WO2022227467A1 - 生化分析仪 - Google Patents

生化分析仪 Download PDF

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Publication number
WO2022227467A1
WO2022227467A1 PCT/CN2021/128154 CN2021128154W WO2022227467A1 WO 2022227467 A1 WO2022227467 A1 WO 2022227467A1 CN 2021128154 W CN2021128154 W CN 2021128154W WO 2022227467 A1 WO2022227467 A1 WO 2022227467A1
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Prior art keywords
detection
disk
disc
optical path
biochemical analyzer
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PCT/CN2021/128154
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English (en)
French (fr)
Inventor
许行尚
陈杰弗瑞
鲁加勇
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南京岚煜生物科技有限公司
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Application filed by 南京岚煜生物科技有限公司 filed Critical 南京岚煜生物科技有限公司
Priority to US18/031,355 priority Critical patent/US20230273230A1/en
Priority to EP21938929.3A priority patent/EP4184172A4/en
Priority to KR1020237005309A priority patent/KR20230043886A/ko
Priority to JP2023512349A priority patent/JP7545180B2/ja
Publication of WO2022227467A1 publication Critical patent/WO2022227467A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0482—Transmission
    • G01N2035/0484—Belt or chain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes

Definitions

  • the invention belongs to the technical field of biochemical analysis and detection, in particular to a biochemical analyzer for detecting and analyzing chips.
  • a biochemical analyzer also often called a biochemical analyzer, is an instrument that uses the principle of photoelectric colorimetry to measure a specific chemical composition in body fluids. Because of its fast measurement speed, high accuracy and small consumption of reagents, it has been widely used in hospitals, epidemic prevention stations and family planning service stations at all levels. The combined use can greatly improve the efficiency and benefits of routine biochemical testing.
  • Chinese patent document CN111721952A discloses a biochemical analyzer and biochemical analysis method for biochemical analysis of a chip box, including an incubation tank module, including different operating stations arranged along a straight line for driving a disposable
  • the chip box of the test reagent moves along the operation station to perform biochemical detection; the operation mechanism is arranged beside the operation station to perform corresponding operations.
  • the incubation tank module includes an incubation tank with a straight channel inside; the top of the incubation tank is provided with a puncture position and a sample adding position connected to the straight channel at intervals along the direction of the straight channel; The side of the incubation tank is provided with a detection position that communicates with the straight channel, and the side wall of the chip box corresponding to the detection position can transmit light; one side of the straight channel is provided with a driving mechanism that can drive the chip box.
  • the invention provides a biochemical analyzer, which can solve the technical problem of simultaneous detection of multiple chips and improvement of detection efficiency.
  • the biochemical analyzer includes a detection disk sampling device, a detection disk device, an optical path detection device and a temperature control device, and the detection disk device includes a rotatable detection device.
  • the detection disk has several partitions, and each partition can be equipped with a corresponding chip to be detected; the detection disk is also provided with an optical limit slot, and the optical limit slot is located on the side of the detection disk.
  • a limit optocoupler cooperates to monitor the number of rotations of the detection disc.
  • Each partition of the inspection disk can be equipped with a chip to be inspected.
  • a rotatable inspection disk can be used to inspect multiple chips; The centrifugation process of the chip is precisely controlled; the detection disk sampling device is used for sample injection.
  • the detection disk sampling device is activated, the detection disk device extends out of the instrument, and the biochemical detection chip after sample addition is placed in the detection disk.
  • the detection disk sampling device starts and enters the detection instrument; the temperature control device controls the reaction temperature in the detection chamber of the instrument, and the optical path detection device detects the chip detection chamber and displays the detection result on the instrument display screen.
  • the detection disc is installed on the front and rear movement bracket of the detection disc, and a detection disc rotating motor is connected under the front and rear movement bracket of the detection disc;
  • the front and rear movement belts of the detection disc drive the front and rear movement brackets of the detection disc to move.
  • the front and rear movement bracket of the detection disc carries the detection disc and the detection disc rotating motor as a whole to move back and forth through the front and rear movement slide rails of the detection disc, which is optimized in structure and reasonable in layout; Yes, the driving mode of the belt connecting piece for the front and rear movement of the detection disc can be manual operation, motor or other driving methods.
