WO2022250227A1 - Nasal spray liquid composition - Google Patents

Abstract

The present invention relates to a liquid composition and, more specifically, to a nasal spray liquid composition.

Description

Liquid composition for nasal spray

The present invention relates to a spray composition, and more particularly to a liquid composition for nasal spray.

In general, the nose serves as an entrance to the airway and contains the olfactory organ. It supplies and filters the air necessary for breathing by smelling, and warms and humidifies the supplied air. It also removes foreign substances that come in when you breathe in the air. The nose has two cavities separated by a cartilaginous wall, and the outward opening is called the nasal cavity. The palate bone forms the roof of the mouth and the lower surface of the nasal cavity. The palate bone in the mouth is commonly called the hard palate. The soft palate (軟口蓋) extends to the nasopharynx, so when you swallow food, pressing it from the top closes the nasopharynx so that food does not pass to the back of the nose. The nasal cavity has a complex structure. The front part of the nasal cavity is called the nosal vestibule. Behind the nasal vestibule, along each lateral wall, there are usually three ridges extending progressively from anterior to posterior. Each turbinate, called the superior, middle, and inferior turbinates, protrudes from the air passage. The part related to the sense of smell in the nasal cavity is the upper part of the gastric turbinate and its surroundings. The rest is for breathing, and is made up of moist mucous membranes with cilia, which are delicate hair-like projections (which serve to filter foreign matter). Mucus secreted by cells in the membrane walls filters dust, carbon, soot, and bacterial particles. The paranasal sinuses are located within the skull on either side of the nose. Most of the olfactory area is covered with mucous membranes, and only a part is made up of nerve cells, which are actual sensory organs. Fibers called dendrites that extend from nerve cells into the nasal cavity are covered only with a thin layer of moisture. This moisture dissolves microscopic particles transported to the nose from odorous substances through the air, and the particles chemically stimulate the olfactory nerve cells.

On the other hand, the above nasal cavity normally secretes antibacterial substances such as lysozyme and lactoferrin to act as a defense shield for the human body to prevent the access of viruses or infectious agents harmful to the human body. makes it difficult for the nasal cavity to fully exert its antibacterial function.

In addition, recently, deadly pathogens such as corona virus that exceed the level harmful to the human body have appeared, and infections caused by them have become prevalent. These harmful and deadly pathogens in the air can be mixed with saliva, runny nose, and phlegm sprayed into the air from the pathogen and can be infected through the mucous membrane of the human respiratory tract. very important.

Therefore, it is urgent to develop a liquid composition for nasal spray that is harmless to the human body and can prevent respiratory infections by rapidly killing pathogens introduced into the nasal cavity.

The present invention has been devised in view of the above, to provide a liquid composition for nasal spray that is harmless to the human body and can quickly kill pathogens such as viruses and bacteria that stay in the nasal mucosa or enter through the nasal cavity. There is a purpose.

The present invention has been devised in view of the above points, and the present invention provides a liquid composition for nasal spray containing nitrogen monoxide as an active ingredient.

According to one embodiment of the present invention, the nitrogen monoxide water is introduced by introducing external air into the air inlet unit 10, applying electric field energy to the introduced air from the plasma discharge unit 20 to obtain nitrogen monoxide, Generating a first mixture containing active oxygen and active molecules, transferring the generated first mixture to a magnetic field processing unit 30 and applying a magnetic field to maintain an excited state, filtering the first mixture to which the magnetic field was applied Filtering substances other than nitrogen monoxide gas by supplying it to the unit 40, supplying the nitrogen monoxide gas that has passed through the filter unit 40 to the steam mixing unit 50 to obtain a second mixture in which water vapor and nitrogen monoxide gas are mixed Preparing the second mixture in the form of microbubbles through a micro bubbler 60 and transferring the second mixture in the form of microbubbles to a water bath 70 to dissolve in purified water It can be.

In addition, in order to maximize the contact area between the water vapor and the nitrogen monoxide gas and to lengthen the contact time for the nitrogen monoxide to be absorbed into the water vapor, the nitrogen monoxide gas and the water vapor may be mixed while rotating in the same direction. To this end, the steam mixing unit 50 is composed of a cylindrical inner cylinder 51 and a cylindrical outer cylinder 52 outside the inner cylinder 51, and gas passes between the inner cylinder 51 and the outer cylinder 52. A gas flow path 53 is formed, and the nitrogen monoxide gas passing through the filter unit 40 is supplied to the gas flow path 53 through the nitrogen monoxide supply unit 53 coupled to the outer cylinder 52. However, nitrogen monoxide gas is supplied to the gas flow path 53 in the same direction as the tangential direction of the outer cylinder 52 so that the gas flow path 53 is rotated, and the steam is supplied to the steam supply unit 55 is generated and supplied to the gas flow path 53, and water vapor is supplied to the gas flow path 53 in the same direction as the tangential direction of the outer cylinder 52, and monoxide supplied by the nitrogen monoxide supply unit 54 Nitrogen gas may be supplied to rotate the gas flow path 53 in the same direction as the rotation direction of the nitrogen gas.

