WO2022225218A1 - Dispositif de thérapie laser de faible niveau utilisant un capuchon d'endoscope à led - Google Patents

Dispositif de thérapie laser de faible niveau utilisant un capuchon d'endoscope à led Download PDF

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Publication number
WO2022225218A1
WO2022225218A1 PCT/KR2022/004465 KR2022004465W WO2022225218A1 WO 2022225218 A1 WO2022225218 A1 WO 2022225218A1 KR 2022004465 W KR2022004465 W KR 2022004465W WO 2022225218 A1 WO2022225218 A1 WO 2022225218A1
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WIPO (PCT)
Prior art keywords
led
endoscope cap
hood
treatment device
duodenum
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PCT/KR2022/004465
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English (en)
Korean (ko)
Inventor
박도현
권진희
Original Assignee
재단법인 아산사회복지재단
울산대학교 산학협력단
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Application filed by 재단법인 아산사회복지재단, 울산대학교 산학협력단 filed Critical 재단법인 아산사회복지재단
Priority to EP22791918.0A priority Critical patent/EP4327863A4/fr
Priority to US18/556,360 priority patent/US20240342504A1/en
Priority to JP2023564138A priority patent/JP2024515102A/ja
Publication of WO2022225218A1 publication Critical patent/WO2022225218A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00131—Accessories for endoscopes
    • A61B1/00137—End pieces at either end of the endoscope, e.g. caps, seals or forceps plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0625—Warming the body, e.g. hyperthermia treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00494—Stomach, intestines or bowel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0609—Stomach and/or esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0653—Organic light emitting diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details

Definitions

  • the present invention relates to a low-level laser treatment device using an LED endoscope cap.
  • the duodenum is the site of increased secretion of type 2 diabetes/nonalcoholic fatty liver-related hormones (eg GIP) during abnormal mucosal thickening in patients with type 2 diabetes. It is a key position in treatment.
  • GIP nonalcoholic fatty liver-related hormones
  • GIP is secreted from the K-cells of the duodenum and pancreas. Stimulation of K-cells through phototherapy improves the dysfunction of mitochondria in cells, and through this, it regulates GIP secretion to treat type 2 diabetes, obesity, and nonalcoholic fatty liver. It can be prevented.
  • duodenal mucosal resurfacing using a high-frequency lamp can be applied.
  • radiofrequency treatment using such heat may cause stenosis, perforation, and bleeding of the duodenum.
  • the phototherapy method using a low-level laser improves the mitochondrial function of abnormal cells by irradiating light on the duodenum surface, suppresses the function of K cells by increasing ATP production, regeneration of normal duodenal and pancreatic cells, and improving the environment of intestinal bacteria in the duodenum. It has properties that can cure diabetes.
  • this phototherapy method since this phototherapy method must be performed by inserting a catheter such as an endoscope into the patient's body, there is a risk of damaging the internal organs or mucous membranes of the patient by the catheter or the cap coupled to the outside of the catheter in the process. .
  • a light source such as an LED is in contact with the surface of the duodenum as wide as possible.
  • An object of the present invention is to provide a laser treatment device in which a light source can be in wide contact with surfaces such as intestines without damaging the surface or mucous membrane of a patient's organs.
  • Another object of the present invention is to provide a laser treatment device capable of irradiating light of different wavelengths to the duodenum and the pancreas of a patient.
  • one aspect of the present invention is a catheter formed to extend to be inserted into the body of a patient and provided with a sending unit for straightening the mucosal folds of the duodenum of the patient, a through hole penetrating the inside so that the catheter is interpolated It may include a provided endoscope cap, a hood disposed in an outer region of the endoscope cap, at least one region protruding toward the front of the endoscope cap, and at least one LED disposed in each of the endoscope cap and the hood .
  • the present invention can provide a laser treatment device in which a light source can be in wide contact with a surface, such as an intestine, without damaging the surface or mucous membrane of a patient's organs.
  • the present invention may provide a laser treatment device capable of irradiating light of different wavelengths to the duodenum and the pancreas of a patient.
  • 1 is a diagram showing experimental results comparing blood glucose levels in diabetic rats with and without LED treatment.
  • Figure 2 is a diagram schematically showing a low-level laser treatment device using an LED endoscope cap according to an embodiment of the present invention.
