WO2022241330A2 - Système d'analyse de papule et d'éruption - Google Patents

Système d'analyse de papule et d'éruption Download PDF

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Publication number
WO2022241330A2
WO2022241330A2 PCT/US2022/032321 US2022032321W WO2022241330A2 WO 2022241330 A2 WO2022241330 A2 WO 2022241330A2 US 2022032321 W US2022032321 W US 2022032321W WO 2022241330 A2 WO2022241330 A2 WO 2022241330A2
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WO
WIPO (PCT)
Prior art keywords
emitter
skin
energy
patient
wavelength
Prior art date
Application number
PCT/US2022/032321
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English (en)
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WO2022241330A3 (fr
Inventor
C. Bruce BANTER
Original Assignee
Banter C Bruce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/830,843 external-priority patent/US11602301B2/en
Application filed by Banter C Bruce filed Critical Banter C Bruce
Publication of WO2022241330A2 publication Critical patent/WO2022241330A2/fr
Publication of WO2022241330A3 publication Critical patent/WO2022241330A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Definitions

  • the present invention relates generally to systems and methods providing information to medical professionals for use in evaluating patient reactions to allergens during skin testing as the reactions occur.
  • Allergy skin testing is used to determine whether an individual is allergic to a particular substance. A person often seeks allergy testing if she is experiencing allergy symptoms but does not know which allergen is causing the symptoms.
  • Allergy testing involves subjecting a patient to a wide variety of different allergens to determine which allergens cause allergic reactions in the patient. Such testing requires that the allergen is applied beneath the surface of the patient's skin.
  • the puncture method a sharply pointed needle or tine pierces the patient’s skin, and a small amount of allergen is applied.
  • abrasion method a needle, tine, or other sharp object pierces the patient’s skin and moves laterally after the initial piercing forming a scratch or an abrasion.
  • a health care provider observes the pierced area and diagnoses an allergy based on swelling, redness, or other signs of reaction. A health care provider then observes the injection site for an allergic reaction.
  • the prior art reporting is primarily directed at reporting, identifying, and preventing allergic reactions.
  • U.S. Patent No. 7420663 (Wang; et al.) is for a spectroscopic sensor on a mobile phone.
  • the spectroscopic sensor is integrated into a mobile communication device, such as a mobile phone.
  • the spectroscopic sensor measures the optical spectra of a physical object for purposes of detection, identification, authentication, and real time monitoring.
  • the mobile communication device Through the mobile communication device, the spectral information is transmitted, distributed, collected, and shared by using all the functions of the known or existing wireless communication networks.
  • U.S. Patent Application No. 15/556316 discloses software for providing health information to a user expressing symptoms of an allergic reaction via a wearable device.
  • the system acquires in real-time, substantiating feedback of indicators of allergic reaction conditions and no automatic and immediate remedial measures by commencing an interactive question and answer session with the user at the inception of detection of the condition and providing health information that is helpful to the user in remedying the condition.
  • the question-and-answer session facilitates the determination of the cause and severity of the allergic reaction.
  • U.S. Patent Application No. 10/554532 discloses a diagnostic support system and mobile terminal, which judge a morbidity possibility that a user holding the mobile terminal is suffering from a disease.
  • the analytical center includes a unit which obtains symptom data representing the symptom of the user from the mobile terminal in correspondence with a position at which and a date on which the symptom data was made, a morbidity possibility calculation unit which judges the morbidity possibility that the user is suffering from the disease.
  • Wheals and flares are formed within 10 to 15 minutes after application. Wheals are raised skin bumps and flares are discolorations around the wheal. The size of the wheals and flares are indicative of the degree of the allergic reaction. The sizes may be either visually estimated or measured.
  • allergen testing system that provides more data to the medical professional faster, that uses less allergen, that is compatible with puncture testing and scratch testing systems, that reduces the number of false negatives and is less painful to patients.
  • the wheal and flare analyzing system of the present invention addresses these needs.
  • the wheal and flare analyzing system of the present invention analyzes an allergic reaction in a mast cell to an allergen being administered in a skin test.