In addition, the plasma discharge unit 20 has a tunnel-type air flow pipe 21 in a rectangular shape with a hollow inside and a longitudinal cross-section formed left and right in which air introduced into the air inlet 10 flows, and the tunnel-type air flow pipe 21 An electrode fixing plate 22 installed long in the longitudinal direction of the tunnel type air flow pipe 21 on both left and right outside of the air flow pipe 21, one side of which is fixed to the electrode fixing plate 22, and the other side of the tunnel type air flow pipe 21. A set of left and right pairs installed so that the other ends are horizontally close to each other from the left and right sides of the flow pipe 21 to the inner center of the tunnel-type air flow pipe 21 are spaced apart from each other at a certain distance at the top and bottom to form a pair of up and down A plurality of electrodes 23 spaced apart from each other in the longitudinal direction of the electrode fixing plate 22 and installed in a plurality of electrodes 23, and a power supply unit 24 for applying power to the electrodes 23,

The introduced air may pass through the tunnel-type air flow pipe 21 to which power is applied so as to have a pattern in which the frequency band increases from the electrode at the inlet side of the tunnel-type air flow pipe 21 to the electrode at the outlet of the tunnel-type air flow pipe. have.

In addition, power may be applied in a pattern in which a frequency band increases from an electrode rod at an inlet side of the tunnel-type air flow pipe to an electrode rod at an outlet side of the tunnel-type air flow pipe.

Also, the frequency band may have an increasing pattern from 100 Hz to 800 Hz.

In addition, the electrode may be sintered by including 1 to 5% by weight of platinum, 5 to 15% by weight of cobalt, and ceramics including zeolite in the remaining amount.

In addition, the steam supplied from the steam mixing unit 50 may have a temperature of 3 to 10 °C.

In addition, nitrogen monoxide may be contained in the liquid composition for nasal spray so that nitrogen monoxide is contained in a concentration of 0.01 to 50 ppm.

In addition, sodium chloride may be further contained at a concentration of 0.9 to 1.5% by weight in the liquid composition for nasal spray.

The liquid composition for nasal spray according to the present invention is harmless to the human body and can quickly kill pathogens such as viruses and bacteria that stay in the nasal mucosa or enter through the nasal cavity without causing discomfort during use, thereby causing respiratory infections and lesions can be prevented. In addition, even when stored for a long time, loss of active ingredients through vaporization can be minimized, so that efficacy can be maintained for a long period of time.

1 is a view showing a schematic structure of a manufacturing apparatus for producing nitrogen monoxide water contained in an embodiment of the present invention.

2 is a view showing a plasma discharge unit of a manufacturing apparatus for producing nitrogen monoxide contained in an embodiment of the present invention.

Figure 3 is a view showing the internal structure of the water vapor mixing unit of the manufacturing apparatus for producing nitrogen monoxide contained in an embodiment of the present invention.

4 is a test report by an authorized institution for the concentration of nitrogen monoxide in the nitrogen monoxide water contained in Example 1 of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. This invention may be embodied in many different forms and is not limited to the embodiments set forth herein.

The liquid composition for nasal spray according to the present invention contains nitrogen monoxide as an active ingredient.

The nitric oxide water serves to kill pathogens present in the nasal mucosa or introduced through the nasal cavity and settled in the nasal mucosa. The nitrogen monoxide solution may be used without limitation if it is prepared through a known method. Known methods include a method of reducing concentrated nitric acid with bismuth, copper, lead, mercury, etc., a method of reacting a mixed gas of nitrogen and oxygen at high temperature, a method of obtaining ammonia by heating it in the presence of a platinum catalyst and oxygen, and nitrogen monoxide There are methods of dissolving gas through methods such as forcibly bubbling water into water. These methods have various problems, such as not being easy to manufacture nitrous oxide water or containing components that are difficult to apply to the human body during the manufacturing process. Have. In addition, the obtained nitrogen monoxide water may contain components that may be harmful to the human body, such as nasal mucosa, such as nitrogen dioxide, nitrogen trioxide, and ozone, in addition to nitrogen monoxide, so it may be unsuitable for use as a nasal spray. In addition, as will be described later, in the case of a liquid composition for nasal spray, it may be desirable to contain nitrogen monoxide at a high concentration, but it may be difficult to prepare high concentration nitrogen monoxide water using these known methods. In addition, in the case of nitrogen monoxide prepared by a known method, even when applied to the nasal mucosa, nitrogen monoxide is evaporated and lost while being applied to the surface of the mucous membrane or immediately after application, so that sufficient pathogen killing effect is not expressed. there is Furthermore, even if nitrogen monoxide is prepared so that nitrogen monoxide is contained at a predetermined concentration or higher immediately after production, nitrogen monoxide is rapidly reduced after a certain period of time, so that it is difficult to fully demonstrate the killing performance of the desired pathogen or the killing performance may not exist. can

