CN113081312B

CN113081312B - Developing wire and plugging device with developing function

Info

Publication number: CN113081312B
Application number: CN202110335915.8A
Authority: CN
Inventors: 王云兵; 郭高阳; 杨立
Original assignee: Sichuan University
Current assignee: Shanghai Shape Memory Alloy Material Co Ltd
Priority date: 2021-03-29
Filing date: 2021-03-29
Publication date: 2022-04-15
Anticipated expiration: 2041-03-29
Also published as: WO2022206148A1; NL2031176B1; CN113081312A; NL2031176A

Abstract

The invention relates to a developing wire and a plugging device with a developing function. The developing wire comprises a wire main body, a first control end and a second control end, wherein the first control end and the second control end are arranged on the wire main body and used for taking and putting the wire main body; the developing wire is made of a high-molecular wire material with a lubricating layer arranged on the surface, and the lubricating layer loads a developing material; or the developing wire is a hydrogel line carrying a developing material. The developing silk can be operated and withdrawn in vitro after the occluder is released, can avoid the developing mark from remaining in vivo permanently, can expand the developing range, is beneficial to reducing the operation difficulty and the operation risk, has lower elastic modulus and frictional resistance, and can not damage the tissue by the end of the developing silk when being withdrawn.

Description

Developing wire and plugging device with developing function

Technical Field

The invention relates to the field of medical instruments, in particular to a developing wire and a plugging device with a developing function.

Background

Common congenital heart diseases are Atrial Septal Defects (ASD), Ventricular Septal Defects (VSD), Patent Ductus Arteriosus (PDA), Patent Foramen Ovale (PFO) and other heart site defects, and the congenital heart defects can cause heart dysfunction and other cardiovascular and cerebrovascular complications. In addition, the decreased atrial contraction of patients with atrial fibrillation leads to a further decrease in the blood flow rate in the left atrial appendage connected to the left atrium, which results in the clotting of blood into thrombus. If the thrombus is fallen off, the thrombus is likely to reach intracranial vessels through blood flow, and small cerebral vessels are blocked, so that ischemic stroke is caused. The occluder can be implanted into the heart full damage part or the left auricle part in a minimally invasive intervention mode, and the method is a preferred treatment scheme for patients with congenital heart diseases due to slight trauma, safe operation and definite near-to-middle-stage treatment effect.

Most of frames of the minimally invasive interventional occluder clinically used at present are of a net structure, so that the minimally invasive interventional occluder is conveniently compressed on a conveying device, and shape and disease recovery and release are realized at a diseased part after the minimally invasive interventional occluder is conveyed into a body, so that an occlusion function is completed. In order to realize the function, most of the frames of the traditional minimally invasive interventional occluders are made of non-degradable nickel-titanium alloy by weaving, the non-degradable nickel-titanium alloy is left as foreign matters, which can cause complications such as valve injury, atrioventricular block, heart tissue abrasion, thrombus and the like, and the risks of the complications affect the life of a patient. The plugging device prepared from degradable materials is an ideal choice for overcoming the defects, can induce the regeneration of the defective tissue of the heart after being implanted, completely disappears after the heart is repaired, cannot cause adverse effects on the subsequent life of a patient, and is an ideal choice for treating congenital heart defects and plugging the left atrial appendage.

However, compared with the traditional occluder made of nickel-titanium alloy materials, the existing minimally invasive interventional degradable occluder cannot be developed under X-rays, so that a doctor cannot conveniently convey and release the occluder. Therefore, the technical problems that the developing mark permanently remains in the body and only a small amount of parts of the occluder can be marked are to be solved.

Disclosure of Invention

Based on the above, the invention aims to provide a developing wire which can be operated and withdrawn in vitro after the occluder is released, can avoid the development mark from remaining in vivo permanently, can expand the development range, is beneficial to reducing the operation difficulty and the operation risk, has lower elastic modulus and frictional resistance and good compliance, and can prevent the end of the developing wire from damaging tissue during withdrawal.

The specific technical scheme is as follows:

a developing wire comprises a wire main body, a first control end and a second control end, wherein the first control end and the second control end are arranged on the wire main body and used for taking and putting the wire main body;

the developing wire is made of a high-polymer wire material of which the surface is provided with a lubricating layer, and the lubricating layer is loaded with a developing material; or the developing wire is a hydrogel line carrying a developing material.

In some embodiments, the polymer wire with the lubricating layer on the surface is prepared by the following steps:

(1) loading a double-bond polymerizable precursor on the surface of a high-molecular wire material;

(2) coating a double-bond polymerizable monomer and an initiator on the surface of the wire obtained in the step (1);

(3) then, solidifying the wire obtained in the step (2);

wherein a developing material is introduced in step (1) or (2);

the polymer wire is at least one of a polypropylene wire, a polytetrafluoroethylene wire and a polyamide wire; the double-bond polymerizable precursor is at least one of a methacrylamide compound, a methacrylate compound, acrylate, an acrylamide compound, acryloyl chloride and methacrylic anhydride;

the double-bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfoacrylic acid.

In some of these embodiments, the methacrylamide compound is N- (3-aminopropyl) methacrylamide hydrochloride.

In some embodiments, the polymer wire with the surface loaded with the developing material and the lubricating material is prepared by the following steps:

(2) and (2) soaking the wire obtained in the step (1) into an aqueous solution containing a double-bond polymerizable monomer and an initiator for 5-15 minutes.

(3) Then, solidifying the wire obtained in the step (2);

in some embodiments, the concentration of the double bond polymerizable monomer in the aqueous solution of the double bond-containing polymerizable monomer and the initiator is 0.2 wt% to 50 wt%, and the concentration of the initiator is 0.05 wt% to 2 wt%.

In some embodiments, the step (1) of loading the double bond polymerizable precursor on the surface of the polymer wire stock comprises a method A or a method B:

the method A comprises the following steps: under the alkaline or neutral condition, coating crosslinkable functional group molecules on the surface of the high-molecular wire, and then coating a double-bond polymerizable precursor; or the crosslinkable functional group molecules and the double-bond polymerizable precursor are mixed and then coated;

wherein the crosslinkable functional group molecule is a tea polyphenol compound, preferably the tea polyphenol compound is at least one of tannic acid, epigallocatechin gallate and dopamine;

the method B comprises the following steps: the surface of the polymer wire is treated by plasma (hydroxyl is introduced), and a double-bond polymerizable precursor is coated.