  • the basic components of the system for analyzing an allergic reaction within a mast cell comprise; a sensor array with multiple energy emitters and emitter light guides, and an energy receiver and receiver light guides, an Analog Front End (AFE), and a microprocessor.
  • AFE Analog Front End
  • the sensor array includes a first emitter that emits energy of a first wavelength into the skin of the patient via an emitter light guide.
  • the sensor array also includes a second emitter that emits energy of a second wavelength into the skin of the patient via a second emitter light guide.
  • the sensor array preferably includes a third emitter and light guide and a fourth emitter and light guide. The third emitter emits energy of a third wavelength into the skin of the patient via the third emitter light guide, and the fourth emitter emits energy of a fourth wavelength into the skin of the patient via a fourth emitter light guide.
  • the microprocessor is in digital communication with the AFE to sequentially control the four emitters and process the energy from the energy receiver.
  • An energy return of the first reflected wavelength, the second reflected wavelength, the third reflected wavelength, and the fourth reflected wavelength are indicative of the intensity of the allergic reaction of the allergen applied to the site in the mast cells.
  • the energy receiver and its light guide are preferably positioned in the center of the array with the emitters and their lights guide around the center.
  • the energy receiver and center of the array are preferably positioned proximate to the center of the site where the allergen is introduced into the mast cells.
  • the energy receiver measures the first reflected wavelength from the first emitter, the second reflected wavelength from the second emitter, the third reflected wavelength from the third emitter, and the fourth reflected wavelength from the fourth emitter.
  • the reflected wavelengths have an energy return indicative of the intensity of the allergic reaction in the mast cells plus increased vasodilation and congestion.
  • the intensity of the allergic reaction is analyzable from the reflected wavelength and other data over time.
  • a plurality of temperature sensors abuts the sensor array.
  • the temperature sensors measure local dermal temperature.
  • the temperature sensors are also linked to the microprocessor.
  • the local dermal temperature is indicative of the intensity of the allergic reaction.
  • the information from each of the sensor cells and the temperature measurement of the patient skin are communicated to an Application Program via a wired connection or wireless link for communication to a medical professional.
  • pierce and piercing includes a penetration of the skin.
  • a scratch or abrasion is a piercing of the skin caused by a sharp object, the sharp object moving laterally along the surface of the skin subsequent to the piercing.
  • the piercing formed may be an arcuate line, a straight line, a closed arcuate shape, or a jagged arcuate line produced on the skin.
  • a puncture or a prick is a piercing of the skin made with a sharp object that generates a hole penetrating the skin.
  • the piercing includes a wound made by a needle or tine applied into the skin, including a gouge.
  • the sharp object does not move laterally relatively to the surface of the skin subsequent to the initial piercing.
  • a puncture or a prick and “a scratch or abrasion” are mutually exclusive.
  • FIGURE 1A depicts a healthy mast cell beneath the epidermis of a patient for use in allergy skin testing.
  • FIGURE 1B depicts the healthy mast cell beneath the epidermis of a patient of FIGURE 1A under attack by a plurality of antigens.
  • FIGURE 1C depicts the mast cell of FIGURE 1 A in a full-blown allergic reaction by the release of histamines and other chemicals to protect the mast cell, resulting in a noticeable wheal formed on the epidermis of the patient.
  • FIGURE 2A depicts a prior art allergy testing system comprising a multiple applicator unit disposed relative to a fluid tray.
  • the multiple applicator unit has a grip portion for holding the device.
  • One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen.
  • Each leg has a test head, and each test head has a plurality of elongated spike members.
  • the elongated spike members have a sharp end configured to receive the potential allergen from a well in the fluid tray and to puncture the skin of the patient being tested skin.
  • FIGURE 2B depicts the multiple applicator unit of FIGURE 2A being applied onto a patient’s skin for allergy skin testing.
  • FIGURE 2C depicts the skin of the patient after the multiple applicator unit of FIGURE 2B has been removed from the patient’s skin, with markings to denote the individual test sites and reference to the allergens applied at each individual test site.
  • FIGURE 3 depicts an assembly view of the first preferred embodiment of the wheal and flare analyzing system of the present invention, the system including a microprocessor, six temperature sensors, eight sensor arrays, eight (8) AFE/LED drivers, an rf transceiver, a communications link, and a power source, all mounted relative to a printed circuit board and encapsulated.
