WO2022223421A1 - Utilisation de mg2+, de vitamine c et de coenzyme q10 dans la formation de seuil de lactate - Google Patents

Utilisation de mg2+, de vitamine c et de coenzyme q10 dans la formation de seuil de lactate Download PDF

Info

Publication number
WO2022223421A1
WO2022223421A1 PCT/EP2022/059989 EP2022059989W WO2022223421A1 WO 2022223421 A1 WO2022223421 A1 WO 2022223421A1 EP 2022059989 W EP2022059989 W EP 2022059989W WO 2022223421 A1 WO2022223421 A1 WO 2022223421A1
Authority
WO
WIPO (PCT)
Prior art keywords
athlete
lactate
coenzyme
vitamin
saliva
Prior art date
Application number
PCT/EP2022/059989
Other languages
English (en)
Inventor
Andrea BULBARELLO
Jonas WITTWER SCHEGG
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of WO2022223421A1 publication Critical patent/WO2022223421A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B19/00—Teaching not covered by other main groups of this subclass
    • G09B19/0092—Nutrition
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/60—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets

Definitions

  • the present invention relates to nutrition for athletic performance. It also relates to lactate threshold (LT) training and other methods of improving high-intensity endurance performance.
  • LT lactate threshold
  • BLC Blood lactate concentration
  • EP 2898826 B1 discloses a lactate measuring device comprising a transdermal microneedles sensor. It has also been found that salivary lactate concentrations correspond well with blood lactate levels (Jayoung et al., "Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites", Analyst, 2014, 139, 1632). This corresponds to the findings of Tekus et al. (Tekus, Eva et al., Acta Biologica Hungarica, March 2012, Supplement 1, Vol. 63, p89-98, 10p). A device for measuring lactate in saliva is commercially available at TRAQ ® (Carlsbad, CA, USA). Thus, direct access to the athlete's blood is no longer required.
  • Lactate threshold training aims to increase the anaerobic threshold intensity of an athlete. Beneke et al. found that MLSS decreases with increasing mass ofthe primarily engaged muscles (Beneke etal., "Dependence ofthe maximal lactate steady state on the motor pattern of exercise", Br J Sports Med 2001; 35:192-196). Increasingthe anaerobic threshold by physical exercise requires suitable nutrition. Indeed, nutrition can markedly influence physical performance.
  • Patlar et al. found that the increase in lactate level due to a 4-week exhaustion exercise are offset by vitamin C supplementation (Patlar et al. "Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise", Annals of Applied Sport Science 2017, vol. 5, no. 2, pp. 21-27).
  • Dietary supplements comprising Mg 2+ , vitamin C and/or coenzyme Q10 are available at DSM ® Nutritional Products (Switzerland).
  • DSM ® Nutritional Products (Switzerland).
  • athletes have a hard time to find out if the oral intake of a dietary supplement has paid off.
  • the method should be easy such that an athlete can apply it himself.
  • a product that supports an athlete ' s lactate threshold training there is a need for a product that supports an athlete ' s lactate threshold training.
  • kits for assessing the effect of dietary supplementation on exercise-induced lactate in saliva, wherein said detection system is suitable for determining the level of lactate in saliva.
  • a kit is provided.
  • the kit of the present invention preferably comprises:
  • the kit ' s dietary supplement comprises Mg 2+ , vitamin C and coenzyme Q10.
  • the athlete When assessing the effect of dietary supplementation on exercise-induced lactate in saliva, the athlete is supported by the computer-implemented method of the present invention.
  • it is a computer-implemented method of providing a recommendation to an athlete, said method comprising the steps: a) receiving data, said data comprising:
  • step b) estimating the athlete ' s average oral intake of Mg 2+ , vitamin C and coenzyme Q10 using the data provided in step a), and optionally estimating the athlete ' s anaerobic threshold intensity using the data provided in step a) c) providing a model which defines average oral intakes of Mg 2+ , vitamin C and coenzyme Q10 that are prerequisites for increasing the anaerobic threshold intensity by lactate threshold training d) using the model of step c) to determine if the athlete needs to increase his average oral intake of Mg 2+ , vitamin C and/or coenzyme Q10 e) providing at least one recommendation to the athlete, wherein said recommendation relates (directly or indirectly) to the athlete ' s anaerobic threshold intensity
  • a preferred detection system for determining the level of lactate in saliva comprises at least three components being a reader device, a cartridge and a collection tip, wherein said reader device preferably comprises:
  • the present invention relates to a kit, to the use of a detection system for determining the level of lactate in saliva and to a computer-implemented method of providing a recommendation to an athlete.
  • the present invention relates to the use of a detection system for determining the level of lactate in saliva.
  • the detection system is part of the kit of the invention, is an element of the claimed use and can be used to deliver data that may be needed in the computer-implemented method of the invention.
