fiber. Moreover, it is preferable to use a dietary fiber having an effect of suppressing an increase in blood sugar level. Either high-viscosity or low-viscosity dietary fiber can be used.
Water-soluble dietary fibers known to have the effect of suppressing elevation of blood sugar include inulin, indigestible dextrin, polydextrose, guar gum decomposition product, pectin, glucomannan, β-glucan, alginate, guar gum, and agar. A suitable example can be given. It is also possible to blend one or more of these. In particular, one or more selected from indigestible dextrin and inulin can be preferably used.
 本発明に係る栄養組成物の100kcalあたりの食物繊維の含有量は、下限としては、好ましくは1.0g以上、2.0g以上であり、上限としては、好ましくは5.0g以下、4.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the dietary fiber content per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more and 2.0 g or more, and the upper limit is preferably 5.0 g or less and 4.0 g. It is below. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりの食物繊維の含有量は、下限としては、好ましくは0.6g以上、1.0g以上、1.5g以上、2.0g以上であり、上限としては、好ましくは10.0g以下、9.0g以下、8.0g以下、7.0g以下、6.0g以下、5.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the content of dietary fiber per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 1.5 g or more, 2.0 g or more, and the upper limit is is preferably 10.0 g or less, 9.0 g or less, 8.0 g or less, 7.0 g or less, 6.0 g or less, or 5.0 g or less. Also, any consistent combination of these may be used.
 本発明に係る栄養組成物の100kcalあたりのイヌリンの含有量は、下限としては、好ましくは0.1g以上、0.5g以上であり、上限としては、好ましくは2.5g以下、2.0g以下、1.5g以下、1.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the inulin content per 100 kcal of the nutritional composition according to the present invention is preferably 0.1 g or more and 0.5 g or more, and the upper limit is preferably 2.5 g or less and 2.0 g or less. , 1.5 g or less, and 1.0 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりのイヌリンの含有量は、下限としては、好ましくは0.06g以上、0.1g以上、0.2g以上、0.3g以上、0.4g以上、0.5g以上、1.0g以上であり、上限としては、好ましくは4.0g以下、3.5g以下、3.0g以下、2.5g以下、2.0g以下、1.5g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the content of inulin per 100 mL of the nutritional composition according to the present invention is preferably 0.06 g or more, 0.1 g or more, 0.2 g or more, 0.3 g or more, 0.4 g or more, It is 0.5 g or more and 1.0 g or more, and the upper limit is preferably 4.0 g or less, 3.5 g or less, 3.0 g or less, 2.5 g or less, 2.0 g or less, and 1.5 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100kcalあたりの難消化性デキストリンの含有量は、下限としては、好ましくは1.0g以上、2.0g以上であり、上限としては、好ましくは4.0g以下、3.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 In addition, the content of indigestible dextrin per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more and 2.0 g or more as a lower limit, and preferably 4.0 g or less as an upper limit. , 3.0 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりの難消化性デキストリンの含有量は、下限としては、好ましくは0.6g以上、1.0g以上、2.0g以上、3.0g以上であり、上限としては、好ましくは8.0g以下、6.0g以下、4.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。
 食物繊維を含むことによって、腸内環境を改善することができる。また、血糖値抑制作用を有する食物繊維を含むことによって、栄養組成物の血糖値抑制効果をより高めることができる。
In addition, the lower limit of the content of the indigestible dextrin per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, The upper limit is preferably 8.0 g or less, 6.0 g or less, or 4.0 g or less. Also, any consistent combination of these may be used.
Intestinal environment can be improved by including dietary fiber. In addition, by including dietary fiber having a blood sugar level suppressing effect, the blood sugar level suppressing effect of the nutritional composition can be further enhanced.
<たんぱく質>
 本発明に係る栄養組成物は、たんぱく質を含むことが好ましい。たんぱく質の種類は、乳たんぱく質、卵たんぱく質、コラーゲン等の動物性たんぱく質、大豆たんぱく質、米たんぱく質、小麦たんぱく質等の植物性たんぱく質等、食品に用いられるものであれば特に制限されない。本発明において、乳たんぱく質が特に好ましく用いられる。乳たんぱく質として、カゼイン、ナトリウムカゼイネート、カルシウムカゼイネート、カリウムカゼイネート、ミセラカゼイン(MCC)、乳たんぱく質濃縮物(MPC)、乳たんぱく質分離物(MPI)、乳たんぱく質加水分解物(MPH)、濃縮ホエイたんぱく質(WPC)、ホエイたんぱく質分離物(WPI)等を用いることができる。
<Protein>
The nutritional composition according to the invention preferably contains protein. The type of protein is not particularly limited as long as it is used for foods, such as milk protein, egg protein, animal protein such as collagen, vegetable protein such as soybean protein, rice protein, and wheat protein. Milk proteins are particularly preferably used in the present invention. As milk proteins, casein, sodium caseinate, calcium caseinate, potassium caseinate, micellar casein (MCC), milk protein concentrate (MPC), milk protein isolate (MPI), milk protein hydrolyzate (MPH), concentrate Whey protein (WPC), whey protein isolate (WPI) and the like can be used.
 本発明に係る栄養組成物の100kcalあたりのたんぱく質の含有量は、下限としては、好ましくは1.0g以上、2.0g以上、3.0g以上であり、上限としては、好ましくは6.0g以下、5.0g以下、4.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the protein content per 100 kcal of the nutritional composition according to the present invention is preferably 1.0 g or more, 2.0 g or more, or 3.0 g or more, and the upper limit is preferably 6.0 g or less. , 5.0 g or less, and 4.0 g or less. Also, any consistent combination of these may be used.
 また、本発明に係る栄養組成物の100mLあたりのたんぱく質の含有量は、下限としては、好ましくは0.6g以上、1.0g以上、2.0g以上、3.0g以上、4.0g以上、5.0g以上であり、上限としては、好ましくは12.0g以下、10.0g以下、7.0g以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the protein content per 100 mL of the nutritional composition according to the present invention is preferably 0.6 g or more, 1.0 g or more, 2.0 g or more, 3.0 g or more, 4.0 g or more, It is 5.0 g or more, and the upper limit is preferably 12.0 g or less, 10.0 g or less, or 7.0 g or less. Also, any consistent combination of these may be used.