  • DETAIL A is an exploded end view of a sensor array of the wheal and flare analyzing system of FIGURE 3.
  • FIGURE 4 depicts the wheal and flare analyzing system FIGURE 3 with eight (8) sensor arrays on a printed circuit board, with the preferred typical dimensions of the unit and the sensor arrays which need to align and be compatible with the multiple applicator unit used in the test (see FIGURE 2A).
  • a spacer ring as part of the sensor array creates space between the sensor array and the patient’s skin to enable the wheal and flare to form. It also minimizes sensor contact with the patient’s skin to minimize influencing the temperature of the patient’s skin at the test site.
  • FIGURE 5 depicts the sensor array of DETAIL A of FIGURE 3 of the wheal and flare analyzing system of the present invention disposed on the skin of a patient.
  • FIGURES 6A and 6B depict a pair of end views of simplified schematics of the sensory array of the wheal and flare analyzing system of FIGURE 3.
  • the microprocessor commands the AFE/LED drivers to power the first wavelength emitter LED to emit energy via the light guide emitter and looks for energy return via the light guide receiver at the receiver, the emitted energy being either reflected or absorbed by the surface and underlaying material of the mast cells.
  • the microprocessor commands the AFE/LED drivers to power the second wavelength emitter LED to emit energy via the light guide emitter and looks for energy return via the light guide receiver at the receiver, the emitted energy being either reflected or absorbed by the surface and underlaying material of the mast cells.
  • FIGURE 7 depicts a plot of the reaction severity plot of one wavelength over time for eight (8) different fluids and test sites.
  • FIGURE 8 depicts a simplified sensor and test site alignment for the first preferred embodiment of the wheal and flare analyzing system of FIGURE 3, depicting the markings on the patient’s skin to denote the individual test sites and reference to the allergens applied at each individual site.
  • FIGURE 9 depicts a simplified functional block diagram of the first preferred embodiment of the wheal and flare analyzing system of FIGURE 3, including the cooperative relationships of the microprocessor, the rf transceiver, the analog front end/LED drivers, the temperature sensors, the rechargeable power source, and an optional wired connection.
  • FIGURE 10 depicts a simplified process flow diagram of a preferred embodiment of the wheal and flare analyzing system of FIGURES 3.
  • FIGURE 11 depicts the wheal and flare analyzing system of FIGURE 3 placed in a sterilizing and recharging case.
  • FIGURE 1A depicts a healthy mast cell [16] beneath the epidermis [14] of a patient for use with the wheal and flare analyzing system of the present invention [10].
  • FIGURE 1 B depicts the healthy mast cell beneath the epidermis [14] of a patient of FIGURE 1A under attack by a plurality of antigens
  • FIGURE 1C depicts a full-blown allergic reaction [19] in the mast cell [16] of FIGURE 1A by the release of histamines and other chemicals to protect the mast cell [16], resulting in a noticeable wheal [22] formed on the epidermis [14] of the patient.
  • FIGURE 2A depicts a prior art allergy testing system comprising a multiple applicator unit [25] disposed relative to a fluid tray [26].
  • the multiple applicator test unit [25] is known in the prior art (see U.S. Patent No. 8469900).
  • the multiple applicator unit [25] has a grip portion for holding the device.
  • One or more legs extend from the grip portion, and each leg is oriented to interact with a reservoir containing a potential allergen.
  • Each leg has a test head [28] or tip, and each test head [28] has a plurality of elongated spike members.
  • the elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture the skin of the patient being tested.
  • FIGURE 2B depicts the multiple applicator unit [25] of FIGURE 2A being applied to a test site onto a patient’s skin for allergy skin testing.
  • FIGURE 2C depicts the skin of the patient after the multiple applicator unit [25] of FIGURE 2B has been removed from the test site, with markings on the patient’s skin to denote the individual test sites and reference to the allergens applied at each individual site. A wheal [22] is shown at one of the test sites on the patient’s skin. After removal of the applicator [25] each of the individual test sites are marked with numbers or symbols to reference each test site to the applied specific allergen.