Therefore, preferably, the nitrogen monoxide water may be produced by a manufacturing method using a predetermined nitrogen monoxide water production device to be described later, and through this, it is possible to obtain nitrogen monoxide water in which nitrogen monoxide is dissolved at a high concentration, while Since it does not contain other harmful components, there is an advantage in that the prepared nitrogen monoxide water can be directly added to the preparation of a liquid composition for nasal spray without additional treatment. Specifically, the nitrogen monoxide water production apparatus reacts a mixed gas of nitrogen and oxygen, for example, air, using a plasma to obtain nitrogen monoxide, and while increasing the yield of generated nitrogen monoxide, the obtained nitrogen monoxide is added to purified water at a high concentration. It is a device designed to store

Looking at the manufacturing method using such a manufacturing device, the nitrogen monoxide water is monoxide by injecting external air into the air inlet 10, applying electric field energy to the introduced air in the plasma discharge unit 20 Generating a first mixture containing nitrogen, active oxygen and active molecules, transferring the generated first mixture to a magnetic field treatment unit 30 and applying a magnetic field to maintain an excited state, first mixture to which the magnetic field is applied Filtering substances other than nitrogen monoxide gas by supplying to the filter unit 40, supplying the nitrogen monoxide gas that has passed through the filter unit 40 to the steam mixing unit 50 to obtain a mixture of water vapor and nitrogen monoxide gas. 2 Step of generating a mixture, preparing the second mixture in the form of micro bubbles through a micro bubbler 60, and transferring the second mixture in the form of micro bubbles to the water tank 70 to dissolve in purified water can be manufactured, including

Referring to Figure 1, the nitrogen monoxide water production device capable of producing nitrogen monoxide water, which is an active ingredient of the present invention, largely includes an air inlet 10; Plasma discharge unit 20; a magnetic field processing unit 30; filter unit 40; Steam mixing unit 50; a micro bubbler (60); A water tank 70;

External air is introduced into the air inlet 10 and the introduced air flows into the plasma discharge unit 20 . In addition, a purification filter may be provided in the air inlet 10 to allow purified air to flow in.

In addition, the plasma discharge unit 20 serves to generate nitrogen monoxide gas, active oxygen, and active molecules by applying electric field electron energy to the introduced external air.

At this time, the plasma discharge unit 20 may have a structure in which electrodes 23 are provided in a tunnel-type air flow pipe 21 through which air flows, and more specifically, several sets of electrodes 23 are disposed in the air flow pipe. More specifically, four sets of electrodes 23 are set up and down and left and right in the air flow pipe 21 so that each set is spaced apart from each other and installed in a row to generate nitrogen monoxide gas. efficiency can be increased.

To this end, the plasma discharge unit 20 may include a tunnel-type air flow pipe 21, an electrode fixing plate 22, an electrode 23, and a power supply unit 24.

The tunnel-type air flow pipe 21 has a rectangular structure in which the air introduced into the air inlet 10 flows and the longitudinal section is formed to be long from side to side and the inside is hollow. In addition, the tunnel-type air flow tube 21 is preferably made of a quartz tube in order to prevent outflow of high-temperature plasma generated by discharge from the electrode 23 and electrical charge to the outside.

In addition, the electrode rod fixing plate 22 is installed long in the longitudinal direction of the tunnel-type air flow pipe 21 at both left and right outside of the tunnel-type air flow pipe 21 .

In addition, a plurality of electrode rods 23 are installed at regular intervals in the longitudinal direction of the electrode rod fixing plate 22, one side is fixed to the electrode rod fixing plate 22, and the other side is the tunnel type air flow pipe 21 It is installed horizontally from both left and right sides of the tunnel-type air flow pipe 21 to the inner center of the tunnel-type air flow pipe 21 so that the other end is close to it, and is installed vertically at a certain distance from the top and bottom, respectively, and two pairs of top, bottom, left and right are made as a set .

