WO2022206148A1

WO2022206148A1 - Developing filament and occluder with developing function

Info

Publication number: WO2022206148A1
Application number: PCT/CN2022/073717
Authority: WO
Inventors: 王云兵; 郭高阳; 杨立
Original assignee: 四川大学
Priority date: 2021-03-29
Filing date: 2022-01-25
Publication date: 2022-10-06
Also published as: CN113081312B; CN113081312A; NL2031176A; NL2031176B1

Abstract

The present invention relates to a developing filament and an occluder with a developing function. The developing filament of the present invention comprises a filament main body and a first control end and a second control end disposed on the filament main body and used for taking in and releasing the filament main body, the first control end and the second control end respectively being positioned at two ends of the filament main body; the material of the developing filament is a polymer wire with a lubricating layer on the surface, the lubricating layer being loaded with a developing material; or the developing filament is a hydrogel wire loaded with a developing material. The developing filament of the present invention can be withdrawn outside the body after release of the occluder and can avoid the permanent residue of developing marks in the body whilst expanding the scope of development, facilitating the reduction of the difficulty and risk of surgery, and has a low elastic modulus and friction resistance, so that the end head of the developing filament will not cause damage to the tissue when being withdrawn.

Description

Development wire and occluder with development function

technical field

The invention relates to the field of medical instruments, in particular to a developing wire and an occluder with a developing function.

Background technique

Common congenital heart defects such as atrial septal defect (ASD), ventricular septal defect (VSD), patent ductus arteriosus (PDA), patent foramen ovale (PFO) and other heart defects, these congenital heart defects may cause cardiac function disorders and other cardiovascular and cerebrovascular complications. In addition, decreased atrial contraction in atrial fibrillation patients further reduces the blood flow velocity of the left atrial appendage, which is connected to the left atrium, causing blood to coagulate into a thrombus. If the thrombus falls off, it is likely to reach the intracranial blood vessels through the blood flow, blocking the small cerebral blood vessels, resulting in ischemic stroke. The occluder can be implanted at the site of total heart damage or the left atrial appendage by minimally invasive intervention. This method is the first choice for patients with congenital heart disease due to its mild trauma, safe operation, and accurate short-term and mid-term effects.

Most of the frame of the minimally invasive interventional occluder currently used clinically is a mesh structure, which is convenient to be compressed on the delivery device, so as to restore the shape of the diseased part and release it after delivery into the body, thereby completing the occlusion function. In order to achieve this function, most of the previous minimally invasive interventional occluder frames are woven from non-degradable nickel-titanium alloys, which can cause valve damage, atrioventricular block, heart tissue wear, etc. Complications such as thrombosis occur, and the risk of these complications affects patients throughout their lives. The use of degradable materials to prepare an occluder is an ideal choice to overcome these shortcomings. After implantation, it can induce the regeneration of cardiac defect tissue, and completely disappear after cardiac repair. It will not adversely affect the subsequent life of the patient. Ideal for defects and for LAA closure.

However, compared with the traditional occluder made of nickel-titanium alloy material, the current minimally invasive interventional degradable occluder cannot be visualized under X-rays, which is inconvenient for doctors to transport and release the occluder. This problem is solved by adding developing marks on the occluder, but the developing marks are generally non-degradable metals, which will permanently remain in the body and cause foreign body reactions, and in order to minimize the residue of the developing marks, often only a small number of parts of the occluder can be marked. The overall release profile of the occluder cannot be assessed, increasing the risk of surgery for the patient. Therefore, there is an urgent need to solve the technical problem that the imaging mark will remain permanently in the body, and only a small number of parts of the occluder can be marked.

SUMMARY OF THE INVENTION

Based on this, the object of the present invention is to provide a developing wire, which can be withdrawn in vitro after the occluder is released, can avoid the permanent residue of the developing mark in the body, and can expand the developing range at the same time, which is beneficial to reduce the difficulty and risk of surgery, And it has low elastic modulus and friction resistance, and has good compliance, and the end of the developing wire will not cause damage to the tissue when withdrawing.

The specific technical solutions are as follows:

A developing wire, comprising a wire main body and a first control end and a second control end arranged on the wire main body for picking and placing the wire main body, the first control end and the second control end are respectively located at both ends of the wire main body ;

The material of the developing wire is a polymer wire with a lubricating layer on the surface, and the lubricating layer supports the developing material; or the developing wire is a hydrogel wire carrying the developing material.

In some of these embodiments, the polymer wire with a lubricating layer on the surface is prepared by comprising the following steps:

(1) Loading a double bond polymerizable precursor on the surface of the polymer wire material;

(2) coating double bond polymerizable monomer and initiator on the surface of the wire material obtained in step (1) again;

(3) then solidify the wire material obtained in step (2);

Wherein, introducing developing material in step (1) or (2);

The polymer wire is at least one of polypropylene wire, polytetrafluoroethylene wire and polyamide wire; the double bond polymerizable precursor is methacrylamide compound, methacrylate At least one of compounds, acrylates, acrylamide compounds, acryloyl chloride, and methacrylic anhydride;

The double bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfonic acid acrylic acid. kind.

In some embodiments, the methacrylamide compound is N-(3-aminopropyl) methacrylamide hydrochloride.

In some of these embodiments, the surface-loaded developing material and lubricating material polymer wire is prepared by comprising the following steps:

(2) Immerse the filament obtained in step (1) in an aqueous solution containing a double bond polymerizable monomer and an initiator for 5-15 minutes.

(3) then solidify the wire material obtained in step (2);

In some embodiments, the concentration of the double bond polymerizable monomer in the aqueous solution containing the double bond polymerizable monomer and the initiator is 0.2 wt % to 50 wt %, and the concentration of the initiator is 0.05 wt % to 2 wt %.

In some of these embodiments, in step (1), the double bond polymerizable precursor supported on the surface of the polymer filament material includes method A or method B:

Method A is: under alkaline or neutral conditions, coat the surface of the polymer wire with cross-linkable functional group molecules, and then coat the double bond polymerizable precursor; or coat the cross-linkable functional group molecule with the double bond polymerizable precursor The body is mixed and then coated;

Wherein, the crosslinkable functional group molecule is a tea polyphenol compound, preferably the tea polyphenol compound is at least one of tannic acid, epigallocatechin gallate, and dopamine;

Method B is: the surface of the polymer wire is subjected to plasma treatment (introduction of hydroxyl groups), and the double bond polymerizable precursor is coated.