In some of these embodiments, method a is: and (3) immersing the high-molecular wire into an aqueous solution containing crosslinkable functional group molecules, adjusting the pH to 7-10, taking out the wire after immersing for 4-8 hours, cleaning, immersing into an aqueous solution containing the double-bond polymerizable precursor, and taking out the wire after immersing for 4-8 hours.

In some of these embodiments, the method B is: and (3) carrying out plasma treatment (hydroxyl introduction) on the surface of the polymer wire, soaking the polymer wire in an ether solution of triethylamine, adding the double-bond polymerizable precursor at 0-4 ℃, reacting for 20-30 hours at room temperature, and taking out the wire.

In some embodiments, in the method A, the concentration of the crosslinkable functional group molecules in the aqueous solution containing the crosslinkable functional group molecules is 1-10 mg/mL; preferably, the concentration of the double-bond polymerizable precursor in the aqueous solution is 0.5-10 mg/mL.

In some of these embodiments, the method B comprises: the concentration of the double-bond polymerizable precursor in the solution is 5-15 v/v%.

In some of these embodiments, the initiator is a photoinitiator, further Irgacure 2959.

In some of the embodiments, the curing method in step (3) is photocuring.

In some embodiments, the aqueous solution of the double bond-containing polymerizable monomer and the initiator of step (2) may further comprise a crosslinking agent. Further, the crosslinking agent is a molecule containing at least two polymerizable functional groups, such as polyethylene glycol diacrylate, N' -methylene bisacrylamide.

In some of these embodiments, the developer material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, rhodium; further, the developing material is at least one of tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles and rhodium nanoparticles.

In some of these embodiments, the base is sodium hydroxide or triethylamine.

In some of these embodiments, the coating is by dip coating or wiping or spraying.

In some of these embodiments, the developing material-bearing hydrogel thread is prepared by a process comprising:

dispersing the developing material in an aqueous solution of crosslinkable functional group molecules to obtain the developing material modified by the crosslinkable functional group molecules;

secondly, placing the developing material obtained in the first step into a gel precursor aqueous solution, injecting the gel precursor aqueous solution into a mold, and curing to obtain a hydrogel developing line;

wherein the gel precursor is polyvinyl alcohol; the crosslinkable functional group molecule is tea polyphenol compound, preferably at least one of tannic acid, epigallocatechin gallate and dopamine.

In some embodiments, the concentration of the crosslinkable functional group molecules in the aqueous solution of crosslinkable functional group molecules of step (one) is 5-15 mg/mL.

In some of these embodiments, the concentration of the gel precursor in the aqueous gel precursor solution is 20 to 40 wt%.

In some of these embodiments, the concentration of the developing material in the aqueous gel precursor solution is 0.1 to 20 mg/mL.

In some embodiments, the pH of the aqueous solution of the crosslinkable functional group molecule is 8 to 10.

In some of these embodiments, the mold is a cylindrical mold.

In some of the embodiments, the diameter of the cylindrical mold is 0.1-0.3 mm.

In some embodiments, the solidifying in step (two) is repeated freezing and thawing for more than 3 times.

In some of these embodiments, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, rhodium; further, the developing material is at least one of tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles and rhodium nanoparticles.

The invention also provides a plug with a developing function, which comprises a supporting main body and a developing wire, wherein the developing wire is the developing wire.

In some of these embodiments, the stopper includes a supporting main body and a first developing wire that are network structures, the first developing wire can be dismantled and set up in on the supporting main body, the first developing wire includes first control end, second control end and first developing section, first control end and second control end are located the both ends of first developing section respectively, first developing section is located in the supporting main body, be equipped with first tip on the supporting main body, first control end and second control end all stretch out from first tip.

In some embodiments, the supporting body includes a first tray body, a second tray body and a connecting waist body, the connecting waist body is located between the first tray body and the second tray body, the first end portion is located on the first tray body, the supporting body is further provided with a first threading and winding portion, a second threading and winding portion, a third threading and winding portion and a fourth threading and winding portion, the first threading and winding portion is located between the first tray body and the connecting waist body, the second threading and winding portion is located between the second tray body and the connecting waist body, the third threading and winding portion and the first threading and winding portion are symmetrically arranged, and the fourth threading and winding portion and the second threading and winding portion are symmetrically arranged.

In some embodiments, the support body is further provided with a second end portion, the second end portion is located on the second tray body, and the second end portion is arranged corresponding to the first end portion.

In some embodiments, the developing device further comprises a second developing wire, the first developing wire is arranged on the supporting main body through the first end portion, the first winding portion, the second end portion, the third winding portion and the fourth winding portion and forms a first plane, the second developing wire is detachably arranged on the supporting main body and forms a second plane, and the first plane and the second plane are arranged at an included angle of 90 degrees.

In some embodiments, the second developing wire includes a third control end, a fourth control end and a second developing section, the third control end and the fourth control end are respectively located at two ends of the second developing section, and the third control end and the fourth control end both extend out from the first end of the supporting body.

In some embodiments, the control end of the developing wire is not a self end, but a control wire is additionally connected to any part of the developing wire main body, one end of the control wire is connected with the developing wire main body, the other end of the control wire extends out of the body from the stopper, preferably, the control wire is connected with a midpoint part of the developing wire main body, and the movement of the developing wire can be controlled through the control wire.

In some embodiments, the waist connecting device further comprises a flow blocking film, the flow blocking film is respectively sewn on the first tray body, the second tray body and the waist connecting body, and the flow blocking film is provided with multiple layers.

In some embodiments, the material of the support body is made of degradable material, and the degradable material includes at least one of polylactic acid, polyglycolic acid, polycaprolactone, polyanhydride, and polydioxanone.

Compared with the prior art, the invention has the following beneficial effects:

the developing wire provided by the invention can be detachably arranged on the supporting main body of the net structure, the developing wire can be fixed on the supporting main body in the process of putting the plugging device into a human body, and the plugging device can be developed under X-ray, so that a doctor can conveniently convey and release the plugging device; meanwhile, the developing section is positioned on the supporting main body, so that the developing range can be expanded, the release form of the occluder can be evaluated, and the operation difficulty and the operation risk can be reduced; after the release of the occluder is finished, the developing wire is detached from the occluder and is withdrawn from the human body by controlling the first control end or the second control end, so that foreign body reaction caused by the residual developing mark in the human body is avoided, and discomfort to the human body is avoided.

