WO2022269729A1 - Light emission device and optical guidance member holding instrument - Google Patents

Abstract

A light emission device (100) is provided with: a holding unit 31 in an arm form that has one end 31a for holding an emission end 22 of a cable-shaped optical guidance member 20, and the other end 31b, and is provided such that the position and the angle of the one end 31a are adjustable; and a base unit 32 that is provided so as to be attachable to a structure 110, and supports the other end 31b of the holding unit 31.

Description

Light irradiation device and light guide member holder

The present invention relates to a light irradiation device and a light guide member holder.

Conventionally, there has been known a light irradiation apparatus used in a treatment method in which treatment is performed by irradiating a treatment target site of a subject to which a drug containing a photosensitizer is administered with treatment light. Such a light irradiation device is disclosed, for example, in Japanese Patent Publication No. 2020-522745.

The above Japanese Patent Application Publication No. 2020-522745 discloses a medical device comprising a light source for generating laser radiation and a light guiding fiber. Medical devices are used for photodynamic therapy (PDT). Laser radiation is directed through the fiber to the treatment area.

Japanese Patent Publication No. 2020-522745

Although not disclosed in the above-mentioned Japanese National Publication of International Patent Application No. 2020-522745, in the treatment of irradiating the target site with a laser beam, a doctor grasps the vicinity of the tip of the optical fiber by hand and determines the position and orientation of the tip of the optical fiber. It was done by manual control.

In the treatment method of irradiating the treatment target area with therapeutic light, in order to obtain the desired therapeutic effect, it is necessary to precisely control the irradiation range of the treatment target area, the irradiation intensity per unit area of the treatment light, and the like. is important. The irradiation intensity per unit area depends on the distance between the output end of the optical fiber and the site to be treated. When holding a light guide member such as an optical fiber by hand, it is possible to reduce fatigue due to the work of continuously holding the light guide member in the same position for the preset irradiation time, and the blurring of the hand position while holding it. As a result, there is a problem that it is difficult to maintain the position and orientation of the output end with high accuracy. However, since a light guide member such as an optical fiber is flexible and bends easily, it is not easy to fix it in a desired position and orientation.

The present invention has been made to solve the above-described problems, and one object of the present invention is to provide a therapeutic method for irradiating a treatment target site with therapeutic light, in which the position of the exit end of the light guide member and the An object of the present invention is to provide a light irradiation device and a light guide member holder capable of maintaining the orientation with high accuracy.

In order to achieve the above object, a light irradiation device according to a first aspect of the present invention is a light irradiation device for irradiating therapeutic light onto a region to be treated of a subject to which a drug containing a photosensitizer has been administered. a cable-shaped light guide member including a light source unit for generating therapeutic light, an incident end connected to the light source unit, and an output end for outputting the light incident on the incident end; and an output end of the light guide member. an arm-shaped holding part having one end for holding and the other end opposite to the one end, the holding part being provided so that the position and angle of the one end can be adjusted; and a base portion that supports the other end of the portion.

A light guide member holder according to a second aspect of the present invention includes a cable-shaped light guide member including an emission end for irradiating therapeutic light onto a treatment target site of a subject to whom a drug containing a photosensitizer has been administered. A holder for holding a light guide member, which has one end for holding the output end of the light guide member and the other end opposite to the one end, and the position and angle of the one end are provided so as to be adjustable. and an arm-shaped holding portion, and a base portion which is provided so as to be attachable to a structure and supports the other end portion of the holding portion.

According to the present invention, as described above, the light guide member has one end that holds the output end of the light guide member and the other end that is opposite to the one end, and the position and angle of the one end are adjustable. and an arm-shaped holding portion, and a base portion that is attachable to a structure and supports the other end of the holding portion. Thereby, the base portion can be fixed to a structure existing around the subject during treatment, and the emitting end of the light guide member can be held by the arm-shaped holding portion extending from the base portion. By adjusting the position and angle of one end of the arm-shaped holding portion that holds the emission end, the position and orientation of the emission end of the light guide member can be adjusted. As a result, the position and orientation of the emission end of the light guide member can be maintained with high accuracy in the treatment method for irradiating the treatment target site with the treatment light. By adjusting the position and direction of the emission end, the irradiation range of the treatment light to the treatment target site and the distance between the treatment target site and the emission end (that is, the irradiation intensity per unit area of the treatment light) can be controlled. . As a result, it is possible to improve the treatment accuracy for obtaining the desired treatment effect.

1 is a schematic diagram of a light irradiation device according to one embodiment; FIG. It is a schematic diagram showing a light guide member. It is the perspective view which showed the structural example of the light guide member holder. FIG. 3 is an enlarged perspective view of a configuration example of a joint mechanism; FIG. 4 is a schematic perspective view of one end of the holding portion for explaining the guide portion; FIG. 4 is a perspective view showing a state in which a light guide member is held at one end; FIG. 4 is a schematic cross-sectional view for explaining the structure of the base portion shown in FIG. 3; 4 is a perspective view showing a state in which the base part shown in FIG. 3 is attached to a structure; FIG. FIG. 11 is a schematic perspective view showing a light guide member holder according to a first modified example; FIG. 10 is a schematic cross-sectional view for explaining the structure of the base portion shown in FIG. 9; FIG. 11 is a perspective view showing a state in which a light guide member is held by a light guide member holder according to a first modified example; FIG. 11 is a schematic perspective view showing a modified example of the guide portion;

An embodiment embodying the present invention will be described below based on the drawings.

The configuration of a light irradiation device 100 according to one embodiment will be described with reference to FIGS. 1 to 8. FIG.

A light irradiation device 100 shown in FIG. 1 is a light irradiation device for irradiating therapeutic light 80 onto a treatment target region 101a of a subject to whom a drug 102 containing a photosensitizer has been administered. In this embodiment, a light irradiation device 100 used for photoimmunotherapy will be described.

In photoimmunotherapy, a drug containing a fluorescent substance that causes a photochemical reaction and an antibody that selectively binds to cancer cells is administered into the body of a cancer patient, and therapeutic light in a specific wavelength band according to the fluorescent substance is administered. It is a treatment method that destroys cancer cells by irradiating them to generate a photochemical reaction.

In photoimmunotherapy, a drug 102 is administered into the body of a cancer patient 101 before treatment. Agent 102 includes a conjugate of a fluorescent substance that emits fluorescence and an antibody. The cancer patient 101 is an example of the "subject" in the claims. Also, the cancer patient 101 may be an animal other than a human being.

A fluorescent substance is a substance that causes a photochemical reaction when it is continuously irradiated with light in a specific wavelength band. In photoimmunotherapy treatment (treatment to kill cancer cells by irradiating the drug 102 containing a fluorescent substance with light of a specific wavelength band), treatment of a specific wavelength band according to the type of fluorescent substance The light 80 is irradiated to the treatment target site 101 a of the cancer patient 101 by the light irradiation device 100 . The treatment target region 101a includes, for example, the head and neck, chest, abdomen, back, internal organs (eg, digestive tract, liver, adrenal glands, etc.), but is not particularly limited.