In some of the embodiments, method A is: immersing the polymer wire in an aqueous solution containing cross-linkable functional group molecules, adjusting the pH to 7-10, soaking for 4-8 hours, taking out the wire, cleaning and immersing the The double bond polymerizable precursor is soaked in the aqueous solution for 4 to 8 hours, and the wire is taken out.

In some of the embodiments, method B is: plasma treatment (introduction of hydroxyl groups) on the surface of the polymer wire material, immersion in a diethyl ether solution of triethylamine, adding the double bond polymerizable precursor at 0-4° C., The reaction was carried out at room temperature for 20 to 30 hours, and the filament was taken out.

In some embodiments, in method A, the concentration of the crosslinkable functional group molecules in the aqueous solution containing the crosslinkable functional group molecules is 1-10 mg/mL; preferably, the concentration of the double bond polymerizable precursor in the aqueous solution It is 0.5～10mg/mL.

In some of these embodiments, in Method B: the concentration of the double bond polymerizable precursor in the solution is 5-15 v/v %.

In some of these embodiments, the initiator is a photoinitiator, further Irgacure 2959.

In some of these embodiments, the curing method in step (3) is photocuring.

In some of these embodiments, the aqueous solution of the double bond-containing polymerizable monomer and the initiator in step (2) may further include a crosslinking agent. Further, the crosslinking agent contains at least two polymerizable functional groups, such as polyethylene glycol diacrylate and N,N'-methylenebisacrylamide.

In some embodiments, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, and rhodium; further, the developing material is tungsten nanoparticles, tantalum nanoparticle At least one of particles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles, and rhodium nanoparticles.

In some of these embodiments, the base is sodium hydroxide or triethylamine.

In some of the embodiments, the coating method is dip coating, wipe coating or spray coating.

In some of these embodiments, the developing material-loaded hydrogel thread is prepared by comprising the steps of:

(1) dispersing the developing material in an aqueous solution of cross-linkable functional group molecules to obtain a developing material modified by cross-linkable functional group molecules;

(2) placing the developing material obtained in step (1) in the gel precursor aqueous solution, and injecting it into the mold to solidify to obtain a hydrogel developing line;

Wherein, the gel precursor is polyvinyl alcohol; the crosslinkable functional group molecule is a tea polyphenol compound, preferably the crosslinkable functional group molecule is tannic acid, epigallocatechin gallate, and dopamine. at least one.

In some of the embodiments, in the aqueous solution of the crosslinkable functional group molecules in step (1), the concentration of the crosslinkable functional group molecules is 5-15 mg/mL.

In some of these embodiments, the concentration of the gel precursor in the aqueous gel precursor solution is 20-40 wt%.

In some of these embodiments, the concentration of the developing material in the aqueous gel precursor solution is 0.1-20 mg/mL.

In some of these embodiments, the pH of the aqueous solution of the crosslinkable functional group molecule is 8-10.

In some of these embodiments, the mold is a cylindrical mold.

In some of these embodiments, the diameter of the cylindrical mold is 0.1-0.3 mm.

In some of these embodiments, the curing in step (2) is repeated freezing and thawing more than 3 times.

In some embodiments, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, and rhodium; further, the developing material is tungsten nanoparticles, tantalum At least one of nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles, and rhodium nanoparticles.

Another object of the present invention is to provide an occluder with a developing function, comprising a support body and a developing wire, wherein the developing wire is the above-mentioned developing wire.

In some embodiments, the occluder includes a support body in a mesh structure and a first development wire, the first development wire is detachably disposed on the support body, and the first development wire includes a first development wire. a control end, a second control end and a first developing section, the first control end and the second control end are respectively located at two ends of the first developing section, the first developing section is located in the support body, the The support body is provided with a first end portion, and both the first control end and the second control end protrude from the first end portion.

In some of the embodiments, the support body includes a first disk body, a second disk body and a connecting waist body, the connecting waist body is located between the first disk body and the second disk body, the The first end is located on the first disc body, and the support body is further provided with a first winding part, a second winding part, a third winding part and a fourth winding part, the first winding part The wrapping portion is located between the first disc body and the connecting waist, the second wrapping portion is located between the second disc body and the connecting waist, and the third wrapping portion and the first wrapping portion are symmetrically arranged, so The fourth winding part and the second winding part are symmetrically arranged.

In some of the embodiments, the support body is further provided with a second end portion, the second end portion is located on the second disk body, and the second end portion is disposed corresponding to the first end portion.

In some of the embodiments, a second developing wire is further included, and the first developing wire passes through the first end, the first passing part, the second passing part, the second end, the third passing The four winding parts are arranged on the support body to form a first plane, the second developing wire is detachably arranged on the support body to form a second plane, and the first plane and the second plane are at a 90° angle Angle setting.

In some embodiments, the second developing wire includes a third control end, a fourth control end and a second developing section, and the third control end and the fourth control end are respectively located at two ends of the second developing section. Both the third control end and the fourth control end protrude from the first end of the support body.

In some of these embodiments, the control end of the developing wire is not its own end, but an additional control wire is connected to any part of the main body of the developing wire, one end of the control wire is connected to the main body of the developing wire, and the other end is connected from the occluder to the main body of the developing wire. Extending out and extending to the outside of the body, preferably, the control wire is connected to the midpoint part of the main body of the developing wire, and the movement of the developing wire can be controlled by the control wire.

In some of the embodiments, a flow blocking film is further included, the flow blocking film is sewn on the first disc body, the second disc body and the connecting waist respectively, and the flow blocking film is provided with multiple layers.

In some embodiments, the material of the support body is prepared from degradable materials, including at least one degradable material selected from polylactic acid, polyglycolic acid, polycaprolactone, polyacid anhydride, and polydioxanone made.

Compared with the prior art, the present invention has the following beneficial effects:

The developing wire provided by the present invention can be detachably arranged on the support body of the mesh structure. During the process of putting the occluder into the human body, the developing wire can be fixed on the support body, and the occluder can be developed under X-rays. , it is convenient for doctors to transport and release the occluder; at the same time, the development segment is located on the support body, which can expand the development range, which is conducive to evaluating the release form of the occluder, reducing the difficulty and risk of surgery; A control end or a second control end removes the developing wire from the occluder and withdraws it from the human body, so as to avoid the developing mark remaining in the body and causing a foreign body reaction and causing discomfort to the human body.