  • the detection disc sample feeding device comprises a detection disc front and rear movement motor, and the detection disc front and rear movement motor drives the detection disc front and rear movement belt wound on the detection disc front and rear movement driving wheel and the detection disc front and rear movement driven wheel to move;
  • the front and rear movement belt connectors of the detection disc are arranged on the front and rear movement belts of the detection disc;
  • the front and rear movement brackets of the detection disc are provided with front and rear movement limit blocks of the detection disc, which cooperate with the front and rear movement limit optocouplers of the detection disc The forward and backward movement of the detection disc is limited.
  • a fan is further provided on the side of the front and rear moving bracket of the detection plate, and the fan cooperates with the temperature control device to control the reaction temperature of the detection chamber.
  • a second limit optocoupler is also provided on the side of the detection disk, and the second limit optocoupler cooperates with the code disk in the detection disk device.
  • the optical path detection device performs optical detection on the chip detection chamber.
  • the optical path detection device comprises an optical path detection transmitter assembly and an optical path detection receiver assembly; wherein, the optical path detection transmitter assembly is arranged in the optical path detection transmitter seat, and the optical path detection receiver assembly is arranged in the optical path detection receiver seat;
  • the optical path detection and emission component includes an emission light source, an emission lens and an emission circuit board, and the optical path detection and reception component includes an optical filter, a reception lens, a circuit board and a photocell.
  • the circuit board is connected with a temperature sensor; the temperature sensor ensures the accuracy of temperature control in the detection cavity.
  • the optical path detection receiving seat is located above the detection disk, and the optical path detection transmitting seat is located below the detection disk.
  • the structural layout of the optical path detection receiving seat and the optical path detection transmitting seat is convenient for the optical path detection of the chips located on the detection disk.
  • the biochemical analyzer is further provided with a detection cover, the temperature sensor is provided on the detection cover, and the detection cover is further provided with a cover plate; the optical path detection receiving seat is provided on the detection cover, located at The photocell of the optical path detection receiving seat is connected to the circuit board.
  • the detection cover and cover plate are used to protect and support other components located inside the biochemical analyzer to ensure normal detection.
  • the biochemical analyzer is further provided with a code scanner, the code scanner is located above the detection plate, scans the code of the chip to be detected on the detection plate and uploads the obtained information; the detection The side of the cover is also provided with a detector sampling baffle.
  • the code scanner scans the code of the biochemical detection chip, and the chip information, such as the test item, production batch number and other information, is uploaded and stored.
  • the detection disk device further includes a detection disk adapter block; the detection disk rotation motor is connected to the detection disk forward and backward movement bracket through a motor base, and the code disk is fixedly connected to the detection disk adapter block, The motor shaft of the rotating motor rotates with the detection disc; the detection disc adapter block is connected with the detection disc.
  • a magnet is arranged in the center of the detection disk adapter block, and the detection disk magnetic suction block is magnetically assembled with the magnet, and the cooperation of the two strengthens the connection strength of the detection disk and the detection disk adapter block. , so that the connection between the detection disc and the detection disc adapter block is more stable.
  • each partition in the detection disk is provided with a detection disk chip limit structure 1 at a position close to the center of the disk, and a detection disk chip limit structure 2 at a position far from the center of the disk.
  • the first bit structure and the second detection disk chip limit structure fix the chips to be detected in each partition.
  • FIG. 1 is a schematic diagram of the overall structure of a biochemical analyzer
  • Fig. 2 is the structural representation after removing the detection cover of the biochemical analyzer in Fig. 1;
  • Fig. 3 is the sectional structure schematic diagram of the biochemical analyzer in Fig. 1 after removing the detection cover and the cover plate;
  • Fig. 4 is the cross-sectional structure schematic diagram 1 of the biochemical analyzer in Fig. 1 after the cover plate is removed;
  • Fig. 5 is the sectional structure schematic diagram 2 of the biochemical analyzer in Fig. 1 after removing the cover plate;
  • FIG. 6 is a schematic structural diagram 1 of an optical path detection device
  • FIG. 7 is a schematic diagram of the exploded structure of the optical path detection transmitting assembly and the optical path detection receiving assembly of the optical path detection device in FIG. 6;
  • FIG. 8 is a second structural schematic diagram of an optical path detection device
  • FIG. 9 is a schematic diagram of the structure of the detection disc.
