WO2022203684A1 - Aliments pour favoriser une meilleure santé et/ou pour maintenir l'homéostasie et leur procédé de production - Google Patents

Aliments pour favoriser une meilleure santé et/ou pour maintenir l'homéostasie et leur procédé de production Download PDF

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WO2022203684A1
WO2022203684A1 PCT/US2021/024433 US2021024433W WO2022203684A1 WO 2022203684 A1 WO2022203684 A1 WO 2022203684A1 US 2021024433 W US2021024433 W US 2021024433W WO 2022203684 A1 WO2022203684 A1 WO 2022203684A1
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product
isotopes
livestock
chemical elements
food
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PCT/US2021/024433
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WO2022203684A8 (fr
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Peter Y. Novak
Maxim V. Temnikov
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Vector Vitale Ip Llc
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Priority to CA3212869A priority Critical patent/CA3212869A1/fr
Priority to AU2021436233A priority patent/AU2021436233A1/en
Priority to EP21719802.7A priority patent/EP4312583A1/fr
Priority to PCT/US2021/024433 priority patent/WO2022203684A1/fr
Priority to JP2023558864A priority patent/JP2024513176A/ja
Publication of WO2022203684A1 publication Critical patent/WO2022203684A1/fr
Publication of WO2022203684A8 publication Critical patent/WO2022203684A8/fr

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    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05D—INORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C; FERTILISERS PRODUCING CARBON DIOXIDE
    • C05D9/00—Other inorganic fertilisers
    • C05D9/02—Other inorganic fertilisers containing trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F17/00—Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation
    • C05F17/10—Addition or removal of substances other than water or air to or from the material during the treatment
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F9/00—Fertilisers from household or town refuse
    • C05F9/04—Biological compost
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G1/00—Mixtures of fertilisers belonging individually to different subclasses of C05

Definitions

  • This disclosure relates to engineered food for promoting better health and/or maintaining homeostasis in a subject.
  • Vaccines are virus or bacteria specific and thus are not equipped to protect humans from new infections and even from modified old ones. Mankind has to deal with new and possibly more dangerous infectious agents continuously. Degenerative diseases, such as Parkinson’s, Alzheimer’s, etc., are major health problems to humans, and are without cure. Maintaining homeostasis and/or promoting health in a subject must be a priority.
  • this disclosure provides a method of producing a food product from a plant comprising growing the plant in fertilizer or compost comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or foliar feeding the plant a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or growing the plant in hydroponics in a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • this disclosure provides a method of producing a livestock or a livestock product comprising raising the livestock by feeding the livestock food enriched for lightest stable isotope or isotopes thereof or a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or raising the livestock by injecting the livestock intravenously a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • this disclosure provides a method of producing an aquaculture product or a mariculture product comprising raising the aquaculture product or the mariculture product by feeding the aquaculture product or the mariculture product food or solution comprising essential chemical enriched for lightest stable isotope or isotopes thereof.
  • this disclosure provides a product of a plant, a livestock, a livestock product, an aquaculture product, or a mariculture product comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • this disclosure also provides a product of a plant, a livestock or a livestock product, an aquaculture product or a mariculture product made by a disclosed method.
  • this disclosure provides a fertilizer or a compost comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • This disclosure also provides a method of promoting health or a method of maintaining homeostasis in a subject by feeding the subject one or more food items made from a disclosed product of a plant, food made from a disclosed livestock, food made from a disclosed livestock product, or food made from an aquaculture product or a mariculture product.
  • FIG. 1 is a graph showing cytotoxic/cytostatic action of natural zinc and Zn-64 compounds on HL-60 cells.
  • FIG. 2 is a graph showing cytotoxic/cytostatic action of natural zinc and Zn-64 compounds on Lewis lung carcinoma cells.
  • FIG. 3 is a graph showing treatment with Zn-64 (enrichment 99.2%) Inhibits Growth of L1210 Leukemia in mice.
  • the word “a” or “plurality” before a noun represents one or more of the particular noun.
  • compositions and methods described herein can include any combination of features and/or steps described herein not inconsistent with the objectives of the present disclosure. Numerous modifications and/or adaptations of the compositions and methods described herein will be readily apparent to those skilled in the art without departing from the present subject matter.
  • Protein accounts for approximately 20 percent of a cell’s total weight. Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. Section 1.2 New York: W. H. Freeman; 2000.
  • AH chemical elements coming into the body with food have isotope ratios in accordance with their well-known natural abundance. This exact ratio should be expected to be in the cell’s cytoplasm, in case light isotopes are used in the protein’s production, the isotope ratios in cytoplasm should be shifted in favor of heavy ones, leaving total average values per cell equal to the one of incoming into the cell.
  • Some cells produce proteins/polypeptides “for export,” like hormones, cytokines or signaling molecules or breast milk components, for example.
  • the very ability of the cell machinery to produce biomolecules “for export” depends on the materials delivered into the cell. Deficiency in timely supplies of light isotopes would lead to the enrichment of the cytoplasm with heavy isotopes. And use of these isotopes in protein production and inevitable degradation of the products quality: distortion of helices, tendency to the racemization of amino acids in proteins, their damaged conformation, unfolding and possibly aggregation and loss of function. Therefore, exactly these kinds of cells represent the best place for the onset of pathological changes in tissues and organs, including primary or metastatic cancers.
  • Proteins in the healthy living cell should contain only the lightest isotopes of hydrogen, oxygen, nitrogen, carbon essential chemical elements.