  • FIG. 3 is a diagram schematically illustrating an embodiment of the body of FIG. 2 .
  • Figure 4 (a) is a view of the main body of Figure 2 viewed from below
  • Figure 4 (b) is a view of the main body of Figure 2 viewed from above.
  • 5 is a view for explaining the light emitted by the LEDs.
  • FIG. 6 is a view for explaining an example of use of the low-level laser treatment device using the LED endoscope cap according to the present invention.
  • FIG. 7 is an enlarged view of X of FIG. 3 .
  • FIG. 8 is a side view of the low-level laser treatment device using the LED endoscope cap of FIG. 2 .
  • FIG. 9 is a view illustrating an embodiment of the hood of FIG. 3 .
  • FIG. 10 is a view showing another embodiment of the hood of FIG.
  • 11 is a view for explaining the inside of the main body.
  • one aspect of the present invention is a catheter formed to extend to be inserted into the body of a patient and provided with a sending unit for straightening the mucosal folds of the duodenum of the patient, a through hole penetrating the inside so that the catheter is interpolated It may include a provided endoscope cap, a hood disposed in an outer region of the endoscope cap, at least one region protruding toward the front of the endoscope cap, and at least one LED disposed in each of the endoscope cap and the hood .
  • the hood may be formed in a joint structure.
  • the hood may include a curved region formed in a curved surface at one end.
  • a first LED irradiating a first light in a first wavelength band is disposed on the surface of the endoscope cap, and a second LED irradiating a second light in a second wavelength band different from the first wavelength band is disposed on the surface of the hood.
  • the first wavelength band may be a predetermined wavelength band between 600 and 700 nm
  • the second wavelength band may be a predetermined wavelength band between 800 and 900 nm.
  • the hood may be movable such that at least one area forms a predetermined angle from the endoscope cap.
  • a band having a smaller diameter than the diameter of the through hole may be inserted into the through hole.
  • the LED may include at least one of a quantum dot LED and a flexible OLED using quantum dots as a light source.
  • the x-axis, the y-axis, and the z-axis are not limited to three axes on the Cartesian coordinate system, and may be interpreted in a broad sense including them.
  • the x-axis, y-axis, and z-axis may be orthogonal to each other, but may refer to different directions that are not orthogonal to each other.
  • a specific process sequence may be performed different from the described sequence.
  • two processes described in succession may be performed substantially simultaneously, or may be performed in an order opposite to the order described.
  • Intestinal bacteria that are harmful to the human body reduce short-chain fatty acids in the body, thereby damaging the duodenal mucosa, whereby metabolites made from intestinal bacteria harmful to the human body spread through the bloodstream throughout the body, causing metabolic diseases
  • the present invention can provide a photobiomodulation treatment function through LED.
  • the present invention inhibits the growth of intestinal bacteria (clostridium, etc.) harmful to the human body by photobiomodulation of the microbiome in the duodenum, and implantation of useful intestinal bacteria (Bifidobacterium and Lactobacillus, etc.) in the duodenum ( photo microbiota transplant (PMT). Therefore, through the effect of improving the mucous membrane and intestinal bacterial environment of the duodenum, the effect of treating metabolic diseases including type 2 diabetes and fatty liver, and neurological diseases such as dementia caused by the intestinal bacterial imbalance of the duodenum microbiome, and heart and cancer diseases There is an effect that can be done.
  • intestinal bacteria clostridium, etc.
  • PMT photo microbiota transplant
  • the present invention has the effect of reducing harmful bacteria in a patient's duodenum and increasing beneficial bacteria through PMT.
  • 1 is a diagram showing experimental results comparing blood glucose levels in diabetic rats with and without LED treatment.
  • FIG. 2 is a view schematically showing a laser treatment device 10 according to an embodiment of the present invention.
  • the laser treatment device 10 may include a body 100 , a catheter 200 , and a battery 300 .
  • the catheter 200 may be a means to be inserted into the body of a patient.
  • the catheter 200 may be an endoscope tube formed of a flexible material.
  • the catheter 200 may be in the shape of a tube having a circular cross-section.
  • the catheter 200 may be in the shape of a tube having a polygonal cross-section.
  • An endoscope cap 110 may be connected to one side of the catheter 200 as will be described later.
  • the catheter 200 may be inserted into the through hole 111 formed in the endoscope cap 110 .