Meanwhile, in the practical application process, in order to solve the problem that the elastic modulus of the existing metal developing wire is too high, and the material is hard, the compliance is poor, the threading and withdrawing are difficult, and the terminal can damage the tissue when withdrawing, the invention also specially develops the specific developing silk material, namely, a macromolecule wire material with a lubricating layer for loading a developing material on the surface or a hydrogel wire for loading the developing material is adopted, it has low elastic modulus of 0.3-5Gpa, while the elastic modulus of the metal material exceeds 30Gpa, so that the developing silk can not damage the tissue during withdrawing, and the lubricating layer or the hydrogel line on the surface of the developing silk has good lubricity, so that the developing silk has lower friction resistance, thereby greatly reducing resistance during withdrawal and reducing the potential for accidental risk and associated complications during withdrawal.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles and effects of the invention.

Unless otherwise specified or defined, the same reference numerals in different figures refer to the same or similar features, and different reference numerals may be used for the same or similar features.

Fig. 1 is a schematic structural diagram of a support body according to an embodiment of the invention.

FIG. 2 is a schematic view of a developing wire being placed in a supporting body according to an embodiment of the present invention;

fig. 3 is a schematic structural diagram of a control wire according to an embodiment of the present invention.

Description of reference numerals:

10. a support body; 11. a first end portion; 12. a second end portion; 13. a third through winding part; 14. a fourth through winding part; 15. a third through winding part; 16. a fourth through winding part; 20. a first developing wire; 21. a first control terminal; 22. a second control terminal; 23. a first developing section; 30. a second developing wire; 31. a third control terminal; 32. a fourth control terminal; 33. a second developing section; 50. controlling the filament; 51. and an operation end. .

Detailed Description

Experimental procedures according to the invention, in which no particular conditions are specified in the following examples, are generally carried out under conventional conditions, or under conditions recommended by the manufacturer. The various chemicals used in the examples are commercially available.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, apparatus, article, or device that comprises a list of steps is not limited to only those steps or modules listed, but may alternatively include other steps not listed or inherent to such process, method, article, or device.

The "plurality" referred to in the present invention means two or more. "and/or" describes the association relationship of the associated objects, meaning that there may be three relationships, e.g., a and/or B, which may mean: a exists alone, A and B exist simultaneously, and B exists alone. The character "/" generally indicates that the former and latter associated objects are in an "or" relationship.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; when an element is referred to as being "mounted on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.

As used herein, unless otherwise specified or defined, the terms "comprises," "comprising," and "comprising" are used interchangeably to refer to the term "comprising," and are used interchangeably herein.

It is needless to say that technical contents or technical features which are contrary to the object of the present invention or clearly contradicted by the object of the present invention should be excluded.

As shown in fig. 1 and 2, the present invention provides a developing filament 20, which includes a filament main body, and a first control end 21, a second control end 22 and a first developing section 23, which are disposed on the filament main body and used for taking and placing the filament main body, wherein the first control end 21 and the second control end 22 are respectively located at two ends of the first developing section 23;

Compared with the traditional metal developing wire, the developing wire prepared by adopting the high-molecular wire or the hydrogel wire has lower elastic modulus, is more favorable for the developing wire to be wound and fixed on the stopper, and simultaneously avoids the developing wire possibly damaging tissues in the withdrawing process caused by the high elastic modulus, thereby being favorable for protecting human tissues.

Preferably, the polymer wire with the lubricating layer on the surface is prepared by the following steps:

(3) then, solidifying the wire obtained in the step (2);

wherein a developing material is introduced in step (1) or (2);

the polymer wire is at least one of a polypropylene wire, a polytetrafluoroethylene wire and a polyamide wire; the double-bond polymerizable precursor is at least one of a methacrylamide compound, a methacrylate compound, acrylate, an acrylamide compound, acryloyl chloride and methacrylic anhydride, and preferably the methacrylamide compound is N- (3-aminopropyl) methacrylamide hydrochloride; the double-bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfoacrylic acid.

Wherein, the double bond polymerizable precursor is tightly loaded on the surface of the high-molecular wire material to introduce the double bond, and the mechanical property of the wire material body is not damaged; meanwhile, the coated double-bond polymerizable monomer of a specific kind can form a cross-linked network with a lubricating effect under the action of an initiator, so that a good lubricating effect is realized, double bonds introduced into the polymer wire can further participate in the copolymerization of the double-bond polymerizable monomer, and the bonding force between the cross-linked network with the lubricating effect and the polymer wire is enhanced.

Further, the polymer wire with the surface loaded with the developing material and the lubricating material is prepared by the following steps:

(3) Then, solidifying the wire obtained in the step (2);

preferably, the concentration of the double bond polymerizable monomer in the aqueous solution containing the double bond polymerizable monomer and the initiator is 0.2 wt% to 50 wt%, preferably 1 wt% to 20 wt%, more preferably 5 wt% to 15 wt%, and the concentration of the initiator is 0.05 wt% to 2 wt%, preferably 0.05 wt% to 1 wt%, more preferably 0.05 wt% to 0.5 wt%, and further preferably 0.05 wt% to 0.2 wt%.

Preferably, the initiator is a photoinitiator, further Irgacure 2959.

Preferably, the curing method in step (3) is photocuring.

Preferably, in the step (1), the loading of the double bond polymerizable precursor on the surface of the polymer wire stock comprises a method A or a method B:

the method A comprises the following steps: under the alkaline or neutral condition, coating crosslinkable functional group molecules on the surface of the high-molecular wire, and then coating a double-bond polymerizable precursor, or mixing the crosslinkable functional group molecules and the double-bond polymerizable precursor and then coating; wherein the crosslinkable functional group molecule is a tea polyphenol compound, preferably the tea polyphenol compound is at least one of tannic acid, epigallocatechin gallate and dopamine;

The method A comprises the steps of coating specific types of crosslinkable photon energy molecules on the surface of a polymer wire and then coating a double-bond polymerizable precursor. The crosslinkable optical energy group molecules coated with specific types have strong adhesiveness with the polymer wire, and can be tightly combined on the surface of the polymer wire, so that the introduction of double bonds or developing materials is realized. Particularly, under the alkaline condition, the crosslinkable optical energy group molecules can further undergo self-polymerization, so that the crosslinkable optical energy group molecules can be better adhered to the polymer wire. Meanwhile, the crosslinkable optical energy group molecule of the specific kind has an active reaction functional group which can react with a double-bond polymerizable precursor, and the double bond is introduced by connecting the double-bond polymerizable precursor and the double-bond polymerizable precursor through covalent bonds so as to tightly fix the double bond on the surface of the polymer wire.