  • FIG. 10 is a schematic structural diagram of the assembly of the front and rear movement brackets of the detection disc and the front and rear movement limit blocks of the detection disc;
  • FIG. 11 is a schematic cross-sectional structure diagram of the detection disk device
  • FIG. 13 is a schematic diagram of the exploded structure of the detection disk device
  • 1-detection tray sample feeding device 101-detection tray front and rear movement bracket, 102-detection tray front and rear movement belt connector, 103-detection tray front and rear movement slider, 104-detection tray front and rear movement slide rail, 105-detection Front and rear motion motor of the disc, 106- detection disc front and rear movement driving wheel, 107- detection disc front and rear movement driven wheel, 108- detection disc front and rear movement belt, 109- detection disc front and rear movement limit block, 1010- detection disc front and rear movement limit Optocoupler, 1011-detector sampling baffle; 2-detection disc device, 201-detection disc, 202-optical limit slot, 203-limit optocoupler 1, 204-detection disc rotation motor, 205-limit light Coupling 2, 206-code disc, 207-detection disc adapter block, 208-motor base, 209-magnet, 2010-detection disc magnetic block, 2011
  • the biochemical analyzer of this embodiment includes a detection disc sample feeding device 1, a detection disc device 2, an optical path detection device 3 and a temperature control device 4.
  • the detection disc device 2 includes a rotatable detection device.
  • the disk 201, the detection disk 201 has three partitions (as shown in FIG. 9, other number of partitions can be set according to the size of the chip 10), and each partition can be equipped with a corresponding chip 10 to be tested; the detection disk 201 is also provided with There is an optical limiting slot 202 , and the optical limiting slot 202 cooperates with a limiting optocoupler 1 203 located on the side of the detection disc 201 to monitor the rotation times of the detection disc 201 .
  • the detection disc 201 is installed on the front and rear movement bracket 101 of the detection disc, and a detection disc rotating motor 204 is connected under the front and rear movement bracket 101 of the detection disc;
  • the front and rear movement belt connector 102 of the disc drives the movement of the front and rear movement bracket 101 of the detection disc, and the front and rear movement bracket 101 of the detection disc cooperates with the front and rear movement slider 103 of the detection disc to realize front and rear sliding; this embodiment Among them, there are two front and rear movement sliders 103 for the detection disc, which are connected to the support plate 9 , and the detection disc front and rear movement slide rails 104 are connected with the detection disc front and rear movement bracket 101 .
  • the detection disk sampling device 1 includes a detection disk front and rear motion motor 105, and the detection disk front and rear motion motor 105 drives the detection disk front and rear motion driving wheels 106 and the detection disk front and rear motion driven wheels 107.
  • the movement belt 108 moves; the front and rear movement belt connectors 102 of the detection disc are arranged on the front and rear movement belts 108 of the detection disc;
  • the optocoupler 1010 cooperates to limit the forward and backward movement of the detection disk 201 .
  • a fan 401 is also provided on the side of the front and rear moving bracket of the detection plate. As shown in FIGS. 3-5 and 10 , the fan 401 cooperates with the temperature control device 4 to control the reaction temperature of the detection chamber.
  • the second limit optocoupler 205 is also arranged on the side of the detection disk 201, and the second limit optocoupler 205 cooperates with the code disk 206 in the detection disk device 2.
  • the optical path detection device 3 Perform optical detection on the chip detection chamber.
  • the optical path detection device 3 includes an optical path detection transmitter assembly 301 and an optical path detection receiver assembly 302; wherein the optical path detection transmitter assembly 301 is arranged in the optical path detection transmitter base 303, and the optical path detection receiver assembly 302 is arranged in the optical path detection In the receiving seat 304; the optical path detection and emission component 301 includes an emission light source 305, an emission lens 306 and an emission circuit board 307, and the optical path detection receiving component 302 includes an optical filter 308, a receiving lens 309, a circuit board 7 and a photocell 3010, on the circuit board 7 A temperature sensor 402 is also connected; it should be noted that in this embodiment, there are 5 groups of optical path detection components (optical path detection transmitting components, optical path detection receiving components), which can detect optical paths of 5 different wavelengths; the circuit board 7 not only It is used as a circuit board in the optical path detection receiving assembly (the circuit board in the optical path detection receiving assembly is only a part of its functions), it is also the main circuit board of the
  • the optical path detection receiving seat 304 is located above the detection disk 201 , and the optical path detection transmitting seat 303 is located below the detection disk 201 .
  • the biochemical analyzer of this embodiment is further provided with a detection cover 5.
  • a temperature sensor 402 is provided on the detection cover 5, and the detection cover 5 also has a cover plate 6;
  • the photocell 3010 located in the optical path detection receiving seat 304 is connected to the circuit board 7, the temperature control device 4 is installed under the detection cover 5, specifically below the support plate 9, and the front and rear motion motor 105 of the detection plate is also on the support plate.