  • the catheter 200 may guide the movement of the endoscope cap 110 while being inserted into the patient's body. That is, when the catheter 200 is inserted into the patient, the endoscope cap 110 connected to one side of the catheter 200 moves together, so that the endoscope cap 110 can guide the path of movement inside the patient's body. .
  • the catheter 200 may be inserted into the user's duodenum.
  • the battery 300 may be a medical battery, and the laser treatment device 10 may receive power for laser treatment therefrom.
  • the laser treatment device 10 may receive power required for light irradiation from a medical high-frequency generator or a low-output power generator in a form coupled to the end of the body.
  • the laser treatment device 10 may perform laser treatment.
  • the laser treatment device 10 may perform low-level laser treatment.
  • medical high-frequency current may be directly supplied to the laser treatment device 10, and for this purpose, the laser treatment device 10 as an embodiment changes the variable resistance at the end of the body. It may further include a possible configuration. For example, by increasing the variable resistance of the external end portion of the laser treatment device 10, the high-frequency current can be converted into a current having a size suitable for low-level laser treatment.
  • the laser treatment device 10 may further include a rechargeable battery at the other end, and the rechargeable battery may be capable of charging the rapid power supply 300 using energy supplied from the above-described battery, for example, a medical high frequency generator. have.
  • the laser treatment device 10 may be maintained in a preliminary mode until an appropriate power is supplied, and when an appropriate power is supplied, it may be changed to a surgical mode by the operator.
  • the laser treatment device 10 may include a switch for changing the preliminary mode to the operation mode.
  • the switch may be a pedal, a button, or a rotary switch.
  • the present invention is not limited thereto.
  • the irradiation of the laser of the laser treatment device 10 may be a pulse mode, it may be a continuous irradiation mode.
  • the light irradiated from the laser treatment device 10 may be a light with a change in intensity so as to have a cycle, a light in which irradiation and stopping are periodically repeated, or a light that is continuously irradiated.
  • the laser treatment device 10 may further include a timer for controlling the laser treatment time.
  • FIG. 3 is a diagram schematically illustrating an embodiment of the body 100 of FIG. 2 .
  • the body 100 may include an endoscope cap 110 and a hood 120 .
  • the laser treatment device is formed to extend to be inserted into the patient's body, the catheter 200 having a sending unit, the catheter 200 is an endoscope provided with a through hole 111 penetrating the inside to be interpolated.
  • the cap 110, the hood 120 and the endoscope cap 110 and the hood disposed in one area outside the endoscope cap 110, at least one area is disposed to protrude forward than the endoscope cap 110 120 may include at least one LED disposed on each.
  • the catheter 200 may be a means to be inserted into the body of a patient.
  • the catheter 200 may include a ventilation unit.
  • the sending unit may be a means for straightening the duodenal mucosal folds through air insufflation from the inside of the duodenum of the patient, for example, it may be a means for straightening the duodenal mucosal folds in the area where the laser treatment device 10 is in contact. . For this reason, light can be irradiated to a large area of the duodenal mucosa spread through the air supply unit, so that light irradiation efficiency can be improved.
  • the air sending unit can improve the effect of the light source by stretching the folds of the duodenal mucosa, and specifically, when the light source used for light irradiation is a surface light source, the effect of the surface light source can be maximized.
  • the endoscope cap 110 may be a means for the catheter 200 to be inserted.
  • the endoscope cap 110 may include a through hole 111 provided to penetrate through the interior so that the catheter 200 is interpolated.
  • the through hole 111 may be formed in the interior of the endoscope cap 110 to have a length such that the catheter 200 is interpolated. Accordingly, the catheter 200 may be firmly fixed by being inserted into the through hole 111 by a predetermined length.
  • the endoscope cap 110 has a through hole 111 formed therein, so that the catheter 200 can be inserted.
  • the laser treatment device according to the present invention can be formed in a modularized structure. For example, the operator can select whether to use the body 100 in combination with the catheter 200 according to the purpose of the procedure.
  • the endoscope cap 110 may have an outer surface formed in a curved surface, for example, may be formed in a schematic cylindrical shape. Therefore, when inserted into a patient's body, there is no angularly protruding portion, thereby reducing the risk of damaging the mucous membrane of the patient's organs, such as the mucous membrane of the duodenum.