Also, the fluorescent substance is a substance that emits fluorescence when excited by being irradiated with the therapeutic light 80 . The fluorescent substance is, for example, a chemical substance such as IRDye (registered trademark) 700DX (hereinafter referred to as "IR700"). IR700 is excited by light with a wavelength of 600 nm or more and 700 nm or less, and emits light with a wavelength of about 700 nm or 770 nm as fluorescence.

The therapeutic light 80 is light in a wavelength band in which the fluorescent substance of the drug 102 used for treatment causes a photochemical reaction. The wavelength varies depending on the type of fluorescent substance of the drug 102 used for treatment. When IR700 is used for the fluorescent substance, the therapeutic light 80 is light with a wavelength of 600 nm or more and 700 nm or less, for example, non-thermal red light (near infrared light) with a wavelength of about 690 nm.

Antibodies contained in the drug 102 selectively bind to cancer cell antigens (specific proteins expressed in cancer cells). Antibodies are therefore selected to match antigens of cancer cells to be treated. Antibodies are, for example, cetuximab and the like.

The drug 102 administered to the cancer patient 101 circulates through the body of the cancer patient 101 through the bloodstream, and selectively binds to antigens of cancer cells present in the treatment target site 101a by means of antibodies. The fluorescent substance of the drug 102 absorbs the therapeutic light 80 irradiated to the treatment target region 101a, thereby causing a photochemical reaction and changing the chemical structure of the fluorescent substance. This change in the chemical structure of the fluorescent substance causes a change in the three-dimensional structure of the antibody. Then, the conformational change of the antibody bound to the cancer cells damages the cell membrane of the bound cancer cells. As a result, the cancer cells swell and rupture due to the water that has entered through the damaged cell membrane of the cancer cells, thereby destroying (destroying) the cancer cells. A fluorescent substance does not emit fluorescence after undergoing a change in chemical structure due to a photochemical reaction.

In this embodiment, in particular, near infrared photoimmunotherapy (NIR- PIT), but the photoimmunotherapy is not limited to this.

(Configuration of light irradiation device)
As shown in FIG. 1, the light irradiation device 100 is configured to output therapeutic light 80 in a specific wavelength band according to the fluorescent substance contained in the drug 102 used for photoimmunotherapy. The light irradiation device 100 includes a light source section 10 , a light guide member 20 and a light guide member holder 30 . The light guide member holder 30 includes a holding portion 31 that holds the output end 22 of the light guide member 20 and a base portion 32 that supports the holding portion 31 . The light irradiation device 100 further includes a control section 15 and an input operation section 16 .

The light source unit 10 generates therapeutic light 80. The light source unit 10 emits the generated therapeutic light 80 to the light guide member 20 .

The light source section 10 includes at least one light source unit 11 . One light source unit 11 has one light output port 12 . Accordingly, the light source section 10 includes at least one light output port 12 to which the light guide member 20 is connected. The light source unit 10 is configured to be able to emit therapeutic light 80 from the light output port 12 . In the example of FIG. 1 , the light source section 10 includes four light source units 11 . Accordingly, the light source section 10 includes four light output ports 12 .

The therapeutic light 80 is light of a predetermined wavelength included in the absorption wavelength band of the fluorescent substance contained in the drug 102 administered into the body of the cancer patient 101 .

The light output port 12 is an exit port for the therapeutic light 80 and a connection port for the light guide member 20 . One light guide member 20 is connected to one light output port 12 . The number of optical output ports 12 may be one or more. Each of the multiple light output ports 12 is configured to emit therapeutic light 80 to the incident end 21 of the light guide member 20 connected to that light output port 12 .

Each light source unit 11 includes a light source 13 that emits therapeutic light 80 . A plurality (four) of light source units 11 can emit therapeutic light 80 independently of each other. In this way, the light source unit 10 can individually switch between emitting and stopping the therapeutic light 80 from each of the plurality of light output ports 12 .

The light guide member 20 has a function of guiding the light emitted from the light output port 12 to the treatment target site 101a by being connected to one of the light output ports 12 of the light source section 10 . A plurality of light guide members 20 are cable-like members that are connected to the plurality of light output ports 12 one by one. The light guide member 20 is a disposable consumable item. The maximum number of light guide members 20 that can be simultaneously connected to the light source section 10 is the number of light output ports 12 . The number of light output ports 12 (that is, the number of light guide members 20) to be used simultaneously is determined according to the content of treatment. FIG. 1 shows only one light guide member 20 for convenience.

The light guide member 20 includes an incident end 21 connected to the light source section 10 and an emitting end 22 for emitting light incident on the incident end 21 . The input end 21 and the output end 22 are connected by an optical fiber cable 23 . Input end 21 includes an attachment for connecting to optical output port 12 . The output end 22 is configured by a light diffusing member (light diffuser). As shown in FIG. 2, the output end 22 directs the light forward perpendicularly to the end surface of the output end 22 and diffuses the light at a predetermined irradiation angle, thereby forming a cone beam (or a polygonal pyramid). It is a forward emitting light diffuser that emits light.

As shown in FIG. 1, the forward emission type light guide member 20 is used for irradiating the therapeutic light 80 from outside the body of the cancer patient 101 toward the body surface. In photoimmunotherapy, in order to obtain the desired therapeutic effect, the irradiation range of the therapeutic light 80 to the treatment target region 101a (hatched part in FIG. 1), the irradiation intensity per unit area of the therapeutic light 80, etc. are controlled with high accuracy. It is important to. The irradiation range of the therapeutic light 80 irradiated from the emission end 22 to the treatment target region 101a depends on the distance between the emission end 22 and the treatment target region 101a and the angle of the optical axis of the emission end 22 with respect to the treatment target region 101a (that is, , the orientation of the exit end 22). The irradiation intensity per unit area in the treatment target region 101a depends on the emission intensity of the therapeutic light 80 from the emission end 22 and the distance between the emission end 22 and the treatment target region 101a.

Therefore, it is important to accurately set the position and orientation of the emission end 22 with respect to the treatment target region 101a and to maintain the position and orientation of the emission end 22 during treatment (while the therapeutic light 80 is being output). . In this embodiment, the light guide member holder 30 adjusts and maintains the position and orientation of the output end 22 .

As shown in FIG. 1, the control unit 15 is a computer configured to control the light source unit 10. The control unit 15 controls the light source unit 10 to emit therapeutic light 80 from the emission end 22 of the light guide member 20 during photoimmunotherapy treatment. The control unit 15 individually controls the plurality of light source units 11 to start and stop the irradiation of the therapeutic light 80 for each of the plurality of light output ports 12 (the ON/OFF switching of irradiation) can be individually controlled.

The control unit 15 is composed of a computer including a processor and a storage unit. The processor is configured by, for example, a CPU (Central Processing Unit). The storage includes, for example, volatile memory and non-volatile memory such as flash memory or hard disk drives. The storage unit stores a program for causing the processor to function as the control unit 15 of the light irradiation device 100 and various setting information for light irradiation.

The input operation unit 16 is connected to the control unit 15 and configured to receive operation inputs for starting and stopping the irradiation of the therapeutic light 80 . The input operation unit 16 is configured by an input device such as a foot switch or hand switch. The control unit 15 outputs therapeutic light 80 from the light output port 12 in accordance with an operation input received via the input operation unit 16 .