Alternatively, the developing material may be introduced in step (1) or (2), or may be introduced simultaneously in step (1) or (2). Further, upon introducing the developing material in step (1), the developing material may be mixed with the crosslinkable functional group molecules; when the developing material is introduced in step (2), the developing material may be mixed with an initiator.

Further, the method A comprises the following steps: and (3) immersing the high-molecular wire into an aqueous solution containing crosslinkable functional group molecules, adjusting the pH to 7-10, taking out the wire after immersing for 4-8 hours, cleaning, immersing into an aqueous solution containing the double-bond polymerizable precursor, and taking out the wire after immersing for 4-8 hours.

Alternatively, the polymer wire in the method A can be subjected to plasma treatment and then immersed into the aqueous solution containing the crosslinkable functional group molecules.

Further, the method B comprises the following steps: and (3) carrying out plasma treatment (hydroxyl introduction) on the surface of the polymer wire, soaking the polymer wire in an ether solution of triethylamine, adding the double-bond polymerizable precursor at 0-4 ℃, reacting for 20-30 hours at room temperature, and taking out the wire.

Preferably, the concentration of the crosslinkable functional group molecules in the crosslinkable functional group molecule-containing aqueous solution is 1-10 mg/mL, preferably 3-7 mg/mL, more preferably 4-6 mg/mL, and further 5 mg/mL; the concentration of the double-bond polymerizable precursor in the aqueous solution is 0.5-10 mg/mL, preferably 0.5-5 mg/mL, more preferably 0.5-2 mg/mL, and more preferably 0.8-1.5 mg/mL.

Preferably, the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium, and rhodium. Further, the developing material is developing nanoparticles, and further the developing material is at least one of tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles, and rhodium nanoparticles.

Preferably, the base is at least one of sodium hydroxide and triethylamine.

Preferably, the coating is by dip coating or wiping or spraying.

Preferably, the developing material-supporting hydrogel thread is prepared by a process comprising the steps of:

dispersing the developing material in a mixed solution of crosslinkable functional group molecules and alkali to obtain the developing material modified by the crosslinkable functional group molecules;

wherein the gel precursor is polyvinyl alcohol; the crosslinkable functional group molecule is at least one of tannic acid, epigallocatechin gallate and dopamine.

The developing material is modified by crosslinkable functional group molecules, the dispersibility of the developing material in a gel precursor aqueous solution is better, and the crosslinkable functional group molecules on the developing material are beneficial to increasing the hydrogen bond effect of the surface of the developing material and the gel precursor to form a developing material crosslinked hydrogel network, wherein the developing material (especially developing nanoparticles) has a developing function and further enhances the mechanical strength of a hydrogel developing line.

Preferably, in the mixed solution of the crosslinkable functional group molecules and the base in the step (one), the concentration of the crosslinkable functional group molecules is 5-15 mg/mL, and more preferably 10 mg/mL.

Preferably, the concentration of the gel precursor in the aqueous gel precursor solution is 20 to 40 wt%, more preferably 25 to 35 wt%, and still more preferably 30 wt%.

Preferably, the concentration of the developing material in the gel precursor aqueous solution is 5 to 20mg/mL, more preferably 5 to 15mg/mL, and more preferably 10 mg/mL.

Preferably, the die is a cylindrical die, and the diameter of the cylindrical die is 0.1-0.3 mm, and more preferably 0.2 mm.

The present invention will be described in further detail with reference to specific examples.

As shown in fig. 1 and 2, the embodiment further provides a developing-function plugging device, which includes a supporting body 10 and a developing wire 20, wherein the developing wire is the developing wire.

Specifically, the plugging device is including the support main part 10 and the first developing silk 20 that are network structure, first developing silk 20 can dismantle set up in support main part 10 is last, first developing silk 20 includes first control end 21, second control end 22 and first development section 23, first control end 21 and second control end 22 are located the both ends of first development section 23 respectively, first development section 23 is located in support main part 10, be equipped with first end 11 on the support main part 10, first control end 21 and second control end 22 all stretch out from first end 11.

The developing wire is detachably arranged on the supporting main body 10 with the net structure, so that the developing wire can be fixed on the supporting main body 10 in the process of putting the occluder into a human body, the occluder can develop under X-ray, and a doctor can conveniently convey and release the occluder; meanwhile, the developing section is positioned in the supporting main body 10, the developing range can be expanded, compared with the method that only a small amount of parts of the occluder are marked in the past, the whole developing section is more beneficial to evaluating the release form of the occluder, and the operation difficulty and the operation risk are reduced; after the stopper is released, the developing wire is detached from the stopper and is withdrawn from the human body by pulling and controlling the first control end 21 or the second control end 22, so that foreign body reaction caused by residual developing marks in the human body is avoided, and discomfort to the human body is avoided; the first control end 21 and the second control end 22 extend out from the first end 11 of the support main body 10, so that the developing wire can be pulled and controlled to withdraw from a human body, and meanwhile, the developing wire can be prevented from falling off from the occluder.