  • the first LED 112 may be radially disposed along the surface of the endoscope cap 110 as will be described later, and a large area of the lower mucosa of the duodenum may be irradiated with the first light L1.
  • a light source for example, a surface light source using an OLED, may be disposed in the curved hood 120 as will be described later in consideration of the curved structure and the curvature of the duodenum and mucosal folds.
  • the endoscope cap 110 may be formed of a transparent material.
  • the endoscope cap 110 may be a transparent cap.
  • the hood 120 may be configured to be disposed on an outer region of the endoscope cap 110 .
  • the hood 120 may be coupled to the outside of the endoscope cap 110 , and at least one region may be formed to protrude forward than the endoscope cap 110 .
  • the hood 120 may be disposed on the upper side of the endoscope cap 110 with reference to FIG. 3 . Therefore, as will be described later, after the main body 100 is inserted into the duodenum of the patient, the second LED 121 disposed in the hood 120 is disposed on the upper side of the duodenum, for example, the upper mucosa of the duodenum and the pancreas (the pancreas). ) may be irradiated toward the second light L2.
  • the first LED 112 may be disposed on the lower side of the endoscope cap 110 . Accordingly, after the main body 100 is inserted into the duodenum of the patient, the first LED 112 disposed on the endoscope cap 110 is directed downward from the inside of the duodenum, for example, the first light L1 toward the lower mucosa of the duodenum. ) can be investigated.
  • the hood 120 may be formed as a curved surface having a curvature.
  • the hood may be formed in the shape of a plate-shaped wing formed to protrude toward the upper surface. Accordingly, the overall shape of the body 100 may be formed in a rough columnar shape in a state in which the hood 120 is coupled to the endoscope cap 110 . Accordingly, even when the main body 100 enters the inside of the patient's body, the risk of damaging the mucous membrane of the duodenum or other organs may be reduced.
  • the hood 120 may be formed in a joint structure.
  • the hood 120 may include at least one or more joints. Since the hood 120 may have flexibility including at least one joint, damage to the surrounding mucosa can be minimized when inserted into the duodenum of the patient.
  • the hood 120 includes a plurality of joints, but may have flexibility in both the longitudinal direction and the vertical direction thereof. That is, the hood 120 may be bent to be bent in the longitudinal direction or may be bent to be bent in the width direction.
  • the hood 120 may be formed in a joint structure so that at least one region may be lifted in a direction in which the ear is located, for example, may be bent and lifted to be bent in a longitudinal direction.
  • the hood 120 may be formed to a length of 4 to 6 cm in order to be easily inserted into the duodenum of a patient to perform treatment.
  • the length of the hood 120 is formed to be less than 4 cm, the second LED 121 is not sufficiently disposed on the surface of the hood 120 , so that the irradiation range of the second light L2 may be reduced.
  • the length of the hood 120 is formed to be longer than 6 cm, it may be difficult to easily enter the duodenum of the patient, and there is a problem in that the risk of damaging the surrounding mucosa during entry increases.
  • Figure 4 (a) is a view of the main body 100 of Figure 2 viewed from below
  • Figure 4 (b) is a view of the main body 100 of Figure 2 viewed from above
  • Figure 5 is to explain the light emitted by the LEDs is a drawing for
  • At least one first LED 112 may be disposed on the endoscope cap 110 .
  • at least one first LED 112 may be disposed on the lower surface of the endoscope cap 110 .
  • the first LED 112 may be a means for irradiating the first light L1 of the first wavelength band.
  • the first LED 112 may be a point light source to be optimized to the curved structure of the endoscope cap 110, specifically, the first LED 112 may be a mini LED, micro LED, OLED. Therefore, the endoscope cap 110 including the first LED 112 can be miniaturized, and an appropriate procedure can be performed inside the patient's body.
  • the first LED 112 is a quantum dot ( It may be a quantum dot LED using quantum dot) as a light source.
  • the frequency and wavelength of the first light L1 irradiated through the first LED 112 can be efficiently controlled, and power consumption can be reduced. That is, when the first LED 112 is a quantum dot LED, light wavelength conversion may be relatively free.
  • a plurality of first LEDs 112 may be disposed on the surface of the endoscope cap 110 .
