WO2022231036A1 - Nouveau variant et procédé de production d'acide l-glutamique l'utilisant - Google Patents

Nouveau variant et procédé de production d'acide l-glutamique l'utilisant Download PDF

Info

Publication number
WO2022231036A1
WO2022231036A1 PCT/KR2021/005454 KR2021005454W WO2022231036A1 WO 2022231036 A1 WO2022231036 A1 WO 2022231036A1 KR 2021005454 W KR2021005454 W KR 2021005454W WO 2022231036 A1 WO2022231036 A1 WO 2022231036A1
Authority
WO
WIPO (PCT)
Prior art keywords
seq
amino acid
strain
acid sequence
glutamic acid
Prior art date
Application number
PCT/KR2021/005454
Other languages
English (en)
Korean (ko)
Inventor
권나라
이아름
봉현주
허란
유혜련
김비나
손성광
Original Assignee
씨제이제일제당 (주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 씨제이제일제당 (주) filed Critical 씨제이제일제당 (주)
Priority to PCT/KR2021/005454 priority Critical patent/WO2022231036A1/fr
Publication of WO2022231036A1 publication Critical patent/WO2022231036A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/14Glutamic acid; Glutamine

Abstract

La présente invention concerne un nouveau variant, une souche de Corynebacterium glutamicum comprenant ce variant et un procédé de production d'acide L-glutamique à l'aide de cette souche.
PCT/KR2021/005454 2021-04-29 2021-04-29 Nouveau variant et procédé de production d'acide l-glutamique l'utilisant WO2022231036A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/KR2021/005454 WO2022231036A1 (fr) 2021-04-29 2021-04-29 Nouveau variant et procédé de production d'acide l-glutamique l'utilisant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2021/005454 WO2022231036A1 (fr) 2021-04-29 2021-04-29 Nouveau variant et procédé de production d'acide l-glutamique l'utilisant

Publications (1)

Publication Number Publication Date
WO2022231036A1 true WO2022231036A1 (fr) 2022-11-03

Family

ID=83846953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/005454 WO2022231036A1 (fr) 2021-04-29 2021-04-29 Nouveau variant et procédé de production d'acide l-glutamique l'utilisant

Country Status (1)

Country Link
WO (1) WO2022231036A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4067484A4 (fr) * 2021-01-27 2024-01-24 Cj Cheiljedang Corp Nouveau variant de la galactoside o-acétyltransférase, et procédé de production d'acide l-glutamique faisant appel à

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060141588A1 (en) * 2004-12-28 2006-06-29 Jun Nakamura L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
KR100837844B1 (ko) * 2006-12-14 2008-06-13 씨제이제일제당 (주) L-글루탐산 생산능이 향상된 코리네박테리움 속 미생물 및이를 이용한 l-글루탐산 생산 방법
KR20110074521A (ko) * 2008-09-08 2011-06-30 아지노모토 가부시키가이샤 L-아미노산을 생산하는 미생물 및 l-아미노산의 제조법
KR20120046522A (ko) * 2010-11-02 2012-05-10 대상 주식회사 L?글루탐산 고생산능 코리네박테리움 글루타미쿰 변이 균주
KR102075160B1 (ko) * 2018-12-13 2020-02-10 대상 주식회사 L-글루탐산 생산능이 향상된 변이 균주 및 이를 이용한 l-글루탐산의 제조 방법
KR102254635B1 (ko) * 2021-01-27 2021-05-21 씨제이제일제당 주식회사 신규한 글루코사민-6-포스페이트 디아미나제 변이체 및 이를 이용한 l-글루탐산 생산 방법
KR102257842B1 (ko) * 2021-01-27 2021-05-28 씨제이제일제당 주식회사 신규한 d-알라닌-d-알라닌 리가아제 a 변이체 및 이를 이용한 l-글루탐산 생산 방법