  • Potassium and rubidium whether they bind to proteins or play other roles in a cell’s life, are required to be in the form K-39 and Rb-85 isotopes.
  • Treating and preventing degenerative and infectious diseases require sufficient supply of light isotopes like Zn-64, K-39, Mg-24, K-39, or Fe-54, for example.
  • the use of intravenous injections or oral pills with light isotopes compositions exceeding daily consumption dose by a factor of 2-4 for prophylactics of degenerative and infectious diseases can be extremely helpful.
  • the efficacy of such approach depends on dose and drugs ddiyery time. The problem is that this approach cannot prevent heavy isotopes coming with food.
  • the best solution of this problem is to consume isotope selective foods/agricultural products grown in soil fertilized with light isotopes of essential chemical elements.
  • the lightest stable isotopes of essential chemical elements in therapeutic and preventive compounds with various salts and amino acids or biomolecules as vehicles should be used.
  • the best vehicles are chemical compounds in plant foods. [0026] It does not make sense to grow plants in soil for agricultural products with any currently known medical drugs: vaccines, antibiotics, inhibitors, activators, and even most sophisticated products like CAR-T cells as they simply decompose in the ground.
  • salts and amino acids based compounds enriched with lightest isotopes of essential chemical elements can be used as a new type of nutrients or “fertilizers” in the process of agricultural production of various crops, fruits, and vegetables. They may serve as a part of hydroponic nutrient culture medium to produce sprouts or vegetables or to use fast growing plants with subsequent transformation into a compost enriched with lightest stable isotopes of essential chemical elements. This compost in turn can be used as a main component of the soil to grow plants on. Anti -viral and anti -bacterial action of light isotopes provide additional protection for the plants growing on this soil from bacteria and viruses. Products grown in this manner have unique prophylactic and therapeutic properties. These plants or trees would have the same properties as the Tree of Life. Thus, food becomes our medicine in accordance with the famous Hippocrates expression.
  • Daily consumption of isotope-selective food is the best way for promoting health and/or maintaining youthful homeostasis i.e. stability of human organism with simultaneous prevention from degenerative and infectious diseases.
  • Daily consumption doses for essential chemical elements taken with foods are equal to the therapeutic doses determined during phase 1-2 clinical study in patients with metastatic solid tumors, autoimmune diseases, diabetes 1 and 2, obesity, aphasia, and Parkinson’s disease.
  • this disclosure provides a method of producing a food product of a plant comprising growing the plant in fertilizer or compost comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or foliar feeding the plant a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or growing the plant in hydroponics in a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • a food product of a plant is a vegetable or a fruit.
  • the fertilizer, compost, or solution fed to the plants (in which the plants are grown) comprises 64 Zn e.
  • the fertilizer, compost, or solution fed to the plants (in which the plants are grown) comprises 64 Zn e sulfate, 64 Zn e oxide or 64 Zn e aspartate.
  • 64 Zn e is used herein to refer to 64 Zn-enriched zinc. That is, zinc that is enriched for 64 Zn such that 64 Zn is enriched greater than its usual percentage in zinc in nature.
  • this disclosure provides a method of producing a livestock or a livestock product comprising growing the livestock by feeding the livestock food comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof or a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof; or injecting the livestock intravenously a solution comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • the livestock is injected intravenously a solution comprising an amount corresponding to the known daily consumption amount of said essential chemical elements.
  • the food or solution fed to the livestock comprises 64 Zn e .
  • the food or solution fed to the livestock comprises 64 Zn e sulfate, 64 Zn e oxide or 64 Zn e aspartate.
  • the food or solution fed to the livestock comprises 64 Zn e sulfate, 64 Zn e oxide or 64 Zn e aspartate.
  • this disclosure provides a method of producing an aquaculture product or a mariculture product comprising growing the aquaculture product or a mariculture product by feeding the aquaculture product or the mariculture product food or solution comprising essential chemical enriched for lightest stable isotope or isotopes thereof.
  • the food or solution fed to the aquaculture product or a mariculture product comprises 64 Zn e .
  • the food or solution fed to the aquaculture product or a mariculture product comprises 64 Zn e sulfate, 64 Zn e oxide or 64 Zn e aspartate.
  • the food or solution fed to the aquaculture product or a mariculture product comprises one or more salts, one or more metal oxides or one or more metal chelates with amino acids of said essential chemical elements.
  • the livestock, aquaculture product or mariculture product is fed daily with food containing the lightest stable isotope or isotopes of essential chemical elements.
  • this disclosure provides a product of a plant, a livestock, a livestock product, an aquaculture product, or a mariculture product comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • this disclosure provides a product of a plant made by a disclosed method.
  • this disclosure provides a livestock or a livestock product made by a disclosed method.
  • this disclosure provides an aquaculture product or a mariculture product made by a disclosed method.
  • this disclosure provides fertilizer or compost comprising essential chemical elements enriched for lightest stable isotope or isotopes thereof.
  • the essential chemical elements are enriched for lightest stable isotope or isotopes thereof at higher than 85%, 90%, 95% or 99%.
  • the essential chemical element(s) is(are) one or more of H, C, N, O, Zn, Fe, Mg, Si, Se, Rb, K, and Ca.
  • the enriched stable isotope or isotopes of essential chemical elements is one or more of 39 K, 24 Mg, 64 Zn, 85 Rb, 28 Si, 54 Fe, 40 Ca, 74 Se.