  • the first LED 112 is radially disposed on the surface of the endoscope cap 110, it may be disposed to form a plurality of columns and rows.
  • the first light L1 irradiated from the first LED 112 is not irradiated in a straight line from the endoscope cap 110, but is irradiated radially to widen the lower mucosa of the duodenum. area can be irradiated.
  • the first LED 112 may be a flexible LED, for example, a flexible OLED. That is, the first LED 112 may be one in which a surface light source using an OLED is disposed on the surface of the endoscope cap 110 . Therefore, it can be easy to arrange the first LED 112 on the surface of the endoscope cap 110, and the first LED 112 can be arranged to form a curved surface to correspond to the shape of the surface of the endoscope cap 110, , it is possible to efficiently irradiate the first light L1 to the lower mucosa of the duodenum.
  • a flexible LED for example, a flexible OLED. That is, the first LED 112 may be one in which a surface light source using an OLED is disposed on the surface of the endoscope cap 110 . Therefore, it can be easy to arrange the first LED 112 on the surface of the endoscope cap 110, and the first LED 112 can be arranged to form a curved surface to correspond to the shape of the surface of the endoscope cap 110
  • the first LED 112 may be a quantum dot LED and a flexible OLED arranged independently for each wavelength.
  • a quantum dot LED and a flexible OLED for each wavelength may be independently disposed on the surface of the endoscope cap 110 . Accordingly, the first LED 112 may irradiate light of a desired wavelength to a desired portion of the duodenum, thereby improving treatment efficiency.
  • the first LED 112 may be arranged in a hybrid form in which a quantum dot LED and a flexible OLED are mixed. Accordingly, the first LED 112 may efficiently irradiate the first light L1 to the lower mucosa of the duodenum, and may improve treatment efficiency.
  • At least one second LED 121 may be disposed on the hood 120 .
  • at least one second LED 121 may be disposed on the upper surface of the hood 120 .
  • the second LED 121 may be a means for irradiating the second light L2 in the second wavelength band.
  • the second LED 121 may be a point light source to be optimized for the curved structure of the hood 120 , and specifically, the second LED 121 may be a mini LED, a micro LED, or an OLED. Accordingly, the hood 120 including the second LED 121 may be miniaturized, and an appropriate procedure may be performed inside the patient's body.
  • the second LED 121 may be a quantum dot LED using a quantum dot as a light source. Accordingly, by adjusting only the size of the particles, the frequency and wavelength of the second light L2 irradiated through the second LED 121 can be efficiently controlled, and power consumption can be reduced. That is, when the second LED 121 is a quantum dot LED, light wavelength conversion may be relatively free.
  • a plurality of second LEDs 121 may be disposed on the surface of the hood 120 .
  • the second LED 121 is radially disposed on the surface of the hood 120 , and may be disposed to form a plurality of columns and rows.
  • the first light L2 irradiated from the second LED 121 is not irradiated in a straight line from the hood 120 , but is irradiated radially to a large area of the upper mucosa of the duodenum. It can be irradiated to, and further can be irradiated to the pancreas.
  • the second LED 121 may be a flexible LED, for example, a flexible OLED. That is, the second LED 121 may have a surface light source using an OLED disposed on the surface of the hood 120 . Therefore, it may be easy to arrange the second LED 121 on the surface of the hood 120 , and the second LED 121 may be arranged to form a curved surface so as to correspond to the shape of the surface of the hood 120 , the duodenum It is possible to efficiently irradiate the second light L2 to the upper mucous membrane of
  • the second LED 121 may be a quantum dot LED and a flexible OLED independently arranged for each wavelength.
  • the quantum dot LED and the flexible OLED for each wavelength may be independently disposed on the surface of the hood 120 . Accordingly, the second LED 121 may irradiate light of a desired wavelength to a desired portion of the duodenum, thereby improving treatment efficiency.
  • the second LED 121 may be arranged in a hybrid form in which a quantum dot LED and a flexible OLED are mixed. Accordingly, the second LED 121 may efficiently irradiate the second light L2 to the upper mucosa of the duodenum, and may improve treatment efficiency.
  • the first LED 112 disposed on the endoscope cap 110 may irradiate the first light L1
  • the second LED 121 disposed on the hood 120 may emit the second light (L2) can be investigated.