The number of optical output ports 12 used for photoimmunotherapy is preset in the control unit 15 by a doctor or the like according to the content of treatment for the cancer patient 101 . Specifically, the irradiation conditions of the therapeutic light 80 are preset in the control unit 15 as setting information. The irradiation conditions of the therapeutic light 80 can include setting information such as the irradiation time of the therapeutic light 80, the total energy amount of the therapeutic light 80, the output intensity of the therapeutic light 80, and the like. The total energy amount is the sum of the energy of the therapeutic light 80 by irradiating the treatment target region 101a with the therapeutic light 80 having the set output intensity during the set treatment time, and is the energy amount per unit area ( J/cm). In photoimmunotherapy, the therapeutic effect is controlled by setting the amount of energy per unit area of the treatment target region 101a to a desired value.

The light guide member holder 30 is a cable-shaped guide including an emission end 22 for irradiating a treatment target region 101a of a subject (cancer patient 101) to which a drug 102 containing a photosensitizer is administered with therapeutic light 80. A holder that holds the optical member 20 .

The light guide member holder 30 includes an arm-shaped holding portion 31 having one end portion 31a for holding the output end 22 of the light guide member 20 and the other end portion 31b opposite to the one end portion 31a. The holding portion 31 is provided so that the position and angle of the one end portion 31a can be adjusted. The holding portion 31 preferably includes a joint mechanism 40 between the one end portion 31a and the other end portion 31b, and the position and angle of the one end portion 31a can be adjusted by the joint mechanism 40. As shown in FIG. One or a plurality of holding portions 31 are provided.

The light guide member holder 30 has a base portion 32 that supports the other end portion 31 b of the holding portion 31 . The base portion 32 is provided so as to be attachable to the structure 110 . Base portion 32 is configured to support one or more retaining portions 31 .

The structure 110 is not particularly limited as long as it is a structure existing at the treatment site where the cancer patient 101 is treated. The structure 110 can be, for example, a member that supports various instruments used for treatment, such as a support bar or an installation table attached to the bed 120 on which the cancer patient 101 is placed. The structure 110 may be a stand member or the like for attaching an IV bag. The structure 110 may be a supporting member of equipment used for treatment together with the light irradiation device 100 . A device used for treatment together with the light irradiation device 100 is, for example, a fluorescence imaging device 200 (see FIG. 11), which will be described later. The base section 32 may use a support mechanism 210 (see FIG. 11) for supporting the fluorescence imaging device 200 as the structure 110 .

(Light guide member holder)
Next, a detailed configuration of the light guide member holder 30 will be described. FIG. 3 shows an example of a configuration in which a plurality (two) of holding portions 31 are individually attached to one base portion 32 .

(Holding part)
As shown in FIG. 3, the holding portion 31 includes a plurality of joint mechanisms 40 connected in series between one end portion 31a and the other end portion 31b. In the example of FIG. 3 , one holding portion 31 includes three joint mechanisms 40 . The three joint mechanisms 40 have the same configuration. When distinguishing the three joint mechanisms 40, the joint mechanisms 40a, 40b, and 40c are used in order from the other end portion 31b side to the one end portion 31a side.

Each joint mechanism 40 includes a rod-shaped link 41 and a joint 42 that rotatably holds the link 41 . The link 41 is a rod-shaped member extending linearly with a predetermined length. As shown in FIG. 4 , connecting portions 41 a to joints 42 are formed at both ends of the link 41 . The connecting portion 41 a has a shape that matches the structure of the joint 42 . The link 41 has sufficient rigidity to prevent bending deformation under normal use conditions. Each part (link 41, joint 42, etc.) that constitutes the joint mechanism 40 is preferably made of a metal material that can be sterilized. Metal materials that can be sterilized are, for example, stainless steel, aluminum (or aluminum alloy), and the like.

The joint 42 rotatably connects one link 41 on the one end 31a side and the other link 41 on the other end 31b side. Accordingly, the joint 42 has a pair of receiving portions that rotatably hold the connecting portion 41a of the link 41, respectively. The joint 42 is configured such that the rotation angle of the link 41 can be adjusted by an external force applied by the user, and the adjusted angle of the link 41 can be maintained. That is, the torque required to rotate the link 41 is greater than the torque that naturally acts on the joint 42 due to the action of gravity.

As shown in FIG. 4, the joint 42 is configured by a spherical joint. In the example of FIG. 4, the joint 42 includes a pair of retaining plates 43a and 43b and a fastening member 45 that fastens the pair of retaining plates 43a and 43b.

Each of the pair of holding plates 43a and 43b has a recess 44 that receives a portion of the connecting portion 41a of the link 41. The recessed portion 44 is a through hole penetrating the holding plate 43a or 43b in the thickness direction, but may be a non-penetrating recessed portion. Two recesses 44 are formed in each of the holding plates 43a and 43b, one at each end in the long side direction. The pair of holding plates 43a and 43b are arranged such that the two concave portions 44 at both ends face each other.

A set of concave portions 44 facing each other on one end side constitutes one receiving portion, and another set of concave portions 44 facing each other on the other end side constitutes another receiving portion. The connecting portion 41 a of the link 41 engages with the receiving portion formed by the pair of recesses 44 .

Specifically, the connecting portion 41a of the link 41 is arranged between the pair of holding plates 43a and 43b. The connecting portion 41a has a spherical shape. A portion of the spherical connection portion 41a is arranged in the recess 44 of the holding plate 43a, and the other portion of the connection portion 41a is arranged in the recess 44 of the holding plate 43b. As a result, the connecting portion 41a of the link 41 is sandwiched between the pair of holding plates 43a and 43b in a state of being fitted in the pair of recesses 44 of the pair of holding plates 43a and 43b. As a result, the connecting portion 41a is rotatably engaged with the pair of holding plates 43a and 43b in a pair of opposed recesses 44 (receiving portions). As a result, the joint 42 holds the connecting portion 41a rotatably in any direction. Similarly, connecting portions 41a of other links 41 are arranged in the other pair of recesses 44 (receiving portions) of the pair of holding plates 43a and 43b.

The joint 42 allows the link 41 (connecting portion 41a) to rotate about the connecting portion 41a in a direction along the surfaces of the pair of holding plates 43a and 43b. The joint 42 allows the link 41 to rotate about the connecting portion 41a in the direction in which the pair of holding plates 43a and 43b face each other. The joint 42 allows the link 41 to rotate about the central axis of the link 41 .

The fastening member 45 fastens the pair of holding plates 43a and 43b in a direction toward each other. That is, the fastening member 45 presses the pair of holding plates 43a and 43b toward the connecting portion 41a.

Specifically, the fastening member 45 includes a bolt 45a and a nut 45b. A through-hole (not shown) for passing the shaft portion of the bolt 45a is formed in the central portion (between the concave portion 44 at one end and the concave portion 44 at the other end) of each of the holding plates 43a and 43b.

A pair of holding plates 43a and 43b are joined together by bolts 45a passing through the through holes of the holding plates 43a and 43b. A pair of holding plates 43a and 43b are connected to each other by bolts 45a and nuts 45b and are tightened from both outsides.