  • the front and rear movement driving wheel 106 of the detection disc and the front and rear movement driven wheel 107 of the detection disc are both located on the top of the support plate 9, and the structure layout is reasonable, saving the space of the analyzer.
  • the biochemical analyzer is also provided with a barcode scanner 8 (a barcode scanner housing can also be set outside, which is arranged on the detection cover 5 to support and fix the barcode scanner 8), as shown in Figures 1, 4 and 5,
  • the code scanner 8 is located above the detection plate 201, the circuit board 7 is provided with a mounting through hole structure, and the code scanner 8 is installed in this through hole, so that the code scanner 8 can pass through the circuit board 7 to the waiting on the detection plate 201.
  • the detection chip 10 scans the code and uploads the obtained information, and the chip information such as the detection item, production batch number and other information is uploaded and stored;
  • the detection disk device 2 further includes a detection disk adapter block 207; the detection disk rotation motor 204 is connected to the detection disk forward and backward movement bracket 101 through the motor base 208, and the code disk 206 is connected to the detection disk adapter block 207 is fixedly connected, and rotates with the motor shaft of the detection disk rotating motor 204; the detection disk adapter block 207 is connected with the detection disk 201, the center of the detection disk adapter block 207 is provided with a magnet 209, and the detection disk magnetic suction block 2010 and the magnet 209 Magnetic assembly is performed to make the connection between the detection disk 201 and the detection disk adapter block 207 more stable.
  • Each partition in the test disk 201 is provided with a test disk chip limit structure 1 2011 at a position close to the center of the disk, and a test disk chip limit structure 2 2012 at a position far from the center of the disk.
  • the second 2012 and the detection disk chip limit structure fix the to-be-detected chip 10 in each partition, as shown in Figs.