  • a typical detection system comprises one or more components.
  • a preferred detection system comprises a reader device, a cartridge and/or a collection tip.
  • Preferred cartridges are single use cartridges that can be inserted into the reader device. Therefore, a preferred reader device has at least one cavity configured to receive cartridges that are preferably single use cartridges.
  • the preferred collection tip is a single use collection tip can be inserted into the cartridge. Therefore, a preferred cartridge is a single use cartridge that has at least one cavity configured to receive a single use collection tip.
  • the preferred collection tip is placed on the tongue to collect saliva. Once saturated, the collection tip can then be inserted into the cartridge.
  • the single use cartridge can be disposed of together with the single use collection tip.
  • the reader device of the described detection system sends the determined level of lactate within seconds to minutes to a computer, preferably to a smartphone (or any other handheld electronic device).
  • the reader device comprises at least one cavity configured to receive cartridges, a memory storing at least computer-readable instructions, a processor in communication with said memory, and/or a communication interface. Dietary supplement
  • a dietary supplement is intended to supplement one's diet.
  • a dietary supplement is preferably intended to supplement an athlete's diet such that the athlete's lactate threshold training is more successful or is successful at all.
  • athlete isto be understood in a broad manner.
  • an athlete is anyone doing sports once, occasionally or regularly. More preferably, an athlete is anyone seekingto improve his high-intensity endurance performance.
  • lactate threshold is the point at which lactate begins to accumulate in the body. It is usually reached between 50% to 80% of an athlete's V02 max.
  • the “anaerobic lactate threshold intensity” is the highest sustained intensity of exercise for which oxygen uptake can account for the entire energy requirement.
  • lactate threshold and “anaerobic lactate threshold intensity” may be used synonymously.
  • lactate threshold training is to be understood in a broad manner. Preferably, lactate threshold training is any activity aiming for improving endurance performance. More preferably, lactate threshold training is any physical activity aiming for increasing the anaerobic threshold intensity.
  • a dietary supplement comprises preferably at least one blood lactate reducer.
  • Mg 2+ , vitamin C and/or coenzyme Q10 are preferred examples of blood lactate reducer. Because salivary lactate levels correlate with blood lactate levels, blood lactate reducer are also saliva lactate reducers and vice versa.
  • a dietary supplement comprises preferably Mg 2+ , vitamin C, coenzyme Q10 or a combination thereof.
  • the herein described dietary supplement is preferably intended to supplement an athlete's diet with Mg 2+ , vitamin C, coenzyme Q10 and/or any other blood lactate reducer.
  • Dietary supplementation is supplementation of one’s diet with a dietary supplement.
  • a dietary supplement is preferably an oral dietary supplement (i.e. for oral intake). Therefore, in the context of the present invention, dietary supplementation is preferably supplementation of one’s diet with an oral dietary supplement.
  • Preferred oral dietary supplement formats are gels, capsules, tablets, pills, powders, drinks and edible gummies (e.g. fortified gummy bears). Thereby, the term “gel” is to be understood in a broad manner and includes fortified fruit purees. Gels are typically packed in pouches or alike.
  • a dietary supplement is preferably an oral dietary supplement that comprises preferably at least one blood lactate reducer being preferably Mg 2+ , vitamin C and/or coenzyme Q10.
  • dietary supplementation is preferably supplementation of an athlete's diet with oral dietary supplement that comprises preferably at least one blood lactate reducer being preferably Mg 2+ , vitamin C and/or coenzyme Q10.
  • kits are a set of articles or equipment needed for a specific purpose.
  • the preferred purpose of the kit of the present invention is supporting athletes in their wish to increase their anaerobic threshold intensity.
  • the kit of the present invention comprises at least one dietary supplement and at least one component of a detection system for determining the level of lactate in saliva.
  • said dietary supplement comprises at least one blood lactate reducer, and wherein said at least one blood lactate reducer is preferably Mg 2+ , vitamin C, coenzyme Q10 or a combination thereof, and wherein said dietary supplement comprises preferably Mg 2+ , vitamin C and coenzyme Q10, and/or wherein said at least one dietary supplement is a gel, a capsule, a tablet, a pill, a powder, a drink or an edible gummy, and wherein said at least one dietary supplement is preferably a gel, and/or wherein said at least one component of said detection system is a reader device, a cartridge and/or a collection tip, and wherein said reader device preferably comprises:
  • the detection system for determining the level of lactate in saliva comprises at least one single use component (e.g. a single use cartridge and/or a single use collection tip).
  • the athlete receives a supply of single use components regularly by mail.