  • FIGURE 3 depicts an assembly view of the first preferred embodiment of the wheal and flare analyzing system [10] of the present invention.
  • the basic components of the system for analyzing an allergic reaction [10] within a mast cell comprise a sensor array [40] comprising an energy receiver [44], receiver light guide [54], emitters [42], emitter
  • a space ring [50] provides an air gap with the patient’s skin.
  • the sensor array [40] includes a first emitter [42] that emits energy of a first wavelength into the skin of the patient via a first light guide emitter [52].
  • the sensor array [40] also includes a second emitter [42] that emits energy of a second wavelength into the skin of the patient via a second light guide emitter [52].
  • the sensor array preferably includes a third emitter [42] and third light guide emitter [52], a fourth emitter [42] and fourth light guide emitter [52], the third emitter emitting energy of a third wavelength into the skin of the patient via a third light guide emitter [52], the fourth emitter emitting energy of a fourth wavelength into the skin of the patient via a fourth light guide emitter [52].
  • the sensor array [40] includes a spacer ring [50] that is on the outer periphery of the sensor array and provides an air gap with the patient’s skin.
  • the microprocessor [30] is in digital communication with the AFE [38] that controls all four emitters [42] and processes the energy from the energy receiver [44].
  • An energy return of the first reflected wavelength, the second reflected wavelength, the third reflected wavelength, and the fourth reflected wavelength are indicative of the intensity of the allergic reaction of the allergen applied to the site in the mast cells.
  • the energy receiver [44] and its light guide [54] are preferably positioned in the center of the array with the emitters [42] and their lights guides [52] around the center and energy receiver [44].
  • the energy receiver [44] is preferably positioned proximate to the center of the site where the allergen is introduced into the mast cells.
  • the energy receiver [44] via the light guide receiver [54] measures the first reflected wavelength from the first emitter [42] via the light guide emitter [52], the second reflected wavelength from the second emitter [42] via the light guide emitter [52], the third reflected wavelength from the third emitter [42] via the light guide emitter [52], and the fourth reflected wavelength from the fourth emitter [42] via the light guide emitter [52].
  • DETAIL A depicts a cross section view of the sensor array [40] of the first preferred embodiment of the wheal and flare analyzing system [10] of FIGURE 3.
  • FIGURE 4 depicts the wheal and flare analyzing system of FIGURE 3 with eight (8) sensor arrays on a printed circuit board, the sensor arrays, with preferred typical dimensions of the unit and the sensor arrays which need to align and be compatible with the multiple applicator unit used in the allergy skin test (see FIGURE 2A).
  • a spacer ring as part of the sensor array creates space between the sensor array and the patient’s skin to enable the wheal and flare to form. It also minimizes sensor contact with the patient’s skin to minimize influencing the temperature of the patient’s skin at the test site.
  • FIGURE 5 depicts the sensor array [40] of the first preferred embodiment of the wheal and flare analyzing system of the present invention [10] positioned on the skin of a patient at a test site.
  • a noticeable wheal [22] has formed on the epidermis [14] of the patient, the wheal [22] being sandwiched between a pair of flares [24].
  • the spacer ring [50] also reduces sensor contact with the skin to minimize influencing the temperature of the patient’s skin at the test site.
  • the skin of the patient is depicted in an exploded view, as the activity occurring in the dermis tissue of the patient after the allergen has been inserted after a routine allergy skin test resulting in the formation of a wheal [22] in the center of the site and a flare [24] that extends on the outer periphery around the center of the wheal [22].
  • the wheal and flare analyzing system of the present invention [10] comprises a sensor array [40], analog front end [38], and a microprocessor [30].
  • the information from each of the sensor arrays [40] and the temperature measurement of the patient skin are communication to an Application Program via a wired connection [37] or a wireless link [36], from the microprocessor [30].
  • the sensory array [40] has a plurality of emitters [42] disposed about or preferably surrounding a receiver [44] and the analog front ends/LED drivers [38] at the allergen test site.
  • An energy receiver [44] adjacent to the allergen test site measures reflected wavelengths via the light guide receiver [54] from the plurality of emitters [42] via their light guides emitters [52].