As shown in fig. 1 and 2, the supporting body 10 includes a first tray body, a second tray body and a connecting waist body, the connecting waist body is located between the first tray body and the second tray body and forms an i-shaped supporting body 10, the first end portion 11 is located on the first tray body, the supporting body 10 is further provided with a first winding portion 13, a second winding portion 14, a third winding portion 15, a fourth winding portion 16 and a second end portion 12, the first winding portion 13 is located between the first tray body and the connecting waist body, the second winding portion 14 is located between the second tray body and the connecting waist body, the third winding portion 15 is symmetrically arranged with the first winding portion 13 along a central axis of the supporting body 10, the fourth winding portion 16 is also symmetrically arranged with the second winding portion 14 along the central axis of the supporting body 10, the second end portion 12 is located on the second tray body, the second end portion 12 is arranged corresponding to the first end portion 11, wherein the first end 11 is a proximal end of the support body 10 and the second end 12 is a distal end of the support body 10. Because the position with the highest bending deformation degree on the plugging device is arranged between the disk body and the waist connecting body, the winding part is arranged between the disk body and the waist connecting body, so that the developing wire can be more attached to the outline of the supporting main body 10, and the developing effect is improved; meanwhile, the plurality of penetrating and winding parts are arranged, so that the developing wire is not easy to loosen from the occluder in the process of sending the occluder into a human body, and normal development and smooth putting of the occluder are guaranteed.

The following are embodiments of the detachable arrangement of the first developing wire 20 in the above-described support main body 10:

the first developing wire 20 extends from the mesh of the first end portion 11 of the support body 10 toward the side close to the second end portion 12, extends to the first winding portion 13, winds the mesh of the first winding portion 13, extends to the second winding portion 14, winds the mesh of the second winding portion 15, extends to the second end portion 12, winds the mesh of the second end portion 12, extends back toward the side close to the first end portion 11, extends to the third winding portion 15, winds the mesh of the third winding portion 15, extends to the fourth winding portion 16, winds the mesh of the fourth winding portion 16, extends back to the first end portion 11, and extends from the first end portion 11. The first developing wire 20 is detachably arranged on the supporting main body 10 in the above penetrating and weaving manner, so that the developing range of the first developing wire 20 in the occluder is expanded, the outline of the whole occluder can be developed roughly, the problem of incomplete developing caused by the fact that the developing marks are only located at individual parts of the occluder in the prior art is solved, the releasing position of the occluder can be adjusted, the releasing state of the occluder can be grasped, the operation difficulty of a doctor is reduced, and the operation risk of a patient is reduced. It should be noted that the above weaving method of passing and winding the developing wire is only one of the preferred embodiments, and it is possible to realize rapid passing and winding and to realize development of the basic outline of the occluder, but it is possible to position different passing and winding portions on the support main body 10 according to the development requirement of the occluder, and to realize different passing and winding methods.

In order to further improve the developing effect of the stopper, a second developing wire 30 is additionally arranged, the second developing wire 30 comprises a third control end 31, a fourth control end 32 and a second developing section 33, the third control end 31 and the fourth control end 32 are respectively located at two ends of the second developing section 33, and the third control end 31 and the fourth control end 32 both extend out from the first end portion 11 of the supporting main body 10. The second developing wire 30 has the same structure as the first developing wire 20, and the third control end 31 and the fourth control end 32 extend from the first end 11 of the supporting main body 10, so as to facilitate pulling control of the second developing wire 30 to withdraw from the human body, and simultaneously prevent the second developing wire 30 from falling off from the occluder.

The first developing wire 20 is arranged on the supporting main body 10 in the winding manner and forms a first plane, the second developing wire 30 is wound in the winding manner according to the similar steps, the second developing wire 30 is detachably arranged on the supporting main body 10 and forms a second plane, but different from the winding manner, the second plane formed by winding the second developing wire 30 in the winding manner and the first plane formed by winding the first developing wire 20 form an included angle of 90 degrees. Because the occluder is a three-dimensional device, the second plane and the first plane are arranged at an included angle of 90 degrees, the overall outline of the occluder can be more comprehensively displayed, the developing effect is improved, and the situation that the displacement of the occluder in the process of being implanted into a human body affects the developing angle of the first developing wire 20 is avoided. However, it should be noted that the number of the developing wires and the degree of the included angle formed by the winding can be adjusted according to the actual situation.

The above-mentioned manner of withdrawing from the human body by pulling the control end of the developing wire is a preferred embodiment of the present invention, as shown in fig. 3, in one embodiment, the present invention further includes a separately disposed control wire 50, the control wire 50 is disposed outside the supporting body 10, the control wire 50 is connected to the position where the developing wire is threaded around the second end 12 of the supporting body 10, the end of the control wire 50 away from the end connected to the developing wire is an operation end 51, wherein the operation end 51 extends outside the human body, and in order to prevent the control wire 50 from affecting the smooth threading of the developing wire on the stopper, the control wire 50 can be connected to the developing wire after the completion of the disposing of the developing wire. After the release of the occluder is finished, the two ends of the developing wire 50 are simultaneously pulled out from the second end part 12 by pulling the operation end 51 of the control wire 50, so that the speed of detaching the developing wire from the occluder and withdrawing the developing wire from a human body is increased, and the working efficiency is improved.

The material of the support main body 10 is degradable material, and the degradable material is at least one material of polylactic acid, polyglycolic acid, polycaprolactone, polyanhydride and polydioxanone. The occluder made of degradable materials can avoid complications such as valve injury, atrioventricular block, heart tissue abrasion, thrombus and the like caused by residual body, is more favorable for recovering the operation and avoids adverse effects on the subsequent life of a patient.

The occluder is further provided with a flow resisting film (not shown in the figure), the flow resisting film is respectively sewn on the first disk body, the second disk body and the waist connecting body, and the flow resisting film is provided with a plurality of layers. The flow-resistant film can be prepared from degradable high polymer materials such as polylactic acid and the like. The flow-resistant membrane is sewn on the occluder, which is beneficial to promoting the growth of endothelium, so that the endothelium is easier to climb and the rehabilitation speed of patients is increased.

Material sources are as follows:

polyvinyl alcohol: 1799 type, weight average molecular weight 90000.

Polyethylene glycol diacrylate: purchased from TCI, molecular weight 258.