<その他の成分>
 本発明に係る栄養組成物には、本技術の効果を損なわない範囲内で、適宜任意成分を用いることができる。任意成分として、例えば、ビタミン、ミネラル、カルチニン、乳・乳製品、安定化剤、増粘剤、pH調整剤、矯味矯臭剤、香料、色素、ビフィズス菌粉末、乳酸菌粉末が挙げられる。
<Other ingredients>
Arbitrary components can be appropriately used in the nutritional composition according to the present invention within a range that does not impair the effects of the present technology. Optional ingredients include, for example, vitamins, minerals, carnitine, milk/dairy products, stabilizers, thickeners, pH adjusters, flavoring agents, fragrances, pigments, bifidobacterium powder, and lactic acid bacteria powder.
[熱量]
 本発明に係る栄養組成物の熱量は、好ましくは0.6kcal/mL以上、1.0kcal/mL以上、1.3kcal/mL以上、1.4kcal/mL以上、1.5kcal/mL以上、1.6kcal/mL以上、1.7kcal/mL以上、1.8kcal/mL以上、1.9kcal/mL以上、2.0kcal/mL以上である。
 栄養組成物の熱量を上記範囲とすることで、効率よくエネルギーを摂取することができる。
[calorie]
The calorie content of the nutritional composition according to the present invention is preferably 0.6 kcal/mL or more, 1.0 kcal/mL or more, 1.3 kcal/mL or more, 1.4 kcal/mL or more, 1.5 kcal/mL or more. 6 kcal/mL or more, 1.7 kcal/mL or more, 1.8 kcal/mL or more, 1.9 kcal/mL or more, 2.0 kcal/mL or more.
By setting the calorie of the nutritional composition within the above range, energy can be ingested efficiently.
 本発明に係る栄養組成物の熱量は、主に脂質、炭水化物、たんぱく質に由来する熱量であることが好ましい。
 本明細書において、脂質エネルギー比率、炭水化物エネルギー比率、たんぱく質エネルギー比率とは、栄養組成物中の熱量のうち、脂質、炭水化物、たんぱく質にそれぞれに由来する熱量の比率を示す。
The calorific value of the nutritional composition according to the present invention is preferably calorific value mainly derived from lipids, carbohydrates, and proteins.
As used herein, the lipid energy ratio, carbohydrate energy ratio, and protein energy ratio refer to the ratio of the calorie derived from lipids, carbohydrates, and proteins to the calorie in the nutritional composition.
 本発明に係る栄養組成物の脂質エネルギー比率は、下限としては、好ましくは30%以上、35%以上、40%以上であり、上限としては、好ましくは60%以下、55%以下、50%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the lipid energy ratio of the nutritional composition according to the present invention is preferably 30% or more, 35% or more, and 40% or more, and the upper limit is preferably 60% or less, 55% or less, and 50% or less. is. Also, any consistent combination of these may be used.
 本発明に係る栄養組成物の炭水化物エネルギー比率は、下限としては、好ましくは30%以上、35%以上、40%以上であり、上限としては、好ましくは60%以下、55%以下、50%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 Regarding the carbohydrate energy ratio of the nutritional composition according to the present invention, the lower limit is preferably 30% or more, 35% or more and 40% or more, and the upper limit is preferably 60% or less, 55% or less and 50% or less. is. Also, any consistent combination of these may be used.
 また、炭水化物エネルギー比率の中でも、糖質に由来するエネルギーの比率を、糖質エネルギー比率と呼ぶ。本発明に係る栄養組成物の糖質エネルギー比率は、下限としては、好ましくは25%以上、30%以上、35%以上であり、上限としては、好ましくは55%以下、50%以下、45%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 Also, among the carbohydrate energy ratios, the ratio of energy derived from carbohydrates is called the carbohydrate energy ratio. The carbohydrate energy ratio of the nutritional composition according to the present invention has a lower limit of preferably 25% or more, 30% or more and 35% or more, and an upper limit of preferably 55% or less, 50% or less and 45%. It is below. Also, any consistent combination of these may be used.
 本発明に係る栄養組成物のたんぱく質エネルギー比率は、下限としては、好ましくは5%以上、10%以上であり、上限としては、好ましくは25%以下、20%以下である。また、これらの矛盾しない任意の組み合わせであってもよい。 The lower limit of the protein energy ratio of the nutritional composition according to the present invention is preferably 5% or more and 10% or more, and the upper limit is preferably 25% or less and 20% or less. Also, any consistent combination of these may be used.
[血糖値上昇抑制用の栄養組成物]
 本発明に係る栄養組成物は、血糖値上昇抑制用であることが好ましい。
 本明細書において「血糖値上昇抑制」及び「血糖値上昇を抑制」は、特に食後において、血糖値の急激な上昇を抑制する作用、血糖値を低下ないし降下させる作用、糖の吸収を緩やかにする作用、高血糖状態を改善する作用などを指す。
 本発明の栄養組成物は、血糖値上昇抑制用とすることができる。
[Nutritional composition for suppressing elevation of blood sugar level]
The nutritional composition according to the present invention is preferably for suppressing elevation of blood sugar level.
As used herein, "suppression of blood sugar level rise" and "suppression of blood sugar level rise" refer to the action of suppressing a rapid rise in blood sugar level, the action of lowering or lowering blood sugar level, and the action of slowing the absorption of sugar, especially after a meal. It refers to the action to improve hyperglycemia and the action to improve hyperglycemia.
The nutritional composition of the present invention can be used for suppressing elevation of blood sugar level.
[形態]
 本発明に係る栄養組成物は、液状でも半固形状でもよいが、特に液状であることが好ましい。
 本発明に係る栄養組成物の20℃における粘度は、上限としては、好ましくは100000mPa・s以下、10000mPa・s以下、1000mPa・s以下、100mPa・s以下、50mPa・s以下、30mPa・s以下である。
 また、本発明に係る栄養組成物の20℃における粘度は、下限としては、0.1mPa・s以上、より好ましくは1mPa・s以上である。
[form]
The nutritional composition according to the present invention may be in liquid or semi-solid form, but liquid form is particularly preferred.