The electrode 23 may be used without limitation in the case of an electrode used for general plasma discharge. However, depending on the material of the electrode, there may be a significant difference in the concentration of the obtained nitrogen monoxide solution or the amount of other unwanted ozone-like gases. It is preferable to use a sintered electrode made of ceramic components in weight percent and the remaining amount. If a sintered electrode containing commonly used platinum, tungsten, silver, or cobalt is used, the generation of AM may be significantly increased and the generation of nitrogen monoxide may be insignificant. Here, the ceramic may contain at least one selected from the group consisting of zeolite, mullite, chabazite, bentonite, and mordenite, and preferably may include zeolite. If it is composed only of other types of ceramics without including zeolite, there is a concern that the amount of nitrogen monoxide generated is small and/or by-products such as ozone other than nitrogen monoxide are generated. Meanwhile, the ceramic may contain at least 60% by weight of zeolite.

In addition, the power supply unit 24 applies power to the electrode bar 23 . At this time, when charging and discharging by supplying high voltage and high frequency power to the electrode 23 through the power supply unit 24, an instantaneous high-temperature plasma is generated, and N ₂ present in the external air through the generated plasma The covalent bond of O ₂ is decomposed, and nitrogen monoxide gas is generated. The high voltage applied here may be, for example, 10 to 100 kV.

Meanwhile, the amount of nitrogen monoxide gas generated may vary depending on the frequency band of the applied power. Accordingly, it is possible to adopt a method of operating by varying the frequency according to the amount of nitrogen monoxide gas generated, but there is no measuring device capable of measuring the amount of nitrogen monoxide gas generated in real time, and even if this is adopted, the structure of the device becomes very complicated. There are concerns. In addition, various problems such as undesirable ozone generation by high frequency and voltage or low concentration of obtained nitrogen monoxide water may occur. Accordingly, it is preferable that the nitrogen monoxide production device adopts a multi-stage frequency fixing method in which power of a high frequency is gradually supplied in the direction of air flow.

To this end, the power supply unit 24 supplies power so that high frequency power is gradually supplied from the electrode 23 located in the inlet direction of the tunnel type air flow pipe 21 to the electrode 23 located in the outlet direction. It is desirable to apply For example, the frequency of the applied power may be such that power of a higher frequency is gradually supplied from 100 Hz to 800 Hz from the electrodes located in the inflow direction of the tunnel type air flow pipe 21 to the electrodes located in the outlet direction.

In this way, when the power supply unit 24 gradually supplies high-frequency power from the electrode 23 located in the inlet direction of the tunnel-type air flow pipe 21 to the electrode 23 located in the outlet direction, the purpose It is possible to efficiently generate nitrogen monoxide gas while reducing the generation of gas that does not occur, and it is possible to improve the yield of nitrogen monoxide gas.

On the other hand, in order to further improve the yield of nitrogen monoxide gas generated through the plasma discharge unit 20, the introduced air may be cooled to 5° C. or less, and has a high density (1.2 mmHg or more) cooled to 5° C. or less. When air is passed through the plasma discharge unit 20 to generate plasma discharge, the covalent bond of N ₂ and O ₂ in the air is decomposed and the NO generation efficiency can be further improved. To this end, a first cooling unit 90 may be provided between the air inlet 10 and the plasma discharge unit 20 to cool the introduced air.

The first mixture containing nitrogen monoxide gas obtained through the plasma discharge unit 20 is supplied to the magnetic field processing unit 30 . The magnetic field treatment unit 30 maintains an excited state by applying a magnetic field to the first mixture containing nitrogen monoxide gas, active oxygen, and active molecules transported from the plasma discharge unit 20, so that the nitrogen monoxide gas obtained is converted into nitrogen dioxide. It plays a role in preventing conversion to undesirable substances such as That is, the obtained nitrogen monoxide gas can be easily converted into NO ₂ as it has an unstable state such as NO ^- and NO ⁺ . The magnetic field applied from the magnetic field processing unit 30 maintains the excited state of the nitrogen monoxide gas so as to obtain monoxide. It prevents nitrogen gas from being converted to other substances that are not desired.

In addition, the first mixture including nitrogen monoxide gas, active oxygen, and active molecules that have passed through the magnetic field processing unit 30 is supplied to the filter unit 40, and substances other than nitrogen monoxide gas are filtered through the filter unit 40. It becomes. The filter unit 40 includes an ozone (O ₃ ) removal filter unit, a first adsorption filter, and a nitrogen oxide (NOX) removal filter unit, and the ozone removal filter unit contains copper oxide (CuO), manganese dioxide (MnO ₂ ), and silver oxide. (Ag ₂ O), cobalt oxide (Co ₂ O ₃ ), and at least one catalyst material selected from the group consisting of carbon is used impregnated with a porous carrier or filter paper, for example, a catalyst commercialized as Hopcalyte may be used. In addition, the first adsorption filter may contain one or more oxidation catalysts selected from the group consisting of Co, Ni, Cu, Fe, Mn, Cr, Ti, Zn, Pb, Mo, V and W, and the A nitrogen oxide (NOX) removal filter unit impregnated with at least one of zeolite, cerium oxide (CeO) and lithium chloride (LiCl) may be used as a porous carrier or filter paper.