EXAMPLE 1 preparation of a Blockable device containing a developer wire

The method is characterized in that a poly-p-dicyclohexyl ketone wire is adopted to weave an I-shaped occluder framework, then a developing wire is arranged from the near end of the occluder, penetrates through a gap in the framework along the axial direction of the framework, reaches the far end vertex of the occluder, then starts to penetrate through the gap towards the near end, returns to the near end vertex, the path of the developing wire is symmetrically distributed along the central axis of the occluder, and finally the end of the developing wire is exposed outside the body along a conveying system. According to a similar procedure, a second developing wire is threaded on the framework along the axial direction of the framework and in a direction forming an angle of 90 degrees with the direction of the first developing wire, and the end of the developing wire is exposed outside the body along the conveying system. In the implantation process of the occluder, the developing wire is positioned on the whole outline of the occluder framework, so that the whole occluder can be developed, the problem that the developing marks are only positioned at individual parts of the occluder and are not completely developed in the prior art is solved, the release position of the occluder is better adjusted, and the release state of the occluder is better mastered. Meanwhile, the developing wire on the occluder can be separated from the occluder and withdrawn by controlling the end head in vitro, so that the residue of the developing substance in vivo is avoided.

EXAMPLE 2 hydrogel-coated Polypropylene developer filaments

(1) Preparation of hyaluronic acid methacrylate: hyaluronic acid was dissolved in an aqueous solution (0.1 wt%), passed through a cation exchange resin, and then lyophilized. Then dissolving in DMSO solution, adding methacrylic acid anhydride corresponding to 0.2 equivalent (mass ratio) of hyaluronic acid, reacting for 24 hr, adding chloroform into the reaction solution for precipitation, dissolving the precipitate in water, dialyzing in dialysis bag, and lyophilizing to obtain hyaluronic acid methacrylate.

(2) The polypropylene wire is firstly soaked in a mixed aqueous solution of 5mg/mL tannic acid and 1mg/mL tungsten nanoparticles, 1M sodium hydroxide is added to adjust the pH value to 9, the polypropylene wire is soaked for 6 hours, taken out, washed with deionized water for three times, and then soaked in an aqueous solution (1mg/mL) of N- (3-aminopropyl) methacrylamide hydrochloride (pH 8) for 6 hours. And taking out the polypropylene wire, and washing with deionized water for three times to obtain the polypropylene wire with surface modified double bonds and developing nanoparticles. The double bonds and the developing nano particles can be simultaneously introduced into the surfaces of various wires through simple steps without damaging the mechanical property of the wire body, wherein the developing nano particles have larger surface area, the introduction amount of the double bonds can be further increased, the developing function is realized simultaneously, and the method does not need to carry out pretreatment on the wires.

(3) And (3) soaking the polypropylene wire with the surface modified double bonds and the developed nano particles obtained in the step (2) in 0.5 wt% of hyaluronic acid methacrylate and 0.1 wt% of Irgacure 2959 aqueous solution of a photoinitiator for 10 minutes, and taking out to carry out curing under ultraviolet light. The hyaluronic acid methacrylate in the step can form a cross-linked network under the polymerization action of an initiator so as to play a lubricating role, and double bonds on the surface of the polypropylene wire can participate in the copolymerization of the double bonds in the hyaluronic acid methacrylate, so that the binding force between the hyaluronic acid network and the polypropylene wire is enhanced.

EXAMPLE 3 hydrogel-coated Polypropylene developer filaments

(1) Preparing polyvinyl alcohol acrylate: 5.0g of polyvinyl alcohol (PVA) was dissolved in 100ml of dimethyl sulfoxide (DMSO). Dimethylaminopyridine and glycidyl acrylate were added in amounts of 1.0 mol% (relative to the hydroxyl groups of the PVA) and 0.025 mol% (relative to the hydroxyl groups of the PVA), respectively. Stirring at 60 deg.C for 6h, adding acetone into the reaction solution for precipitation, vacuum drying the precipitate for 2 days, and storing at-5 deg.C in dark place.

(2) The polypropylene wire is firstly soaked in a mixed aqueous solution of 5mg/mL tannic acid and 1mg/mL tantalum nanoparticles, 1M sodium hydroxide is added to adjust the pH value to 9, the polypropylene wire is soaked for 6 hours, taken out, washed with deionized water for three times, and then soaked in an aqueous solution (1mg/mL) of N- (3-aminopropyl) methacrylamide hydrochloride (pH 8) for 6 hours. And taking out the polypropylene wire, and washing with deionized water for three times to obtain the polypropylene wire with surface modified double bonds and developing nanoparticles. The double bonds and the developing nanoparticles can be simultaneously introduced into the surface of the polypropylene wire through simple steps, and the mechanical property of the wire body is not damaged. The developing nano particles can further increase the introduction amount of double bonds and simultaneously realize the developing function, and the method does not need to carry out pretreatment on the silk materials.

(3) And (3) soaking the polypropylene wire with the surface modified double bonds and the developed nano particles obtained in the step (2) in 1 wt% of polyvinyl alcohol acrylate and 0.1 wt% of Irgacure 2959 aqueous solution of a photoinitiator for 10 minutes, and taking out to carry out curing under ultraviolet light. The polyvinyl alcohol acrylate in the step can be polymerized under the action of an initiator to form a cross-linked network, so that the lubrication effect is achieved, and the double bonds on the surface of the polypropylene wire can participate in the copolymerization of the double bonds in the polyvinyl alcohol acrylate, so that the binding force between the polyvinyl alcohol hydrogel network and the polypropylene wire is enhanced.

EXAMPLE 4 Polymer coated Polytetrafluoroethylene developing wire

(1) The polytetrafluoroethylene filament was first immersed in an aqueous solution of 5mg/mL epigallocatechin gallate and 1mg/mL barium sulfate nanoparticles, 1M sodium hydroxide was added to adjust the pH to 9, the filament was immersed for 6 hours, the polypropylene filament was taken out, washed three times with deionized water, and then immersed in an aqueous solution of N- (3-aminopropyl) methacrylamide hydrochloride (1mg/mL) (pH 8) for 6 hours. And taking out the polypropylene wire, and washing with deionized water for three times to obtain the polytetrafluoroethylene wire with surface modified double bonds and developing nanoparticles. The double bonds and the developing nanoparticles can be simultaneously introduced into the surface of the polytetrafluoroethylene wire through simple steps, and the mechanical property of the wire body is not damaged.