The upper limit of the viscosity at 20° C. of the nutritional composition according to the present invention is preferably 100000 mPa·s or less, 10000 mPa·s or less, 1000 mPa·s or less, 100 mPa·s or less, 50 mPa·s or less, or 30 mPa·s or less. be.
The lower limit of the viscosity at 20° C. of the nutritional composition according to the present invention is 0.1 mPa·s or more, more preferably 1 mPa·s or more.
 また、本発明に係る栄養組成物は、経口用の栄養組成物として提供できる他、経鼻投与用の栄養組成物、胃瘻チューブ投与用の栄養組成物として提供することもできる。 In addition, the nutritional composition according to the present invention can be provided as an oral nutritional composition, as well as a nutritional composition for nasal administration and a nutritional composition for gastrostomy tube administration.
[製造方法]
 本発明の栄養組成物は、脂質を含む油相と、糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化させることによって、製造することができる。水相は、好ましくはたんぱく質及び糖質を含む。
 その他好ましい態様としては、上述の好ましい態様を適用することができる。
[Production method]
The nutritional composition of the present invention can be produced by preparing an oil phase containing lipids and an aqueous phase containing carbohydrates, and emulsifying them by adding an emulsifier. The aqueous phase preferably contains proteins and carbohydrates.
As other preferred aspects, the preferred aspects described above can be applied.
 油相と水相の質量比は、1:6~1:60であることが好ましい。 The mass ratio of the oil phase to the water phase is preferably 1:6 to 1:60.
[乳化安定性向上方法]
 また、本発明は、栄養組成物の乳化安定性向上方法であって、脂質を含む油相と、糖質を含む水相とを調製する調製工程と、前記油相及び前記水相を、0.60g/100kcal以下の乳化剤を添加して混合する乳化工程とを含み、前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、乳化安定性向上方法でもある。水相は、好ましくはたんぱく質及び糖質を含む。
 上記乳化安定性向上方法は、特に、パラチノース(イソマルツロース)を含む栄養組成物において、乳化安定性を向上させる。
 その他好ましい態様としては、上述の好ましい態様を適用することができる。
[Method for improving emulsion stability]
The present invention also provides a method for improving the emulsion stability of a nutritional composition, comprising: a preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates; and an emulsification step of adding and mixing an emulsifier of 60 g/100 kcal or less, wherein the content of the lipid in the nutritional composition is 3.5 g/100 kcal or more, and the lipid contains all its constituent fatty acids. It is also a method for improving emulsification stability by including medium-chain fatty acids in a proportion of 20% by mass or more. The aqueous phase preferably contains proteins and carbohydrates.
The method for improving emulsion stability improves emulsion stability, particularly in nutritional compositions containing palatinose (isomaltulose).
As other preferred aspects, the preferred aspects described above can be applied.
<試験例1:乳化安定性試験(脂質含有量の影響)>
 試験例1では、乳化安定性に対する脂質含有量による影響を調べるため、脂質含有量の異なる2つのサンプルを調製し、乳化安定性を調べた。
 脂質を含む油相と、たんぱく質及び糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化さることによって、栄養組成物を製造した。乳化剤として、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。対照例、及び比較例1-1の熱量は1.6kcal/mL、たんぱく質含有量は3.8g/100kcalとなるように調製した。
 また、対照例、及び比較例1-1の脂質の脂質エネルギー比率、脂質含有量、全構成脂肪酸中の中鎖脂肪酸の割合(中鎖脂肪酸比率)、糖質エネルギー比率、糖質含有量、パラチノース(イソマルツロース)含有量、乳化剤含有量は表1に示す通りである。
<Test Example 1: Emulsion stability test (effect of lipid content)>
In Test Example 1, in order to examine the effect of lipid content on emulsion stability, two samples with different lipid contents were prepared and the emulsion stability was examined.
A nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, respectively, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1. The control example and comparative example 1-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
In addition, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in the total constituent fatty acids (medium-chain fatty acid ratio), carbohydrate energy ratio, carbohydrate content, and palatinose of the lipids of the control example and Comparative Example 1-1 (Isomaltulose) content and emulsifier content are as shown in Table 1.
 製造した栄養組成物28mLを50mL容の遠沈管に入れ、5000g、3分間、20℃にて遠心分離を行い脂肪の浮上を促した後、乳化安定性について以下の評価を行った。 28 mL of the produced nutritional composition was placed in a 50 mL centrifuge tube and centrifuged at 5000 g for 3 minutes at 20°C to encourage fat to float, and then the emulsification stability was evaluated as follows.
・遠沈管への脂肪付着
 遠心分離後に液状の内容物を別の容器に移した後、遠沈管上部に残留した脂肪成分の量を目視によって評価した。-~+++の評価基準は以下の通りである。1つの試験内で、脂肪付着が明らかにあるもののうち、最も量が少ないものを+とした。++、+++については、脂肪付着が明らかにあるもののうち、最も量が少ないものを基準とした相対量とした。また、脂肪付着が明らかにあるもののうち、最も量が少ないものに対し脂肪付着が2倍未満のものは、+とした。
 遠沈管への脂肪付着の量が少ないほど乳化安定性が良いといえる。
-:脂肪付着がまったく認められない
±:脂肪付着が明瞭ではないがある
+:脂肪付着が明らかにある
++:脂肪付着が+の2倍以上3倍未満ある
+++:脂肪付着が+の3倍以上ある
- Adherence of fat to centrifuge tube After the liquid content was transferred to another container after centrifugation, the amount of fat component remaining in the upper part of the centrifuge tube was visually evaluated. The evaluation criteria of - to +++ are as follows. Among those with obvious fat deposits within one test, the lowest amount was designated as +. For ++ and +++, the relative amount was determined based on the lowest amount among those with obvious fat deposits. In addition, among those with clearly adhered fat, those with less than twice the amount of adherent fat as the smallest amount were marked as +.