  • the kit of the invention may be a parcel or an envelope that is sent to the athlete or any other recipient (e.g. every month or every second month on the basis of a subscription).
  • the kit of the present invention comprises preferably at least one dietary supplement, at least one single use cartridge and/or at least one single use collection tip.
  • the reader device is reusable and thus needs to be sent to the athlete once only.
  • kits of the invention comprises one kind dietary supplement only, wherein said dietary supplement comprises Mg 2+ , vitamin C and coenzyme Q10.
  • a preferred embodiment of the present invention relates to a kit comprising:
  • each of said multiple oral dietary supplements comprises Mg 2+ , vitamin C and coenzyme Q10, and wherein said components of said detection system are single use components and are preferably single use cartridges and/or single use collection tips, and wherein said kit is optionally a parcel or an envelope, and wherein dietary supplements are preferably pouches comprising a gel.
  • the kit of the invention may comprise three kinds of dietary supplements, wherein a first kind comprises Mg 2+ , a second kind comprises vitamin C and a third kind comprises coenzyme Q10.
  • a kit comprising:
  • the computer-implemented method of the invention allows to assess if supplementation of an athlete's diet with the herein described dietary supplement has paid off.
  • at least one level of lactate (that has been determined ex vivo in the saliva of the athlete after physical exercise) is among the input of the method.
  • the herein describe detection system has preferably been used to determine the level(s) of lactate in saliva.
  • the use of the herein describe detection system for assessing the effect of dietary supplementation on exercise-induced lactate in saliva is novel and surprising.
  • One embodiment of the present invention relates to the use of a detection system for assessing the effect of dietary supplementation on exercise-induced lactate in saliva, wherein said detection system is suitable for determining the level of lactate in saliva.
  • a preferred embodiment of the present invention relates to the use of a detection system for assessing the effect of supplementation of an athlete's diet with at least one blood lactate reducer on exercise-induced lactate in saliva, wherein said detection system is suitable for determining the level of lactate in saliva, and wherein said at least one blood lactate reducer is preferably Mg 2+ , vitamin C, coenzyme Q10 or a combination thereof.
  • Assessingthe effect of dietary supplementation on exercise-induced lactate in saliva is particularly meaningful if measured ex vivo in saliva that has been collected preferably not more than 4 minutes, more preferably not more than 3 minutes, even more preferably not more than 2 minutes and most preferably not more than 1 minute after physical exercise (e.g. after maximum intensity exercise).
  • salivary lactate concentration is highest when an athlete reaches his limit and then decreases as the athlete is recovering.
  • a preferred embodiment of the present invention relates to the use of the herein described detection system for assessing the effect of the herein described dietary supplementation on exercise-induced lactate in saliva, wherein said detection system is used for determining the level of lactate in saliva that has been collected preferably not more than 4 minutes, more preferably not more than 3 minutes, even more preferably not more than 2 minutes and most preferably not more than 1 minute after physical exercise, and wherein the effect of a dietary supplement comprising at least one blood lactate reducer on exercise-induced lactate in saliva is assessed, and wherein said blood lactate reducer is preferably Mg 2+ , vitamin C, coenzyme Q10 or a combination thereof.
  • the level of lactate in saliva may be determined after multiple or each period of a graded exercise test.
  • the athlete may perform a maximal Astrand treadmill test [Astrand, P. 0., Ryhming, I. (1954) A nomogram for calculation of aerobic capacity (physical fitness) from pulse rates during submaximal work. J. Appl. Physiol. 7, 218-222] meanwhile heart rate (HR) data is optionally also registered (e.g. by the athlete's watch).
  • HR heart rate
  • the speed of a treadmill e.g. Trackmaster TMX-425, Full Vision Inc., Newton, USA
  • a preferred embodiment of the present invention relates to computer-implemented method of providing a recommendation to an athlete, said method comprising the steps: a) receiving data, said data comprising:
  • step a) estimating the athlete ' s average oral intake of Mg 2+ , vitamin C and coenzyme Q10 using the data provided in step a), and optionally estimating the athlete ' s anaerobic threshold intensity using the data provided in step a) c) providing a model which defines average oral intakes of Mg 2+ , vitamin C and coenzyme Q10 that are prerequisites for increasing the anaerobic threshold intensity by lactate threshold training d) using the estimation of step b) and the model of step c) to determine if the athlete needs to increase his average oral intake of Mg 2+ , vitamin C and/or coenzyme Q10 e) providing at least one recommendation to the athlete, wherein said recommendation relates directly or indirectly to the athlete ' s anaerobic threshold intensity, and wherein the food diary received in step a) also comprises information about the athlete ' s oral intake of dietary supplements, and/or wherein at least three