  • the microprocessor [30] is in digital communication via the analog front end/LED drivers [38] with the plurality of emitters [42] and the energy receiver [44].
  • the reflected wavelengths have an energy return indicative of the intensity of the allergic reaction in the mast cells [16].
  • the intensity of the allergic reaction [19] is analyzable from the reflected wavelength and other data over time.
  • a plurality of temperature sensors (not shown) abuts the sensor array [40].
  • the temperature sensors measure local dermal temperature.
  • the temperature sensors are also linked to the microprocessor [30].
  • the local dermal temperature is indicative of the intensity of the allergic reaction [19].
  • FIGURES 6A and 6B depict a pair of simplified top views the of the sensory array [40] of the wheal and flare analyzing system of the present invention [10].
  • the microprocessor [30] commands the LED drivers [38] to power the first wavelength LED to emit energy from the emitters [42] and look for energy return at the receiver [44], the emitted energy being either reflected or absorbed by the surface and underlaying material of the mast cells [16]. The process is repeated with the second wavelength LED.
  • FIGURE 7 depicts a plot of the Reaction Severity of one wavelength over time for eight (8) different fluids and test sites.
  • Energy is preferably emitted from each emitter [42] in sequence and the reflected energy is measured by the centrally located receiver [44].
  • the energy wavelengths have unique energy returns depending on the interaction in the tissues.
  • the amount of mast cells [16], proteins, and fluids can be detected by analyzing the energy returns over time to calculate a Relative Severity.
  • the allergic reaction for each allergen is also compared to the reactions for saline (negative reaction) and histamine (positive reaction).
  • FIGURE 8 depicts the attachment of the wheal and flare analyzing system [10] to the marked test sites on the patient’s skin from FIGURE 2B.
  • the wheal and flare analyzing system [10] is aligned with the numbers or symbols for the individual test sites.
  • a reference and alignment number [51] is marked on the top of the wheal and flare
  • the markings on the patient’s skin denote the individual test sites and reference to the allergens applied at each individual site.
  • FIGURE 9 depicts a simplified functional block diagram of the first preferred embodiment of the wheal and flare analyzing system of FIGURE 3, including the cooperative relationships of the microprocessor, the rf transceiver, the analog front end/LED drivers, the temperature sensors, the rechargeable power source, and an optional wired connection.
  • FIGURE 10 depicts a simplified process flow diagram of a preferred embodiment of the wheal and flare analyzing system of FIGURES 3.
  • FIGURE 11 depicts the wheal and flare analyzing system [10] placed in a sterilizing and recharging case [62].
  • the sterilizing and recharging case [62] comprises a case base [63] a docking cradle [66], a sensor power plug [65], UV light source [67], and a case cover [64].
  • the wheal and flare analyzing system [10] is placed into the sterilizing and recharging case [62] after each use where UV light is introduced inside the closed case by the UV light source [67] to sterilize the wheal and flare analyzing system [10] and recharge the internal power source [60].
  • Recharging power is transmitted through the communication link and output connector [37] of the wheal and flare analyzing system [10] and the sensor power plug [65] of the sterilizing and recharging case [62].
  • the sterilizing and recharging case [62] communicates with the system APP that the wheal and flare analyzing system [10] is sterilized, recharged with power, and ready for use.
  • the allergic reaction [19] can be measured immediately after the application of the allergen and placement of the sensor array [40].
  • the information is a direct measure of the allergy reaction [19] occurring under the skin.
  • the temperature measurement of the patient skin is also measured to detect an increase in temperature at the reaction sites.
  • the information from the control site is used to compare the information from the other sites as a reference.
  • the information on each site is presented to the doctor to compare against visual observations. A determination of the patient susceptibility to each allergen is determined by the doctor and a course of future action and evaluation is planned.
  • the wheal and flare analyzing system of the present invention [10] provides information about the reaction immediately after the application and the information is a measurement of the reaction under the skin.
  • the information provides an insight into the amount of reaction over time and the type of reactions that are visible above the skin.
  • the information provides a digital record of the reaction that can be compared to future measurements.
  • the wheal and flare analyzing system of the present invention [10] enables the amount of allergen applied to the patient to be reduced to produce a measurable reaction.