At the same time, in the actual application process, in order to solve the problem that the elastic modulus of the existing metal developing wire is too high, the material is hard, the compliance is poor, the winding and withdrawal are difficult, and the tip may cause damage to the tissue during withdrawal. Problem, the present invention also specially developed a specific developing wire material, that is, a polymer wire with a lubricating layer loaded with the developing material on the surface, or a hydrogel wire loaded with the developing material, which has a lower elastic modulus, Its elastic modulus is between 0.3-5Gpa, and the elastic modulus of the metal material exceeds 30Gpa, so that the development wire will not cause damage to the tissue during the withdrawal process, and the lubricating layer or hydrogel line on the surface of the development wire has good performance. The lubricity can make the developing wire have lower frictional resistance, thereby greatly reducing the resistance during the withdrawal process, and reducing possible accidental risks and related complications during the withdrawal process.

Description of drawings

The accompanying drawings here show specific examples of the technical solutions of the present invention, and form a part of the specification together with the specific embodiments, and are used to explain the technical solutions, principles and effects of the present invention.

Unless otherwise specified or otherwise defined, in different drawings, the same reference numerals represent the same or similar technical features, and the same or similar technical features may also be represented by different reference numerals.

FIG. 1 is a schematic structural diagram of a support body according to an embodiment of the present invention.

Fig. 2 is the structural schematic diagram that the developing wire of the embodiment of the present invention is put into the support main body;

FIG. 3 is a schematic structural diagram of a control wire according to an embodiment of the present invention.

Description of reference numbers:

10. Supporting body; 11. First end; 12. Second end; 13. Third wrapping part; 14. Fourth wrapping part; 15. Third wrapping part; 16. Fourth wrapping part 20, the first development wire; 21, the first control end; 22, the second control end; 23, the first development section; 30, the second development wire; 31, the third control end; 32, the fourth control end; 33. Second developing section; 50. Control wire; 51. Operation end. .

Detailed ways

The experimental methods that do not specify specific conditions in the following examples of the present invention are usually in accordance with conventional conditions, or in accordance with the conditions suggested by the manufacturer. Various common chemical reagents used in the examples are all commercially available products.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terms used in the description of the present invention are only for the purpose of describing specific embodiments, and are not used to limit the present invention.

The terms "comprising" and "having" and any variations thereof of the present invention are intended to cover a non-exclusive inclusion. For example, a process, method, apparatus, product or device comprising a series of steps is not limited to the listed steps or modules, but optionally also includes unlisted steps, or optionally also includes steps for these processes, other steps inherent in the method, product or device.

The "plurality" mentioned in the present invention means two or more. "And/or", which describes the association relationship of the associated objects, means that there can be three kinds of relationships, for example, A and/or B, which can mean that A exists alone, A and B exist at the same time, and B exists alone. The character "/" generally indicates that the associated objects are an "or" relationship.

It should be noted that when an element is considered to be "fixed" to another element, it may be directly fixed to the other element, or it may be an intervening element; when an element is considered to be "connected" to another element, it may be It may be directly connected to another element, or there may be intervening elements; when an element is considered to be "mounted" on another element, it may be directly mounted to the other element, or an intervening element may be present. When an element is referred to as being "disposed on" another element, it can be directly disposed on the other element or intervening elements may also be present.

Unless specifically stated or otherwise defined, the "said" and "the" used herein are the technical features or technical contents mentioned or described before the corresponding position, the technical features or technical contents and the technical features or technical contents mentioned above. The technical content can be the same or similar.

Undoubtedly, technical content or technical features that go against the purpose of the present invention, or are obviously contradictory, should be excluded.

As shown in FIG. 1 and FIG. 2 , the present invention provides a developing wire 20 , which includes a wire body and a first control end 21 , a second control end 22 and a first control end 21 and a second control end 22 disposed on the wire body for picking and placing the wire body. the first developing segment 23, the first control end 21 and the second control end 22 are respectively located at two ends of the first developing segment 23;

Compared with the previous metal developing wire, the developing wire prepared by using polymer wire or hydrogel wire has a lower elastic modulus, which is more conducive to the development of the developing wire to be wound and fixed on the occluder, and at the same time, it avoids the withdrawal caused by the high elastic modulus. In the process of extraction, the developing silk may cause damage to the tissue, thereby helping to protect the human tissue.

Preferably, the polymer wire with a lubricating layer on the surface is prepared by comprising the following steps:

(3) then solidify the wire material obtained in step (2);

Wherein, introducing developing material in step (1) or (2);

The polymer wire is at least one of polypropylene wire, polytetrafluoroethylene wire and polyamide wire; the double bond polymerizable precursor is methacrylamide compound, methacrylate At least one of compounds, acrylates, acrylamide compounds, acryloyl chloride, and methacrylic acid anhydride, preferably the methacrylamide compound is N-(3-aminopropyl)methacrylamide hydrochloride; The double bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfonic acid acrylic acid. kind.

Among them, the double bond polymerizable precursor is tightly loaded on the surface of the polymer wire material to introduce double bonds without damaging the mechanical properties of the wire body; at the same time, the coated specific type of double bond polymerizable monomer is Under the action of the initiator, a cross-linked network with lubricating effect can be formed by itself to achieve a good lubricating effect, and the double bond introduced into the polymer wire can further participate in the copolymerization of the double bond polymerizable monomer, enhancing the lubricating effect of the polymer. The binding force of the cross-linked network and the polymer wire.

Further, the surface-loaded polymer wire material of the developer material and the lubricating material is prepared by comprising the following steps:

(3) then solidify the wire material obtained in step (2);

Preferably, the concentration of the double bond polymerizable monomer in the aqueous solution containing the double bond polymerizable monomer and the initiator is 0.2 wt % to 50 wt %, preferably 1 to 20 wt %, and more preferably 5 to 15 wt %. The concentration of the agent is 0.05wt%-2wt%, preferably 0.05wt%-1wt%, more preferably 0.05wt%-0.5wt%, further preferably 0.05wt%-0.2wt%.

Preferably, the initiator is a photoinitiator, further Irgacure 2959.

Preferably, the curing method in step (3) is photocuring.