By adjusting the tightening amount of the fastening member 45, the magnitude of the torque required to rotate the connecting portion 41a can be adjusted. The fastening member 45 fixes the link 41 to the joint 42 so that the link 41 does not naturally rotate after positioning the link 41 so that the link 41 faces a desired rotation angle.

<Deformable member>
As shown in FIG. 3, in the present embodiment, the holding portion 31 has a deformable member 50 that can be bent and deformed by an external force and that can maintain its shape. The deformable member 50 constitutes one end portion 31 a of the holding portion 31 . That is, the deformable member 50 is arranged in the holding portion 31 closest to the one end portion 31a. 3, the joint mechanism 40a (first set of joints 42 and link 41), the joint mechanism 40b (second set of joints 42 and link 41), joint mechanism 40c (third set of joint 42 and link 41), and deformable member 50 are arranged in this order. The deformable member 50 is connected to the end (connecting portion 41a) of the link 41 of the joint mechanism 40c. The tip of the deformable member 50 is one end 31 a of the holding portion 31 .

The deformable member 50 is a wire-shaped member. The deformable member 50 is made of metal. The metal forming the deformable member 50 is, for example, stainless steel, aluminum (or aluminum alloy), or the like. The deformable member 50 has a larger diameter (outer diameter) than the optical fiber cable 23 of the light guide member 20, for example. The deformable member 50 can be bent into any shape by applying an external force manually by the user. The deformable member 50 maintains its bent shape due to the stiffness of the deformable member 50 itself. Unlike the link 41, the deformable member 50 is freely bendable, allowing the user to freely adjust the position, orientation, and path to the one end 31a.

<Guide part>
As shown in FIG. 5 , in this embodiment, the holding portion 31 has a guide portion 55 that guides the light guide member 20 . As shown in FIG. 6, the guide portion 55 guides the light guide member 20 along the direction in which the one end portion 31a extends. The direction in which the one end portion 31a extends is the direction in which the center axis 31e of the rod-shaped one end portion 31a extends. The guide portion 55 guides the light guide member 20 so that the direction of the output end 22 of the light guide member 20 (optical axis direction from the output end 22) is along the direction in which the one end portion 31a extends.

Returning to FIG. 5 , the guide portion 55 is provided at one end portion 31 a of the holding portion 31 . The guide portion 55 is a groove or projection (see FIG. 12) formed on the outer surface of the one end portion 31a. In the example of FIG. 5, the guide portion 55 is a groove. The one end portion 31a is configured by a round bar-shaped tip member. A V-shaped groove forming a guide portion 55 is formed on the outer surface of the one end portion 31a.

The guide portion 55 has a guide surface 55a on which part of the light guide member 20 (see FIG. 6) can be arranged. That is, the outer peripheral surface of the light guide member 20 contacts the guide surface 55a. The light guide member 20 is directed by the guide surface 55a. In the groove-shaped guide portion 55, the inner surface of the groove is the guide surface 55a. That is, the guide portion 55 has a pair of V-shaped guide surfaces 55a.

As shown in FIG. 6, the light guide member 20 is arranged so as to fit inside the groove-shaped guide portion 55 at the one end portion 31a. The light guide member 20 is guided along the guide portion 55 by the contact of the outer peripheral surface of the light guide member 20 with the pair of guide surfaces 55a. In this state, the light guide member 20 is fixed to the one end portion 31a.

In the examples of FIGS. 5 and 6, the holding portion 31 has a ring-shaped fixing member 56. As shown in FIG. The inner diameter of the fixing member 56 is the same as or slightly larger than the outer diameter of the rod-shaped one end portion 31a. The light guide member 20 is held at the one end portion 31a by arranging the one end portion 31a in which the light guide member 20 is fitted in the guide portion 55 inside the fixing member 56 . The fixing member 56 is made of an elastically deformable resin material such as silicon rubber. The fixing member 56 bundles the one end portion 31a and the light guide member 20 and holds the light guide member 20 while biasing it toward the guide surface 55a.

Thereby, as shown in FIG. 6, the direction of the one end 31a of the holding portion 31 (the center axis 31e of the one end 31a) and the direction of the emission end 22 of the light guide member 20 match. Therefore, by directing the one end portion 31a toward the treatment target site 101a, the emission direction of the therapeutic light 80 emitted from the emission end 22 can be accurately directed to the treatment target site 101a.

<Number and types of holding parts>
Here, in the example of FIG. 3 , a plurality of holding portions 31 can be provided on the base portion 32 . In this embodiment, the holding portion 31 includes a first holding portion 31-1 having a first length L1, a second holding portion 31-2 having a second length L2 greater than the first length L1, including. In this specification, the "first length" and the "second length" are the total length of the holding portion 31, and specifically, the path length from the other end portion 31b to the one end portion 31a (each joint mechanism 40a to 40c and the length of deformable member 50).

The lengths of the first holding portion 31-1 and the second holding portion 31-2 are different due to, for example, at least one of the number of joint mechanisms 40 and the dimensions of the constituent members being different. FIG. 3 shows an example in which the number of joint mechanisms 40 is the same in the first holding portion 31-1 and the second holding portion 31-2, but the dimensions of the link 41 of the first joint mechanism 40a are different. showing. The length of the link 41 of the first pair (joint mechanism 40a) of the second holding portion 31-2 is longer than the length of the link 41 of the first pair (joint mechanism 40a) of the first holding portion 31-1. Thereby, the second length L2 is larger than the first length L1.

As a method of varying the length of the holding portion 31, for example, the number of joint mechanisms 40 forming the holding portion 31 may be varied. For example, the lengths of the deformable members 50 forming the holding portion 31 may be varied. For example, the lengths of the holding portions 31 may be varied by not providing the deformable member 50 to the first holding portion 31-1 and providing the deformable member 50 to the second holding portion 31-2. A plurality of holding portions 31 having the same length may be provided.

In this embodiment, since the joint 42 is composed of a pair of holding plates 43a and 43b (see FIG. 4) and the fastening member 45, the joint mechanism 40 can be disassembled and assembled. Therefore, the holding portion 31 is configured such that the number of the joint mechanisms 40 can be changed by disassembling and assembling. Further, the length of the holding portion 31 can be freely set by replacing a plurality of types of links 41 (see FIG. 3) having different lengths. Even if the weight acting on the joints 42 is changed by changing the number of the joint mechanisms 40, the fastening force of the fastening members 45 at the joints 42 (rotational required torque) can be adjusted.

<Base part>
As shown in FIG. 3, the base portion 32 includes a body portion 32a that can be attached to and detached from the structure 110. As shown in FIG. In the example of FIG. 3 , the base portion 32 can hold a plurality of holding portions 31 . The base portion 32 is configured to detachably hold each holding portion 31 . That is, the number of holders 31 corresponding to the number of light guide members 20 to be used can be attached to the base portion 32 , and unused holders 31 can be removed from the base portion 32 .

The base portion 32 includes a plurality of mounting portions 32b to which the holding portion 31 can be attached and detached. Each of the plurality of attachment portions 32b receives and supports one holding portion 31. As shown in FIG. Specifically, the attachment portion 32b is configured by a screw hole formed in the body portion 32a. FIG. 3 illustrates a situation in which four mounting portions 32b are formed on the main body portion 32a, and the holding portion 31 is mounted to each of two of the mounting portions 32b.