  • the enriched stable isotope or isotopes of essential chemical elements is one or more of 3 ⁇ 4, 12 C, 16 0, 14 N, 39 K, 24 Mg, 64 Zn, 85 Rb, 28 Si, 54 Fe, 92 Mo, 74 Se, 58 M, 70 Ge, 52 Cr, 63 Cu, and 50 V.
  • enriched as referring to an isotope of an essential chemical element that is enriched such that it exists in the composition, formulation, compound, etc. at greater than its abundance normally found in nature.
  • zinc is enriched to be at least 80% 64 Zn e , at least 90% 64 Zn e , at least 95% 64 Zn e , or at least 99% 64 Zn e , for example, zinc that is 80% 64 Zn e , 85% 64 Zn e , 90%
  • the 64 Zn e is in a form of salt selected from the group consisting of aspartate, sulfate, and citrate. In some embodiments, the 64 Zn e is in a form of 64 Zn e aspartate with chemical formula of C4H504N 64 Zn e with 2 aspartic acid molecules.
  • zinc aspartate has a chemical formula - C 4 H 5 0 4 N 64 Zn e , with 2 aspartic acid molecules.
  • the structure of zinc aspartate is:
  • this disclosure provides food made from a disclosed product of a plant, food made from a disclosed livestock, food made from a disclosed livestock product, or food made from an aquaculture product or a mariculture product.
  • this disclosure provides a method of promoting health in a subject by feeding the subject one or more of food made from a disclosed product of a plant, food made from a disclosed livestock, food made from a disclosed livestock product, or food made from an aquaculture product or a mariculture product.
  • the food is cooked before feeding to the subject.
  • this disclosure provides a method of maintaining homeostasis in a subject by feeding the subject one or more of food made from a disclosed product of a plant, food made from a disclosed livestock, food made from a disclosed livestock product, or food made from an aquaculture product or a mariculture product.
  • the food is cooked before feeding to the subject.
  • the disclosed food may be consumed by a subject in any way a food is consumed and processed in any way food for consumption is processed.
  • an agricultural product is a crop, livestock and livestock product, including but not limited to field crop, fruit, vegetable, cattle, sheep, hog, goat, horses, poultry, furbearing animals, milk, and eggs.
  • An agricultural product includes plants and livestock and livestock products.
  • a livestock product includes but is not limited to milk and eggs.
  • food made from a livestock product includes but is not limited to milk, eggs, cream, yogurt, and cheese. Food made from a livestock product includes all dairy products. [0055] As used herein, food made from a livestock includes but is not limited to meat (such as steak, roast, etc.), pate, sausage, cured meats, and deli meats.
  • a product of a plant includes but is not limited to field crop, fruit, and vegetable.
  • food made from a product from a plant includes but is not limited to fruits, vegetables, plant oil, coffee, tea, cereal, grains, rice, pasta, potatoes, fruit or plant juice, beer, wine, wheat, oats, rye, barley, com, triticale, millet, whisky and other alcoholic beverages, other beverages that contain fruit or plant matters, etc.
  • aquaculture broadly refers to the cultivation of freshwater aquatic organisms in controlled aquatic environments for any commercial, recreational or public purpose.
  • breeding, rearing and harvesting of plants and animals takes place in all types of water environments including ponds, rivers, lakes, and man-made “closed” systems on land.
  • Said cultivated freshwater aquatic organisms are “aquaculture products.”
  • food made from aquaculture products includes but is not limited to fish, clams, water mites, snails, eels, etc.
  • the term “mart culture,” or “marine aquaculture” broadly refers to the cultivation of marine aquatic organisms in controlled marine aquatic environments for any commercial, recreational or public purpose. The breeding, rearing and harvesting of plants and animals takes place in all types of water environments including oceans and man-made “closed” systems on land. Said cultivated marine aquatic organisms are “rnariculture products” or “marine aquaculture products.”
  • food made from rnariculture products includes but is not limited to fish, shrimps, crabs, lobsters, clams, mussels, jellyfish, squid, etc.
  • hydroponics refers to a method of growing plants, usually crops, without soil, by using solutions comprising nutrients.
  • foliar feeding refers to a technique of feeding plants by applying a solution comprising liquid fertilizer directly to the leaves of the plants.
  • a “subject” may be an animal subject or a plant subject.
  • An animal subject includes a human subject or a non-human animal subject.
  • the disclosed food may be in any suitable form.
  • the disclosed food may be consumed by first cooking the food or consumed raw.
  • the term “light isotopes” refers to at least the following isotopes: 3 ⁇ 4, 12 C, 40 Ca, 16 0, 14 N, 39 K, 24 Mg, 64 Zn, 85 Rb, 28 Si, 54 Fe, 92 Mo, 74 Se, 58 M, 70 Ge, 52 Cr, 63 Cu, and 50 V.
  • Homeostasis is the state of steady internal, physical, and chemical conditions maintained by living systems. Homeostasis is brought about by a natural resistance to change when already in the optimal conditions, and equilibrium is maintained by many regulatory mechanisms. Homeostasis is any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival. The stability attained is actually a dynamic equilibrium, in which continuous change occurs yet relatively uniform conditions prevail.
  • proteins including antibodies, are made from levorotatory amino acids and have structures with right-handed helices. But What if proteins on the surface of invading bacteria or viruses are unrecognizable to any antibodies produced by B cells? Bacteria or virus presenting proteins made of dextrorotatory amino acids would be invincible to the immune system. It does not matter how many random mutations in the antibody variable region genes will be produced, the most important change will never be possible to achieve - the change of the antibody chirality. Pathogen’s proteins with wrong conformation due to the presence of right- handed amino acids would have significantly distorted helixes. The degree of distortion, which is proportional to the number of D-amino acids in it, may be a useful feature for the pathogen to counter antibodies and to vaccines.
