WO2022173238A3 - 생적합성 양자점-폴리머 복합체 및 이를 이용한 진단 키트 - Google Patents

생적합성 양자점-폴리머 복합체 및 이를 이용한 진단 키트 Download PDF

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Publication number
WO2022173238A3
WO2022173238A3 PCT/KR2022/002028 KR2022002028W WO2022173238A3 WO 2022173238 A3 WO2022173238 A3 WO 2022173238A3 KR 2022002028 W KR2022002028 W KR 2022002028W WO 2022173238 A3 WO2022173238 A3 WO 2022173238A3
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Prior art keywords
polymer composite
quantum dot
same
diagnostic kit
quantum
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PCT/KR2022/002028
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English (en)
French (fr)
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WO2022173238A2 (ko
Inventor
박종남
김성환
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울산과학기술원
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Priority claimed from KR1020220016432A external-priority patent/KR20220115526A/ko
Application filed by 울산과학기술원 filed Critical 울산과학기술원
Priority to US18/276,829 priority Critical patent/US20240118275A1/en
Priority to EP22752998.9A priority patent/EP4293355A2/en
Priority to CN202280027744.5A priority patent/CN117120844A/zh
Publication of WO2022173238A2 publication Critical patent/WO2022173238A2/ko
Publication of WO2022173238A3 publication Critical patent/WO2022173238A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K9/00—Use of pretreated ingredients
    • C08K9/02—Ingredients treated with inorganic substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/0883—Arsenides; Nitrides; Phosphides
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/70—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing phosphorus
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/88—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
    • C09K11/881—Chalcogenides
    • C09K11/883—Chalcogenides with zinc or cadmium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/002—Physical properties
    • C08K2201/005—Additives being defined by their particle size in general
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/011—Nanostructured additives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

본 발명은 코어-쉘 구조를 갖는 하나 이상의 양자점(quantum dot), 상기 양자점 표면에 배치된 표면 개질 리간드 및 하나 이상의 폴리머 리간드로 이루어진 3차원 자기 조립 구조(3D selfassembly structure)의 양자 비드(quantum bead)를 포함하고, 상기 하나 이상의 양자점이 상기 양자 비드 내에 분산되고, 상기 코어는 인듐 인화물(InP)을 포함하고, 상기 쉘의 두께는 3 nm 내지 9nm인, 양자점-폴리머 복합체, 상기 양자점-폴리머 복합체를 포함하는 면역 검출용 접합체 및 이를 이용한 진단용 키트에 관한 것이다.
PCT/KR2022/002028 2021-02-10 2022-02-10 생적합성 양자점-폴리머 복합체 및 이를 이용한 진단 키트 WO2022173238A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US18/276,829 US20240118275A1 (en) 2021-02-10 2022-02-10 Biocompatible quantum dot-polymer composite and diagnostic kit using same
EP22752998.9A EP4293355A2 (en) 2021-02-10 2022-02-10 Biocompatible quantum dot-polymer composite and diagnostic kit using same
CN202280027744.5A CN117120844A (zh) 2021-02-10 2022-02-10 生物相容性量子点-聚合物复合物及使用其的诊断试剂盒

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2021-0019364 2021-02-10
KR20210019364 2021-02-10
KR10-2022-0016432 2022-02-08
KR1020220016432A KR20220115526A (ko) 2021-02-10 2022-02-08 생적합성 양자점-폴리머 복합체 및 이를 이용한 진단 키트
KR1020220016671A KR20220115530A (ko) 2021-02-10 2022-02-09 생적합성 양자점-폴리머 복합체 및 이를 이용한 진단 키트
KR10-2022-0016671 2022-02-09

Publications (2)

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WO2022173238A2 WO2022173238A2 (ko) 2022-08-18
WO2022173238A3 true WO2022173238A3 (ko) 2022-10-06

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US (1) US20240118275A1 (ko)
EP (1) EP4293355A2 (ko)
WO (1) WO2022173238A2 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120205598A1 (en) * 2011-02-16 2012-08-16 Shenzhen Thales Science & Technology Co., LTD. "Green" synthesis of colloidal nanocrystals and their water-soluble preparation
KR20150093544A (ko) * 2014-02-07 2015-08-18 한국과학기술연구원 양자점 층을 포함한 비드 입자를 포함하는 복합체 및 이를 이용한 심근경색 관련 질환의 진단 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210019364A (ko) 2019-08-12 2021-02-22 주식회사 신단수디자인 산업폐기섬유를 재활용한 방음 벽지의 제조방법
KR20220016432A (ko) 2020-07-31 2022-02-09 현대중공업 주식회사 액화가스 저장탱크 및 이를 포함하는 선박
KR20220016671A (ko) 2020-08-03 2022-02-10 세메스 주식회사 약액 토출 장치 및 약액 토출 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120205598A1 (en) * 2011-02-16 2012-08-16 Shenzhen Thales Science & Technology Co., LTD. "Green" synthesis of colloidal nanocrystals and their water-soluble preparation
KR20150093544A (ko) * 2014-02-07 2015-08-18 한국과학기술연구원 양자점 층을 포함한 비드 입자를 포함하는 복합체 및 이를 이용한 심근경색 관련 질환의 진단 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOMINIK JAŃCZEWSKI, TOMCZAK NIKODEM, HAN MING-YONG, VANCSO G JULIUS: "Synthesis of functionalized amphiphilic polymers for coating quantum dots", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 6, no. 10, GB , pages 1546 - 1553, XP055335362, ISSN: 1754-2189, DOI: 10.1038/nprot.2011.381 *
KE XIANLIANG, ZHANG YUAN, ZHENG FANGLIANG, LIU YAN, ZHENG ZHENHUA, XU YI, WANG HANZHONG: "SpyCatcher–SpyTag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 54, no. 10, 1 January 2018 (2018-01-01), UK , pages 1189 - 1192, XP055973150, ISSN: 1359-7345, DOI: 10.1039/C7CC08880A *
XU YANXIA, YANBING LV,RUILI WU,HUAIBIN SHEN,HUAWEI YANG,HAN ZHANG,JINJIE LI,LIN SONG LI: "Preparation of highly stable and photoluminescent cadmium‐Free InP/GaP/ZnS core/shell quantum dots and application to quantitative immunoassay", PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, vol. 37, no. 3, 31 January 2020 (2020-01-31), pages e1900441, XP055973152, DOI: 10.1002/ppsc.201900441 *

Also Published As

Publication number Publication date
US20240118275A1 (en) 2024-04-11
EP4293355A2 (en) 2023-12-20
WO2022173238A2 (ko) 2022-08-18

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