Preferably, in step (1), the double bond polymerizable precursor supported on the surface of the polymer wire material comprises method A or method B:

Method A is: under alkaline or neutral conditions, coat the surface of the polymer wire with crosslinkable functional group molecules, and then coat the double bond polymerizable precursor, or coat the crosslinkable functional group molecule with the double bond polymerizable precursor The product is mixed and then coated; wherein, the crosslinkable functional group molecule is a tea polyphenol compound, preferably the tea polyphenol compound is at least one of tannin, epigallocatechin gallate, and dopamine. kind;

Among them, the method A is to coat the surface of the polymer wire with a specific type of cross-linkable photoenergy group molecules, and then coat the double bond polymerizable precursor. The coated specific types of cross-linkable photo-energy group molecules have strong adhesion to the polymer wire, and can be closely combined with the surface of the polymer wire, thereby realizing the introduction of double bonds or developing materials. Especially under alkaline conditions, the cross-linkable photoenergy group molecules can further undergo self-polymerization, so that they can better adhere to the polymer wire. At the same time, the specific type of cross-linkable photo-energy group molecule has an active reactive functional group, which can react with the double bond polymerizable precursor, and connect the two through a covalent bond to introduce a double bond, so as to tightly fix the double bond on the surface of the polymer wire.

Alternatively, the developing material may be introduced in step (1) or (2), or may be introduced simultaneously in step (1) or (2). Further, when the developing material is introduced in step (1), the developing material can be mixed with the crosslinkable functional group molecules; when the developing material is introduced in step (2), the developing material can be mixed with an initiator.

Further, method A is as follows: immersing the polymer wire in an aqueous solution containing crosslinkable functional group molecules, adjusting the pH to 7-10, soaking for 4-8 hours, taking out the wire, and immersing the polymer wire containing the double bond after cleaning. The precursor is soaked in the aqueous solution for 4 to 8 hours, and the filament is taken out.

Optionally, the polymer wire in method A can also be subjected to plasma treatment first, and then immersed in an aqueous solution containing molecules of cross-linkable functional groups.

Further, method B is as follows: plasma treatment (introduction of hydroxyl groups) is performed on the surface of the polymer wire, immersed in a diethyl ether solution of triethylamine, and the double bond polymerizable precursor is added at 0-4° C., and the reaction is carried out at room temperature for 20 minutes. ~30 hours, the filaments are removed.

Preferably, the concentration of the crosslinkable functional group molecules in the aqueous solution containing the crosslinkable functional group molecules is 1-10 mg/mL, preferably 3-7 mg/mL, more preferably 4-6 mg/mL, further 5 mg/mL The concentration of the double bond polymerizable precursor in the aqueous solution is 0.5-10 mg/mL, preferably 0.5-5 mg/mL, more preferably 0.5-2 mg/mL, more preferably 0.8-1.5 mg/mL.

Preferably, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, and rhodium. Further, the developing material is developing nanoparticles, and further the developing material is tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles , at least one of iridium nanoparticles and rhodium nanoparticles.

Preferably, the base is at least one of sodium hydroxide and triethylamine.

Preferably, the coating method is dipping or wiping or spraying.

Preferably, the hydrogel thread loaded with developing material is prepared by comprising the following steps:

(1) dispersing the developing material in a mixed solution of cross-linkable functional group molecules and alkali to obtain a developing material modified by cross-linkable functional group molecules;

Wherein, the gel precursor is polyvinyl alcohol; the crosslinkable functional group molecule is at least one of tannic acid, epigallocatechin gallate, and dopamine.

Among them, after the developing material is modified with crosslinkable functional group molecules, the dispersibility in the gel precursor aqueous solution is better, and at the same time, the crosslinkable functional group molecules on the developing material help to increase the hydrogen between the surface of the developing material and the gel precursor. bond to form a cross-linked hydrogel network of the developing material, wherein the introduction of the developing material (especially the developing nanoparticles) not only has the developing function, but also further enhances the mechanical strength of the hydrogel developing line.

Preferably, in the mixed solution of the crosslinkable functional group molecule and the base in step (1), the concentration of the crosslinkable functional group molecule is 5-15 mg/mL, more preferably 10 mg/mL.

Preferably, the concentration of the gel precursor in the aqueous gel precursor solution is 20-40 wt %, more preferably 25-35 wt %, and more preferably 30 wt %.

Preferably, the concentration of the developing material in the gel precursor aqueous solution is 5-20 mg/mL, more preferably 5-15 mg/mL, and more preferably 10 mg/mL.

Preferably, the mold is a cylindrical mold, and the diameter of the cylindrical mold is 0.1-0.3 mm, more preferably 0.2 mm.

The present invention will be further described in detail below in conjunction with specific embodiments.

As shown in FIG. 1 and FIG. 2 , this embodiment further provides an occluder with a developing function, including a support body 10 and a developing wire 20 , and the developing wire is the above-mentioned developing wire.

Specifically, the occluder includes a support body 10 in a mesh structure and a first development wire 20 , the first development wire 20 is detachably disposed on the support body 10 , and the first development wire 20 includes The first control end 21 , the second control end 22 and the first developing segment 23 , the first control end 21 and the second control end 22 are respectively located at both ends of the first developing segment 23 , and the first developing segment 23 is located at the In the support body 10 , the support body 10 is provided with a first end portion 11 , and both the first control end 21 and the second control end 22 protrude from the first end portion 11 .

By dismounting the developing wire on the support body 10 of the mesh structure, during the process of putting the occluder into the human body, the developing wire can be fixed on the support body 10, and the occluder can be developed under X-ray, which is convenient for doctors The occluder is transported and released; at the same time, the development segment is located in the support body 10 to expand the development range. Compared with the previous only marking a small amount of the occluder, the entire development segment is more conducive to evaluating the release form of the occluder, reducing the difficulty of surgery. And the risk of surgery; when the occluder is released, the developing wire is removed from the occluder and withdrawn from the body by pulling the first control end 21 or the second control end 22, so as to avoid the development mark remaining in the body. Causes foreign body reaction and avoids discomfort to the human body; extending the first control end 21 and the second control end 22 from the first end 11 of the support body 10 is conducive to pulling the control developing wire to withdraw from the human body, and at the same time can prevent the developing wire It falls off from the occluder. It should be noted that the two control ends extend from the support body 10 to the outside of the body, so it is more convenient to withdraw the developing wire outside the body.