It can be said that the smaller the amount of fat adhering to the centrifuge tube, the better the emulsification stability.
-: No fat attachment ±: Fat attachment is not clear +: Fat attachment is clearly observed ++: Fat attachment is 2 to 3 times + +++: Fat attachment is 3 times + more than
・遠沈管残留物の重量
 遠心分離後に液状の内容物を別の容器に移した後、遠沈管の重量を測定し、あらかじめ測定した遠沈管のみの重量を差し引いて、遠沈管残留物分の重量を測定した。遠沈管残留物分の重量は、遠沈管上部に付着した脂肪成分と遠沈管下部に残留した沈殿物の総重量であり、少ないほど乳化安定性が良いといえる。
・Weight of centrifuge tube residue Transfer the liquid contents to another container after centrifugation, measure the weight of the centrifuge tube, subtract the previously measured weight of the centrifuge tube alone, and calculate the weight of the centrifuge tube residue. was measured. The weight of the residue in the centrifuge tube is the total weight of the fat component adhering to the upper part of the centrifuge tube and the sediment remaining in the lower part of the centrifuge tube.
・脂肪付着相対面積
 遠心分離後に液状の内容物を別の容器に移した後、脂肪付着が見られる、遠心分離の際に内側となった側面を正面とし、写真を撮影した(図1)。画像解析ソフトImageJを用いて、脂肪付着部位周囲を四角形で囲い評価範囲とし、評価範囲内における脂肪付着面積を数値化した。同時に評価する遠沈管は同じ形状および面積の四角形を評価範囲とした。対照例の脂肪付着面積を1.000とし、比較例1-1の脂肪付着面積を相対的に算出し、脂肪付着相対面積とした。脂肪付着相対面積が少ないほど、乳化安定性が良いといえる。
・Fat adhesion relative area After the liquid content was transferred to another container after centrifugation, a photograph was taken with the side that became the inner side during centrifugation, where the fat adhesion was observed, as the front (Fig. 1). Using the image analysis software ImageJ, the periphery of the fat deposit area was defined by a rectangle as an evaluation range, and the fat deposit area within the evaluation range was quantified. The centrifuge tubes to be evaluated at the same time were evaluated in the same rectangular shape and area as the evaluation range. Taking the fat deposit area of the control example as 1.000, the fat deposit area of Comparative Example 1-1 was relatively calculated and used as the fat deposit relative area. It can be said that the smaller the relative fat adhesion area, the better the emulsification stability.
 結果を表2に示す。また、脂肪付着相対面積の結果のグラフを図2に示す。 The results are shown in Table 2. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
 いずれの評価でも、対照例と比較して、比較例1-1の方が、乳化剤含有量が多いにもかかわらず、乳化安定性が低かった。
 以上より、栄養組成物の脂質含有量を多くすると、乳化安定性が低下する傾向が示された。
In both evaluations, the emulsification stability was lower in Comparative Example 1-1 than in Control Example, although the emulsifier content was higher.
From the above, it was shown that when the lipid content of the nutritional composition was increased, the emulsification stability tended to decrease.
<試験例2:乳化安定性試験(パラチノース(イソマルツロース)含有量の影響)>
 試験例2では、乳化安定性に対するパラチノース(イソマルツロース)含有量による影響を調べるため、パラチノース(イソマルツロース)含有量の異なるサンプルを調製し、乳化安定性を調べた。
 脂質を含む油相と、たんぱく質及び糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化させることによって、栄養組成物を製造した。乳化剤として、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。対照例、及び比較例2-1~2-6の熱量は1.6kcal/mL、たんぱく質含有量は3.8g/100kcalとなるように調製した。
 また、対照例、及び比較例2-1~2-6の脂質の脂質エネルギー比率、脂質含有量、全構成脂肪酸中の中鎖脂肪酸の割合、糖質エネルギー比率、糖質含有量、パラチノース(イソマルツロース)含有量、乳化剤含有量は表3に示す通りである。
 表3に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、対照例の面積を1.000として算出した。
 結果を表4に示す。また、脂肪付着相対面積の評価の際の写真を図3に示す。また、脂肪付着相対面積の結果のグラフを図4に示す。
<Test Example 2: Emulsion stability test (influence of palatinose (isomaltulose) content)>
In Test Example 2, in order to examine the effect of the palatinose (isomaltulose) content on emulsion stability, samples with different palatinose (isomaltulose) contents were prepared and the emulsion stability was examined.
A nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1. Control and Comparative Examples 2-1 to 2-6 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
In addition, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, carbohydrate content, palatinose (iso Maltulose) content and emulsifier content are as shown in Table 3.
The same test as in Test Example 1 was performed on the samples shown in Table 3. The fat deposit relative area was calculated with the area of the control example set at 1.000.
Table 4 shows the results. In addition, FIG. 3 shows a photograph taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
 いずれの評価でも、パラチノース(イソマルツロース)の含有量が多いほど乳化安定性が悪化する傾向がみられた。
 以上より、脂質を一定以上含む栄養組成物において、パラチノース(イソマルツロース)は乳化安定性を用量依存的に悪化させることが示された。
In both evaluations, there was a tendency that the higher the content of palatinose (isomaltulose), the worse the emulsion stability.
From the above, it was shown that palatinose (isomaltulose) dose-dependently deteriorates emulsification stability in nutritional compositions containing a certain amount or more of lipids.
<試験例3:乳化安定性試験(中鎖脂肪酸比率の影響)>
 試験例3~9では、乳化安定性に対する中鎖脂肪酸比率による影響を調べるため、中鎖脂肪酸比率の異なるサンプルを調製し、乳化安定性を調べた。
 脂質を含む油相と、たんぱく質及び糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化させることによって、栄養組成物を製造した。乳化剤として、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。対照例、及び比較例3-1、実施例3-1の熱量は1.6kcal/mL、たんぱく質含有量は3.8g/100kcalとなるように調製した。
 また、対照例、及び比較例3-1、実施例3-1の脂質の脂質エネルギー比率、脂質含有量、全構成脂肪酸中の中鎖脂肪酸の割合、糖質エネルギー比率、糖質含有量、パラチノース(イソマルツロース)含有量、乳化剤含有量は表5に示す通りである。
 表5に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、対照例の面積を1.000として算出した。
 結果を表6に示す。また、脂肪付着相対面積の評価の際の写真を図5に示す。また、脂肪付着相対面積の結果のグラフを図6に示す。
<Test Example 3: Emulsion stability test (influence of medium-chain fatty acid ratio)>
In Test Examples 3 to 9, in order to examine the influence of medium-chain fatty acid ratios on emulsion stability, samples with different medium-chain fatty acid ratios were prepared and their emulsion stability was examined.
A nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1. The control, comparative example 3-1, and example 3-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
In addition, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, carbohydrate content, and palatinose of the lipids in the control example, Comparative Example 3-1, and Example 3-1 (Isomaltulose) content and emulsifier content are as shown in Table 5.
The same test as in Test Example 1 was performed on the samples shown in Table 5. The fat deposit relative area was calculated with the area of the control example set at 1.000.
Table 6 shows the results. In addition, FIG. 5 shows a photograph taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
 いずれの評価でも、比較例3-1と比較して、中鎖脂肪酸比率の高い実施例3-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量0g/100kcalの栄養組成物において、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 3-1, which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 3-1.
From the above, it was shown that in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 0 g/100 kcal, increasing the ratio of medium-chain fatty acids improves emulsion stability.
<試験例4:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表7に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例4-1の面積を1.000として算出した。
 結果を表7に示す。また、脂肪付着相対面積の評価の際の写真を図7に示す。また、脂肪付着相対面積の結果のグラフを図8に示す。
<Test Example 4: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 7 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 4-1 to 1.000.
Table 7 shows the results. In addition, FIG. 7 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
 いずれの評価でも、比較例4-1と比較して、中鎖脂肪酸比率の高い実施例4-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量2.29g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 4-1, which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 4-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 2.29 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
<試験例5:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表8に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例5-1の面積を1.000として算出した。
 結果を表8に示す。また、脂肪付着相対面積の評価の際の写真を図9に示す。また、脂肪付着相対面積の結果のグラフを図10に示す。
<Test Example 5: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 8 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 5-1 to 1.000.
Table 8 shows the results. In addition, FIG. 9 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000008
Figure JPOXMLDOC01-appb-T000008
 いずれの評価でも、比較例5-1と比較して、中鎖脂肪酸比率の高い実施例5-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量3.86g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 5-1, which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 5-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
<試験例6:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表9に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例6-1の面積を1.000として算出した。
 結果を表9に示す。また、脂肪付着相対面積の評価の際の写真を図11に示す。また、脂肪付着相対面積の結果のグラフを図12に示す。
<Test Example 6: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 9 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 6-1 to 1.000.
Table 9 shows the results. In addition, FIG. 11 shows a photograph taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000009
 いずれの評価でも、比較例6-1と比較して、中鎖脂肪酸比率の高い実施例6-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量4.58g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 6-1, which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 6-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 4.58 g/100 kcal, the emulsification stability is improved by increasing the ratio of medium-chain fatty acids.
<試験例7:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表10に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例7-1の面積を1.000として算出した。
 結果を表10に示す。また、脂肪付着相対面積の評価の際の写真を図13に示す。また、脂肪付着相対面積の結果のグラフを図14に示す。
<Test Example 7: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 10 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1, except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 7-1 to 1.000.
Table 10 shows the results. In addition, FIG. 13 shows a photograph taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000010
Figure JPOXMLDOC01-appb-T000010
 いずれの評価でも、比較例7-1と比較して、中鎖脂肪酸比率の高い実施例7-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量6.11g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 7-1, which has a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 7-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 6.11 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
<試験例8:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表11に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例8-1の面積を1.000として算出した。
 結果を表11に示す。また、脂肪付着相対面積の評価の際の写真を図15に示す。また、脂肪付着相対面積の結果のグラフを図16に示す。
<Test Example 8: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 11 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 8-1 to 1.000.
Table 11 shows the results. In addition, FIG. 15 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000011
Figure JPOXMLDOC01-appb-T000011
 いずれの評価でも、比較例8-1と比較して、中鎖脂肪酸比率の高い実施例8-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量6.87g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 8-1, which had a higher medium-chain fatty acid ratio, showed better emulsification stability than Comparative Example 8-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 6.87 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
<試験例9:乳化安定性試験(中鎖脂肪酸比率の影響)>
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表12に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例9-1の面積を1.000として算出した。
 結果を表12に示す。また、脂肪付着相対面積の評価の際の写真を図17に示す。また、脂肪付着相対面積の結果のグラフを図18に示す。
<Test Example 9: Emulsion stability test (influence of medium-chain fatty acid ratio)>
The samples listed in Table 12 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 9-1 to 1.000.
Table 12 shows the results. In addition, FIG. 17 shows a photograph of evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000012
Figure JPOXMLDOC01-appb-T000012
 いずれの評価でも、比較例9-1と比較して、中鎖脂肪酸比率の高い実施例9-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量9.16g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Example 9-1, which had a higher medium-chain fatty acid ratio, showed better emulsion stability than Comparative Example 9-1.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 9.16 g/100 kcal, the emulsification stability is improved by increasing the medium-chain fatty acid ratio.
 試験例3~9の結果より、パラチノース(イソマルツロース)の含有量が0~9.16g/100kcalの範囲内で、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。 From the results of Test Examples 3 to 9, it was shown that when the content of palatinose (isomaltulose) is within the range of 0 to 9.16 g/100 kcal and the medium chain fatty acid ratio is increased, the emulsion stability is improved.
<試験例10:乳化安定性試験(さらに乳化剤含有量を減らした場合の比較)>
 試験例10では、さらに乳化剤含有量を減らした場合の、乳化安定性対するパラチノース(イソマルツロース)含有量と中鎖脂肪酸比率の影響について調べた。
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量と、乳化剤含有量以外は、比較例3-1と同じ条件で、表13に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例10-1の面積を1.000として算出した。
 結果を表13に示す。また、脂肪付着相対面積の評価の際の写真を図19に示す。また、脂肪付着相対面積の結果のグラフを図20に示す。
<Test Example 10: Emulsion stability test (comparison when the emulsifier content is further reduced)>
In Test Example 10, the effects of the palatinose (isomaltulose) content and medium-chain fatty acid ratio on the emulsion stability were investigated when the emulsifier content was further reduced.