(2) And (3) soaking the polytetrafluoroethylene wire with the surface modified double bonds and the developed nanoparticles obtained in the step (2) in 10 wt% of vinyl pyrrolidone and 0.1 wt% of Irgacure 2959 aqueous solution of a photoinitiator for 10 minutes, and taking out to carry out curing under ultraviolet light. The vinyl pyrrolidone monomer in the step can be polymerized under the action of an initiator to form the polyvinyl pyrrolidone, so that the hydrophilic effect and the lubricating property are good, the double bonds on the surface of the wire material participate in the polymerization of the vinyl pyrrolidone, the bonding force with the substrate is enhanced, the polyvinyl pyrrolidone and the lower double bond epigallocatechin gallate can generate the hydrogen bonding effect, and the bonding force with the substrate is further enhanced.

EXAMPLE 5 Polymer coated Polytetrafluoroethylene developing wire

(1) The polytetrafluoroethylene filament is firstly soaked in an aqueous solution of 5mg/mL dopamine and 1mg/mL barium sulfate nanoparticles, 1M sodium hydroxide is added to adjust the pH value to 8.5, the polypropylene filament is soaked for 6 hours, taken out, washed with deionized water for three times, and then soaked in an aqueous solution (pH value is 8) of N- (3-aminopropyl) methacrylamide hydrochloride (1mg/mL) for 6 hours. Taking out the polytetrafluoroethylene wire, and washing with deionized water for three times to obtain the polytetrafluoroethylene wire with surface modified double bonds and developing nanoparticles. The double bonds and the developing nanoparticles can be simultaneously introduced into the surface of the polytetrafluoroethylene wire through simple steps, and the mechanical property of the wire body is not damaged.

(2) And (3) soaking the polytetrafluoroethylene wire with the surface modified double bonds and the developed nanoparticles obtained in the step (2) in aqueous solution of 10 wt% of sulfobetaine methacrylate and 0.1 wt% of photoinitiator Irgacure 2959 for 10 minutes, and taking out to carry out curing under ultraviolet light. The sulfobetaine methacrylate monomer in the step can be polymerized under the action of an initiator to form the zwitterion hydrogel, so that the zwitterion hydrogel has good hydrophilic effect, lubricity and anticoagulation performance, and double bonds on the surface of the wire participate in the polymerization of the hydrogel, so that the binding force between the hydrogel and a substrate is enhanced.

EXAMPLE 6 hydrogel-coated Polytetrafluoroethylene developing filament

(1) The polytetrafluoroethylene wire is firstly subjected to plasma surface treatment, soaked in an aqueous solution of 5mg/mL dopamine and 1mg/mL barium sulfate nanoparticles, added with 1M sodium hydroxide to adjust the pH value to 8.5, soaked for 6 hours, taken out of the polypropylene wire, washed with deionized water for three times, and then soaked in an aqueous solution (pH value is 8) of N- (3-aminopropyl) methacrylamide hydrochloride (1mg/mL) for 6 hours. Taking out the polytetrafluoroethylene wire, and washing the polytetrafluoroethylene wire with deionized water for three times, the double bonds and the developing nanoparticles can be simultaneously introduced into the surface of the polytetrafluoroethylene wire through simple steps, and the mechanical property of the wire body is not damaged.

(2) Soaking in 10 wt% sulfonic acid acrylic acid, 0.5 wt% polyglycol diacrylate and 0.1 wt% Irgacure 2959 water solution as photoinitiator for 10 min, and curing under ultraviolet light. The sulfonic acid acrylic acid monomer and the polyethylene glycol diacrylate in the step can be polymerized under the action of an initiator to form the anionic hydrogel, so that the anionic hydrogel has good hydrophilic effect, lubricity and anticoagulation performance, and meanwhile, the double bonds on the surface of the silk material participate in the polymerization of the hydrogel, so that the binding force between the hydrogel and a substrate is enhanced.

EXAMPLE 7 hydrogel-coated Polyamide developer filaments

(1) Firstly, carrying out plasma treatment on the surface of a polyamide wire to introduce hydroxyl, then soaking the polyamide wire in an ether solution containing 8 wt% of triethylamine in volume fraction, adding acryloyl chloride accounting for 10% of the triethylamine in volume fraction at zero temperature, reacting at room temperature for 24 hours, taking out the polypropylene wire, and washing the polypropylene wire with deionized water for three times.

(2) And (2) soaking the polypropylene wire with the surface modified double bonds and the developed nano particles obtained in the step (1) in 1 wt% of hyaluronic acid methacrylate aqueous solution, 1mg/mL of bismuth nano particle aqueous solution and 0.1 wt% of photoinitiator Irgacure 2959 aqueous solution for 10 minutes, and taking out to carry out curing under ultraviolet light. The hyaluronic acid methacrylate in the step can be polymerized under the action of an initiator to form hydrogel, and the developing nano particles are wrapped in the hydrogel, so that the hyaluronic acid methacrylate has good lubricity and developing performance, and double bonds on the surface of the wire participate in the polymerization of the hydrogel, so that the binding force between the hydrogel and a substrate is enhanced.

EXAMPLE 8 hydrogel development Silk

Ultrasonically dispersing 0.01g of tantalum nanoparticles into 10mL of 10mg/mL tannic acid aqueous solution, adding sodium hydroxide solution to adjust the pH value to 9, reacting for 6 hours, and centrifuging the solution to obtain the tannic acid modified tantalum nanoparticles. And adding the obtained tannin modified tantalum nanoparticles into 30 wt% polyvinyl alcohol aqueous solution for dispersion, wherein the final concentration is 10mg/mL, injecting the obtained solution into a cylinder mold with the diameter of 0.2mm, putting the cylinder mold into a cylinder mold for freezing at-20 ℃ for 24h, taking out the cylinder mold for dissolution, and repeatedly freezing and thawing for three times to obtain the nanoparticle enhanced hydrogel development line. In the developing line obtained by the technology, the nanoparticles are subjected to surface modification by the tannic acid, so that the dispersibility in the polyvinyl alcohol solution is better, meanwhile, the tannic acid on the nanoparticles is beneficial to increasing the hydrogen bond effect of the nanoparticles on the polyvinyl alcohol, and a nanoparticle cross-linked hydrogel network is formed, wherein the nanoparticles are introduced to have a developing function, and the mechanical strength of the hydrogel developing line is further enhanced.

Comparative example 1

A developing wire is prepared in the following way: soaking polypropylene wire material in mixed water solution of 5mg/mL tannic acid and 1mg/mL tungsten nano particle, adding 1M sodium hydroxide to regulate pH to 9, soaking for 6 hr, taking out the polypropylene wire material, and washing with deionized water for three times.