As shown in FIG. 1 and FIG. 2 , the support body 10 includes a first plate body, a second plate body and a connecting waist body, and the connecting waist body is located between the first plate body and the second plate body And form the "I"-shaped support body 10, the first end portion 11 is located on the first disc body, and the support body 10 is further provided with a first winding portion 13 and a second winding portion 14. , the third wrapping part 15, the fourth wrapping part 16 and the second end part 12, the first wrapping part 13 is located between the first disc body and the connecting waist body, and the second wrapping part 14 is located at the Between the second disc body and the connecting waist, the third wrapping portion 15 is symmetrically arranged with the first wrapping portion 13 along the central axis of the support body 10 , and the fourth wrapping portion 16 is also arranged along the axis of the support body 10 . The central axis is symmetrically arranged with the second winding portion 14 , the second end portion 12 is located on the second disc body, and the second end portion 12 is arranged corresponding to the first end portion 11 , wherein the first end portion 11 is The proximal end of the support body 10 is supported, and the second end portion 12 is the distal end of the support body 10 . Since the position between the disc body and the connecting waist is the position with the highest degree of bending deformation on the occluder, the wrapping part is arranged between the disc body and the connecting waist, so that the developing wire can better fit the contour of the supporting body 10 and improve the performance of the occluder. At the same time, by setting multiple winding parts, the developing wire is not easy to loosen from the occluder during the process of sending the occluder into the human body, so as to ensure normal development and smooth insertion of the occluder.

The following is an embodiment of the detachable arrangement of the first developing wire 20 in the above-mentioned supporting body 10:

The first developing wire 20 starts from the grid of the first end portion 11 of the support body 10, extends toward the side close to the second end portion 12, first extends to the first winding portion 13, and is wound around the first winding portion 13. The mesh of the second winding part 13 extends to the second winding part 14 and the mesh of the second winding part 15, then extends to the second end part 12, and after passing through the mesh of the second end part 12, It extends back toward the side close to the first end 11 , and then extends to the third winding part 15 , and after passing through the mesh of the third winding part 15 , extends to the fourth winding part 16 , and finally wears The mesh around the fourth wrap-around portion 16 extends back to and from the first end portion 11 . The first developing wire 20 is detachably arranged on the support body 10 by the above-mentioned method of weaving and weaving, so as to expand the developing range of the first developing wire 20 in the occluder, and can roughly develop the outline of the entire occluder. In the past, the development mark was only located in individual parts of the occluder, resulting in incomplete development, which is conducive to adjusting the release position of the occluder and grasping the release state of the occluder, reducing the difficulty of the doctor's operation and reducing the risk of the patient's operation. It should be noted that the above threading and weaving method of the developing wire is only one of the preferred embodiments, which can realize rapid threading and development of the basic outline of the occluder, but according to the development requirements of the occluder, Different winding parts are positioned on the support body 10 to realize different winding ways.

In order to further improve the developing effect of the occluder, a second developing wire 30 is added. The second developing wire 30 includes a third control end 31, a fourth control end 32 and a second developing section 33. The third control end 31 and The fourth control ends 32 are respectively located at two ends of the second developing section 33 , and the third control ends 31 and the fourth control ends 32 both extend from the first end 11 of the support body 10 . The second developing wire 30 has the same structure as the first developing wire 20, and the third control end 31 and the fourth control end 32 are protruded from the first end 11 of the support body 10, which is convenient for pulling and controlling the second developing wire 30 to withdraw At the same time, it can prevent the second developing wire 30 from falling off the occluder. Similarly, it should be noted that the two control ends extend from the support body 10 to the outside of the body, and the developing wire withdrawal operation is performed outside the body. More convenient.

The first developing wire 20 is arranged on the support body 10 by the above-mentioned winding method to form a first plane, and the second developing wire 30 is detached and arranged according to the steps similar to the above-mentioned winding method. A second plane is formed on the support body 10, but different from the above-mentioned winding method, the second plane formed by the second developing wire 30 and the first plane formed by the first developing wire 20 are sandwiched at 90°. horn. Since the occluder is a three-dimensional device, setting the second plane and the first plane at an angle of 90° can more comprehensively display the overall outline of the occluder, improve the development effect, and avoid the displacement of the occluder during implantation. A developing angle of the developing wire 20 . However, it should be noted that the number of developing filaments and the number of plane angles formed by winding can be adjusted according to the actual situation.

The above method of withdrawing from the human body by pulling the control end of the developing wire is a preferred embodiment of the present invention. As shown in FIG. 3 , in one of the embodiments, a separate control wire 50 is also included, and the control wire 50 is arranged at Outside the support body 10, the control wire 50 and the development wire are connected to the position where the second end 12 of the support body 10 is wound, and the end of the control wire 50 away from the connection with the development wire is the operation end 51, wherein the operation end 51 extends outside the human body In addition, in order to prevent the control wire 50 from affecting the development wire to be smoothly wound on the occluder, the control wire 50 can be connected to the development wire after the development wire is set. After the release of the occluder is completed, by pulling the operating end 51 of the control wire 50, both ends of the developing wire 50 are simultaneously pulled out from the second end 12, which speeds up the removal and withdrawal of the developing wire from the occluder The speed of the human body, improve work efficiency.

The material of the support body 10 is a degradable material, and the degradable material is at least one material selected from the group consisting of polylactic acid, polyglycolic acid, polycaprolactone, polyacid anhydride and polydioxanone. The occluder made of degradable materials can avoid complications such as valve damage, atrioventricular block, heart tissue wear, and thrombosis caused by the residual body, which is more conducive to the recovery of surgery and avoids adverse effects on the patient's subsequent life.

The occluder is also provided with a blocking film (not shown in the figure), the blocking film is sewn on the first disc body, the second disc body and the connecting waist respectively, and the blocking film is provided with multiple Floor. The flow blocking film can be prepared from degradable polymer materials such as polylactic acid. Sewing the blocking film on the occluder is beneficial to promote the growth of the endothelium, making the endothelium easier to crawl, and speeding up the recovery of the patient.

Source of material:

Polyvinyl alcohol: Type 1799, weight average molecular weight 90,000.

Polyethylene glycol diacrylate: purchased from TCI, molecular weight 258.

Example 1. Preparation of occluder containing developing filaments

The "I"-shaped occluder skeleton is woven with poly-p-dicyclohexanone wire, and then the developing wire starts from the proximal end of the occluder, and passes through the gap in the skeleton along the axial direction of the occluder to reach the occluder. The distal apex of the occluder, then starts to pass through the gap toward the proximal end, and returns to the proximal apex, the path of the developing wire is symmetrically distributed along the central axis of the occluder, and finally the end of the developing wire is exposed to the body along the delivery system. According to similar steps, along the axial direction of the skeleton and in a direction of 90 degrees with the direction of the first developing wire, a second developing wire is inserted into the skeleton, and the end of the developing wire is exposed along the conveying system to in vitro. During the implantation process of the occluder, since the developing wire is located on the entire outline of the occluder skeleton, the entire occluder can be visualized, which avoids the fact that the development marks are only located in individual parts of the occluder and the development is incomplete. problem, better adjust the release position of the occluder and grasp the release state of the occluder. At the same time, the developing wire on the occluder can be separated and withdrawn from the occluder by controlling the end outside the body, so as to avoid the residue of the developing substance in the body.