Except for the ratio of medium-chain fatty acids in the total constituent fatty acids, the content of palatinose (isomaltulose), and the content of emulsifier, the samples shown in Table 13 were tested under the same conditions as in Comparative Example 3-1, as in Test Example 1. A similar test was performed. The fat deposit relative area was calculated by setting the area of Comparative Example 10-1 to 1.000.
The results are shown in Table 13. In addition, FIG. 19 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000013
Figure JPOXMLDOC01-appb-T000013
 いずれの評価でも、比較例10-1と比較して、実施例10-1の方が、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い栄養組成物において、乳化剤含有量を少なくしても、脂質の構成脂肪酸中の中鎖脂肪酸比率を高くすることと、パラチノース(イソマルツロース)を含むことの組み合わせによって、高脂肪であっても乳化安定性が良好な液状栄養組成物が得られることが示された。
In both evaluations, Example 10-1 showed better emulsification stability than Comparative Example 10-1.
From the above, in a nutritional composition with a high fat content, even if the emulsifier content is reduced, the combination of increasing the ratio of medium-chain fatty acids in the fatty acids constituting the lipid and containing palatinose (isomaltulose) , it was shown that a liquid nutritional composition with good emulsification stability can be obtained even if it is high in fat.
<試験例11:血糖値測定>
 試験例11では、栄養組成物の摂取による血糖値への影響を調べた。
 脂質を含む油相と、たんぱく質および糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化させることによって、栄養組成物を製造した。乳化剤として、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。対照例、及び実施例11-1の熱量は1.6kcal/mL、たんぱく質含有量は3.8g/100kcalとなるように調製した。
 また、対照例、及び実施例11-1の脂質の脂質エネルギー比率、脂質含有量、全構成脂肪酸中の中鎖脂肪酸の割合、糖質エネルギー比率、糖質含有量、パラチノース(イソマルツロース)含有量、乳化剤含有量は表14に示す通りである。
 対象者は成人男女9名とした。試験開始から終了までにFreestyleリブレProセンサー(アボットジャパン合同会社製)を上腕に装着し、15分毎に血糖値を測定した。朝空腹時に1時間安静にした後、いずれかの試験食品125mLを摂取し、その後さらに2時間安静に過ごした。その後3日以上の間隔を空け、もう一方の試験食品について同様に試験を実施した。朝空腹時の血糖値を差し引いた血糖値上昇量および曲線下面積を評価した。各時点の血糖上昇量および曲線下面積の平均値を算出し、対照例と実施例11-1との有意差検定を対応のあるt検定にて行い、危険率5%以下を有意とした。
<Test Example 11: Blood sugar level measurement>
In Test Example 11, the effect of ingestion of the nutritional composition on the blood sugar level was investigated.
A nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, respectively, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1. The control and Example 11-1 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
In addition, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in the total constituent fatty acids, carbohydrate energy ratio, carbohydrate content, and palatinose (isomaltulose) content of the lipid in the control example and Example 11-1 The amount and emulsifier content are as shown in Table 14.
The subjects were nine adult men and women. From the start to the end of the test, a Freestyle Libre Pro sensor (manufactured by Abbott Japan LLC) was worn on the upper arm, and the blood sugar level was measured every 15 minutes. After resting for 1 hour on an empty stomach in the morning, they ingested 125 mL of either test food, and then rested for an additional 2 hours. After an interval of 3 days or more, the other test food was similarly tested. The amount of increase in blood glucose level after subtracting the blood glucose level in the morning fasting and the area under the curve were evaluated. The amount of blood glucose increase and the average value of the area under the curve at each time point were calculated, and the significant difference between the control example and Example 11-1 was tested by the paired t-test, and a risk rate of 5% or less was considered significant.
Figure JPOXMLDOC01-appb-T000014
Figure JPOXMLDOC01-appb-T000014
・ベースラインからの変化
 摂取時の血糖値を基準とした、血糖上昇量を図21に示す。食後45分の血糖上昇量は、対照例が39±14mg/dLであったのに対し、実施例11-1では27±14mg/dLであり、有意に抑制された。
- Change from baseline Figure 21 shows the amount of increase in blood sugar based on the blood sugar level at the time of ingestion. The increase in blood sugar 45 minutes after eating was 39±14 mg/dL in the control example, whereas it was 27±14 mg/dL in Example 11-1, which was significantly suppressed.
・血糖値上昇曲線下面積(iAUC)
 血糖値上昇曲線下面積(iAUC)を、図22に示す。iAUCは有意に抑制された。
・Area under the blood glucose increase curve (iAUC)
The area under the blood glucose elevation curve (iAUC) is shown in FIG. iAUC was significantly suppressed.
 以上より、本発明に係る栄養組成物は、血糖値上昇を抑制できることが示された。 From the above, it was shown that the nutritional composition according to the present invention can suppress an increase in blood sugar level.
<試験例12:保存試験>
 表15に実施例12-1の組成を示す。実施例12-1は、パラチノース(イソマルツロース)、高分岐デキストリン、乳たんぱく質、難消化性デキストリン、MCT、植物油、でんぷん分解物、ラクチュロース、イヌリン、精製魚油、酵母エキス、乾燥酵母、カルニチン、乳酸菌(殺菌)、カゼインナトリウム、pH調整剤、乳化剤、塩化カリウム、香料、カラメル色素を混合する事によって調製された。なお乳化剤配合量は、0.175g/100kcalとし、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。
 実施例12-1を超高温殺菌し、125mLずつ紙パックに無菌充填した上で、常温にて6か月間静置保管した。6か月間静置保管した実施例12-1の脂肪浮上の程度を目視で確認したところ、使用上問題となるような脂肪浮上は認められず、良好な状態であった。
<Test Example 12: Storage test>
Table 15 shows the composition of Example 12-1. Example 12-1 contains palatinose (isomaltulose), highly branched dextrin, milk protein, indigestible dextrin, MCT, vegetable oil, starch hydrolyzate, lactulose, inulin, refined fish oil, yeast extract, dry yeast, carnitine, lactic acid bacteria (pasteurized), sodium caseinate, pH adjuster, emulsifier, potassium chloride, flavor, caramel coloring. The amount of the emulsifier was 0.175 g/100 kcal, and the weight ratio of lecithin and organic acid monoglyceride was 1:1.