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060141588A1 (en) * 2004-12-28 2006-06-29 Jun Nakamura L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
KR100837844B1 (ko) * 2006-12-14 2008-06-13 씨제이제일제당 (주) L-글루탐산 생산능이 향상된 코리네박테리움 속 미생물 및이를 이용한 l-글루탐산 생산 방법
KR20110074521A (ko) * 2008-09-08 2011-06-30 아지노모토 가부시키가이샤 L-아미노산을 생산하는 미생물 및 l-아미노산의 제조법
KR20120046522A (ko) * 2010-11-02 2012-05-10 대상 주식회사 L?글루탐산 고생산능 코리네박테리움 글루타미쿰 변이 균주
KR102075160B1 (ko) * 2018-12-13 2020-02-10 대상 주식회사 L-글루탐산 생산능이 향상된 변이 균주 및 이를 이용한 l-글루탐산의 제조 방법
KR102254635B1 (ko) * 2021-01-27 2021-05-21 씨제이제일제당 주식회사 신규한 글루코사민-6-포스페이트 디아미나제 변이체 및 이를 이용한 l-글루탐산 생산 방법
KR102257842B1 (ko) * 2021-01-27 2021-05-28 씨제이제일제당 주식회사 신규한 d-알라닌-d-알라닌 리가아제 a 변이체 및 이를 이용한 l-글루탐산 생산 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4067484A4 (fr) * 2021-01-27 2024-01-24 Cj Cheiljedang Corp Nouveau variant de la galactoside o-acétyltransférase, et procédé de production d'acide l-glutamique faisant appel à

Similar Documents

Publication Publication Date Title
WO2022163951A1 (fr) Nouveau variant de protéine et procédé de production de l-lysine l'utilisant
WO2019164348A1 (fr) Nouvelle protéine d'exportation de l-tryptophane et méthode de production de l-tryptophane l'utilisant
WO2020204427A1 (fr) Nouveau variant de protéine d'exportation de l-tryptophane et procédé de production de l-tryptophane l'utilisant
WO2021150029A1 (fr) Procédé de production d'acide l-aminé à l'aide d'un micro-organisme contenant de la glycéraldéhyde-3-phosphate déshydrogénase dépendante de nadp
WO2021049866A1 (fr) Variant de protéine d'exportation de l-thréonine et procédé de production de l-thréonine l'utilisant
WO2021125896A1 (fr) Mutant de protéine de membrane interne, et procédé de production d'un produit cible à l'aide de celui-ci
WO2017014532A1 (fr) Micro-organisme pour produire de la putrescine ou de l'ornithine, et procédé pour préparer de la putrescine ou de l'ornithine à l'aide de ce micro-organisme
WO2017069578A1 (fr) Microorganisme corynebacterium sp. présentant la capacité à produire de la l-isoleucine et procédé de production de l-isoleucine à l'aide de ce dernier
WO2021167414A1 (fr) Micro-organisme producteur de nucléotide de purine et procédé de production de nucléotide de purine l'utilisant
WO2021085999A1 (fr) Micro-organisme produisant de la l-méthionine dans lequel est introduite une protéine codée par un gène metz étranger et procédé de production de l-méthionine l'utilisant
WO2020226341A1 (fr) Micro-organisme produisant de l'acide l-aminé et procédé de production d'acide l-aminé à l'aide de celui-ci
WO2019164351A1 (fr) Micro-organisme producteur d'acides aminés de type mycosporine et procédé de production d'acides aminés de type mycosporine à l'aide de celui-ci
WO2022231036A1 (fr) Nouveau variant et procédé de production d'acide l-glutamique l'utilisant
WO2022225075A1 (fr) Nouveau variant et procédé de production de xmp ou de gmp l'utilisant
WO2021060696A1 (fr) Polypeptide modifié de dihydrodipicolinate réductase, et procédé de production de l-thréonine à l'aide de celui-ci
WO2019017706A2 (fr) Micro-organisme produisant de la putrescine et procédé de production de putrescine l'utilisant
WO2022164118A1 (fr) Variant de préphénate déshydratase et procédé de production d'un acide aminé à chaîne ramifiée l'utilisant
WO2021261733A1 (fr) Nouvelle l-thréonine déshydratase modifiée et procédé de production de l-isoleucine à l'aide de celle-ci
WO2022124708A1 (fr) Nouveau mutant aminotransférase d'acide aminé à chaîne ramifiée et procédé de production d'isoleucine faisant appel à celui-ci
WO2022231042A1 (fr) Nouveau variant et procédé de production de l-valine l'utilisant
WO2022191630A1 (fr) Nouveau variant de citrate synthase et procédé de production de l-valine l'utilisant
WO2022055094A1 (fr) Micro-organisme recombinant pour la production d'acide l-glutamique et procédé de production d'acide l-glutamique l'utilisant
WO2022050671A1 (fr) Micro-organismes produisant de la l-valine et procédé de production de l-valine les utilisant
WO2022163904A1 (fr) Nouveau variant de protéine et procédé de production de l-lysine l'utilisant
WO2022231037A1 (fr) Nouveau variant et procédé de production d'imp faisant appel à celui-ci

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21939419

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21939419

Country of ref document: EP

Kind code of ref document: A1