Example 2. Hydrogel Coated Polypropylene Developer Filament

(1) Preparation of hyaluronic acid methacrylate: hyaluronic acid was dissolved in an aqueous solution (0.1 wt %), passed through a cation exchange resin, and then lyophilized. Then dissolve in DMSO solution, add methacrylic acid anhydride equivalent to 0.2 equivalent (mass ratio) of hyaluronic acid, react for 24 hours, add chloroform to the reaction solution to precipitate, dissolve the precipitate in water, dialyze it in a dialysis bag, freeze-dry it Hyaluronic acid methacrylate was obtained.

(2) The polypropylene wire was first soaked in a mixed aqueous solution of 5 mg/mL tannic acid and 1 mg/mL tungsten nanoparticles, and 1M sodium hydroxide was added to adjust the pH to 9. After soaking for 6 hours, the polypropylene wire was taken out and deionized. It was washed with water three times and then soaked in an aqueous solution (1 mg/mL) of N-(3-aminopropyl)methacrylamide hydrochloride (pH=8) for 6 hours. The polypropylene filament was taken out and washed with deionized water three times to obtain a polypropylene filament with surface-modified double bonds and developed nanoparticles. In this step, double bonds and developing nanoparticles can be introduced simultaneously on the surface of various filaments through simple steps without damaging the mechanical properties of the wire body. The developing nanoparticles have a larger surface area, which can further increase the introduction of double bonds. It can realize the development function at the same time, and the method does not need to pre-treat the wire.

(3) Soak the polypropylene filaments with surface modified double bonds and developed nanoparticles obtained in step (2) in an aqueous solution of 0.5wt% hyaluronic acid methacrylate and 0.1wt% Irgacure 2959 as a photoinitiator for 10 minutes, and take out the filaments under UV light. Cured under light. The hyaluronic acid methacrylate in this step can form a cross-linked network by itself under the polymerization of the initiator, so as to play a lubricating role, and the double bond on the surface of the polypropylene wire can simultaneously participate in the hyaluronic acid methacrylate The copolymerization of double bonds in the hyaluronic acid network enhances the bonding force between the hyaluronic acid network and the polypropylene wire.

Example 3. Hydrogel Coated Polypropylene Developer Filament

(1) Preparation of polyvinyl alcohol acrylate: 5.0 g of polyvinyl alcohol (PVA) was dissolved in 100 ml of dimethyl sulfoxide (DMSO). Dimethylaminopyridine and glycidyl acrylate were added in addition amounts of 1.0 mol% (relative to the hydroxyl groups of PVA) and 0.025 mol% (relative to the hydroxyl groups of PVA), respectively. Stir at 60 °C for 6 h, then add acetone to the reaction solution for precipitation, take the precipitate and vacuum dry for 2 days, and store at -5 °C in the dark.

(2) The polypropylene wire was first soaked in a mixed aqueous solution of 5 mg/mL tannic acid and 1 mg/mL tantalum nanoparticles, and 1M sodium hydroxide was added to adjust the pH to 9. After soaking for 6 hours, the polypropylene wire was taken out and deionized. It was washed with water three times and then soaked in an aqueous solution (1 mg/mL) of N-(3-aminopropyl)methacrylamide hydrochloride (pH=8) for 6 hours. The polypropylene filament was taken out and washed with deionized water three times to obtain a polypropylene filament with surface-modified double bonds and developed nanoparticles. In this step, double bonds and developing nanoparticles can be simultaneously introduced on the surface of polypropylene wire through a simple step, without causing damage to the mechanical properties of the wire body. The developing nanoparticles can further increase the introduction amount of double bonds and realize the developing function at the same time, and the method does not need to pre-treat the wire.

(3) Soak the polypropylene filaments with surface-modified double bonds and developed nanoparticles obtained in step (2) in 1wt% polyvinyl alcohol acrylate and 0.1wt% Irgacure 2959 aqueous solution of photoinitiator for 10 minutes, take out and carry out under ultraviolet light cured. In this step, the polyvinyl alcohol acrylate can be polymerized under the action of the initiator to form a cross-linked network by itself, so as to play a lubricating role, and the double bond on the surface of the polypropylene wire can simultaneously participate in the double bond of the polyvinyl alcohol acrylate. Bond copolymerization, thereby enhancing the bonding force between the polyvinyl alcohol hydrogel network and the polypropylene filament.

Example 4. Polymer-Coated PTFE-Developed Filament

(1) The polytetrafluoroethylene wire was first soaked in an aqueous solution of 5 mg/mL epigallocatechin gallate and 1 mg/mL barium sulfate nanoparticles, 1M sodium hydroxide was added to adjust the pH to 9, soaked for 6 hours, and taken out Polypropylene filaments, washed three times with deionized water, and then soaked in an aqueous N-(3-aminopropyl)methacrylamide hydrochloride solution (1 mg/mL) (pH=8) for 6 hours. The polypropylene wire was taken out and washed three times with deionized water to obtain a polytetrafluoroethylene wire with surface-modified double bonds and developed nanoparticles. In this step, double bonds and developing nanoparticles can be simultaneously introduced on the surface of the polytetrafluoroethylene wire through a simple step, without causing damage to the mechanical properties of the wire body.

(2) Soak the polytetrafluoroethylene wire with surface modified double bonds and developed nanoparticles obtained in step (2) in 10 wt % vinylpyrrolidone and 0.1 wt % Irgacure 2959 aqueous solution as a photoinitiator for 10 minutes, take out and cure under ultraviolet light . The vinylpyrrolidone monomer in this step can be polymerized under the action of the initiator to form polyvinylpyrrolidone by itself, which has good hydrophilicity and lubricity. At the same time, the double bond on the surface of the wire also participates in the polymerization of vinylpyrrolidone. The binding force with the substrate is enhanced, and the double bond epigallocatechin gallate of the lower layer of the polyvinylpyrrolidone also produces hydrogen bonding, which further enhances the binding force with the substrate.