Example 12-1 was sterilized at an ultra-high temperature, 125 mL each was aseptically filled into paper packs, and stored at room temperature for 6 months. When the degree of fat floatation of Example 12-1 that had been stored still for 6 months was visually confirmed, no fat floatation that would cause problems in use was observed, and the product was in good condition.
Figure JPOXMLDOC01-appb-T000015
Figure JPOXMLDOC01-appb-T000015
<試験例13:乳化安定性試験(中鎖脂肪酸比率の影響)>
 乳化安定性に対する中鎖脂肪酸比率による影響を調べるため、中鎖脂肪酸比率の異なるサンプルを調製し、乳化安定性を調べた。
 全構成脂肪酸中の中鎖脂肪酸の割合と、パラチノース(イソマルツロース)含有量以外は、比較例3-1と同じ条件で、表16に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例13-1の面積を1.000として算出した。
 結果を表16に示す。また、脂肪付着相対面積の評価の際の写真を図23に示す。また、脂肪付着相対面積の結果のグラフを図24に示す。
<Test Example 13: Emulsion stability test (influence of medium-chain fatty acid ratio)>
In order to investigate the effect of medium-chain fatty acid ratio on emulsion stability, samples with different medium-chain fatty acid ratios were prepared and their emulsion stability was examined.
The samples shown in Table 16 were tested in the same manner as in Test Example 1 under the same conditions as in Comparative Example 3-1 except for the proportion of medium-chain fatty acids in the total constituent fatty acids and the content of palatinose (isomaltulose). rice field. The fat deposit relative area was calculated by setting the area of Comparative Example 13-1 to 1.000.
The results are shown in Table 16. In addition, FIG. 23 shows photographs taken during the evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000016
Figure JPOXMLDOC01-appb-T000016
 いずれの評価でも、比較例13-1と比較して、中鎖脂肪酸比率の高い実施例13-1及び実施例13-2の方が、乳化安定性が良好な結果となった。特に、中鎖脂肪酸比率がより高い実施例13-2において、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が多い、パラチノース(イソマルツロース)含有量3.86g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Examples 13-1 and 13-2, which have higher medium-chain fatty acid ratios, showed better emulsification stability than Comparative Example 13-1. In particular, in Example 13-2, which has a higher medium-chain fatty acid ratio, good results in emulsion stability were obtained.
From the above, it was shown that even in a nutritional composition with a high fat content and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves the emulsion stability.
<試験例14:乳化安定性試験(中鎖脂肪酸比率の影響)>
 脂質含有量が多い条件における、乳化安定性に対する中鎖脂肪酸比率による影響を調べるため、脂質含有量が多い条件で中鎖脂肪酸比率の異なるサンプルを調製し、乳化安定性を調べた。
 脂質を含む油相と、たんぱく質及び糖質を含む水相とをそれぞれ調製し、乳化剤を添加して乳化させることによって、栄養組成物を製造した。乳化剤として、レシチンと有機酸モノグリセリドを重量比率1:1で用いた。比較例14-1、実施例14-1、実施例14-2の熱量は1.6kcal/mL、たんぱく質含有量は3.8g/100kcalとなるように調製した。
 また、比較例14-1、実施例14-1、実施例14-2の脂質の脂質エネルギー比率、脂質含有量、全構成脂肪酸中の中鎖脂肪酸の割合、糖質エネルギー比率、糖質含有量、パラチノース(イソマルツロース)含有量、乳化剤含有量は表17に示す通りである。
 表17に記載のサンプルについて、試験例1と同様の試験を行った。なお、脂肪付着相対面積は、比較例14-1の面積を1.000として算出した。
 結果を表18に示す。また、脂肪付着相対面積の評価の際の写真を図25に示す。また、脂肪付着相対面積の結果のグラフを図26に示す。
<Test Example 14: Emulsion stability test (influence of medium-chain fatty acid ratio)>
In order to investigate the effect of medium-chain fatty acid ratio on emulsion stability under conditions of high lipid content, samples with different ratios of medium-chain fatty acids were prepared under conditions of high lipid content, and the emulsion stability was examined.
A nutritional composition was produced by preparing an oil phase containing lipids and an aqueous phase containing proteins and carbohydrates, and emulsifying them by adding an emulsifier. As an emulsifier, lecithin and organic acid monoglyceride were used at a weight ratio of 1:1. Comparative Example 14-1, Example 14-1, and Example 14-2 were prepared to have a calorie of 1.6 kcal/mL and a protein content of 3.8 g/100 kcal.
Further, the lipid energy ratio, lipid content, ratio of medium-chain fatty acids in all constituent fatty acids, carbohydrate energy ratio, and carbohydrate content of the lipids of Comparative Example 14-1, Example 14-1, and Example 14-2 , palatinose (isomaltulose) content, and emulsifier content are as shown in Table 17.
The same test as in Test Example 1 was performed on the samples shown in Table 17. The fat deposit relative area was calculated by setting the area of Comparative Example 14-1 to 1.000.
The results are shown in Table 18. In addition, FIG. 25 shows a photograph of evaluation of the relative fat deposit area. Also, a graph of the results of fat deposit relative area is shown in FIG.