  • the first LED 112 and the second LED 121 may be arranged in schematically opposite directions to irradiate light toward the upper side and the lower side, respectively. Accordingly, light having different wavelength bands may be irradiated in different directions.
  • a first LED 112 irradiating a first light L1 of a first wavelength band may be disposed on the surface of the endoscope cap 110, and a second wavelength band different from the first wavelength band may be disposed on the surface of the hood 120.
  • a second LED 121 emitting 2 light L2 may be disposed.
  • the first light L1 and the second light L2 may be light irradiated for cell regeneration treatment of the duodenal mucosa or the pancreas.
  • the first wavelength band may be a predetermined wavelength range between 600 and 700 nm
  • the second wavelength band may be a predetermined wavelength range between 800 and 900 nm.
  • the first light L1 has a wavelength band of the first wavelength band and is irradiated toward the lower mucosa of the duodenum, and may have a relatively high surface temperature. Therefore, by irradiating the first light L1, not only the photodynamic treatment but also the efficient photothermal treatment effect can be expected at the same time.
  • the second light L2 has a wavelength band of the second wavelength band and is irradiated toward the upper mucosa of the duodenum, and has high transmittance compared to energy efficiency. Therefore, when the second light L2 is irradiated toward the upper mucosa of the duodenum, the second light L2 may reach the pancreas located on the upper side of the duodenum, so that cell regeneration treatment, that is, wound healing may be possible.
  • a distribution ratio of the first wavelength band and the second wavelength band may be 2:1 or 3:1.
  • a distribution ratio of the first light L1 and the second light L2 may be 2:1 or 3:1.
  • the present invention efficient treatment is possible by irradiating light having a plurality of wavelength bands in different directions through a single device.
  • the first light (L1) is irradiated toward the lower mucosa of the duodenum
  • the second light (L2) is irradiated toward the upper mucosa of the duodenum, so it helps the duodenum and pancreas cells regenerate and secretes diabetes-related hormones such as GIP It can inhibit the cellular function of cells involved in In other words, it is possible to improve the mitochondrial function of normal cells by irradiating light through LEDs on the duodenal surface, inhibit the function of K cells by increasing ATP production, and trigger regeneration of normal duodenal and pancreatic cells.
  • treatment of type 2 diabetes and metabolic diseases can be performed by improving the function of normal flora in the small intestine and inhibiting the proliferation of abnormal flora related to diabetes and metabolic diseases through efficient photo microbiota transplant (PMT). .
  • PMT photo microbiota transplant
  • FIG. 6 is a view for explaining an example of use of the low-level laser treatment device 10 using the LED endoscope cap according to the present invention.
  • the main body 100 may be inserted into the duodenum to irradiate light to the upper mucous membrane of the duodenum, the pancreas (pancreas), and the lower mucosa of the duodenum.
  • the air supply unit may reduce the air supply amount. For example, when the hood 120 comes into contact with a desired portion, the operator may reduce the amount of air insufflation through the air supply unit. At this time, as the amount of air is reduced, the lumen of the duodenum may contract, whereby the upper mucosa of the duodenum may be in contact with the hood 120 over a larger area.
  • the hood 120 since the hood 120 is formed in a joint structure and has flexibility, the hood 120 may be in contact with the upper mucosa of the duodenum in a wider area when the amount of air is reduced.
  • the hood 120 is configured as a transparent cap structure, so that the degree of adhesion to the duodenal mucosa can be detected in real time.
  • FIG. 7 is an enlarged view of X of FIG. 3 .
  • the hood 120 may include a curved region 122 formed in a curved surface at one end.
  • the body 100 is connected to the catheter 200 and inserted into the body of the patient. Accordingly, as the main body 100 is inserted through the inside of the body, a problem of damaging the mucous membrane of the organ or the surface of the organ may occur. Accordingly, in order to minimize such damage, the components constituting the body 100 may have curved surfaces.
  • the bent region 122 may be formed at one end of the hood 120 , and for example, the bent region 122 may be formed at the frontmost end of the hood 120 .
  • the curved region 122 is located at the frontmost end of the hood 120 , and is smoothly formed in a curved surface so that it can slide naturally when it comes into contact with the mucous membrane of the duodenum or other intestines.
  • the front end of the hood 120 located at the fore end of the main body 100 comes into contact with the surrounding mucosa first and a lot. Since the curved region 122 is formed at the front end, damage to the mucous membrane can be minimized.