  • proteins of SARS-CoV-2 have wrong conformation and/or partially unfolded, then antibodies would need to possess the same qualities and therefore, contain at least one or more D-amino acids. Such proteins may cause unfolded protein response resulting in severe local and systemic inflammation.
  • Covid-19 pandemic like no other case demonstrates the need for a strategy capable to address not only matters of life and death of a specific virus but also all types of degenerative pathologies plus aging related issues. In fact, charts of incidents of degenerative diseases/death rate of Covid-19 versus age speaks for themselves. The best solution is in shifting human body back in time, to the state characteristic for 20 - 25 years old person. [0079] The ideal material for prevention and treatment of Covid-19 must combine several features and be able to:
  • an energy level is called degenerate if it corresponds to two or more different states of a quantum system.
  • Amino acid with opposite chirality present in the one and the same protein is a good analog of degenerate state for biomolecule.
  • the problem is that a mixture of L and D-amino acids cannot form helices at all. Presence of even one D-amino acid in the protein will always lead to distortion of the helices.
  • DNA-like structures are made of plastic or CeCh particles formed in the field produced by two interconnected generators. One for plasma production and another for the modulation of electric field.
  • solenoidal/helical structures indicates that not electric but electromagnetic fields in competition of modes regime are involved in this process. It makes sense to consider the role of the competition of modes produced by electron subsystem and nucleus of atoms in the formation of chemical bonds and helical structures of proteins and DNA.
  • Wrong conformation of protein may be accommodated by the formation of one or more D-amino acids.
  • Both distortion of helixes and mirror-image amino acids may be isotope-induced in result of the substitution of lightest isotopes by heavy ones of the same chemical element.
  • Isotope-induced changes in the symmetry of biomolecules can be caused not only by such basic elements as hydrogen, carbon, oxygen, and nitrogen but also by essential chemical elements. • Isotope-induced chirality and its amplification in asymmetric autocatalysis could go in both directions. It means that reverse isotope selective autocatalytic reactions may lead to the isotope separation in live cells.
  • isotope separation effect could be the most critical feature which defines the fate of live cells and makes all the difference between normal and pathology affected cells and tissues, young and senescent cells, and at the end - between life and death.
  • Isotope composition of biomolecules should be a decisive factor for stability /homeostasis in both healthy/young organism and efficient pathogens (whether it is bacteria or virus).
  • the sources of our energy and construction material of human body are not inhibitors and activators, antibodies, and CAR-T cells but degenerate chemical elements which are in fact a mixture of various stable isotopes.
  • isotope ratios for all chemical elements are practically one and the same and not only on our planet but in all corners of the Universe. Deviations from natural abundance in the same chemical element exist but on the level of parts per million only. Inorganic materials, on the other hand, are quite different from biomolecules. They do not have a hierarchical structure with helical/sol enoidal component on the top level. Their crystalline structure can be well described based on Coulombic interaction so that there is no reason to expect any significant effects related to nucleus composition including isotope induced changes of symmetry.
  • isotopes are separated, and light ones are used in the production of hormones, which are very important polypeptides and proteins in the body, then, the byproduct of such production process - heavy isotopes - should be accumulated nearby production sites and attract loose single cancer cells and other pathogens being their feeding ground. It plays well with the role of comorbidities in Covid-19 infection and death rate also.
  • the “isotope ratios” can be changed of essential chemical elements in favor of atoms that have an equal number of protons and neutrons or minimum excess of neutrons over protons.
  • the ideal therapeutic composition should include a mixture of the lightest isotopes of essential chemical elements in the amounts proportional to the correspondent daily consumption dose. This approach should be sufficient to correct the structure of the metalloproteins but not of all proteins. To make sure that all proteins are produced without mistakes all stages of their synthesis and assembly must be addressed; these are transcription, translation, and posttranslational modification.
  • Ribosomes synthesize peptides from amino acids according to the instruction from messenger RNAs and are one of the most important molecular machines in live cells. The quality of ribosomes defines the quality of proteins.
  • a ribosome is composed of a large subunit and a small subunit, together consisting of three to four ribosomal RNAs (rRNAs) and dozens of ribosomal proteins (r-proteins).
  • rRNAs ribosomal RNAs
  • r-proteins ribosomal proteins
  • Common features in ribosomal proteins are zinc finger motifs, which have been associated with the proteins of both subunits of the ribosomes. Ribosomal proteins play a major role as RNA-binding proteins. Success of the translation process hinges on proper binding of zinc finger proteins and therefore, on their conformation. The average lifetime of ribosomes is 4-6 minutes. They are rapidly produced in autocatalytic reactions. Autocatalytic reactions may amplify the yield of proteins with the wrong conformation induced by isotope substitution of heavy isotopes. The probability of these events is quite low for non- metalloproteins, as their atoms light isotopes ratio is close to 100%
  • Zinc is recognized as one of the most essential chemical elements in the human body. Numerous scientific articles have documented the effect of excess or lack of zinc on human health. The influence of zinc is mentioned in relation to at least 60 diseases. However, the most important issue is which precise zinc of the five stable isotopes is not addressed in scientific literature. It is this issue that is fundamental to the proper operation of the ribosome and therefore, for synthesis of all proteins with the correct conformation.