As shown in FIG. 7, the other end portion 31b of the holding portion 31 is configured by an attachment for attaching the holding portion 31 to the base portion 32. As shown in FIG. The other end portion 31 b has a connection portion 31 c having the same shape as the connection portion 41 a of the link 41 of the holding portion 31 and a screw portion (male screw) 31 d attached to the attachment portion 32 b of the base portion 32 . The connecting portion 31c of the other end portion 31b is connected to the receiving portion of the joint 42 of the first pair. The threaded portion 31d engages with the mounting portion 32b, which is a screw hole (female screw). The holding portion 31 is attached to the base portion 32 by fastening the screw portion 31d and the attachment portion 32b. The holding portion 31 can be removed from the base portion 32 by releasing the fastening between the screw portion 31d and the mounting portion 32b.

Next, a structure for attaching the base portion 32 to the structure 110 will be described.

FIG. 7 shows an example of a body portion 32a that can be attached to a columnar structure 110. FIG. Specifically, in the example of FIG. 7, the body portion 32a is divided into two blocks 60a and 60b, and the structure 110 is sandwiched between the two blocks 60a and 60b. The two blocks 60a, 60b are connected to each other by bolts 61. As shown in FIG.

The base portion 32 has a contact surface 32c that can come into contact with the structure 110. That is, concave contact surfaces 32c (concave portions) for inserting the structure 110 are formed on respective coupling surfaces (surfaces facing each other) of the two blocks 60a and 60b. A through hole 62 penetrating through the body portion 32a is formed by the contact surface 32c of each of the blocks 60a and 60b. A columnar structure 110 is arranged so as to pass through the through hole 62 .

In the example of FIG. 8, the structure 110 is a support bar attached to the bed 120 on which the cancer patient 101 is placed. The support bar includes first portion 121 and second portion 122 . The first portion 121 rises upward from the lower portion of the bed 120 , passes through the sides of the bed 120 and extends to a position above the bed 120 . The second portion 122 extends horizontally from the upper end of the first portion 121 so as to cross over the bed 120 . The body portion 32a of the base portion 32 is attached to the second portion 122 of this support bar. A second portion 122 of the support bar, which is the structure 110, is inserted through the through hole 62 (see FIG. 7) of the main body portion 32a.

As shown in FIG. 7, the concave contact surface 32c of the block 60a and the concave contact surface 32c of the block 60b can each come into contact with the structure 110 (second portion 122).

In addition, the base portion 32 includes an operation portion 65 for performing a switching operation to fix or release the fixation of the base portion 32 to the structure 110 . The operating portion 65 switches the state of the base portion 32 between a fixed state in which the contact surface 32c is fixed to the structure 110 by pressing the contact surface 32c against the structure 110 and a released state in which the pressing is released.

The operating portion 65 includes a lever 66 and a pressing portion 67 that can advance and retreat toward the through hole 62 according to the operation of the lever 66 . The lever 66 is rotatably provided on the main body 32a and can be operated by a user's hand. The pressing portion 67 is, for example, a screw member arranged in a hole penetrating from the outside of the body portion 32 a to the inside of the through hole 62 . The pressing portion 67 is connected to the lever 66 and has its tip directed toward the interior of the through hole 62 . The pressing portion 67 meshes with, for example, a thread groove (female screw) formed in the main body portion 32a, and advances and retreats toward the through hole 62 as the lever 66 rotates.

When the lever 66 is rotated in the forward direction, the pressing portion 67 advances toward the through hole 62 and presses the structure 110 inside the through hole 62 . As a result, the contact surface 32 c of the body portion 32 a is pressed against the structure 110 . As a result, the base portion 32 is fixed.

When the lever 66 is rotated in the opposite direction, the pressing portion 67 moves away from the through hole 62 and releases the pressure on the structure 110 inside the through hole 62 . As a result, the base portion 32 is in the released state. Since the pressing force ceases to act, the base portion 32 becomes movable with respect to the structure 110 .

The light guide member holder 30 of this embodiment is configured as described above.

(Flow of treatment by light irradiation device)
Next, an example of the flow of treatment by the light irradiation device 100 will be described.

First, the light guide member holder 30 is prepared. Since the number of light guide members 20 to be used is determined according to the treatment plan, the same number of holders 31 as the number of light guide members 20 are attached to the base portion 32 .

At this time, as shown in FIG. 8, the relative position between the mounting position of the base portion 32 with respect to the structure 110 and the treatment target portion 101a (see FIG. 1) of the patient 101, the presence or absence of obstacles, and the like are taken into consideration. Thus, the length of the holding portion 31 to be attached to the base portion 32 is determined. A holding portion 31 corresponding to the determined length is attached to the base portion 32 . Either the first holding portion 31-1 or the second holding portion 31-2 is selected as the holding portion 31 to be attached. Further, in this embodiment, since the holding portion 31 can be disassembled and assembled, the holding portion 31 whose length is appropriately adjusted is attached to the base portion 32 .

When the required number of holding parts 31 are attached to the base part 32 , the base part 32 is attached to the structure 110 . The user switches the base portion 32 from the open state to the fixed state by operating the operation portion 65 . The base portion 32 is thereby fixed to the structure 110 . Note that the holding portion 31 may be attached to the base portion 32 after the base portion 32 is fixed to the structure 110 .

Next, as shown in FIG. 6 , the user holds the output end 22 of the light guide member 20 on the one end 31 a of the holding portion 31 . The light guide member 20 is guided by the guide portion 55 so that the output end 22 is oriented in the direction in which the one end portion 31a extends.

Although illustration of the light guide member 20 is omitted in FIG. 8, the positions and orientations of the one end portions 31a are set by adjusting the joint mechanisms 40 and the deformable members 50 of the respective holding portions 31. . As a result, the output end 22 of each light guide member 20 held by each holding portion 31 is accurately arranged at the planned irradiation position toward the treatment target region 101a. Each holding portion 31 maintains the set position and orientation of one end portion 31a.

As a result, preparations for irradiation with the therapeutic light 80 are completed. The doctor operates the light irradiation device 100 by performing an input operation on the input operation unit 16, as shown in FIG. The control unit 15 controls the light source unit 10 to emit the therapeutic light 80 according to a signal from the input operation unit 16 . As a result, the therapeutic light 80 is emitted from the emission end 22 of each light guide member 20 held by each holding portion 31 to the treatment target region 101a. During treatment, the doctor does not need to hold the output end 22 of the light guide member 20 by hand. When the preset irradiation time elapses, the irradiation of the therapeutic light 80 is stopped. Thereby, the irradiation of the therapeutic light 80 ends.

(Effect of this embodiment)
The following effects can be obtained in this embodiment.

That is, the light irradiation device 100 of the present embodiment is used for irradiating the treatment target region 101a of the subject (cancer patient 101) to whom the drug 102 containing a photosensitizer is administered with the therapeutic light 80 as described above. A light irradiation device 100, which is a cable-like cable including a light source unit 10 that generates therapeutic light 80, an incident end 21 connected to the light source unit 10, and an output end 22 that outputs the light incident on the incident end 21 It has a light guide member 20, one end portion 31a holding the output end 22 of the light guide member 20, and the other end portion 31b opposite to the one end portion 31a, and the position and angle of the one end portion 31a are provided so as to be adjustable. and a base portion 32 that is attachable to the structure 110 and supports the other end portion 31 b of the holding portion 31 .