Next, the nitrogen monoxide gas passing through the filter unit 40 is moved to the steam mixing unit 50, and the water vapor and nitrogen monoxide gas are mixed.

As described above, since the nitrogen monoxide gas generated by the plasma discharge unit 20 is in a very unstable state, it can combine with oxygen present in the air in a very short time (within a few seconds) and recombine into NO ₂ . There is a problem in that the amount of nitrogen monoxide gas produced is reduced, and there is a problem in that the concentration of nitrogen monoxide in the finally obtained nitrogen monoxide water is significantly reduced.

However, the nitrogen monoxide gas that has passed through the filter unit 40 in a short time can prevent nitrogen monoxide gas from being recombined with oxygen while going through a process in which water vapor and nitrogen monoxide gas are mixed in the steam mixing unit 50. . In addition, nitrogen monoxide gas is absorbed in water vapor at a high concentration, and through this, nitrogen monoxide gas can more easily dissolve the absorbed water vapor in preparation for dissolving nitrogen monoxide gas alone in purified water contained in the water tank 70 described later. It has the advantage of being able to produce high-concentration nitrogen monoxide water.

At this time, the steam supplied from the steam mixing unit 50 may have a temperature of 3 to 10 ° C, and high concentration of nitrogen monoxide water can be produced by mixing the steam with a temperature of 3 to 10 ° C and nitrogen monoxide gas. If steam outside this temperature range is used, it may be difficult to obtain a high concentration of nitrogen monoxide water at a desired level. The water vapor may be obtained using, for example, a piezoelectric element, and the water vapor obtained using a piezoelectric element has the advantage of increasing the absorption of nitrogen monoxide gas as the water particles are very fine like fog.

In addition, the water vapor preferably does not contain oxygen, and more preferably may be obtained by vaporizing purified water that does not contain oxygen using a piezoelectric element.

According to an embodiment of the present invention, the water vapor and nitrogen monoxide gas mixed in the steam mixing unit 50 maximize the contact area between the water vapor and the nitrogen monoxide gas and lengthen the contact time for nitrogen monoxide to be absorbed into the water vapor to obtain a high concentration. In order to generate nitrogen monoxide water, water vapor and nitrogen monoxide gas may be mixed while rotating.

To this end, the steam mixing unit 50 is provided with a cylindrical inner cylinder 51 and an outer cylinder 52, and a gas flow passage 53 is formed between the inner cylinder 51 and the outer cylinder 52, It consists of a nitrogen monoxide supply unit 54 for supplying nitrogen monoxide to rotate the gas flow path 53 and a steam supply unit 55 for supplying steam to rotate the gas flow path 53.

The steam mixing unit 50 is composed of a cylindrical inner cylinder 51 and a cylindrical outer cylinder 52 outside the inner cylinder 51, and gas flows between the inner cylinder 51 and the outer cylinder 52. A gas flow passage 53 is formed.

In addition, the nitrogen monoxide supply unit 54 is coupled to the outer cylinder 52 to supply the nitrogen monoxide passed through the filter unit 40 to the gas flow passage 53, but the outer cylinder 52 It serves to supply nitrogen monoxide to the gas flow path 53 in the same direction as the tangential direction so that the gas flow path 53 can be supplied in a rotational manner.

In addition, the steam supply unit 55 uses a piezoelectric element as described above, and specifically, by applying electricity to the piezoelectric element to vibrate the diaphragm, the vibration generated by crushing the water into water vapor is generated. The principle of a general ultrasonic humidifier It may be designed using the same principle as The piezoelectric element uses a product in which a hole for supplying water is formed in the center of the piezoelectric element and is attached to the gas flow path 53 through which nitrogen monoxide gas passes to supply only pure water vapor without mixing with air.

In addition, the steam supply unit 55 generates steam and supplies it to the gas flow path 53, but supplies the steam to the gas flow path 53 in the same direction as the tangential direction of the outer cylinder 52. and serves to supply water vapor to rotate the gas flow path 53 in the same direction as the rotation direction of the nitrogen monoxide supplied by the nitrogen monoxide supply unit 54.

As described above, the present invention rotates water vapor in a nitrogen monoxide (NO) environment to maximize the contact area between nitrogen monoxide (NO) and water vapor, thereby lengthening the contact time for nitrogen monoxide to be absorbed into water vapor to generate high-concentration nitrogen monoxide water You can do it.