  • the isotope ratio of light isotope Zn-64 significantly exceeds natural abundance. Conversely, a much higher concentration of heavy zinc isotopes is observed in the cells of pathology affected tissues. A short-term or long-term increase in the concentration of light zinc isotopes in the cytoplasm of cells will ensure their access to the ribosomes. This will lead to a sharp increase in the proportion of proteins with the correct conformation produced by ribosomes. The goal is to replace all damaged/old biomolecules, including all receptors and signaling molecules with new/young ones made of predominantly light isotopes.
  • compositions that increase the isotope ratio of Zn-64 in the cytoplasm of living cells is a completely new family of drugs with general effect. Such drugs create conditions incompatible with life of cells affected by the most serious pathologies, such as cancer, for example.
  • 64 Zn the lightest epitope of Zinc
  • 64 Zn e the lightest epitope of Zinc
  • the studies summarized in this section use 64 Zn or 64 Zn e -based compositions administered to an animal subject by, for example, injection, but not as food to an animal subj ect.
  • Reduced cytoplasmic Slug expression in A-549 cells may indicate inhibition of their malignancy. It is known that Slug (a zinc finger protein) is a direct E-cadherin repressor and an increase in the expression of this transcription factor causes a decrease in the E-cadherin expression. However, COLO 205 cells exposed to 64 Zn showed an increase in the Slug expression level against the background of increased E-cadherin expression. In addition, it is known that stable overexpression of Slug is accompanied by an increase in the sensitivity of cancer cells to anticancer drugs that target microtubules of the cell cytoskeleton and tubulin. Thus, it can be assumed that an increase in the Slug expression in COLO 205 cells with a mesenchymal phenotype does not lead to an increase in their malignancy but increases their sensitivity to the action of cytostatic agents.
  • a significant increase in the expression of pro- apoptotic proteins Bax and p53 may indicate the activation of apoptosis in MM-4 mouse melanoma cells as a result of their treatment with Zn64 Aspartate at a concentration that should not lower than IC50.
  • MMPs metalloproteinases 2 and 9
  • MMP-9 and MMP-2 are particularly important elements of the tumor microenvironment since they take an active part in the regulation of metabolism and cell cycle in tumor cells. It is also known that a decrease in the activities of MMP-9 and MMP-2 in tumor tissue is accompanied by suppression of tumorigenicity and tumor invasiveness. Analysis of the activities of latent (pro-MMP-2 and pro- MMP-9) and active forms (MMP-2 and MMP-9) of metalloproteinases in MM-4 cells after their treatment with Zn64 Aspartate showed a significant and dose-dependent suppression of the activities of these gelatinases.
  • test substance Zn64 Aspartate
  • the concentration of 16.69 pg/ml caused a statistically significant decrease in the activities of latent pro-MMP-2 and pro-MMP-9 forms (by 76.5% and 61.2%, respectively, compared with the control), as well as of active MMP-2 and MMP-9 forms of metalloproteinases (by 66.8% and 23.8%, respectively, compared with the control).
  • Culture of melanoma cells at the presence of Zn64 Aspartate at the concentration of 25.03 pg/ml was accompanied by statistically significant suppression of the activities of MMP-2 and MMP-9 by 76% and 18.8%, respectively, compared with the control.
  • the findings suggest that the test substance not only suppresses proliferation of MM-4 cells, but it may also reduce their malignancy.
  • Modem methods of medicine are aimed at inhibiting certain receptors and signaling pathways in diseased cells. This inevitably leads to the activation of a destructive positive feedback loop in both healthy and pathology-affected cells, with all the ensuing consequences.
  • the disclosed technology aims to restore healthy and youthful homeostasis in adult and old organisms with no effect on the young ones unless correction is required. This target is achieved by rejuvenation of immune and endocrine systems and adding Geno-protective ability to live cells.
  • Zn-64 Asp can be used as monotherapy or in combination with other drugs for the improvement of overall metabolic status under the development of obesity and prevention of the obesity-related disorders
  • Zn-64 Asp normalizes cytokine profile of the serum and adipose tissue in animals on a high-fat diet:
  • Zn-64 Asp causes either an increase in the activity of insulin relative to its receptor in tissues or an increase in the amount of this hormone in the bloodstream
  • Zinc-64 either has a more prolonged effect on insulin levels in blood serum or is more slowly released from the sites of deposition compared to Zn-natural
  • a decreased number of hippocampal dopaminergic neurons and decreased expression of tyrosine hydroxylase in hippocampal dopaminergic neurons were recorded in rat models of AbI-40-induced AD.
  • Administration of 64 Zn-asp to Ab ⁇ - 40 AD rats increased the staining intensity of TH-immuno-positive cells rather than their number.
  • KLS-1 64 Zn e aspartate
  • the mechanism of KLS-1 ( 64 Zn e aspartate) action is based on the prevention of virus penetration through the receptor - zinc metalloenzyme ACE 2 to a new cells and inhibition of coronavirus reproduction in already affected cells.
  • Homeostasis restoration effect is achieved by the correction of cells proteins production in ribosomes.
  • KLS-1 represents a new platform critical for defeating not only Covid-19 coronavirus but also its possible any future mutant derivatives.
  • Zinc glutamate and zinc-64 light isotope glutamate composites in deuterium- depleted water effectively inhibited the reproduction of influenza, herpes and surrogate hepatitis C viruses, but the efficacy index of light isotope in all viral reproductive systems was several times lower than that of natural zinc since the CC50 of light isotopes of Zn in deuterium-depleted water is much higher.