Further, the light guide member holder 30 of the present embodiment has an emission end 22 for irradiating the treatment target region 101a of the subject (cancer patient 101) to whom the drug 102 containing a photosensitizer is administered with the therapeutic light 80. A light guide member holder 30 that holds a cable-shaped light guide member 20 including and an arm-shaped holding portion 31 provided so that the position and angle of one end portion 31a can be adjusted, and a base portion 32 provided so as to be attachable to the structure 110 and supporting the other end portion 31b of the holding portion 31. And prepare.

With the above configuration, the base portion 32 is fixed to the structure 110 existing around the subject (cancer patient 101 ) during treatment, and the light emitting end of the light guide member 20 is held by the arm-shaped holding portion 31 extending from the base portion 32 . 22 can be held. By adjusting the position and angle of one end portion 31 a that holds the output end 22 in the arm-shaped holding portion 31 , the position and orientation of the output end 22 of the light guide member 20 can be adjusted. As a result, the position and orientation of the emission end 22 of the light guide member 20 can be maintained with high accuracy in the treatment method for irradiating the treatment target site 101a with the treatment light 80. FIG. By adjusting the position and orientation of the output end 22, the irradiation range of the therapeutic light 80 to the treatment target site 101a and the distance between the treatment target site 101a and the output end 22 (that is, the unit area of the therapeutic light 80 irradiation intensity) can be controlled. As a result, it is possible to improve the treatment accuracy for obtaining the desired treatment effect.

In addition, in the above embodiment, further effects can be obtained by configuring as follows.

Specifically, in this embodiment, the holding portion 31 includes a plurality of joint mechanisms 40 connected in series between the one end portion 31a and the other end portion 31b. With this configuration, the position and orientation of the one end portion 31 a holding the output end 22 of the light guide member 20 can be adjusted by each of the plurality of joint mechanisms 40 . As the number of joint mechanisms 40 increases, the degree of freedom of posture of the holding portion 31 from the other end portion 31b to the one end portion 31a increases. Therefore, even if there are obstacles (such as medical equipment) around the patient, the plurality of joint mechanisms 40 connected in series allows the output end 22 to be arranged at a desired position and orientation while avoiding the obstacles.

Also, in this embodiment, the joint mechanism 40 includes a rod-shaped link 41 and a joint 42 that rotatably holds the link 41 . By configuring in this way, each joint mechanism 40 of the holding portion 31 can be configured with a simple and lightweight structure.

Also, in this embodiment, the joint 42 is configured by a spherical joint. With this configuration, the rotation direction of the joint 42 is not restricted, so that the link 41 can be rotated in any direction in each joint mechanism 40 . Therefore, it is possible to effectively increase the flexibility of the posture of the holding portion 31 from the other end portion 31b to the one end portion 31a.

Also, in this embodiment, the one end 31a has a rod-like shape, and the holding portion 31 has a guide portion 55 that guides the light guide member 20 along the direction in which the one end 31a extends. With this configuration, the direction of the output end 22 of the light guide member 20 can be aligned with the direction in which the one end portion 31a of the holding portion 31 extends (the axial direction of the one end portion 31a). Therefore, even with the flexible cable-shaped light guide member 20, the emission direction of the therapeutic light 80 from the emission end 22 can be adjusted with high accuracy.

Further, in this embodiment, the guide portion 55 is a groove or protrusion formed on the outer surface of the one end portion 31a, and has a guide surface 55a on which a part of the light guide member 20 can be arranged. With this configuration, by bringing the light guide member 20 into contact with the guide surface 55a of the guide portion 55, the direction of the output end 22 can be easily and accurately matched with the direction in which the one end portion 31a of the holding portion 31 extends. be able to.

In addition, in this embodiment, the holding portion 31 has a deformable member 50 that can be bent and deformed by an external force and that can maintain its shape. With this configuration, by bending the deformable member 50, the position and orientation of the one end portion 31a can be arbitrarily adjusted. Since the light guide member 20 is an extremely lightweight cable-like member, the adjusted deformable member 50 can be adjusted by using the deformable member 50 having rigidity sufficient to support the weight of the tip of the light guide member 20. The light guide member 20 can be held by the one end portion 31a of the tip of the deformable member 50 without changing the shape of the deformable member 50 . Thereby, the position and orientation of the output end 22 of the light guide member 20 can be adjusted very freely.

Further, in this embodiment, the light source section 10 includes a plurality of light output ports 12 to which the light guide member 20 can be connected, and the base section 32 includes a plurality of attachment sections 32b to which the holding section 31 can be attached and detached. . With this configuration, in a configuration in which the therapeutic light 80 can be emitted from each of the plurality of light guide members 20, it is possible to attach the plurality of holding portions 31 to the base portion 32 in accordance with the number of the light guide members 20 to be used. can. When the number of light guide members 20 is reduced, the unused holding portions 31 can be removed from the base portion 32, so that the unused holding portions 31 can be prevented from interfering with treatment. As a result, it is possible to obtain a high level of convenience that can be handled when the number of light guide members 20 used for treatment changes according to the content of treatment.

Further, in this embodiment, the holding portion 31 includes a first holding portion 31-1 having a first length L1 and a second holding portion 31-2 having a second length L2 longer than the first length L1. and including. With this configuration, it is possible to selectively use holding portions 31 having different lengths according to the distance from the base portion 32 to the position where the emission end 22 is arranged (the emission position of the therapeutic light 80). For example, a first holding portion 31-1 having a short length is used at an irradiation position closer to the base portion 32, and a second holding portion 31-2 having a longer length is used at an irradiation position farther from the base portion 32. By using it, it is possible to prevent the holding part 31 from occupying the space unnecessarily due to the extra length. Therefore, the holding part 31 does not interfere with the work of the medical staff. In addition, when there is an obstacle between the base portion 32 and the position where the output end 22 is arranged, by using the second holding portion 31-2 having a large length, it is possible to avoid the obstacle and obtain an appropriate position. The output end 22 can be held at These can improve the workability of treatment.

Further, in the present embodiment, the base portion 32 has a contact surface 32c that can contact the structure 110, a fixed state in which the contact surface 32c is fixed to the structure 110 by pressing the contact surface 32c against the structure 110, It includes an operation unit 65 that switches to a released state in which the pressing is released. With this configuration, the fixing and unfixing of the base portion 32 to the structure 110 can be easily performed by the operating portion 65 . As a result, it is possible to effectively improve the workability in preparation for treatment and in work after completion of treatment.

[Variation]
It should be noted that the embodiments disclosed this time should be considered as examples and not restrictive in all respects. The scope of the present invention is indicated by the scope of the claims rather than the above-described description of the embodiments, and includes all modifications (modifications) within the meaning and scope equivalent to the scope of the claims.