On the other hand, according to an embodiment of the present invention, the nitrogen monoxide gas that has passed through the filter unit 40 may be cooled to a level of 3 to 7 ° C and supplied to the steam mixing unit 50, for example, and the cooled nitrogen monoxide When the gas is supplied to the steam mixing unit 50, the density of the nitrogen monoxide gas increases, so that a larger amount of nitrogen monoxide gas can be mixed with the steam, so that high-concentration nitrogen monoxide water can be produced. To this end, nitrogen monoxide passed through the filter unit 40 is located between the filter unit 40 and the steam mixing unit 50 to increase the density of the nitrogen monoxide gas passed through the filter unit 40. It is preferable to have a second cooling unit 100 that cools the gas.

In addition, the second mixture of steam and nitrogen monoxide gas mixed by the steam mixing unit 50 may be bubbled by the micro bubbler 60. The micro bubbler 60 serves to generate a mixture of water vapor and nitrogen monoxide gas mixed by the steam mixing unit 50 in the form of bubbles. When the mixture of water vapor and nitrogen monoxide gas is finely bubbled by the micro bubbler 60, the fine bubbles of the mixture can be easily dissolved in the purified water contained in the water tank 70 to be described later, so that a higher concentration of nitrogen monoxide creation is possible. The micro bubbler 60 may use a commercially available micro bubbler or micro bubble device, and the present invention is not particularly limited thereto.

In addition, the water tank 70 serves to supply bubbles of a mixture of water vapor and nitrogen monoxide gas to the bottom by the micro bubbler 60 and to dissolve the bubbles in purified water.

In addition, the nitrogen monoxide production device is connected to the bubble supply pipe 61 supplied from the micro bubbler 60 to the water tank 70 so that purified water is supplied, so that the water tank 70 from the micro bubbler 60 It is preferable that a purified water supply unit 80 is further provided to assist in dissolving the bubbles of the gas mixture of water vapor and nitrogen monoxide supplied to the purified water. At this time, the water supplied by the purified water supply unit 80 passes through a water purification filter to supply purified water.

In this way, by supplying purified water to the bubble supply pipe 61 through the purified water supply unit 80 to help the bubbles of the gas mixture of water vapor and nitrogen monoxide dissolve in the purified water, the solubility of the nitrogen monoxide gas mixture can be increased. Here, the purified water is obtained by passing through both a cation exchange resin and an anion exchange resin, and the amount of dissolved oxygen may be 1 ppm or less, more preferably 0.5 ppm or less, even more preferably 0.1 ppm or less, still more preferably 0 ppm, and oxygen When is dissolved, there is a concern that the concentration of nitrogen monoxide in nitrogen monoxide water may decrease as nitrogen monoxide dissolved in water vapor is converted into nitrogen dioxide.

On the other hand, non-explained numeral 110 is a heater that heats the gas generated through the plasma discharge unit 20 to assist the magnetic field processing unit 30 to maintain an excited state.

The nitrogen monoxide water produced from the above-described manufacturing method may be provided to contain nitrogen monoxide in a concentration of 0.01 to 50 ppm in the liquid composition for nasal spray. If nitrogen monoxide is implemented at less than 0.01ppm, the killing effect on the desired pathogen may be insignificant. In addition, if it is contained at a concentration exceeding 50 ppm, it may not be easy to manufacture, such as an increase in the manufacturing cost of nitrogen monoxide water. In addition, the nitrogen monoxide water may contain ozone of 0.01 ppm or less, 0.005 ppm or less, 0.001 ppm or less, 0.0001 ppm or less, more preferably 0 ppm or less.

The liquid composition for nasal spray may further contain sodium chloride in addition to nitrogen monoxide, and the sodium chloride maintains a concentration of 0.85 to 0.95% by weight in the liquid composition for nasal spray, thereby causing discomfort to the user when the liquid composition for nasal spray is injected into the nasal cavity. It may be more advantageous to achieve the object of the present invention while minimizing.

Although the present invention will be described in more detail through the following examples, the following examples are not intended to limit the scope of the present invention, which should be interpreted to aid understanding of the present invention.