  • MBC minimum bactericidal concentration
  • the MBC of the test samples was determined as the lowest concentration at which there was no growth on Mueller-Hinton agar medium. The established MBC values are given in Table 4. [00149] Table 4. The MBC for all samples of the antibacterial composition based on light isotope 64 Zn e for test cultures
  • the antibacterial composition had a pronounced bacteriostatic and bactericidal activity. All samples of the composition had good indicators of bacteriostatic activity against S. aureus and E. coli. As fori 5 , aeruginosa, the best results were recorded for the antibacterial composition which included 64 Zn e in the form of salt with EDDA, aspartic acid, and glutamic acid. Bactericidal activity of the antibacterial composition against S. aureus and E. coli was sufficiently high in all the samples.
  • the antibacterial composition containing 64 Zn-enriched zinc demonstrated a bacteriostatic activity which is significantly higher than that of the natural zinc-based preparations with the natural isotope distribution (by a factor of about 15 to about 2000 maximum).
  • the bactericidal activity of the composition in all cases was significantly higher than that of the preparation containing natural zinc in the form of similar salt.
  • the bacteriostatic and bactericidal activities of the antibacterial composition is directly attributable to the presence of light isotope 64 Zn-enriched zinc in the form of a salt of an organic or inorganic acid.
  • MBC established for the antibacterial agents are shown in Tables 7 and 8, respectively.
  • the MIC and MBC of the commercial antibacterial agents are much inferior to those of the Zn-64 antibacterial composition, which confirms its efficiency and expediency of application for the control of pathogenic microorganisms. Therefore, the use of KLS-1 in both prevention and therapeutic modes can be decisive factor in winning against Covid-19 as the most dangerous phase of this disease is characterized as viral- bacterial pneumonia with respiratory anatomical space colonized by various bacteria.
  • adipose tissue is not only an energy depot of the body, but also an organ that is actively involved in the regulation of metabolism through a complex of endocrine, paracrine and autocrine signals modulating responses of many tissues and organs, including the hypothalamus, hypophysis, pancreas, liver, skeletal muscles, kidneys, endothelium, the immune system, etc.
  • adipose tissue secretes more than 50 protein factors, hormones, and growth factors, including cytokines.
  • pro-inflammatory cytokines such as IL-1, IL- 6, IL-8, IL-12, TNF-a, IFN-g and anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, TGF.
  • pro-inflammatory cytokines such as IL-1, IL- 6, IL-8, IL-12, TNF-a, IFN-g
  • anti-inflammatory cytokines such as IL-4, IL-10, IL-13, TGF.
  • Chronic inflammation in adipose tissue is characterized by cellular infiltration, fibrosis, microcirculation changes, impaired adipokine secretion and adipose tissue metabolism disorders, as well as increased blood levels of such nonspecific inflammatory markers as C-reactive protein, fibrinogen, and leukocytes.
  • Cytokines as endogenous biologically active mediators that regulate intercellular and intersystem interactions, influence the survival of cells by regulating their growth, differentiation, functional activity, and apoptosis. They ensure coordination of actions of the immune, endocrine and nervous systems under physiological conditions and in response to pathological effects. It was previously believed that cytokines were produced by lymphocytes, monocytes and tissue macrophages. However, the results from recent research show that, in obesity, as in any inflammatory process, infiltration of neutrophils, T-lymphocytes, and then resident macrophages into adipose tissue occurs at an early stage, which determines the initial mechanisms of inflammation.
  • adipocytes contribute to hypertrophy of adipocytes, which is accompanied by an increase in their functional activity and increased synthesis of cytokines and leads to further intensification of the inflammatory response.
  • Hypertrophied adipocytes intensely secrete chemokines and their receptors, which stimulate the influx of new neutrophils, macrophages and lymphocytes, thus contributing to a further increase in adipocyte hypertrophy, preservation and intensification of the inflammatory response.
  • Adipocytes increase the secretion of cytokines by macrophages, which in turn act on adipocytes, causing hypertrophy and activation of adipose tissue cells.
  • lipid peroxidation products such as trans-4-oxy-2-nonenal and malonic dialdehyde, are chemo-attractants for monocytes and macrophages. Strengthening of the processes of lipid peroxidation in accumulated adipose tissue contributes to the attraction and infiltration of macrophages into adipose tissue in obesity, thus actively contributing to the launch of inflammation reactions.
  • an increasing adipose tissue mass is a constant source of pro- inflammatory cytokines synthesized both by adipocytes and macrophages incorporated into adipose tissue, which leads to the formation of a chronic inflammatory process and maintenance of inflammation in the body. Its low intensity does not give direct clinical symptoms, but at the same time, this process is systemic in nature, which means that it affects a wide range of organs and tissues causing changes in their metabolism and impairing their function and immune system reactions.
  • the next phase was to find out whether the administration of Zn- 64 stable isotope in aspartate form influences the cytokine profile in obese animals.
  • concentrations of the main pro-inflammatory (IL-1, IL-6, IL-12, IFN-g) and antiinflammatory (IL-4, IL-10, TGF) cytokines in adipose tissue and serum of experimental animals were determined, which allowed us to make a conclusion about the intensity of the inflammatory process in adipose tissue and assess whether such inflammatory process is systemic.
  • IL-12 the expression of which is activated by IFN-g, lead to infiltration of CD8 + lymphocytes in the pancreas and the development of acute pancreatitis.