  • the detection disk 201 in this embodiment is divided into three sector-shaped partitions.
  • the detection disk sampling device 1 starts up, the detection disk device 2 extends out of the instrument, and after the biochemical detection chip 10 after sample addition is put into the detection disk 201, the detection disk sampling device 1 starts again and enters the biochemical analysis instrument.
  • the temperature control device 4 controls the reaction temperature in the detection chamber of the instrument, and the temperature sensor 402 ensures the accuracy of temperature control in the detection chamber; Chip information, such as test items, production batch numbers, etc., are uploaded to the instrument; the test disk device 2 is set according to the control program, and the test disk rotating motor 204 drives the test disk 201 to perform operations such as rotation, centrifugation, and mixing to complete the reaction process; finally, the optical path
  • the detection device 3 is activated to detect the chip detection chamber, and the detection result is displayed on the display screen of the biochemical analyzer.

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Abstract

本发明公开了一种生化分析仪，该生化分析仪，包括有检测盘进样装置、检测盘装置、光路检测装置和温度控制装置，所述检测盘装置包括有可旋转的检测盘，所述检测盘具有若干个分区，每个分区可对应配装一个待检测芯片；所述检测盘上还设置有光学限位槽，所述光学限位槽与位于所述检测盘侧面的限位光耦一配合监测所述检测盘的旋转次数。检测盘的每个分区都可以配装一个待检测芯片，一次操作，采用可旋转的检测盘，可对多个芯片进行检测；另外，光学限位槽监测所述检测盘的旋转次数，使检测时的芯片离心过程得到精确控制，能够解决多个芯片同时检测，提高检测效率的技术问题。

Description

生化分析仪 技术领域
本发明属于生化分析检测技术领域，尤其是涉及一种对芯片进行检测分析的生化分析仪。
背景技术
生化分析仪又常被称为生化仪，是采用光电比色原理来测量体液中某种特定化学成分的仪器。由于其测量速度快、准确性高、消耗试剂量小，现已在各级医院、防疫站、计划生育服务站得到广泛使用。配合使用可大大提高常规生化检验的效率及收益。
自美国Technicon公司于1957年成功地生产了世界上第一台全自动生化分析仪后，各种型号和功能不同的全自动生化分析仪不断涌现，为医院临床生化检验的自动化迈出了十分重要的一步。自50年代skeggs首次介绍一种临床生化分析仪的原理以来，随着科学技术尤其是医学科学的发展，各种生化自动分析仪和诊断试剂均有了很大发展，根据仪器的结构原理不同，可分为：连续流动式(管道式)、分立式、分离式和干片式四类。
在中国专利文献CN111721952A中公开了一种针对芯片盒进行生化分析的生化分析仪及生化分析方法，包括温育槽模组，包括沿直线设置的不同操作工位，用于驱动内封有一次性测试试剂的芯片盒沿所述操作工位运动以进行生化检测；操作机构，布局在所述操作工位旁以进行对应操作。所述温育槽模组包括内部具有直线通道的温育槽；所述温育槽的上面沿所述直线通道方向间隔设有与所述直线通道连通的穿刺位和加样位；所述温育槽的侧面设有与所述直线通道连通的检测位，对应所述检测位的所述芯片盒侧壁可透光；所述直线通道的一侧设置可驱动所述芯片盒的驱动机构。
上述技术方案的生化分析实际使用过程中效果不是很理想，芯片检测效率太低，不能一次性操作检测多个芯片。
发明内容
本发明提供一种生化分析仪，能够解决多个芯片同时检测，提高检测效率的技术问题。