  • a computer-implemented invention involves the use of a computer, computer network or other programmable apparatus.
  • data is preferably received by a computer program that is run on a computer, computer network or other programmable apparatus.
  • said data is received by a computer application that is run on the smartphone (or any other handheld electronic device) of the athlete.
  • step a) may be sent by a computer program that is run on a computer, computer network or other programmable apparatus.
  • the reader device of the herein described detection system for determining the level of lactate in saliva sends test results to above described computer application that is run on the smartphone of the athlete.
  • said computer application is also capable of receiving heart rate data of the athlete (e.g. heart rate data that is sent from the athlete's watch). If heart rate data of the athlete is received in step a), the athlete ' s anaerobic threshold intensity may be more reliably estimated in step b).
  • a food diary of the athlete is also received.
  • Said diary is about the athlete's food habits and may or may not be received by the above described computer application.
  • Any kind of food diary is acceptable as long as it allows to estimate the athlete ' s average oral intake of Mg 2+ , vitamin C and coenzyme Q10.
  • "average oral intake” is to be understood in broad manner.
  • it is possible to calculate an average from two data points only it is preferred to have significantly more than two data points. The more data points are available, the better is the estimate of step b) of the computer-implemented method of the present invention.
  • step a) of the computer implemented method of the present invention further data is optionally received such as age, sex, height and/or body weight of the athlete. If such data is received, the model provided in step c) may take into account that the optimal oral intakes of Mg 2+ , vitamin C and coenzyme Q10 slightly depends on the age, sex, height and/or body weight of the athlete.
  • the model provided in step c) defines average oral intakes of Mg 2+ , vitamin C and coenzyme Q10 that are prerequisites for increasing the anaerobic threshold intensity by lactate threshold training.
  • This model is then used in step d) to determine if the athlete needs to increase his average oral intake of Mg 2+ , vitamin C and/or coenzyme Q10.
  • the model of step c) is part of a computer program that is run on a computer, computer network or other programmable apparatus.
  • the model of step c) is part ofthe computer application that is run on the smartphone ofthe athlete.
  • step e) ofthe computer implemented method ofthe present invention at least one recommendation is provided to the athlete.
  • said recommendation is the output of a computer program that is run on a computer, computer network or other programmable apparatus. More preferably, said recommendation is the output of the computer application that is run on the smartphone of the athlete.
  • the recommendation of provided in step e) relates directly or indirectly to the athlete ' s anaerobic threshold intensity.
  • the expression "directly or indirectly” can also mean that a simple information is provided in step e).
  • the athlete ' s estimate anaerobic threshold intensity may be provided in step e).
  • the recommended oral intakes of Mg 2+ , vitamin C and coenzyme Q10 may be provided in step e). If data about the athlete's age, sex, height and/or body weight is available, the recommended oral intakes of Mg 2+ , vitamin C and coenzyme Q10 may be adapted to the specific needs of the athlete.
  • step d) has revealed that the athlete needs to increase his average oral intake of Mg 2+ , vitamin C and/or coenzyme Q10
  • the recommendation to increase the average oral intake of Mg 2+ , vitamin C and/or coenzyme Q10 is preferably provided in step e) of the computer implemented method of the present invention.
  • Said recommendation can be more specific by also suggesting at least one meal and/or at least one meal plan. Thereby, it is preferred to suggest meals that are rich in Mg 2+ , vitamin C and/or coenzyme Q10.
  • the oral intake of the herein described dietary supplement is recommended in step e).
  • Example 1 relates to an athlete that is training for a half marathon.
  • the athlete has the following characteristics:
  • the athlete would like to get the right micronutrients supplementation in order to enhance his running performances by decreasing the rate at which lactate is generated while working out (running/jogging) for reaching a better overall performance, decreasing fatigue and muscle recovery.
  • the athlete orders the kit of the invention.
  • Said kit comprises a detection system for determining the level of lactate in saliva.
  • the athlete downloads a dedicated app on his smartphone.
  • the app is in communication with the kit ' s detection system.
  • the app also has a food logging function. Food logging is regularly requested by the app.
  • the output of the app ' s food logging function is a food diary that also comprises information about the athlete ' s oral intake of dietary supplements (if any).