  • FIG. 8 is a side view of the low-level laser treatment device 10 using the LED endoscope cap of FIG. 2 .
  • the hood 120 may be disposed on one area outside the endoscope cap 110 , and at least one area may be disposed to protrude forward than the endoscope cap 110 .
  • the front refers to the longitudinal direction of the hood 120 , and refers to the opposite direction of the portion to which the catheter 200 is connected, and refers to the right side with reference to FIG. 8 .
  • the hood 120 and the endoscope cap 110 may have a relatively different position, for example, at least one region of the hood 120 may be disposed to protrude forward than the endoscope cap 110 .
  • the second LED 121 disposed on the hood 120 may be disposed at a relatively deeper position in the duodenum than the first LED 112 disposed on the endoscope cap 110 . Accordingly, the second LED 121 may irradiate the second light L2 to the upper mucosa of the duodenum and a large area of the pancreas, and the first LED 112 may emit the first light L1 to the lower mucosa of the duodenum. It can be irradiated over a large area.
  • FIG. 9 is a view showing an embodiment of the hood 120 of FIG. 3
  • FIG. 10 is a view showing another embodiment of the hood 120 of FIG. 3 .
  • the angle of the hood 120 is changed in order for the hood 120 to contact the upper mucosa with the largest possible area.
  • the LED disposed on the hood 120 is a large area of the upper mucosa and The LEDs placed on the endoscopic cap 110 may still be directed towards the lower mucosa of the duodenum.
  • At least one area of the hood 120 may be movable to form a predetermined angle from the endoscope cap 110 .
  • the hood 120 may be rotatable in a state in which one side is coupled to the endoscope cap 110 and fixed.
  • the hood 120 may be hinged with the endoscope cap 110 .
  • the hinged portion may be a rotation axis of the hood 120 .
  • the rotation angle A1 of the hood 120 may be 5 to 15°.
  • the rotation angle of the hood 120 is 5° or less, a problem may occur that the LED disposed on the hood 120 does not contact the upper mucosa over an appropriate area.
  • the rotation angle of the hood 120 is 15° or more, a problem in that the contact area between the upper mucous membrane and the hood 120 is reduced may occur.
  • a portion of the front portion of the hood 120 may be bent.
  • a portion of the hood 120 coupled to the endoscope cap 110 may be maintained without bending, and the other side thereof may be bent in a direction toward the upper mucosa.
  • the angle at which the front of the hood 120 is bent may be 5 to 15°.
  • the front portion of the hood 120 is bent by 5° or less, there may be a problem that the LED disposed on the hood 120 does not contact the upper mucosa over an appropriate area.
  • the angle at which the front of the hood 120 is bent is 15° or more, a problem in that the area in which the upper mucous membrane and the hood 120 are in contact is reduced may occur.
  • FIG. 11 is a view for explaining the interior of the main body 100 .
  • the laser treatment device may further include a band 130 .
  • a band 130 having a smaller diameter than the diameter of the through hole 111 may be inserted into the through hole 111 .
  • the tube used for the endoscope since the tube used for the endoscope has various specifications, it is preferable that various tubes are inserted and fixed as necessary. Therefore, when the catheter 200 having a smaller diameter than the diameter of the through hole 111 is inserted, the inside of the through hole 111 has a smaller diameter than the diameter of the through hole 111 so that the catheter 200 is firmly fixed.
  • a band 130 may be inserted. That is, by inserting the band 130 inside the through hole 111, the laser treatment device 10 according to the present embodiment can be compatible with endoscopes of various diameters.
  • the catheter 200 may be easily inserted, and the band 130 may be formed of a soft material in order to firmly fix the inserted catheter 200 .
  • the band 130 may be formed of a silicon material.
  • the band 130 may be formed in a ring shape.
  • it may be formed in a ring shape in which a circular hole is formed.
  • the present invention is not limited thereto, and any structure capable of easily fixing the catheter 200 inserted into the through hole 111 may be employed.
  • the band 130 may be detachably inserted into the through hole 111 formed in the endoscope cap 110 .
  • the operator may insert the band 130 into the through hole 111 so that the catheter 200 is firmly inserted or fixed.
  • the catheter 200 is directly inserted into the through hole 111 in a state where the band 130 is not inserted into the through hole 111 and can be used. have.