为解决上述技术问题，本发明采用的技术方案是，该生化分析仪，包括有检测盘进样装置、检测盘装置、光路检测装置和温度控制装置，所述检测盘装置包括有可旋转的检测盘，所述检测盘具有若干个分区，每个分区可对应配装一个待检测芯片；所述检测盘上还设置有光学限位槽，所述光学限位槽与位于所述检测盘侧面的限位光耦一配合监测所述检测盘的旋转次数。
检测盘的每个分区都可以配装一个待检测芯片，一次操作，采用可旋转的检测盘，可对多个芯片进行检测；另外，光学限位槽监测所述检测盘的旋转次数，使检测时的芯片离心过程得到精确控制；检测盘进样装置用于进样，检测开始时，检测盘进样装置启动，检测盘装置伸出仪器，将加样后的生化检测芯片放入检测盘后，检测盘进样装置启动，进入检测仪器中；温度控制装置控制仪器检测腔内反应温度，光路检测装置对芯片检测室进行检测，将检测结果显示在仪器显示屏上。
优选的，所述检测盘安装在检测盘前后运动托架上，在所述检测盘前后运动托架下方连接有检测盘旋转电机；所述检测盘前后运动托架连接有检测盘前后运动皮带连接件，所述检测盘前后运动皮带连接件带动所述检测盘前后运动托架动作，所述检测盘前后运动托架通过检测盘前后运动滑轨与检测盘前后运动滑块配合实现前后滑动。
采用上述结构的生化分析仪，检测盘前后运动托架带着检测盘和检测盘旋转电机整体通过检测盘前后运动滑轨进行前后运动，在结构上进行了优化，布局合理；另外在此说明的是，检测盘前后运动皮带连接件驱动方式可以是手动操作也可以是电机或者其他方式驱动。
优选的，所述检测盘进样装置包括有检测盘前后运动电机，所述检测盘前后运动电机驱动缠绕在检测盘前后运动主动轮和检测盘前后运动从动轮上的检测盘前后运动皮带运动；所述检测盘前后运动皮带连接件设置在所述检测盘前后运动皮带上；所述检测盘前后运动托架侧面设置有检测盘前后运动限位挡片，与检测盘前后运动限位光耦配合对所述检测盘的前后运动进行限位。
优选的，在所述检测盘前后运动托架的侧面还设置有风扇，所述风扇配合所述温度控制装置控制检测腔的反应温度。
优选的，位于所述检测盘侧面还设置有限位光耦二，所述限位光耦二与所述 检测盘装置中的码盘配合，当所述限位光耦二检测到所述码盘间隔区，所述光路检测装置对芯片检测室进行光学检测。
优选的，所述光路检测装置包括光路检测发射组件与光路检测接收组件；其中，所述光路检测发射组件设置在光路检测发射座中，所述光路检测接收组件设置在光路检测接收座中；所述光路检测发射组件包括发射光源、发射透镜和发射电路板，所述光路检测接收组件包括滤光片、接收透镜、电路板和光电池。
优选的，所述电路板连接有温度传感器；温度传感器保证检测腔内温度控制精确性。
优选的，所述光路检测接收座位于所述检测盘上方，所述光路检测发射座位于所述检测盘下方。
光路检测接收座和光路检测发射座的这种结构布局，便于对位于检测盘上的芯片进行光路检测。
优选的，该生化分析仪还设置有检测罩，所述温度传感器设置在所述检测罩上，所述检测罩上还具有盖板；所述光路检测接收座设置在所述检测罩上，位于所述光路检测接收座的所述光电池与所述电路板连接。
检测罩、盖板用于对位于生化分析仪内部的其他部件起到防护、支撑作用，保证检测的正常进行。
优选的，该生化分析仪还设置有扫码器，所述扫码器位于所述检测盘上方，对处于所述检测盘上的待检测芯片进行扫码并将得到的信息上传；所述检测罩的侧面还设置有检测仪进样挡板。
扫码器对生化检测芯片进行扫码，芯片信息，如检测项目、生产批号等信息进行上传存储。
优选的，所述检测盘装置还包括有检测盘适配块；所述检测盘旋转电机通过电机座与检测盘前后运动托架连接，所述码盘与所述检测盘适配块固定连接，随所述检测盘旋转电机的电机轴进行旋转；所述检测盘适配块与所述检测盘连接。
优选的，所述检测盘适配块的中央配置有磁铁，检测盘磁吸块与所述磁铁进行磁性配装，二者配合强化了所述检测盘与所述检测盘适配块的连接强度，使得所述检测盘与所述检测盘适配块连接更加稳定。
优选的，所述检测盘中每个分区在靠近盘中心位置处设置有检测盘芯片限位 结构一，在远离盘中心位置处设置有检测盘芯片限位结构二，通过所述检测盘芯片限位结构一和检测盘芯片限位结构二将待检测芯片固定在每个分区内。
附图说明
下面结合附图和本发明的实施方式进一步详细说明：
图1是生化分析仪整体结构示意图；
图2是图1中的生化分析仪去掉检测罩后的结构示意图；
图3是图1中的生化分析仪去掉检测罩、盖板后的剖面结构示意图；
图4是图1中的生化分析仪去掉盖板后的剖面结构示意图一；
图5是图1中的生化分析仪去掉盖板后的剖面结构示意图二；
图6是光路检测装置的结构示意图一；
图7是图6中光路检测装置的光路检测发射组件与光路检测接收组件分解结构示意图；
图8是光路检测装置的结构示意图二；
图9是检测盘结构示意图；
图10是检测盘前后运动托架与检测盘前后运动限位挡片配装的结构示意图；
图11是检测盘装置的剖面结构示意图；
图12是检测盘装置的结构示意图；
图13是检测盘装置的分解结构示意图；