  • the athlete then performs a graded exercise test on a stationary bike.
  • the exercise intensity is increased in periods of about 3 minutes and saliva samples are taken at the end of each period. Saliva is collected not more than 1 minute after each period.
  • Collection tips are a component of the kit's detection system. After each period on the stationary bike, the athlete places a single use collection tip on his tongue (like enjoying a lollipop). Once saturated, the respective collection tip is inserted into a single use cartridge that is placed in the cavity of the reader device. Reader device and cartridge are components of the kit's detection system.
  • the test result i.e. the level of lactate in saliva sample, measured ex vivo
  • the test result i.e. the level of lactate in saliva sample, measured ex vivo
  • the test result i.e. the level of lactate in saliva sample, measured ex vivo
  • Information may be shared via a dedicated cloud system.
  • the athlete ' s watch collects heart rate data of the athlete. This heart rate data is also sent to the to the app on the athlete ' s smartphone.
  • the app then provides the following information and recommendations to the athlete, all relating directly or indirectly to the athlete ' s anaerobic threshold intensity:
  • the app provides an estimated anaerobic threshold intensity to the athlete.
  • the estimate indicates that there is room for improvement, in particular in view of the envisaged half marathon.
  • the app informs the athlete that main micronutrients which affect exercise-induced lactate (i.e. lactate "production” during sport activities such as running/jogging) are Vitamin C, Mg 2+ and coenzyme Q10.
  • lactate "production" i.e. lactate "production" during sport activities such as running/jogging
  • the athlete learns that a sufficient intake of Mg 2+ , vitamin C and coenzyme Q10 is a prerequisite for increasing the anaerobic threshold intensity by lactate threshold training.
  • the app informs the athlete that, taking into consideration age, sex, height and body weight of the athlete, the Mg 2+ dosage should be in the range of 300 to 600 mg per day, the Vitamin C dosage should be in the range of 90 to 300 mg per day and the coenzyme Q10 dosage should be in the range of 150 mg to 300 mg per day.
  • the app reveals that, according to the athlete ' s food diary, the athlete ' s average oral intake of Mg 2+ , vitamin C and coenzyme Q10 is not sufficient. Therefore, the app recommends to the athlete to increase his oral intake of Mg 2+ , vitamin C and/or coenzyme Q10
  • Vitamin C 225 mg/day
  • Magnesium 420 mg/day
  • Coenzyme Q10 1 mg/day
  • the app also recommends the intake of fortified fruit puree containing Mg 2+ , vitamin Cand coenzyme Q10.
  • Three pouches of such fortified fruit puree are part of the kit the athlete has acquired.
  • the app allows the athlete to order a month supply (30 fortified fruit puree pouches) of such fortified fruit puree.
  • the pouches are then shipped to the athlete, together with single use components of the detection system (i.e. single use cartridges and single use collection tips).
  • the athlete of example 1 follows the recommendations of the app, keeps logging his food (including consumption of fortified fruit puree) and strictly follows an established lactate threshold training. The athlete then repeats the graded exercise test (including saliva sampling) of example 1. The app on the athlete's smartphone then provides the following information and recommendations to the athlete:
  • the app informs the athlete that according to the updated food diary, the athlete ' s average oral intake of Mg 2+ , vitamin C and coenzyme Q10 is now sufficient.
  • the athlete keeps following the recommendations of his app, keeps logging his food (including consumption of dietary supplement), follows the lactate threshold training and quietly observes how his anaerobic threshold intensity keeps improving. After 6 months in total, the athlete wins the half marathon in his age category.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Business, Economics & Management (AREA)
  • Educational Technology (AREA)
  • Physics & Mathematics (AREA)
  • Educational Administration (AREA)
  • Entrepreneurship & Innovation (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un complément alimentaire qui est approprié pour complémenter un régime d'athlète de telle sorte que l'apprentissage du seuil de lactate de l'athlète est plus réussi (ou est réussi). Le complément alimentaire comprend au moins un réducteur de lactate sanguin qui est de préférence Mg2+, de la vitamine C, de la coenzyme Q10 ou une combinaison de ceux-ci. Pour découvrir si l'ingestion orale d'un complément alimentaire a réussi, le kit de l'invention comprend, en plus du complément alimentaire, un système de détection (ou des composants de celui-ci) pour déterminer le taux de lactate dans la salive d'un athlète. La présente invention concerne également un procédé mis en œuvre par ordinateur pour fournir une recommandation à un athlète qui cherche à augmenter son intensité de seuil anaérobie par apprentissage optimisé de seuil de lactate.
PCT/EP2022/059989 2021-04-19 2022-04-14 Utilisation de mg2+, de vitamine c et de coenzyme q10 dans la formation de seuil de lactate WO2022223421A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21169045.8 2021-04-19
EP21169045 2021-04-19