  • connections or connecting members of the lines between the components shown in the drawings exemplify functional connections and/or physical or circuit connections, and in an actual device, various functional connections, physical connections that are replaceable or additional may be referred to as connections, or circuit connections.
  • connections or circuit connections.
  • a low-level laser treatment device using an LED endoscope cap there is provided a low-level laser treatment device using an LED endoscope cap.
  • the embodiment of the present invention can be applied to a low-level laser treatment device used in industry.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
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  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endoscopes (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un dispositif de thérapie laser de faible niveau utilisant un capuchon d'endoscope à LED. Un aspect de la présente invention peut comprendre : un cathéter formé pour s'étendre et être inséré dans un corps d'un patient et comprenant une partie de transmission d'air ; un capuchon d'endoscope ayant un trou traversant qui s'étend à travers l'intérieur de celui-ci pour permettre l'insertion du cathéter dans celui-ci ; un capot qui est disposé dans une zone d'un côté extérieur du capuchon d'endoscope et dans lequel au moins une zone du capot est disposée de façon à faire saillie plus vers l'avant que le capuchon d'endoscope ; et au moins une LED disposée sur chacun du capuchon d'endoscope et du capot.
PCT/KR2022/004465 2021-04-22 2022-03-29 Dispositif de thérapie laser de faible niveau utilisant un capuchon d'endoscope à led WO2022225218A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP22791918.0A EP4327863A4 (fr) 2021-04-22 2022-03-29 Dispositif de thérapie laser de faible niveau utilisant un capuchon d'endoscope à led
US18/556,360 US20240342504A1 (en) 2021-04-22 2022-03-29 Low-level laser therapy device using led endoscope cap
JP2023564138A JP2024515102A (ja) 2021-04-22 2022-03-29 Ｌｅｄ内視鏡キャップを用いた低レベルレーザー治療器

Applications Claiming Priority (2)

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KR10-2021-0052572 2021-04-22
KR1020210052572A KR102567070B1 (ko) 2021-04-22 2021-04-22 Led 내시경 캡을 이용한 저준위 레이저 치료기

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WO2022225218A1 true WO2022225218A1 (fr) 2022-10-27

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US (1) US20240342504A1 (fr)
EP (1) EP4327863A4 (fr)
JP (1) JP2024515102A (fr)
KR (2) KR102567070B1 (fr)
WO (1) WO2022225218A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012239833A (ja) * 2011-05-24 2012-12-10 Olympus Medical Systems Corp 内視鏡用フード
JP2013031541A (ja) * 2011-08-02 2013-02-14 Fujifilm Corp 内視鏡装置
WO2016047191A1 (fr) * 2014-09-25 2016-03-31 オリンパス株式会社 Systeme d'endoscope
KR101971185B1 (ko) * 2018-05-24 2019-04-23 부경대학교 산학협력단 광 조사 장치
JP2019150388A (ja) * 2018-03-05 2019-09-12 五稜化薬株式会社 内視鏡用アプリケータ装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101670401B1 (ko) * 2015-02-26 2016-10-28 가톨릭대학교 산학협력단 광역동 치료 캡 및 이를 결합한 내시경

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012239833A (ja) * 2011-05-24 2012-12-10 Olympus Medical Systems Corp 内視鏡用フード
JP2013031541A (ja) * 2011-08-02 2013-02-14 Fujifilm Corp 内視鏡装置
WO2016047191A1 (fr) * 2014-09-25 2016-03-31 オリンパス株式会社 Systeme d'endoscope
JP2019150388A (ja) * 2018-03-05 2019-09-12 五稜化薬株式会社 内視鏡用アプリケータ装置
KR101971185B1 (ko) * 2018-05-24 2019-04-23 부경대학교 산학협력단 광 조사 장치

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP4327863A4 *

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EP4327863A1 (fr) 2024-02-28
KR102567070B9 (ko) 2024-03-13
KR20220145685A (ko) 2022-10-31
KR102567070B1 (ko) 2023-08-16
KR20230136085A (ko) 2023-09-26
US20240342504A1 (en) 2024-10-17
EP4327863A4 (fr) 2024-09-25
JP2024515102A (ja) 2024-04-04
KR102644509B1 (ko) 2024-03-08

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