  • IL-Ib via binding to specific receptors on the surface of these cells, causes activation of NF-icB-mediated apoptosis, which leads to DNA fragmentation and loss of functional activity of cells.
  • IL-Ib may also be regarded as one of the factors contributing to the development of resistance of peripheral tissues to insulin.
  • IL-Ib has been shown to activate IKB kinase-b which influences insulin signaling by phosphorylating a serine residue in the insulin receptor substrate (IRS)-l.
  • IKB kinase-b which influences insulin signaling by phosphorylating a serine residue in the insulin receptor substrate (IRS)-l.
  • IL-Ib can increase resistance to the action of insulin indirectly, by activating lipogenesis in the liver and contributing to an increase in the levels of triglycerides and free fatty acids in adipocytes.
  • IL-6 is accumulated in direct proportion to an increase in the adipose tissue mass in peripheral blood.
  • Adipocytes are the second largest source of IL-6 after the immune system: 35% of circulating IL-6 is synthesized by adipose cells. Its concentration in the blood is directly proportional to the body mass index and is increased in obesity. At the same time, a decrease in body weight is accompanied by a decrease in the blood levels of IL-6. When in excess, IL-6 exacerbates insulin resistance by suppressing synthesis of one of the insulin receptor subunits.
  • IL-6 By activating lipolysis in visceral adipose tissue, IL-6 contributes to the progressive development of fatty hepatosis and systemic atherosclerosis. In addition, IL-6 induces increased production of C-reactive protein (CRP), another factor associated with obesity.
  • CRP C-reactive protein
  • pro-inflammatory cytokines One of the controlling mechanisms for the levels and, accordingly, the biological effects of pro-inflammatory cytokines is implemented by a group of anti-inflammatory cytokines. These cytokines can inhibit the synthesis of pro-inflammatory cytokines by affecting transcription of specific genes, induce the synthesis of receptor antagonists of interleukins RAIL, enhance the production of soluble receptors and reduce the density of pro-inflammatory receptors on cells. Therefore, to clarify possible mechanisms of the effects of Zn-64 stable isotope in aspartate form on the profile of pro-inflammatory cytokines, the levels of IL-4, IL-10, and TGF were determined.
  • the pathogenesis of obesity is accompanied by a systemic chronic inflammatory process, the intensity of which can be assessed by the serum levels of pro- and anti-inflammatory cytokines.
  • Zinc-64 may also partially block genes encoding pro-inflammatory cytokines, such as IL-6 and IL-8.
  • KLS-1 Zn-64 aspartate
  • KLS-1 accompanied by a positive therapeutic effect, was associated with an increase in the metabolic activity of microglia with a significant activation of their phagocytic function involved in reparative processes, which is indicative of the restorative homeostatic effect of the KLS-1.
  • Progression of LPS-induced parkinsonism is accompanied by pronounced peripheral inflammation, as evidenced by mono-cytosis in combination with an increase in the neutrophil-lymphocyte ratio.
  • Therapeutic administration of the KLS-1 reduces systemic inflammatory responses. . Phenotypic and metabolic characteristics of circulating phagocytes indicate their functional depletion caused by prolonged systemic inflammatory process, simultaneously with a proinflammatory shift in their functional activity.
  • Administration of the KLS-1 is accompanied by a functional restoration of circulating phagocytes with an anti-inflammatory shift in their metabolism.
  • Progression of LPS-induced parkinsonism is accompanied by involvement of MALT immunocytes in the generalized inflammatory process with their proinflammatory activation.
  • Administration of the KLS-1 induces homeostatic changes in metabolism in these cells with their proinflammatory metabolic shift.
  • AD induced by Ab 1-40 infusion was characterized by a prolonged acute local (in microglia) inflammatory process and a moderately expressed systemic manifestation of inflammation with signs of its spontaneous resolution.
  • a slight manifestation of systemic inflammation in this model is its weak point since clinical manifestation of AD is characterized by a pronounced systemic inflammation.
  • AD induction was also accompanied by expressive neutrophilia with a significant (more than 4-fold) increase in the neutrophilic lymphocytic coefficient (the ratio of the absolute number of neutrophils to the absolute number of peripheral blood lymphocytes, NLC).
  • NLC is one of the early markers of AD development and an important prognostic criterion for cognitive impairment.
  • the therapeutic administration of the zinc preparation was associated with the complete normalization of NLC, both due to an increase in the number of lymphocytes (which is a criterion for the resolution of inflammation involving regulatory cells), and due to a significant decrease in the number of segmented neutrophils.
  • isotope selective therapy is because this therapy unlike existing treatments acts on the root cause of pathology: isotope substitution induced distortion of helices in proteins structure, the emergence of D-amino acids in proteins, changes in their conformation, unfolding and aggregation.
  • Zinc fingers in ribosomes play critical role in the onset of pathogenesis. Ribosomes produce all proteins. The essence of this technology is to change isotope ratios of zinc in these biomolecules creating necessary conditions for the wild type proteins production. All proteins. How can one tell if it works? After all, it is quite difficult to test conformation of 20,000 proteins in humans.
  • pathology affected live cells are enriched in heavy isotopes and healthy cells with normal proteins must be enriched in light isotopes.
  • the replacement of heavy zinc isotopes in ribosomes by Zn-64 should guarantee the synthesis of wild type proteins enriched with light isotopes.