Publications (1)

Publication Number Publication Date
WO2022223421A1 true WO2022223421A1 (fr) 2022-10-27

Family

ID=75581415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2022/059989 WO2022223421A1 (fr) 2021-04-19 2022-04-14 Utilisation de mg2+, de vitamine c et de coenzyme q10 dans la formation de seuil de lactate

Country Status (1)

Country Link
WO (1) WO2022223421A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236609A1 (en) * 2003-05-23 2004-11-25 Infinit Nutrition Holdings, Llc System and process for producing an individual formulation of physical enhancer
US20110300517A1 (en) * 2010-06-07 2011-12-08 Fieldberg J Harold Drug-free method and system for reduction of lactic acid while training athletes using ph balancing
US20130079599A1 (en) * 2011-09-25 2013-03-28 Theranos, Inc., a Delaware Corporation Systems and methods for diagnosis or treatment
US20150338387A1 (en) * 2012-12-21 2015-11-26 Joel R. L. Ehrenkranz Supplements and monitoring systems for dosing of the supplements
US20160328991A1 (en) * 2015-05-07 2016-11-10 Dexcom, Inc. System and method for educating users, including responding to patterns
US20180268726A1 (en) * 2012-10-09 2018-09-20 Kc Holdings I Personalized avatar responsive to user physical state and context
EP2898826B1 (fr) 2014-01-28 2019-01-30 Micro Nipple Technology Co., Ltd. Dispositif de mesure de lactate et procédé de réglage d'apprentissage en sport

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040236609A1 (en) * 2003-05-23 2004-11-25 Infinit Nutrition Holdings, Llc System and process for producing an individual formulation of physical enhancer
US20110300517A1 (en) * 2010-06-07 2011-12-08 Fieldberg J Harold Drug-free method and system for reduction of lactic acid while training athletes using ph balancing
US20130079599A1 (en) * 2011-09-25 2013-03-28 Theranos, Inc., a Delaware Corporation Systems and methods for diagnosis or treatment
US20180268726A1 (en) * 2012-10-09 2018-09-20 Kc Holdings I Personalized avatar responsive to user physical state and context
US20150338387A1 (en) * 2012-12-21 2015-11-26 Joel R. L. Ehrenkranz Supplements and monitoring systems for dosing of the supplements
EP2898826B1 (fr) 2014-01-28 2019-01-30 Micro Nipple Technology Co., Ltd. Dispositif de mesure de lactate et procédé de réglage d'apprentissage en sport
US20160328991A1 (en) * 2015-05-07 2016-11-10 Dexcom, Inc. System and method for educating users, including responding to patterns