其中：1-检测盘进样装置，101-检测盘前后运动托架，102-检测盘前后运动皮带连接件，103-检测盘前后运动滑块，104-检测盘前后运动滑轨，105-检测盘前后运动电机，106-检测盘前后运动主动轮，107-检测盘前后运动从动轮，108-检测盘前后运动皮带，109-检测盘前后运动限位挡片，1010-检测盘前后运动限位光耦，1011-检测仪进样挡板；2-检测盘装置，201-检测盘，202-光学限位槽，203-限位光耦一，204-检测盘旋转电机，205-限位光耦二，206-码盘，207-检测盘适配块，208-电机座，209-磁铁，2010-检测盘磁吸块，2011-检测盘芯片限位结构一，2012-检测盘芯片限位结构二；3-光路检测装置，301-光路检测发射组件，302-光路检测接收组件，303-光路检测发射座，304-光路检测接收座，305-发射光源，306-发射透镜，307-发射电路板，308-滤光片，309-接收透镜，3010-光电池；4-温度控制装置，401-风扇，402-温度传感器；5-检测罩；6-盖板；7-电路板； 8-扫码器；9-支持板；10-芯片，1001-芯片扫码区。
具体实施方式
如图1～13所示，本实施例的生化分析仪，包括有检测盘进样装置1、检测盘装置2、光路检测装置3和温度控制装置4，检测盘装置2包括有可旋转的检测盘201，检测盘201具有三个分区(如图9所示，根据芯片10的尺寸还可以设置其他数量的分区)，每个分区可对应配装一个待检测芯片10；检测盘201上还设置有光学限位槽202，光学限位槽202与位于检测盘201侧面的限位光耦一203配合监测检测盘201的旋转次数。
检测盘201安装在检测盘前后运动托架101上，在检测盘前后运动托架101下方连接有检测盘旋转电机204；检测盘前后运动托架101连接有检测盘前后运动皮带连接件102，检测盘前后运动皮带连接件102带动所述检测盘前后运动托架101动作，检测盘前后运动托架101通过检测盘前后运动滑轨104与检测盘前后运动滑块103配合实现前后滑动；本实施例中，检测盘前后运动滑块103有两个，连接在支持板9上，检测盘前后运动滑轨104与检测盘前后运动托架101连接。
如图2所示，检测盘进样装置1包括有检测盘前后运动电机105，检测盘前后运动电机105驱动缠绕在检测盘前后运动主动轮106和检测盘前后运动从动轮107上的检测盘前后运动皮带108运动；检测盘前后运动皮带连接件102设置在检测盘前后运动皮带108上；检测盘前后运动托架101侧面设置有检测盘前后运动限位挡片109，与检测盘前后运动限位光耦1010配合对检测盘201的前后运动进行限位。
在所述检测盘前后运动托架的侧面还设置有风扇401，如图3-5、10所示，风扇401配合温度控制装置4控制检测腔的反应温度。
位于检测盘201侧面还设置有限位光耦二205，限位光耦二205与检测盘装置2中的码盘206配合，当限位光耦二205检测到码盘206间隔区，光路检测装置3对芯片检测室进行光学检测。
如图6-8所示，光路检测装置3包括光路检测发射组件301与光路检测接收组件302；其中，光路检测发射组件301设置在光路检测发射座303中，光路检测接收组件302设置在光路检测接收座304中；光路检测发射组件301包括发射 光源305、发射透镜306和发射电路板307，光路检测接收组件302包括滤光片308、接收透镜309、电路板7和光电池3010，电路板7上还连接有温度传感器402；需要注意的是，在本实施例中，具有5组光路检测组件(光路检测发射组件、光路检测接收组件)，可以检测5种不同波长的光路；电路板7不仅仅是作为光路检测接收组件中的电路板(作为光路检测接收组件中的电路板仅是其需要实现的一部分功能)，它还是本实施例的生化分析仪的主电路板，附加有其他电路结构在上面，实现更多的其他功能，这种结构设置更加简约，布局紧凑。
光路检测接收座304位于所述检测盘201上方，光路检测发射座303位于所述检测盘201下方。
本实施例的生化分析仪还设置有检测罩5，如图1所示，温度传感器402设置在所述检测罩5上，检测罩5上还具有盖板6；光路检测接收座304设置在检测罩5上，位于光路检测接收座304的光电池3010与电路板7连接，温度控制装置4安装在检测罩5的下方，具体在支持板9的下面，且检测盘前后运动电机105也是在支持板9的下面，检测盘前后运动主动轮106和检测盘前后运动从动轮107均处于支持板9的上面，结构布局合理，节约分析仪的空间。
该生化分析仪还设置有扫码器8(外面还可以设置一个扫码器外壳，设置在检测罩5上，用于支持、固定扫码器8)，如图1、4和5所示，扫码器8位于检测盘201上方，电路板7设置一个安装通孔结构，扫码器8安装在这个通孔内，使得扫码器8可以透过电路板7对处于检测盘201上的待检测芯片10进行扫码并将得到的信息上传，芯片信息如检测项目、生产批号等信息进行上传存储；检测罩5的侧面还设置有检测仪进样挡板1011，如图1所示。
如图9-13所示，检测盘装置2还包括有检测盘适配块207；检测盘旋转电机204通过电机座208与检测盘前后运动托架101连接，码盘206与检测盘适配块207固定连接，随检测盘旋转电机204的电机轴进行旋转；检测盘适配块207与检测盘201连接，检测盘适配块207的中央配置有磁铁209，检测盘磁吸块2010与磁铁209进行磁性配装，使得检测盘201与检测盘适配块207连接更加稳定，按照图13的分解顺序依次配装，检测盘磁吸块2010在检测盘201的中央位置。