(First modification)
FIG. 9 shows a first modification of this embodiment. The base portion 132 according to the first modification differs from the base portion 32 (see FIG. 3) of the above-described embodiment in structure and attached structure 110 . In the example of FIG. 9, the structure 110 to which the base portion 132 is attached is a support mechanism 210 for supporting the fluorescence imaging device 200 (see FIG. 11). The support mechanism 210 has a beam-like structure with a rectangular cross section and movably holds the fluorescence imaging device 200 .

In the example of FIG. 9, the base part 132 is configured to be attachable to and detachable from the structure 110 via the covering sheet 105. The covering sheet 105 is a sterile medical drape. The base portion 132 has a contact surface 32c (see FIG. 10) that can come into contact with the structure 110 (support mechanism 210) through the cover sheet 105. As shown in FIG. The base portion 132 includes a pressing member 134 that presses the contact surface 32 c against the structure 110 .

As shown in FIG. 10, the outer peripheral surface of a structure 110 with a rectangular cross section is covered with a cover sheet 105. The base portion 132 includes three flat plate portions 133a, 133b, 133c along the upper surface and a pair of side surfaces of the structure 110, respectively. The inner surfaces of these flat plate portions 133a, 133b, 133c are contact surfaces 32c. The contact surface 32c faces the structure 110 (support mechanism 210) with the cover sheet 105 interposed therebetween. A pressing member 134 is provided at the lower ends of the pair of flat plate portions 133a and 133c. The pressing member 134 urges the lower ends of the pair of flat plate portions 133a and 133c in a direction to approach each other. In FIG. 10, the pressing member 134 is a stretchable belt-shaped member. The pressing member 134 may be a fastening member made up of bolts and nuts. The biasing force of the pressing member 134 presses the contact surface 32 c against the structure 110 via the cover sheet 105 , thereby fixing the base portion 132 to the structure 110 .

In the first modified example, the base portion 132 has a contact surface 32c that can contact the structure 110 via the cover sheet 105, so that large structures that are difficult to sterilize or structures that are fixedly installed indoors etc. The base portion 132 can also be attached to the .

As shown in FIG. 11 , the fluorescence imaging device 200 is arranged so that the lens unit 201 faces the treatment target region 101a of the cancer patient 101 . In FIG. 11, illustration of a portion for supporting the fluorescence imaging device 200 by the support mechanism 210 is omitted. In photoimmunotherapy, a fluorescent substance (IR700) contained in the drug 102 is excited by the therapeutic light 80 and emits fluorescence with a wavelength different from that of the therapeutic light 80 . The fluorescence imaging device 200 detects fluorescence emitted from the treatment target site 101a and generates a fluorescence image. Fluorescent images can be used to monitor the progress of treatment.

Since both the fluorescence imaging device 200 and the light guide member 20 are arranged facing the treatment target region 101a, they may become obstacles to each other. In this first modification, a plurality of holding portions 31 (a first holding portion 31-1 and a second holding portion 31-2) having different lengths are provided on the base portion 132, so that the holding portion 31 is an obstacle (fluorescent light). imaging device 200) can be bypassed. That is, the relatively short first holding portion 31 - 1 holds the emission end 22 of the light guide member 20 at the irradiation position on the side closer to the base portion 132 . A relatively long second holding portion 31-2 holds the emission end 22 of the light guide member 20 to the irradiation position farther from the base portion 132 in a manner that bypasses the visual field range of the fluorescence imaging device 200. do. As a result, the emission end 22 of the light guide member 20 can be arranged at an appropriate irradiation position while suppressing the holding portion 31 and the light guide member 20 from being reflected in the fluorescence image.

Although FIG. 10 shows an example in which the holding portion 31 is attached to the flat plate portion 133b on the upper side of the base portion 132, as shown in FIG. may be

(Other modifications)
In the above-described embodiment, the holding portion 31 includes a plurality of joint mechanisms 40 connected in series between the one end portion 31a and the other end portion 31b, but the present invention is not limited to this. In the present invention, the holding portion 31 does not have to include the joint mechanism 40 . The entire holding portion 31 may be configured by a member capable of bending deformation. This also allows the one end portion 31a of the holding portion 31 to be adjusted to an arbitrary position and angle. However, if the entire holding portion 31 is bent and deformable, the degree of freedom in the shape of the holding portion 31 becomes too large, and there is a possibility that the work of determining the position and angle of the one end portion 31a will be complicated. Therefore, it is preferable to provide the holding portion 31 with a necessary and sufficient number of joint mechanisms 40 .

In the above embodiment, an example was shown in which the joint mechanism 40 includes the rod-like link 41 and the joint 42 that rotatably holds the link 41, but the present invention is not limited to this. In the present invention, the joint mechanism 40 may be constructed by connecting a plurality of joints in series without providing links.

In the above embodiment, an example in which the joint 42 is a spherical joint is shown, but the present invention is not limited to this. In the present invention, joint 42 may be a universal joint. Alternatively, the joint 42 may be a one-degree-of-freedom revolving joint that allows the link to rotate only in a specific direction. In this case, it is preferable to combine the joints so that the rotational directions of the joints are different from each other.

In the above embodiment, an example in which the holding portion 31 is provided with the guide portion 55 for guiding the light guide member 20 is shown, but the present invention is not limited to this. In the present invention, the guide portion 55 may not be provided.

Although the guide part 55 is a groove formed on the outer surface of the one end part 31a in the above embodiment, the present invention is not limited to this. FIG. 12 shows a second modification in which the guide portion 55 is a protrusion formed on the outer surface of the one end portion 31a. In FIG. 12, the outer surface of the one end portion 31a is formed with a guide portion 55 consisting of a rib-like projection extending along the central axis of the one end portion 31a. Both side surfaces of the projection are guide surfaces 55a. By arranging the light guide member 20 along one of the guide surfaces 55a, the output end 22 can be precisely arranged in the direction of the central axis of the one end portion 31a.

In the above embodiment, the ring-shaped fixing member 56 holds (fixes) the light guide member 20 to the one end portion 31a of the holding portion 31, but the present invention is not limited to this. In the present invention, the light guide member 20 may be fixed to the one end portion 31a by fixing means other than the fixing member 56. FIG. The fixing means is, for example, an adhesive tape, a pinch member, a binding band, or the like. An engaging structure for engaging the light guide member 20 with the one end portion 31a of the holding portion 31 may be provided.

In the above embodiment, an example was shown in which the holding part 31 has the deformable member 50 that can be bent and deformed by an external force and that can maintain its shape, but the present invention is not limited to this. In the present invention, the deformable member 50 may not be provided on the holding portion 31 . As shown in FIG. 11, the tip of the link 41 may constitute the one end 31a.

Also, in the above embodiment, an example in which the deformable member 50 constitutes the one end portion 31a was shown, but the present invention is not limited to this. In the present invention, deformable member 50 may be positioned between one end 31a and the other end 31b. For example, deformable member 50 may be provided in place of joint 42 .

Although an example in which a plurality of holding portions 31 are provided has been shown in the above embodiment, the present invention is not limited to this. In the present invention, only one holding portion 31 may be provided.

Further, in the above embodiment, the holding portion 31 includes the first holding portion 31-1 having the first length L1 and the second holding portion 31-2 having the second length L2 longer than the first length L1. Although an example including and is shown, the present invention is not limited to this. In the present invention, multiple holding portions 31 may have the same length.