  • the wheal and flare analyzing system of the present invention [10] enables the delivery of the allergen to the tissue requires less penetration of the dermis. This will result in less pain and false positive indications from a wheal created by the histamine release.
  • the wheal and flare analyzing system of the present invention [10] uses similar sensing technology but is focused on providing information about allergic reactions after allergy testing is conducted. The testing can be performed in a medical office or at home and self-administered. The data from the wheal and flare analyzing system of the present invention [10] is intended to augment the analysis of medical professionals.
  • the sensor array [40] can be applied to the test sites after the allergens are applied by the previous described scratch or puncture devices.
  • the sensor array [40] can remain in place by gravity when patients are immobile for the time required for the allergic reactions typically 10 to 15 minutes. Additionally, the sensor array [40] can be held in place on the patient by a restraint method such as a belt or strap or an applied adhesive.

Abstract

Le système d'analyse de papule et d'éruption analyse la réaction de mastocytes à un allergène qui est administré dans un test cutané par scarification ou piqûre. Le système comprend un réseau de capteurs et une unité de traitement. Le réseau de capteurs comprend une pluralité d'émetteurs entourant un récepteur au niveau du site de test d'allergène. De l'énergie à diverses longueurs d'onde est émise dans le site de test d'allergène. Un récepteur d'énergie mesure les différentes longueurs d'onde réfléchies provenant de la pluralité d'émetteurs. Un microprocesseur est en communication numérique avec la pluralité d'émetteurs et le récepteur d'énergie. Les longueurs d'onde réfléchies ont un retour d'énergie indiquant l'intensité de la réaction allergique dans les mastocytes. L'intensité de la réaction allergique est analysable à partir des longueurs d'onde réfléchies et d'autres données dans le temps. Une pluralité de capteurs de température mesurent des températures dermiques locales entourant le réseau de capteurs, la température dermique locale indiquant l'intensité de la réaction allergique.
PCT/US2022/032321 2021-05-13 2022-06-06 Système d'analyse de papule et d'éruption WO2022241330A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202163188125P 2021-05-13 2021-05-13
US63/188,125 2021-05-13
US202163197539P 2021-06-07 2021-06-07
US63/197,539 2021-06-07
US17/830,843 US11602301B2 (en) 2021-05-13 2022-06-02 Wheal and flare analyzing system
US17/830,843 2022-06-02

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WO2022241330A2 true WO2022241330A2 (fr) 2022-11-17
WO2022241330A3 WO2022241330A3 (fr) 2023-01-19

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Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US6629932B2 (en) * 2001-01-10 2003-10-07 Pearl Technology Holdings, Llc Allergen and irritant measuring device
CN103505222A (zh) * 2008-03-19 2014-01-15 超级医药成像有限公司 用于实时的组织氧合测量的小型化多光谱成像器
US20100100160A1 (en) * 2008-10-16 2010-04-22 Philometron, Inc. Methods and devices for self adjusting phototherapeutic intervention
KR101657953B1 (ko) * 2014-11-24 2016-09-20 주식회사 터치뷰티 피부미용기기의 충전 및 살균 케이스
AU2014415734A1 (en) * 2014-12-30 2017-04-13 Nexus Ekspertyzy I Badania Dr Jacek Stepien Contact thermo-optical structure and its application for non-invasive imaging of histamine-induced hyperthermal subcutaneous reaction magnitude in cutaneous allergic reaction, recording device and method of allergic reaction diagnosis
US10932727B2 (en) * 2015-09-25 2021-03-02 Sanmina Corporation System and method for health monitoring including a user device and biosensor
PL425395A1 (pl) * 2018-04-30 2019-11-04 Milton Essex Spolka Akcyjna Aparat do multimodalnej analizy odczynu alergicznego w przebiegu testów skórnych oraz hybrydowa metoda multispektralnego obrazowania odczynów alergicznych w przebiegu testów skórnych i jej zastosowanie do automatycznej oceny wyniku tych testów
KR102036045B1 (ko) * 2018-11-19 2019-10-24 주식회사 에프앤디파트너스 가변파장의 피부 영상 정보를 이용한 휴대용 피부질환 진단장치

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