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AGUILO ET AL.: "Antioxidant diet supplementation enhances aerobic performance in amateur sportsmen", J SPORTS SCI., vol. 25, no. 11, September 2007 (2007-09-01), pages 1203 - 10
ANONYMOUS: "New research collaboration for improved personal health tracking", 1 January 2020 (2020-01-01), XP055842850, Retrieved from the Internet <URL:www.dsm.com/human-nutrition/new-research-collaboration-for-improved-personal-health-tracking.html> [retrieved on 20210920] *
ARMANFAR ET AL.: "Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners", MJIRI, vol. 29, 2015, pages 202
ASTRAND, P. 0.RYHMING, I.: "A nomogram for calculation of aerobic capacity (physical fitness) from pulse rates during submaximal work", J. APPL. PHYSIOL., vol. 7, 1954, pages 218 - 222
BENEKE ET AL.: "Dependence of the maximal lactate steady state on the motor pattern of exercise", BR J SPORTS MED, vol. 35, 2001, pages 192 - 196
CHEN HSUAN-YING ET AL: "Magnesium Enhances Exercise Performance via Increasing Glucose Availability in the Blood, Muscle, and Brain during Exercise", vol. 9, no. 1, 20 January 2014 (2014-01-20), pages e85486, XP055842999, Retrieved from the Internet <URL:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0085486/1/pone.0085486.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa@plos-prod.iam.gserviceaccount.com/20210921/auto/storage/goog4_request&X-Goog-Date=20210921T065427Z&X-Goog-Expires=86400&X-Goog-SignedHeaders=h> [retrieved on 20210921], DOI: 10.1371/journal.pone.0085486 *
ÇLNAR ET AL.: "The effect of magnesium supplementation on lactate levels of sportsmen and sedanter", ACTA PHYSIOLOGICA HUNGARICA, vol. 93, no. 2-3, 2006, pages 137 - 144
JAYOUNG ET AL.: "Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites", ANALYST, vol. 139, 2014, pages 1632, XP055279412, DOI: 10.1039/c3an02359a
PALLESCHI G ET AL: "Determination of lactate in human saliva with an electrochemical enzyme probe", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 245, 1 January 1991 (1991-01-01), pages 151 - 157, XP026725369, ISSN: 0003-2670, [retrieved on 19910101], DOI: 10.1016/S0003-2670(00)80215-9 *
PATLAR ET AL.: "Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise", ANNALS OF APPLIED SPORT SCIENCE, vol. 5, no. 2, 2017, pages 21 - 27
TEKUS, EVA ET AL., ACTA BIOLOGICA HUNGARICA, vol. 63, March 2012 (2012-03-01), pages 89 - 98

Similar Documents

Publication Publication Date Title
Clark et al. Pre-and post-season dietary intake, body composition, and performance indices of NCAA division I female soccer players
Van Essen et al. Failure of protein to improve time trial performance when added to a sports drink
Gregory et al. A low-carbohydrate ketogenic diet combined with 6-weeks of crossfit training improves body composition and performance
US20110143322A1 (en) Method for weight management
Lehmkuhl et al. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures
Flores et al. Shorter sprints elicit greater cardiorespiratory and mechanical responses with less fatigue during time-matched sprint interval training (SIT) sessions
O’Keeffe et al. Dietary status of trained female cyclists
Ruud et al. Nutritional concerns of female athletes
JP2008204418A (ja) 生体情報管理システム
WO2022223421A1 (fr) Utilisation de mg2+, de vitamine c et de coenzyme q10 dans la formation de seuil de lactate
Woodruff Sports nutrition
Ahrens et al. The effects of caffeine in women during aerobic-dance bench stepping
Cakir-Atabek Effects of Acute Caffeine Ingestion on Anaerobic Cycling Performance in Recreationally Active Men.
US8764447B2 (en) Drug-free method and system for reduction of lactic acid while training athletes using ph balancing
Butterworth et al. The relationship between cardiorespiratory fitness, physical activity, and dietary quality
Coombes et al. Submaximal tests for cardiorespiratory fitness
Olsson Swedish Elite Swimmers Blood Glucose Levels During Recovery: A Descriptive Study Using Continuous Glucose Monitoring Systems
Dolins et al. Effect of variable carbohydrate intake on exercise performance in female endurance cyclists
Close et al. Nutrition for human performance
Boutcher Belly Fat Breakthrough
Astorino et al. Effects of Acute Caffeine Ingestion on Anaerobic Cycling Performance in Recreationally Active Men
Schweitzer et al. Timing carbohydrate beverage intake during prolonged moderate intensity exercise does not affect cycling performance
Greene et al. The best life guide to managing diabetes and pre-diabetes
Kouris-Blazos Nutrition for activity, sport and survival
Sumardilah et al. Determinants of body fitness in youth Wushu Athlete Saburai Lampung

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22723558

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 22723558

Country of ref document: EP

Kind code of ref document: A1