Example 5. Polymer-Coated Teflon Developer Filament

(1) The polytetrafluoroethylene wire was first soaked in an aqueous solution of 5 mg/mL dopamine and 1 mg/mL barium sulfate nanoparticles, and 1M sodium hydroxide was added to adjust the pH to 8.5. After soaking for 6 hours, the polypropylene wire was taken out and deionized. Washed with water three times, then soaked in N-(3-aminopropyl)methacrylamide hydrochloride aqueous solution (1 mg/mL) (pH=8) for 6 hours. The tetrafluoroethylene wire was taken out and washed with deionized water three times to obtain a polytetrafluoroethylene wire with surface-modified double bonds and developed nanoparticles. In this step, double bonds and developing nanoparticles can be simultaneously introduced on the surface of the polytetrafluoroethylene wire through a simple step, without causing damage to the mechanical properties of the wire body.

(2) Soak the polytetrafluoroethylene wire with surface modified double bonds and developed nanoparticles obtained in step (2) in 10wt% sulfobetaine methacrylate and 0.1wt% Irgacure 2959 aqueous solution of photoinitiator for 10 minutes, take out Cure under UV light. The sulfobetaine methacrylate monomer in this step can be polymerized under the action of an initiator to form a zwitterionic hydrogel, which has good hydrophilicity, lubricity and anticoagulant properties. The double bond of the hydrogel also participates in the polymerization of the hydrogel, which enhances the bonding force between the hydrogel and the substrate.

Example 6. Hydrogel-coated PTFE developing filament

(1) The PTFE wire was first treated with plasma surface, soaked in an aqueous solution of 5 mg/mL dopamine and 1 mg/mL barium sulfate nanoparticles, added 1M sodium hydroxide to adjust the pH to 8.5, soaked for 6 hours, and then took out the polypropylene The filaments were washed three times with deionized water, and then soaked in an aqueous N-(3-aminopropyl)methacrylamide hydrochloride solution (1 mg/mL) (pH=8) for 6 hours. The polytetrafluoroethylene wire is taken out and washed three times with deionized water. In this step, double bonds and developing nanoparticles can be simultaneously introduced on the surface of the polytetrafluoroethylene wire without damaging the mechanical properties of the wire body.

(2) Soak for 10 minutes in an aqueous solution of 10 wt % sulfonic acid acrylic acid, 0.5 wt % polyethylene glycol diacrylate and 0.1 wt % Irgacure 2959 photoinitiator, take out and cure under ultraviolet light. In this step, the sulfonic acid acrylic monomer and polyethylene glycol diacrylate can be polymerized under the action of the initiator to form an anionic hydrogel, which has good hydrophilicity, lubricity and anticoagulant properties. The double bond on the surface of the material also participates in the polymerization of the hydrogel, which enhances the bonding force between the hydrogel and the substrate.

Example 7. Hydrogel Coated Polyamide Developer Filament

(1) First, perform plasma treatment on the surface of the polyamide wire to introduce hydroxyl groups, then soak it in an ether solution containing 8wt% triethylamine, add 10% volume fraction of acryloyl chloride at zero degrees, and react at room temperature for 24 After 1 hour, take out the polypropylene filament and wash it three times with deionized water. This step can introduce double bonds on the surface of the polyamide through simple steps.

(2) The polypropylene filaments with surface-modified double bonds and developed nanoparticles obtained in step (1) were photoinitiated in a 1 wt % hyaluronic acid methacrylate aqueous solution, a 1 mg/mL aqueous solution of bismuth nanoparticles, and 0.1 wt % Soak for 10 minutes in Irgacure 2959 aqueous solution, take out and cure under UV light. In this step, the hyaluronic acid methacrylate can be polymerized under the action of an initiator to form a hydrogel, and at the same time, the developing nanoparticles are encapsulated in the hydrogel, which has good lubricity and developing performance. The double bonds on the surface also participate in the polymerization of the hydrogel, which enhances the bonding force between the hydrogel and the substrate.

Example 8 Hydrogel developing silk

0.01 g of tantalum nanoparticles were ultrasonically dispersed in 10 ml of a 10 mg/mL tannic acid aqueous solution, and sodium hydroxide solution was added to adjust the pH to 9. After 6 hours of reaction, the solution was centrifuged to obtain tannic acid-modified tantalum nanoparticles. The obtained tannic acid-modified tantalum nanoparticles were added to a 30 wt% polyvinyl alcohol aqueous solution for dispersion, with a final concentration of 10 mg/mL. The obtained solution was injected into a cylindrical mold with a diameter of 0.2 mm, and was placed in a freezer at -20 degrees for 24 hours. Then take out and dissolve, repeat freeze-thaw three times to obtain nanoparticle-enhanced hydrogel development lines. In the developing lines obtained by this technology, the nanoparticles are surface-modified with tannic acid, so they have better dispersibility in the polyvinyl alcohol solution, and the tannic acid on the nanoparticles helps to increase the hydrogenation of the nanoparticles in the polyvinyl alcohol. Bonding to form a cross-linked hydrogel network of nanoparticles, in which the introduction of nanoparticles not only has the function of developing, but also further enhances the mechanical strength of the hydrogel developing line.

Comparative Example 1

A developing wire, the preparation method is as follows: the polypropylene wire is first soaked in a mixed aqueous solution of 5 mg/mL tannic acid and 1 mg/mL tungsten nanoparticles, adding 1 M sodium hydroxide to adjust the pH to 9, soaking for 6 hours, and taking out the Acrylic wire, washed three times with deionized water.

Comparative Example 2

A developing wire, which is polypropylene wire without treatment.

Comparative Example 3

A developing wire is a nickel-titanium alloy wire with a diameter of 0.2 mm.

Withdrawal force and elastic modulus testing

The developing filaments of Examples 2-8 and Comparative Examples 1-3 were wound into the same occluder by the method described in Example 1. After the occluder was transported and released, one end of the developing material was fixed by a tension machine, and the developing filament was withdrawn. , to test its withdrawal force. From the results in Table 1 below, it can be seen that the developed filaments of Examples 2-8 of the present invention have low withdrawal force and elastic modulus. The coating on the surface of the polymer wire does not have a significant effect on the modulus of the polymer wire, and after the surface is polymerized with monomers, the withdrawal force of the developing wire is significantly reduced.