Comparative example 2

A developing wire is a polypropylene wire without treatment.

Comparative example 3

A developing wire is a nickel-titanium alloy wire with a diameter of 0.2 mm.

Withdrawal force and modulus of elasticity test

The developing wires of examples 2 to 8 and comparative examples 1 to 3 were wound into the same stopper in the manner described in example 1, and after the stopper was released from conveyance, one end of the developing material was fixed by a tensile machine, the developing wire was withdrawn, and the withdrawal force thereof was tested. As seen from the results of table 1 below, the developing wires of examples 2 to 8 of the present invention have low withdrawal force and elastic modulus. The coating on the surface of the polymer wire does not obviously influence the modulus of the polymer wire, and the withdrawal force of the developing wire is obviously reduced after monomer polymerization is carried out on the surface.

TABLE 1

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A developing wire is characterized by comprising a wire main body, a first control end and a second control end, wherein the first control end and the second control end are arranged on the wire main body and used for taking and putting the wire main body;

the developing wire is made of a high-polymer wire material of which the surface is provided with a lubricating layer, and the lubricating layer is loaded with a developing material; or the developing silk is a hydrogel line loaded with a developing material;

the polymer wire with the lubricating layer on the surface is prepared by the following steps:

(3) then, solidifying the wire obtained in the step (2);

wherein a developing material is introduced in step (1) or (2);

the polymer wire is at least one of a polypropylene wire, a polytetrafluoroethylene wire and a polyamide wire;

the double-bond polymerizable precursor is at least one of a methacrylamide compound, a methacrylate compound, acrylic ester, an acrylamide compound, acryloyl chloride and methacrylic anhydride,

the double-bond polymerizable monomer is at least one of hyaluronic acid methacrylate, polyvinyl alcohol acrylate, polyethylene glycol diacrylate, vinyl pyrrolidone, sulfobetaine methacrylate and sulfoacrylic acid;

the developing material-supporting hydrogel thread is prepared by the following steps:

wherein the gel precursor is polyvinyl alcohol; the crosslinkable functional group molecule is a tea polyphenol compound.

2. The developing wire according to claim 1, wherein the polymer wire having the lubricating layer on the surface thereof is prepared by the steps of:

(2) soaking the wire obtained in the step (1) in an aqueous solution containing a double-bond polymerizable monomer and an initiator for 5-15 minutes;

(3) then, solidifying the wire obtained in the step (2);

the concentration of the double-bond polymerizable monomer in the aqueous solution containing the double-bond polymerizable monomer and the initiator is 0.2-50 wt%, and the concentration of the initiator is 0.05-2 wt%.

3. The developing wire according to claim 1, wherein the step (1) of loading the double bond polymerizable precursor on the surface of the polymer wire stock comprises a method A or a method B:

the method A comprises the following steps: under the alkaline or neutral condition, coating crosslinkable functional group molecules on the surface of the high-molecular wire, and then coating a double-bond polymerizable precursor, or mixing the crosslinkable functional group molecules and the double-bond polymerizable precursor and then coating;

in the method A, the crosslinkable functional group molecules are tea polyphenol compounds;

the method B comprises the following steps: plasma treatment is carried out on the surface of the polymer wire, and a double-bond polymerizable precursor is coated.

4. The developing wire according to claim 3, wherein the method A comprises the following steps: soaking a high-molecular wire into an aqueous solution containing crosslinkable functional group molecules, adjusting the pH to 7-10, taking out the wire after soaking for 4-8 hours, washing, soaking into an aqueous solution containing the double-bond polymerizable precursor, and taking out the wire after soaking for 4-8 hours;

or, the method B comprises the following steps: and (3) introducing hydroxyl plasma treatment on the surface of the polymer wire, soaking the polymer wire in an ether solution of triethylamine, adding the double-bond polymerizable precursor at 0-4 ℃, reacting for 20-30 hours at room temperature, and taking out the wire.

5. The developing wire according to claim 4, wherein the concentration of the crosslinkable functional group molecules in the aqueous solution containing the crosslinkable functional group molecules is 1 to 10 mg/mL; the concentration of the double-bond polymerizable precursor in the aqueous solution is 0.5-10 mg/mL.

6. The developer wire according to any one of claims 1 to 5, wherein the initiator is a photoinitiator;

and/or, the curing method in the step (3) is photocuring;

and/or the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium and rhodium; and/or the coating mode is dip coating or wiping coating or spraying coating.

7. The developing wire of claim 6, wherein the initiator is Irgacure 2959.

8. The developing filament according to claim 1, wherein the crosslinkable functional group molecule in the developing material-supporting hydrogel line is at least one of tannic acid, epigallocatechin gallate and dopamine.

9. The developing wire according to claim 8, wherein the concentration of the crosslinkable functional group molecules in the aqueous solution of the crosslinkable functional group molecules of the step (one) is 5 to 15 mg/mL;

and/or the concentration of the gel precursor in the gel precursor aqueous solution is 20-40 wt%, and the concentration of the developing material in the gel precursor aqueous solution is 0.1-20 mg/mL;

and/or the mould is a cylindrical mould, and the diameter of the cylindrical mould is 0.1-0.3 mm;

and/or the developing material is at least one of tungsten, tantalum, barium sulfate, bismuth, gold, platinum, osmium, rhenium, iridium and rhodium.

10. The developer wire according to claim 9, wherein the developer material is at least one of tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles, rhodium nanoparticles.

11. The developing yarn according to claim 1, wherein the methacrylamide compound is N- (3-aminopropyl) methacrylamide hydrochloride.

12. The developing filament according to claim 3, wherein the tea polyphenol compound is at least one of tannic acid, epigallocatechin gallate and dopamine.

13. The developer wire according to claim 6, wherein the developer material is at least one of tungsten nanoparticles, tantalum nanoparticles, barium sulfate nanoparticles, bismuth nanoparticles, gold nanoparticles, platinum nanoparticles, osmium nanoparticles, rhenium nanoparticles, iridium nanoparticles, rhodium nanoparticles.

14. A stopper with a developing function, which is characterized by comprising a supporting main body and a developing wire, wherein the developing wire is the developing wire according to any one of claims 1 to 13.