检测盘201中每个分区在靠近盘中心位置处设置有检测盘芯片限位结构一2011，在远离盘中心位置处设置有检测盘芯片限位结构二2012，通过检测盘芯 片限位结构一2011和检测盘芯片限位结构二2012将待检测芯片10固定在每个分区内，如图9、13所示，尤其是图13，本实施例中的芯片10为扇形，与检测盘201的扇形分区相对应，本实施例的检测盘201分为三个扇形分区。
检测开始时，检测盘进样装置1启动，检测盘装置2伸出仪器，将加样后的生化检测芯片10放入检测盘201后，检测盘进样装置1再次启动，进入生化分析仪器中；温度控制装置4控制仪器检测腔内反应温度，温度传感器402保证检测腔内温度控制精确性；扫码器8对位于检测盘201上的生化检测芯片10的芯片扫码区1001进行扫码，芯片信息，如检测项目、生产批号等信息上传到仪器中；检测盘装置2按照控制程序设置，检测盘旋转电机204驱动检测盘201进行旋转离心、混匀等操作，完成反应过程；最后，光路检测装置3启动，对芯片检测室进行检测，检测结果显示在生化分析仪的显示屏。
以上显示和描述了本发明的基本原理、主要特征及优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (13)

  1. 一种生化分析仪，包括有检测盘进样装置、检测盘装置、光路检测装置和温度控制装置，其特征在于，所述检测盘装置包括有可旋转的检测盘，所述检测盘具有若干个分区，每个分区可对应配装一个待检测芯片；所述检测盘上还设置有光学限位槽，所述光学限位槽与位于所述检测盘侧面的限位光耦一配合监测所述检测盘的旋转次数。
  2. 根据权利要求1所述的生化分析仪，其特征在于，所述检测盘安装在检测盘前后运动托架上，在所述检测盘前后运动托架下方连接有检测盘旋转电机；所述检测盘前后运动托架连接有检测盘前后运动皮带连接件，所述检测盘前后运动皮带连接件带动所述检测盘前后运动托架动作，所述检测盘前后运动托架通过检测盘前后运动滑轨与检测盘前后运动滑块配合实现前后滑动。
  3. 根据权利要求2所述的生化分析仪，其特征在于，所述检测盘进样装置包括有检测盘前后运动电机，所述检测盘前后运动电机驱动缠绕在检测盘前后运动主动轮和检测盘前后运动从动轮上的检测盘前后运动皮带运动；所述检测盘前后运动皮带连接件设置在所述检测盘前后运动皮带上；所述检测盘前后运动托架侧面设置有检测盘前后运动限位挡片，与检测盘前后运动限位光耦配合对所述检测盘的前后运动进行限位。
  4. 根据权利要求3所述的生化分析仪，其特征在于，在所述检测盘前后运动托架的侧面还设置有风扇，所述风扇配合所述温度控制装置控制检测腔的反应温度。
  5. 根据权利要求4所述的生化分析仪，其特征在于，位于所述检测盘侧面还设置有限位光耦二，所述限位光耦二与所述检测盘装置中的码盘配合，当所述限位光耦二检测到所述码盘间隔区，所述光路检测装置对芯片检测室进行光学检测。
  6. 根据权利要求5所述的生化分析仪，其特征在于，所述光路检测装置包括光路检测发射组件与光路检测接收组件；其中，所述光路检测发射组件设置在光路检测发射座中，所述光路检测接收组件设置在光路检测接收座中；所述光路检测发射组件包括发射光源、发射透镜和发射电路板，所述光路检测接收组件包括滤光片、接收透镜、电路板和光电池。
  7. 根据权利要求6所述的生化分析仪，其特征在于，所述电路板连接有温度传 感器。
  8. 根据权利要求5或6所述的生化分析仪，其特征在于，所述光路检测接收座位于所述检测盘上方，所述光路检测发射座位于所述检测盘下方。
  9. 根据权利要求7所述的生化分析仪，其特征在于，该生化分析仪还设置有检测罩，所述温度传感器设置在所述检测罩上，所述检测罩上还具有盖板；所述光路检测接收座设置在所述检测罩上，位于所述光路检测接收座的所述光电池与所述电路板连接。
  10. 根据权利要求9所述的生化分析仪，其特征在于，该生化分析仪还设置有扫码器，所述扫码器位于所述检测盘上方，对处于所述检测盘上的待检测芯片进行扫码并将得到的信息上传。
  11. 根据权利要求5所述的生化分析仪，其特征在于，所述检测盘装置还包括有检测盘适配块；所述检测盘旋转电机通过电机座与检测盘前后运动托架连接，所述码盘与所述检测盘适配块固定连接，随所述检测盘旋转电机的电机轴进行旋转；所述检测盘适配块与所述检测盘连接。
  12. 根据权利要求11所述的生化分析仪，其特征在于，所述检测盘适配块的中央配置有磁铁，检测盘磁吸块与所述磁铁进行磁性配装。
  13. 根据权利要求1所述的生化分析仪，其特征在于，所述检测盘中每个分区在靠近盘中心位置处设置有检测盘芯片限位结构一，在远离盘中心位置处设置有检测盘芯片限位结构二，通过所述检测盘芯片限位结构一和检测盘芯片限位结构二将待检测芯片固定在每个分区内。
PCT/CN2021/128154 2021-04-30 2021-11-02 生化分析仪 WO2022227467A1 (zh)

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