Table 1

显影丝编号Development wire number	撤回力Withdrawal force	弹性模量Elastic Modulus
实施例2Example 2	0.10N0.10N	1.7Gpa1.7Gpa
实施例3Example 3	0.15N0.15N	1.8Gpa1.8Gpa
实施例4Example 4	0.11N0.11N	1.2Gpa1.2Gpa

实施例5Example 5	0.21N0.21N	1.1Gpa1.1Gpa
实施例6Example 6	0.17N0.17N	1.1Gpa1.1Gpa
实施例7Example 7	0.11N0.11N	7.2Gpa7.2Gpa
实施例8Example 8	0.18N0.18N	0.8Gpa0.8Gpa
对比例1Comparative Example 1	0.53N0.53N	1.7Gpa1.7Gpa
对比例2Comparative Example 2	0.45N0.45N	1.7Gpa1.7Gpa
对比例3Comparative Example 3	2.7N2.7N	55Gpa55Gpa

The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity, all possible combinations of the technical features in the above-described embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, All should be regarded as the scope described in this specification.

The above-mentioned embodiments only represent several embodiments of the present invention, and the descriptions thereof are specific and detailed, but should not be construed as a limitation on the scope of the invention patent. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can also be made, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention should be subject to the appended claims.

Claims

A developing filament is characterized in that it comprises a filament body and a first control end and a second control end arranged on the filament body for picking and placing the filament body, wherein the first control end and the second control end are respectively located on the filament body. both ends of the main body;

The material of the developing wire is a polymer wire with a lubricating layer on the surface, and the lubricating layer supports the developing material; or the developing wire is a hydrogel wire that supports the developing material;

The polymer wire with lubricating layer on the surface is prepared by comprising the following steps:

(1) Loading a double bond polymerizable precursor on the surface of the polymer wire material;

(2) coating double bond polymerizable monomer and initiator on the surface of the wire material obtained in step (1) again;

(3) then solidify the wire material obtained in step (2);

Wherein, introducing developing material in step (1) or (2);

The polymer wire is at least one of polypropylene wire, polytetrafluoroethylene wire and polyamide wire;

The double bond polymerizable precursor is at least one of methacrylamide compounds, methacrylate compounds, acrylates, acrylamide compounds, acryloyl chloride, and methacrylic acid anhydride,

The double bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfonic acid acrylic acid. kind;

The hydrogel line loaded with developing material is prepared by comprising the following steps:

(1) dispersing the developing material in an aqueous solution of cross-linkable functional group molecules to obtain a developing material modified by cross-linkable functional group molecules;

(2) placing the developing material obtained in step (1) in the gel precursor aqueous solution, and injecting it into the mold to solidify to obtain a hydrogel developing line;

Wherein, the gel precursor is polyvinyl alcohol; and the crosslinkable functional group molecule is a tea polyphenol compound.
The developing filament according to claim 1, wherein the polymer filament with a lubricating layer on the surface is prepared by comprising the following steps:

(1) Loading a double bond polymerizable precursor on the surface of the polymer wire material;

(2) immersing the wire obtained in step (1) in an aqueous solution containing a double bond polymerizable monomer and an initiator for 5-15 minutes;

(3) then solidify the wire material obtained in step (2);

The concentration of the double bond polymerizable monomer in the aqueous solution containing the double bond polymerizable monomer and the initiator is 0.2wt% to 50wt%, and the concentration of the initiator is 0.05wt% to 2wt%.
The developing filament according to claim 1, characterized in that, in step (1), the double bond polymerizable precursor loaded on the surface of the polymer filament material comprises method A or method B:

Method A is: under alkaline or neutral conditions, coat the surface of the polymer wire with crosslinkable functional group molecules, and then coat the double bond polymerizable precursor, or coat the crosslinkable functional group molecule with the double bond polymerizable precursor Body mixed and then coated;

In method A, the crosslinkable functional group molecule is a tea polyphenol compound;

Method B is: the surface of the polymer wire is treated by plasma, and the double bond polymerizable precursor is coated.
The developing filament according to claim 3, wherein the method A is: immersing the polymer filament in an aqueous solution containing crosslinkable functional group molecules, adjusting the pH to 7-10, soaking for 4-8 hours, and taking out the filament , after cleaning, immerse in the aqueous solution containing the double bond polymerizable precursor, soak for 4 to 8 hours, and take out the wire;

Or, method B is: the surface of the polymer wire is subjected to plasma treatment by introducing hydroxyl groups, immersed in a diethyl ether solution of triethylamine, and the double bond polymerizable precursor is added at 0-4°C, and the reaction is carried out at room temperature for 20-30 hours, remove the filament.
The developing filament according to claim 4, wherein the concentration of the crosslinkable functional group molecules in the aqueous solution containing the crosslinkable functional group molecules is 1-10 mg/mL; the double bond polymerizable precursor is in the aqueous solution. The concentration of 0.5 ~ 10mg/mL.
The developing filament according to any one of claims 1 to 5, wherein the initiator is a photoinitiator;

And/or, the method for curing described in step (3) is photocuring;

And/or, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, rhodium; and/or, the coating method is dip coating or rubbing painted or sprayed.
The developing silk according to claim 6, is characterized in that, described initiator is Irgacure 2959.
The developing filament according to claim 1, wherein the crosslinkable functional group molecule in the hydrogel thread carrying the developing material is at least one of tannic acid, epigallocatechin gallate, and dopamine. A sort of.
The developing silk according to claim 8, wherein in the aqueous solution of the crosslinkable functional group molecules in step (1), the concentration of the crosslinkable functional group molecules is 5-15 mg/mL;

And/or, the concentration of the gel precursor in the gel precursor aqueous solution is 20-40 wt%, and the concentration of the developing material in the gel precursor aqueous solution is 0.1-20 mg/mL;

And/or, the mold is a cylindrical mold, and the diameter of the cylindrical mold is 0.1-0.3 mm;

And/or, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, and rhodium.
The developing wire according to claim 9, wherein the developing material is tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles At least one of particles, iridium nanoparticles, and rhodium nanoparticles.
The developing filament according to claim 1, wherein the methacrylamide compound is N-(3-aminopropyl) methacrylamide hydrochloride.
The developing silk according to claim 3, wherein the tea polyphenol compound is at least one of tannic acid, epigallocatechin gallate, and dopamine.
The developing filament according to claim 6, wherein the developing material is tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles At least one of particles, iridium nanoparticles, and rhodium nanoparticles.
An occluder with a development function is characterized in that it comprises a support body and a development wire, and the development wire is the development wire according to any one of claims 1 to 13 .