<Example 1>

Nitrogen monoxide water was produced using the nitrogen monoxide water production apparatus shown in FIGS. 1 to 4. Specifically, air was cooled to 5° C. through the first cooling unit and then introduced into the plasma discharge unit. At this time, the electrode in the plasma discharge unit used a sintered electrode containing 3% by weight of platinum, 10% by weight of cobalt, and zeolite in the remaining amount. From 100 Hz to 800 Hz, power was gradually supplied to the electrodes located in the exit direction. After the gas generated by discharging with the supply of electric power passed through the magnetic field treatment unit, the gas other than nitrogen monoxide gas was filtered through a filter unit composed of an ozone removal filter unit, a first adsorption filter, and a nitrogen oxide removal filter unit. Thereafter, the nitrogen monoxide gas was cooled to 5° C. again through the second cooling unit, and the cooled nitrogen monoxide gas was provided with a cylindrical inner cylinder and an outer cylinder, and the gas flow of the water vapor mixing unit was formed with a gas flow passage between the inner cylinder and the outer cylinder. The furnace was introduced through the nitrogen monoxide supply unit, and at the same time, steam at 5 ° C was introduced into the gas flow furnace. At this time, the steam was generated and introduced through a steam supply unit disposed in the gas flow furnace so that air was not mixed, and the steam was generated using purified water having a dissolved oxygen of 0 ppm through a piezoelectric element. It was supplied to the gas flow furnace in the same direction, but water vapor was supplied to rotate the gas flow furnace in the same direction as the rotation direction of the nitrogen monoxide supplied by the nitrogen monoxide supply unit.

Thereafter, in the process of transferring the mixture of water vapor and nitrogen monoxide gas to the water tank, the mixture was micro-bubbled by passing through a micro bubbler, and the micro-bubbled mixture was supplied to the water tank through the bubble supply pipe 61. At this time, , Purified water is purified water having 0ppm dissolved oxygen that has passed through both the cation exchange resin and the anion exchange resin. Purified water is injected into the bubble supply pipe through the purified water supply unit so that micro bubbles are dissolved in the purified water and collected in the water tank to obtain nitrogen monoxide water. has manufactured The nitrogen monoxide concentration of the prepared nitric oxide water obtained by requesting the nitric oxide content test to the Korea Institute of Ceramic Engineering and Technology was 13.3 ppm.

Thereafter, a liquid composition for nasal spray was prepared by dissolving sodium chloride in the prepared nitrogen monoxide solution to a final concentration of 0.9% by weight.

<Example 2>

A liquid composition for nasal spray was prepared in the same manner as in Example 1, but the frequency of power applied to the electrodes of the plasma discharge unit was fixed at 300 Hz to collect the final nitrogen monoxide solution, and the prepared nitrogen monoxide water was tested for evaluation. As a result, the concentration of nitrogen monoxide was 1.02 ppm, and a liquid composition for nasal spray was prepared using the obtained nitrogen monoxide water.

<Example 3>

A liquid composition for nasal spray was prepared in the same manner as in Example 1, but the frequency of power applied to the electrode of the plasma discharge unit was fixed at 100 Hz, and as a result of the test request evaluation, nitrogen monoxide concentration of 0.53 ppm was prepared. , prepared as a liquid composition for final nasal spray.

<Example 4>

A liquid composition for nasal spray was prepared in the same manner as in Example 1, but the frequency of power applied to the electrode of the plasma discharge unit was fixed at 800 Hz, and as a result of the evaluation of the test request, nitrogen monoxide water having a nitrogen monoxide concentration of 1.05 ppm was prepared. , prepared as a liquid composition for final nasal spray.

<Example 5>

A liquid composition for nasal spray was prepared in the same manner as in Example 1, but the frequency of power applied to the electrodes of the plasma discharge unit was increased from 800 Hz to 100 Hz from the electrodes located in the inlet direction of the tunnel-type air flow tube to the electrodes located in the outlet direction. The power was supplied by gradually changing it to a lower level. The prepared nitrogen monoxide water had a nitrogen monoxide concentration of 2.20 ppm as a result of the test request evaluation, and it was used to prepare a final liquid composition for nasal spray.

<Example 6>

A liquid composition for nasal spray was prepared in the same manner as in Example 1, but nitrogen monoxide water was prepared by omitting the ozone removal filter, and a final liquid composition for nasal spray was prepared using this.

<Examples 7 to 9>

A liquid composition for nasal spray was prepared in the same manner as in Example 6, but the electrode material of the plasma discharge part was changed to one consisting of only platinum, 10% by weight of cobalt and the remaining amount of zeolite, or 3% by weight of platinum and the remaining amount of zeolite. It was prepared as a liquid composition for nasal spray.

<Experimental Example 1>

The concentration of nitrogen monoxide and the concentration of ozone in the nitrogen monoxide water obtained in the manufacturing process of the liquid composition for nasal spray according to Examples 6 to 9 were measured and are shown in Table 1 below.

Here, the concentration of nitrogen monoxide in nitrogen monoxide water was measured using the NO Plus Detection Kit (iNtRON Biotechnology) through the manufacturer's protocol, and ozone was measured using a dissolved ozone meter (T-CP40 from Sinsche technology). did.