In the above embodiment, the number of joint mechanisms 40 included in the holding portion 31 and the length of the link 41 connected to the joint 42 can be changed by configuring the joint 42 to be disassembled and assembled. However, the present invention is not limited to this. The number of articulation mechanisms 40 may be irreversible. The link 41 connecting to the joint 42 may not be changeable (replaceable). In other words, the holding part 31 may have a predetermined number of joint mechanisms 40 and the components may not be replaceable.

In the above embodiment, an example in which the base portion 32 is provided with the mounting portion 32b to which the holding portion 31 can be attached and detached has been shown, but the present invention is not limited to this. In the present invention, the base portion 32 may not be provided with the mounting portion 32b. That is, the holding portion 31 may be provided on the base portion 32 in a non-removable manner. For example, the other end portion 31b of the holding portion 31 may be joined to the base portion 32 by an irreversible technique such as welding, fusion welding, or adhesion. The holding portion 31 and the base portion 32 may be integrally formed.

In the above-described embodiment, an example is shown in which the base portion 32 is provided with the operation portion 65 for switching between the fixed state of pressing the contact surface 32c against the structure 110 and the released state of releasing the pressing. is not limited to In the present invention, the operation portion 65 may not be provided on the base portion 32 . The base portion 32 may be attached to the structure 110 by, for example, screwing or adhesion (adhesion). Alternatively, the base portion 32 may be attached to the structure 110 using, for example, magnetic force or pressure (air pressure).

[Aspect]
It will be appreciated by those skilled in the art that the exemplary embodiments described above are specific examples of the following aspects.

(Item 1)
A light irradiation device for irradiating a treatment target site of a subject to which a drug containing a photosensitizer is administered with therapeutic light,
a light source that generates therapeutic light;
a cable-shaped light guide member including an incident end connected to the light source unit and an emitting end for emitting light incident on the incident end;
an arm-shaped holding part having one end for holding the output end of the light guide member and the other end opposite to the one end, the holding part being provided so that the position and angle of the one end can be adjusted;
A light irradiation device, comprising: a base portion that is provided so as to be attachable to a structure and that supports the other end portion of the holding portion.

(Item 2)
The light irradiation device according to item 1, wherein the holding section includes a plurality of joint mechanisms connected in series between the one end and the other end.

(Item 3)
3. The light irradiation device according to item 2, wherein the joint mechanism includes a rod-shaped link and a joint that rotatably holds the link.

(Item 4)
The light irradiation device according to item 3, wherein the joint is a spherical joint.

(Item 5)
One end has a rod-like shape,
The light irradiation device according to Item 1, wherein the holding portion has a guide portion that guides the light guide member along a direction in which the one end portion extends.

(Item 6)
Item 6. The light irradiation device according to Item 5, wherein the guide portion is a groove or protrusion formed on the outer surface of the one end portion, and has a guide surface on which a part of the light guide member can be arranged.

(Item 7)
The holding part has a deformable member that can be bent and deformed by an external force and can maintain its shape,
Item 2. The light irradiation device according to item 1, wherein the deformable member constitutes one end of the holding part.

(Item 8)
the light source unit includes a plurality of light output ports to which the light guide member can be connected,
Item 1. The light irradiation device according to item 1, wherein the base portion includes a plurality of mounting portions to which the holding portion can be attached and detached.

(Item 9)
The light irradiation device according to item 1, wherein the holding portion includes a first holding portion having a first length and a second holding portion having a second length greater than the first length.

(Item 10)
The base part is
a contact surface that can contact a structure;
an operation unit for switching between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure and a release state in which the pressing is released;
The light irradiation device according to item 1, comprising:

(Item 11)
A light guide member holder for holding a cable-shaped light guide member including an emission end for irradiating a treatment target site of a subject to which a drug containing a photosensitizer is administered with therapeutic light,
an arm-shaped holding part having one end for holding the output end of the light guide member and the other end opposite to the one end, the holding part being provided so that the position and angle of the one end can be adjusted;
A light guide member holder, comprising: a base portion that is provided so as to be attachable to a structure and that supports the other end portion of the holding portion.

REFERENCE SIGNS LIST 10 light source section 12 light output port 20 light guide member 21 incident end 22 emission end 30 light guide member holder 31 holder 31-1 first holder 31-2 second holder 31a one end 31b other end 32, 132 Base part 32b Mounting part 32c Contact surface 40 (40a, 40b, 40c) Joint mechanism 41 Link 42 Joint 50 Deformable member 55 Guide part 65 Operation part 80 Treatment light 100 Light irradiation device 101 Cancer patient (subject)
101a treatment target site 102 drug 110 structure

Claims (11)

1. A light irradiation device for irradiating a treatment target site of a subject to which a drug containing a photosensitizer is administered with therapeutic light,
   a light source that generates therapeutic light;
   a cable-shaped light guide member including an incident end connected to the light source unit and an emitting end for emitting light incident on the incident end;
   an arm-shaped holding part having one end for holding the emitting end of the light guide member and the other end opposite to the one end, the holding part being provided so that the position and angle of the one end can be adjusted; ,
   and a base portion that is attachable to a structure and that supports the other end portion of the holding portion.
2. The light irradiation device according to claim 1, wherein the holding section includes a plurality of joint mechanisms connected in series between the one end and the other end.
3. The light irradiation device according to claim 2, wherein the joint mechanism includes a rod-shaped link and a joint that rotatably holds the link.
4. The light irradiation device according to claim 3, wherein the joint is a spherical joint.
5. The one end has a rod-like shape,
   The light irradiation device according to claim 1, wherein the holding portion has a guide portion that guides the light guide member along the direction in which the one end portion extends.
6. The light irradiation device according to claim 5, wherein the guide portion is a groove or protrusion formed on the outer surface of the one end portion, and has a guide surface on which a part of the light guide member can be arranged.
7. The holding part has a deformable member that can be bent and deformed by an external force and can maintain its shape,
   2. The light irradiation device according to claim 1, wherein said deformable member constitutes said one end of said holding portion.
8. the light source unit includes a plurality of light output ports to which the light guide member can be connected,
   2. The light irradiation device according to claim 1, wherein said base portion includes a plurality of attachment portions to which said holding portions are attachable and detachable.
9. The light irradiation device according to claim 1, wherein the holding portion includes a first holding portion having a first length and a second holding portion having a second length longer than the first length.
10. The base portion
    a contact surface capable of contacting the structure;
    an operation unit that switches between a fixed state in which the contact surface is fixed to the structure by pressing the contact surface against the structure, and a release state in which the pressure is released;
    The light irradiation device according to claim 1, comprising:
11. A light guide member holder for holding a cable-shaped light guide member including an emission end for irradiating a treatment target site of a subject to which a drug containing a photosensitizer is administered with therapeutic light,
    an arm-shaped holding part having one end for holding the emitting end of the light guide member and the other end opposite to the one end, the holding part being provided so that the position and angle of the one end can be adjusted; ,
    A light guide member holder, comprising: a base portion that is provided so as to be attachable to a structure, and that supports the other end portion of the holding portion.

Images