  • This also applies to metalloproteins. Therefore, the easiest way to check the fundamentals of this technology - by the verification of the isotope ratios of essential chemical elements in any organ of animal after Zn- 64 infusion. Once again, even though it is intended to increase concentration of Zn-64 in the blood stream, the isotope ratios shift should be detected in favor of lightest ones not only in zinc but in other metals as well.
  • proteins in the healthy living cell should contain only the lightest isotopes of hydrogen, oxygen, nitrogen, carbon essential chemical elements. Potassium and rubidium, whether they bind to proteins or are playing other roles in cell’s life, are required to be in the form K-39 and Rb-85 isotopes. Ail chemical elements coming into the body with food have isotope ratios in accordance with their well-known natural abundance. Exactly this ratio should be expected to be in the cell’s cytoplasm. Protein accounts for approximately 20 percent of a cell’s total weight. Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition.
  • the best solution of this problem is to consume isotope selective foods/agricultural products grown in soil fertilized with light isotopes of essential chemical elements.
  • the lightest stable isotopes of essential chemical elements in therapeutic and preventive compounds with various salts and amino acids or biomolecules as vehicles should be used.
  • the best vehicles are chemical compounds in plant foods.
  • salts and amino acids based therapeutic compounds enriched with lightest isotopes of essential chemical elements can be used as a new type of nutrients or “fertilizers” in the process of agricultural production of various crops, fruits, and vegetables.
  • Daily consumption of isotope-selective food is the best way for continuous maintenance of youthful homeostasis i.e. stability of human organism with simultaneous prevention from degenerative and infectious diseases.
  • Daily consumption doses for essential chemical elements taken with foods are equal to the therapeutic doses determined during phase 1-2 clinical study in patients with metastatic solid tumors, autoimmune diseases, diabetes 1&2, obesity, aphasia, and Parkinson’s disease.
  • Plants producing plant products are grown in hydroponics with a solution comprising lightest isotopes of essential chemical elements in specified concentrations, as shown in Table 12.
  • the solution is changed either on a schedule, such as once per week, or when the concentration of one or more nutrients drops below a certain level as determined with an electrical conductivity meter. Whenever the solution is depleted below a certain level, either water or fresh solution is added, with the solution comprising light isotopes of essential chemical elements as shown in Table 12.
  • the plant products crops
  • Food is prepared for human consumption from the products of these plants.
  • the plants, the plant products, and the food made from these plants/plant products can be verified to comprise enriched light isotopes of K-39, Ca-40, Mg-24, Zn-64, and Fe-54 by methods conventional in the art, such as by mass spectrometry.
  • EXAMPLE 2 PLANTS GROWN IN SOIL WITH ENRICHED ZN-64 AS FERTILIZER
  • Fertilizer comprising Zn-64 sulfate is added to soil before planting plants in the soil or while the plants have not fully grown. Other dry fertilizer materials may also be added to the soil Any salts or chelates of Zn-64 can be used as fertilizer. Zn-64 sulfate is used in this example. One pound of Zinc-64 per acre is added. Plants are then planted in this soil. The fertilizer comprising Zn-64 sulfate may be added to the soil over time, either when the level of Zn-64 sulfate in the soil is low or on a schedule. The plants or plant products are harvested when ready. Food may be prepared from the plants or plant products for human consumption.
  • the plants, the plant products, and the food made from these plants/plant products can be verified to comprise enriched Zn-64 and may comprise enriched light isotopes of other essential chemical elements by methods conventional in the art, such as by mass spectrometry.
  • Zn-64 is supplied to the plant crops through foliar feeding.
  • powdered Zinc-64 sulfate is dissolved in an aqueous solution and sprayed on the leaves of the plants as they grow.
  • 25 gallons of solution per acre should contain from 1 5 to 3 pounds of Zn-64 sulfate to deliver from 0.5 to 1 pound of Zn-64 per acre.
  • the plants or plant products are harvested when ready. Food may be prepared from the plants or plant products for human consumption.
  • the plants, the plant products, and the food made from these plants/plant products can be verified to comprise enriched Zn-64 and may comprise enriched light isotopes of other essential chemical elements by methods conventional in the art, such as by mass spectrometry.
  • Pigs and chickens are fed a diet with food comprising Zn-64 as they grow. Any salts or chelates of Zn-64 can be used, such as Zinc64 Aspartate. Eggs from the chickens are collected and may be consumed. The pigs, the chickens, the eggs from the chickens, and food made from the pigs and chickens can be verified to comprise enriched Zn-64 and may comprise enriched light isotopes of other essential chemical elements by methods conventional in the art, such as by mass spectrometry.
  • Salt water fish such as sea bass, grown in aquaculture are fed a solution comprising Zn-64 as they grow.
  • Any salts or chelates of Zn-64 can be used, such as Zinc64 Aspartate.
  • the sea bass can be verified to comprise enriched Zn-64 and may comprise enriched light isotopes of other essential chemical elements by methods conventional in the art, such as by mass spectrometry.

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Abstract

L'invention concerne des aliments modifiés pour favoriser la santé et maintenir l'homéostasie chez un sujet ainsi que des procédés de production de ces aliments.
PCT/US2021/024433 2021-03-26 2021-03-26 Aliments pour favoriser une meilleure santé et/ou pour maintenir l'homéostasie et leur procédé de production WO2022203684A1 (fr)

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PCT/US2021/024433 WO2022203684A1 (fr) 2021-03-26 2021-03-26 Aliments pour favoriser une meilleure santé et/ou pour maintenir l'homéostasie et leur procédé de production
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