	Example 6	Example 7	Example 8	Example 9
plasma discharge part electrode	Platinum 3% by weight+ Cobalt 10% by weight+ remaining zeolite Sintered Sintered Electrode	platinum	Cobalt 5% by weight+ remaining zeolite Sintered Sintered Electrode	Platinum 3% by weight+ remaining zeolite Sintered Sintered Electrode
ozone removal unit	doesn't exist	doesn't exist	doesn't exist	doesn't exist
nitrous oxide water my nitric oxide Concentration (ppm)	10.7	0.02	0.08	0.03
nitrous oxide water my ozone concentration (ppm)	0	2.8	2.0	1.8

As can be seen from Table 1,

In contrast to the other examples using the nitrogen monoxide water production apparatus according to Example 6, it can be seen that nitrogen monoxide water containing nitrogen monoxide at a high concentration is produced without ozone even though there is no ozone removal unit.

Although one embodiment of the present invention has been described above, the spirit of the present invention is not limited to the embodiments presented herein, and those skilled in the art who understand the spirit of the present invention may add elements within the scope of the same spirit. However, other embodiments can be easily proposed by means of changes, deletions, additions, etc., but these will also fall within the scope of the present invention.

Claims (9)

1. A liquid composition for nasal spray comprising nitric oxide as an active ingredient.
2. According to claim 1,

   The nitric oxide water is

   introducing external air into the air inlet 10;

   generating a first mixture including nitrogen monoxide, active oxygen, and active molecules by applying electric field energy to the introduced air from the plasma discharge unit 20;

   transferring the generated first mixture to the magnetic field processing unit 30 and applying a magnetic field to maintain an excited state;

   supplying the first mixture to which the magnetic field is applied to the filter unit 40 to filter materials other than nitrogen monoxide gas;

   generating a second mixture of water vapor and nitrogen monoxide gas by supplying the nitrogen monoxide gas that has passed through the filter unit 40 to the steam mixing unit 50;

   Preparing the second mixture in the form of micro bubbles through a micro bubbler 60; and

   Transferring the second mixture in the form of microbubbles to a water tank 70 and dissolving it in purified water; Liquid composition for nasal spray prepared by including.
3. According to claim 2,

   In order to maximize the contact area between water vapor and nitrogen monoxide gas and lengthen the contact time for nitrogen monoxide to be absorbed into water vapor, the nitrogen monoxide gas and water vapor are mixed while rotating in the same direction Liquid composition for nasal spray.
4. According to claim 2,

   The plasma discharge unit 20,

   A tunnel-type air flow pipe (21) in which the air introduced into the air inlet (10) flows and has a rectangular shape with a longitudinal cross-section formed left and right and a hollow inside;

   Electrode fixing plates 22 installed long in the longitudinal direction of the tunnel-type air flow pipe 21 on both left and right sides of the tunnel-type air flow pipe 21;

   One side is fixed to the electrode rod fixing plate 22, and the other side is installed horizontally from both left and right sides of the tunnel-type air flow pipe 21 to the inner center of the tunnel-type air flow pipe 21 so that the other ends are adjacent to each other. A set of electrodes 23 installed in plurality at a predetermined interval in the longitudinal direction of the electrode fixing plate 22, each set of which is installed so that the pairs are spaced apart at a predetermined distance from the upper and lower portions to form a pair up and down;

   It includes a power supply unit 24 for applying power to the electrode 23,

   The introduced air passes through the tunnel-type air flow pipe 21 to which power is applied so as to have a pattern in which the frequency band increases from the electrode at the inlet side of the tunnel-type air flow pipe 21 to the electrode at the outlet of the tunnel-type air flow pipe. Liquid composition for nasal spray, characterized in that.
5. According to claim 4,

   The frequency band is a liquid composition for nasal spray, characterized in that it has a pattern that increases from 100Hz to 800Hz.
6. According to claim 4,

   The electrode is a liquid composition for nasal spray that is sintered with 1 to 5% by weight of platinum, 5 to 15% by weight of cobalt, and ceramics including zeolite in the remaining amount.
7. According to claim 2,

   The vapor supplied from the vapor mixing unit 50 has a temperature of 3 to 10 ° C. A liquid composition for nasal spray.
8. According to claim 1,

   A liquid composition for nasal spray, characterized in that it contains nitrogen monoxide water so that nitrogen monoxide in the liquid composition for nasal spray is contained at a concentration of 0.01 to 50 ppm.
9. According to claim 1,

   A liquid composition for nasal spray further containing sodium chloride at a concentration of 0.9 to 1.5% by weight in the liquid composition for nasal spray.

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