Figure JPOXMLDOC01-appb-T000017
Figure JPOXMLDOC01-appb-T000017
Figure JPOXMLDOC01-appb-T000018
Figure JPOXMLDOC01-appb-T000018
 いずれの評価でも、比較例14-1と比較して、中鎖脂肪酸比率の高い実施例14-1及び実施例14-2の方が、乳化安定性が良好な結果となった。特に、中鎖脂肪酸比率がより高い実施例14-2において、乳化安定性が良好な結果となった。
 以上より、脂肪含有量が6.11g/kcalと特に多い、パラチノース(イソマルツロース)含有量3.86g/100kcalの栄養組成物においても、中鎖脂肪酸比率を高くすると乳化安定性が改善することが示された。
In both evaluations, Examples 14-1 and 14-2, which have higher medium-chain fatty acid ratios, showed better emulsification stability than Comparative Example 14-1. In particular, in Example 14-2, which has a higher ratio of medium-chain fatty acids, good emulsion stability was obtained.
From the above, even in a nutritional composition with a particularly high fat content of 6.11 g/kcal and a palatinose (isomaltulose) content of 3.86 g/100 kcal, increasing the ratio of medium-chain fatty acids improves emulsion stability. It has been shown.
 本発明によれば、安定な栄養組成物を提供することができる。

 
According to the present invention, a stable nutritional composition can be provided.

Claims (10)

  1.  脂質と、糖質と、乳化剤とを含む栄養組成物であって、
     前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
     前記栄養組成物中の前記乳化剤の含有量は、0.60g/100kcal以下であり、
     前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、
     栄養組成物。
    A nutritional composition comprising a lipid, a carbohydrate, and an emulsifier,
    The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
    The content of the emulsifier in the nutritional composition is 0.60 g/100 kcal or less,
    The lipid contains medium-chain fatty acids in a proportion of 20% by mass or more in the total constituent fatty acids,
    nutritional composition.
  2.  前記糖質は、パラチノース(イソマルツロース)を含む、
     請求項1に記載の栄養組成物。
    The carbohydrate includes palatinose (isomaltulose),
    A nutritional composition according to claim 1 .
  3.  前記栄養組成物中のパラチノース(イソマルツロース)の含有量は、2g/100kcal以上である、
     請求項1又は2に記載の栄養組成物。
    The content of palatinose (isomaltulose) in the nutritional composition is 2 g/100 kcal or more,
    3. A nutritional composition according to claim 1 or 2.
  4.  前記脂質の含有量に対する前記乳化剤の含有量の比率が6.5質量%以下である、
     請求項1~3の何れか一項に記載の栄養組成物。
    The ratio of the content of the emulsifier to the content of the lipid is 6.5% by mass or less,
    A nutritional composition according to any one of claims 1-3.
  5.  前記糖質の含有量が、15g/100kcal以下である、
     請求項1~4の何れか一項に記載の栄養組成物。
    the sugar content is 15 g/100 kcal or less,
    A nutritional composition according to any one of claims 1-4.
  6.  熱量が0.6kcal/mL以上である、
     請求項1~5の何れか一項に記載の栄養組成物。
    Calorie is 0.6 kcal / mL or more,
    A nutritional composition according to any one of claims 1-5.
  7.  前記栄養組成物は、さらに、たんぱく質を含む、
     請求項1~6の何れか一項に記載の栄養組成物。
    The nutritional composition further comprises protein,
    A nutritional composition according to any one of claims 1-6.
  8.  前記乳化栄養組成物は、血糖値上昇抑制用である、
     請求項1~7の何れか一項に記載の栄養組成物。
    The emulsified nutritional composition is for suppressing elevation of blood sugar level,
    A nutritional composition according to any one of claims 1-7.
  9.  栄養組成物の乳化安定性向上方法であって、
     脂質を含む油相と、糖質を含む水相とを調製する調製工程と、
     前記油相及び前記水相を、0.60g/100kcal以下の乳化剤を添加して混合する乳化工程とを含み、
     前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
     前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、
     乳化安定性向上方法。
    A method for improving the emulsion stability of a nutritional composition, comprising:
    A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates;
    an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
    The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
    The lipid contains medium-chain fatty acids at a ratio of 20% by mass or more in the total constituent fatty acids,
    Method for improving emulsion stability.
  10.  栄養組成物の製造方法であって、
     脂質を含む油相と、糖質を含む水相とを調製する調製工程と、
     前記油相及び前記水相を、0.60g/100kcal以下の乳化剤を添加して混合する乳化工程とを含み、
     前記栄養組成物中の前記脂質の含有量は、3.5g/100kcal以上であって、
     前記脂質は、その全構成脂肪酸中に中鎖脂肪酸を20質量%以上の割合で含む、
     栄養組成物の製造方法。
     

     
    A method for producing a nutritional composition, comprising:
    A preparation step of preparing an oil phase containing lipids and an aqueous phase containing carbohydrates;
    an emulsification step of adding and mixing the oil phase and the water phase with an emulsifier of 0.60 g/100 kcal or less;
    The lipid content in the nutritional composition is 3.5 g/100 kcal or more,
    The lipid contains medium-chain fatty acids at a ratio of 20% by mass or more in the total constituent fatty acids,
    A method for producing a nutritional composition.


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WO2009096579A1 (en) * 2008-02-01 2009-08-06 Ajinomoto Co., Inc. Nutritional composition for prevention of hyperglycemia
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JP2012136471A (en) * 2010-12-27 2012-07-19 Nof Corp Nutritive composition in acidic liquid state
JP2012135257A (en) * 2010-12-27 2012-07-19 Nof Corp Liquid nutritious composition
JP2013143916A (en) * 2012-01-13 2013-07-25 Morinaga Milk Ind Co Ltd Liquid nutrient composition for patient with renal disease
JP2020127387A (en) * 2019-02-08 2020-08-27 森永乳業株式会社 Nutritive composition

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Publication number Priority date Publication date Assignee Title
JP2006050935A (en) * 2004-08-11 2006-02-23 Yaizu Suisankagaku Industry Co Ltd Emulsion-like enteral nutrient
WO2009096579A1 (en) * 2008-02-01 2009-08-06 Ajinomoto Co., Inc. Nutritional composition for prevention of hyperglycemia
WO2011118810A1 (en) * 2010-03-26 2011-09-29 味の素株式会社 Nutritional composition
JP2012136471A (en) * 2010-12-27 2012-07-19 Nof Corp Nutritive composition in acidic liquid state
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